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18 results on '"Jorde, Anne"'

8. Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk

Author

Bach, Patrick, primary, Zois, Evangelos, additional, Vollstädt-Klein, Sabine, additional, Kirsch, Martina, additional, Hoffmann, Sabine, additional, Jorde, Anne, additional, Frank, Josef, additional, Charlet, Katrin, additional, Treutlein, Jens, additional, Beck, Anne, additional, Heinz, Andreas, additional, Walter, Henrik, additional, Rietschel, Marcella, additional, and Kiefer, Falk, additional

Published
2017
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9. 313. Cortical Surface Based Threshold Free Cluster Enhancement and Cortex-Wise Mediation

Author

Lett, Tristram, primary, Waller, Lea, additional, Tost, Heike, additional, Veer, Ilya, additional, Nazeri, Arash, additional, Erk, Susanne, additional, Brandl, Eva, additional, Charlet, Katrin, additional, Beck, Anne, additional, Vollstädt-Klein, Sabine, additional, Jorde, Anne, additional, Kiefer, Falk, additional, Heinz, Andreas, additional, Meyer-Lindenberg, Andreas, additional, Chakravarty, Mallar, additional, and Walter, Henrik, additional

Published
2017
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11. Cortical surface‐based threshold‐free cluster enhancement and cortexwise mediation

Author

Lett, Tristram A., primary, Waller, Lea, additional, Tost, Heike, additional, Veer, Ilya M., additional, Nazeri, Arash, additional, Erk, Susanne, additional, Brandl, Eva J., additional, Charlet, Katrin, additional, Beck, Anne, additional, Vollstädt‐Klein, Sabine, additional, Jorde, Anne, additional, Kiefer, Falk, additional, Heinz, Andreas, additional, Meyer‐Lindenberg, Andreas, additional, Chakravarty, M. Mallar, additional, and Walter, Henrik, additional

Published
2017
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12. Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk.

Author

Bach, Patrick, Zois, Evangelos, Vollstädt‐Klein, Sabine, Kirsch, Martina, Hoffmann, Sabine, Jorde, Anne, Frank, Josef, Charlet, Katrin, Treutlein, Jens, Beck, Anne, Heinz, Andreas, Walter, Henrik, Rietschel, Marcella, Kiefer, Falk, and Vollstädt-Klein, Sabine

Subjects
GRAY matter (Nerve tissue), BRAIN, RESEARCH, ALCOHOLISM, TEMPORAL lobe, ALCOHOL dehydrogenase, ANTHROPOMETRY, RESEARCH methodology, DESIRE, GENETIC polymorphisms, EVALUATION research, MEDICAL cooperation, DISEASE relapse, COMPARATIVE studies, ALCOHOL drinking, RESEARCH funding, PROPORTIONAL hazards models
Abstract

Alcohol metabolizing enzymes, such as the alcohol dehydrogenases and the aldehyde dehydrogenases, regulate the levels of acetaldehyde in the blood and play an important role in the development and maintenance of alcohol addiction. Recent genome-wide systematic searches found associations between a single nucleotide polymorphism (rs1789891, risk allele: A, protective allele: C) in the alcohol dehydrogenase gene cluster and the risk of alcohol dependence. The current study investigated the effect of this single nucleotide polymorphism on alcohol consumption, craving for alcohol, relapse risk and brain gray matter volume. Alcohol-dependent patients (n = 74) and controls (n = 43) were screened, genotyped and underwent magnetic resonance imaging scanning, and relapse data were collected during 3 months following the experiment. Alcohol-dependent A allele carriers reported increased alcohol craving and higher alcohol consumption compared with the group of alcohol-dependent individuals homozygous for the C allele, which displayed craving values similar to the control group. Further, follow-up data indicated that A allele carriers relapsed earlier to heavy drinking compared with individuals with two C alleles. Analyses of gray matter volume indicated a significant genotype difference in the patient group: individuals with two C alleles had reduced gray matter volume in the left and right superior, middle and inferior temporal gyri. Findings of the current study further support the relevance of genetic variants in alcohol metabolizing enzymes to addictive behavior, brain tissue volume and relapse risk. Genotype-dependent differences in acetaldehyde formation, implicated by earlier studies, might be the biological substrate of the genotype differences. [ABSTRACT FROM AUTHOR]

Published
2019
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13. Genetic Variation in the Atrial Natriuretic Peptide Transcription Factor GATA4 Modulates Amygdala Responsiveness in Alcohol Dependence

Author

Jorde, Anne, primary, Bach, Patrick, additional, Witt, Stephanie H., additional, Becker, Kathleen, additional, Reinhard, Iris, additional, Vollstädt-Klein, Sabine, additional, Kirsch, Martina, additional, Hermann, Derik, additional, Charlet, Katrin, additional, Beck, Anne, additional, Wimmer, Lioba, additional, Frank, Josef, additional, Treutlein, Jens, additional, Spanagel, Rainer, additional, Mann, Karl, additional, Walter, Henrik, additional, Heinz, Andreas, additional, Rietschel, Marcella, additional, and Kiefer, Falk, additional

Published
2014
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15. Molecular Detection and Identification of Zygomycetes Species from Paraffin-Embedded Tissues in a Murine Model of Disseminated Zygomycosis: a Collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) Evaluation

Author

Dannaoui, Eric, primary, Schwarz, Patrick, additional, Slany, Michal, additional, Loeffler, Juergen, additional, Jorde, Anne Tomine, additional, Cuenca-Estrella, Manuel, additional, Hauser, Philippe M., additional, Shrief, Raghdaa, additional, Huerre, Michel, additional, Freiberger, Tomas, additional, Gaustad, Peter, additional, Rodriguez-Tudela, Juan-Luis, additional, Bille, Jacques, additional, Denning, David W., additional, Bretagne, Stéphane, additional, and Lortholary, Olivier, additional

Published
2010
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17. 18S rDNA Polymerase Chain Reaction and Sequencing in Onychomycosis Diagnostics.

Author

Walberg, Mette, Mørk, Cato, Sandven, Per, Jorde, Anne Tomine, Bjørås, Magnar, and Gaustad, Peter

Subjects
DNA polymerases, POLYMERASE chain reaction, NUCLEOTIDE sequence, ONYCHOMYCOSIS, DERMATOPHYTES, SKIN disease diagnosis, SKIN disease treatment
Abstract

Diagnostic approaches to onychomycosis have traditionally been based on a combination of culture and microscopy. In the present study clinical specimens from 346 patients with suspected onychomycosis were analysed by 18S polymerase chain reaction (detection) followed by sequencing and subsequent database search (identification) in parallel with routine culture on agar (detection and identification). In 49 samples Trichophyton rubrum was identified by culture and sequencing. In 67 additional culture negative samples, a positive dermatophyte sequence was obtained (T. rubrum in 54, T. mentagrophytes in 5, and T. species in 8 samples). Fifteen samples cultured positive while no sequence was obtained. Two hundred and seven samples were negative by culture as well as by sequencing. Nails from 10 healthy controls were negative by culture and sequencing. In conclusion, the number of specimens that were positive by polymerase chain reaction was more than double the number that were positive by culture alone. [ABSTRACT FROM AUTHOR]

Published
2006
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18. Molecular Detection and Identification of ZygomycetesSpecies from Paraffin-Embedded Tissues in a Murine Model of Disseminated Zygomycosis: a Collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) Evaluation

Author

Dannaoui, Eric, Schwarz, Patrick, Slany, Michal, Loeffler, Juergen, Jorde, Anne Tomine, Cuenca-Estrella, Manuel, Hauser, Philippe M., Shrief, Raghdaa, Huerre, Michel, Freiberger, Tomas, Gaustad, Peter, Rodriguez-Tudela, Juan-Luis, Bille, Jacques, Denning, David W., Bretagne, Ste´phane, and Lortholary, Olivier

Abstract

ABSTRACTThe present study was performed to assess the interlaboratory reproducibility of the molecular detection and identification of species of Zygomycetesfrom formalin-fixed paraffin-embedded kidney and brain tissues obtained from experimentally infected mice. Animals were infected with one of five species (Rhizopus oryzae, Rhizopus microsporus, Lichtheimia corymbifera, Rhizomucor pusillus, and Mucor circinelloides). Samples with 1, 10, or 30 slide cuts of the tissues were prepared from each paraffin block, the sample identities were blinded for analysis, and the samples were mailed to each of seven laboratories for the assessment of sensitivity. A protocol describing the extraction method and the PCR amplification procedure was provided. The internal transcribed spacer 1 (ITS1) region was amplified by PCR with the fungal universal primers ITS1 and ITS2 and sequenced. As negative results were obtained for 93% of the tissue specimens infected by M. circinelloides, the data for this species were excluded from the analysis. Positive PCR results were obtained for 93% (52/56), 89% (50/56), and 27% (15/56) of the samples with 30, 10, and 1 slide cuts, respectively. There were minor differences, depending on the organ tissue, fungal species, and laboratory. Correct species identification was possible for 100% (30 cuts), 98% (10 cuts), and 93% (1 cut) of the cases. With the protocol used in the present study, the interlaboratory reproducibility of ITS sequencing for the identification of major Zygomycetesspecies from formalin-fixed paraffin-embedded tissues can reach 100%, when enough material is available.

Published
2010
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