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Your search keyword '"Jornada, Luciano K."' showing total 24 results
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24 results on '"Jornada, Luciano K."'

14. Lithium and valproate act on the GSK-3β signaling pathway to reverse manic-like behavior in an animal model of mania induced by ouabain

Author

Valvassori, Samira S., primary, Dal-Pont, Gustavo C., additional, Resende, Wilson R., additional, Jornada, Luciano K., additional, Peterle, Bruna R., additional, Machado, Alessandra Gonçalves, additional, Farias, Hemelin Resende, additional, de Souza, Claudio T., additional, Carvalho, André F., additional, and Quevedo, João, additional

Published
2017
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16. Decreased BDNF levels in amygdala and hippocampus after intracerebroventricular administration of ouabain

Author

Jornada, Luciano K., Valvassori, Samira S., Resende, Wilson R., Moretti, Morgana, Ferreira, Camila L., Fries, Gabriel R., Kapczinski, Flavio, and Quevedo, João

Subjects
BDNF, mania, nervous system, Na/K ATPase, ouabain, ouabaína
Abstract

OBJECTIVE: The present study aims to investigate the effects of ouabain intracerebroventricular injection on BDNF levels in the amygdala and hippocampus of Wistar rats. METHODS: Animals received a single intracerebroventricular injection of ouabain (10-3 and 10-2 M) or artificial cerebrospinal fluid and immediately, 1h, 24h, or seven days after injection, BDNF levels were measured in the rat's amygdala and hippocampus by sandwich-ELISA (n = 8 animals per group). RESULTS: When evaluated immediately, 3h, or 24h after injection, ouabain in doses of 10-2 and 10-3 M does not alter BDNF levels in the amygdala and hippocampus. However, when evaluated seven days after injection, ouabain in 10-2 and 10-3 M, showed a significant reduction in BDNF levels in both brain regions evaluated. DISCUSSION: In conclusion, we propose that the ouabain decreased BDNF levels in the hippocampus and amygdala when assessed seven days after administration, supporting the Na/K ATPase hypothesis for bipolar illness. OBJETIVO: O presente estudo tem como objetivo investigar os efeitos da injeção intracerebroventricular de ouabaína sobre os níveis de BDNF na amígdala e no hipocampo de ratos Wistar. MÉTODOS: Os animais receberam uma única injeção intracerebroventricular de ouabaína (10-3 and 10-2 M) ou fluido cerebroespinhal artificial e, imediatamente, 3h, 24h ou sete dias após a injeção, os níveis de BDNF foram mensurados na amígdala e hipocampo dos ratos por ELISA sandwich (n = 8 animais por grupo). RESULTADOS: Quando avaliados imediatamente após a injeção, 3h ou 24h, ouabaína nas doses 10-2 e 10-3 M não alterou os níveis de BDNF em ambas as estruturas avaliadas. Entretanto, quando avaliados sete dias após a injeção, ouabaína nas doses 10-2 e 10-3 M mostrou uma significante redução nos níveis de BDNF em amígdala e hipocampo. CONCLUSÃO: Em conclusão, propõe-se que a administração de ouabaína diminuiu os níveis de BDNF em amígdala e hipocampo quando avaliados sete dias após a injeção, suportando a hipótese da participação da Na/K ATPase no transtorno bipolar.

Published
2012

17. Folic acid prevented cognitive impairment in experimental pneumococcal meningitis

Author

Barichello, Tatiana, primary, Generoso, Jaqueline S., additional, Simões, Lutiana R., additional, Steckert, Amanda V., additional, Moreira, Ana Paula, additional, Dominguini, Diogo, additional, Ferrari, Pâmela, additional, Gubert, Carolina, additional, Kapczinski, Flávio, additional, Jornada, Luciano K., additional, Danielski, Lucineia G., additional, Petronilho, Fabricia, additional, Budni, Josiane, additional, and Quevedo, João, additional

Published
2014
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19. Anxiety disorders are associated with quality of life impairment in patients with insulin-dependent type 2 diabetes: a case-control study

Author

dos Santos, Maria Augusta B., primary, Ceretta, Luciane B., additional, Réus, Gislaine Z., additional, Abelaira, Helena M., additional, Jornada, Luciano K., additional, Schwalm, Mágada T., additional, Neotti, Morgana V., additional, Tomazzi, Cristiane D., additional, Gulbis, Karina G., additional, Ceretta, Renan A., additional, and Quevedo, João, additional

Published
2014
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20. DNA damage after intracerebroventricular injection of ouabain in rats

Author

Jornada, Luciano K., primary, Valvassori, Samira S., additional, Arent, Camila O., additional, Leffa, Daniela, additional, Damiani, Adriani A., additional, Hainzenreder, Giana, additional, Ferreira, Camila L., additional, Moretti, Morgana, additional, Andrade, Vanessa M., additional, and Quevedo, João, additional

Published
2010
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21. DARPP-32 expression in rat brain after electroconvulsive stimulation

Author

Rosa, Daniela V.F., primary, Souza, Renan P., additional, Souza, Bruno R., additional, Motta, Bernardo S., additional, Caetano, Fernando, additional, Jornada, Luciano K., additional, Feier, Gustavo, additional, Gomez, Marcus V., additional, Quevedo, João, additional, and Romano-Silva, Marco A., additional

Published
2007
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23. NCS-1 Expression in Rat Brain after Electroconvulsive Stimulation

Author

Rosa, Daniela V. F., primary, Souza, Renan P., additional, Souza, Bruno R., additional, Motta, Bernardo S., additional, Caetano, Fernando, additional, Jornada, Luciano K., additional, Feier, Gustavo, additional, Jeromin, Andreas, additional, Gomez, Marcus V., additional, Quevedo, João, additional, and Romano-Silva, Marco A., additional

Published
2006
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24. Anxiety disorders are associated with quality of life impairment in patients with insulin-dependent type 2 diabetes: a case-control study.

Author

Santos MA, Ceretta LB, Réus GZ, Abelaira HM, Jornada LK, Schwalm MT, Neotti MV, Tomazzi CD, Gulbis KG, Ceretta RA, and Quevedo J

Subjects
Anxiety Disorders physiopathology, Case-Control Studies, Diabetes Mellitus, Type 1 physiopathology, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 physiopathology, Female, Humans, Insulin therapeutic use, Male, Marital Status, Multivariate Analysis, Social Environment, Socioeconomic Factors, Surveys and Questionnaires, Anxiety Disorders psychology, Diabetes Mellitus, Type 1 psychology, Hypoglycemic Agents therapeutic use, Quality of Life psychology
Abstract

Objective: To assess the presence of anxiety disorders and quality of life in patients with insulin-dependent type 2 diabetes., Methods: Case-control study of 996 patients with type 2 diabetes and 2,145 individuals without diabetes. The sole inclusion criterion for the case group was insulin-dependent type 2 diabetes. We compared the case and control groups for sociodemographic variables, laboratory and clinical data, and presence of anxiety disorders. Quality of life was evaluated using the WHOQOL-BREF instrument, and the prevalence of anxiety disorder was evaluated by the Mini International Neuropsychiatric Interview (MINI)., Results: Patients with diabetes had a higher prevalence of generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder. The presence of these disorders in combination with type 2 diabetes was associated with worse quality of life in the physical, social, psychological, and environmental domains., Conclusions: This study demonstrates the importance of diagnosing and treating anxiety disorders in patients with diabetes, so as to prevent more serious complications associated with these comorbidities.

Published
2014
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