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Your search keyword '"Jorquera, Audrey"' showing total 12 results
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12 results on '"Jorquera, Audrey"'

2. Epidermal gamma delta T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult

Author

Gentek, Rebecca, Ghigo, Clement, Hoeffel, Guillaume, Jorquera, Audrey, Msallam, Rasha, Wienert, Stephan, Klauschen, Frederick, Ginhoux, Florent, Bajenoff, Marc, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
integumentary system, [SDV.IMM]Life Sciences [q-bio]/Immunology
Abstract

The murine epidermis harbors two immune cell lineages, Langerhans cells (LCs) and gamma delta T cells known as dendritic epidermal T cells (DETCs). LCs develop from both early yolk sac (YS) progenitors and fetal liver monocytes before locally self-renewing in the adult. For DETCs, the mechanisms of homeostatic maintenance and their hematopoietic origin are largely unknown. Here, we exploited multicolor fate mapping systems to reveal that DETCs slowly turn over at steady state. Like for LCs, homeostatic maintenance of DETCs is achieved by clonal expansion of tissue-resident cells assembled in proliferative units. The same mechanism, albeit accelerated, facilitates DETC replenishment upon injury. Hematopoietic lineage tracing uncovered that DETCs are established independently of definitive hematopoietic stem cells and instead originate from YS hematopoiesis, again reminiscent of LCs. DETCs thus resemble LCs concerning their maintenance, replenishment mechanisms, and hematopoietic development, suggesting that the epidermal microenvironment exerts a lineage-independent influence on the initial seeding and homeostatic maintenance of its resident immune cells.

Published
2018

7. Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery

Author

Ardouin, Laurence, primary, Luche, Hervé, additional, Chelbi, Rabie, additional, Carpentier, Sabrina, additional, Shawket, Alaa, additional, Montanana Sanchis, Frédéric, additional, Santa Maria, Camille, additional, Grenot, Pierre, additional, Alexandre, Yannick, additional, Grégoire, Claude, additional, Fries, Anissa, additional, Vu Manh, Thien-Phong, additional, Tamoutounour, Samira, additional, Crozat, Karine, additional, Tomasello, Elena, additional, Jorquera, Audrey, additional, Fossum, Even, additional, Bogen, Bjarne, additional, Azukizawa, Hiroaki, additional, Bajenoff, Marc, additional, Henri, Sandrine, additional, Dalod, Marc, additional, and Malissen, Bernard, additional

Published
2016
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11. Multicolor fate mapping of Langerhans cell homeostasis

Author

Ghigo, Clément, primary, Mondor, Isabelle, additional, Jorquera, Audrey, additional, Nowak, Jonathan, additional, Wienert, Stephan, additional, Zahner, Sonja P., additional, Clausen, Björn E., additional, Luche, Hervé, additional, Malissen, Bernard, additional, Klauschen, Frederick, additional, and Bajénoff, Marc, additional

Published
2013
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