Search

Objective: To address the lack of information about clinical sequelae of coronavirus disease 2019 (COVID-19). Patients and Methods: Previously hospitalized COVID-19 patients who were attending the outpatient clinic for post–COVID-19 patients (ASST Ovest Milanese, Magenta, Italy) were included in this retrospective study. They underwent blood draw for complete blood count, C-reactive protein, ferritin, D-dimer, and arterial blood gas analysis and chest high-resolution computed tomography (HRCT) scan. The primary endpoint was the assessment of blood gas exchanges after 3 months. Other endpoints included the assessment of symptoms and chest HRCT scan abnormalities and changes in inflammatory biomarkers after 3 months from hospital admission. Results: Eighty-eight patients (n = 65 men; 73.9%) were included. Admission arterial blood gas analysis showed hypoxia and hypocapnia and an arterial partial pressure of oxygen/fractional inspired oxygen ratio of 271.4 (interquartile range [IQR]: 238-304.7) mm Hg that greatly improved after 3 months (426.19 [IQR: 395.2-461.9] mm Hg, P

Background Chest radiography is universally accepted as the method of choice to confirm correct positioning of a nasogastric tube (NGT). Considering also that radiation exposure could increase with multiple insertions in a single patient, bedside abdominal ultrasound (BAU) may be a potentially useful alternative to chest radiography in the management of NGTs. Research Question What is the accuracy of BAU in confirming the correct positioning of an NGT? Study Design and Methods After a specific course consisting of 10 h of training, the authors studied, in a prospective multicenter cohort, the validity of BAU to confirm correct NGT placement. All patients were also evaluated by auscultation (whoosh test) and by chest radiography. Every involved operator was blind to each other. Interobserver agreement and accuracy analyses were calculated. Results This study evaluated 606 consecutive inpatients with an indication for NGT insertion. Eighty patients were excluded for protocol violation or incomplete examinations and 526 were analyzed. BAU was positive, negative, and inconclusive in 415 (78.9%), 71 (13.5%), and 40 (7.6%), respectively. The agreement between BAU and chest radiography was excellent. Excluding inconclusive results, BAU had a sensitivity of 99.8% (99.3%-100%), a specificity of 91.0% (88.5%-93.6%), a positive predictive value of 98.3% (97.2%-99.5%), and a negative predictive value of 98.6% (97.6%-99.7%). The accuracy of BAU slightly changed according to the different assignments of the uncertain cases and was improved by the exclusion of patients with an altered level of consciousness. Interpretation These results suggest that BAU has a good positive predictive value and may confirm the correct placement of NGTs when compared with chest radiography. However, considering its suboptimal specificity, caution is necessary before implementing this technique in clinical practice.

Highlights • There is no evidence that people who have recovered from coronavirus disease 2019 (COVID-19) are protected from a second infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). • People who have recovered from COVID-19 have antibodies to the virus. • No study has evaluated whether the presence of antibodies to SARS-CoV-2 confers immunity to second infection. • Our clinical observation showed that, at least in the short term, reinfection is very unlikely and any antibody immunity protects against recurrence., Background Most studies on SARS-CoV-2 infection show that people who have recovered from COVID-19 have antibodies to the virus. No study has evaluated whether the presence of antibodies to SARS-CoV-2 confers immunity to the infection relapse but however, to date, no human reinfections with SARS-CoV-2 have been confirmed. Material and methods In our prospective, multicenter, cohort study we investigated within three months all patients, with confirmed COVID-19, discharged from two Hospitals (Legnano and Magenta Hospitals), in an area of Italy severely affected by the infection. Telephone follow-up at 1 and 2 months and clinical contact within 3 months was initiated; demographic, clinical, radiologic and laboratory data were recorded in electronic medical records and updated. Results Of 1081 patients involved, 804 (74.3%) were discharged alive. For all these patients we obtained follow-up data. At 1 and 2 months none has died and none has had any signs of recurrence of infectious at both telephone interview and clinical visit. Conclusion Our clinical observation have confirmed two basic points: the reinfection is very unlikely and any antibody immunity protects against recurrence, at least in the short term.

Chest radiography is universally accepted as the method of choice to confirm correct positioning of a nasogastric tube (NGT). Considering also that radiation exposure could increase with multiple insertions in a single patient, bedside abdominal ultrasound (BAU) may be a potentially useful alternative to chest radiography in the management of NGTs.What is the accuracy of BAU in confirming the correct positioning of an NGT?After a specific course consisting of 10 h of training, the authors studied, in a prospective multicenter cohort, the validity of BAU to confirm correct NGT placement. All patients were also evaluated by auscultation (whoosh test) and by chest radiography. Every involved operator was blind to each other. Interobserver agreement and accuracy analyses were calculated.This study evaluated 606 consecutive inpatients with an indication for NGT insertion. Eighty patients were excluded for protocol violation or incomplete examinations and 526 were analyzed. BAU was positive, negative, and inconclusive in 415 (78.9%), 71 (13.5%), and 40 (7.6%), respectively. The agreement between BAU and chest radiography was excellent. Excluding inconclusive results, BAU had a sensitivity of 99.8% (99.3%-100%), a specificity of 91.0% (88.5%-93.6%), a positive predictive value of 98.3% (97.2%-99.5%), and a negative predictive value of 98.6% (97.6%-99.7%). The accuracy of BAU slightly changed according to the different assignments of the uncertain cases and was improved by the exclusion of patients with an altered level of consciousness.These results suggest that BAU has a good positive predictive value and may confirm the correct placement of NGTs when compared with chest radiography. However, considering its suboptimal specificity, caution is necessary before implementing this technique in clinical practice.

Essentials Ultrasound elastography uses tissue deformation to assess the relative quantification of its elasticity. Compression and duplex ultrasonography may be unable to correctly determine the thrombus age. Ultrasound elastography may be useful to distinguish between acute and chronic deep vein thrombosis. The exact determination of the thrombus age could have both therapeutic and prognostic implications. BACKGROUND: Background Ultrasound elastography (UE) imaging is a novel sonographic technique that is commonly employed for relative quantification of tissue elasticity. Its applicability to venous thromboembolic events has not yet been fully established; in particular, it is unclear whether this technique may be useful in determining the age of deep vein thrombosis (DVT). Thus, the aim of this study was to assess the role of UE in distinguishing acute from chronic DVT. Methods Consecutive patients with a first unprovoked acute and chronic (3 months old) DVT of the lower limbs were analyzed. Patients with recurrent DVT or with a suspected recurrence were excluded. The mean elasticity index (EI) values of acute and chronic popliteal and femoral vein thrombosis were compared. The accuracy of the EI in distinguishing acute from chronic DVT was also assessed by measuring the sensitivity, specificity, positive and negative predictive values, and likelihood ratios. Results One-hundred and forty-nine patients (mean age 63.9 years, standard deviation 13.6; 73 males) with acute and chronic DVT were included. The mean EI of acute femoral DVT was higher than that of chronic femoral DVT (5.09 versus 2.46), and the mean EI of acute popliteal DVT was higher than that of chronic popliteal DVT (4.96 versus 2.48). An EI value of > 4 resulted in a sensitivity of 98.9% (95% confidence interval [CI] 93.3-99.9), a specificity of 99.1% (95% CI 94.8-99.9), a positive predictive value of 91.1% (95% CI 77.9-97.1), a negative predictive value of 98.6% (95% CI 91.3-99.9), a positive likelihood ratio of 13.23 (95% CI 93-653) and a negative likelihood ratio of 0.001 (95% CI 0.008-0.05) for acute DVT. Conclusions UE appears to be a promising technique for distinguishing between acute and chronic DVT. Larger prospective studies are warranted to confirm our preliminary findings.

This cross-sectional study explores the frequency of, and rationale for, US Food and Drug Administration approval of high-risk therapeutic medical devices not meeting pivotal study primary end points from 2016 through 2020.

Introduction : Pulmonary embolism (PE) prevalence in acute exacerbations of COPD is highly variable. Methods : To investigate the prevalence and risk factors of PE in patients hospitalized in Departments of Internal Medicine because of AECOPD and suspected PE we conducted a retrospective multicenter study in patients with an AECOPD undergoing chest angio-computed tomography (angio-CT) because of clinical suspect of PE. Results 1043 patients (mean age 75.8 years ± 9.7 years, 34.5 % women) were included; 132 patients had PE (mean prevalence 12.66%, 95% confidence interval 10.73, 14.77%).) confirmed by angio-CT and 54 patients died during hospitalization (5.18 %). At multivariate analysis, age, female gender, clinical signs and symptoms suggestive of deep vein thrombosis, hypertension, PaCO2 ≤ 40 mmHg, and normal chest-x-ray were significantly associated with a higher PE prevalence. Prevalence of PE in patients with 0, 1, 2, 3 or ≥4 risk factors progressively increase from 1.76 to 30.43%. Mean length of hospitalization (LOH) (15.7 vs 14.2 days, p 0.07) and in-hospital mortality (6.1% vs 5.1%, P=0.62) were slightly but not significantly higher in in patients with PE (6.1% vs 5.1%, P=0.62). Conclusions : PE prevalence is not negligible in this setting. A number of risk factors may help clinicians in identification of patients at increased risk of PE.

Although myocarditis can be a severe cardiac complication of COVID-19 patients, few data are available in the literature about the incidence and clinical significance in patients affected by SARS-CoV-2. This study aims to describe the prevalence and the clinical features of suspected myocarditis in 3 cohorts of patients hospitalized for COVID-19. We retrospectively evaluated all the consecutive patients admitted for COVID-19 without exclusion criteria. Suspect myocarditis was defined according to current guidelines. Age, sex, in-hospital death, length of stay, comorbidities, serum cardiac markers, interleukin-6, electrocardiogram, echocardiogram, and therapy were recorded. Between March 4 to May 20, 2020, 1169 patients with COVID-19 were admitted in 3 Italian Medicine wards. 12 patients (1%) had suspected acute myocarditis; 5 (41.7%) were men, mean age was 76 (SD 11.34; median 78.5 years); length of stay was 38 days on average (SD 8, median value 37.5); 3 (25%) patients died. 8 (66.7%) had a history of cardiac disease; 7 (58.33%) patients had other comorbidities like diabetes, chronic obstructive pulmonary disease, or renal insufficiency. Myocarditis patients had no difference in sex prevalence, rate of death, comorbidities, elevations in serum cardiac markers as compared with patients without myocardial involvement. Otherwise, there was a significantly higher need for oxygen-support and a higher prevalence of cardiac disease in the myocarditis group. Patients with suspected myocarditis were older, had a higher frequency of previous cardiac disease, and significantly more prolonged hospitalization and a lower value of interleukin-6 than other COVID-19 patients. Further studies, specifically designed on this issue, are warranted.

Elderly patients admitted to the hospital are at increased risk for both in-hospital and post-discharge mortality. Risk assessment models (RAMs) for in-hospital mortality are based mainly on physiological variables and a few laboratory data, whereas RAMs for late mortality usually include other domains such as disability and comorbidities. We aim to evaluate if a previous validated model for 1-year mortality (the Walter Score) would also work well in predicting in-hospital mortality. We retrospectively revised the medical records of patients admitted on our ward, from April to December, 2013. Data regarding gender, activities of daily living (ADLs), comorbidities, and routine laboratory tests were used to calculate a Modified Walter Score (MoWS). The main outcome measure was all cause, in-hospital mortality. The analysis involved 1,004 patients. Of these, 888 were discharged alive, and 116 (11.5 %) died during the hospitalization. The mean MoWS was 4.9 (±3.6) in the whole sample. Stratification into risk classes parallels with in-hospital mortality (Chi square for trend p < 0.001). When dichotomized, MoWS has a sensitivity of 97.4 % (95 % CI 92.1-99.3), and a specificity of 48.2 % (95 % CI 44.9-51.5) with a good prognostic accuracy (area under the ROC = 0.81; 95 % CI 0.78, 0.84). Subgroup analysis according to different age groups gives similar results. A simple RAM based on multiple domains, previously validated for predicting mortality of older adults within 1 year from the index hospitalization, can be useful at the moment of admission to Internal Medicine wards to accurately identify patients at low risk of in-hospital mortality.

Atrial fibrillation is the most common arrhythmia in over-midlife patients. In addition to systolic heart failure, cerebral thromboembolism represents the most dramatic complication of this rhythm disorder, contributing to morbidity and mortality. Traditionally, anticoagulation has been considered the main strategy in preventing stroke and systemic embolism in atrial fibrillation patients and vitamin K-dependent antagonists have been widely used in clinical practice. Recently, the development of direct oral anticoagulants has certainly improved the management of this disease, providing, for the first time, the opportunity to go beyond vitamin K-dependent antagonists limits. In the RE-LY trial, dabigatran 150 mg twice daily was superior to warfarin in the prevention of stroke or systemic embolism and dabigatran 110 mg twice daily was noninferior. Both doses greatly reduced hemorrhagic stroke, and dabigatran 110 mg twice daily significantly reduced major bleeding compared with warfarin. Based on these results, dabigatran, a direct thrombin inhibitor, was the first direct oral anticoagulant to receive the regulatory approval for nonvalvular atrial fibrillation patients. To date, a specific reversal agent has just been approved as an antidote for this molecule. This review provides a summary of randomized trials, postmarket registries and specific clinical-settings summary on dabigatran in nonvalvular atrial fibrillation.

SummaryBackground Compression ultrasonography (CUS) has been recognized as the diagnostic procedure of choice for the investigation of patients with suspected deep vein thrombosis (DVT); the aim of this study was to assess the diagnostic accuracy of nurse-performed CUS for symptomatic proximal DVT of the lower limb. Material and Methods We prospectively evaluated all consecutive outpatients referred for suspected DVT from January 2011 to December 2012. All patients underwent bilateral proximal lower limb CUS, first by trained nurses and then by physicians expert in vascular ultrasonography, with every group blinded with respect to each other. This test was repeated after 5–7 days in all negative or unclear examinations. Interobserver agreement and accuracy of nurse-performed CUS were calculated, considering the physician's final diagnosis as the reference test. Results Six hundred ninety-seven patients were included in the study. DVT was diagnosed in 122 patients by expert ultrasound physicians with an overall prevalence of 17.5% (95% confidence interval [CI] 15.8%–20.6%). Nurse agreement with the physician in DVT diagnosis was excellent (Cohen's κ 0.82, 95% CI 0.79–0.85). Nurse-performed CUS had a sensitivity of 84.4% (95% CI 81.7%–87.1%) and a specificity of 97.0% (95% CI 95.8%–98.3%) with a diagnostic accuracy of 94.8% (95% CI 93.2%–96.5%). Conclusion Our results suggest that nurse-performed CUS may be a potential useful alternative to physician performed CUS with a good accuracy. However, sensibility of nurse-performed CUS appeared suboptimal and future studies should incorporate in the evaluation of this technique other pretest tools that may increase its accuracy.

BACKGROUND Patients with suspected deep vein thrombosis (DVT) of the lower limb represent a diagnostic dilemma for general practitioners. Compression ultrasonography (US) is universally recognized as the best test of choice. We assessed the diagnostic accuracy of compression US performed by general practitioners given short training in the management of symptomatic proximal DVT. METHODS From May 2014 to May 2016, we evaluated in a multicenter, prospective cohort study all consecutive outpatients with suspected DVT; bilateral proximal lower limb compression US was performed by general practitioners and by physicians expert in vascular US, each group blinded to the other’s findings. In all examinations with a negative or nondiagnostic result, compression US was repeated by the same operator after 5 to 7 days. Inter-observer agreement and accuracy were calculated. RESULTS We enrolled a total of 1,107 patients. The expert physicians diagnosed DVT in 200 patients, corresponding to an overall prevalence of 18.1% (95% CI, 15.8%–20.3%). The agreement between the trained general practitioners and the experts was excellent (Cohen κ = 0.86; 95% CI, 0.84–0.88). Compression US performed by general practitioners had a sensitivity of 90.0% (95% CI, 88.2%–91.8%) and a specificity of 97.1% (95% CI, 96.2%–98.1%) with a diagnostic accuracy for DVT of 95.8% (95% CI, 94.7%–97.0%). CONCLUSIONS Our results suggest that, even in hands of physicians not expert in vascular US, compression US can be a reliable tool in the diagnosis of DVT. We found that the sensitivity achieved by general practitioners appeared suboptimal, however, so future studies should evaluate the implementation of proper training strategies to maximize skill.

In clinical practice lung ultrasound (LUS) is becoming an easy and reliable noninvasive tool for the evaluation of dyspnea. The aim of this study was to assess the accuracy of nurse-performed LUS, in particular, in the diagnosis of acute cardiogenic pulmonary congestion. We prospectively evaluated all the consecutive patients admitted for dyspnea in our Medicine Department between April and July 2014. At admission, serum brain natriuretic peptide (BNP) levels and LUS was performed by trained nurses blinded to clinical and laboratory data. The accuracy of nurse-performed LUS alone and combined with BNP for the diagnosis of acute cardiogenic dyspnea was calculated. Two hundred twenty-six patients (41.6% men, mean age 78.7 ± 12.7 years) were included in the study. Nurse-performed LUS alone had a sensitivity of 95.3% (95% CI: 92.6-98.1%), a specificity of 88.2% (95% CI: 84.0-92.4%), a positive predictive value of 87.9% (95% CI: 83.7-92.2%) and a negative predictive value of 95.5% (95% CI: 92.7-98.2%). The combination of nurse-performed LUS with BNP level (cut-off 400 pg/mL) resulted in a higher sensitivity (98.9%, 95% CI: 97.4-100%), negative predictive value (98.8%, 95% CI: 97.2-100%), and corresponding negative likelihood ratio (0.01, 95% CI: 0.0, 0.07). Nurse-performed LUS had a good accuracy in the diagnosis of acute cardiogenic dyspnea. Use of this technique in combination with BNP seems to be useful in ruling out cardiogenic dyspnea. Other studies are warranted to confirm our preliminary findings and to establish the role of this tool in other settings.

Identification and quantification higher risk incidence of aortic rupture or dissection (AARD) could be of clinical interest and improve preventive strategies.Several studies and subsequent meta-analyses have shown chronobiologic variations in the timing of occurrence of myocardial infarction, stroke, and pulmonary embolism. Conversely, such evidences are currently lacking for AARD despite a number of studies available dealing with periodicity.MEDLINE, EMBASE, and Google Scholar databases were searched up to July 2013. Temporal variation in the incidence of AARD was analyzed including all studies analyzing seasonal, monthly, weekly, and circadian aggregations. Two authors independently reviewed and extracted data.Forty-two studies for a total of more than 80 000 patients were included. Our results showed a significantly increased incidence of AARD in Winter (Chi-square 854.92, p 0.001), with a relative risk (RR) of 1.171 (99% CI 1.169, 1.172), in December (Chi-square 361.03, p 0.001), RR of 1.142 (99% CI 1.141, 1.143), on Monday (Chi-square 428.09, p 0.001), RR of 1.214 (99% CI 1.211, 1.216), and in the hours between 6 am and 12 pm (Chi-square 212.02, p 0.001), RR of 1.585 (99% CI 1.562, 1.609). Subgroup and sensitivity analyses confirmed the results of principal analyses.Our data strongly support the presence of evident rhythmic patterns in the incidence of acute aortic events, characterized by significantly higher risk in Winter, in December, on Monday and between 6 am and 12 pm. Future studies are needed to better clarify the underlying mechanisms and clinical implications.

Learning Point for Clinicians Hypoplasia of the inferior vena cava (IVC) has been described mainly as an incidental finding associated with a number of congenital malformations; it should be taken into account when otherwise unexplained deep vein thrombosis (DVT) develops in young people; tips for diagnosis are the presence of extensive and bilateral iliac thrombosis and an enlarged shadow of the azygos vein on chest X-rays, computed tomography (CT) and magnetic resonance imaging (MRI). A 61-year-old man presented with spontaneous bilateral ilio-femoral DVT and dyspnea. His past medical history was unremarkable, and there was no familial history for venous …

A 76-year-old, female, non-smoker developed all the spectrum of dermatological reactions 2 months after receiving erlotinib (150 mg daily) for advanced non-small cell lung cancer and known epidermal growth-factor receptor (EGFR) mutation. Her face had a papulopustular rash with erythematous and dry skin; trichomegaly (elongation and curling of the eyelashes), blepharitis and fine and brittle hair were also seen (Figure 1); finally, there was also periungual inflammation with …

A 61-year-old who was receiving long-term treatment with prednisone for refractory idiopathic thrombocytopenic purpura required a dose increase after a large decrease in platelet count (6×109/L). He had had his spleen removed 7 years earlier. He was not on any other medication and there was no evidence of pseudot hrombocytopenia, lymphoprolipherative disease, malig nancies, or Mycobacterium tuberculosis infection. Serological tests were negative for HIV, Epstein Barr virus, cytomegalovirus, antinuclear antibodies, and lupus anticoagulant. Stool specimen was negative for Helicobacter pylori. 24 h later he developed pigmented vesicles on the left side of his trunk, left arm, and left hand. Segmental distribution of the painful cutaneous lesions suggested haemorrhagic herpes zoster. Prednisone was stopped and the patient was treated with intravenous immunoglobulin G (1 g/kg daily for 4 days) and valacyclovir (1 g three times daily). He had a rapid increase in platelet count and uneventful recovery. Haemorrhagic herpes zoster is an atypical form of cutaneous varicella zoster virus and correlates with immunodepression, coagulopathy, or thrombocytopenia.

Recurrent deep venous thrombosis despite well conducted anticoagulant treatment is an uncommon, but possible, event. It has been hypothesized that overt hyperthyroidism may increase thromboembolic risk. We present the case of an elderly man with a recurrent episode of deep venous thrombosis during optimal oral vitamin K antagonist treatment, associated with a new diagnosis of overt hyperthyroidism, with no evidence of occult cancer and normal levels of antiphosholipid antibodies.

A 77-year-old woman was complaining of pain in the scapular cingulum since 3 months and pain and swelling in both the wrists, with elevated CRP. She began therapy with deflazacort, bisphosphonates and vitamin D. After a month the patient complained of frontal and bitemporal headache. Shortly after, the patient had intense onset pain in the tongue and …

Frontal meningiomas may present only with psychological symptoms that resemble depression, anxiety states, hypomania and schizophrenia. Herein, we present the case of a 55-year-old man who was initially thought to have depression and bipolar disorder, but was eventually diagnosed with frontal lobe syndrome caused by a giant frontal meningioma.

Learning Point for Clinicians The most frequent causes of spontaneous pericardial tamponade are neoplastic invasion; pericardial involvement by Hodgkin lymphoma is usually asymptomatic unless accompanied by substantial pericardial effusion. Herein, we report an unusual case of recurrent cardiac tamponade in a patient with nodular sclerosis Hodgkin disease (HD) that was successfully treated with repeated pericardiocentesis and chemotherapy with an excellent outcome. A 23-year-old man was recently diagnosed with nodular sclerosis HD, Cotswold stage II-B. While awaiting chemotherapy, he presented with new-onset dyspnea and jugular turgor. On physical examination, he had evidence of pulsus paradoxus and quiet heart; his blood pressure was 83/65 mm Hg. Electrocardiogram showed low QRS voltages with electrical alternans (Figure 1A, arrows). Transthoracic echocardiography revealed severe pericardial effusion with diastolic collapse of the right and …

Summary. Background: Compression ultrasonography(CUS) has been recognized as the diagnostic procedure ofchoice for the investigation of patients with suspecteddeep vein thrombosis (DVT); the aim of this study was toassess the diagnostic accuracy of nurse-performed CUSfor symptomatic proximal DVT of the lower limb. Mate-rial and Methods: We prospectively evaluated all consecu-tive outpatients referred for suspected DVT from January2011 to December 2012. All patients underwent bilateralproximal lower limb CUS, first by trained nurses andthen by physicians expert in vascular ultrasonography,with every group blinded with respect to each other. Thistest was repeated after 5–7 days in all negative or unclearexaminations. Interobserver agreement and accuracy ofnurse-performed CUS were calculated, considering thephysician’s final diagnosis as the reference test. Results:Six hundred ninety-seven patients were included in thestudy. DVT was diagnosed in 122 patients by expertultrasound physicians with an overall prevalence of17.5% (95% confidence interval [CI] 15.8%–20.6%).Nurse agreement with the physician in DVT diagnosiswas excellent (Cohen’s j 0.82, 95% CI 0.79–0.85). Nurse-performed CUS had a sensitivity of 84.4% (95% CI81.7%–87.1%) and a specificity of 97.0% (95% CI95.8%–98.3%) with a diagnostic accuracy of 94.8% (95%CI 93.2%–96.5%). Conclusion: Our results suggest thatnurse-performed CUS may be a potential useful alterna-tive to physician performed CUS with a good accuracy.However, sensibility of nurse-performed CUS appearedsuboptimal and future studies should incorporate in theevaluation of this technique other pretest tools that mayincrease its accuracy.Keywords: diagnostic tests; Doppler ultrasonography;nurses; vascular diseases; venous thrombosis.IntroductionPrompt diagnosis of deep vein thrombosis (DVT) isessential to decrease the risk of potentially fatal pulmo-nary embolism and postthrombotic syndrome inuntreated patients [1,2]. Diagnostic strategies in DVTshould be accurate, simple to apply, and cost effective.Currently, compression ultrasonography (CUS) is consid-ered the method of choice for the diagnosis of DVT insymptomatic patients, and its use has been validated inseveral prospective studies [2–4]. The potential advantagesof this technique are the ease of performance by manyoperators and the availability in many hospitals with vir-tually all ultrasound scanners, regardless of generation,model, and even probe frequency [5].Although CUS has shown good accuracy for the diag-nosis of symptomatic proximal DVT, its specificity andsensitivity for calf vein thrombi are much lower [2,4]. Forthis reason, CUS may be limited to the proximal veinsand repeated within 1 week when negative (serial proxi-mal CUS) or extended to both proximal and distal veinsand performed on a single occasion with color-Dopplersupport (whole-leg ultrasonography) [2,5]; both strategiesare reliable diagnostic options for the management ofthese patients [2,5].

• Isolated left ventricular non-compaction (LVNC) has recently emerged due to widespread use of noninvasive cardiac imaging.

OC-01 Prognostic relevance of asymptomatic venous thromboembolism in patients with cancer F. Dentali *, W. Ageno, M. Giorgi Pierfranceschi, D. Imberti, A. Malato, C. Nitti, A. Salvi, S. Siragusa, A. Squizzato, A. Venco, J. Vitale, G. Agnelli. Department of Clinical Medicine, Insubria University, Varese, Emergency Department, Thrombosis Center, Hospital of Piacenza, Department of Hematology, University of Palermo, Clinical Medicine, Hospital of Ancona, Department of Vascular and Internal Medicine, University of Perugia, Italy