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1. Prótesis sin sutura: ¿es posible reducir la tasa de bloqueos postoperatorios modificando la técnica de implante?

Author: Miguel González-Barbeito, Patricia Pardo-Martinez, Francisco Estévez-Cid, Carlos Velasco-García de Sierra, Jorge Rodriguez-Garrido, Yago Vilela-González, María García-Vieites, Laura Fernández-Arias, Carmen Iglesias-Gil, Victor X. Mosquera-Rodriguez, Jose María Herrera-Noreña, and José J. Cuenca-Castillo
Subjects: Medicine, Surgery, RD1-811
Abstract: Resumen: Introducción: El recambio valvular aórtico con prótesis sin sutura Perceval S se asocia a un aumento en la tasa de bloqueo auriculoventricular postoperatorio que precisa implante de marcapasos definitivo, comparado con las bioprótesis convencionales. En nuestra serie hemos modificado la técnica de implante (mínimo baloneo
Published: 2018
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2. Anillo mitral asimétrico en la corrección de la insuficiencia mitral isquémica crónica: resultados clínicos y predictores ecocardiográficos de recidiva

Author: Carmen Iglesias-Gil, Francisco Estévez-Cid, Miguel González-Barbeito, Nemesio Alvarez, and José J. Cuenca-Castillo
Subjects: Insuficiencia mitral, Isquemia miocárdica, Reparación mitral, Medicine, Surgery, RD1-811
Abstract: Introducción y objetivos: La insuficiencia mitral (IM) isquémica crónica es una patología frecuente y compleja, consecuencia del remodelado ventricular y anular mitral asimétrico que acontece tras el infarto de miocardio. El anillo protésico Carpentier-McCarthy-Adams IMR ETlogix® (Edwards Lifesciences Corporation) actúa específicamente sobre esta deformación geométrica. Analizamos nuestros resultados tras 10 años realizando esta técnica. Métodos: Noventa pacientes con IM isquémica crónica grado ≥ 2 fueron sometidos consecutivamente a anuloplastia mitral con anillo IMR ETlogix® desde 2005 hasta 2015; 75 (83,3%) presentaban clase funcional NYHA III-IV. Sesenta y seis (73,3%) fueron intervenidos con carácter urgente. En 73 (81,1%) asociamos otro procedimiento cardíaco. Obtuvimos seguimiento clínico y ecocardiográfico periódico de todos los pacientes que superaron la cirugía. Resultados: Mediana de seguimiento 62 meses (12-129). Mortalidad hospitalaria de 1 paciente (1,1%); 16 pacientes fallecidos en el seguimiento (7 de causa cardíaca). El ecocardiograma de control tardío objetivó recidiva significativa (IM grado ≥ 2) en 6 pacientes (2 de ellos IM grado > 2), con una reintervención por dehiscencia anular. No hubo incremento significativo en el gradiente medio transmitral. El análisis univariado objetivó la altura de tenting preoperatoria como mejor predictor de recidiva de la IM en nuestra serie, con un punto de corte en 10,65 mm (sensibilidad 100%, especificidad 93%, área bajo la curva ROC 0,97). Conclusiones: La anuloplastia con anillo IMR ETlogix® es una técnica segura y eficaz para corregir la IM isquémica crónica, fundamentalmente en pacientes con una altura de tenting preoperatoria inferior a 10,65 mm.
Published: 2017
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3. Estudio de casos y controles de los factores de riesgo de mediastinitis en cirugía de revascularización miocárdica

Author: José María Gutiérrez-Urbón, María J. Pereira-Rodríguez, and José J. Cuenca-Castillo
Subjects: Mediastinitis, Cirugía de revascularización miocárdica, Factores de riesgo, Estudio de casos y controles, Medicine, Surgery, RD1-811
Abstract: Introducción y objetivos: La mediastinitis es una complicación de la cirugía de revascularización miocárdica (CRM) que causa elevada morbimortalidad. El objetivo del estudio es identificar los factores de riesgo de mediastinitis en CRM, con o sin cirugía cardíaca adicional, y los microorganismos implicados en esta infección. Método: Estudio de casos y controles retrospectivo en pacientes sometidos a CRM durante los años 2004 a 2008 en un hospital general de nivel terciario. Los casos fueron todos los pacientes con mediastinitis posquirúrgica. Se seleccionaron al azar y por proximidad temporal 2 controles por cada caso. Se registró la información de las variables a estudio mediante la revisión de historias clínicas, y se realizaron análisis univariables y multivariables. Resultados: Se registraron 73 mediastinitis en un total de 1.353 CRM (incidencia: 5,39%). En el modelo final de regresión logística, los factores de riesgo de mediastinitis identificados fueron: obesidad ≥ grado II (p = 0,004), cirujano (p = 0,004), insuficiencia renal (p = 0,006), estancia posquirúrgica en unidad de cuidados intensivos > 3 días (p = 0,019) y cirugía cardíaca adicional (p = 0,020). Los microorganismos aislados con más frecuencia fueron estafilococos, mayoritariamente Staphylococcus epidermidis (30,7%). Conclusiones: El cirujano que practica la intervención, la obesidad ≥ grado II, la insuficiencia renal, la cirugía cardíaca adicional y la estancia posquirúrgica en unidad de cuidados intensivos > 3 días fueron los factores de riesgo asociados a mediastinitis en pacientes sometidos a CRM.
Published: 2013
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4. Historia y desarrollo de la cirugía coronaria en España

Author: José J. Cuenca Castillo
Subjects: Medicine, Surgery, RD1-811
Published: 2023
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5. Ya nada es igual en la sustitución valvular aórtica

Author: José J. Cuenca Castillo
Subjects: Medicine, Surgery, RD1-811
Published: 2023
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6. Disección 'Esqueletizada' de la arteria mamaria interna: técnica básica en la revascularización arterial extendida

Author: José J. Cuenca Castillo
Subjects: Medicine, Surgery, RD1-811
Published: 2021
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7. Registro Español de Trasplante Cardiaco. XXXII Informe Oficial de la Asociación de Insuficiencia Cardiaca de la Sociedad Española de Cardiología

Author: Ana Pórtoles-Ocampo, José María Arizón del Prado, Laura Morán-Fernández, Manuel Martínez-Sellés, Luis García-Guereta Silva, Juan Carlos López-Azor, Álvarez González-Rocafort, Raquel López-Viella, Leticia Jimeno-San Martín, Javier Castrodeza, Miguel Llano-Cardenal, María Ángeles Castel, Gregorio Rábago-Juan-Aracil, Ferrán Gran-Ipiña, Francisco José Hernández-Pérez, Juan Delgado-Jiménez, José J. Cuenca-Castillo, Mónica Cebrián, Eduardo Zatarain, Gonzalo Barge-Caballero, Teresa Blasco-Peiró, M. Farrero, Isabel Zegrí, José González-Costello, Carlos Ortiz, María del Val Groba-Marco, Francisco González-Vílchez, Antonio García-Quintana, Pedro Caravaca, Francisco Nistal-Herrera, Víctor Donoso, Mercedes Rivas-Lasarte, María Dolores García-Cosío, Javier Tobar-Ruiz, Luis de la Fuente-Galán, Oscar Gonzalez-Fernandez, Nuria Gil-Villanueva, Rebeca Manrique-Antón, Laura López, Beatriz Díaz-Molina, Nicolás Manito, Luz Polo-López, José Luis Lambert-Rodríguez, Zorba Blázquez, Carlos Labrandero de Lera, Luis Almenar-Bonet, Carles Díez, Iago Sousa, Luis Martínez, Manuel Gómez-Bueno, José María Herrera-Noreña, María Lasala-Alastuey, Antonio Grande-Trillo, Vicens Brossa-Loidi, Iris P. Garrido-Bravo, Mario Galván-Ruiz, Paola Dolader, Inés Ponz de Antonio, Marta de Antonio, Paula Navas, Cristina Mitroi, Ignacio Sánchez-Lázaro, Amador López-Granados, Francisco J. Pastor-Pérez, Javier Segovia-Cubero, María Jesús Valero-Masa, Cristina Fidalgo-Muñiz, David Couto-Mallón, Domingo A. Pascual-Figal, María J. Paniagua-Martín, María G. Crespo-Leiro, Eduardo Barge-Caballero, José A. Vázquez de Prada, Diego Rangel-Sousa, Sol Martínez, José Manuel Sobrino-Márquez, Manuela Camino-López, Josep Roca, Elena García-Romero, Félix Pérez-Villa, Jorge García-Carreño, Sonia Mirabet-Pérez, Manuel Cobo-Belaustegui, and Miriam Juárez
Subjects: business.industry, Medicine, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen Introduccion y objetivos Se presentan las caracteristicas clinicas y los resultados de los trasplantes cardiacos realizados en Espana con la actualizacion correspondiente a 2019. Metodos Se describen las caracteristicas clinicas y los resultados de los trasplantes cardiacos realizados en 2019, asi como las tendencias de estos en el periodo 2010-2018. Resultados En 2019 se realizaron 300 trasplantes (8.794 desde 1984; 2.745 entre 2010 y 2019). Respecto a anos previos, los cambios mas llamativos son el descenso hasta el 38% de los trasplantes realizados en codigo urgente, y la consolidacion en el cambio de asistencia circulatoria pretrasplante, con la practica desaparicion del balon de contrapulsacion (0,7%), la estabilizacion del uso del oxigenador extracorporeo de membrana (9,6%) y el aumento de los dispositivos de asistencia ventricular (29%). La supervivencia en el trienio 2016-2018 es similar a la del trienio 2013-2015 (p = 0,34), y ambas mejores que la del trienio 2010-2012 (p = 0,002 y p = 0,01 respectivamente). Conclusiones Se mantienen estables tanto la actividad del trasplante cardiaco en Espana como los resultados en supervivencia en los ultimos 2 trienios. Hay una tendencia a realizar menos trasplantes urgentes, la mayoria con dispositivos de asistencia ventricular.
Published: 2021
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8. Initial Invasive or Conservative Strategy for Stable Coronary Disease

Author: Maron D. J., Hochman J. S., Reynolds H. R., Bangalore S., O'Brien S. M., Boden W. E., Chaitman B. R., Senior R., Lopez-Sendon J., Alexander K. P., Lopes R. D., Shaw L. J., Berger J. S., Newman J. D., Sidhu M. S., Goodman S. G., Ruzyllo W., Gosselin G., Maggioni A. P., White H. D., Bhargava B., Min J. K., John Mancini G. B., Berman D. S., Picard M. H., Kwong R. Y., Ali Z. A., Mark D. B., Spertus J. A., Krishnan M. N., Elghamaz A., Moorthy N., Hueb W. A., Demkow M., Mavromatis K., Bockeria O., Peteiro J., Miller T. D., Szwed H., Doerr R., Keltai M., Selvanayagam J. B., Gabriel Steg P., Held C., Kohsaka S., Mavromichalis S., Kirby R., Jeffries N. O., Harrell F. E., Rockhold F. W., Broderick S., Bruce Ferguson T., Williams D. O., Harrington R. A., Stone G. W., Rosenberg Y, ISCHEMIA Research Group: Joseph Ricci, A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Rabaça, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fernández Martínez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, André Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej Łabyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Peñaranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezińska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard Jäger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Carísi A Polanczyk, Carita Krannila, Carla Vicente, Carl-Éric Gagné, Carlo Briguori, Carlos Peña Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Björklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adrián Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnación Alonso-Álvarez, Eric Nicollet, Eric Peterson, Erick Alexánderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, F Marin Ortuño, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Flávia Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidović, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Lladó, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, Inês Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, João Reynaldo Abbud, João V Vitola, Joaquín V Peñafiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, José A Ortega-Ramírez, José Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Vieira, José M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padró, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio César Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna Łoboz-Grudzień, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kukuła, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura 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Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Valdés Chávarri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena Łanocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Małgorzta Celińska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Valério Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C 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Duarte, Tauqir Huk, Téodora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nuñez, Virginia Fernández-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-Ríos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek Pépin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
Subjects: Male, Cardiac Catheterization, Computed Tomography Angiography, medicine.medical_treatment, Myocardial Ischemia, Coronary Disease, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Coronary Angiography, ISCHEMIA Research Group, law.invention, Angina, Coronary artery disease, 0302 clinical medicine, Randomized controlled trial, law, Cardiovascular Disease, Myocardial Revascularization, 030212 general & internal medicine, Coronary Artery Bypass, 11 Medical and Health Sciences, Cardiac catheterization, General Medicine, Middle Aged, humanities, Cardiovascular Diseases, Cardiology, Female, Human, medicine.medical_specialty, Ischemia, Article, 03 medical and health sciences, Geriatric cardiology, Percutaneous Coronary Intervention, General & Internal Medicine, Internal medicine, medicine, Humans, Angina, Unstable, Aged, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Bayes Theorem, medicine.disease, Heart failure, Quality of Life, business
Abstract: BACKGROUND: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS: We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS: Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, -1.8 percentage points; 95% CI, -4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS: Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).
Published: 2020
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9. The "Skipping Rope" Phenomenon in Transapical TAVI as a Cause of Reversible Mitral Regurgitation

Author: Victor X, Mosquera, primary, Alberto, Bouzas-Mosquera, additional, and José J, Cuenca-Castillo, additional
Published: 2022
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10. Health status after invasive or conservative care in coronary and advanced kidney disease

Author: Spertus J. A., Jones P. G., Maron D. J., Mark D. B., O'Brien S. M., Fleg J. L., Reynolds H. R., Stone G. W., Sidhu M. S., Chaitman B. R., Chertow G. M., Hochman J. S., Bangalore S, ISCHEMIA-CKD Research Group: Abdallah M Abdallah, Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M 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H.R., Stone G.W., Sidhu M.S., Chaitman B.R., Chertow G.M., Hochman J.S., Bangalore S, and ISCHEMIA-CKD Research Group: Abdallah M Abdallah, Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew Starovoytov, Andrzej Łabyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-Éric Gagné, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Björklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnación Alonso-Álvarez, Eric Daugas, Erick Alexánderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Flávia Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, François Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, Inês Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jesús Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaquín V Peñafiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-Iñiguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, José A Ortega-Ramírez, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Costa Vieira, José M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, José Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel López Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio César Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, María Dolores Martínez-Ruíz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Shinseki, Matthew Weir, Maura Carina Nédio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdończyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar Méndiz, Óscar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula García-González, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe Généreux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jesús-Pérez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto René Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rubén Baleón-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth Pérez-Fernández, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, Sérgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, Sílvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, Téodora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fernández-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-Ríos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek Pépin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
Subjects: Male, Intention to Treat Analysi, medicine.medical_treatment, Health Status, Myocardial Ischemia, 030204 cardiovascular system & hematology, Coronary Angiography, law.invention, Health Statu, 0302 clinical medicine, Randomized controlled trial, law, Surveys and Questionnaires, Odds Ratio, Surveys and Questionnaire, 030212 general & internal medicine, Myocardial infarction, Coronary Artery Bypass, medicine.diagnostic_test, General Medicine, Middle Aged, Intention to Treat Analysis, Cardiology, Female, Human, medicine.medical_specialty, Revascularization, Follow-Up Studie, 03 medical and health sciences, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, cardiovascular diseases, Healthy Lifestyle, Renal Insufficiency, Chronic, Proportional Hazards Models, Aged, Intention-to-treat analysis, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Odds ratio, medicine.disease, Angiography, Exercise Test, Proportional Hazards Model, business, Kidney disease, Follow-Up Studies
Abstract: BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of
Published: 2020

11. Galectina-3 circulante tras el trasplante cardiaco: dinámica a largo plazo y valor pronóstico

Author: Jorge Pombo-Otero, Antoni Bayes-Genis, Lucía Moreda-Santamaría, Nieves Doménech, Francisco Estévez-Cid, Natalia Suárez-Fuentetaja, Javier Muñiz, María J. Paniagua-Martín, Miguel Solla-Buceta, María G. Crespo-Leiro, José J. Cuenca-Castillo, Eduardo Barge-Caballero, Z. Grille-Cancela, Gonzalo Barge-Caballero, David Couto-Mallón, Paula Blanco-Canosa, and José Manuel Vázquez-Rodríguez
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen Introduccion y objetivos Los valores plasmaticos de galectina-3 (Gal-3) estan elevados y se correlacionan con la mortalidad total y cardiovascular en pacientes con insuficiencia cardiaca, pero su correlacion con el pronostico tras el trasplante cardiaco (TxC) es desconocida. El objetivo fue describir la tendencia evolutiva y el valor pronostico de este biomarcador tras el TxC. Metodos Mediante enzimoinmunoensayo, se midieron las concentraciones plasmaticas de Gal-3 en muestras de suero de 122 receptores de TxC, antes y 1, 3, 6 y 12 meses despues de este. Mediante regresion de Cox se analizo el valor pronostico del valor plasmatico de Gal-3 a los 12 meses del TxC. El objetivo primario del estudio fue la variable combinada muerte o disfuncion del injerto. Resultados Las concentraciones de Gal-3 disminuyeron progresivamente durante el primer ano tras el TxC (medianas: pretrasplante, 19,1 ng/ml; 1 ano postrasplante, 14,6 ng/ml; p Conclusiones Las concentraciones plasmaticas de Gal-3 disminuyeron progresivamente durante el primer ano tras el TxC. Un valor plasmatico elevado de Gal-3 1 ano tras el TxC se correlaciono con un pronostico adverso.
Published: 2019
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12. Galectina-3 circulante tras el trasplante cardiaco: dinámica a largo plazo y valor pronóstico

Author: Paula Blanco-Canosa, José Manuel Vázquez-Rodríguez, Javier Muñiz, Natalia Suárez-Fuentetaja, Gonzalo Barge-Caballero, David Couto-Mallón, María J. Paniagua-Martín, María G. Crespo-Leiro, Francisco Estévez-Cid, Miguel Solla-Buceta, Eduardo Barge-Caballero, Z. Grille-Cancela, José J. Cuenca-Castillo, Nieves Doménech, Jorge Pombo-Otero, Antoni Bayes-Genis, and Lucía Moreda-Santamaría
Subjects: Graft Rejection, Male, Trasplante cardiaco, medicine.medical_specialty, Time Factors, Galectin 3, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Immune system, Risk Factors, Cause of Death, Internal medicine, Galectina-3, Clinical endpoint, Humans, Galectin-3, Medicine, In patient, Retrospective Studies, Cardiovascular mortality, business.industry, Proportional hazards model, Incidence, Pronóstico, General Medicine, Middle Aged, Prognosis, medicine.disease, ROC Curve, Spain, Heart failure, Heart Transplantation, Biomarker (medicine), Female, Heart transplant, business, Biomarkers, Follow-Up Studies
Abstract: [Abstract] Introduction and objectives: Circulating galectin-3 (Gal-3) is elevated and significantly correlates with all-cause and cardiovascular mortality in patients with heart failure. However, the relationship between serum Gal-3 and heart transplant (HT) outcomes is unclear. The aim of this study was to describe the longitudinal trend and prognostic value of Gal-3 levels after HT. Methods: Banked serum samples were available from 122 HT recipients, collected before transplant and at 1, 3, 6, and 12 months posttransplant. Gal-3 levels in these serum samples were measured by enzyme immune assay. Multivariable Cox regression was performed to determine the prognostic value of 12-month posttransplant Gal-3 serum levels. The primary endpoint was the composite variable all-cause death or graft failure over long-term posttransplant follow-up. Results: Circulating Gal-3 concentration steadily decreased during the first year after HT (median values: pretransplant, 19.1 ng/mL; 1-year posttransplant, 14.6 ng/mL; P
Published: 2019
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13. Postoperative Plasma Mitochondrial DNA and Cytokine Profiles of Elderly Patients Undergoing Minimally Invasive Aortic Valve Replacement

Author: Maria E. Serrano-Teruel, José J. Cuenca-Castillo, Victor Bautista-Hernandez, Francisco Estévez-Cid, Alberto Bouzas-Mosquera, Paula Dieguez-Garcia, Fernando Fernandez-Rodriguez, and Mercedes Fernandez-Moreno
Subjects: Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Operative Time, Inflammation, Context (language use), DNA, Mitochondrial, Severity of Illness Index, law.invention, Aortic valve replacement, law, Internal medicine, Severity of illness, Cardiopulmonary bypass, Humans, Medicine, Prospective Studies, Prospective cohort study, Aged, 80 and over, Bioprosthesis, Heart Valve Prosthesis Implantation, business.industry, Age Factors, Aortic Valve Stenosis, medicine.disease, Sternotomy, Sutureless Surgical Procedures, Stenosis, Treatment Outcome, Cytokine, Aortic Valve, Heart Valve Prosthesis, Cardiology, Cytokines, Female, Surgery, Inflammation Mediators, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Cell-Free Nucleic Acids, Biomarkers
Abstract: Introduction Mitochondrial DNA (mtDNA) is gaining increasing interest as a marker of cellular damage and could also act as an inflammatory mediator in cardiopulmonary bypass induced postoperative inflammatory response. Although minimally invasive heart valve surgery reportedly reduces inflammation, the mtDNA and cytokine profile in this context remains unclear.Materials and Methods Here, we report a prospective series of 40 elderly patients with aortic stenosis who underwent bioprosthetic aortic valve replacement (AVR) through upper ministernotomy with either a sutureless (n = 20) or a conventional (n = 20) valve. Primary end points included serial plasma levels of mtDNA (T1: at baseline; T2: 4 hours after surgery; and T3: 24s hour after surgery), cytokines (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α]), and myocardial necrosis biomarkers (MNBs), whereas secondary end points included clinical and echocardiographic data.Results Significant increases in the postoperative plasma levels (T2) of mtDNA, cytokines, and MNBs were observed in all patients. The postoperative plasma levels of mtDNA, TNF-α, and MNBs showed no significant differences between the treatment groups, although there was a trend toward lower levels in the sutureless group. The decreases in aortic cross-clamp and cardiopulmonary bypass times seen in the sutureless group were associated with significant lower postoperative levels (T2 and T3) of IL-6.Conclusion AVR through upper ministernotomy was associated with a significant increase in postoperative plasma levels of mtDNA and cytokines. There was no difference in the mtDNA levels between the sutureless and conventional valve groups, suggesting a similar level of inflammation in both groups. However, the shorter operation time observed in the sutureless valve group was associated with significantly lower postoperative levels of IL-6, indicating potential clinical benefits.
Published: 2019
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14. Recomendaciones de la SECTCV para la cirugía cardiovascular. 2019 actualización de los estándares en organización, actividad profesional, calidad asistencial y formación en la especialidad

Author: Jose M. Garrido, Víctor Bautista Hernández, Jacobo Silva Guisasola, Vivian Legname, Fernando Hornero Sos, Ángel Luis Fernández González, José J. Cuenca Castillo, José López Menéndez, Carlos-A. Mestres Lucio, Belén Adrio Nazar, Rafael Rodríguez Lecoq, Raúl Sánchez Pérez, José Miguel Barquero Aroca, Juan Bustamante Munguira, Tomasa Centella Hernández, Gemma Sánchez Espín, Carlos Martín, Julio García-Puente, Luz Polo López, Miguel Josa García-Tornel, José María Arribas Leal, Gregorio Cuerpo Caballero, María J. Dalmau Sorlí, and José Ignacio Sáez de Ibarra
Subjects: business.industry, lcsh:R, lcsh:Surgery, Medicine, lcsh:Medicine, Surgery, lcsh:RD1-811, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen: La cirugía cardiovascular es la especialidad médica que se ocupa de la prevención, diagnóstico y tratamiento quirúrgico de los trastornos y enfermedades del sistema cardiocirculatorio. Los continuos y rápidos avances en el diagnóstico y tratamiento de las enfermedades cardiovasculares justifican la necesidad de llevar a cabo una actualización de los principales aspectos definitorios y organizativos de la especialidad, relacionados con la profesión (de la práctica, calidad asistencial), con el programa docente de la especialidad, la formación continuada de los cirujanos, los procesos de acreditación desde la Sociedad Española de Cirugía Torácica-Cardiovascular, entre otros.Este documento, elaborado por expertos de la cirugía cardiovascular, representa la opinión de la Sociedad Española de Cirugía Torácica-Cardiovascular y actualiza los principales aspectos de la especialidad en nuestro país. Abstract: Cardiovascular surgery is the medical specialty that deals with the prevention, diagnosis, and surgical treatment of disorders and diseases of the circulatory system. The continuous and rapid advances in the diagnosis and treatment of cardiovascular diseases justify the need to update the main, defining, and organisational aspects of the specialty, related to the profession (its practice, quality care), aspects on the teaching program of the specialty, the continuing education program of the surgeons, the processes of accreditation from the Spanish Society of Thoracic-Cardiovascular Surgery, etc.This document, prepared by experts in cardiovascular surgery, represents the opinion of the Spanish Society of Thoracic-Cardiovascular surgery and updates the main aspects of the specialty in our country. Palabras clave: Cirugía cardiovascular, Cirugía cardíaca, Cirugía torácica, Cirugía vascular, Recomendaciones, Keywords: Cardiovascular surgery, Cardiac surgery, Thoracic surgery, Vascular surgery, Recommendations
Published: 2019

15. Valve-Sparing Tetralogy of Fallot Repair With Intraoperative Dilation of the Pulmonary Valve. Mid-Term Results

Author: Fernando Rueda-Núñez, José J. Cuenca-Castillo, Irene García-Hernández, Maria Garcia-Vieites, Isaac Martinez-Bendayan, Victor Bautista-Hernandez, and María Lozano-Balseiro
Subjects: Balloon Valvuloplasty, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Time Factors, Mid term results, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Pulmonary regurgitation, Humans, Medicine, Cardiac Surgical Procedures, Retrospective Studies, Tetralogy of Fallot, Pulmonary Valve, business.industry, Infant, General Medicine, Left pulmonary artery, medicine.disease, Right pulmonary artery, Pulmonary Valve Insufficiency, Cardiac surgery, Surgery, Pulmonary valve function, Treatment Outcome, medicine.anatomical_structure, 030228 respiratory system, Echocardiography, Pulmonary valve, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Deleterious long-term effects of chronic pulmonary regurgitation after repair of tetralogy of Fallot have become evident during the last decades. Subsequently, some groups have developed strategies to spare the pulmonary valve function at the time of repair with good early results. However, mid-term outcomes are scarce in the literature and in some cases controversial. The aim of our study is to report our results mid-term with valve-sparing repair of tetralogy of Fallot. We retrospectively reviewed patients undergoing tetralogy of Fallot repair and having preservation of the pulmonary valve with intraoperative dilation at our institution. From June 2009 through June 2017, 42 patients underwent valve-sparing tetralogy of Fallot repair. Median age and weight at surgery were 5.2 months and 7.2 kg. Median preoperative pulmonary valve diameters and Z scores by echocardiography were 6.4 mm (range 4.5-11 mm) and -2.3 (range -1.3 to -4.5). No patient died in our series. For a median follow-up of 45 months, the pulmonary valve has grown by Z score (P0.0001) as well as the pulmonary trunk (P= 0.00216). Significant pulmonary regurgitation has developed in 9 patients (21.4%). No patient has required reintervention/reoperation for recurrent right ventricular outflow tract obstruction. Patients with tetralogy of Fallot who had valve-sparing repair with intraoperative dilation of the pulmonary valve show good early and mid-term results with respect to right ventricular outflow tract obstruction. The pulmonary valve annulus and the pulmonary trunk grow through follow-up. Progressive development of significant pulmonary regurgitation is seen in more than 20% of patients. Long-term data with this approach and comparison with a population of patients undergoing a transannular patch repair are required to establish the real utility of this approach.
Published: 2019
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16. Eficacia, seguridad y factores predictores de complicaciones de la extracción de electrodos cardiacos con láser de excímeros

Author: Yago Vilela-González, Carlos Velasco-García, Ignacio Mosquera-Pérez, José J. Cuenca-Castillo, Luisa Pérez-Álvarez, Jorge Rodríguez-Garrido, Víctor Mosquera, and Enrique Ricoy-Martínez
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Resumen Introduccion y objetivos En la ultima decada se ha incrementado la necesidad de extraccion de electrodos transvenosos (EET) de dispositivos electronicos implantables cardiacos (DEIC), frecuentemente en pacientes de alto riesgo. El objetivo del estudio es evaluar las tasas de exito de procedimiento y de exito clinico de la EET con laser de excimeros, asi como la incidencia de complicaciones cardiovasculares, su tratamiento y resultado. Metodos Se analizo a 94 pacientes consecutivos portadores de DEIC tratados mediante EET mediante laser entre junio del 2008 y julio del 2018. Resultados Se extrajeron 170 cables (69 cables auriculares y 101 ventriculares) con una mediana de antiguedad de 81 meses (rango 16-246 meses). Un 69,1% de los pacientes tenian cables de antiguedad > 5 anos y un 36,2% anomalias en la permeabilidad de los ejes venosos. La tasa de exito completo del procedimiento y la tasa de exito clinico fueron del 96,8 y el 97,9%, respectivamente. Se registraron un 6,4% de complicaciones cardiovasculares mayores y un fallecimiento. El analisis bivariante mostro como predictores de complicacion cardiovascular la antiguedad de los cables, los cables bibobina del desfibrilador automatico implantable y la oclusion completa del eje venoso ipsolateral. La mortalidad en pacientes que requirieron intervencion quirurgica o endovascular emergente por complicacion cardiovascular mayor fue del 16,7%. Conclusiones La EET de DEIC mediante laser presenta una notable eficacia y seguridad incluso en pacientes de alto riesgo. Las complicaciones cardiovasculares mayores son infrecuentes, pero potencialmente letales. Su identificacion y tratamiento precoz es fundamental para la supervivencia del paciente.
Published: 2019
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17. Non-contrast transoesophageal echo-guided transapical transcatheter aortic valve replacement: 10-year experience of a renoprotective strategy

Author: José J. Cuenca-Castillo, Alberto Bouzas-Mosquera, José M. Herrera-Noreña, Bárbara Oujo-González, Yago Vilela-González, Carlos Velasco-García, and Víctor Mosquera
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Cardiac Catheterization, medicine.medical_treatment, Renal function, 030204 cardiovascular system & hematology, Prosthesis, Preoperative care, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Valve replacement, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, Stroke, Heart Valve Prosthesis Implantation, Adult Cardiac, business.industry, Acute kidney injury, Odds ratio, Aortic Valve Stenosis, medicine.disease, Treatment Outcome, Aortic Valve, Heart Valve Prosthesis, Cardiology, Surgery, Cardiology and Cardiovascular Medicine, business, Kidney disease
Abstract: OBJECTIVES This study aims to evaluate the efficacy, safety and long-term outcomes of a renoprotective non-contrast, transoesophageal echocardiography-guided transapical (TA) transcatheter aortic valve replacement (TAVR) strategy with a balloon-expandable prosthesis, as well as to determine its impact on renal function. METHODS Between 2009 and 2019, 200 consecutive patients underwent a non-contrast, transoesophageal echocardiography-guided TA TAVR with a balloon-expandable prosthesis. RESULTS The device success rate was 95.5%. Transoesophageal echocardiography-guided deployment demonstrated a low rate of procedure-related complications: 9.5% of acute kidney injury, 8% postoperative bleeding, 6% low-cardiac output, 4.5% postprocedural aortic regurgitation ≥+2, 4% implantation of permanent pacemaker and 2% stroke. There were no significant differences between preoperative and on discharge estimated glomerular filtration rate (53.9 ± 22.2 vs 54.3 ± 22.9 ml/min/1.73 m2, P = 0.60). Logistic regression analysis confirmed postoperative bleeding as an independent predictor for acute kidney injury (odds ratio (OR) 11.148, 95% confidence interval 3.537–35.140, P CONCLUSIONS Non-contrast, transoesophageal echocardiography-guided TA TAVR is a safe and reproducible technique with a low incidence of periprocedural complications that avoids the use of contrast and mitigates the incidence of acute kidney injury.
Published: 2020

18. Prótesis sin sutura: ¿es posible reducir la tasa de bloqueos postoperatorios modificando la técnica de implante?

Author: Víctor X. Mosquera-Rodríguez, Maria Garcia-Vieites, Patricia Pardo-Martinez, José J. Cuenca-Castillo, Laura Fernández-Arias, Carlos Velasco Garcia de Sierra, Miguel González-Barbeito, Francisco Estévez-Cid, Jose María Herrera-Norena, Yago Vilela-González, Carmen Iglesias-Gil, and Jorge Rodriguez-Garrido
Subjects: business.industry, lcsh:R, lcsh:Surgery, lcsh:Medicine, lcsh:RD1-811, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen: Introducción: El recambio valvular aórtico con prótesis sin sutura Perceval S se asocia a un aumento en la tasa de bloqueo auriculoventricular postoperatorio que precisa implante de marcapasos definitivo, comparado con las bioprótesis convencionales. En nuestra serie hemos modificado la técnica de implante (mínimo baloneo
Published: 2018
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19. Mitral Repair as a Treatment of Outflow Tract Obstruction in Hypertrophic Cardiomyopathy: 'Myectomy Without Myectomy'

Author: Jesús Peteiro-Vázquez, Miguel González-Barbeito, Francisco Estévez-Cid, Nicolás Manuel Maneiro-Melón, Roberto Barriales-Villa, and José J. Cuenca-Castillo
Subjects: medicine.medical_specialty, business.industry, Internal medicine, medicine, Hypertrophic cardiomyopathy, Cardiology, Outflow, General Medicine, medicine.disease, business
Published: 2019
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20. Tratamiento de la obstrucción del tracto de salida en la miocardiopatía hipertrófica mediante reparación mitral: «miectomía sin miectomía»

Author: José J. Cuenca-Castillo, Jesús Peteiro-Vázquez, Francisco Estévez-Cid, Nicolás Manuel Maneiro-Melón, Roberto Barriales-Villa, and Miguel González-Barbeito
Subjects: Gynecology, medicine.medical_specialty, business.industry, Medicine, Cardiology and Cardiovascular Medicine, business
Published: 2019
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21. Prognostic Value of the Nutritional Risk Index in Heart Transplant Recipients

Author: Gonzalo Barge-Caballero, David Couto-Mallón, Miguel Solla-Buceta, José Manuel Vázquez-Rodríguez, José J. Cuenca-Castillo, Raquel Marzoa-Rivas, María J. Paniagua-Martín, Carlos Velasco-Sierra, María G. Crespo-Leiro, José M. Herrera-Noreña, Fernando García-López, Francisco Pita-Gutiérrez, and Eduardo Barge-Caballero
Subjects: Male, Trasplante cardiaco, Desnutrición, medicine.medical_specialty, Pediatrics, Ventricular Dysfunction, Right, medicine.medical_treatment, Nutritional Status, Nutritional risk index, Outcomes, 030204 cardiovascular system & hematology, Body weight, Logistic regression, Ventricular Dysfunction, Left, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, Nutritional risk, Retrospective Studies, Heart Failure, Heart transplantation, Proportional hazards model, business.industry, Malnutrition, Pronóstico, Nutritional status, Índice de riesgo nutricional, General Medicine, Length of Stay, Middle Aged, Prognosis, medicine.disease, Malnourishment, Nutrition Assessment, Heart Transplantation, Female, Heart transplant, Primary Graft Dysfunction, business
Abstract: [Abstract] Introduction and objectives. To study the prognostic impact of preoperative nutritional status, as assessed through the nutritional risk index (NRI), on postoperative outcomes after heart transplantation (HT). Methods. We conducted a retrospective, single-center study of 574 patients who underwent HT from 1991 to 2014. Preoperative NRI was calculated as 1.519 × serum albumin (g/L) + 41.7 × (body weight [kg] / ideal body weight [kg]). The association between preoperative NRI and postoperative outcomes was analyzed by means of multivariable logistic regression and multivariable Cox regression. Results. Mean NRI before HT was 100.9 ± 9.9. According to this parameter, the prevalence of severe nutritional risk (NRI < 83.5), moderate nutritional risk (83.5 ≤ NRI < 97.5), and mild nutritional risk (97.5 ≤ NRI < 100) was 5%, 22%, and 10%, respectively. One year post-transplant mortality rates in these 4 categories were 18.2%, 25.3%, 7.9% and 10.2% (P < .001), respectively. The NRI was independently associated with a lower risk of postoperative infection (adjusted OR, 0.97; 95%CI, 0.95-1.00; P = .027) and prolonged postoperative ventilator support (adjusted OR, 0.96; 95%CI, 0.94-0.98; P = .001). Patients at moderate or severe nutritional risk had significantly higher 1-year post-HT mortality (adjusted HR, 1.55; 95%CI, 1.22-1.97; P < .001). Conclusions. Malnourished patients have a higher risk of postoperative complications and mortality after HT. Preoperative NRI determination may help to identify HT candidates who might benefit from nutritional intervention. [Resumen] Introducción y objetivos. Analizar el impacto del estado nutricional preoperatorio, evaluado mediante el índice de riesgo nutricional (IRN), en el pronóstico tras el trasplante cardiaco (TxC). Métodos. Se realizó un estudio retrospectivo de 574 pacientes que recibieron un TxC entre 1991 y 2014 en un centro. El IRN preoperatorio se calculó como 1,519 × albúmina (g/l) + 41,7 × (peso real [kg] / peso ideal [kg]). La asociación entre IRN preoperatorio y eventos clínicos posoperatorios se analizó mediante modelos multivariables de regresión logística y regresión de Cox. Resultados. El IRN preoperatorio medio de la población del estudio era de 100,9 ± 9,9. Según este parámetro, las prevalencias de riesgo nutricional grave (IRN < 83,5), moderado (83,5 ≤ IRN < 97,5) y leve (97,5 ≤ IRN < 100) antes del TxC eran el 5, el 22 y el 10% respectivamente. Las tasas de mortalidad a 1 año tras el TxC en estas 4 categorías fueron del 18,2, el 25,3, el 7,9 y el 10,2% (p < 0,001) respectivamente. El IRN preoperatorio resultó predictor independiente de menor riesgo de infección posoperatoria (odds ratio ajustada [ORa] = 0,97; intervalo de confianza del 95% [IC95%], 0,95-1,00; p = 0,027) y ventilación mecánica prolongada posoperatoria (ORa = 0,96; IC95%, 0,94-0,98; p = 0,001). Los pacientes con riesgo nutricional moderado a grave mostraron mayor mortalidad a 1 año tras el TxC (hazard ratio ajustada = 1,55; IC95%, 1,22-1,97; p < 0,001). Conclusiones. Los pacientes desnutridos tienen mayor riesgo de complicaciones posoperatorias y muerte tras el TxC. La determinación del IRN podría facilitar la identificación de candidatos a TxC que se beneficien de intervenciones nutricionales en espera del órgano.
Published: 2017
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22. Valor pronóstico del índice de riesgo nutricional en receptores de trasplante cardiaco

Author: Gonzalo Barge-Caballero, José Manuel Vázquez-Rodríguez, Raquel Marzoa-Rivas, José M. Herrera-Noreña, David Couto-Mallón, Fernando García-López, Carlos Velasco-Sierra, Eduardo Barge-Caballero, Miguel Solla-Buceta, José J. Cuenca-Castillo, Francisco Pita-Gutiérrez, María J. Paniagua-Martín, and María G. Crespo-Leiro
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen Introduccion y objetivos Analizar el impacto del estado nutricional preoperatorio, evaluado mediante el indice de riesgo nutricional (IRN), en el pronostico tras el trasplante cardiaco (TxC). Metodos Se realizo un estudio retrospectivo de 574 pacientes que recibieron un TxC entre 1991 y 2014 en un centro. El IRN preoperatorio se calculo como 1,519 × albumina (g/l) + 41,7 × (peso real [kg] / peso ideal [kg]). La asociacion entre IRN preoperatorio y eventos clinicos posoperatorios se analizo mediante modelos multivariables de regresion logistica y regresion de Cox. Resultados El IRN preoperatorio medio de la poblacion del estudio era de 100,9 ± 9,9. Segun este parametro, las prevalencias de riesgo nutricional grave (IRN Conclusiones Los pacientes desnutridos tienen mayor riesgo de complicaciones posoperatorias y muerte tras el TxC. La determinacion del IRN podria facilitar la identificacion de candidatos a TxC que se beneficien de intervenciones nutricionales en espera del organo.
Published: 2017
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23. Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

Author: Leticia Seoane-Quiroga, Gonzalo Barge-Caballero, Ángela López-Sainz, José J. Cuenca-Castillo, María J. Paniagua-Martín, María G. Crespo-Leiro, Eduardo Barge-Caballero, José Manuel Vázquez-Rodríguez, José M. Herrera-Noreña, David Couto-Mallón, and Carmen Iglesias-Gil
Subjects: Heart transplantation, Inotrope, medicine.medical_specialty, Ejection fraction, business.industry, medicine.medical_treatment, Incidence (epidemiology), 030204 cardiovascular system & hematology, 030230 surgery, medicine.disease, Confidence interval, Surgery, Transplantation, 03 medical and health sciences, surgical procedures, operative, 0302 clinical medicine, Diabetes mellitus, Heart failure, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: Aim To analyse the incidence, risk factors and clinical outcomes of late graft failure after heart transplantation. Methods and results We conducted an observational, single-centre study based on 547 patients who underwent cardiac transplantation from 1991 to 2014 and who survived the in-hospital postoperative period. Late graft failure was defined as the first hospitalization due to this condition after discharge. Over a mean follow-up of 8.4 ± 6 years, 178 (32.5%) patients were hospitalized due to late graft failure [incidence rate: 3.6 cases per 100 patient-years, 95% confidence interval (CI) 3.1-4.2]. Pre-transplant diabetes, higher pre-transplant transpulmonary pressure gradient and lower donor-recipient weight ratio were independently associated with higher risk of graft failure. Cardiac allograft vasculopathy, cellular rejection grade ≥1R, and antibody-mediated rejection grade ≥1 were detected in 50.6%, 44.9% and 19.2% patients, respectively, admitted due to graft failure. Left ventricular ejection fraction was ≥50% in 60.1% of these patients. Re-transplant free survival 1, 5, 10 and 15 years after the diagnosis of late graft failure was 72.2%, 38.4%, 18.4%, and 7.5%, respectively; the incidence rate of re-hospitalization due to decompensated heart failure was 40.9 episodes per 100 patient-years (95% CI 36.6-46.1). The need for inotropes, the presence of cardiac allograft vasculopathy, higher creatinine serum levels, lower ejection fraction and lower sodium serum levels were independent predictors of worse outcomes. Conclusions Late graft failure is frequent after heart transplantation, as it is associated with poor outcomes. Rejection and cardiac allograft vasculopathy are the most frequent underlying causes.
Published: 2017
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24. Resultados del recambio valvular pulmonar según el tipo de prótesis implantada

Author: Francisco Portela Torrón, Beatriz Bouzas Zubeldía, Isaac Martínez Bendayán, María García Vieites, Daniel Vásquez Echeverri, Laura Fernandez Arias, José J. Cuenca Castillo, and Víctor Bautista Hernández
Subjects: business.industry, lcsh:R, lcsh:Surgery, Recambio valvular pulmonar, lcsh:Medicine, Prótesis biológica, lcsh:RD1-811, 030204 cardiovascular system & hematology, Disfunción protésica, 03 medical and health sciences, Patología tracto de salida ventrículo derecho, 0302 clinical medicine, 030228 respiratory system, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Humanities, Cardiopatías congénitas
Abstract: Resumen Introduccion y objetivos El recambio valvular pulmonar (RVP) es actualmente la intervencion mas frecuente de las cardiopatias congenitas del adulto. Existen numerosas controversias sobre cuando implantar una protesis y; sobre todo, acerca de cual es el sustituto ideal. El objetivo del estudio es revisar el resultado de 3 tipos de protesis biologicas implantadas en nuestro centro. Metodos Desde 2003 se implantaron 3 tipos de protesis biologicas en diferentes momentos: grupo 1-protesis Medtronic Freestyle (n = 14); grupo 2-protesis Sorin Soprano (n = 24), y grupo 3-protesis Carpentier Edwards (n = 15). Se analizaron datos clinicos, ecocardiograficos y de seguimiento, tanto pre como postoperatorios. Resultados El RVP se asocio a una mejoria de la New York Heart Association y a un aumento de la fraccion eyeccion ventriculo izquierdo postoperatoria en nuestra serie. Las caracteristicas preoperatorias fueron similares entre grupos. El grupo 1 presento un gradiente mayor inicial (p = 0,053), aunque estable en el tiempo. El grupo 2 se asocio a una mayor tasa de disfunciones protesicas tardias (p = 0,004). La degeneracion protesica global de la serie fue de 20 pacientes con 5 reintervenciones. No hubo mortalidad precoz y durante el seguimiento fallecieron 4 pacientes, 1 por causa cardiaca. T medio ± desviacion estandar de seguimiento global: 49,98 ± 42,79 meses. Conclusiones El RVP en nuestra serie se ha asociado a una baja tasa de mortalidad perioperatoria. Cuando comparamos segun el tipo de protesis, la protesis Medtronic Freestyle presento un mayor gradiente inicial y en el grupo Sorin Soprano se observa una degeneracion protesica superior a la esperada. Sin embargo, sera necesario mas seguimiento para definir el comportamiento de la protesis Carpentier Edwards.
Published: 2017
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25. Diagnóstico y tratamiento de la obstrucción al flujo en dispositivos de asistencia ventricular de flujo continuo. Un problema infrecuente

Author: María G. Crespo Leiro, David Couto Mallón, Gonzalo Barge Caballero, José J. Cuenca Castillo, Eduardo Barge Caballero, and Jorge Salgado Fernández
Subjects: Gynecology, medicine.medical_specialty, business.industry, medicine, Cardiology and Cardiovascular Medicine, business
Published: 2020
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26. Diagnóstico y tratamiento de la obstrucción al flujo en dispositivos de asistencia ventricular de flujo continuo; un problema infrecuente

Author: Eduardo Barge Caballero, Gonzalo Barge Caballero, José J. Cuenca Castillo, María G. Crespo Leiro, David Couto Mallón, and Jorge Salgado Fernández
Subjects: medicine.medical_specialty, Continuous flow, business.industry, Heart failure, General Medicine, medicine.disease, Flow (mathematics), Internal medicine, medicine, Cardiology, Heart-assist devices, Heart-Assist Devices, business
Abstract: Carta científica
Published: 2020
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27. Abordaje mínimamente invasivo para la asistencia biventricular con bombas centrífugas: primera experiencia en España

Author: Eduardo Barge-Caballero, Miguel González-Barbeito, Francisco Estévez-Cid, Carmen Iglesias-Gil, and José J. Cuenca-Castillo
Subjects: business.industry, Medicine, Cardiology and Cardiovascular Medicine, business, Humanities
Published: 2020
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28. Minimally invasive approach for biventricular assist device with centrifugal pump: first experience in Spain

Author: Miguel González-Barbeito, Eduardo Barge-Caballero, José J. Cuenca-Castillo, Francisco Estévez-Cid, and Carmen Iglesias-Gil
Subjects: medicine.medical_specialty, business.industry, Biventricular assist device, medicine, General Medicine, Centrifugal pump, business, Surgery
Published: 2020
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29. Rapid Deployment Aortic Replacement (RADAR) Registry in Spain: Initial Results

Author: Fernando Hornero, Alejandro Vázquez, Francisco Gutiérrez, Victor Bautista-Hernandez, Sergio Cánovas, Manuel Carnero, Jose M Arribas-Leal, Jose Aurelio Sarralde, José J. Cuenca-Castillo, Natalia Cal-Purriños, Luis Maroto, and Miguel González-Barbeito
Subjects: medicine.medical_specialty, Aortic valve replacement, law, business.industry, Software deployment, Incidence (epidemiology), Emergency medicine, Medicine, Radar, Cardiology and Cardiovascular Medicine, business, medicine.disease, law.invention
Abstract: Objective: The aim of our study is to report our initial results with rapid deployment aortic valve replacement within the Spanish RADAR Registry, especially focusing on the incidence of patient-pr...
Published: 2020
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30. High-Definition Video Recording: Taking Sport Technology to the Operating Room

Author: José J. Cuenca-Castillo, C. Velasco Garcia de Sierra, and Francisco Estévez-Cid
Subjects: Pulmonary and Respiratory Medicine, Operating Rooms, Video Recording, Documentation, 030204 cardiovascular system & hematology, computer.software_genre, Video sharing, 03 medical and health sciences, Upload, 0302 clinical medicine, Task Performance and Analysis, Humans, Medicine, Digital recording, Surgeons, Education, Medical, Multimedia, business.industry, Equipment Design, Surgical procedures, High-definition video, Surgical Procedures, Operative, 030220 oncology & carcinogenesis, High definition, Surgery, The Internet, Line (text file), Cardiology and Cardiovascular Medicine, business, computer
Abstract: Filming surgeries for teaching purposes, publications, and patient records has become increasingly popular as the systems for digital recording have evolved, becoming high-quality systems, both smaller and lighter. Digital recording allows long-term storage, retrieval, and database organization. In addition, sharing digital contents has also become easier since video sharing sites and social networks make it possible to upload these contents onto the Internet. We describe a simple and economical system for surgeons to record surgeries in high definition under sterile conditions without any interference with the surgeon's line of vision.
Published: 2018
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31. Long-Term Outcomes and Durability of the Mitroflow Aortic Bioprosthesis

Author: Javier Muñiz, Carlos Velasco-García, José J. Cuenca-Castillo, José M. Herrera-Noreña, Francisco Portela-Torron, Francisco Estévez-Cid, Víctor Mosquera, and Alberto Bouzas-Mosquera
Subjects: Pulmonary and Respiratory Medicine, Aortic valve, medicine.medical_specialty, business.industry, Incidence (epidemiology), Hemodynamics, Retrospective cohort study, 030204 cardiovascular system & hematology, medicine.disease, Left ventricular hypertrophy, Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030228 respiratory system, Aortic valve replacement, Aortic valve stenosis, medicine, Cumulative incidence, Cardiology and Cardiovascular Medicine, business
Abstract: Background This study aims to determine the incidence and causes of structural valve deterioration (SVD) among all models of Mitroflow bioprostheses (A12/LX/DL), as well as to define their long-term clinical and hemodynamic performance. Methods and Results We retrospectively reviewed a series of 1023 patients who underwent aortic valve replacement with Mitroflow bioprostheses between 2001 and 2014. A small aortic root was found in 22.4% of patients. There were two cases of severe patient-prosthesis mismatch. Only 31 patients developed SVD. The rate of incidence was 8.1 cases per 1000 patient-years. Cumulative incidence of SVD was 1.4% and 3% at five and 10 years, respectively. Freedom from SVD was 97.4% and 88.2% at five and 10 years, respectively. Anticalcification phospholipid reduction treatment (PRT) for model DL was a protective factor for SVD. Multivariable analysis confirmed age 70 years, and cases with severe left ventricular hypertrophy. PRT might contribute to improved long-term durability.
Published: 2016
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32. Paroxysmal bradyarrhythmias are frequent among heart transplant recipients with unexplained syncope: a study based on implantable loop recorders

Author: José Manuel Vázquez-Rodríguez, Ignacio Mosquera-Pérez, David Couto-Mallón, Gonzalo Barge-Caballero, Luisa Pérez-Álvarez, José J. Cuenca-Castillo, Javier Muñiz, Emilse Martínez-Paz, Laura Álvarez-Roy, María J. Paniagua-Martín, María G. Crespo-Leiro, and Eduardo Barge-Caballero
Subjects: medicine.medical_specialty, biology, business.industry, Syncope (genus), 030204 cardiovascular system & hematology, medicine.disease, biology.organism_classification, Loop (topology), 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Heart failure, Cardiology, medicine, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business
Published: 2017
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33. Mitochondrial DNA haplogroups influence the risk of aortic stenosis

Author: Maria Garcia-Vieites, F. Blanco-García, Victor Bautista-Hernandez, Ignacio Rego-Pérez, Nieves Domenech-Garcia, Maria E. Serrano-Teruel, and José J. Cuenca-Castillo
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, DNA, Mitochondrial, Risk Assessment, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Pathological, Genetic Association Studies, Aged, Aged, 80 and over, Heart Valve Prosthesis Implantation, business.industry, Haplotype, General Medicine, Aortic Valve Stenosis, Middle Aged, medicine.disease, Pathophysiology, Stenosis, Phenotype, 030228 respiratory system, Haplotypes, Spain, Aortic valve stenosis, Aortic Valve, Case-Control Studies, Cardiology, Surgery, Female, Cardiology and Cardiovascular Medicine, business, Human mitochondrial DNA haplogroup
Abstract: Aim The underlying pathophysiologic mechanisms of aortic stenosis are not clear. Mitochondrial dysfunction plays a role in many pathological conditions including cardiac diseases. We aimed to analyze the mitochondrial DNA haplogroups in a group of patients undergoing valve replacement surgery due to severe aortic stenosis. Methods Mitochondrial DNA haplogroups were assessed in 176 patients with severe aortic stenosis and 308 control subjects. Cardiovascular risk factors and demographics were similar in both groups. Results Patients carrying haplogroup Uk had a lower risk of developing aortic stenosis, especially compared to patients carrying haplogroup H (odds ratio = 0.507; 95% confidence interval: 0.270–0.952, p = 0.035). Conclusions Mitochondrial DNA haplogroups could be involved in the development of severe aortic stenosis. Specifically, haplogroup H could be a risk factor and Uk a protective factor for severe aortic stenosis in a population from Spain.
Published: 2018

34. Efficacy and safety of transcatheter valve-in-valve replacement for Mitroflow bioprosthetic valve dysfunction

Author: José M. Herrera-Noreña, José J. Cuenca-Castillo, Alberto Bouzas-Mosquera, José Manuel Vázquez-Rodríguez, Víctor Mosquera, Carlos Velasco, Jorge Salgado-Fernández, Nicolás Vázquez-González, Miguel González-Barbeito, and Ramón Calviño-Santos
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, medicine.medical_treatment, Heart Valve Diseases, Hemodynamics, Regurgitation (circulation), 030204 cardiovascular system & hematology, Bioprosthetic valve, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, Bioprosthesis, business.industry, Stent, EuroSCORE, Valve in valve, Prosthesis Failure, Treatment Outcome, 030228 respiratory system, Coronary occlusion, Aortic Valve, Heart Valve Prosthesis, Cardiology, Surgery, Female, Stents, Safety, Cardiology and Cardiovascular Medicine, Complication, business, Follow-Up Studies
Abstract: Objectives Bioprostheses with pericardial leaflets mounted externally on the stent pose a high risk for valve-in-valve (ViV) procedures. This study analyzed the efficacy and safety of ViV procedures for treating structural valve deterioration (SVD) in Mitroflow bioprostheses. Methods Between January 2012 and August 2017, 11 patients (mean age 80.3 ± 5.6 years) were treated for SVD of Mitroflow bioprostheses with transcatheter ViV procedures (six transapical [TA] and five transfemoral [TF]) using balloon expandable bioprostheses. Results All patients but one were in NYHA class III-IV. Mean STS PROM, euroSCORE I, and euroSCORE II were 8 ± 6.5%, 27.8 ± 11.5%, and 12 ± 5.9%, respectively. Two patients had a "porcelain aorta." The size of implanted valves were 23 mm in 10 cases and 26 mm in one case. One patient suffered a coronary occlusion during a TF approach. The mean volume of contrast used in TF implants was 163 ± 69.8 mL. No contrast media were used in TA procedures. There was one in-hospital death (10%). At 1 year of follow-up, peak and mean aortic gradients were 25.5 ± 5.8 mmHg and 15.5 ± 5.7 mmHg, respectively. One patient had mild paravalvular regurgitation. Cumulative survival was 90.9% at 1 year, 70.7% at 2 years, and 53% at 3 years. Conclusions ViV procedures with balloon-expandable aortic valves provide good hemodynamic and clinical mid-term results for treating patients with a degenerated Mitroflow aortic bioprosthesis. Special care must be taken in small aortic roots, when the stented valve is in the supra-annular position to avoid coronary ostial obstruction.
Published: 2018

35. Transaxillary Implantation of the Impella CP Mechanical Circulatory Support Device as a Bridge to Heart Transplant. First Experience in Spain

Author: Francisco Estévez-Cid, Carlos García-Velasco, María G. Crespo-Leiro, Miguel Solla-Buceta, José J. Cuenca-Castillo, and David Couto-Mallón
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Forensic engineering, Medicine, General Medicine, 030204 cardiovascular system & hematology, business, Bridge (interpersonal), Impella
Published: 2019
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36. Quality markers in cardiology: measures of outcomes and clinical practice —a perspective of the Spanish Society of Cardiology and of Thoracic and Cardiovascular Surgery1

Author: Fausto J. Pinto, José Ramón López Mínguez, Regina Dalmau, José-Luis López-Sendón, José Luis Pomar Moya-Prats, Alessandro Sionis, Domingo A. Pascual-Figal, José Luis Zamorano, Alicia M. Maceira, Lina Badimon, José J. Cuenca Castillo, Esteban González Torrecilla, and José Ramón González-Juanatey
Subjects: medicine.medical_specialty, business.industry, media_common.quotation_subject, Perspective (graphical), lcsh:R, lcsh:Surgery, lcsh:Medicine, lcsh:RD1-811, Clinical Practice, Internal medicine, Cardiology, Medicine, Surgery, Quality (business), Cardiology and Cardiovascular Medicine, business, media_common
Published: 2015
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37. Comentarios al documento INCARDIO: Indicadores de Calidad en Unidades Asistenciales del Área del Corazón

Author: Tomasa Centella Hernández, Fernando Hornero Sos, and José J. Cuenca Castillo
Subjects: business.industry, lcsh:R, lcsh:Surgery, lcsh:Medicine, Medicine, Surgery, lcsh:RD1-811, Cardiology and Cardiovascular Medicine, business, Humanities
Published: 2015
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38. Significado pronóstico y evolución a largo plazo de la frecuencia cardiaca en los pacientes con trasplante cardiaco

Author: María J. Paniagua-Martín, Gonzalo Barge-Caballero, María G. Crespo-Leiro, Alfonso Castro-Beiras, Eduardo Barge-Caballero, José J. Cuenca-Castillo, Jesús Jiménez-López, S. Chávez-Leal, Raquel Marzoa Rivas, and Z. Grille-Cancela
Subjects: business.industry, Medicine, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen Introduccion y objetivos Estudiar la evolucion y el significado pronostico de la frecuencia cardiaca tras el trasplante cardiaco. Metodos Estudio observacional de 170 pacientes que recibieron un trasplante cardiaco bicavo entre 1995 y 2005; todos estaban en ritmo sinusal. La frecuencia cardiaca en reposo se determino a partir de electrocardiogramas al final del primer ano tras el trasplante y anualmente hasta el decimo ano. Mediante analisis de Cox, se evaluo la incidencia de eventos adversos en un seguimiento medio de 8,9 ± 3,1 anos. El evento principal del estudio fue la variable combinada muerte o disfuncion del injerto. Resultados La frecuencia cardiaca en reposo, medida al final del primer ano tras el trasplante, fue un predictor independiente del evento combinado principal (hazard ratio = 1,054; intervalo de confianza del 95%, 1,028-1,080; p Conclusiones La frecuencia cardiaca elevada es un marcador pronostico adverso tras el trasplante cardiaco.
Published: 2015
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39. Implante transaxilar del dispositivo de asistencia circulatoria Impella CP como puente al trasplante cardiaco: primera experiencia en España

Author: María G. Crespo-Leiro, David Couto-Mallón, Carlos García-Velasco, Francisco Estévez-Cid, Miguel Solla-Buceta, and José J. Cuenca-Castillo
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, 0206 medical engineering, Medicine, 02 engineering and technology, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, 020601 biomedical engineering, Humanities
Abstract: Carta científica
Published: 2017

40. Evolution of conservative treatment of acute traumatic aortic injuries: lights and shadows

Author: José M. Herrera-Noreña, Miguel González-Barbeito, Daniel Gulias-Soidan, José J. Cuenca-Castillo, Carlos E. Velasco, Víctor Mosquera, Milagros Marini, and Daniel Fraga-Manteiga
Subjects: Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Aortography, 030204 cardiovascular system & hematology, Conservative Treatment, Wounds, Nonpenetrating, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Injury Severity Score, medicine.artery, medicine, Humans, Stage (cooking), Aorta, Retrospective Studies, medicine.diagnostic_test, Proportional hazards model, business.industry, Disease Management, Retrospective cohort study, General Medicine, Odds ratio, Middle Aged, Vascular System Injuries, Surgery, Survival Rate, Treatment Outcome, Spain, Cohort, Acute Disease, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Objectives The objective of this study is to compare early and long-term results in terms of survival and aortic complications for traumatic aortic injuries depending on the initial management strategy. Methods From January 1980 to January 2017, 101 patients with aortic injuries were divided into 3 groups according to management strategy at admission: 60 patients, conservative management; 26 patients, open surgery and 15 patients, endovascular repair. The groups were similar in terms of gender and trauma severity scores. Results All but 1 aortic-related complications and aortic-related mortality occurred in the conservative group (11.6% conservative vs 2.4% in both surgical and endovascular groups, P = 0.091). Total follow-up was 1109.27 patient-years. Survival in the conservative, surgical and endovascular group was 71.7%, 80.8% and 79.4% at 1 year, 68.2%, 80.8% and 79.4% at 5 years and 63.9%, 72.7% and 79.4% at 10 years, respectively (log-rank = 0.218). The rate of aortic-related complications was 58.3% in the conservative cohort. Cox regression identified the following risk factors for aortic-related complications: aortic injuries grade >I [odds ratio (OR), 3.05; P = 0.021], Trauma Injury Severity Score >50% (OR 1.21; P = 0.042) and the decade of treatment (OR 0.49; P = 0.011). Conclusions Minimal aortic injuries seem to be an amenable target for medical management, but patients remain at risk of developing aortic-related complications. Close, long-term imaging surveillance is mandatory to detect such complications at an early stage.
Published: 2017

41. Paroxysmal bradyarrhythmias are frequent among heart transplant recipients with unexplained syncope: a study based on implantable loop recorders

Author: Emilse, Martínez-Paz, Eduardo, Barge-Caballero, Laura, Álvarez-Roy, Gonzalo, Barge-Caballero, David, Couto-Mallón, María J, Paniagua-Martín, Ignacio, Mosquera-Pérez, Luisa, Pérez-Álvarez, Javier, Muñiz, José J, Cuenca-Castillo, José Manuel, Vázquez-Rodríguez, and María G, Crespo-Leiro
Subjects: Heart Failure, Male, Spain, Incidence, Bradycardia, Electrocardiography, Ambulatory, Heart Transplantation, Humans, Female, Middle Aged, Transplant Recipients
Published: 2017

42. Perceval Less Invasive Aortic Replacement Register: multicentric Spanish experience with the Perceval S bioprosthesis in moderate-high-risk aortic surgery

Author: Gregorio Cuerpo Caballero, Elisabet Berastegui García, Ángel González Pinto, Fabrizio Sbraga, Eladio Sanchez Dominguez, Julio Garcia Puente, Remedios Rios Barrera, Maria Luisa Camara Rosell, Ivan García Martin, Francisco Estevez Cid, Guillermo Reyes Copa, Santiago Serrano Fiz, José J. Cuenca Castillo, Xavier Ruyra Baliarda, José A. Buendía Miñano, Marian Tena Pajuelo, Sergio Cánovas López, Juan Bustamante Munguira, and Elena Rosello Diez
Subjects: Pulmonary and Respiratory Medicine, Aortic valve, medicine.medical_specialty, medicine.medical_treatment, Periprosthetic, 030204 cardiovascular system & hematology, Prosthesis Design, Prosthesis, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Aortic valve replacement, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Registries, Prospective cohort study, Survival rate, Aged, Bioprosthesis, business.industry, Incidence, EuroSCORE, Aortic Valve Stenosis, medicine.disease, Surgery, Survival Rate, medicine.anatomical_structure, Echocardiography, Spain, Aortic valve stenosis, Aortic Valve, Heart Valve Prosthesis, Female, Cardiology and Cardiovascular Medicine, business
Abstract: OBJECTIVES: The development of new percutaneous and surgical techniques has reduced the risk associated with aortic valve replacement procedures. We present the results of a Spanish register after initiating a programme for sutureless prostheses in moderatehigh-risk patients. METHODS: This prospective multicentre study was carried out from November 2013 to November 2016. Data were obtained from 448 patients in whom a Perceval S prosthesis was implanted. RESULTS: The mean age was 79.24 (standard deviation [SD] 4.1) years, and 61.2% were women. The estimated EuroSCORE I log risk was 11.15% (SD 7.6), with an observed mortality of 4.4% (20 patients). Isolated aortic valve replacement was performed on 69.26% of patients, with 64% involving ministernotomy. The incidence of neurological events was 2%, with 2 permanent cerebrovascular accidents, and 41 (9.2%) patients were implanted with a permanent endocavitary pacemaker. At discharge, 12 (2.6%) patients presented minimal periprosthetic leakage, and 4 (0.89%) patients had moderate leakage. There were 3 reinterventions during follow-up (2 endocarditis and 1 dysfunction due to periprosthetic leak progression). The mean gradient at discharge, 6 months and 1 year was 12.94 (SD 5.3) mmHg, 12.19 (SD 4.7) mmHg and 11.77 (SD 4.7) mmHg, respectively; 59.4% of the patients were octogenarians, with a survival rate of 98% at both 6 months and 1 year at discharge. There was neither valve migration nor early structural degeneration. The mean follow-up was 12 ± 3 months. The 6-month and 1-year mortality was 1.4% and 2.1%, respectively. CONCLUSIONS: This is a prospective multicentric study on the largest cohort of patients with sutureless valves conducted in Spain to date. It is a reproducible procedure that has enabled surgery on patients with a moderatehigh risk with low morbidity and mortality, providing good haemodynamic results.
Published: 2017

43. Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

Author: Ángela, López-Sainz, Eduardo, Barge-Caballero, Gonzalo, Barge-Caballero, David, Couto-Mallón, María J, Paniagua-Martin, Leticia, Seoane-Quiroga, Carmen, Iglesias-Gil, José M, Herrera-Noreña, José J, Cuenca-Castillo, José M, Vázquez-Rodríguez, and María G, Crespo-Leiro
Subjects: Graft Rejection, Heart Failure, Male, Time Factors, Incidence, Middle Aged, Prognosis, Risk Assessment, Survival Rate, Risk Factors, Spain, Heart Transplantation, Humans, Female, Follow-Up Studies, Retrospective Studies
Abstract: To analyse the incidence, risk factors and clinical outcomes of late graft failure after heart transplantation.We conducted an observational, single-centre study based on 547 patients who underwent cardiac transplantation from 1991 to 2014 and who survived the in-hospital postoperative period. Late graft failure was defined as the first hospitalization due to this condition after discharge. Over a mean follow-up of 8.4 ± 6 years, 178 (32.5%) patients were hospitalized due to late graft failure [incidence rate: 3.6 cases per 100 patient-years, 95% confidence interval (CI) 3.1-4.2]. Pre-transplant diabetes, higher pre-transplant transpulmonary pressure gradient and lower donor-recipient weight ratio were independently associated with higher risk of graft failure. Cardiac allograft vasculopathy, cellular rejection grade ≥1R, and antibody-mediated rejection grade ≥1 were detected in 50.6%, 44.9% and 19.2% patients, respectively, admitted due to graft failure. Left ventricular ejection fraction was ≥50% in 60.1% of these patients. Re-transplant free survival 1, 5, 10 and 15 years after the diagnosis of late graft failure was 72.2%, 38.4%, 18.4%, and 7.5%, respectively; the incidence rate of re-hospitalization due to decompensated heart failure was 40.9 episodes per 100 patient-years (95% CI 36.6-46.1). The need for inotropes, the presence of cardiac allograft vasculopathy, higher creatinine serum levels, lower ejection fraction and lower sodium serum levels were independent predictors of worse outcomes.Late graft failure is frequent after heart transplantation, as it is associated with poor outcomes. Rejection and cardiac allograft vasculopathy are the most frequent underlying causes.
Published: 2017

44. Rationale and design of a multicentre, prospective, randomised, controlled clinical trial to evaluate the efficacy of the adipose graft transposition procedure in patients with a myocardial scar: the AGTP II trial

Author: Pablo Avanzas, J. Alberto San Román, Ramon Brugada, Eduardo de Teresa, Jacobo Silva, Domingo A. Pascual-Figal, Pablo García-Pavia, Julio Núñez, María G. Crespo-Leiro, Josep Lupón, Ana Revilla-Orodea, Maria Luisa Camara, Francisco Fernández-Avilés, Ángel González-Pinto, José J. Cuenca-Castillo, Ángel Caballero, Nicolás Manito, Juan Bustamante-Munguira, Carolina Gálvez-Montón, Sergio Cánovas, Albert Teis, Antoni Bayes-Genis, José M. Melero, Paloma Gastelurrutia, and Carlos Martín
Subjects: 0301 basic medicine, Cardiac function curve, Adult, Male, medicine.medical_specialty, Cardiac Volume, Myocardial Infarction, Adipose tissue, 030204 cardiovascular system & hematology, Cardiovascular Medicine, Transplantation, Autologous, Ventricular Function, Left, 03 medical and health sciences, Cicatrix, 0302 clinical medicine, pericardial adipose graft, Natriuretic Peptide, Brain, Clinical endpoint, Protocol, Medicine, Humans, Regeneration, Myocardial infarction, Prospective Studies, Coronary Artery Bypass, adipose progenitor cells, Randomized Controlled Trials as Topic, clinical trials, Ejection fraction, business.industry, Myocardium, cardiac regeneration, General Medicine, Brain natriuretic peptide, Institutional review board, medicine.disease, Peptide Fragments, Surgery, Clinical trial, 030104 developmental biology, Treatment Outcome, Adipose Tissue, Research Design, tissue engineering, chronic myocardial infarction, Female, business
Abstract: IntroductionCardiac adipose tissue is a source of progenitor cells with regenerative capacity. Studies in rodents demonstrated that the intramyocardial delivery of cells derived from this tissue improves cardiac function after myocardial infarction (MI). We developed a new reparative approach for damaged myocardium that integrates the regenerative properties of cardiac adipose tissue with tissue engineering. In the adipose graft transposition procedure (AGTP), we dissect a vascularised flap of autologous pericardial adipose tissue and position it over the myocardial scarred area. Following encouraging results in acute and chronic MI porcine models, we performed the clinical trial (NCT01473433, AdiFLAP trial) to evaluate safety in patients with chronic MI undergoing coronary artery bypass graft. The good safety profile and trends in efficacy warranted a larger trial.Study designThe AGTP II trial (NCT02798276) is an investigator initiated, prospective, randomised, controlled, multicentre study to assess the efficacy of the AGTP in 108 patients with non-revascularisable MI. Patients will be assigned to standard clinical practice or the AGTP. The primary endpoint is change in necrotic mass ratio by gadolinium enhancement at 91 and 365 days. Secondary endpoints include improvement in regional contractibility by MRI at 91 and 365 days; changes in functional MRI parameters (left ventricular ejection fraction, left and right ventricular geometric remodelling) at 91 and 365 days; levels of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) at 7, 91 and 365 days; appearance of arrhythmias from 24 hour Holter monitoring at 24 hours, and at 91 and 365 days; all cause death or re-hospitalisation at 365 days; and cardiovascular death or re-hospitalisation at 365 days.Ethics and disseminationThe institutional review board approved the trial which will comply with the Declaration of Helsinki. All patients will provide informed consent. It may offer a novel, effective and technically simple technique for patients with no other therapeutic options. The results will be submitted to indexed medical journals and national and international meetings.Trial registration numberClinicalTrials.gov:NCT02798276, pre-results.
Published: 2017

45. Indexed left atrial size predicts all-cause and cardiovascular mortality in patients undergoing aortic valve surgery

Author: Victor Bautista-Hernandez, Javier Muñiz, Alberto Bouzas-Mosquera, Víctor Mosquera, Nemesio Álvarez-García, José J. Cuenca-Castillo, and Miguel González-Barbeito
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Time Factors, Aortic Valve Insufficiency, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Aortic valve diseases, Left atrial, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Left atrial enlargement, Humans, In patient, 030212 general & internal medicine, Heart Atria, Cardiac Surgical Procedures, Aortic valve surgery, Stroke, Cardiovascular mortality, Aged, Retrospective Studies, Outcome, Aged, 80 and over, business.industry, Indexed left atrial diameter, Aortic Valve Stenosis, Atrial Remodeling, Middle Aged, medicine.disease, Confidence interval, Surgery, Treatment Outcome, Echocardiography, Aortic Valve, Cardiology, Atrial Function, Left, Female, Cardiology and Cardiovascular Medicine, business, All cause mortality
Abstract: [Abstract] OBJECTIVES: The enlargement of the left atrium has been identified as a marker of chronically increased left ventricular filling pressure and left ventricular diastolic dysfunction. This study aims to evaluate the association of indexed left atrial diameter with stroke, cardiovascular mortality, the combined event, and all-cause mortality in patients who underwent aortic valve surgery. METHODS: Indexed left atrial diameter was measured in 2011 adult patients (mean age, 70.9 ± 10.8 years; 58.7% were men) who underwent aortic valve surgery between January 2008 and March 2016. RESULTS: On the basis of the criteria of the American Society of Echocardiography, indexed left atrial diameter was normal in 64% of patients, mildly enlarged in 12.4% of patients, moderately enlarged in 9.2% of patients, and severely enlarged in 14.3% of patients. Over a mean follow-up period of 3.2 ± 2.1 years, there were 334 deaths and 97 strokes. Cardiovascular mortality survival at 5 years among patients with normal, mild, moderate, and severe left atrial enlargement was 91.6%, 86.8%, 77.9%, and 77.4%, respectively (P < .001). After covariable adjustment, Cox regression analysis showed indexed left atrial diameter as an independent predictor of all-cause mortality (hazard ratio per 1-cm/m2 increment, 1.545; 95% confidence interval, 1.252-1.906, P < .001), cardiovascular death (hazard ratio per 1-cm/m2 increment, 1.971; 95% confidence interval, 1.541-2.520; P < .001), and the combined event (hazard ratio per 1-cm/m2 increment, 1.673; 95% confidence interval, 1.321-2.119; P < .001). CONCLUSIONS: Indexed left atrial diameter is a strong predictor of long-term outcomes in patients with aortic valve diseases who undergo surgery.
Published: 2017

46. Impacto del tratamiento anticalcificación en la durabilidad de la bioprótesis Mitroflow y factores de riesgo para el deterioro valvular estructural

Author: Laura Fernández-Arias, Concepción Pradas-Irún, Jose María Herrera-Norena, Victor Bautista-Hernandez, Carlos Velasco-García, Carmen Iglesias-Gil, Francisco Portela-Torrón, Miguel González-Barbeito, Víctor Mosquera, José J. Cuenca-Castillo, Maria Garcia-Vieites, Francisco Estévez-Cid, Alberto Bouzas-Mosquera, and Daniel Vasquez-Echeverri
Subjects: Gynecology, medicine.medical_specialty, Deterioro valvular estructural, business.industry, Calcificación, lcsh:R, Bioprótesis, lcsh:Surgery, lcsh:Medicine, lcsh:RD1-811, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Sustitución valvular aórtica, Medicine, Surgery, Ecocardiografía, Cardiology and Cardiovascular Medicine, business
Abstract: Objetivo: Determinar la incidencia de deterioro valvular estructural (DVE) entre todos los modelos de bioprótesis aórtica Mitroflow (A12/LX/DL), así como definir los factores de riesgo implicados y el posible papel protector del tratamiento anticalcificación phospholipid reduction treatment (PRT) del modelo DL. Métodos: Estudio retrospectivo de 1.023 pacientes consecutivos operados de recambio valvular aórtico con bioprótesis Mitroflow entre 2001 y 2014. Resultados: El seguimiento medio fue de 5,4 ± 3,1 años. La incidencia acumulada global de DVE fue 0,48% a un año, 2,1% a 5 años y 6,8% a 10 años. El grupo PRT mostró menor incidencia acumulada de DVE (0,2% vs. 1,2% a 4 años) (p = 0,04). El análisis de regresión de riesgos competitivos confirmó: edad < 70 años (HR = 2,98 [1,5-5,89], p = 0,002), tamaño valvular de 19 mm (HR = 4,7 [2,29-9,64], p 30 mmHg en postoperatorio precoz (HR = 10,3 [5,3-19,9], p
Published: 2017
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47. Post-introduction observation of transcatheter aortic valve implantation in Galicia (Spain)

Author: Marisa López-García, Teresa Queiro-Verdes, José Ramón González-Juanatey, Ramiro Trillo Nouche, José Antonio Baz-Alonso, Nicolás Vázquez-González, Leonor Varela-Lema, Gonzalo Pradas-Montilla, Andrés Íñiguez-Romo, Diego López-Otero, José Rubio-Álvarez, Darío Durán-Muñoz, José J. Cuenca-Castillo, José M. Herrera Noreña, and Jorge Salgado-Fernández
Subjects: medicine.medical_specialty, Percutaneous aortic valve replacement, business.industry, Health Policy, medicine.medical_treatment, Public Health, Environmental and Occupational Health, Health services research, Psychological intervention, Context (language use), medicine.disease, Prosthesis, Surgery, Aortic valve stenosis, Health care, Emergency medicine, medicine, Observational study, business
Abstract: Rationale, aims and objectives Transcatheter aortic valve implantation constitutes an example of a technology introduced into the Galician Health Care System basket and subjected to a post-introduction observational study after coverage. This paper aims to describe the process and results of this experience, illustrating the main challenges and opportunities in using these studies for supporting decision making. Methods The study protocol was developed by a multidisciplinary team consisting of experts from the Galician HTA Agency (avalia-t), interventional cardiologists and cardiac surgeons. Together they agreed on the information that was relevant and feasible for collection, and planned the study design, data collection and analysis of results. Results During the 1-year recruitment period, 94 patients underwent percutaneous aortic valve replacement in the three authorized centres. Implantation rate and prosthesis models differed substantially across the centres. Overall, procedural success rate was 96.8% and hospital mortality was 7.4%. Complications during post-surgical admission were recorded in 40.4% of patients. Moderate residual aortic regurgitation was observed in 10% of patients, and the procedure was associated with a stroke rate of 3.3% at 30 days and 5.3% at 1 year. Conclusions Post-introduction observation has made it feasible to determine the use of this procedure within the SERGAS context and has enabled the assessment of performance in real-life conditions. The proposed strategic actions and interventions have been drawn up based upon the collective judgement of a group of experienced professionals, and have served to establish recommendations on further research that would be required to optimize health benefits.
Published: 2014
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48. Evolución y distribución de la formación MIR en cirugía cardiovascular en España. Implicaciones en la relación oferta-demanda en nuestra especialidad

Author: José J. Cuenca Castillo
Subjects: business.industry, lcsh:R, lcsh:Surgery, Medicine, lcsh:Medicine, Surgery, lcsh:RD1-811, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Desde muchas Sociedades Cientificas y Comisiones Nacionales e especialidad, hemos contemplado con sorpresa las convocatoias MIR de cada ano. En diversas especialidades, pero sobre todo en a nuestra, Cirugia Cardiovascular (CCV), el numero de plazas MIR fertadas han, cuanto menos, duplicado sistematicamente las recoendaciones de nuestra Comision Nacional. Se pueden argumentar iferentes razones para justificarlo, pero parece evidente que, como n otras especialidades, la obligada necesidad de adecuar la oferta e plazas para formacion especializada, a la de estudiantes de Mediina que acaban sus estudios cada ano en nuestras universidades, s el factor clave. Hasta hace unos 5 anos, encontrar un especialista en CCV en aro, en nuestro pais, era francamente complicado, tan solo, casos xcepcionales e incluso temporales. El progresivo recambio generaional fue absorbiendo el inicial incremento de plazas de formacion. n estos ultimos anos, la ralentizacion en las jubilaciones por la rolongacion de la edad laboral o su mantenimiento en 70 anos, en lgunas CC. AA., la amortizacion de algunas plazas y las dificultaes economicas en el sector sanitario publico, han provocado una norme precariedad del mercado laboral para CCV, contratos de uardias, acumulos de tareas temporales y, sobre todo, necesidad e realizar nuevas especialidades dentro del programa MIR, o marhar a continuar su formacion en centros de fuera de Espana. En una ublicacion reciente (8 de septiembre del 2014) de Diario Medico, citando una encuesta telefonica realizada a los MIR finalizados ntre 2009 y 2012, auspiciada por la Subdireccion General de Ordeacion Profesional del Ministerio de Sanidad, se refleja que nuestra specialidad, con un 23% de paro entre ellos, es la especialidad uirurgica con mas paro y la segunda global, tras la Microbiologia.
Published: 2015
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49. Comments on the ESC Guidelines on the Management of Valvular Heart Disease (Version 2012). A Report of the Task Force of the Clinical Practice Guidelines Committee of the Spanish Society of Cardiology

Author: Javier Lopez, Josep Comín, Manuel Pan, Isidre Vilacosta, Rafael García Fuster, José Eduardo López Haldón, Pilar Tornos, Antonio Fernández-Ortiz, Ángel M. Alonso Gómez, Alberto San Román, Miguel Angel García Fernández, Isabel Diaz-Buschmann, José Luis Zamorano, Arturo Evangelista, Manuel Anguita, Marta Sitges, José Ignacio Sáez de Ibarra, Rosana Hernández Antolín, Patricia Mahía, Javier Bermejo, Joaquín Barba, Ángel Luis Fernández González, Juan José Gómez Doblas, José María Hernández García, Xavier Borrás, Rocío García Orta, Gonzalo Barón, José Juan Gómez de Diego, Fernando Wornerm, Ignacio Fernández Lozano, Angel Cequier, and José J. Cuenca Castillo
Subjects: medicine.medical_specialty, business.industry, Task force, valvular heart disease, Heart Valve Diseases, MEDLINE, General Medicine, medicine.disease, Clinical Practice, Spain, Internal medicine, Practice Guidelines as Topic, Physical therapy, Cardiology, Humans, Medicine, Cardiac Surgical Procedures, business
Published: 2013
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50. Long-Term Outcomes and Durability of the Mitroflow Aortic Bioprosthesis

Author: Victor X, Mosquera, Alberto, Bouzas-Mosquera, Carlos, Velasco-García, Javier, Muñiz, Francisco, Estévez-Cid, Francisco, Portela-Torron, José M, Herrera-Noreña, and José J, Cuenca-Castillo
Subjects: Bioprosthesis, Male, Time Factors, Hemodynamics, Aortic Valve Stenosis, Prosthesis Design, Postoperative Complications, Echocardiography, Spain, Aortic Valve, Heart Valve Prosthesis, Materials Testing, Humans, Female, Aged, Follow-Up Studies, Retrospective Studies
Abstract: This study aims to determine the incidence and causes of structural valve deterioration (SVD) among all models of Mitroflow bioprostheses (A12/LX/DL), as well as to define their long-term clinical and hemodynamic performance.We retrospectively reviewed a series of 1023 patients who underwent aortic valve replacement with Mitroflow bioprostheses between 2001 and 2014. A small aortic root was found in 22.4% of patients. There were two cases of severe patient-prosthesis mismatch. Only 31 patients developed SVD. The rate of incidence was 8.1 cases per 1000 patient-years. Cumulative incidence of SVD was 1.4% and 3% at five and 10 years, respectively. Freedom from SVD was 97.4% and 88.2% at five and 10 years, respectively. Anticalcification phospholipid reduction treatment (PRT) for model DL was a protective factor for SVD. Multivariable analysis confirmed age70 years and use of 19 mm valve as independent predictors of SVD. Cumulative survival was 76.6% at five years and 42.3% at 10 years (mean follow-up 3.8 ± 3.1 years). In multivariable analysis, neither the use of small aortic prosthesis (p = 0.18) nor the occurrence of SVD (p = 0.85) was found to be independent predictors of long-term survival.Mitroflow valves demonstrate an acceptable rate of SVD and satisfactory long-term hemodynamic performance, particularly in patients with small aortic roots, age70 years, and cases with severe left ventricular hypertrophy. PRT might contribute to improved long-term durability. doi: 10.1111/jocs.12726 (J Card Surg 2016;31:264-273).
Published: 2016

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