1. Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms
- Author
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Elisabet Berthold, Reza Rasti, Maria Altman, Charlotta Nordenhäll, Petter Brodin, Michele Compagno, Fatine Khammari Nystrom, Jenny Lingman Framme, Selma Idring Nordström, Erik Sundberg, Anders Fasth, Eva Säve-Söderbergh, Antti Kukka, Karin Palmblad, André Rudolph, Petra Król, Fredrik Bäckström, Robin Kahn, Karin Rydenman, Lillemor Berntson, Stefan Berg, Maria Mossberg, Bengt Månsson, Josefin Hättting, and AnnaCarin Horne
- Subjects
medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Abnormal echocardiogram ,Adolescent ,Critical Care ,persistent symptoms ,outcomes ,Pediatrics ,World health ,Internal medicine ,Intensive care ,medicine ,Humans ,Medical history ,Child ,abnormal echocardiograms ,intensive care ,Aged ,business.industry ,SARS-CoV-2 ,Pediatrik ,COVID-19 ,General Medicine ,Systemic Inflammatory Response Syndrome ,Population based study ,Echocardiography ,Pediatrics, Perinatology and Child Health ,fatigue ,Abnormal results ,business - Abstract
Aim: Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. Methods: This national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow-up protocols are suggested. Results: We identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS-C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results. Conclusion: More than a third (36%) of the patients had persistent symptoms 8 weeks after MIS-C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow-up visits are important after MIS-C.
- Published
- 2021