1. Manniindole, an indole derivative from the roots of Anonidium mannii and combined antischistosomal and enzymatic activities
- Author
-
Josette Linda Toussi Matchi, Marc Nothisen, Jean Claude Tchouankeu, Jérôme Boissier, Sylvain Ursuegui, Guilhem Chaubet, Silvère Ngouela, Delphine Garnier, Diderot T. Noungoue, Isabelle Kuhn, Alain Wagner, Conception et application de molécules bioactives (CAMB), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Yaoundé I, Interactions Hôtes-Pathogènes-Environnements (IHPE), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Perpignan Via Domitia (UPVD), University of Yaounde I, Dept Chim Inorgan, Lab Physicochim Mat Min, Yaounde, Cameroon, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Stereochemistry ,Annonaceae ,Plant Science ,[CHIM.THER]Chemical Sciences/Medicinal Chemistry ,indole alkaloid ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,Anonidium mannii ,phytochemical and biological investigation ,parasitic diseases ,Cytotoxicity ,ComputingMilieux_MISCELLANEOUS ,Indole test ,chemistry.chemical_classification ,Indole alkaloid ,biology ,010405 organic chemistry ,Chemistry ,enzymatic activity (SmNACE) ,Alkaloid ,[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] ,Organic Chemistry ,antischistosomal activity ,[SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics ,biology.organism_classification ,anti-schistosomal activity ,3. Good health ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Enzyme ,cytotoxicity ,Derivative (chemistry) - Abstract
International audience; A new alkaloid, manniindole 1, together with four known compounds: aristolactam AII 2, aristolactam BII 3, piperolactam D 4 and polycarpol 5 were isolated from the crude extract EtOHH2O (8:2) of the roots of Anonidium mannii by chromatographic separation. The structure elucidation was performed on the basis of a spectroscopic analysis (IR, HRESI MS, 1D and 2D NMR) as well as a comparison of their spectral data with those reported in the literature. For the first time, the crude extract and those isolated compounds were evaluated for their antischistosomal activity against Schistosoma mansoni and for cytotoxicity activity against Huh7 and A549 cells. Furthermore, they were also tested in vitro on the recent characterized Schistosoma mansoni NADþ catabolizing enzyme (SmNACE) for their impact on this enzyme which is localized on the outer surface of the adult parasite. Compound 2 displayed quite good worm killing capability, while 4 showed significant inhibition of SmNACE
- Published
- 2021
- Full Text
- View/download PDF