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This study was carried out to determine the correlation between patients with wounds and isolated Pseudomonas aeruginosa and Staphylococcus aureus in clinics at Barau Dikko Teaching Hospital, Kaduna, Nigeria. The Socio-demographic, medical and drug histories and characteristics of the wounds from each consented patient were taken using a questionnaire along with sixty samples of the patient’s wound swab samples. Isolation of Pseudomonas aeruginosa and Staphylococcus aureus from the wound swab samples was carried out using standard phenotypic and genotypic procedures. Out of the 60 samples collected, 30 (50.0%) each were from general out-patient and inpatients. The higher percentage 12 (20.0%) and 39 (65.0%) were patients in the age group between 61 and above and male patients respectively. Regarding the patient’s occupations, the higher percentage 20 (33.3%) of the patients were businessmen and women. The patient’s wound location indicated that a higher percentage of 38 (63.3%) wounds were located on the leg. Also, only 13 (21.7%) patients had diabetes and 44 (73.3%) of the wound patients were receiving antimicrobials; the commonest being metronidazole 11 (18.33%), followed by mupirocin/Supirocin 9 (15.6%). A total of eleven isolates each of Pseudomonas aeruginosa and Staphylococcus aureus were isolated from the sixty wound swab samples of the in-and out-patients. Association between antimicrobial agents use and the organisms showed significant difference (P < 0.05), while the association between sex, diabetes status, duration of the wound and the isolation of Pseudomonas aeruginosa and Staphylococcus aureus from the wound of patients showed no statistically significant difference (P > 0.05).

Infections caused by micro-organisms affect the health of people and animals, causing morbidity and mortality, with Asia and Africa as the epicenters. Some of the infectious diseases are emerging and re-emerging in nature. Examples include viral hepatitis, Lassa fever, Ebola, yellow fever, tuberculosis, covid-19, measles, and malaria, among others. Antimicrobials have been playing an important role in the treatment of infections by these microbes. However, there has been a development of resistance to these antimicrobials as a result of many drivers. This write-up used secondary data to explore the management of antimicrobial resistance (AMR) beyond the hospital antimicrobial resistance steward using the one health concept. The findings showed AMR to be a transboundary, multifaceted ecosystem problem affecting both the developed and developing countries. It is also one of the top ten global public health threats facing mankind. Globally, AMR will cost over US$100 trillion in output loss by 2050, about 700,000 deaths a year, and 4,150,000 deaths in Africa by 2050. About 2.4 million people could die in high-income countries between 2015 and 2050 without a sustained effort to contain AMR. The drivers of AMR are beyond the hospital and hospital AMR stewardship. Therefore, the need for one health concept to manage it.

Antimicrobial resistance (AMR) is a threat to global health security and may reverse the gains in preventive medicine. This is worsened by the fact that development of resistance out-paces that of new antimicrobials. The factors driving the development of AMR range from health systems to socio-economic and environmental factors. These include poor antimicrobial stewardship, poor access to quality drugs, prescribing antimicrobials without susceptibility laboratory tests, use of antimicrobials in crop, animal production and aquaculture farming. Others are lack of coordinated medical and veterinary health systems strengthening, poor universal health coverage and practice of one health. The burden of the problem is of public health importance especially in Africa where there is high incidence of poverty, high incidence of out-of-pocket health expenditure, lack of basic social amenities and weak health systems with poor collaboration. The impact of AMR includes increased burden on the healthcare system, hospital admission, cost of patient treatment, poor clinical outcomes and impact on food security, among others. In view of the interplay of various systems and factors in the development and emergence of AMR, there is need for multi-sectoral and interdisciplinary approach at global, regional, national and local levels for its prevention and mitigation. Strengthening of health systems from the medical and veterinary perspectives and universal health coverage are critical in the fight against AMR. The relevant stakeholders include political leaders, community leaders, health professionals, academics, and research institutions, federal and state ministries of health, agriculture, education and Nongovernmental organisations among others. Conflict of interest: None declared, South Eastern European Journal of Public Health (SEEJPH), Special Volume No. 2, 2021: Announcing the Hideyo Noguchi Africa Prize (1st edition)

Infections caused by micro-organisms affect the health of people and animals, causing morbidity and mortality, with Asia and Africa as the epicenters. Some of the infectious diseases are emerging and re-emerging in nature. Examples include viral hepatitis, Lassa fever, Ebola, yellow fever, tuberculosis, covid-19, measles, and malaria, among others. Antimicrobials have been playing an important role in the treatment of infections by these microbes. However, there has been a development of resistance to these antimicrobials as a result of many drivers. This write-up used secondary data to explore the management of antimicrobial resistance (AMR) beyond the hospital antimicrobial resistance steward using the one health concept. The findings showed AMR to be a transboundary, multifaceted ecosystem problem affecting both the developed and developing countries. It is also one of the top ten global public health threats facing mankind. Globally, AMR will cost over US$100 trillion in output loss by 2050, about 700,000 deaths a year, and 4,150,000 deaths in Africa by 2050. About 2.4 million people could die in high-income countries between 2015 and 2050 without a sustained effort to contain AMR. The drivers of AMR are beyond the hospital and hospital AMR stewardship. Therefore, the need for one health concept to manage it.

Background: Nigeria and Rwanda are both developing countries located in Sub-Saharan Africa. They are differently endowed with natural and human resources but what does that translates into in terms of health care?This study aimed at a critical comparative analysis of selected health indicators of Nigeria and Rwanda(a country ravaged by genocide 16 years ago). Materials and Methods: I performed MEDLINE and bibliographic searches for English-language studies relevant to health indicators of Nigeria and Rwanda, including a search of non-indexed local journals. Personal observation and experience as Nigerian Technical Aid Corp Volunteer in Rwanda from May 2005 to May 2007 was also used. The information obtained included: demographic and socioeconomic data, mortality statistics, selected burden of diseases, health service coverage, risk factors for some diseases, health system resources and health expenditure of Nigeria and Rwanda. Results: The findings showed that most of the health indicators such as poverty index, life expectancy, child mortalities, immunisation coverage, contraceptive prevalence, access to improved drinking water, tuberculosis treatment success, hospital beds per population, among others of Rwanda are better than that of Nigeria despite the huge human and natural resources Nigeria is endowed with. Conclusion: There is need for concerted effort at the Federal, State and Local levels in Nigeria to harness the human and natural resources of the nations to improve on the health status of the people, and this should bemulti-sectoral, multi-dimensional and disciplinary in nature.

Injection safety practice is an important component of basic infection control but in low income settings like the prisons where the seroprevalence of blood borne infections are significantly higher. These remains neglected under the pressure of overwhelming social, economic and political challenges and put the patients and healthcare providers at risk of infectious and non-infectious adverse events. This study assessed the level of knowledge and practice of injection safety among health care workers of Nigerian prison service health facilities in Kaduna State, Command. A cross sectional descriptive study using multistage sampling technique was employed by means of structured interviewer administered questionnaire to 138 prison health workers carried out in January 2012. Data analysis was by use of Statistical Package for Social Sciences (SPSS version 17), with statistical significance set at p-value of 0.05. The findings showed that 54.3% of Health workers had good knowledge score of key injection safety issues, while 16.7% and 29.0% had had fair and poor general knowledge scores respectively. About half (50.4%) had fair practice of injection safety. There was statistical significance between knowledge and practice of injection safety in relation to cadre of staff (p value 0.000), staff that had training on injection safety (p value 0.003) and years of experience of the staff (p value 0.032) respectively. There was good knowledge score and fair practice of injection safety among health workers. The determinant factors were the cadre, training and years of experience of the workers. Therefore, it was concluded that regular and on the job training programs on core aspect of injection safety among health workers should be conducted by the health departments of Nigerian prison service on regular basis.

Typhoid fever treatment failure due to emergence of antibiotics resistant Salmonella enterica serovar Typhi has become a matter of concern to public health sector. This study was aimed at investigating the in vitro antimicrobial activity of stem bark extracts of Azadirachta indica A. (JUSS) against antibiotic resistant Salmonella enterica serovar Typhi isolates from stool samples of patients manifesting clinical features of typhoid fever. Fortyseven (47) isolates were identified as Salmonella sp. using conventional biochemical test, Microbact TM 12A/12E Gram-negative kits, and confirmed molecularly using ompC primers. Twelve (12) isolates out of the 47 were Salmonella enterica serovar Typhi identified serologically and confirmed molecularly using STY4220 primers. Antibiotics resistance profile of the Salmonella enterica serovar Typhi isolates showed that 12 (100%) were resistance to amoxicillin and amoxicillin/clavulanic acid, 9 (75%) resistance to tetracycline, cotrimoxazole and cefotaxime, 6 (50%) resistance to ceftriaxone, 3 (25%) resistance to nitrofurantoin, 2 (17%) resistance to chloramphenicol, 1 (8%) resistance to ofloxacin and ciprofloxacin; while 12 (100%) were sensitive to nalidixic acid and imipenem. Qualitative phytochemical and spectroscopic analysis of Azadirachta indica stem bark extracts revealed the presence of tannins, alkaloids, flavonoids, glycosides, saponins, phenolic and other organic compounds. At concentrations of 25-400 mg/ml, potency test of acetone and ethanolic bark extracts of the plant against the Salmonella enterica serovar Typhi isolates produced diameter zones of growth inhibition ranges from 18-35 mm and 15-31 mm respectively. The minimum inhibitory concentrations values of the extracts against the isolates also ranged from 50-100 mg/ml. It may be concluded from this results that the bark extracts of Azadirachta indica A. (JUSS) have good growth inhibitory effects against the antibiotics resistant Salmonella enterica serovar Typhi and can be developed further for chemotherapeutic application.

There is a general recognition of homosexuality being responsible for the high prevalence of HIV/AIDS among inmates in Nigerian prisons. However, the use of condoms which is an evidenced-based preventive measure is critical in the prison setting because of socio-cultural reasons. Due to the dynamic nature of the prison population, interventions targeting the prisons will have a significant effect on the general population. This study assessed condom acceptability for the prevention of HIV infection among male inmates in a convict prison in north-western, Nigeria in order to provide supplementary information that will corroborate some findings from quantitative methods. A qualitative study was conducted in Zaria prison between 18th December, 2012 and 8th January, 2013. Purposive sampling identified 48 inmates who had Focused Group Discussions (FGDs) and In‐depth Interviews (IDIs). Common trends and variations in the responses were identified and reflected as appropriate and presented as narratives with relevant quotations. Majority of the respondents agreed that homosexuality exists among the inmates, but all the inmates scowled at the distribution of condoms to inmates in prison. Majority were of the opinion that condom distribution will promote homosexuality which is prohibited by Nigerian laws and controlling HIV transmissions in Nigeria prisons can be effectively done through behavioral modifications that are geared towards total abstinence.