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Your search keyword '"Joyce Reyes-Thomas"' showing total 3 results
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3 results on '"Joyce Reyes-Thomas"'

1. Contributors

Author

Joseph M. Ahearn, Marta E. Alarcón-Riquelme, Salem J. Almaani, Jennifer H. Anolik, Cynthia Aranow, Maria A. Bacalao, Maria-Louise Barilla-LaBarca, Jennifer L. Barnas, Guillermo Barturen, Bonnie L. Bermas, Sasha Bernatsky, I.N. Bruce, Richard Bucala, Jill P. Buyon, Elena Carnero-Montoro, Ann E. Clarke, Megan E.B. Clowse, Josef Symon S. Concha, Paul Dellaripa, Betty Diamond, Tracy J. Doyle, Michelle M.A. Fernando, John D. Fisk, Richard Furie, Caroline Gordon, Teri M. Greiling, Shuhong Han, John G. Hanly, Grace A. Hile, Diane Horowitz, David Isenberg, Peter Izmirly, Barbara Jacobs, Judith A. James, J. Michelle Kahlenberg, Kenneth C. Kalunian, Insoo Kang, Mariana J. Kaplan, Munther A. Khamashta, Mimi Kim, Jason S. Knight, Fotios Koumpouras, Martin A. Kriegel, Antonio La Cava, Alexandra Ladouceur, Robert G. Lahita, Iris Jung-Won Lee, Christopher J. Lessard, Laura B. Lewandowski, Yun Liang, Chau-Ching Liu, Meggan Mackay, Michael P. Madaio, Galina Marder, Eric L. Matteson, Sara McCoy, Maureen McMahon, Eric Meffre, Juan Mejia-Vilet, Joan Merrill, Eric F. Morand, Sara Moreira Pinto, Shuichiro Nakabo, Melissa Northcott, Antonina Omisade, Thomas L. Ortel, Andras Perl, Rosalind Ramsey-Goldman, Westley H. Reeves, Joyce Reyes-Thomas, J.A. Reynolds, Bruce Richardson, Juan Vicente Rodriguez, Brad H. Rovin, Alla Rudinskaya, Guillermo Ruiz-Irastorza, Amit Saxena, Laura E. Schanberg, Tarun S. Sharma, Brian Skaggs, Emily C. Somers, William Stohl, Mehret Birru Talabi, Kandice L. Tessneer, Betty P. Tsao, Amaia Ugarte, Bruce T. Volpe, Timothy J. Vyse, Benjamin J. Wainwright, Michael M. Ward, Mary Chester M. Wasko, Victoria P. Werth, Leanna Wise, Haoyang Zhuang, and Yu Zuo

Published
2021
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3. Measurement of cell-bound complement activation products enhances diagnostic performance in systemic lupus erythematosus

Author

Rosalind Ramsey-Goldman, Rachel L. Gross, Kyriakos A. Kirou, Christine Hsieh, Cole Harris, Kenneth C. Kalunian, Jill P. Buyon, Puja Chitkara, Arthur Weinstein, Chaim Putterman, Thierry Dervieux, Richard Furie, Joyce Reyes-Thomas, Emily C. Somers, W. Winn Chatham, and Elena Massarotti

Subjects
Adult, Blood Platelets, Male, Erythrocytes, Anti-nuclear antibody, Complement receptor 1, Immunology, Sensitivity and Specificity, Serology, Rheumatology, immune system diseases, Complement C4b, medicine, Humans, Lupus Erythematosus, Systemic, Vimentin, Immunology and Allergy, Pharmacology (medical), skin and connective tissue diseases, Complement Activation, Aged, Aged, 80 and over, B-Lymphocytes, Lupus erythematosus, biology, business.industry, Case-control study, Area under the curve, DNA, Middle Aged, medicine.disease, Peptide Fragments, Antibodies, Anti-Idiotypic, Receptors, Complement, Complement system, Cross-Sectional Studies, Antibodies, Antinuclear, Case-Control Studies, Multivariate Analysis, biology.protein, Female, biology.gene, Antibody, business, Biomarkers
Abstract

To determine the value of cell-bound complement activation products in combination with antinuclear antibody (ANA), anti-double-stranded DNA antibody (anti-dsDNA), and anti-mutated citrullinated vimentin antibody (anti-MCV) for the diagnosis of systemic lupus erythematosus (SLE).This was a multicenter cross-sectional study in which 593 subjects were enrolled (210 SLE patients, 178 patients with other rheumatic diseases, and 205 healthy subjects). Complement receptor 1 levels on erythrocytes (ECR1) together with complement C4d levels on erythrocytes (EC4d), platelets (PC4d), and B cells (BC4d) were determined using fluorescence-activated cell sorting. Serologic markers were measured by enzyme-linked immunosorbent assay. Statistical analyses were performed using area under the curve (AUC), logistic regression, and calculations of diagnostic sensitivity and specificity.Anti-dsDNA was an insensitive (30%) but specific (95%) marker for SLE. Levels of EC4d, BC4d, and PC4d were several times higher, and levels of ECR1 lower, in SLE patients compared to patients with other rheumatic diseases and healthy subjects. Among 523 anti-dsDNA-negative subjects, multivariate logistic regression analysis revealed that SLE was associated with ANA positivity (≥20 units), anti-MCV negativity (≤70 units), and elevated levels of both EC4d and BC4d (AUC 0.918, P0.001). A positive index score corresponding to the weighted sum of these 4 markers correctly categorized 72% of SLE patients. Specificity in relation to patients with other rheumatic diseases and healthy controls was90%. The combination of anti-dsDNA and index score positivity yielded 80% sensitivity for SLE and 87% specificity against other rheumatic diseases.An assay panel combining anti-dsDNA, ANA, anti-MCV, EC4d, and BC4d is sensitive and specific for the diagnosis of SLE.

Published
2012
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