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7. Circulating Tumor Cells in Esophageal Squamous Cell Carcinoma – Mini Review

Author

Shi,Yujing, Ge,Xiaolin, Ju,Mengyang, Zhang,Yumeng, Di,Xiaoke, and Liang,Liang

Subjects
Cancer Management and Research
Abstract

Yujing Shi,1 Xiaolin Ge,2 Mengyang Ju,3 Yumeng Zhang,4 Xiaoke Di,2 Liang Liang1 1Jurong People’s Hospital, Zhenjiang, 212400, People’s Republic of China; 2Jiangsu Provincial People’s Hospital, Nanjing, 212000, People’s Republic of China; 3Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, 5650871, Japan; 4Nanjing Medical University, Nanjing, 212000, People’s Republic of ChinaCorrespondence: Liang LiangJurong People’s Hospital, Huayang Town, Jurong City, People’s Republic of ChinaTel +86 511-8730 0705Email lianglvlv@yeah.netAbstract: Esophageal cancer has high incidence and mortality rates and a low five-year survival rate of < 15% owing to its strong capabilities of invasion, relapse and metastasis. The classic view holds that metastasis and diffusion is an advanced event during cancer progression, but recent studies show that distant diffusion of primary cancer cells may actually be an early event. Detection of circulating tumor cells (CTCs) in the circulation may indicate tumor spread, so CTCs are considered to be the key factor of metastatic cascade. In recent years, despite research progress on CTCs, there is a lack of systematic and important evidence to confirm the diagnostic, monitoring and prognostic values of CTCs in esophageal squamous cell carcinoma (ESCC). In this review, we clarify the relationship between CTC values and ESCC and provide more reliable evidence to improve the management and treatment of ESCC.Keywords: esophageal squamous cell carcinoma, circulating tumor cells, diagnostic, prognostic

Published
2021

10. Synergistic Effects of Melatonin on Radiosensitization in Carbon-ion Radiotherapy.

Author

Ju M, Minami K, Katsuki S, Takenaka W, Tatekawa S, Tamari K, Koizumi M, Takahashi Y, and Ogawa K

Subjects
Cell Line, Tumor, Mice, Animals, Humans, Cell Survival drug effects, Cell Survival radiation effects, Melanoma, Experimental radiotherapy, Melanoma, Experimental drug therapy, Melanoma, Experimental pathology, DNA Breaks, Double-Stranded drug effects, DNA Breaks, Double-Stranded radiation effects, Melatonin pharmacology, Heavy Ion Radiotherapy, Radiation Tolerance drug effects, DNA Repair drug effects, DNA Repair radiation effects, Radiation-Sensitizing Agents pharmacology
Abstract

Background/aim: Despite the established antitumor effectiveness and synergistic interactions of melatonin with photon irradiation, its role in carbon-ion radiotherapy remains uncertain. This study aimed to elucidate the mechanisms and potential clinical advantages of combining exogenous melatonin therapy with carbon-ion radiotherapy., Materials and Methods: The investigation assessed the impact of combining exogenous melatonin with photon or carbon-ion irradiation on cell-cycle modulation and DNA-repair capability using the melanoma cell line B16F10. RNA sequencing and bioinformatics analysis were conducted to explore mechanisms and evaluate potential clinical benefits, with validation performed on the osteosarcoma cell line LM8., Results: Pre-treatment with melatonin reduced the survival fraction of B16F10 and LM8 cells upon exposure to photon and carbon-ion radiation. Mechanistically, melatonin was found to inhibit G 2 /M arrest, preserve DNA damage, and suppress key genes involved in DNA double-strand break repair after 8 Gy carbon-ion radiation. Furthermore, RNA sequencing and bioinformatics analysis revealed favorable changes in genes associated with survival and metastasis, highlighting potential clinical significance. LM8 cells treated with melatonin exhibited increased radiosensitivity and suppression of DNA-repair proteins., Conclusion: The combination of exogenous melatonin not only heightened radiosensitivity and modulated hallmark tumor gene sets in vitro but also markedly suppressed the efficiency of DNA double-strand break-repair pathway, thus enhancing the cytotoxicity of carbon-ion radiotherapy., (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2024
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