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Your search keyword '"Juárez-Velázquez, María del Rocío"' showing total 7 results
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7 results on '"Juárez-Velázquez, María del Rocío"'

2. Pure Interstitial Trisomy 11q Arising from a Nonrecurrent 11q13.1q22.3 Mosaic Intrachromosomal Duplication in a Patient with Craniofacial Dysmorphism and Genital Anomalies

Author

Martínez Anaya, Daniel, primary, Juárez-Velázquez, María del Rocío, additional, Reyes Ruvalcaba, Sinuhé, additional, Navarrete-Meneses, María del Pilar, additional, Salas Labadía, Consuelo, additional, Lieberman Hernández, Esther, additional, and Pérez-Vera, Patricia, additional

Published
2023
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3. CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways

Author

Moreno Lorenzana, Dafné, Juárez Velázquez, María del Rocío, Reyes León, Adriana, Martínez Anaya, Daniel, Hernández Monterde, Adrián, Salas Labadía, Consuelo, Navarrete Meneses, María del Pilar, Zapata Tarrés, Marta, Juárez Villegas, Luis, Jarquín Ramírez, Berenice, Cárdenas Cardós, Rocío, Herrera Almanza, Martha, Paredes Aguilera, Rogelio, and Pérez Vera, Patricia

Subjects
CRLF2, Fusion Proteins, bcr-abl, acute lymphoblastic leukemia, Ikaros Transcription Factor, primary rearrangements, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, hemic and lymphatic diseases, Pathology, Humans, Protein Isoforms, RB1-214, Receptors, Cytokine, Child, Mexico, Mexican children, Gene Rearrangement, TCF3‐PBX1 concurrent with P2RY8‐CRLF2, Original Articles, Precursor Cell Lymphoblastic Leukemia-Lymphoma, IKZF1, Child, Preschool, Original Article, Gene Fusion, Biomarkers, activated signaling pathways, Signal Transduction
Abstract

The gene fusions BCR‐ABL1, TCF3‐PBX1, and ETV6‐RUNX1 are recurrent in B‐cell acute lymphoblastic leukemia (B‐ALL) and are found with low frequency in coexistence with CRLF2 (cytokine receptor‐like factor 2) rearrangements and overexpression. There is limited information regarding the CRLF2 abnormalities and dominant‐negative IKZF1 isoforms associated with surrogate markers of Jak2, ABL, and Ras signaling pathways. To assess this, we evaluated 24 Mexican children with B‐ALL positive for recurrent gene fusions at diagnosis. We found CRLF2 rearrangements and/or overexpression, dominant‐negative IKZF1 isoforms, and surrogate phosphorylated markers of signaling pathways coexisting with recurrent gene fusions. All the BCR‐ABL1 patients expressed CRLF2 and were positive for pCrkl (ABL); most of them were also positive for pStat5 (Jak2/Stat5) and negative for pErk (Ras). TCF3‐PBX1 patients with CRLF2 abnormalities were positive for pStat5, most of them were also positive for pCrkl, and two patients were also positive for pErk. One patient with ETV6‐RUNX1 and intracellular CRLF2 protein expressed pCrkl. In some cases, the activated signaling pathways were reverted in vitro by specific inhibitors. We further analyzed a TCF3‐PBX1 patient at relapse, identifying a clone with the recurrent gene fusion, P2RY8‐CRLF2, rearrangement, and phosphorylation of the three surrogate markers that we studied. These results agree with the previous reports regarding resistance to treatment observed in patients with recurrent gene fusions and coexisting CRLF2 gene abnormalities. A marker phosphorylation signature was identified in BCR‐ABL1 and TCF3‐PBX1 patients. To obtain useful information for the assessment of treatment in B‐ALL patients with recurrent gene fusions, we suggest that they should be evaluated at diagnosis for CRLF2 gene abnormalities and dominant‐negative IKZF1 isoforms, in addition to the analyses of activation and inhibition of signaling pathways.

Published
2021

4. Characterization of Philadelphia-like Pre-B Acute Lymphoblastic Leukemia: Experiences in Mexican Pediatric Patients

Author

Martínez-Anaya, Daniel, primary, Moreno-Lorenzana, Dafné, additional, Reyes-León, Adriana, additional, Juárez-Figueroa, Ulises, additional, Dean, Michael, additional, Aguilar-Hernández, María Montserrat, additional, Rivera-Sánchez, Netzi, additional, García-Islas, Jessica, additional, Vieyra-Fuentes, Victoria, additional, Zapata-Tarrés, Marta, additional, Juárez-Villegas, Luis, additional, Paredes-Aguilera, Rogelio, additional, Vega-Vega, Lourdes, additional, Rivera-Luna, Roberto, additional, Juárez-Velázquez, María del Rocío, additional, and Pérez-Vera, Patricia, additional

Published
2022
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5. High occurrence of CRLF2 abnormalities in Mexican children with B-cell acute lymphoblastic leukemia

Author

Juárez-Velázquez, María del Rocío, primary, Moreno-Lorenzana, Dafné Linda, additional, Martínez Anaya, Daniel Alejandro, additional, Hernández Monterde, Eduardo Adrián, additional, Aguilar-Hernández, María Montserrat, additional, Reyes-León, Adriana, additional, Chávez-González, María Antonieta, additional, López Santiago, Norma, additional, Zapata Tarrés, Marta, additional, Juárez Villegas, Luis, additional, Rivera Sánchez, Netzi, additional, Soto Lerma, Oscar, additional, Vega-Vega, Lourdes, additional, Rivera Luna, Roberto, additional, and Pérez-Vera, Patricia, additional

Published
2022
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6. CRLF2andIKZF1abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways

Author

Moreno Lorenzana, Dafné, primary, Juárez Velázquez, María del Rocío, additional, Reyes León, Adriana, additional, Martínez Anaya, Daniel, additional, Hernández Monterde, Adrián, additional, Salas Labadía, Consuelo, additional, Navarrete Meneses, María del Pilar, additional, Zapata Tarrés, Marta, additional, Juárez Villegas, Luis, additional, Jarquín Ramírez, Berenice, additional, Cárdenas Cardós, Rocío, additional, Herrera Almanza, Martha, additional, Paredes Aguilera, Rogelio, additional, and Pérez Vera, Patricia, additional

Published
2021
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7. High Frequency of the Ph-like PCB-ALL Subtype in Mexican Pediatric Patients. Experience in Two Institutions

Author

Perez-Vera, Patricia, primary, Moreno Lorenzana, Dafne, additional, Juárez-Velázquez, María Del Rocío, additional, Martínez-Anaya, Daniel Alejandro, additional, Reyes-León, Adriana, additional, Hernández-Monterde, Adrián, additional, Aguilar, Maria Montserrat, additional, Soto Lerma, Oscar, additional, Herrera-Almanza, Martha, additional, Zapata-Tarres, Marta, additional, Juarez-Villegas, Luis, additional, Cardenas-Cardos, Rocio, additional, Rivera-Luna, Roberto, additional, and Olaya-Vargas, Alberto, additional

Published
2018
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