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10 results on '"Juan-Mateu, Jonas"'

1. Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

Author

Sarkar, Soumyadeep, Deiter, Cailin, Kyle, Jennifer E., Guney, Michelle A., Sarbaugh, Dylan, Yin, Ruichuan, Li, Xiangtang, Cui, Yi, Ramos-Rodriguez, Mireia, Nicora, Carrie D., Syed, Farooq, Juan-Mateu, Jonas, Muralidharan, Charanya, Pasquali, Lorenzo, Evans-Molina, Carmella, Eizirik, Decio L., Webb-Robertson, Bobbie-Jo M., Burnum-Johnson, Kristin, Orr, Galya, Laskin, Julia, Metz, Thomas O., Mirmira, Raghavendra G., Sussel, Lori, Ansong, Charles, and Nakayasu, Ernesto S.

Published
2024
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2. Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

Author

Sarkar, Soumyadeep, primary, Deiter, Cailin, additional, Kyle, Jennifer E., additional, Guney, Michelle A., additional, Sarbaugh, Dylan, additional, Yin, Ruichuan, additional, Li, Xiangtang, additional, Cui, Yi, additional, Ramos-Rodriguez, Mireia, additional, Nicora, Carrie D., additional, Syed, Farooq, additional, Juan-Mateu, Jonas, additional, Muralidharan, Charanya, additional, Pasquali, Lorenzo, additional, Evans-Molina, Carmella, additional, Eizirik, Decio L., additional, Webb-Robertson, Bobbie-Jo M., additional, Burnum-Johnson, Kristin, additional, Orr, Galya, additional, Laskin, Julia, additional, Metz, Thomas O., additional, Mirmira, Raghavendra G., additional, Sussel, Lori, additional, Ansong, Charles, additional, and Nakayasu, Ernesto, additional

Published
2023
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5. The role of islet lipid composition remodeling in regulation of beta-cell death via ADP-ribosyl-acceptor glycohydrolase ARH3 signaling in insulitis

Author

Nakayasu, Ernesto S., primary, Deiter, Cailin, additional, Kyle, Jennifer E., additional, Guney, Michelle A., additional, Sarbaugh, Dylan, additional, Yin, Ruichuan, additional, Cui, Yi, additional, Nicora, Carrie D., additional, Syed, Farooq, additional, Juan-Mateu, Jonas, additional, Mirmira, Raghavendra G., additional, Evans-Molina, Carmella, additional, Eizirik, Decio L., additional, Webb-Robertson, Bobbie-Jo M., additional, Burnum-Johnson, Kristin, additional, Orr, Galya, additional, Laskin, Julia, additional, Metz, Thomas O., additional, Sussel, Lori, additional, and Ansong, Charles, additional

Published
2020
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7. MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Author

Grieco, Fabio Arturo, primary, Sebastiani, Guido, additional, Juan-Mateu, Jonas, additional, Villate, Olatz, additional, Marroqui, Laura, additional, Ladrière, Laurence, additional, Tugay, Ksenya, additional, Regazzi, Romano, additional, Bugliani, Marco, additional, Marchetti, Piero, additional, Dotta, Francesco, additional, and Eizirik, Décio L., additional

Published
2016
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10. MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.

Author

Grieco, Fabio Arturo, Sebastiani, Guido, Juan-Mateu, Jonas, Villate, Olatz, Marroqui, Laura, Ladrière, Laurence, Tugay, Ksenya, Regazzi, Romano, Bugliani, Marco, Marchetti, Piero, Dotta, Francesco, and Eizirik, Décio L.

Subjects
TYPE 1 diabetes, MICRORNA, PANCREATIC beta cells, BCL-2 proteins, APOPTOSIS, INTERLEUKIN-1, INTERFERON gamma, GENETIC regulation, PHYSIOLOGY, PROTEIN metabolism, RNA metabolism, CELLS, FLUORESCENT antibody technique, GENES, ISLANDS of Langerhans, PROTEINS, RESEARCH funding, RNA, WESTERN immunoblotting
Abstract

Type 1 diabetes (T1D) is an autoimmune disease leading to β-cell destruction. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression and organ formation. They participate in the pathogenesis of several autoimmune diseases, but the nature of miRNAs contributing to β-cell death in T1D and their target genes remain to be clarified. We performed an miRNA expression profile on human islet preparations exposed to the cytokines IL-1β plus IFN-γ. Confirmation of miRNA and target gene modification in human β-cells was performed by real-time quantitative PCR. Single-stranded miRNAs inhibitors were used to block selected endogenous miRNAs. Cell death was measured by Hoechst/propidium iodide staining and activation of caspase-3. Fifty-seven miRNAs were detected as modulated by cytokines. Three of them, namely miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent human β-cell apoptosis. These results identify a novel cross talk between a key family of miRNAs and proapoptotic Bcl-2 proteins in human pancreatic β-cells, broadening our understanding of cytokine-induced β-cell apoptosis in early T1D. [ABSTRACT FROM AUTHOR]

Published
2017
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