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9. The Contributions of Breast Density and Common Genetic Variation to Breast Cancer Risk

Author

Vachon, Celine M, Pankratz, V Shane, Scott, Christopher G, Haeberle, Lothar, Ziv, Elad, Jensen, Matthew R, Brandt, Kathleen R, Whaley, Dana H, Olson, Janet E, Heusinger, Katharina, Hack, Carolin C, Jud, Sebastian M, Beckmann, Matthias W, Schulz-Wendtland, Ruediger, Tice, Jeffrey A, Norman, Aaron D, Cunningham, Julie M, Purrington, Kristen S, Easton, Douglas F, Sellers, Thomas A, Kerlikowske, Karla, Fasching, Peter A, and Couch, Fergus J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Prevention, Cancer, Clinical Research, Women's Health, 4.1 Discovery and preclinical testing of markers and technologies, Adult, Aged, Area Under Curve, Breast, Breast Density, Breast Neoplasms, Case-Control Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Germany, Humans, Logistic Models, Mammary Glands, Human, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Radiography, Risk Assessment, Risk Factors, United States, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

We evaluated whether a 76-locus polygenic risk score (PRS) and Breast Imaging Reporting and Data System (BI-RADS) breast density were independent risk factors within three studies (1643 case patients, 2397 control patients) using logistic regression models. We incorporated the PRS odds ratio (OR) into the Breast Cancer Surveillance Consortium (BCSC) risk-prediction model while accounting for its attributable risk and compared five-year absolute risk predictions between models using area under the curve (AUC) statistics. All statistical tests were two-sided. BI-RADS density and PRS were independent risk factors across all three studies (P interaction = .23). Relative to those with scattered fibroglandular densities and average PRS (2(nd) quartile), women with extreme density and highest quartile PRS had 2.7-fold (95% confidence interval [CI] = 1.74 to 4.12) increased risk, while those with low density and PRS had reduced risk (OR = 0.30, 95% CI = 0.18 to 0.51). PRS added independent information (P < .001) to the BCSC model and improved discriminatory accuracy from AUC = 0.66 to AUC = 0.69. Although the BCSC-PRS model was well calibrated in case-control data, independent cohort data are needed to test calibration in the general population.

Published
2015

10. Genetic predisposition to in situ and invasive lobular carcinoma of the breast.

Author

Sawyer, Elinor, Roylance, Rebecca, Petridis, Christos, Brook, Mark, Nowinski, Salpie, Papouli, Efterpi, Fletcher, Olivia, Pinder, Sarah, Hanby, Andrew, Kohut, Kelly, Gorman, Patricia, Caneppele, Michele, Peto, Julian, Dos Santos Silva, Isabel, Johnson, Nichola, Swann, Ruth, Dwek, Miriam, Perkins, Katherine-Anne, Gillett, Cheryl, Houlston, Richard, Ross, Gillian, De Ieso, Paolo, Southey, Melissa, Hopper, John, Provenzano, Elena, Apicella, Carmel, Wesseling, Jelle, Cornelissen, Sten, Keeman, Renske, Fasching, Peter, Jud, Sebastian, Ekici, Arif, Beckmann, Matthias, Kerin, Michael, Marme, Federick, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Guénel, Pascal, Truong, Therese, Laurent-Puig, Pierre, Kerbrat, Pierre, Bojesen, Stig, Nordestgaard, Børge, Nielsen, Sune, Flyger, Henrik, Milne, Roger, Perez, Jose, Menéndez, Primitiva, Benitez, Javier, Brenner, Hermann, Dieffenbach, Aida, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita, Lochmann, Magdalena, Brauch, Hiltrud, Fischer, Hans-Peter, Ko, Yon-Dschun, Nevanlinna, Heli, Muranen, Taru, Aittomäki, Kristiina, Blomqvist, Carl, Bogdanova, Natalia, Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana, Chenevix-Trench, Georgia, Lambrechts, Diether, Weltens, Caroline, Van Limbergen, Erik, Hatse, Sigrid, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Volorio, Sara, Giles, Graham, Severi, Gianluca, Baglietto, Laura, McLean, Catriona, Haiman, Christopher, Henderson, Brian, Schumacher, Fredrick, Le Marchand, Loic, Simard, Jacques, Goldberg, Mark, Labrèche, France, Dumont, Martine, Kristensen, Vessela, and Winqvist, Robert

Subjects
Breast Neoplasms, Carcinoma in Situ, Carcinoma, Lobular, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Middle Aged, Polymorphism, Single Nucleotide
Abstract

Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). Genome-wide association studies have identified more than 70 common polymorphisms that predispose to breast cancer, but these studies included predominantly ductal (IDC) carcinomas. To identify novel common polymorphisms that predispose to ILC and LCIS, we pooled data from 6,023 cases (5,622 ILC, 401 pure LCIS) and 34,271 controls from 36 studies genotyped using the iCOGS chip. Six novel SNPs most strongly associated with ILC/LCIS in the pooled analysis were genotyped in a further 516 lobular cases (482 ILC, 36 LCIS) and 1,467 controls. These analyses identified a lobular-specific SNP at 7q34 (rs11977670, OR (95%CI) for ILC = 1.13 (1.09-1.18), P = 6.0 × 10(-10); P-het for ILC vs IDC ER+ tumors = 1.8 × 10(-4)). Of the 75 known breast cancer polymorphisms that were genotyped, 56 were associated with ILC and 15 with LCIS at P

Published
2014

12. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies.

Author

Yang, Xiaohong R, Chang-Claude, Jenny, Goode, Ellen L, Couch, Fergus J, Nevanlinna, Heli, Milne, Roger L, Gaudet, Mia, Schmidt, Marjanka K, Broeks, Annegien, Cox, Angela, Fasching, Peter A, Hein, Rebecca, Spurdle, Amanda B, Blows, Fiona, Driver, Kristy, Flesch-Janys, Dieter, Heinz, Judith, Sinn, Peter, Vrieling, Alina, Heikkinen, Tuomas, Aittomäki, Kristiina, Heikkilä, Päivi, Blomqvist, Carl, Lissowska, Jolanta, Peplonska, Beata, Chanock, Stephen, Figueroa, Jonine, Brinton, Louise, Hall, Per, Czene, Kamila, Humphreys, Keith, Darabi, Hatef, Liu, Jianjun, Van 't Veer, Laura J, van Leeuwen, Flora E, Andrulis, Irene L, Glendon, Gord, Knight, Julia A, Mulligan, Anna Marie, O'Malley, Frances P, Weerasooriya, Nayana, John, Esther M, Beckmann, Matthias W, Hartmann, Arndt, Weihbrecht, Sebastian B, Wachter, David L, Jud, Sebastian M, Loehberg, Christian R, Baglietto, Laura, English, Dallas R, Giles, Graham G, McLean, Catriona A, Severi, Gianluca, Lambrechts, Diether, Vandorpe, Thijs, Weltens, Caroline, Paridaens, Robert, Smeets, Ann, Neven, Patrick, Wildiers, Hans, Wang, Xianshu, Olson, Janet E, Cafourek, Victoria, Fredericksen, Zachary, Kosel, Matthew, Vachon, Celine, Cramp, Helen E, Connley, Daniel, Cross, Simon S, Balasubramanian, Sabapathy P, Reed, Malcolm WR, Dörk, Thilo, Bremer, Michael, Meyer, Andreas, Karstens, Johann H, Ay, Aysun, Park-Simon, Tjoung-Won, Hillemanns, Peter, Arias Pérez, Jose Ignacio, Menéndez Rodríguez, Primitiva, Zamora, Pilar, Benítez, Javier, Ko, Yon-Dschun, Fischer, Hans-Peter, Hamann, Ute, Pesch, Beate, Brüning, Thomas, Justenhoven, Christina, Brauch, Hiltrud, Eccles, Diana M, Tapper, William J, Gerty, Sue M, Sawyer, Elinor J, Tomlinson, Ian P, Jones, Angela, Kerin, Michael, Miller, Nicola, McInerney, Niall, Anton-Culver, Hoda, and Ziogas, Argyrios

Subjects
Humans, Breast Neoplasms, Obesity, Receptor, erbB-2, Receptors, Estrogen, Receptors, Progesterone, Body Mass Index, Logistic Models, Odds Ratio, Risk Factors, Case-Control Studies, Age Factors, Parity, Parturition, Menarche, Female, Keratin-5, ErbB Receptors, Biomarkers, Tumor, Receptor, ErbB-2, Prevention, Cancer, Aging, Breast Cancer, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundPrevious studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors.MethodsWe pooled tumor marker and epidemiological risk factor data from 35,568 invasive breast cancer case patients from 34 studies participating in the Breast Cancer Association Consortium. Logistic regression models were used in case-case analyses to estimate associations between epidemiological risk factors and tumor subtypes, and case-control analyses to estimate associations between epidemiological risk factors and the risk of developing specific tumor subtypes in 12 population-based studies. All statistical tests were two-sided.ResultsIn case-case analyses, of the epidemiological risk factors examined, early age at menarche (≤12 years) was less frequent in case patients with PR(-) than PR(+) tumors (P = .001). Nulliparity (P = 3 × 10(-6)) and increasing age at first birth (P = 2 × 10(-9)) were less frequent in ER(-) than in ER(+) tumors. Obesity (body mass index [BMI] ≥ 30 kg/m(2)) in younger women (≤50 years) was more frequent in ER(-)/PR(-) than in ER(+)/PR(+) tumors (P = 1 × 10(-7)), whereas obesity in older women (>50 years) was less frequent in PR(-) than in PR(+) tumors (P = 6 × 10(-4)). The triple-negative (ER(-)/PR(-)/HER2(-)) or core basal phenotype (CBP; triple-negative and cytokeratins [CK]5/6(+) and/or epidermal growth factor receptor [EGFR](+)) accounted for much of the heterogeneity in parity-related variables and BMI in younger women. Case-control analyses showed that nulliparity, increasing age at first birth, and obesity in younger women showed the expected associations with the risk of ER(+) or PR(+) tumors but not triple-negative (nulliparity vs parity, odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.75 to 1.19, P = .61; 5-year increase in age at first full-term birth, OR = 0.95, 95% CI = 0.86 to 1.05, P = .34; obesity in younger women, OR = 1.36, 95% CI = 0.95 to 1.94, P = .09) or CBP tumors.ConclusionsThis study shows that reproductive factors and BMI are most clearly associated with hormone receptor-positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.

Published
2011

17. Supplementary Table 6 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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18. Supplementary Tables 1 - 4 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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19. Supplementary Table 5 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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20. Supplementary Table 3 from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Author

Stone, Jennifer, primary, Thompson, Deborah J., primary, dos Santos Silva, Isabel, primary, Scott, Christopher, primary, Tamimi, Rulla M., primary, Lindstrom, Sara, primary, Kraft, Peter, primary, Hazra, Aditi, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Hall, Per, primary, Jensen, Matt, primary, Cunningham, Julie, primary, Olson, Janet E., primary, Purrington, Kristen, primary, Couch, Fergus J., primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Khaw, Kay-Tee, primary, Smith, Paula, primary, Wareham, Nicholas J., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Douglas, Julie A., primary, Shah, Kaanan P., primary, Chan, Heang-Ping, primary, Helvie, Mark A., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Apicella, Carmel, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Ursin, Giske, primary, Alnaes, Grethe I. Grenaker, primary, Kristensen, Vessela N., primary, Borresen-Dale, Anne-Lise, primary, Gram, Inger Torhild, primary, Bolla, Manjeet K., primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Dennis, Joe, primary, Simard, Jacques, primary, Pharoah, Paul, primary, Dunning, Alison M., primary, Easton, Douglas F., primary, Fasching, Peter A., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and Vachon, Celine M., primary

Published
2023
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21. Supplementary Table 1 from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Author

Stone, Jennifer, primary, Thompson, Deborah J., primary, dos Santos Silva, Isabel, primary, Scott, Christopher, primary, Tamimi, Rulla M., primary, Lindstrom, Sara, primary, Kraft, Peter, primary, Hazra, Aditi, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Hall, Per, primary, Jensen, Matt, primary, Cunningham, Julie, primary, Olson, Janet E., primary, Purrington, Kristen, primary, Couch, Fergus J., primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Khaw, Kay-Tee, primary, Smith, Paula, primary, Wareham, Nicholas J., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Douglas, Julie A., primary, Shah, Kaanan P., primary, Chan, Heang-Ping, primary, Helvie, Mark A., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Apicella, Carmel, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Ursin, Giske, primary, Alnaes, Grethe I. Grenaker, primary, Kristensen, Vessela N., primary, Borresen-Dale, Anne-Lise, primary, Gram, Inger Torhild, primary, Bolla, Manjeet K., primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Dennis, Joe, primary, Simard, Jacques, primary, Pharoah, Paul, primary, Dunning, Alison M., primary, Easton, Douglas F., primary, Fasching, Peter A., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and Vachon, Celine M., primary

Published
2023
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22. Data from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Author

Stone, Jennifer, primary, Thompson, Deborah J., primary, dos Santos Silva, Isabel, primary, Scott, Christopher, primary, Tamimi, Rulla M., primary, Lindstrom, Sara, primary, Kraft, Peter, primary, Hazra, Aditi, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Hall, Per, primary, Jensen, Matt, primary, Cunningham, Julie, primary, Olson, Janet E., primary, Purrington, Kristen, primary, Couch, Fergus J., primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Khaw, Kay-Tee, primary, Smith, Paula, primary, Wareham, Nicholas J., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Douglas, Julie A., primary, Shah, Kaanan P., primary, Chan, Heang-Ping, primary, Helvie, Mark A., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Apicella, Carmel, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Ursin, Giske, primary, Alnaes, Grethe I. Grenaker, primary, Kristensen, Vessela N., primary, Borresen-Dale, Anne-Lise, primary, Gram, Inger Torhild, primary, Bolla, Manjeet K., primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Dennis, Joe, primary, Simard, Jacques, primary, Pharoah, Paul, primary, Dunning, Alison M., primary, Easton, Douglas F., primary, Fasching, Peter A., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and Vachon, Celine M., primary

Published
2023
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23. Supplementary Table 2 from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures

Author

Stone, Jennifer, primary, Thompson, Deborah J., primary, dos Santos Silva, Isabel, primary, Scott, Christopher, primary, Tamimi, Rulla M., primary, Lindstrom, Sara, primary, Kraft, Peter, primary, Hazra, Aditi, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Hall, Per, primary, Jensen, Matt, primary, Cunningham, Julie, primary, Olson, Janet E., primary, Purrington, Kristen, primary, Couch, Fergus J., primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Khaw, Kay-Tee, primary, Smith, Paula, primary, Wareham, Nicholas J., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Douglas, Julie A., primary, Shah, Kaanan P., primary, Chan, Heang-Ping, primary, Helvie, Mark A., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Apicella, Carmel, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Ursin, Giske, primary, Alnaes, Grethe I. Grenaker, primary, Kristensen, Vessela N., primary, Borresen-Dale, Anne-Lise, primary, Gram, Inger Torhild, primary, Bolla, Manjeet K., primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Dennis, Joe, primary, Simard, Jacques, primary, Pharoah, Paul, primary, Dunning, Alison M., primary, Easton, Douglas F., primary, Fasching, Peter A., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and Vachon, Celine M., primary

Published
2023
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24. Erratum: Mammakarzinom beim Mann

Author

Preuss, Caroline, additional, Wunderle, Marius, additional, Hack, Carolin C., additional, Beckmann, Matthias W., additional, Wenkel, Evelyn, additional, Jud, Sebastian, additional, and Heindl, Felix, additional

Published
2023
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25. Mammakarzinom beim Mann

Author

Preuss, Caroline, additional, Wunderle, Marius, additional, Hack, Carolin C., additional, Beckmann, Matthias W., additional, Wenkel, Evelyn, additional, Jud, Sebastian, additional, and Heindl, Felix, additional

Published
2023
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27. Gynecologic oncologists’ attitudes and practices relating to integrative medicine: results of a nationwide AGO survey

Author

Klein, Evelyn, Beckmann, Matthias W., Bader, Werner, Brucker, Cosima, Dobos, Gustav, Fischer, Dorothea, Hanf, Volker, Hasenburg, Annette, Jud, Sebastian M., Kalder, Matthias, Kiechle, Marion, Kümmel, Sherko, Müller, Andreas, Müller, Myrjam-Alice T., Paepke, Daniela, Rotmann, Andre-Robert, Schütz, Florian, Scharl, Anton, Voiss, Petra, Wallwiener, Markus, Witt, Claudia, and Hack, Carolin C.

Published
2017
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28. Association of molecular subtypes with breast cancer risk factors : a case-only analysis

Author

Rauh, Claudia, Gass, Paul, Heusinger, Katharina, Haeberle, Lothar, Jud, Sebastian M., Hein, Alexander, Loehberg, Christian R., Lux, Michael P., Wachter, David L., Heimrich, Jutta, Strehl, Johanna D., Haller, Florian, Hartmann, Arndt, Schulz-Wendtland, Ruediger, Fiessler, Cornelia, Beckmann, Matthias W., Fasching, Peter A., and Poehls, Uwe

Published
2015

30. Filtration based assessment of CTCs and CellSearch® based assessment are both powerful predictors of prognosis for metastatic breast cancer patients

Author

Huebner, Hanna, Fasching, Peter A., Gumbrecht, Walter, Jud, Sebastian, Rauh, Claudia, Matzas, Mark, Paulicka, Peter, Friedrich, Katja, Lux, Michael P., Volz, Bernhard, Gass, Paul, Häberle, Lothar, Meier-Stiegen, Franziska, Hartkopf, Andreas, Neubauer, Hans, Almstedt, Katrin, Beckmann, Matthias W., Fehm, Tanja N., and Ruebner, Matthias

Published
2018
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31. Factors influencing breast changes after pregnancy

Author

Rauh, Claudia, Faschingbauer, Florian, Haeberle, Lothar, Jud, Sebastian M., Heusinger, Katharina, Fasching, Peter A., Goecke, Tamme W., Rajakaruna, Nadeeka, Voigt, Franziska, Bani, Mayada R., Lux, Michael P., Renner, Stefan P., Loehberg, Christian R., Hartmann, Arndt, Schulz-Wendtland, Ruediger, Beckmann, Matthias W., and Bayer, Christian M.

Published
2013

32. Hormone replacement therapy and prognosis in ovarian cancer patients

Author

Hein, Alexander, Thiel, Falk C., Bayer, Christian M., Fasching, Peter A., Häberle, Lothar, Lux, Michael P., Renner, Stefan P., Jud, Sebastian M., Schrauder, Michael G., Müller, Andreas, Wachter, David, Strehl, Johanna, Hartmann, Arndt, Beckmann, Matthias W., and Rauh, Claudia

Published
2013

33. Mammakarzinom beim Mann.

Author

Preuss, Caroline, Wunderle, Marius, Hack, Carolin C., Beckmann, Matthias W., Wenkel, Evelyn, Jud, Sebastian Michael, and Heindl, Felix

Published
2023
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35. Mammographic density as a risk factor for breast cancer in a German case–control study

Author

Heusinger, Katharina, Loehberg, Christian R., Haeberle, Lothar, Jud, Sebastian M., Klingsiek, Peter, Hein, Alexander, Bayer, Christian M., Rauh, Claudia, Uder, Michael, Cavallaro, Alexander, May, Matthias S., Adamietz, Boris, Schulz-Wendtland, Ruediger, Wittenberg, Thomas, Wagner, Florian, Beckmann, Matthias W., and Fasching, Peter A.

Published
2011

36. RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women

Author

Wunderle, Marius, Ruebner, Matthias, Häberle, Lothar, Schwenke, Eva, Hack, Carolin C., Bayer, Christian M., Koch, Martin C., Schwitulla, Judith, Schulz-Wendtland, Ruediger, Kozieradzki, Ivona, Lux, Michael P., Beckmann, Matthias W., Jud, Sebastian M., Penninger, Josef M., Schneider, Michael O., and Fasching, Peter A.

Subjects
musculoskeletal diseases, lcsh:R, lcsh:Medicine, lcsh:Q, ddc:610, skin and connective tissue diseases, lcsh:Science
Abstract

Breast cancer risk is reduced by number of pregnancies and breastfeeding duration, however studies of breast changes during or after pregnancy are rare. Breast volume changes – although not linked to breast cancer risk – might be an interesting phenotype in this context for correlative studies, as changes of breast volume vary between pregnant women. Serum receptor activator of nuclear factor kappa B ligand (RANKL) and its antagonist osteoprotegerin (OPG) were measured prospectively before gestational week 12, and three-dimensional breast volume assessments were performed. A linear regression model including breast volume at the start of pregnancy, RANKL, OPG, and other factors was used to predict breast volume at term. The mean breast volume was 413 mL at gestational week 12, increasing by a mean of 99 mL up to gestational week 40. In addition to body mass index and breast volume at the beginning of pregnancy, RANKL and OPG appeared to influence breast volume with a mean increase by 32 mL (P = 0.04) and a mean reduction by 27 mL (P = 0.04), respectively. Linking the RANKL/RANK/OPG pathway with breast volume changes supports further studies aiming at analysing breast changes during pregnancy with regard to breast cancer risk.

Published
2020
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37. Assessment of mammographic density before and after first full-term pregnancy

Author

Loehberg, Christian R., Heusinger, Katharina, Jud, Sebastian M., Haeberle, Lothar, Hein, Alexander, Rauh, Claudia, Bani, Mayada R., Lux, Michael P., Schrauder, Michael G., Bayer, Christian M., Helbig, Cosima, Grolik, Ronald, Adamietz, Boris, Schulz-Wendtland, Ruediger, Beckmann, Matthias W., and Fasching, Peter A.

Published
2010

38. Epidemiology, risk factors, and genetics of endometrial cancer

Author

Tempfer, Clemens, Steinke-Lange, Verena, Aretz, Stefan, Schmutzler, Rita, Ortmann, Olaf, Roemer, Thomas, Hanf, Volker, Widhalm, Simone, Reents, Nicola, Jud, Sebastian, Kommoss, Stefan, Nothacker, Monika, Bloedt, Susanne, Tempfer, Clemens, Steinke-Lange, Verena, Aretz, Stefan, Schmutzler, Rita, Ortmann, Olaf, Roemer, Thomas, Hanf, Volker, Widhalm, Simone, Reents, Nicola, Jud, Sebastian, Kommoss, Stefan, Nothacker, Monika, and Bloedt, Susanne

Abstract

Background Endometrial cancer (EC) is the fifth most common female malignancy and the most common pelvic malignancy. Effective strategies for early detection, prevention, and genetic assessment are discussed in this article. Aim To review the literature on epidemiology, risk factors, and genetics. Materials and Methods This article is based on the current recommendations of the German Society of Obstetrics and Gynecology for the diagnosis and treatment of women with EC. The current literature was summarized based on expert knowledge. Systematic searches in the Medline database and in Cochrane Reviews were performed. The quality of the evidence was rated according to the 2011 Oxford classification. Recommendations and statements were formulated by a representative group using structured consensus methods. Results In Germany, 2.7% of cancer-specific deaths are due to EC. The incidence of EC increases with age and the disease is most often diagnosed in the age group of 75- to 79-year-old women. The lifetime risk of EC is 1.9%. Risk-modulating factors of EC include long-term use of estrogens, progestogen therapy, oral contraceptives, high body mass index, and impaired glucose metabolism. In addition, physical activity and dietary aspects, such as the amount of fat and red meat consumed, as well as soja foods, dietary fibers, vitamins, and specific beverages such as tea and coffee, play an important etiological role. EC also has a genetic component. Immunohistochemical and/or molecular screening is warranted for all patients with EC and has a significant impact on the genetic counselling of affected families as well as on treatment decisions.

Published
2022

44. Prognostic relevance of Ki-67 in the primary tumor for survival after a diagnosis of distant metastasis

Author

Loehberg, Christian R., Almstedt, Katrin, Jud, Sebastian M., Haeberle, Lothar, Fasching, Peter A., Hack, Carolin C., Lux, Michael P., Thiel, Falk C., Schrauder, Michael G., Brunner, Michaela, Bayer, Christian M., Hein, Alexander, Heusinger, Katharina, Heimrich, Jutta, Bani, Mayada R., Renner, Stefan P., Hartmann, Arndt, Beckmann, Matthias W., and Wachter, David L.

Published
2013
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45. Financing of certified centers: a willingness-to-pay analysis

Author

Thiel, Falk C., Scharl, Anton, Hildebrandt, Thomas, Kotziabassis, Efstratios, Schrauder, Michael G., Bani, Mayada R., Müller, Andreas, Hauzenberger, Tanja, Loehberg, Christian R., Jud, Sebastian M., Fasching, Peter A., Hartmann, Arndt, Schulz-Wendtland, Rüdiger, Strnad, Vratislav, Beckmann, Matthias W., and Lux, Michael Patrick

Published
2013
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46. Pathologie ausgewählter epithelialer Neoplasien der Brust – Teil 2

Author

Erber, Ramona, additional, Grasruck, Katharina, additional, Lange, Fabienne, additional, Hartmann, Arndt, additional, Schulz-Wendtland, Rüdiger, additional, Preuß, Caroline, additional, Wunderle, Marius, additional, Jud, Sebastian M., additional, Fasching, Peter A., additional, Beckmann, Matthias W., additional, and Hack, Carolin C., additional

Published
2021
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47. Pathologie ausgewählter epithelialer Neoplasien der Brust – Teil 1

Author

Erber, Ramona, additional, Grasruck, Katharina, additional, Lange, Fabienne, additional, Hartmann, Arndt, additional, Schulz-Wendtland, Rüdiger, additional, Preuß, Caroline, additional, Wunderle, Marius, additional, Jud, Sebastian M., additional, Fasching, Peter A., additional, Beckmann, Matthias W., additional, and Hack, Carolin C., additional

Published
2021
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48. Association of mammographic density with the proliferation marker Ki-67 in a cohort of patients with invasive breast cancer

Author

Heusinger, Katharina, Jud, Sebastian M., Häberle, Lothar, Hack, Carolin C., Fasching, Peter A., Meier-Meitinger, Martina, Lux, Michael P., Hagenbeck, Carsten, Loehberg, Christian R., Wittenberg, Thomas, Rauh, Claudia, Wagner, Florian, Uder, Michael, Hartmann, Arndt, Schulz-Wendtland, Rüdiger, Beckmann, Matthias W., and Wachter, David L.

Published
2012
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