644 results on '"Judd, H"'
Search Results
2. Anterior-posterior diameter is a key driver of resectability and complications for pituitary adenomas with suprasellar extension in endoscopic transsphenoidal surgery
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Park, Jung, Golub, Danielle, White, Timothy G., Ruelle, Marianne, Quach, Eric T., Yang, Kaiyun, Shah, Harshal A., Fastenberg, Judd H., Eisenberg, Mark B., and Dehdashti, Amir R.
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- 2023
- Full Text
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3. Severe injuries from product movement in the U.S. food supply chain
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Michael, Judd H. and Gorucu, Serap
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- 2023
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4. Endoscopic Transsphenoidal Resection of a Retro-Infundibular Craniopharyngioma with Preservation of the Pituitary Stalk: Two-Dimensional Endoscopic Video.
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Kuffer, Alexander F., Golub, Danielle, Chaskes, Mark B., Fastenberg, Judd H., and Dehdashti, Amir R.
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ENDOSCOPIC surgery ,CRANIOPHARYNGIOMA ,PITUITARY gland ,VIDEOS ,TUMORS - Abstract
The article in the Journal of Neurological Surgery. Part B. Skull Base, published on February 2, 2025, presents a 2-dimensional endoscopic video showcasing the successful resection of a retro-infundibular craniopharyngioma while preserving the pituitary stalk. The surgical approach involved removing the bony sellar face, tuberculum, and planum for enhanced visualization, followed by careful tumor removal behind the right side of the pituitary stalk to maintain normal pituitary gland function. The authors, Alexander F. Kuffer, Danielle Golub, Mark B. Chaskes, Judd H. Fastenberg, and Amir R. Dehdashti, reported on this procedure. [Extracted from the article]
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- 2025
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5. Surgical Resection for Microprolactinomas after Failed Medical Management: An International Multi-institutional Series.
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Golub, Danielle, White, Timothy G., Shah, Harshal A., Khaleghi, Mehdi, Huntoon, Kristin M., Zandbergen, Ingrid M., Bakker, Leontine E., Ghalib, Luma M., Pelsma, Iris C., Dowlati, Ehsan, Chaskes, Mark B., Fastenberg, Judd H., Verstegen, Marco J., Biermasz, Nienke R., Prevedello, Daniel M., and Dehdashti, Amir R.
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DIABETES insipidus ,ACADEMIC medical centers ,CEREBROSPINAL fluid leak ,PITUITARY tumors ,PATIENT preferences - Abstract
This article discusses the use of endoscopic endonasal surgery (EES) as an alternative treatment for microprolactinomas, which are small pituitary tumors. The study, conducted at multiple medical centers in the United States and the Netherlands, found that EES had a surgical cure rate of nearly 70% for microprolactinomas. The main predictor of surgical success was achieving gross total resection of the tumor, with minimal complications reported. The study highlights the potential of EES as a viable option for patients who are unable to tolerate long-term dopamine agonist therapy for microprolactinomas. [Extracted from the article]
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- 2025
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6. Recurrent Sinonasal Squamous Cell Carcinoma: Current Insights and Treatment Advances.
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Kravitz, Meryl B., Annadata, Vivek, Ilyaev, Benjamin, Tong, Charles C. L., Fastenburg, Judd H., and Chaskes, Mark B.
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SQUAMOUS cell carcinoma ,PARANASAL sinus cancer ,CANCER relapse ,SALVAGE therapy ,CHEMORADIOTHERAPY - Abstract
Simple Summary: Squamous cell carcinoma (SCC) is the most common cancer affecting the sinonasal tract. Unfortunately, it has a high rate of recurrence, affecting nearly half of patients who are initially treated. Nonetheless, there are limited guidelines for diagnosing and managing recurrent disease. This review discusses diagnosis, prognostic factors, and available treatment algorithms for recurrent cases. For eligible patients, surgery remains the most effective long-term treatment. When surgery is not an option, chemotherapy and radiation are used either to help control the disease or to ease symptoms. Newer treatments, such as immunotherapy and advanced radiation techniques, are being actively researched as promising alternatives. Squamous cell carcinoma is the most common malignancy affecting the sinonasal tract. Local recurrence is the main pattern of treatment failure, affecting nearly half of patients treated for primary sinonasal squamous cell carcinoma (SNSCC). Due to disease rarity and heterogeneity of practices, there are limited guidelines for how to diagnose and care for these patients. This paper reviews current evidence regarding etiology, pathophysiology, diagnosis, prognostic factors, and treatment modalities of recurrent SNSCC (rSNSCC). Currently, salvage surgery offers the only durable approach for eligible patients. These resections often require robust reconstructive options due to prior surgery or radiation. Chemoradiation is offered as an adjuvant or palliative approach when surgery is not a feasible option. Emerging options such as immunotherapy and particle therapy remain an area of ongoing investigation. [ABSTRACT FROM AUTHOR]
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- 2025
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7. The impact of the COVID-19 pandemic on otolaryngologic emergency department visits at two major NYC hospital systems
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Patel, Viraj M., Kominsky, Evan, Tham, Tristan, Bottalico, Danielle, Setzen, Michael, Ferastraoaru, Denisa, Akbar, Nadeem, and Fastenberg, Judd H.
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- 2021
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8. Non-occupational injuries caused by transport packaging: Residential and retail hazards
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Michael, Judd H. and Gorucu, Serap
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- 2021
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9. Endoscopic Sinus Surgery for Pediatric Patients
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Fastenberg, Judd H., Weinstock, Michael S., Bent, John P., Ramadan, Hassan H., editor, and Baroody, Fuad M., editor
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- 2020
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10. Functional and radiological sinonasal outcomes of CFTR modulators for sinus disease in cystic fibrosis: A meta‐analysis.
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Tham, Tristan, Li, Felisha A., Schneider, Jacob R., Saleem, Matthew I., Werner, Michael T., Chaskes, Mark B., Tong, Charles C. L., and Fastenberg, Judd H.
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- 2024
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11. Management of Nonfunctioning Recurrent Pituitary Adenomas
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Farrell, Christopher J., Garzon-Muvdi, Tomas, Fastenberg, Judd H., Nyquist, Gurston G., Rabinowitz, Mindy R., Rosen, Marc R., and Evans, James J.
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- 2019
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12. Onyx or Glue? A Representative Case Comparison of Embolic Agents for Direct Puncture Embolization of Juvenile Nasopharyngeal Angiofibroma
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Dhar, Sarit, additional, Lee, Alice, additional, Chaskes, Mark B., additional, Dehdashti, Amir R., additional, Elijovich, Lucas, additional, Michael, L. Madison, additional, Patsalides, Athos, additional, Rangarajan, Sanjeet V., additional, and Fastenberg, Judd H., additional
- Published
- 2024
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13. Transcutaneous Retrobulbar Amphotericin B Injection for Invasive Fungal Sinusitis with Orbital Involvement: A Systematic Review.
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Abdulbaki, Hasan, Callander, Jacquelyn K., Fastenberg, Judd H., Russell, Matthew S., Vagefi, M. Reza, Kersten, Robert C., and Loftus, Patricia A.
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AMPHOTERICIN B ,PROGNOSIS ,COVID-19 pandemic ,VISUAL acuity ,WEB databases ,MUCORMYCOSIS - Abstract
Background: Orbital involvement of invasive fungal sinusitis (IFS) is an ominous prognostic marker that should prompt rapid intervention. Transcutaneous retrobulbar administration of amphotericin B (TRAMB) is an off-label adjunctive treatment that can increase drug penetrance into diseased orbital tissue. To date, there is a lack of consensus regarding the use of TRAMB for treatment of IFS with orbital involvement. Objective: This systematic review aims to synthesize the indications, efficacy, and potential complications of TRAMB. Methods: PubMed, EMBASE, and Web of Science databases were probed for systematic review. Article search was conducted through June 2023 using the keywords "invasive fungal sinusitis," "invasive fungal rhinosinusitis," "rhino-orbital mucormycosis," "rhinosinusitis," "orbital," "retrobulbar," and "amphotericin." Results: In suitable cases as determined by radiologic and clinical evaluation, TRAMB administration has the potential to improve orbital salvage rates and improve versus stabilize visual acuity. Treatment complications are more likely with deoxycholate than with liposomal amphotericin formulations. The existing literature describing use of TRAMB is limited due to its retrospective nature, but the increase in IFS cases since 2020 due to the COVID pandemic has broadened the literature. Conclusions: TRAMB is an effective adjunctive treatment in IFS with mild-to-moderate orbital involvement when used in combination with standard of care debridement, systemic antifungal therapy, and immunosuppression reversal. Prospective longitudinal studies and multi-institutional randomized trials are necessary to determine the definitive utility of TRAMB. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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14. Combined Direct Tumoral Puncture Embolization with Onyx and Trans‐arterial Embolization for JNA.
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Fastenberg, Judd H., Al‐Mulki, K., Chaskes, M.B., Tong, C.C.L., Kutcher Diaz, R., Shah, K., and Patsalides, A.
- Abstract
This article discusses the use of a tandem approach combining trans-arterial embolization (TAE) with direct puncture embolization (DPE) using Onyx, an embolic agent, for the treatment of juvenile nasopharyngeal angiofibroma (JNA). JNA is a rare tumor that primarily affects adolescent males and can be locally invasive. Surgical excision is the primary treatment, but the hypervascular nature of JNA can make resection challenging. The authors present their experience with the tandem approach and provide a protocol and technical pearls for its implementation. The article includes a video illustrating the technique. Six patients were treated using this approach, and the results showed no recurrence of the tumor. [Extracted from the article]
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- 2024
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15. Contributors
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Ahmed, Omar H., primary, Ansari, Shaheryar F., additional, Arko, Leopold, additional, Banks, Catherine, additional, Barkhoudarian, Garni, additional, Biglioli, Federico, additional, Bleier, Benjamin S., additional, Boahene, Kofi, additional, Borghei-Ravazi, Hamid, additional, Cappello, Zachary J., additional, Carniciu, Anais L., additional, Carrau, Ricardo L., additional, Cassidy, Matthew, additional, Chandra, Rakesh, additional, Chitguppi, Chandala, additional, Chon, Brian H., additional, Colletti, Giacomo, additional, Coy, Gustavo, additional, Dallan, Iacopo, additional, Deere, Jackson, additional, Dewart, Nora, additional, Dowling, Eric M., additional, Ebert, Charles S., additional, Eloy, Jean Anderson, additional, Evans, James J., additional, Farber, Nicole I., additional, Farrell, Nyssa Fox, additional, Fastenberg, Judd H., additional, Felisati, Giovanni, additional, Fernandez-Miranda, Juan C., additional, Gardner, Paul A., additional, Gazit, Inbal, additional, Georgalas, Christos, additional, Godfrey, Kyle J., additional, Goldschmidt, Ezequiel, additional, Grayson, Jessica W., additional, Halderman, Ashleigh A., additional, Hardesty, John F., additional, Hartstein, Morris E., additional, Harvey, Richard J., additional, Hernandez, Stephen C., additional, Hink, Eric, additional, Holds, John Bryan, additional, Hsueh, Wayne D., additional, Hwang, Catherine J., additional, Karakasis, Christopher, additional, Kazim, Michael, additional, Kelly, Daniel F., additional, Kelly, Kathleen M., additional, Kimple, Adam J., additional, Kingdom, Todd T., additional, Kraus, Courtney Lynn, additional, Kraus, Howard, additional, Kshettry, Varun R., additional, Kuan, Edward C., additional, Lane, Andrew P., additional, Lanza, Donald Charles, additional, Lee, Victoria S., additional, Lenzi, Riccardo, additional, Liu, James K., additional, Lystad, Lisa D., additional, Maamari, Robi Nicolas, additional, Mangussi-Gomes, João, additional, Metson, Ralph B., additional, Mishra, Kapil, additional, Mitchell, Ron, additional, Moe, Kris S., additional, Muscatello, Luca, additional, Nair, Dileep, additional, Nguyen, John, additional, Novinger, Leah, additional, Nyquist, Gurston G., additional, Or, Lior, additional, Palmer, James N., additional, Perry, Julian D., additional, Piniara, Anastasia, additional, Prevedello, Daniel M., additional, Rabinowitz, Mindy R., additional, Ramadan, Hassan, additional, Recinos, Pablo F., additional, Rivera, Roxana Y., additional, Rosen, Marc R., additional, Roxbury, Christopher R., additional, Ruggieri, Paul, additional, Saadeh, Charles, additional, Sacks, Raymond, additional, Sagar, Soumya, additional, Saibene, Alberto Maria, additional, Santarelli, Griffin D., additional, Schaefer, Jamie Lea, additional, Schwartz, Theodore H., additional, Sen, Rajeev D., additional, Shah, Gopi, additional, Sindwani, Raj, additional, Singh, Arun D., additional, Snyderman, Carl H., additional, Stamm, Aldo C., additional, Stammberger, Heinz, additional, Stokken, Janalee K., additional, Succar, Eric, additional, Svider, Peter F., additional, Tarrats, Luisam, additional, Thorp, Brian D., additional, Ting, Jonathan Y., additional, Tomazic, Peter Valentin, additional, VanKoevering, Kyle K., additional, Vyskocil, Erich, additional, Wang, Eric W., additional, Witterick, Ian J., additional, Wormald, Peter J., additional, Zalzal, Habib, additional, and Zanation, Adam M., additional
- Published
- 2021
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16. Endoscopic Endonasal Approaches to the Optic Apparatus: Technique and Pathology
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Chitguppi, Chandala, primary, Fastenberg, Judd H., additional, Nyquist, Gurston G., additional, Rosen, Marc R., additional, Evans, James J., additional, and Rabinowitz, Mindy R., additional
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- 2021
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17. Novel use of video glasses during binocular microscopy in the otolaryngology clinic
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Fastenberg, Judd H., Fang, Christina H., Akbar, Nadeem A., Abuzeid, Waleed M., and Moskowitz, Howard S.
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- 2018
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18. Orientation of the premaxilla in the origin of septal deviation
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Hyman, Ari J., Fastenberg, Judd H., and Stupak, Howard D.
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- 2019
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19. A Voxel-Based Individual Tree Stem Detection Method Using Airborne LiDAR in Mature Northeastern U.S. Forests.
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Jeff L. Hershey, Marc E. McDill, Douglas A. Miller, Brennan Holderman, and Judd H. Michael
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- 2022
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20. Endoscopic Sinus Surgery for Pediatric Patients
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Fastenberg, Judd H., primary, Weinstock, Michael S., additional, and Bent, John P., additional
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- 2019
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21. Calcium plus vitamin D supplementation and the risk of colorectal cancer: Commentary
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Wactawski-Wende, J, Kotchen, JM, Anderson, GL, Assaf, AR, Brunner, RL, O'sullivan, MJ, Margolis, KL, Ockene, JK, Phillips, L, Pottern, L, Prentice, RL, Robbins, J, Rohan, TE, Sarto, GE, Sharma, S, Stefanick, ML, Van Horn, L, Wallace, RB, Whitlock, E, Bassford, T, Beresford, SAA, Black, HR, Bonds, DE, Brzyski, RG, Caan, B, Chlebowski, RT, Cochrane, B, Garland, C, Gass, M, Hays, J, Heiss, G, Hendrix, SL, Howard, BV, Hsia, J, Hubbell, FA, Jackson, RD, Johnson, KC, Judd, H, Kooperberg, CL, Kuller, LH, Lacroix, AZ, Lane, DS, Langer, RD, Lasser, NL, Lewis, CE, Limacher, MC, and Manson, JE
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Nutrition ,Complementary and Alternative Medicine ,Aging ,Prevention ,Digestive Diseases ,Biomedical Imaging ,Clinical Trials and Supportive Activities ,Colo-Rectal Cancer ,Clinical Research ,Cancer ,3.3 Nutrition and chemoprevention ,6.1 Pharmaceuticals ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine - Published
- 2006
22. Introductory TORS training in an otolaryngology residency program
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Fastenberg, Judd H., Gibber, Marc J., and Smith, Richard V.
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- 2018
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23. Management of Orbital Masses: Outcomes of Endoscopic and Combined Approaches With No Orbital Reconstruction
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Ryan A. Rimmer MD, Alexander E. Graf BA, Judd H. Fastenberg MD, Jurij Bilyk MD, Gurston G. Nyquist MD, Marc R. Rosen MD, Michael P. Rabinowitz MD, and Mindy R. Rabinowitz MD
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Otorhinolaryngology ,RF1-547 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Introduction The endoscopic endonasal approach to management of orbital pathology has expanded. Due to the rarity of these conditions, most reports in the literature consist of small case reports. We report a series from a single institution with a focus on outcomes. Methods A retrospective chart review was carried out between 2010 and 2018. Results Twenty-four patients were identified (average age 58 years, 15 males, 9 females). Average follow-up was 14.9 months. Most common etiologies included cavernous hemangioma (7), metastases (6), idiopathic orbital inflammatory syndrome (6), orbital hematoma/clot (2), and schwannoma (1). Most common presenting symptoms were decreased visual acuity (8), proptosis (8), diplopia (7), and incidental findings (2). All patients underwent endoscopic medial wall orbital decompressions. Sixteen involved a combined open approach by an ophthalmologist. Pathology was either biopsied (15), resected (6), or could not be identified (3). No intraoperative complications were noted. No patients underwent orbital reconstruction of the medial wall. Six patients developed postoperative sinusitis successfully managed with antibiotics. One patient developed epistaxis managed conservatively. In 5 patients, Sino-Nasal Outcome Test-22 scores increased immediately postop and then decreased, whereas scores only decreased in 6 patients. Six patients noted reduced proptosis. There were no new cases of diplopia or worsening visual acuity. Conclusions A combined endoscopic endonasal and external approach can be useful for managing orbital lesions. Patients tolerated the procedure well with improvement in ocular symptoms and minimal sinonasal complications. Reconstruction of the medial wall may not be warranted to prevent postoperative diplopia.
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- 2020
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24. Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies
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Fastenberg, Judd H., Hsueh, Wayne D., Mustafa, Ali, Akbar, Nadeem A., and Abuzeid, Waleed M.
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- 2016
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25. Coblation-assisted management of pediatric airway stenosis
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Fastenberg, Judd H., Roy, Soham, and Smith, Lee P.
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- 2016
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26. Reconstruction of the Anterior Skull Base Using the Nasoseptal Flap: A Review.
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Werner, Michael T., Yeoh, Desmond, Fastenberg, Judd H., Chaskes, Mark B., Pollack, Aron Z., Boockvar, John A., Langer, David J., D'Amico, Randy S., Ellis, Jason A., Miles, Brett A., and Tong, Charles C. L.
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SURGICAL flaps ,ENDOSCOPIC surgery ,CONVALESCENCE ,PLASTIC surgery ,PRODUCT design ,QUALITY assurance ,SKULL base ,ENDOSCOPY - Abstract
Simple Summary: Patients with pituitary tumors and other masses at the bottom of the skull are at risk of brain infection and leaks of the fluid surrounding the brain when the tumor is removed surgically. To prevent these types of complications, surgeons have developed techniques to patch the surgical area with normal tissue taken from other parts of the body. In the past, this tissue was taken from the head, neck, and shoulder regions. Newer techniques allow the entire surgery to occur within the nose, resulting in fewer side effects and faster recovery. This includes taking normal tissue from within the nose to repair the base of the skull where the mass is removed. The nasoseptal flap is the most common method for this type of intranasal repair. In this paper, we describe the development and evolution of this surgical technique and discuss the impact that it has had on patient outcomes. The nasoseptal flap is a workhorse reconstructive option for anterior skull base defects during endonasal surgery. This paper highlights the versatility of the nasoseptal flap. After providing a brief historical perspective, this review will focus on the relevant primary literature published in the last ten years. We will touch upon new applications of the flap, how the flap has been modified to expand its reach and robustness, and some of the current limitations. We will conclude by discussing what the future holds for improving upon the design and use of the nasoseptal flap in anterior skull base reconstruction. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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27. Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III)
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Shehabi, Yahya, primary, Serpa Neto, Ary, additional, Bellomo, Rinaldo, additional, Howe, Belinda D., additional, Arabi, Yaseen M., additional, Bailey, Michael, additional, Bass, Frances E., additional, Bin Kadiman, Suhaini, additional, McArthur, Colin J., additional, Reade, Michael C., additional, Seppelt, Ian M., additional, Takala, Jukka, additional, Wise, Matt P., additional, Webb, Steve A., additional, Mashonganyika, C., additional, McKee, H., additional, Tonks, A., additional, Donnelly, A., additional, Hemmings, N., additional, O’Kane, S., additional, Blakemore, A., additional, Butler, M., additional, Cowdrey, K., additional, Dalton, J., additional, Gilder, E., additional, Long, S., additional, McCarthy, L., additional, McGuinness, S., additional, Parke, R., additional, Chen, Y., additional, McArthur, C., additional, McConnochie, R., additional, Newby, L., additional, Bellomo, R., additional, Eastwood, G., additional, Peck, L., additional, Young, H., additional, Boschert, C., additional, Edington, J., additional, Fletcher, J., additional, Smith, J., additional, Nand, K., additional, Raza, A., additional, Sara, T., additional, Bennett-Britton, J., additional, Bewley, J., additional, Bodenham, V., additional, Cole, L., additional, Driver, K., additional, Grimmer, L., additional, Howie, L., additional, Searles, C., additional, Sweet, K., additional, Webster, D., additional, van Berkel, A., additional, Connor, H., additional, Dennett, J., additional, van Der Graaff, M., additional, Henderson, S., additional, Mehrtens, J., additional, Miller, K., additional, Minto, E., additional, Morris, A., additional, Noble, S., additional, Parker, K., additional, Bulfin, L., additional, Hart, N., additional, Shepherd, K., additional, Vij, S., additional, Dickson, S., additional, Elloway, E., additional, Ferguson, C., additional, Jackson, R., additional, MacNaughton, P., additional, Marner, M., additional, Squire, R., additional, Waddy, S., additional, Wafer, P., additional, Welbourne, J., additional, Ashcroft, P., additional, Chambler, D., additional, Dukes, S., additional, Harris, A., additional, Horton, S., additional, Sharpe, S., additional, Williams, P., additional, Williams, S., additional, Bailey, M., additional, Blazquez, E., additional, France, D., additional, Hutchison, R., additional, O’Connor, A., additional, Comadira, G., additional, Gough, M., additional, Tallott, M., additional, Bastick, M., additional, Cameron, R., additional, Donovan, S., additional, Ellis, K., additional, Gaur, A., additional, Gregory, R., additional, Naumoff, J., additional, Turner, E., additional, White, M., additional, Au, K. F. J., additional, Fratzia, J., additional, Treloar, S., additional, Lim, C. H., additional, Maseeda, Y., additional, Tan, A. P., additional, Tang, C. L., additional, Yong, C. Y., additional, Akaltan, M., additional, Berger, S., additional, Blaser, D., additional, Fazlija, L., additional, Jong, M. L., additional, Lensch, M., additional, Ludwig, R., additional, Merz, T., additional, Nettelbeck, K., additional, Roth, M., additional, Schafer, M., additional, Takala, J., additional, Wehr, A., additional, Zacharias, D., additional, Amran, R., additional, Ashraf, H. N., additional, Azmi, N., additional, Basri, N., additional, Burhanuddin, H., additional, Hadinata, Y., additional, Hamdan, A., additional, Kadiman, S., additional, Rashid, A. I. Y. M., additional, Sabran, I. N., additional, Sulaiman, S., additional, Zabidi, I. N., additional, Al-Dawood, A., additional, Aljuaid, M., additional, Anizi, H. Al, additional, Saeedi, A. Al, additional, Arabi, Y., additional, Dbsawy, M., additional, Deeb, A., additional, Hegazy, M., additional, Magdi, I., additional, Clarey, E., additional, Corcoran, E., additional, Finney, C., additional, Harris, C., additional, Hopkins, P., additional, Noble, H., additional, Thompson, L., additional, Williams, T., additional, Dumlao, L. A., additional, Bassam, R., additional, Hassan, M. A., additional, Naseem, N., additional, Al-Kurdi, M. H., additional, Al-Harthy, A. M., additional, Bernard, S., additional, Sebafundi, L., additional, Serban, C., additional, Lim, S. K., additional, Mazidah, N., additional, Saidin, N., additional, Sjamsuddin, N., additional, Tan, I. T. A., additional, Zabidi, N., additional, Brain, M., additional, Mineall, S., additional, Kanhere, M., additional, Soar, N., additional, Kadir, N. Abd, additional, Abdullah, N. H., additional, Awang, R., additional, Emperan, Z., additional, Husin, N. S., additional, Ismail, N. I., additional, Ismail, S. Z., additional, Khadzali, F. N. A. Mohd, additional, Norddin, M. F., additional, Aguila, J., additional, Bold, C., additional, Clatworthy, B., additional, Dias, A., additional, Hogan, C., additional, Kazemi, A., additional, Lai, V., additional, Song, R., additional, Williams, A., additional, Bhatia, D., additional, Elliot, S., additional, Galt, P., additional, Lavrans, K., additional, Ritchie, P., additional, Wang, A., additional, Gresham, R., additional, Lowrey, J., additional, Masters, K., additional, Palejs, P., additional, Seppelt, I., additional, Symonds, F., additional, Weisbrodt, L., additional, Whitehead, C., additional, Babio-Galan, M., additional, Calder, V., additional, Clement, I., additional, Harrison, A., additional, McCullagh, I., additional, Scott, C., additional, Bevan, R., additional, Caniba, S., additional, Hacking, D., additional, Maher, L., additional, Azzolini, M. L., additional, Beccaria, P., additional, Colombo, S., additional, Landoni, G., additional, Leggieri, C., additional, Luca, C., additional, Mamo, D., additional, Moizo, E., additional, Monti, G., additional, Mucci, M., additional, Zangrillo, A., additional, Albania, M., additional, Arora, S., additional, Shi, Y., additional, Abudayah, A., additional, Almekhlafi, G., additional, Al Amodi, E., additional, Al Samarrai, S., additional, Badawi, M., additional, Caba, R. Cubio, additional, Elffaki, O., additional, Mandourah, Y., additional, Valerio, J., additional, Joyce, C., additional, Meyer, J., additional, Saylor, E., additional, Venkatesh, B., additional, Venz, E., additional, Walsham, J., additional, Wetzig, K., additional, Khoo, T. M., additional, Liew, J. E. S., additional, Sakthi, A. N., additional, Zulkurnain, A., additional, Bamford, A., additional, Bergin, C., additional, Carrera, R., additional, Cooper, L., additional, Despy, L., additional, Harkett, S., additional, Mee, L., additional, Reeves, E., additional, Snelson, C., additional, Spruce, E., additional, Cooper, G., additional, Hodgson, R., additional, Pearson, D., additional, Rosbergen, M., additional, Ali, M. N., additional, Bahar, N. I., additional, Ismail, A., additional, Ismail, W. N. W., additional, Samat, N. M., additional, Piah, N. S. M., additional, Rahman, R. Abd, additional, Duroux, M., additional, Ratcliffe, M., additional, Warhurst, T., additional, Buehner, U., additional, Williams, E., additional, Jacques, N., additional, Keating, L., additional, Macgill, S., additional, Tamang, K. L., additional, Tolan, N., additional, Walden, A., additional, Bower, R., additional, Cranshaw, J., additional, Molloy, K., additional, Pitts, S., additional, Butler, J., additional, Dunlop, R., additional, Fourie, C., additional, Jarrett, P., additional, Lassig-Smith, M., additional, Livermore, A., additional, O’Donoghue, S., additional, Reade, M., additional, Starr, T., additional, Stuart, J., additional, Campbell, L., additional, Phillips, M., additional, Stephens, D., additional, Thomas, J., additional, Cooper, D., additional, McAllister, R., additional, Andrew, G., additional, Barclay, L., additional, Dawson, H., additional, Griffith, D. M., additional, Hope, D., additional, Wojcik, G., additional, McCulloch, C., additional, Paterson, R., additional, Ascough, L., additional, Paisley, C., additional, Patrick-Heselton, J., additional, Shaw, D., additional, Waugh, V., additional, Williams, K., additional, Welters, I., additional, Barge, D., additional, Jordan, A., additional, MacIsaac, C., additional, Rechnitzer, T., additional, Bass, F., additional, Gatward, J., additional, Hammond, N., additional, Janin, P., additional, Stedman, W., additional, Yarad, E., additional, Razak, N. A., additional, Dzulkipli, N., additional, Jong, S. L., additional, Asen, K., additional, Voon, W. L., additional, Liew, S., additional, Ball, J., additional, Barnes, V., additional, Dalton, C., additional, Farnell-Ward, S., additional, Farrah, H., additional, Maher, K., additional, Mellinghoff, J., additional, Ryan, C., additional, Shirley, P., additional, Conlon, L., additional, Glover, A., additional, Martin-Loeches, I., additional, O’Toole, E., additional, Ewan, J., additional, Ferrier, J., additional, Litton, E., additional, Webb, S. A., additional, Berry, W., additional, Blanco Alonso, U., additional, Bociek, A., additional, Campos, S., additional, Jawara, S., additional, Hanks, F., additional, Kelly, A., additional, Lei, K., additional, McKenzie, C., additional, Ostermann, M., additional, Wan, R., additional, Al-Soufi, S., additional, Leow, S., additional, McCann, K., additional, Reynolds, C., additional, Brickell, K., additional, Fahey, C., additional, Hays, L., additional, Hyde, N., additional, Nichol, A., additional, Ryan, D., additional, Brailsford, J., additional, Buckley, A., additional, Forbes, L., additional, Maguire, T., additional, Moore, J., additional, Murray, L., additional, Ghosh, A., additional, Park, M., additional, Said, S., additional, Visser, A., additional, Abidin, H. Z., additional, Ali, S., additional, Hassan, M. H., additional, Omar, S. C., additional, Shukeri, W. F. W., additional, Brealey, D., additional, Bercades, G., additional, Blackburn, E., additional, Macallum, N., additional, Macklin, A., additional, Ryu, J. H., additional, Tam, K., additional, Smyth, D., additional, Arif, A., additional, Bassford, C., additional, Morgan, C., additional, Swann, C., additional, Ward, G., additional, Wild, L., additional, Bone, A., additional, Elderkin, T., additional, Green, D., additional, Sach, D., additional, Salerno, T., additional, Simpson, N., additional, Brohi, F., additional, Clark, M., additional, Williams, L., additional, Brooks, J., additional, Cocks, E., additional, Cole, J., additional, Curtin, J., additional, Davies, R., additional, Hill, H., additional, Morgan, M., additional, Palmer, N., additional, Whitton, C., additional, Wise, M., additional, Baskaran, P., additional, Hasan, M. S., additional, Tham, L. Y., additional, Sol Cruz, R., additional, Dinsdale, D., additional, Edney, S., additional, Firkin, C., additional, FitzJohn, F., additional, Hill, G., additional, Hunt, A., additional, Hurford, S., additional, Jones, G., additional, Judd, H., additional, Latimer-Bell, C., additional, Lawrence, C., additional, Lesona, E., additional, Navarra, L., additional, Robertson, Y., additional, Smellie, H., additional, Vucago, A. M., additional, Young, P., additional, Clark, P., additional, Kong, J., additional, Ho, J., additional, Nayyar, V., additional, and Skelly, C., additional
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- 2023
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28. The use of handheld nasal spirometry to predict the presence of obstructive sleep apnea
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Fastenberg, Judd H., Fang, Christina H., Patel, Viraj M., Lin, Juan, and Stupak, Howard D.
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- 2018
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29. A Strategic Orientation toward Entrepreneurship: Implications for Pallet Manufacturer Performance
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Elser, Nathaniel C. and Michael, Judd H.
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Entrepreneurship ,Retail trade ,Environmental quality ,Production management ,Business ,Forest products industry - Abstract
Leaders in the wood pallet industry have faced numerous trends over the past few decades that have challenged their ability to maintain success without adopting new business models and innovations. Past literature would predict that industry managers who instill entrepreneurial processes such as innovation, risk-taking, and proactiveness into their operations should be better equipped to identify, positively react to, and take advantage of changing environmental conditions. Firms that emphasize such processes are described as being strategically orientated toward entrepreneurship. The objective of this study was to determine whether pallet manufacturing firms that exhibit entrepreneurial processes are more successful than those that do not. As an example of how an entrepreneurial orientation might influence business operations, this study also analyzed revenue-generating methods of managing wood waste. Data for the study were collected from executives of North American pallet manufacturers. Findings suggest pallet firms that continually work to improve their products and services, frequently make decisions that involve risk, and proactively seek out new opportunities have higher performance than firms that do not. Furthermore, manufacturing firms that monetize waste products exhibit greater proclivity for entrepreneurial processes than firms that pay to dispose of or give away wood waste. Results are discussed and potential implications for managers in the industry are provided., The wood pallet manufacturing industry is not often characterized as being one of rapid change and continuous innovation. It would be imprudent, however, to assume the industry has long been [...]
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- 2018
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30. Direct Puncture Onyx Embolization: An Enhanced Technique for Juvenile Nasopharyngeal Angiofibromas
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Judd H. Fastenberg, Collin Hill, Mark B. Chaskes, Amir Dehdashti, Kevin Shah, and Athos Patsalides
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- 2023
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31. Preoperative Embolization Techniques in the Treatment of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review
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Dhruv Shreedhar Kothari, Lauren A. Linker, Tristan Tham, Andrew J. Maroda, Jenessa M. McElfresh, Judd H. Fastenberg, Ralph Abi Hachem, Lucas Elijovich, Lattimore Madison Michael, and Sanjeet V. Rangarajan
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Otorhinolaryngology ,Surgery - Published
- 2023
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32. Preoperative Embolization Techniques in the Treatment of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review
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Kothari, Dhruv Shreedhar, primary, Linker, Lauren A., additional, Tham, Tristan, additional, Maroda, Andrew J., additional, McElfresh, Jenessa M., additional, Fastenberg, Judd H., additional, Hachem, Ralph Abi, additional, Elijovich, Lucas, additional, Michael, Lattimore Madison, additional, and Rangarajan, Sanjeet V., additional
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- 2023
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33. Assessing Patient-Reported Symptoms to Predict Postoperative Complications from Pituitary Surgery Using a Novel Consensus-Developed Inventory
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Ramsey, Amelia K., additional, Kothari, Dhruv S., additional, Parikh, Kara A., additional, Hachem, Ralph Abi, additional, Chan, Yvonne, additional, Choby, Garret, additional, Fastenberg, Judd H., additional, Rabinowitz, Mindy R, additional, and Rangarajan, Sanjeet V., additional
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- 2023
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- View/download PDF
34. Direct Puncture Onyx Embolization: An Enhanced Technique for Juvenile Nasopharyngeal Angiofibromas
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Fastenberg, Judd H., additional, Hill, Collin, additional, Chaskes, Mark B., additional, Dehdashti, Amir, additional, Shah, Kevin, additional, and Patsalides, Athos, additional
- Published
- 2023
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- View/download PDF
35. Preoperative Embolization Techniques in the Treatment of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review
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Kothari, Dhruv S., additional, Linker, Lauren A., additional, Tham, Tristan, additional, Maroda, Andrew J., additional, McElfresh, Jenessa M., additional, Fastenberg, Judd H., additional, Abi-Hachem, Ralph, additional, Elijovich, Lucas R., additional, Michael, L. Madison, additional, and Rangarajan, Sanjeet V., additional
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- 2023
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36. Occupational tree felling fatalities: 2010–2020
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Judd H. Michael and Serap Gorucu
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Databases, Factual ,business.industry ,Event type ,Logging ,Public Health, Environmental and Occupational Health ,Felling ,United States ,Occupational safety and health ,Trees ,Work (electrical) ,Accidents, Occupational ,Humans ,Landscaping ,Medicine ,Accidental Falls ,Occupations ,Socioeconomics ,business ,Fall prevention - Abstract
BACKGROUND Logging and landscape work are among the most hazardous occupations, and one of the most dangerous tasks in these occupations is tree felling. While much research has been conducted to examine fatalities from logging and landscape services, there is a dearth of research looking specifically at tree felling. There is a need to focus on hazards associated with tree felling activities so that proactive prevention strategies can be developed. METHODS An Occupational Safety and Health Administration (OSHA) database was used to identify occupational tree-felling fatalities in the United States during the period from 2010 through the first half of 2020. We compared data for the two industry segments of logging and landscaping services. RESULTS There were 314 fatalities over the period. The victims were overwhelmingly male with the median age being 43. Struck-by was the number one event type causing fatalities, with the head being the number one body part involved in fatalities. Falls from elevation was the only event type significantly different between the logging and landscaping industries. Poor decision-making is noted as a key component of fatal incidents, but bystanders were fatally injured due to the actions of others. CONCLUSIONS Tree felling is one of the most hazardous activities for both loggers and commercial landscapers and is a common cause of fatalities; significant differences in events and source are encountered in those two occupations. Loggers should continue efforts to adopt mechanized harvesting methods. Landscape services tree fellers should receive training related to fall prevention.
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- 2021
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37. Orbital preservation in the treatment of acute invasive fungal sinusitis
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Werner, Michael T., Powers, Luke D., and Fastenberg, Judd H.
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- 2024
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38. Nonfatal Agricultural Injuries Treated in Emergency Departments: 2015-2019
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Kelly Chege, Serap Gorucu, and Judd H. Michael
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Adult ,Male ,Adolescent ,Databases, Factual ,Fractures, Bone ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,0501 psychology and cognitive sciences ,050107 human factors ,Aged ,business.industry ,05 social sciences ,Public Health, Environmental and Occupational Health ,Emergency department ,medicine.disease ,030210 environmental & occupational health ,United States ,Hospitalization ,Cross-Sectional Studies ,Agriculture ,Wounds and Injuries ,Medical emergency ,Emergency Service, Hospital ,business - Abstract
Utilizing emergency department admissions to estimate and describe agricultural injuries in the United States (U.S.) provides a unique view of one of the country's most dangerous occupations. This study characterizes and provides nationally representative estimates of persons with non-fatal agricultural-related injuries treated in emergency departments in the U.S.We conducted a cross-sectional study using U.S. Consumer Product Safety Commission, National Electronic Injury Surveillance System (NEISS) data for patients treated in emergency departments from January 1, 2015 to December 31, 2019. We queried all cases in the NEISS database using the location code "farm" and with a narrative search using relevant key words.An estimated 62,079 people were treated in an emergency department for agricultural related injuries. The mean age estimate in this population was 39 years-old, with ages ranging from 1 to 95. Almost two-thirds of patients were male, and almost 80% were white. Approximately 30% and 22% of those injured were youth and elderly patients, respectively. The majority of injuries occurred from April through September. The most common injury was fracture, followed by open wound or amputation. There were significant differences between the body parts injured in youth versus adult patients. The primary source of injury was in the vehicles category, with tractors being the dominant vehicle type.Agricultural vehicles remain a major source of injuries that require treatment in emergency departments. Previous methods of quantifying severe ag-related injuries were limited; our research utilized NEISS data to portray injury statistics more accurately.
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- 2021
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39. Work-Family Supportiveness Organizational Perceptions: Important for the Well-Being of Male Blue-Collar Hourly Workers?
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Grandey, Alicia A., Cordeiro, Bryanne L., and Michael, Judd H.
- Abstract
The current study questions whether organizational perceptions of family supportiveness predict work-family conflict (WFC) and job satisfaction for an atypical sample of male hourly workers in a manufacturing organization, and whether those relationships depend on work (number of work hours) and family (number of family roles) demands. A unidimensional factor structure for the family supportiveness scale was not found; however a subscale for the extent that the organization supported work-family balance was strongly related to WFC and job satisfaction. An interaction was found such that those working long hours in the family-supportive work environment had lower WFC than those working long hours in an unsupportive environment, while the number of family roles (e.g., spouse, parent, eldercare) had no moderating effects. Supporting employees' non-work life is determined to be important for these employees.
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- 2007
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40. Assessment of narcotic use in management of <scp>post‐op</scp> pain after functional endoscopic sinus surgery
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Mindy Rabinowitz, Elina Toskala, Michelle Haggerty, Gurston Nyquist, Chandala Chitguppi, Kurren S. Gill, Judd H. Fastenberg, Tawfiq Khoury, and Marc Rosen
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Narcotic ,business.industry ,adult rhinology ,allergy/rhinology ,medicine.medical_treatment ,Analgesic ,lcsh:Surgery ,lcsh:RD1-811 ,General Medicine ,Functional endoscopic sinus surgery ,Evidence-based medicine ,lcsh:Otorhinolaryngology ,lcsh:RF1-547 ,Acetaminophen ,Regimen ,Allergy, Rhinology, and Immunology ,Anesthesia ,Pill ,medicine ,NARCOTIC USE ,business ,clinical practice guidelines ,Original Research ,medicine.drug - Abstract
Objectives Pain and analgesic requirements after functional endoscopic sinus surgery (FESS) vary widely. This study aims to quantify pain after routine FESS and determine the most commonly used pain management regimen. Methods Retrospective chart review of 100 patients who underwent FESS from Oct 2017 to May 2019. Patients prospectively completed a daily pain diary and reported pain levels that were categorized into no pain (0), mild (1‐3), moderate (4‐7), or severe (8‐10). Patients were categorized into narcotics, non‐narcotics, combination, or none based on type of analgesic used. Results Sixty‐nine patients were included. Majority of patients reported either mild (39%) or no pain (28%) during the first 5 PODs. Mean POD1 pain score was 3.98, which decreased with each subsequent POD. On POD1, 37% used opioids (n = 37), 32% used non‐opioids (n = 32), 22% used a combination (n = 22), and 9% used no pain meds (n = 9). Mean number of narcotic pills used within the first 5 PODs was 2 pills on any given day. Age was inversely associated with reported POD1 pain scores (P = .003) and use of preoperative steroids in patients with sinonasal polyposis was associated with lower POD1 pain scores (P = .03). Conclusions Even on POD1, majority of patients experienced either mild or no pain, and this decreases with each POD. Narcotics are grossly overprescribed and underutilized by patients postoperatively after FESS. We advocate for more judicious prescribing habits of narcotics by Otolaryngologists after FESS, and emphasize relying on non‐narcotic alternatives like Acetaminophen or NSAIDS to diminish narcotic use and abuse in the postoperative period. Level of Evidence 4.
- Published
- 2021
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41. New Protocol for Species Mix Testing in Retail Mulch Sample
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Charles D. Ray and Judd H. Michael
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Protocol (science) ,media_common.quotation_subject ,Forestry ,Competitor analysis ,Competition (biology) ,Product (business) ,Agricultural science ,General Materials Science ,Business ,Wood product ,Cypress ,Consumer welfare ,Mulch ,media_common - Abstract
Many millions of bags of mulch are sold at retail in the United States each year. Most mulch products claim to be of a certain species, with cypress being perhaps the most widely marketed. Unfortunately, it is practically impossible for the average consumer to know with certainty whether a product is indeed the species listed on the packaging. Claims of misleading behavior by some producers raise the question of whether species mix should be more closely monitored. Regulators charged with ensuring fair competition and consumer welfare, however, do not have an accurate means to determine species content. It would be difficult, if not impossible, to determine the species mix for 100% of the wood particles in a package of mulch because of the inability to identify species of the smallest particles, and the impracticality of 100% sampling in the intended use. We propose and develop a new method to allow analysts to estimate the percentage of a given species in samples of mulch, with a focus on cypress. This case study illustrates our methods and highlights the challenges in accurately determining species mix in the type of wood product. We purchased and tested 10 bags of cypress mulch obtained from six different states. Results indicate that one producer was filling some bags with only 50% cypress and others with no cypress. Consumers may therefore suffer as they receive a lower valued species, whereas honest competitors are also harmed. The wood science community could help regulators and consumers by developing a method by which small particles of wood could be positively identified as to species. Improved methods for species identification are relevant for a wide variety of purposes ranging from identifying consumer products to upholding the U.S. Lacey Act.
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- 2020
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42. Predicting prolonged length of stay after endoscopic transsphenoidal surgery for pituitary adenoma
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Marc Rosen, Judd H. Fastenberg, Erin Reilly, Gurston Nyquist, Chandala Chitguppi, James J. Evans, Mindy Rabinowitz, Swar Vimawala, Christopher J. Farrell, and Tomas Garzon-Muvdi
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Adenoma ,Adult ,Male ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Nasal Surgical Procedures ,Hypopituitarism ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Pituitary adenoma ,medicine ,Humans ,Immunology and Allergy ,Pituitary Neoplasms ,Continuous positive airway pressure ,030223 otorhinolaryngology ,Aged ,Retrospective Studies ,Transsphenoidal surgery ,Univariate analysis ,Cerebrospinal Fluid Leak ,Continuous Positive Airway Pressure ,business.industry ,Endoscopy ,Odds ratio ,Length of Stay ,Middle Aged ,medicine.disease ,Surgery ,Obstructive sleep apnea ,030228 respiratory system ,Otorhinolaryngology ,Diabetes insipidus ,Female ,business ,Diabetes Insipidus - Abstract
BACKGROUND Endoscopic transsphenoidal surgery (ETS) for the resection of pituitary adenoma has become more common throughout the past decade. Although most patients have a short postoperative hospitalization, others require a more prolonged stay. We aimed to identify predictors for prolonged hospitalization in the setting of ETS for pituitary adenomas. METHODS A retrospective chart review as performed on 658 patients undergoing ETS for pituitary adenoma at a single tertiary care academic center from 2005 to 2019. Length of stay (LoS) was defined as date of surgery to date of discharge. Patients with LoS in the top 10th percentile (prolonged LoS [PLS] >4 days, N = 72) were compared with the remainder (standard LoS [SLS], N = 586). RESULTS The average age was 54 years and 52.5% were male. The mean LoS was 2.1 days vs 7.5 days (SLS vs PLS). On univariate analysis, atrial fibrillation (p = 0.002), hypertension (p = 0.033), partial tumor resection (p < 0.001), apoplexy (p = 0.020), intraoperative cerebrospinal fluid (ioCSF) leak (p = 0.001), nasoseptal flap (p = 0.049), postoperative diabetes insipidus (DI) (p = 0.010), and readmission within 30 days (p = 0.025) were significantly associated with PLS. Preoperative continuous positive airway pressure (CPAP) (odds ratio, 15.144; 95% confidence interval, 2.596-88.346; p = 0.003) and presence of an ioCSF leak (OR, 10.362; 95% CI, 2.143-50.104; p = 0.004) remained significant on multivariable analysis. CONCLUSION For patients undergoing ETS for pituitary adenomas, an ioCSF leak or preoperative use of CPAP predicted PLS. Additional common reasons for PLS included postoperative CSF leak (10 of 72), management of DI or hypopituitarism (15 of 72), or reoperation due to surgical or medical complications (14 of 72).
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- 2020
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43. Employee Alignment with Strategic Change: A Study of Strategy-supportive Behavior among Blue-collar Employees
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Gagnon, Mark A., Jansen, Karen J., and Michael, Judd H.
- Published
- 2008
44. Demographic Antecedents and Performance Consequences of Structural Holes in Work Teams
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Balkundi, Prasad, Kilduff, Martin, Barsness, Zoe I., and Michael, Judd H.
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- 2007
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45. A Voxel-Based Individual Tree Stem Detection Method Using Airborne LiDAR in Mature Northeastern U.S. Forests
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Hershey, Jeff L., primary, McDill, Marc E., additional, Miller, Douglas A., additional, Holderman, Brennan, additional, and Michael, Judd H., additional
- Published
- 2022
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46. The Impact of the Pandemic on Otolaryngology Patients With Negative COVID‐19 Status: Commentary and Insights From Orbital Emergencies
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Rand Rodgers, Ahmed Sheikh, William A. Kennedy, Judd H. Fastenberg, Danielle Bottalico, and Michael Setzen
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Adult ,Male ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Graves' eye disease ,Pneumonia, Viral ,MEDLINE ,Health Services Accessibility ,Betacoronavirus ,Otolaryngology ,03 medical and health sciences ,0302 clinical medicine ,Pandemic ,Orbital Diseases ,Practice Management, Medical ,medicine ,Humans ,Practice Patterns, Physicians' ,Clinical care ,030223 otorhinolaryngology ,Intensive care medicine ,Pandemics ,Personal Protective Equipment ,Aged ,SARS-CoV-2 ,business.industry ,COVID-19 ,Middle Aged ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Female ,Surgery ,Emergencies ,Coronavirus Infections ,business - Abstract
Efforts aimed at minimizing the spread of COVID-19 and "flattening the curve" may be affecting clinical care delivery for non-COVID-19 cases that include otolaryngologic and orbital conditions. We are witnessing changes in the manner that patients present, as well as modifications in clinical management strategies. An improved understanding of these phenomena and the contributing factors is essential for otolaryngologists to provide sound clinical care during this unprecedented pandemic.
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- 2020
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47. Treatment‐related morbidity in patients treated for sinonasal malignancy
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James J. Evans, Gregory Epps, Marc Rosen, Chandala Chitguppi, Swar Vimawala, Jena Patel, Judd H. Fastenberg, Mindy Rabinowitz, and Gurston Nyquist
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medicine.medical_specialty ,Sinonasal malignancy ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,medicine ,Humans ,Immunology and Allergy ,Sinusitis ,030223 otorhinolaryngology ,Retrospective Studies ,business.industry ,Chronic sinusitis ,Multimodal therapy ,Functional endoscopic sinus surgery ,Middle Aged ,Surgery ,Exact test ,030228 respiratory system ,Otorhinolaryngology ,Paranasal Sinus Diseases ,Toxicity ,Quality of Life ,Morbidity ,business ,Paranasal Sinus Neoplasms - Abstract
Background Sinonasal malignancies are a rare, heterogeneous group of tumors that often present at an advanced stage and require multimodal therapy. The presence of high-grade toxicity and sinonasal complications after treatment can negatively impact quality of life. In this study we aim to describe posttreatment morbidity in patients with sinonasal malignancy. Methods A retrospective analysis of all patients treated for sinonasal malignancy was conducted from 2005 to 2018 at a tertiary referral institution. A total of 129 patients met the inclusion criteria. Primary outcomes were treatment details, pathology, posttreatment complications, and radiation toxicity. Fisher's exact test, chi-square test, and Student t test were used for statistical analysis. Results Mean age was 58.4 (median, 61; range, 19-94) years. After diagnosis, 24 patients had surgery alone, 46 had surgery with radiation alone, 47 had surgery with chemoradiation, and 14 received definitive chemoradiation. Overall, 10.4% (n = 12) of patients had postoperative complications, and 21.0% (n = 22) had high-grade (grade 3-5) radiation toxicity. After radiation, 20% (n = 21) of patients had chronic sinusitis requiring functional endoscopic sinus surgery and 20% (n = 21) had symptomatic nasal obstruction requiring operative debridement. Conclusion Sinonasal complications, including nasal obstruction and chronic sinusitis, occur frequently after definitive treatment of sinonasal malignancy and should be addressed when considering quality of life in survivors. These complications occur more frequently in patients who undergo chemoradiation as opposed to surgery alone.
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- 2020
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48. A Simple Onlay Sellar Reconstruction Does Not Increase the Risk of Postoperative Cerebrospinal Fluid Leak in Well-Selected Patients
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Judd H. Fastenberg, Marc Rosen, Mark B. Chaskes, Mindy Rabinowitz, James J. Evans, Tomas Garzon-Muvdi, Swar Vimawala, Chandala Chitguppi, Gurston F. Nyquist, and Meagan Falls
- Subjects
Transsphenoidal surgery ,medicine.medical_specialty ,Leak ,business.industry ,medicine.medical_treatment ,Oxidized cellulose ,medicine.disease ,Surgery ,Diaphragm (structural system) ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Cerebrospinal fluid ,chemistry ,Postoperative cerebrospinal fluid leak ,Pituitary adenoma ,030220 oncology & carcinogenesis ,medicine ,Neurology (clinical) ,Neurosurgery ,business ,030217 neurology & neurosurgery - Abstract
Objective A variety of endonasal sellar repair techniques have been described; many of which are complex, expensive, and carry potential morbidity but are felt to be necessary to prevent postoperative cerebrospinal fluid (CSF) leaks. We propose an effective, technically simple repair for select sellar defects utilizing an onlay of regenerated oxidized cellulose. Design Retrospective review of patients from a single neurosurgeon who underwent endoscopic transsphenoidal surgery for pituitary adenoma and sellar reconstruction with only an onlay of regenerated oxidized cellulose. Patients were selected for this repair technique based on the absence of: (1) intraoperative identification of a CSF leak, (2) patulous diaphragm (expanded diaphragm sella herniating to or through sellar floor defect), and (3) other prohibiting comorbidities. Setting The present study was conducted at a tertiary care center. Participants In this study, pituitary adenoma patients were the participants. Outcome Measures Main outcome measure of the study is postoperative CSF leak. Results A total of 172 patients were identified. Of these, 153 were initial resections of pituitary adenomas. Gross total resection was achieved in 142 (82.6%) cases. Average tumor size was 2.2 ± 1.1 cm. Average tumor volume was 10.4 ± 19.8 cm3. No patients had intraoperative CSF leaks. All cases were repaired with only an onlay of regenerated oxidized cellulose. There were two postoperative CSF leaks (1.16%). Pre and postoperative SNOT-22 scores were 12.9 ± 11.9 and 14.3 ± 14.9 (p = 0.796), respectively. Conclusion The use of an onlay of regenerated oxidized cellulose alone is an effective repair technique for select sellar defects. This technique does not result in increased postoperative CSF leak rates and avoids the higher relative cost and potential morbidity associated with more complex, multilayered closures.
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- 2020
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49. Loss of SMARCB1 Expression Confers Poor Prognosis to Sinonasal Undifferentiated Carcinoma
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James Evans, Gurston Nyquist, Jennifer Johnson, Judd H. Fastenberg, Stacey K. Mardekian, Chandala Chitguppi, Ethan Berman, Marc Rosen, Mindy Rabinowitz, Voichita Bar-Ad, and Jeremy Molligan
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Oncology ,0303 health sciences ,Poor prognosis ,medicine.medical_specialty ,business.industry ,Tumor biology ,Cancer ,Sinonasal Tract ,medicine.disease ,Tertiary care ,03 medical and health sciences ,Sinonasal undifferentiated carcinoma ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,Immunohistochemistry ,Neurology (clinical) ,SMARCB1 ,business ,030304 developmental biology - Abstract
Background Due to the diverse histopathologic features and variable survival rates seen in sinonasal undifferentiated carcinoma (SNUC), it is likely that this diagnostic entity is comprised of a heterogonous group of morphologically undifferentiated tumors. As advancements in molecular testing have led to a better understanding of tumor biology, it has become increasingly evident that SNUC may actually encompass several tumor subtypes with different clinical behavior. As a result, it is also likely that all SNUC patients cannot be treated in the same fashion. Recent investigations have identified loss of the tumor suppressor SMARCB1 (INI1) expression in a subset of undifferentiated sinonasal tumors and extrasinonasal tumors and, studies have suggested that this genetic aberration may be a poor prognostic marker. The objective of this study was to identify differential expression of SMARCB1 in SNUC and to analyze and compare the survival outcomes in SNUC patients with and without SMARCB1 expression. Methods All cases of undifferentiated or poorly differentiated neoplasms of the sinonasal tract treated between 2007 and 2018 at a single tertiary care institution were selected. All cases of SNUC were tested for SMARCB1 status by immunohistochemistry (IHC). Clinical parameters were analyzed using Student's t-test and Fischer's test. Kaplan–Meier methods were used to estimate survival durations, while comparison between both the subgroups was done using the log-rank test. Statistical analysis was performed with the use of SPSS software, Version 25 (IBM, New York, NY, United States). Results Fourteen cases of SNUC were identified. Approximately two-thirds (64%; n = 9) of patients were male and the majority (79%; n = 11) were between fifth to seventh decade. Skull base and orbital invasion were seen in 79% (n = 11) and 93% (n = 13) of cases, respectively. Fifty-seven percent of tumors (n = 8) retained SMARCB1 expression by IHC (SR-SNUC), while the remaining 43% (n = 6) showed loss of SMARCB1 expression and, thus, were considered as SMARCB1-deficient (SD-SNUC). Although clinicopathological features and treatment modalities were similar, SD-SNUC showed poorer (OS: p = 0.07; disease free survival [DFS]: p = 0.02) overall survival (OS) and DFS on Kaplan–Meier curves. Additionally, SD-SNUC showed higher recurrence (75 vs. 17%) and mortality (67 vs. 14%) (hazard rate = 8.562; p = 0.05) rates. Both OS (28.82 ± 31.15 vs. 53.24 ± 37.50) and DFS durations (10.62 ± 10.26 vs. 43.79 ± 40.97) were consistently worse for SD-SNUC. Five-year survival probabilities were lower for SD-SNUC (0.33 vs. 0.85). Conclusion SNUC represents a heterogeneous group of undifferentiated sinonasal malignancies. Based on the status of SMARCB1 expression, the two subgroups SD-SNUC and SR-SNUC appear to represent distinct clinical entities, with loss of SMARCB1 expression conferring an overall worse prognosis.
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- 2019
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50. Anterior Skull Base Tumors and Surgery
- Author
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Gurston Nyquist, Judd H. Fastenberg, and Blair Barton
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medicine.medical_specialty ,business.industry ,medicine ,business ,Surgery ,Anterior skull base - Abstract
Anterior skull base surgery requires intimate knowledge of a highly complex anatomic region containing critical neurovascular structures. A wide array of pathologies can occur along the anterior cranial base, including meningiomas, esthesioneuroblastomas, pituitary adenomas, craniopharyngiomas, chondrosarcomas, and chordomas. Advancements in endoscopic sinus surgery have allowed many of these tumors to be effectively treated via an endoscopic endonasal technique. This approach obviates the need for large incisions causing cosmetic deformity, improves magnification of the surgical field, and offers a direct path to lesions thus avoiding retraction of structures such as the brain and nerves. Surgeons must understand the limitations of endoscopic techniques and consider open or combined open and endoscopic approaches when appropriate. Reconstructive anterior skull base techniques vary depending on the size and location of defects, along with factors such as intracranial pressure and patient co-morbidities. Large skull base defects require multilayer reconstruction that include a watertight primary dural repair with either synthetic or autologous tissue, followed by local vascularized tissue flaps. This review contains 8 figures, 2 videos, 4 tables and 33 references Key words: Anterior skull base, meningioma, esthesioneuroblastoma, chordoma, pituitary, CSF leak, nasosptal flap, dural repair, expanded endonasal approaches, endoscopic surgery
- Published
- 2021
- Full Text
- View/download PDF
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