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1. Associations of empirically derived dietary patterns and cognitive performance in older men: Results of the Osteoporotic Fractures in Men (MrOS) study

Author

Rogers-Soeder, Tara S, Patel, Sheena, Shikany, James M, Langsetmo, Lisa, Judd, Suzanne E, Ensrud, Kristine E, LeBlanc, Erin, Cauley, Jane A, Redline, Susan, Fink, Howard A, Lane, Nancy E, and Group, Osteoporotic Fractures in Men Study Research

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Nutrition, Brain Disorders, Behavioral and Social Science, Aging, Dietary Supplements, Prevention, Osteoporotic Fractures in Men (MrOS) Study Research Group, Cognition, Dementia, Dietary pattern, Factor analysis, Older men, Clinical Sciences, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveThe aim of this study was to examine associations between empirically derived dietary pattern scores and cognition, as well as risk of cognitive decline, over an average of 4.6 (± 0.3) years in older men.Materials and methodsThis analysis was conducted as part of the Osteoporotic Fractures in Men (MrOS) prospective cohort study. Diet was assessed at Visit 1 (3/2000-4/2002) by food frequency questionnaire, and dietary patterns (Western and Prudent) were derived by factor analysis. The analytic cohort comprised 4231 community-dwelling American men who were aged 65 years or more. Cognitive function was assessed with the Modified Mini-Mental State exam (3MS) and the Trails B test at Visit 1 and at Visit 2 (3/2005-5/2006). Associations between dietary pattern score and cognition and risk of cognitive decline were estimated using mixed effects regression models. Model 1 was adjusted for age, clinic site and total energy intake (TEI). Model 2 was further adjusted for calcium and vitamin D supplement use, body mass index (BMI), physical activity, smoking, diabetes and hypertension (Western diet group) and education, calcium and vitamin D supplement use, depression, BMI, physical activity, smoking and stroke (Prudent diet group).ResultsAdherence to the Western dietary pattern was associated with higher 3MS scores and shorter Trails B test time at Visit 1 in Model 2. Adherence to the Prudent dietary pattern was associated with higher 3MS scores in Model 1 but not Model 2. There were no independent associations between dietary pattern scores and risk of cognitive decline 4.6 (± 0.3) years later at Visit 2.ConclusionThe results do not support a robust protective effect of the Prudent dietary pattern on cognition in the MrOS cohort. Associations between the Western dietary pattern and better cognitive scores should be interpreted with caution. Further research is needed to understand the complex interactions between dietary patterns and cognition in older men.

Published
2024

5. Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

Author

Gupta, Yask, Friedman, David J., McNulty, Michelle T., Khan, Atlas, Lane, Brandon, Wang, Chen, Ke, Juntao, Jin, Gina, Wooden, Benjamin, Knob, Andrea L., Lim, Tze Y., Appel, Gerald B., Huggins, Kinsie, Liu, Lili, Mitrotti, Adele, Stangl, Megan C., Bomback, Andrew, Westland, Rik, Bodria, Monica, Marasa, Maddalena, Shang, Ning, Cohen, David J., Crew, Russell J., Morello, William, Canetta, Pietro, Radhakrishnan, Jai, Martino, Jeremiah, Liu, Qingxue, Chung, Wendy K., Espinoza, Angelica, Luo, Yuan, Wei, Wei-Qi, Feng, Qiping, Weng, Chunhua, Fang, Yilu, Kullo, Iftikhar J., Naderian, Mohammadreza, Limdi, Nita, Irvin, Marguerite R., Tiwari, Hemant, Mohan, Sumit, Rao, Maya, Dube, Geoffrey K., Chaudhary, Ninad S., Gutiérrez, Orlando M., Judd, Suzanne E., Cushman, Mary, Lange, Leslie A., Lange, Ethan M., Bivona, Daniel L., Verbitsky, Miguel, Winkler, Cheryl A., Kopp, Jeffrey B., Santoriello, Dominick, Batal, Ibrahim, Pinheiro, Sérgio Veloso Brant, Oliveira, Eduardo Araújo, Simoes e Silva, Ana Cristina, Pisani, Isabella, Fiaccadori, Enrico, Lin, Fangming, Gesualdo, Loreto, Amoroso, Antonio, Ghiggeri, Gian Marco, D’Agati, Vivette D., Magistroni, Riccardo, Kenny, Eimear E., Loos, Ruth J. F., Montini, Giovanni, Hildebrandt, Friedhelm, Paul, Dirk S., Petrovski, Slavé, Goldstein, David B., Kretzler, Matthias, Gbadegesin, Rasheed, Gharavi, Ali G., Kiryluk, Krzysztof, Sampson, Matthew G., Pollak, Martin R., and Sanna-Cherchi, Simone

Published
2023
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7. Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design

Author

Oelsner, Elizabeth C, Krishnaswamy, Akshaya, Balte, Pallavi P, Allen, Norrina Bai, Ali, Tauqeer, Anugu, Pramod, Andrews, Howard F, Arora, Komal, Asaro, Alyssa, Barr, R Graham, Bertoni, Alain G, Bon, Jessica, Boyle, Rebekah, Chang, Arunee A, Chen, Grace, Coady, Sean, Cole, Shelley A, Coresh, Josef, Cornell, Elaine, Correa, Adolfo, Couper, David, Cushman, Mary, Demmer, Ryan T, Elkind, Mitchell SV, Folsom, Aaron R, Fretts, Amanda M, Gabriel, Kelley P, Gallo, Linda C, Gutierrez, Jose, Han, Mei Lan K, Henderson, Joel M, Howard, Virginia J, Isasi, Carmen R, Jacobs, David R, Judd, Suzanne E, Mukaz, Debora Kamin, Kanaya, Alka M, Kandula, Namratha R, Kaplan, Robert C, Kinney, Gregory L, Kucharska-Newton, Anna, Lee, Joyce S, Lewis, Cora E, Levine, Deborah A, Levitan, Emily B, Levy, Bruce D, Make, Barry J, Malloy, Kimberly, Manly, Jennifer J, Mendoza-Puccini, Carolina, Meyer, Katie A, Min, Yuan-I Nancy, Moll, Matthew R, Moore, Wendy C, Mauger, David, Ortega, Victor E, Palta, Priya, Parker, Monica M, Phipatanakul, Wanda, Post, Wendy S, Postow, Lisa, Psaty, Bruce M, Regan, Elizabeth A, Ring, Kimberly, Roger, Véronique L, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Schembri, Michael, Schwartz, David A, Seshadri, Sudha, Shikany, James M, Sims, Mario, Stukovsky, Karen D Hinckley, Talavera, Gregory A, Tracy, Russell P, Umans, Jason G, Vasan, Ramachandran S, Watson, Karol E, Wenzel, Sally E, Winters, Karen, Woodruff, Prescott G, Xanthakis, Vanessa, Zhang, Ying, Zhang, Yiyi, and Investigators, for the C4R

Subjects
Public Health, Health Sciences, Social Determinants of Health, Basic Behavioral and Social Science, Coronaviruses Disparities and At-Risk Populations, Prevention, Coronaviruses, Infectious Diseases, Clinical Research, Emerging Infectious Diseases, Behavioral and Social Science, Aetiology, 2.4 Surveillance and distribution, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, COVID-19, Cohort Studies, Humans, Middle Aged, Pandemics, Prospective Studies, SARS-CoV-2, United States, Young Adult, cohort studies, coronavirus disease 2019, severe acute respiratory syndrome coronavirus 2, %22">>, C4R Investigators, severe acute respiratory syndrome coronavirus 2, Mathematical Sciences, Medical and Health Sciences, Epidemiology
Abstract

The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study of adults comprising 14 established US prospective cohort studies. Starting as early as 1971, investigators in the C4R cohort studies have collected data on clinical and subclinical diseases and their risk factors, including behavior, cognition, biomarkers, and social determinants of health. C4R links this pre-coronavirus disease 2019 (COVID-19) phenotyping to information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute and postacute COVID-related illness. C4R is largely population-based, has an age range of 18-108 years, and reflects the racial, ethnic, socioeconomic, and geographic diversity of the United States. C4R ascertains SARS-CoV-2 infection and COVID-19 illness using standardized questionnaires, ascertainment of COVID-related hospitalizations and deaths, and a SARS-CoV-2 serosurvey conducted via dried blood spots. Master protocols leverage existing robust retention rates for telephone and in-person examinations and high-quality event surveillance. Extensive prepandemic data minimize referral, survival, and recall bias. Data are harmonized with research-quality phenotyping unmatched by clinical and survey-based studies; these data will be pooled and shared widely to expedite collaboration and scientific findings. This resource will allow evaluation of risk and resilience factors for COVID-19 severity and outcomes, including postacute sequelae, and assessment of the social and behavioral impact of the pandemic on long-term health trajectories.

Published
2022

11. Closing the Last Mile Gap in Access to Multimodality Imaging in Rural Settings: Design of the Imaging Core of the Risk Underlying Rural Areas Longitudinal Study

Author

Fazlalizadeh, Hooman, Khan, Muhammad Shahzeb, Fox, Ervin R., Douglas, Pamela S., Adams, David, Blaha, Michael J., Daubert, Melissa A., Dunn, Gary, van den Heuvel, Edwin, Kelsey, Michelle D., Martin, Randolph P., Thomas, James D., Thomas, Yngvil, Judd, Suzanne E., Vasan, Ramachandran S., Budoff, Matthew J., and Bloomfield, Gerald S.

Published
2024
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17. Age and sex differences in the association between neighborhood socioeconomic environment and incident diabetes: Results from the diabetes location, environmental attributes and disparities (LEAD) network

Author

Uddin, Jalal, Zhu, Sha, Adhikari, Samrachana, Nordberg, Cara M., Howell, Carrie R., Malla, Gargya, Judd, Suzanne E., Cherrington, Andrea L., Rummo, Pasquale E., Lopez, Priscilla, Kanchi, Rania, Siegel, Karen, De Silva, Shanika A., Algur, Yasemin, Lovasi, Gina S., Lee, Nora L., Carson, April P., Hirsch, Annemarie G., Thorpe, Lorna E., and Long, D. Leann

Published
2023
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22. APOL1 Nephropathy Risk Alleles and Mortality in African American Adults: A Cohort Study

Author

Gutiérrez, Orlando M, Irvin, Marguerite R, Zakai, Neil A, Naik, Rakhi P, Chaudhary, Ninad S, Estrella, Michelle M, Limou, Sophie, Judd, Suzanne E, Cushman, Mary, Kopp, Jeffrey B, and Winkler, Cheryl A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Genetics, Clinical Research, Prevention, Renal and urogenital, Good Health and Well Being, Black or African American, Aged, Alleles, Apolipoprotein L1, Cause of Death, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Mortality, Proportional Hazards Models, Renal Insufficiency, Chronic, APOL1 genotype, African American, CKD progression, chronic kidney disease, genetic differences, genetic risk factor, mortality, nephropathy, racial/ethnic disparities, risk allele, survival, Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Rationale & objectiveAPOL1 nephropathy risk alleles are associated with the development of chronic kidney disease (CKD) in African Americans. Although CKD is an established risk factor for mortality, associations of APOL1 risk alleles with mortality are uncertain.Study designProspective cohort.Settings & participants10,380 African American and 17,485 white American participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.ExposuresAPOL1 nephropathy risk alleles.OutcomesAll-cause and cause-specific mortality.Analytical approachCox proportional hazards models were used to examine the association of APOL1 high-risk genotypes (2 risk alleles) versus APOL1 low-risk genotypes (0/1 risk allele) with all-cause and cause-specific mortality in African Americans and examine the risk for all-cause mortality in African Americans with high-risk genotypes versus African Americans with low-risk genotypes and white Americans.ResultsAPOL1 high-risk participants were younger and had a higher prevalence of albuminuria than low-risk participants. There was no statistically significant association of APOL1 high- versus low-risk genotypes with all-cause mortality in models adjusted for sociodemographic variables, comorbid conditions, and kidney function (HR, 0.88; 95% CI, 0.77-1.01). After further adjustment for genetic ancestry in a subset with available data, a statistically significant association emerged (HR, 0.81; 95% CI, 0.69-0.96). Associations differed by CKD status (Pinteraction=0.04), with African Americans with high-risk genotypes having lower risk for mortality than those with low-risk genotypes in fully adjusted models (HR, 0.78; 95% CI, 0.62-0.99) among those with CKD, but not those without CKD (HR, 0.84; 95% CI, 0.66-1.05). Compared with white Americans, African Americans with high-risk genotypes had a similar rate of mortality, whereas African Americans with low-risk genotypes had a higher rate of mortality (HR, 1.07; 95% CI, 1.00-1.14) in fully adjusted models.LimitationsLack of follow-up measures of kidney function.ConclusionsAfrican Americans with high-risk APOL1 genotypes had lower mortality than those with low-risk genotypes in multivariable-adjusted models including genetic ancestry.

Published
2020

23. Chronic Kidney Disease Awareness and Longitudinal Health Outcomes: Results from the REasons for Geographic And Racial Differences in Stroke Study

Author

Tummalapalli, Sri Lekha, Vittinghoff, Eric, Crews, Deidra C, Cushman, Mary, Gutiérrez, Orlando M, Judd, Suzanne E, Kramer, Holly J, Peralta, Carmen A, Tuot, Delphine S, Shlipak, Michael G, and Estrella, Michelle M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Prevention, Cardiovascular, Stroke, Renal and urogenital, Good Health and Well Being, Aged, Aged, 80 and over, Albuminuria, Coronary Disease, Disease Progression, Female, Follow-Up Studies, Geography, Glomerular Filtration Rate, Health Knowledge, Attitudes, Practice, Health Status Disparities, Humans, Longitudinal Studies, Male, Middle Aged, Race Factors, Renal Insufficiency, Chronic, Risk Factors, Severity of Illness Index, United States, Chronic kidney disease, Awareness, Patient education, Urology & Nephrology, Clinical sciences
Abstract

BackgroundThe majority of people with chronic kidney disease (CKD) are unaware of their kidney disease. Assessing the clinical significance of increasing CKD awareness has critical public health and healthcare delivery implications. Whether CKD awareness among persons with CKD is associated with longitudinal health behaviors, disease management, and health outcomes is unknown.MethodsWe analyzed data from participants with CKD in the REasons for Geographic And Racial Differences in Stroke study, a national, longitudinal, population-based cohort. Our predictor was participant CKD awareness. Outcomes were (1) health behaviors (smoking avoidance, exercise, and nonsteroidal anti-inflammatory drug use); (2) CKD management indicators (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use, statin use, systolic blood pressure, fasting blood glucose, and body mass index); (3) change in estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR); and (4) health outcomes (incident end-stage kidney disease [ESKD], coronary heart disease [CHD], stroke, and death). Logistic and linear regressions were used to examine the association of baseline CKD awareness with outcomes of interest, adjusted for CKD stage and participant demographic and clinical factors.ResultsOf 6,529 participants with baseline CKD, 285 (4.4%) were aware of their CKD. Among the 3,586 participants who survived until follow-up (median 9.5 years), baseline awareness was not associated with subsequent odds of health behaviors, CKD management indicators, or changes in eGFR and UACR in adjusted analyses. Baseline CKD awareness was associated with increased risk of ESKD (adjusted hazard ratio [aHR] 1.44; 95% CI 1.08-1.92) and death (aHR 1.18; 95% CI 1.00-1.39), but not with subsequent CHD or stroke, in adjusted models.ConclusionsIndividuals aware of their CKD were more likely to experience ESKD and death, suggesting that CKD awareness reflects disease severity. Most persons with CKD, including those that are high-risk, remain unaware of their CKD. There was no evidence of associations between baseline CKD awareness and longitudinal health behaviors, CKD management indicators, or eGFR decline and albuminuria.

Published
2020

33. Differences in Risk of Sudden Cardiac Death Between Blacks and Whites

Author

Deo, Rajat, Safford, Monika M, Khodneva, Yulia A, Jannat-Khah, Deanna P, Brown, Todd M, Judd, Suzanne E, McClellan, William M, Rhodes, J David, Shlipak, Michael G, Soliman, Elsayed Z, and Albert, Christine M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Clinical Research, Heart Disease, Prevention, 2.4 Surveillance and distribution, Aetiology, Good Health and Well Being, Aged, Alcohol Drinking, Arrhythmias, Cardiac, Black People, Cohort Studies, Death, Sudden, Cardiac, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Smoking, United States, White People, epidemiology, population science, race, risk factor, risk stratification, sudden cardiac death, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundPrior studies have consistently demonstrated that blacks have an approximate 2-fold higher incidence of sudden cardiac death (SCD) than whites; however, these analyses have lacked individual-level sociodemographic, medical comorbidity, and behavioral health data.ObjectivesThe purpose of this study was to evaluate whether racial differences in SCD incidence are attributable to differences in the prevalence of risk factors or rather to underlying susceptibility to fatal arrhythmias.MethodsThe Reasons for Geographic and Racial Differences in Stroke study is a prospective, population-based cohort of adults from across the United States. Associations between race and SCD defined per National Heart, Lung, and Blood Institute criteria were assessed.ResultsAmong 22,507 participants (9,416 blacks and 13,091 whites) without a history of clinical cardiovascular disease, there were 174 SCD events (67 whites and 107 blacks) over a median follow-up of 6.1 years (interquartile range: 4.6 to 7.3 years). The age-adjusted SCD incidence rate (per 1,000 person-years) was higher in blacks (1.8; 95% confidence interval [CI]: 1.4 to 2.2) compared with whites (0.7; 95% CI: 0.6 to 0.9), with an unadjusted hazard ratio of 2.35; 95% CI: 1.74 to 3.20. The association of black race with SCD risk remained significant after adjustment for sociodemographics, comorbidities, behavioral measures of health, intervening cardiovascular events, and competing risks of non-SCD mortality (hazard ratio: 1.97; 95% CI: 1.39 to 2.77).ConclusionsIn a large biracial population of adults without a history of cardiovascular disease, SCD rates were significantly higher in blacks as compared with whites. These racial differences were not fully explained by demographics, adverse socioeconomic measures, cardiovascular risk factors, and behavioral measures of health.

Published
2018

37. Abstract 14515: Initial Experience With Artificial Intelligence-Guided Echocardiography Acquisition in Rural America: Implementation and Quality Assessment

Author

Kelsey, Michelle, Dunn, Gary, Duckworth, muchelle, Provencher, Alicia, Pattison, Brenda, Adams, David, Blaha, Michael J, Budoff, Matthew J, Cheng, Susan, Fox, Ervin R, Judd, Suzanne E, Martin, Randolph, Ramachandran, Vasan S, Rhodes, James D, Kloster Thomas, Yngvil, Thomas, James, Daubert, Melissa A, Douglas, Pamela S, and Bloomfield, Gerald S

Published
2022
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44. Risk Prediction of Dementia in Middle‐aged and Older Adults: The Dementia Risk Prediction Pooling (DRPP) Consortium

Author

Allen, Norrina, primary, Krefman, Amy, additional, Stephan, John, additional, Yu, Jingzhi, additional, Carolan, Padraig, additional, Sedaghat, Sanaz, additional, Mansolf, Maxwell, additional, Soumare, Aicha, additional, Gross, Alden L., additional, Aiello, Allison, additional, Singh‐Manoux, Archana, additional, Ikram, M. Arfan, additional, Helmer, Catherine, additional, Tzourio, Christophe, additional, Satizabal, Claudia L., additional, Levine, Deborah A, additional, Lloyd‐Jones, Donald, additional, Briceno, Emily M, additional, Sorond, Farzaneh, additional, Wolters, Frank J., additional, Himali, Jayandra Jung, additional, Launer, Lenore J J., additional, Zhao, Lihui, additional, Lopez, Oscar L., additional, Debette, Stéphanie, additional, Seshadri, Sudha, additional, Judd, Suzanne E, additional, Hughes, Tim M., additional, Gudnason, Vilmundur, additional, and Scholtens, Denise, additional

Published
2023
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45. Accordance to a MIND–Style Diet is Associated with Decreased Risk of Dementia Mortality in the REasons for Geographic and Racial Disparities in Stroke (REGARDS) Cohort

Author

Judd, Suzanne E, primary, Howard, George, additional, Tangney, Christy C, additional, Pearson, Keith, additional, Shikany, James M, additional, Cushman, Mary, additional, Wilson, Nicole, additional, Howard, Virginia J, additional, Sawyer, Russell, additional, Oladele, Carol, additional, and Manly, Jennifer J., additional

Published
2023
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46. Prediction of Dementia Using Machine Learning Methods within a Large Pooled Consortia: The Dementia Risk Prediction Pooling (DRPP) Consortium

Author

Yu, Jingzhi, primary, Stephan, John, additional, Krefman, Amy, additional, Carolan, Padraig, additional, Sedaghat, Sanaz, additional, Mansolf, Maxwell, additional, Soumare, Aicha, additional, Gross, Alden L., additional, Aiello, Allison, additional, Singh‐Manoux, Archana, additional, Ikram, M. Arfan, additional, Helmer, Catherine, additional, Tzourio, Christophe, additional, Satizabal, Claudia L., additional, Levine, Deborah A, additional, Lloyd‐Jones, Donald, additional, Briceno, Emily M, additional, Sorond, Farzaneh, additional, Wolters, Frank J., additional, Himali, Jayandra Jung, additional, Launer, Lenore J J., additional, Zhao, Lihui, additional, Lopez, Oscar L., additional, Seshadri, Sudha, additional, Debette, Stéphanie, additional, Judd, Suzanne E, additional, Hughes, Tim M., additional, Gudnason, Vilmundur, additional, Scholtens, Denise, additional, and Allen, Norrina, additional

Published
2023
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47. Abstract 11396: Circulating Biomarkers Improve ChA 2 DS 2 -VASC Risk Prediction in Atrial Fibrillation: The CHA 2 DS 2 -VASc-Biomarkers Model

Author

Short, Samuel, primary, Hald, Erin, additional, Wilkinson, Katherine, additional, Howard, George, additional, Howard, Virginia J, additional, Judd, Suzanne E, additional, Soliman, Elsayed Z, additional, Kissela, Brett M, additional, Robinson, David, additional, Stanton, Robert J, additional, and Cushman, Mary, additional

Published
2023
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