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Background: 1,3,4-thiadiazole nucleus is a flexible nucleus. There are numerous biological activities showed by this nucleus. Anticancer, anthelmintic, antimicrobial, anti-inflammatory, antioxidant; anti-HIV, anti- tubercular and anti-carbonic anhydrase are a few activities showed by 1,3,4-thiadiazole derivatives. This project study aimed to investigate the anthelmintic and in silico anticancer activity of derivatives of 1,3,4-thiadiazole. Materials and Methods: The UV visible spectrophotometer (Shimadzu UV-1900) has been used to determine λmax of the synthesized molecules. The FT-IR (Bruker Alpha-II) spectrometer was used for IR spectra (4000-400 cm-1) via the KBr disc method. Proton (1H) and Carbon-13 (13C) NMR spectra were recorded in CDCl3 or (D6) DMSO at 300-500 MHz and 101-125 MHz, respectively, using the Bruker AV-III 400 spectrometer (Germany). High-Resolution Mass Spectra (HRMS) were obtained using the Xevo G2-XS QT of Mass Spectrometer (USA) with positive ESI mode at 70 eV. Results: The bonding energy for compounds 1, 2 and 3 were all in the range -42.929 to -48.909 kcal/mol. Results of the docking study shows interactions of compound 3 with the neighboring residues and showing significant anticancer activity. The presence of o-nitro, m-nitro and p-hydroxy groups makes compounds 1 (105.77%), 2 (131.67%) and 3 (155.54%) more potent and nearly equal in terms of inhibition percentage when compared to standard ascorbic acid. Compound-1 [5-([1,1'-biphenyl]-4-yl)- N -(2-nitrobenzylidene)- 1,3,4-thiadiazol-2-amine] showed significant anthelmintic activity. Conclusion: The biological profiles of these new generations of thiadiazoles would represent a fruitful matrix for further development of better medicinal agents. [ABSTRACT FROM AUTHOR]

Introduction-Medicinal plants contain numerous biologically active compounds and over the years, medicinal plants have been found useful in the treatment and management of various health problems. Basella rubra L. (Basellaceae), commonly called as Indian or Malabar spinach is found in tropical and sub-tropical areas and is commonly consumed green leafy vegetable as well as used as a traditional medicine. The combination of nutritional and pharmacological substances known as nutraceuticals makes them a type of medicine. Methods- All English-language works published before 2022 were searched in the literature. Electronic databases like Pub Med, Embase, Web of Science, Google Scholar, and Cochrane Library were used in the search. Results-The presence of a diversified set of pharmacologically bioactive chemicals from a variety of classes, including alkaloid, carbohydrates, reducing sugar, protein, saponin, starch, tannin, phenol, glycosides, sterols, terpenoids, flavonoids, volatile oils, anthraquinones and mucilage are thought to be the cause of Basella rubra's broad range of biological activities such as anti-inflammatory, anticancer, antiviral, anti-cholesterol, anti-ulcer, antimicrobial, wound healing activities. Basella rubra is a good source of calcium, iron, and vitamins A and C. Seed contains fatty oils such as palmitic, oleic and linolenic acid. Conclusion- Basella plant species contain several phytoconstituents like betacyanin, carotenoids, bioflavonoids, β-sitosterol and lupeol which are reported to have anti-inflammatory, antioxidant, antiproliferative, antimicrobial activities. Medicinal plants are cheaper, more accessible to most of the population in the world. Thus, there is need to encourage the use of medicinal plants as potential sources of new drugs. [ABSTRACT FROM AUTHOR]