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4. Selective use of radiological staging in node‐positive stage II breast cancer patients may have a role in treatment.

Author

Leem, Chaey, Wang, Yijiao, Kirkpatrick, Joshua, and Juhasz, Eva

Subjects
BREAST cancer, CANCER patients, SENTINEL lymph nodes
Abstract

Background: Advanced‐staging radiography is used inconsistently for patients with early‐stage (stage I + II) breast cancer. However, accurate and appropriate staging of newly diagnosed breast cancer may significantly impact treatment decisions. Methods: Four hundred and ninety‐nine patients with stages II and III breast cancer were seen in the breast service at Waitemata DHB, New Zealand from 2013 to 2018 were enrolled in the study and audited for radiological staging. Results: One hundred and two stage II patients had computed tomography (CT) at baseline; 88 of 102 (86%) of stage II patients were node‐positive (≥N1) with six patients (6.8%) having distant metastatic disease, and were upstaged to stage IV. Fifty‐two stage III patients out of 72 (72%) had baseline staging CTs. Nine out of 52 patients (17%) of stage III patients were upstaged to stage IV. Despite guideline recommendations, baseline staging for T4 disease (stage IIIB) was poor, with only 7 out of 13 patients with stage IIIB disease radiologically staged. Conclusion: Consideration for baseline radiological staging should be given to stages II and III, cN1 breast cancer patients, in which diagnosis of distant metastatic disease would change the treatment plan. Regional guidelines for baseline radiological staging for breast cancer patients may have an impact on patient management in breast cancer patients. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Expression of Somatostatin Receptor Subtypes (SSTR-1–SSTR-5) in Pediatric Hematological and Oncological Disorders

Author

Harda, Kristof, Szabo, Zsuzsanna, Juhasz, Eva, Dezso, Balazs, Kiss, Csongor, Schally, Andrew V., and Halmos, Gabor

Subjects
Male, endocrine system, Adolescent, Age Factors, Infant, Models, Biological, Article, somatostatin analogs, Gene Expression Regulation, Neoplastic, lcsh:QD241-441, lcsh:Organic chemistry, Child, Preschool, Hematologic Neoplasms, Neoplasms, somatostatin receptors, Humans, Female, hematological-oncological disorders in children, Receptors, Somatostatin, Child, hormones, hormone substitutes, and hormone antagonists, Follow-Up Studies, Protein Binding
Abstract

Hematological and oncological disorders represent leading causes of childhood mortality. Neuropeptide somatostatin (SST) has been previously demonstrated in various pediatric tumors, but limited information exists on the expression and characteristics of SST receptors (SSTR) in hematological and oncological disorders of children. We aimed to investigate the expression of mRNA for SSTR subtypes (SSTR-1&ndash, 5) in 15 pediatric hematological/oncological specimens by RT-PCR. The presence and binding characteristics of SSTRs were further studies by ligand competition assay. Our results show that the pediatric tumor samples highly expressed mRNA for the five SSTR subtypes with various patterns. The mRNA for SSTR-2 was detected in all specimens independently of their histological type. A Hodgkin lymphoma sample co-expressed mRNA for all five SSTR subtypes. SSTR-3 and SSTR-5 were detected only in malignant specimens, such as rhabdomyosarcoma, Hodgkin lymphoma, acute lymphoblastic leukemia, and a single nonmalignant condition, hereditary spherocytosis. The incidence of SSTR-1 and SSTR-4 was similar (60%) in the 15 specimens investigated. Radioligand binding studies demonstrated the presence of specific SSTRs and high affinity binding of SST analogs in pediatric solid tumors investigated. The high incidence of SSTRs in hematological and oncological disorders in children supports the merit of further investigation of SSTRs as molecular targets for diagnosis and therapy.

Published
2020

12. Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial

Author

Galimberti, Viviana, primary, Cole, Bernard F, additional, Viale, Giuseppe, additional, Veronesi, Paolo, additional, Vicini, Elisa, additional, Intra, Mattia, additional, Mazzarol, Giovanni, additional, Massarut, Samuele, additional, Zgajnar, Janez, additional, Taffurelli, Mario, additional, Littlejohn, David, additional, Knauer, Michael, additional, Tondini, Carlo, additional, Di Leo, Angelo, additional, Colleoni, Marco, additional, Regan, Meredith M, additional, Coates, Alan S, additional, Gelber, Richard D, additional, Goldhirsch, Aron, additional, Boyle, Fran, additional, Jerusalem, Guy, additional, Stahel, Rolf, additional, Aebi, Stefan, additional, Green, Michael, additional, Karlsson, Per, additional, Kössler, Ingrid, additional, Láng, Istvan, additional, Hiltbrunner, Anita, additional, Bernhard, Jürg, additional, Fournarakou, Stamatina, additional, Kammler, Roswitha, additional, Maibach, Rudolf, additional, Rabaglio, Manuela, additional, Ribi, Karin, additional, Roschitzki, Heidi, additional, Roux, Susanne, additional, Ruepp, Barbara, additional, Mahoney, Caitlin, additional, Price, Karen, additional, Blacher, Lynette, additional, Scolese, Tara, additional, Scott, Karolyn, additional, Lippert, Sandra, additional, Zielinski, Theresa, additional, Mastropasqua, Mauro, additional, Andrighetto, Stefania, additional, Dell'Orto, Patrizia, additional, Renne, Giuseppe, additional, Pruneri, Giancarlo, additional, Dellapasqua, Silvia, additional, Iorfida, Monica, additional, Cancello, Giuseppe, additional, Montagna, Emilia, additional, Cardillo, Anna, additional, Peruzzotti, Giulia, additional, Ghisini, Raffaella, additional, Luini, Alberto, additional, Veronesi, Umberto, additional, Gentilini, Oreste, additional, Zurrida, Stefano, additional, Curigliano, Giuseppe, additional, Nole, Franco, additional, Orecchia, Roberto, additional, Leonardi, Marisa Cristina, additional, Baratella, Paola, additional, Chifu, Camelia, additional, Sargenti, Manuela, additional, Crivellari, Diana, additional, Morassut, Sandro, additional, Mileto, Mario, additional, Piccoli, Erica, additional, Veronesi, Andreas, additional, Magri, Marisa Donatella, additional, Buonadonna, Angelo, additional, Candiani, Ezio, additional, Carbone, Antonino, additional, Perin, Tiziana, additional, Volpe, Rachele, additional, Roncadin, Mario, additional, Arcicasa, Mauro, additional, Coran, Francesco, additional, Lagrassa, Manuela, additional, Recalcati, Angelo, additional, Limonta, Maria Emanuela, additional, Tricomi, Paolo, additional, Fenaroli, Privato, additional, Candiago, Elisabetta, additional, Cattaneo, Laura, additional, Gianatti, Alberto, additional, Santini, Donatella, additional, Maweja, Sylvie, additional, Delvenne, Philippe, additional, Rorive, Andrée, additional, Collignon, Joëlle, additional, Garbay, Jean-Remi, additional, Mathieu, Marie-Christine, additional, Galatius, Hanne, additional, Hoffmann, Jack, additional, Schousen, Peer, additional, Lanng, Charlotte, additional, Hoerby, John, additional, Bruun Rasmussen, Birgitte, additional, Holtveg, Helle, additional, Moeller Talman, Maj-Lis, additional, Abugattas, Julio Elías, additional, Cotrina, Jose Manuel, additional, Dyer, Richard, additional, Lindtner, Jurij, additional, Majdic, Elga, additional, Frkovic-Grazio, Snjezana, additional, Oehlschlegel, Christian, additional, Ries, Gerhard, additional, Töpfer, Michael, additional, Lorenz, Ute, additional, Schiltknecht, Otto, additional, Späti, Bruno, additional, Ehrsam, Andreas, additional, Bamert, Monika, additional, Egli-Tupaj, Martina, additional, Rageth, Christoph, additional, Saurenmann, Elisabeth, additional, Tausch, Christoph, additional, Caduff, Rosmarie, additional, Moch, Holger, additional, Varga, Zsuzsanna, additional, Sarlos, Dimitri, additional, Kralidis, Elena, additional, Grobholz, Rainer, additional, Pagani, Olivia, additional, Bronz, Lucia, additional, Ghielmini, Michele, additional, Mazzucchelli, Luca, additional, Rusca, Tiziana, additional, Gyr, Thomas, additional, Leidi, Linda, additional, Caccia, Giorgio, additional, Wyss, Daniel, additional, Fey, Martin F., additional, Müller, Michael, additional, Günthert, Andreas, additional, Berclaz, Gilles, additional, Fleischmann, Achim, additional, Delaloye, Jean Francois, additional, Treboux, Assia, additional, Lehr, Hans-Anton, additional, Fiche, Maryse, additional, Perey, Lucien, additional, Zaman, Lucien, additional, Jeanneret Sozzi, Wendy, additional, Forbes, John, additional, Lindsay, D.F., additional, Preece, D.F., additional, Hill, Jane, additional, Jeal, P., additional, Smart, P., additional, Collins, John, additional, Mann, Gregory Bruce, additional, Millar, Robert, additional, Murphy, Craig, additional, Buchanan, Malcolm, additional, Murugasu, Anand, additional, French, James, additional, Elder, Elisabeth, additional, Mann, Lynette, additional, Moon, David, additional, Bilous, A. Michael, additional, Pathmanathan, Nirmala, additional, Howard, Virginia, additional, Gill, Petere G., additional, Kollias, James, additional, Bochner, Melissa, additional, Madigan, Linda, additional, Rippy, Elisabeth, additional, Whitfield, Robert, additional, Farshidi, Fereshte, additional, Moore, Katrina, additional, Sywak, Mark, additional, Tan, L., additional, Ross, William, additional, Briscoe, Karen, additional, Jones, Allison, additional, Shah, Aashit, additional, Lim, Elgene, additional, Macindoe, Robert, additional, Spillane, Andrew, additional, Bonar, S. Fiona, additional, Carmalt, Hugh, additional, West, Richard, additional, Mak, Cindy, additional, McKenzie, Paul, additional, Harman, Richard, additional, Gerred, Susanne, additional, Juhasz, Eva, additional, Allpress, Stephen, additional, Craik, Julie, additional, Campbell, Ian, additional, Chin, Paul, additional, Hayes, Lori, additional, Mayall, Frederick, additional, and Thorburn, M., additional

Published
2018
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14. International Epidemiological Differences in Acute Poisonings in Pediatric Emergency Departments

Author

Mintegi, Santiago, Azkunaga, Beatriz, Prego, Javier, Qureshi, Nadeem, Dalziel, Stuart R., Arana-Arri, Eunate, Acedo, Yordana, Martinez-Indart, Lorea, Urkaregi, Arantza, Salmon, Nerea, Benito, Javier, Kuppermann, Nathan, Waisman, Yehezkel, Osmond, Martin, Johnson, David, Chamberlain, James, Macias, Charles G., Kharbanda, Anupam, Babl, Franz E., Dalziel, Stuart, Sutter, Mark, Cohen, Daniel, Lloyd, Julia, Duffy, Elizabeth, Mahajan, Prashant, Wang, George Sam, Bradin, Stuart A., Ramirez, Jose, Stephenson, Samuel, Carison, Anna, Craig, Simon, Graudins, Andis, Cheek, John, Bonish, Megan, Van de Voorde, Patrick, Idrissi, Said Hachimi, Petrovska, Alexandra, Mercier, Jean Christophe, Morin, Laurence, Cheron, Gerard, Szabo, Eva, Nagy, Richard, Bognar, Zsolt, Simon, Gabor, Balla, Gyorgy, Juhasz, Eva, Martin, Ciara, Koshy, Rincy, Mc Namara, Roisin, Waisman, Yehezkel (Hezi), Amir, Lisa, Da Dalt, Liviana, Moretti, Carlo, Norbedo, Stefania, Salvatore, Renna, Debbia, Carla, Arrighini, Alberto, Botarelli, Patrizia, Pisani, Mara, Ponticiello, Eduardo, Tipo, Enzo, Moll, Henriette, Bilhota, Xavier, Garrido, Ana, Gata, Lia, Macao, Patricia, Lima, Sofia Costa, Araujo e Sa, Gabriela, Almeida, Sofia, Gafencu, Mihai, Babeu, Alina, Moldovan, Diana, Mitrofan, Daniela Maria, Humayor Yanez, Francisco Javier, Andres Andres, Ana Gloria, del Campo Munoz, Tomas, Mendivil, Rocio, Baena Olomi, Irene, Fabrega i Sabate, Jordi, Iturralde Orive, Itziar, Roca, Andreu, Fernandez, Ramon, Jorda Lope, Ana, Canduela, Victor, Mesa, Sofia, Garcia-Vao Bel, Carlos, Barasoain Millan, Alberto, Herrero, Laura, Campos Calleja, Carmen, Carlos Molina, Juan, Garcia Herrer, Ma Angeles, Canduela, Carlos, Bello Gutierrez, Pablo, Velasco, Roberto, Martinez Sanchez, Lidia, Martinez Mengual, Laura, Rodriguez Suarez, Julian, Munoz Bernal, Jose Angel, Lopez Avila, Javier, Vazquez Lopez, Paula, May, Elena, Cozar Olmo, Juan, Lopez Corominas, Victoria, Tallon Garcia, Maria, Crespo Ruperez, Esther, Perez Saez, Amalia, Sancosmed Ron, Monica, Velasco Puyo, Pablo, Mesa, Judith, Pociello, Neus, Galan Mercado, Maria, Seiler, Michelle, Gasser, Celine Rey-Bellet, Pittet, Anne, Gervaix, Alain, Manzano, Sergio, Saz, Eylem Ulas, Yurtseven, Ali, Anil, Murat, Oguz, Sinan, Tekin, Deniz, Kurt, Funda, Ryan, Mary, Hoyle, Abi, Lyttle, Mark D., Potter, Sarah, Babakhanlou, Rodrick, and Ege Üniversitesi

Subjects
Pediatric emergency, Male, medicine.medical_specialty, Adolescent, Cross-sectional study, health care facilities, manpower, and services, education, Suicide, Attempted, Poisonings, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Epidemiology, Medicine, Humans, Prospective Studies, Registries, Child, health care economics and organizations, ddc:618, business.industry, Incidence (epidemiology), Incidence, Poisoning, Infant, 030208 emergency & critical care medicine, General Medicine, medicine.disease, global, humanities, Cross-Sectional Studies, Multicenter study, Accidents, Home, Child, Preschool, Pediatrics, Perinatology and Child Health, Acute Disease, Emergency Medicine, epidemiology, Female, Medical emergency, business, Emergency Service, Hospital
Abstract

EgeUn###, Background and Objective: Identifying international differences in the epidemiology of acute poisonings in children may help in improving prevention. We sought to evaluate the international epidemiological differences in acute poisonings in children presenting to emergency departments (EDs) from 8 different global regions. Methods: This was an international multicenter cross-sectional prospective study including children younger than 18 years with acute poisonings presenting to 105 EDs in 20 countries was conducted. Data collection started at each ED between January and September 2013, and continued for 1 year. Results: During the study period, we registered 363,245 pediatric ED presentations, of which 1727 were for poisoning (0.47%; 95% confidence interval, 0.45%-0.50%), with a significant variation in incidence between the regions. Full data were obtained for 1688 presentations. Most poisonings (1361 [80.6%]) occurred at home with either ingestion (1504 [89.0%]) or inhalation of the toxin (126 [7.6%]). Nonintentional exposures accounted for 1157 poisonings (68.5%; mainly in South America and Eastern Mediterranean region), with therapeutic drugs (494 [42.7%]), household products (310 [26.8%]), and pesticides (59 [5.1%]) being the most common toxins. Suicide attempts accounted for 233 exposures (13.8%; mainly in the Western Pacific region and North America), with therapeutic drugs (214 [91.8%], mainly psychotropics and acetaminophen) being the most common toxins. Significant differences between regions were found in both types of poisonings. Recreational poisonings were more common in Europe and Western Pacific region. No patient died. Conclusions: There are substantial epidemiological differences in acute poisonings among children in different countries and regions of the globe. International best practices need to be identified for prevention of acute poisonings in childhood.

Published
2017

15. Contributors

Author

Armouti, Marah, Arnott, John A., Bakshi, Kushal, Bales, Natalie J., Bauer, Mary Beth, Berger, Nathan A., Bernard, Daniel J., Blostein, Mark, Bonet, M. Luisa, Borrow, Amanda P., Brent, Gregory A., Brûlé, Emilie, Cake, Max H., Cantini, Giulia, Chiba, Ayano, Chrousos, George P., Cocciolillo, Sila, Comaposada-Baró, R., Currie, Kevin P.M., De Meyts, Pierre, Dicembrini, Ilaria, Distelhorst, Clark W., Dobos, Nikoletta, Fisher, David E., Franco, M.L., Halmos, Gabor, Handa, Robert J., Hobeika, Elie, Juhasz, Eva, Kala, Hamsini Sudheer, Kemeny, Lajos V., Keri, Ruth A., Kobayashi, Haruka, Kovacs, Christopher S., Kovacs, Kalman, Lefèbvre, Pierre J., Le Henaff, Carole, Le Tissier, P.R., Litwack, Gerald, Liu, Yan-Yun, Sonia Lobo, Luconi, Michaela, Lyons, David J., Ma, Rong, Mallet, Robert T., Mannucci, Edoardo, Milanesi, Anna, Mochizuki, Naoki, Murray, J.F., Nicolaides, Nicolas C., Pantopoulos, Kostas, Partridge, Nicola C., Reddy, Doodipala Samba, Restrepo, Lina M., Ribot, Joan, Richard, Allison J., Rodríguez, Ana M., Romanò, Nicola, Rotondo, Fabio, Schally, Andrew V., Sebastiani, Giada, Serna, Carlos A., Sharifi, Nima, Michael J. Shipston, Stephens, Jacqueline M., Stocco, Carlos, Stover, Sally A., Syro, Luis V., Szabo, Zsuzsanna, Trabucco, Martina, Vilar, M., Volk, David E., Waldum, Helge, Wurtman, Richard J., Yeoh, George C.T., Yu, Yue, and Zakharian, Eleonora

Published
2020
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24. Signaling mechanism of growth hormone-releasing hormone receptor.

Author

Halmos G, Szabo Z, Juhasz E, and Schally AV

Subjects
Humans, Growth Hormone, Receptors, Pituitary Hormone-Regulating Hormone genetics, Receptors, Neuropeptide genetics, Signal Transduction
Abstract

The hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains. Splice variants of GHRH-Rs (SV) in human tumors and other extra pituitary tissues were identified and their cDNA was sequenced. Among the SVs, splice variant 1 (SV1) possesses the greatest similarity to the full-length GHRH-R and remains functional by eliciting cAMP signaling and mitogenic activity upon GHRH stimulation. A large body of work have evaluated potential clinical applications of agonists and antagonists of GHRH in diverse fields, including endocrinology, oncology, cardiology, diabetes, obesity, metabolic dysfunctions, Alzheimer's disease, ophthalmology, wound healing and other applications. In this chapter, we briefly review the expression and potential function of GHRH-Rs and their SVs in various tissues and also elucidate and summarize the activation, molecular mechanism and signalization pathways of these receptors. Therapeutic applications of GHRH analogs are also discussed., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Published
2023
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25. Flap thickness in femtosecond laser.

Author

Juhasz E

Subjects
Humans, Corneal Stroma pathology, Keratomileusis, Laser In Situ methods, Lasers, Excimer therapeutic use, Surgical Flaps pathology
Published
2015

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