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2. Peripheral blood monocyte/macrophages and serum tumor necrosis factor in Kawasaki disease.

Author

Furukawa S, Matsubara T, Jujoh K, Yone K, Sugawara T, Sasai K, Kato H, and Yabuta K

Subjects
Antigens, Differentiation, Child, Preschool, Coronary Aneurysm blood, Coronary Aneurysm immunology, Coronary Aneurysm pathology, Humans, Infant, Leukocyte Count, Mucocutaneous Lymph Node Syndrome immunology, Mucocutaneous Lymph Node Syndrome pathology, Phenotype, Macrophages classification, Monocytes classification, Mucocutaneous Lymph Node Syndrome blood, Tumor Necrosis Factor-alpha blood
Abstract

We analyzed the populations of peripheral blood monocyte/macrophages in 27 patients using a fluorescence-activated cell sorter, and investigated the possibility, in another 30 patients, that tumor necrosis factor (TNF) might be detectable in serum during the acute phase of Kawasaki disease (KD). Percentages of peripheral blood monocyte/macrophages among mononuclear cells and serum TNF levels were both seen to increase during the acute phase of the illness in patients with KD. The percentage of TNF positive cases in KD patients with coronary involvement was higher than that of patients without coronary involvement. These results suggest the possibility that immunological activation, accompanied by the secretion of TNF from monocyte/macrophages, is an important predisposing condition for the exacerbation of vascular damage in KD.

Published
1988
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