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O transplante hepático é o tratamento escolhido para algumas condições graves que afetam o fígado. Durante o processo de preparação para a cirurgia e no período que se segue, o paciente tem de passar um regime de imunossupressão, o que pode torná-lo mais susceptível ao desenvolvimento de infecções secundárias. Como a cavidade oral é um importante veículo de micro-organismos, a eliminação de focos infecciosos de origem bucal é de extrema importância nesses pacientes. Objetivo: Este trabalho objetivou avaliar a necessidade de tratamento endodôntico e de exodontias em 180 pacientes hepatopatas atendidos no Hospital das Clínicas da Universidade Federal de Minas Gerais, uma vez que tais condições atuam como potenciais focos de infecção. Material e Método: Os pacientes atendidos na Faculdade de Odontologia da UFMG tiveram os prontuários analisados para o levantamento dos dados. Resultados: Foram encontradas frequências de 18,7% e 43,3% de necessidade de endodontia nos pacientes pré e pós-transplante, respectivamente. Da mesma forma, a necessidade de extrações dentárias foi de 43,4% e 40%. Conclusões: As altas frequências da necessidade de procedimentos mais invasivos, aliado aos imunossupressores já em uso, demonstram uma alta susceptibilidade desses pacientes para o desenvolvimento de problemas bucais com potencial infeccioso. Dessa forma, é de extrema importância a implementação de protocolos que insiram a Odontologia no atendimento a esse grupo de pacientes como forma de minimizar a ocorrência de infecções que possam interferir ou impedir o sucesso da terapia de transplante Liver transplantation is the treatment of choice for some serious conditions affecting the liver. During the preparation process for the surgery and in the period that follows, the patient has to undergo an immunosuppressive regimen, which may make them more susceptible to the development of secondary infections. As the oral cavity is an important vehicle of microorganisms, the elimination of infectious foci of oral origin is of extreme importance in these patients. Objective: This study aimed to evaluate the need for endodontic and exodontic treatment in 180 patients with liver disease treated at the Hospital das Clínicas of the Federal University of Minas Gerais, as these conditions act as potential foci of infection. Material and Method: Patients attended at the Faculty of Dentistry of UFMG had the charts analyzed for data collection. Results: Frequencies of 18.7% and 43.3% of endodontic need were found in pre and post-transplant patients, respectively. Likewise, the need for dental extractions was 43.4% and 40%. Conclusions: The high frequencies of the need for more invasive procedures, together with immunosuppressants already in use, demonstrate a high susceptibility of these patients to the development of oral problems with infectious potential. Thus, it is extremely important to implement protocols that insert dentistry in the care of this group of patients as a way to minimize the occurrence of infections that may interfere or impede the success of transplant therapy.

To evaluate the mRNA expression levels of cytokines interferon-γ, tumour necrosis factor-α, interleukin IL-1β, IL-10, and the chemokine CCL2/MCP-1, CCL4, and CXCR4 in the periapical interstitial fluid from root canal infections before and after bacterial load reduction in patients undergoing haematopoietic stem cell transplantation (HSCT). The case group was composed of 10 patients undergoing HSCT, and our control group included 10 healthy patients. Clinical samples were taken from teeth with pulp necrosis. Three paper points were placed in the RCS and maintained for 2 min for microbial evaluation before cleaning and shaping procedures. After cleaning and drying the canal, three paper points were introduced into the root canal, passing passively through the root apex (2 mm) into the periapical tissues for 1 min. Samples were collected immediately after root canal cleaning and 7 days later (restrained root canal bacterial load) to characterize gene expression using real-time PCR. The results showed significantly reduction in the microbial load on day 7. An increased expression level of TNF-α and IFN-γ on day 7 in control and case groups was observed (p

To evaluate the selenium (Se) behavior when used as an endodontic dressing in teeth with pulp necrosis. Additionally, its effects was also compared with the calcium hydroxide (C.H.), which is used globally as a root canal dressing, and the combination of the C.H. with Se (C.H. + Se). The sample consisted of 60 patients requiring endodontic treatment who were divided into groups, i.e., without intracanal medication (empty) and with medications as follows: selenium (Se), calcium hydroxide (C.H.), and calcium hydroxide + selenium (C.H. + Se) (n = 15). After the coronary opening, three absorbent paper points were placed in the RCS and maintained for 2 min for microbial evaluation. Following the cleaning and shaping procedures, new paper points were introduced into the root canal system, passing passively through the root apex (2 mm) into the periapical tissues for 2 min, for immune evaluation. The collections were performed again 15 days later. Real-time PCR quantified the expression of the prokaryotic 16S ribosomal RNA. The 16S mRNA was evaluated before the cleaning and shaping procedures and 15 days later in the groups treated with or without medication. A significant reduction in the microbial load was observed only in the groups that received endodontic dressing (p

The aim of this study is to investigate the relationship between the epidemiological and clinical profiles of patients before and after hematopoietic stem cell transplantation (HSCT) and the need for endodontic treatment. The subjects included 188 individuals enrolled in the dental care program for transplanted patients of the School of Dentistry, Federal University of Minas Gerais (Faculdade de Odontologia da Universidade Federal de Minas Gerais, FO-UFMG) from March 2011 through March 2016. The patients were subjected to an HSCT conditioning dental regimen based on a thorough clinical and radiographic evaluation. Intraoral periapical and bite-wing X-rays were obtained, and after evaluation, specific dental treatment was planned and performed. The following demographic and clinical data were collected from the patients’ medical records: age, gender, transplantation stage, primary disease, transplant type, medication used, complete blood count at the time of visit, and need for endodontic treatment. The Kolmogorov-Smirnov and the chi-square tests were used. Leukemia (31.3%) and multiple myeloma (17.9%) were the most prevalent primary diseases. Most patients were subjected to allogeneic-related transplantation (83.6%). Most patients exhibited platelet counts and hemoglobin concentrations below the reference values in the pre-transplantation stage, while the neutrophil and platelet counts and the hemoglobin levels were within the reference ranges in the post-transplantation stage. The proportions of individuals requiring endodontic treatment were similar between the pre- and post-transplantation groups: 24.3% and 24.7%, respectively. The systemic conditions of the patients referred for dental treatment were compromised.

CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico As propriedades e a composição dos cimentos endodônticos podem influenciar nas reações inflamatórias perirradiculares e comprometer o sucesso do tratamento endodôntico. Os macrófagos estão presentes no infiltrado inflamatório periapical, envolvidos na eliminação e controle microbiano nesta região. Este estudo avaliou a atividade de viabilidade celular, aderência, fagocitose da levedura S. boulardii, produção de espécies reativas de oxigênio (ROS), óxido nítrico (NO), e das citocinas (TNF- α e TGF-β) por macrófagos peritoneais murinos de perfil pró-inflamatório (M1) e anti-inflamatório (M2) obtidos de camundongos C57BL/6 e BALB/c, respectivamente. Os macrófagos foram obtidos e a suspensão celular foi colocada em contato com capilares contendo ou não os cimentos Endosequence BC Sealer (BC), Sealer PLus BC (MK), Bio-c Sealer (Ang) e MTA. Mensurou-se a viabilidade celular pelos métodos da exclusão do azul de tripan e por MTT nos tempos 24, 48 e 72 horas. No primeiro ensaio, foi encontrada viabilidade celular semelhante entre os biocerâmicos e o MTA nos tempos testados; no entanto, houve diferença significativa em 72h entre BC e controle (capilar vazio); para o MTT houve diferença com o controle entre: Ang (24h), BC e MK (48h) para M1; para M2, MK (24h), Ang (48h) e BC, Ang, MTA (72h) (p