1. Usefulness of platelet count to predict concomitant valvular heart disease in patients with systemic lupus erythematosus
- Author
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Hiroki Usuku, Eiichiro Yamamoto, Komei Sakata, Shinya Hirata, Ayano Toda, Fumi Oike, Noriaki Tabata, Masanobu Ishii, Shinsuke Hanatani, Tadashi Hoshiyama, Daisuke Sueta, Hisanori Kanazawa, Yuichiro Arima, Seiji Takashio, Yasushi Matsuzawa, Hiroaki Kawano, Jun-ichirou Yasunaga, and Kenichi Tsujita
- Subjects
Platelet count ,Valvular heart disease ,Systemic lupus erythematosus ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Although the prevalence rate of valvular heart disease (VHD) is high in patients with systemic lupus erythematosus (SLE), the predictive factors of concomitant VHD have not been fully evaluated. Methods and results: Among 288 patients with SLE who underwent transthoracic echocardiography at Kumamoto University Hospital from 2016 to 2021, 241 patients with sufficient echocardiographic data were retrospectively analysed. Among them, 22 (9 %) had VHD (10 had mitral regurgitation, 3 had aortic regurgitation, 6 had tricuspid regurgitation, 1 had mitral regurgitation and tricuspid regurgitation, and 2 had a prosthetic cardiac valve). After excluding the two patients with a prosthetic cardiac valve, we divided the remaining patients into two groups: the VHD group and non-VHD group. Multivariate logistic regression analysis revealed that age and the platelet count were significantly and independently associated with having VHD (age: odds ratio, 1.06; 95 % confidence interval, 1.02–1.10; p
- Published
- 2024
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