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2. CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia

Author

Ninomiya, Toshiharu, Hata, Jun, Shibata, Mao, Honda, Takanori, Ohara, Tomoyuki, Akiyama, Masato, Nakaji, Shigeyuki, Murashita, Koichi, Mikami, Tatsuya, Jung, Songee, Misawa, Mina, Maeda, Tetsuya, Ishizuka, Naoki, Akasaka, Hiroshi, Terayama, Yasuo, Yonezawa, Hisashi, Takahashi, Junko, Ono, Kenjiro, Noguchi-Shinohara, Moeko, Komatsu, Junji, Shibata, Shutaro, Yuki-Nozaki, Sohshi, Mimura, Masaru, Bun, Shogyoku, Niimura, Hidehito, Shikimoto, Ryo, Kida, Hisashi, Nakashima, Kenji, Fukada, Yasuyo, Kowa, Hisanori, Nakano, Toshiya, Wada, Kenji, Kishi, Masafumi, Ozaki, Tomoki, Tachibana, Ayumi, Yoshino, Yuta, Shu-ichi Ueno, Jun-ichi Iga, Takebayashi, Minoru, Ishikawa, Tomohisa, Yuki, Seiji, Koyama, Asuka, Kajitani, Naoto, Hashimoto, Mamoru, Ikeda, Manabu, Kokubo, Yoshihiro, Uchida, Kazuhiro, Esaki, Midori, Taki, Yasuyuki, Tatewaki, Yasuko, Thyreau, Benjamin, Yonemoto, Koji, Yoshida, Hisako, Muto, Kaori, Inoue, Yusuke, Ri, Izen, Momozawa, Yukihide, Terao, Chikashi, Kubo, Michiaki, Kiyohara, Yutaka, Maki, Kenji, Hirabayashi, Naoki, Sakata, Satoko, Furuta, Yoshihiko, Yamasaki, Keisuke, Kitazono, Takanari, and Iga, Jun-ichi

Published
2023
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5. Correction: Kanda et al. Body Compression Corrective Garment and Eating Behavioural Change for Weight Reduction: The Mutsu City Randomised Controlled Trial. Healthcare 2023, 11, 942

Author

Kanda, Akira, primary, Sugimura, Yoshikuni, additional, Ohishi, Hideki, additional, Tatebayashi, Satoru, additional, Sawada, Kaori, additional, Wai, Kyi Mar, additional, Nishiguchi, Kei, additional, Tanabu, Asano, additional, Jung, Songee, additional, Murashita, Koichi, additional, Nakaji, Shigeyuki, additional, and Ihara, Kazushige, additional

Published
2024
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8. Lifestyle parameters of Japanese agricultural and non-agricultural workers aged 60 years or older and less than 60 years: A cross-sectional observational study

Author

Kinoshita, Fumie, primary, Yoshida, Kei, additional, Fujitani, Masaya, additional, Imai, Yuta, additional, Kobayashi, Yumiko, additional, Ito, Tomoya, additional, Okumura, Yuto, additional, Sato, Hiroyuki, additional, Mikami, Tatsuya, additional, Jung, Songee, additional, Hirakawa, Akihiro, additional, and Nakatochi, Masahiro, additional

Published
2023
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12. Body Compression Corrective Garment and Eating Behavioural Change for Weight Reduction: The Mutsu City Randomised Controlled Trial

Author

Kanda, Akira, primary, Sugimura, Yoshikuni, additional, Ohishi, Hideki, additional, Tatebayashi, Satoru, additional, Sawada, Kaori, additional, Wai, Kyi Mar, additional, Nishiguchi, Kei, additional, Tanabu, Asano, additional, Jung, Songee, additional, Murashita, Koichi, additional, Nakaji, Shigeyuki, additional, and Ihara, Kazushige, additional

Published
2023
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13. CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia

Author

Maki, Kenji, primary, Ohara, Tomoyuki, additional, Hata, Jun, additional, Shibata, Mao, additional, Hirabayashi, Naoki, additional, Honda, Takanori, additional, Sakata, Satoko, additional, Furuta, Yoshihiko, additional, Akiyama, Masato, additional, Yamasaki, Keisuke, additional, Tatewaki, Yasuko, additional, Taki, Yasuyuki, additional, Kitazono, Takanari, additional, Mikami, Tatsuya, additional, Maeda, Tetsuya, additional, Ono, Kenjiro, additional, Mimura, Masaru, additional, Nakashima, Kenji, additional, Iga, Jun-ichi, additional, Takebayashi, Minoru, additional, Ninomiya, Toshiharu, additional, Nakaji, Shigeyuki, additional, Murashita, Koichi, additional, Jung, Songee, additional, Misawa, Mina, additional, Ishizuka, Naoki, additional, Akasaka, Hiroshi, additional, Terayama, Yasuo, additional, Yonezawa, Hisashi, additional, Takahashi, Junko, additional, Noguchi-Shinohara, Moeko, additional, Komatsu, Junji, additional, Shibata, Shutaro, additional, Yuki-Nozaki, Sohshi, additional, Bun, Shogyoku, additional, Niimura, Hidehito, additional, Shikimoto, Ryo, additional, Kida, Hisashi, additional, Fukada, Yasuyo, additional, Kowa, Hisanori, additional, Nakano, Toshiya, additional, Wada, Kenji, additional, Kishi, Masafumi, additional, Ozaki, Tomoki, additional, Tachibana, Ayumi, additional, Yoshino, Yuta, additional, Shu-ichi Ueno, Jun-ichi Iga, additional, Ishikawa, Tomohisa, additional, Yuki, Seiji, additional, Koyama, Asuka, additional, Kajitani, Naoto, additional, Hashimoto, Mamoru, additional, Ikeda, Manabu, additional, Kokubo, Yoshihiro, additional, Uchida, Kazuhiro, additional, Esaki, Midori, additional, Thyreau, Benjamin, additional, Yonemoto, Koji, additional, Yoshida, Hisako, additional, Muto, Kaori, additional, Inoue, Yusuke, additional, Ri, Izen, additional, Momozawa, Yukihide, additional, Terao, Chikashi, additional, Kubo, Michiaki, additional, and Kiyohara, Yutaka, additional

Published
2023
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14. Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study

Author

Fuke, Nobuo, primary, Yamashita, Takahiro, additional, Shimizu, Sunao, additional, Matsumoto, Mai, additional, Sawada, Kaori, additional, Jung, Songee, additional, Tokuda, Itoyo, additional, Misawa, Mina, additional, Suzuki, Shigenori, additional, Ushida, Yusuke, additional, Mikami, Tatsuya, additional, Itoh, Ken, additional, and Suganuma, Hiroyuki, additional

Published
2023
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15. Application of state-space model with skew-t measurement noise to blood test value prediction

Author

Masanori Kakuta, Rui Yamaguchi, Itoyo Tokuda, Masataka Ando, Jung Songee, Seiya Imoto, Koichi Murashita, and Takanori Hasegawa

Subjects
State-space representation, Computer science, Applied Mathematics, Gaussian, Skew, Value (computer science), Noise, symbols.namesake, Distribution (mathematics), Consistency (statistics), Modeling and Simulation, symbols, Algorithm, Smoothing
Abstract

State-space models (SSMs) have been widely used for analyzing time-series data in the fields of economics and bioinformatics to express the dynamic behavior of data. Recently, filtering and smoothing algorithms applied to linear discrete SSMs with skewed and heavy-tailed measurement noise have been proposed for a more appropriate model because measurement noise does not often follow a Gaussian distribution. In this paper, we propose a linear SSM with skew-t measurement noise for predicting blood test values, along with a method for estimating their parameter values to ensure consistency with the data when using a generalized expectation-maximization (EM) algorithm. To validate the effectiveness of the proposed model and method, we analyze time-series blood test data using both Gaussian and skew-t measurement noise and compared their prediction accuracy for future values. Then, we predicted future blood test values of the unhealthy participant under his current and improved lifestyles. By comparing these predicted results under different lifestyles, we demonstrate that he will overcome lifestyle-related diseases with the improved lifestyle.

Published
2021
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16. The influence of gut microbiome on progression of overactive bladder symptoms: a community-based 3-year longitudinal study in Aomori, Japan

Author

Teppei Okamoto, Tatsuya Mikami, Yoshiharu Okuyama, Kai Ozaki, Chikara Ohyama, Jung Songee, Shingo Hatakeyama, and Daichi Sasaki

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Urinary urgency, Exacerbation, Urology, Japan, Internal medicine, medicine, Humans, Longitudinal Studies, Microbiome, Risk factor, Irritable bowel syndrome, Aged, Urinary Bladder, Overactive, business.industry, Streptococcus, Community Health Centers, Odds ratio, Middle Aged, medicine.disease, Gastrointestinal Microbiome, Overactive bladder, Nephrology, Disease Progression, Female, medicine.symptom, Metabolic syndrome, business
Abstract

PURPOSE To assess the influence of gut microbiome on overactive bladder (OAB) symptoms progression. METHODS This was a 3-year longitudinal study, Hirosaki in Japan. We assessed OAB symptoms and reviewed the medication records of each subject in 2016. We extracted 16S rRNA genes from fecal samples and analyzed gut microbiomes via next-generation sequencing. We evaluated the changes in urinary urgency (UU) and/or urgent urinary incontinence (UUI) from 2016 to 2019. We defined UU/UUI-progression as exacerbation of UU and/or UUI. We compared the clinical backgrounds and microbiota structure between UU/UUI-progression subjects and non-progression (controls). We assessed the impact of gut microbiome on the UU/UUI-progression via multivariate logistic regression analyses. RESULTS Of 669 subjects, 126 were UU/UUI-progression subjects. These subjects had a higher age and prevalence of proton pump inhibitor (PPI) use (14% vs. 5.4%, P = 0.003), irritable bowel syndrome, sleep disturbance, and metabolic syndrome than those without. We found the different microbiota structures between subjects with UU/UUI-progression and those without. A higher relative abundance of genus Streptococcus (harmful bacterial genus for human health) appeared in UU/UUI-progression subjects (3.8% vs. 2.3%, P

Published
2021
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23. Relationship between the cross-sectional area of the lumbar dural sac and lower urinary tract symptoms: A population-based cross-sectional study

Author

Oyama, Tetsushi, primary, Wada, Kanichiro, additional, Koyama, Kazushige, additional, Kumagai, Gentaro, additional, Tanaka, Sunao, additional, Asari, Toru, additional, Imai, Atsushi, additional, Okamoto, Teppei, additional, Hatakeyama, Shingo, additional, Jung, Songee, additional, Sugimura, Yoshikuni, additional, Ohyama, Chikara, additional, and Ishibashi, Yasuyuki, additional

Published
2022
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24. Impact of Sedentary Time on Chronic Kidney Disease and Disability Incidence in Community-Dwelling Japanese Older Adults: A 4-Year Prospective Cohort Study.

Author

Lee, Sungchul, Lee, Sangyoon, Bae, Seongryu, Harada, Kazuhiro, Jung, Songee, Makino, Keitaro, and Shimada, Hiroyuki

Subjects
OLDER people with disabilities, CHRONIC kidney failure, CONFIDENCE intervals, GLOMERULAR filtration rate, LONG-term care insurance, LONGITUDINAL method, REGRESSION analysis, DISEASE incidence, PROPORTIONAL hazards models, SEDENTARY lifestyles
Abstract

This study examined the association between the estimated glomerular filtration rate (eGFR) and disability incidence according to sedentary time in community-dwelling Japanese older adults. This prospective cohort study sampled 5,104 community-dwelling older adults (≥65 years) enrolled in a health promotion study in a general population. The participants (n = 4,457; ≥65 years) were monitored for inclusion in the long-term care insurance system for 4 years. This study used blood samples to assess eGFR. Cox proportional regression analysis was used to determine predictors of disability. In total, 461 participants (10.3%) became newly certified as needing long-term care insurance services. Cox regression models were adjusted for multiple confounders: eGFR < 45 ml/min/1.73 m2 (hazard ratio = 1.741, 95% confidence interval [1.193–2.539]) and eGFR < 45 ml/min/1.73 m2 with high sedentary time (≥8 hr) (hazard ratio = 4.367, 95% confidence interval [2.021–9.438]) remained significantly associated with disability incidence. Our findings suggest that in the case of chronic kidney disease, the disability incidence rate may be affected by sedentary time. [ABSTRACT FROM AUTHOR]

Published
2019
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30. The impact of microalbuminuria on overactive bladders: Results from a community-based four-year longitudinal study in Japan

Author

Takahiro Yoneyama, Jung Songee, Itsuto Hamano, Hayato Yamamoto, Chikara Ohyama, Yasuhiro Hashimoto, Akiko Okamoto, Shingo Hatakeyama, Naoki Fujita, Teppei Okamoto, Masataka Ando, Atsushi Imai, and Tohru Yoneyama

Subjects
Adult, Male, medicine.medical_specialty, Brachial Artery, Urology, 030232 urology & nephrology, Pulse Wave Analysis, Pittsburgh Sleep Quality Index, 03 medical and health sciences, 0302 clinical medicine, Vascular Stiffness, Japan, Risk Factors, Internal medicine, medicine, Albuminuria, Humans, Ankle Brachial Index, Longitudinal Studies, Risk factor, Aged, 030219 obstetrics & reproductive medicine, business.industry, Urinary Bladder, Overactive, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Overactive bladder, Creatinine, Arterial stiffness, Microalbuminuria, Female, Neurology (clinical), medicine.symptom, business
Abstract

Aims To investigate the longitudinal association of microalbuminuria with overactive bladder (OAB). Methods This longitudinal study investigated 561 participants of the Iwaki Health Promotion Project in both 2015 and 2019 in Japan. Microalbuminuria and OAB symptoms were assessed using the urine albuminuria creatinine ratio (ACR) and the overactive bladder symptom score (OABSS), respectively. Urine ACR was defined as high if ≥9.3 mg/gCr. Differences in OABSS between 2015 and 2019 were evaluated as ∆OABSS. Participants were divided into two groups according to ΔOABSS: high (ΔOABSS > 1) and control (≤1). We used baseline data acquired in 2015, such as urine ACR, the Pittsburgh Sleep Quality Index (PSQI), and arterial stiffness expressed by brachial-ankle pulse wave velocity (baPWV). Predictive factors of a ΔOABSS > 1 were assessed by multivariable logistic regression analysis. Results This study included 332 women and 229 men. Of those, 86 (34 males and 52 females) were classified into the ΔOABSS > 1 group. There were significant group differences in age, renal function, and hemoglobin A1c. Participants in the ΔOABSS > 1 had a higher prevalence of PSQI > 5, baPWV ≥ 1400 seconds/cm, and urine ACR ≥ 9.3 mg/gCr (49% vs 20%, P = .001) than those in the control group. Multivariable analysis revealed that PSQI > 5 (odds ratio [OR], 2.57; 95% confidence interval [CI], 1.15-4.60; P = .002) and urine ACR ≥ 9.3 mg/gCr (OR, 1.93; 95% CI, 1.15-3.23; P = .013) were independent risk factors for ΔOABSS > 1. Conclusions Microalbuminuria may be an independent risk indicator for OAB symptom exacerbation.

Published
2020

42. Daily Physical Activity and Functional Disability Incidence in Community-Dwelling Older Adults with Chronic Pain: A Prospective Cohort Study.

Author

Makino, Keitaro, Lee, Sangyoon, Lee, Sungchul, Bae, Seongryu, Jung, Songee, Shinkai, Yohei, and Shimada, Hiroyuki

Subjects
ACCELEROMETERS, BACKACHE, CHRONIC pain, CONFIDENCE intervals, GERIATRIC assessment, LONG-term care insurance, LONGITUDINAL method, RISK assessment, STATISTICS, DATA analysis, INDEPENDENT living, DISEASE incidence, PROPORTIONAL hazards models, RECEIVER operating characteristic curves, PHYSICAL activity, KNEE pain, ODDS ratio, OLD age
Abstract

Objective This study examined the association between daily physical activity and functional disability incidence in community-dwelling older adults with chronic pain. Design Prospective cohort study. Setting Japanese community. Subjects Of the 5,257 participants enrolled for baseline assessment, data on the 693 participants who had chronic lower back or knee pain and underwent daily physical activity assessment using an accelerometer were analyzed. Methods Participants were assessed for regular physical activity (step counts, moderate- to vigorous-intensity physical activity duration, and light-intensity physical activity duration) using an accelerometer at baseline and were followed up for monthly functional disability incidence, based on the national long-term care insurance system, for approximately two years. We determined the effect of physical activity cutoff points on functional disability incidence using receiver operating characteristic curves and Youden index. Cox proportional hazards regression models were used to analyze associations between the cutoff points and disability incidence. Results Among the 693 participants with chronic pain, 69 (10.0%) developed functional disability during the follow-up period. Participants with lower physical activity levels showed significantly higher risk of disability. After adjusting for all covariates, functional disability was associated with step counts (hazard ratio [HR] = 1.79, 95% confidence interval [CI] = 1.02–3.14) and moderate- to vigorous-intensity physical activity duration (HR = 2.02, 95% CI = 1.16–3.51) but had no relationship with light-intensity physical activity duration (HR = 1.72, 95% CI = 0.97–3.05). Conclusions Maintenance of physical activity with at least moderate intensity may be effective in preventing disability even among older adults with chronic pain. [ABSTRACT FROM AUTHOR]

Published
2019
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45. Older Korean adults have lower physical function despite longer exercise times compared to their Japanese counterparts: A Japan‐Korea comparative study.

Author

Jung, Songee, Okubo, Yoshiro, Osuka, Yosuke, Seino, Satoshi, Park, Joonsung, Nho, Hosung, and Tanaka, Kiyoji

Subjects
*SELF-evaluation, *EXERCISE, *INDEPENDENT living, *QUESTIONNAIRES, *MULTIPLE regression analysis, *ANALYSIS of covariance, *MULTIVARIATE analysis, *WALKING, *MOUNTAINEERING, *CYCLING, *RESISTANCE training, *GERIATRIC assessment, *COMPARATIVE studies, *PHYSICAL activity
Abstract

Aim: We aimed to compare the level of physical function (PF) and habitual exercise between older Japanese and Korean adults. Methods: A comparative study was carried out on 1069 community‐dwelling older Japanese and Korean adults (mean age 73.9 ± 5.2 years). The participants were asked to complete a self‐reported questionnaire regarding habitual exercise and covariates. PF age, a composite measure of PF, was derived from the 12 items, using principal component analysis. PF age and habitual exercise were compared between the Japanese and Korean adults, using analysis of covariance ( ancova) and multivariable logistic regression analysis adjusted for all covariates using propensity scores. Results: ancova showed that PF age in older Japanese adults was significantly younger than in their Korean counterparts. Older Japanese adults exercised significantly less frequently than their Korean counterparts. Furthermore, older Japanese adults practiced significantly less walking, mountain climbing and bicycling, but more calisthenics, resistance training, ball games and dances than their Korean counterparts. Conclusions: We found that older Korean adults had lower PF (3.7 years older in PF age) than their Japanese counterparts. Although the overall frequency and amount of habitual exercise in older Korean adults were higher than those in their Japanese counterparts, particular types of exercise might have contributed to the higher PF levels among older Japanese adults. Thus, older Korean adults might need to engage more in habitual exercises that are specifically effective in maintaining PF. Geriatr Gerontol Int 2018; 18: 576–583. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Age Scale for Assessing Activities of Daily Living

Author

Figueroa, Rafael, Seino, Satoshi, Yabushita, Noriko, Okubo, Yoshiro, Osuka, Yosuke, Nemoto, Miyuki, Jung, Songee, Tanaka, Kiyoji, Figueroa, Rafael, Seino, Satoshi, Yabushita, Noriko, Okubo, Yoshiro, Osuka, Yosuke, Nemoto, Miyuki, Jung, Songee, and Tanaka, Kiyoji

Abstract

The purpose of this study was to develop an age scale for assessing activities of daily living (ADL) among community-dwelling adults aged 75 years or older. Participants were 1006 older Japanese: 312 men (79.6 ± 4.3 years) and 694 women, (79.9 ± 5.5 years). Participants completed a battery of 8 performance tests related to ADL and the Barthel index (BI) questionnaire. Spearman rank-order correlation analysis was applied to obtain the correlation of the 8 ADL performance tests with the total BI score. Three variables were high rank-order correlated with BI, secondly those items were subjected to the principal component analysis. The weighted combination of the principal component scores was summed. Resulting in an ADL score (ADLS), women = 0.075 X1 – 0.082 X2 – 0.063 X3 + 0.124, men = 0.051 X1 – 0.105 X2 – 0.099 X3 + 0.249, where X1 = hand-grip strength, X2 = timed up and go, X3 = five-chair sit to stand. Individual ADLS was transformed to an ADL age scale (ADLA). The estimation was – 5.493 ADLS + 79.90 for women, and – 4.272 ADLS + 79.57 for men. Due to the distortion at the regression edges, the equation was corrected as suggested by Dubina et al. ADLA women after correction was = 0.447 (chronological age: CA) – 5.49ADLS + 44.17, men = 0.519CA – 4.27ADLS + 38.26. ADLA can be used to identify or monitor the characteristics of the ADL levels of physical abilities in older Japanese aged 75 years or older.

Published
2015

48. Does attending an exercise class with a spouse improve long-term exercise adherence among people aged 65 years and older: a 6-month prospective follow-up study.

Author

Yosuke Osuka, Songee Jung, Taeho Kim, Yoshiro Okubo, Eunbi Kim, Kiyoji Tanaka, Osuka, Yosuke, Jung, Songee, Kim, Taeho, Okubo, Yoshiro, Kim, Eunbi, and Tanaka, Kiyoji

Subjects
EXERCISE physiology, HEALTH of older people, MARRIED people, REGRESSION analysis, EXERCISE adherence, SOCIAL support, MEDICAL care, WALKING, COMPARATIVE studies, EXERCISE, EXERCISE therapy, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PATIENT compliance, RESEARCH, SELF-efficacy, PSYCHOLOGY of Spouses, SURVEYS, TIME, EVALUATION research, RETROSPECTIVE studies, RESISTANCE training, PSYCHOLOGY
Abstract

Background: Family support can help older adults better adhere to exercise routine, but it remains unclear whether an exercise program targeting older married couples would have stronger effects on exercise adherence than would a program for individuals. The purpose of this study was to determine the effects of an exercise program on the exercise adherence of older married couples over a 24-week follow-up period.Methods: Thirty-four older married couples and 59 older adults participated in this study as couple and non-couple groups (CG and NCG, respectively). All participants attended an 8-week supervised program (once a week and a home-based exercise program comprising walking and strength exercises) and then participated in a follow-up measurement (24 weeks after post-intervention measurement). Exercise adherence was prospectively measured via an exercise habituation diary during the follow-up period-specifically, we asked them to record practice rates for walking (≥2 days/week) and strength exercises (≥6 items for 2 days/week). A multivariate logistic regression analysis was conducted to obtain the CG's odds ratios (ORs) and 95% confidence intervals (CIs) for adherence to walking and strength exercise adjusted for potential confounders (with NCG as the reference).Results: Although the adherence rate of walking exercise in the CG was significantly higher than that in the NCG (29.2%; P < 0.001), there was no significant difference in the adherence rate of strength exercise between the two groups (P = 0.199). The multivariate logistic regression analysis showed that CG had significantly higher odds of adherence to walking exercise compared with the NCG (3.68 [1.57-8.60]). However, the odds of adherence to strength exercise did not significantly differ between the two groups (1.30 [0.52-3.26]).Conclusions: These results suggest that an exercise program targeting older married couples may be a useful strategy for maintaining walking adherence, even six months after the supervised program has ceased. A blinded randomized controlled trial will be needed to confirm this conclusion.Trial Registration: Retrospectively registered. UMIN Clinical Trials Registry (Registered: 02/11/16) UMIN000024689 . [ABSTRACT FROM AUTHOR]

Published
2017
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