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Abstract Background and purpose Glucose-to-glycated hemoglobin ratio (GAR) is considered a more reliable marker of stress hyperglycemia by correcting for basal blood glucose levels. This study aimed to investigate the extent to which GAR is associated with 3 month and 1 year all-cause mortalities in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy (MT). Methods We retrospectively followed 553 AIS patients who underwent MT. The degree of stress hyperglycemia was quantified as the GAR, defined as fasting plasma glucose (mmol/L)/hemoglobin A1c (HbA1c) (%) on the second day after admission. According to the GAR quartiles, the patients were further categorized into four groups (group 1-group 4). We assessed the association between GAR and all-cause mortalities, clinical outcomes during hospitalization and function outcomes at 3 months. The associations between stress hyperglycemia and all-cause mortalities were analyzed using a Cox proportional-hazards model, while other outcomes were analyzed using multiple logistic regression analysis. Results The follow-up lasted a median of 18 months (range 0–66 months). The 3 month mortality rate was 9.58% (n = 53) and the 1 year mortality rate was 18.62% (n = 103). The Kaplan–Meier analysis revealed a significant inverse relationship between GAR and mortality (P

Background and purposeStress hyperglycemia is common in critical and severe diseases. However, few studies have examined the association between stress hyperglycemia and the functional outcomes of patients with anterior circulation stroke, after mechanical thrombectomy (MT), in different diabetes status. This study therefore aimed to determine the relationship between stress hyperglycemia and the risk of adverse neurological functional outcomes in anterior circulation stroke patients with and without diabetes after MT.MethodsData of 408 patients with acute anterior circulation stroke treated with MT through the green-channel treatment system for emergency stroke at the First Affiliated Hospital of Jinan University between January 2016 and December 2020 were reviewed retrospectively. The stress hyperglycemia ratio (SHR) was calculated as fasting plasma glucose (mmol/L) divided by glycosylated hemoglobin (%). The patients were stratified into four groups by quartiles of SHR (Q1-Q4). The primary outcome was an excellent (nondisabled) functional outcome at 3 months after admission (modified Rankin Scale score of 0–1). The relationship between stress hyperglycemia and neurological outcome after stroke was assessed using multivariate logistic regression.ResultsAfter adjusting for potential confounders, compared with patients in Q1, those in Q4 were less likely to have an excellent outcome at 3 months (odds ratio [OR], 0.32, 95% confidence interval [CI], 0.14–0.66, p = 0.003), a good outcome at 3 months (OR, 0.41, 95% CI, 0.20–0.84, p = 0.020), and major neurological improvement (OR, 0.38, 95% CI, 0.19–0.73, p = 0.004). Severe stress hyperglycemia increased risks of 3-months all-cause mortality (OR, 2.82, 95% CI, 1.09–8.29, p = 0.041) and ICH (OR, 2.54, 95% CI, 1.21–5.50, p = 0.015).ConclusionStress hyperglycemia was associated with a reduced rate of excellent neurological outcomes, and increased mortality and ICH risks in patients with anterior circulation stroke after MT regardless of diabetes status.

In 1988, a 3×1012 s-1 neutron generator named ZF-300 was built at Lanzhou University. The neutron source was used in the programs involving basic nuclear data measurements, irradiation effect researches of materials. Recently, a new intense neutron generator named ZF-400, is being developed for the purposes of fast neutron physics research, such as fast neutron nuclear data measurement by activation method and fission physics. The Cockcroft-Walton accelerator was designed to accelerate the D+ beam of 30 mA to the energy of 400 keV. The designed neutron yields of ZF-400 neutron generator were greater than 5×1010 s-1 for D-D and 5×1012 s-1 for D-T, respectively. In the field of fission physics, a potential-driving model by uniting the empirical asymmetric fission potential and the empirical symmetric fission potential was successfully developed to precisely calculate the pre-neutron-emission mass distributions for neutron-induced actinide nuclei fission. A Monte-Carlo method based on the potential-driving model and Geant4 code was also developed to simulate the fission-fragment yield distribution, kinetic energy distribution and fission neutron spectrum. A twin frisch-grid ionization chamber (TFGIC) detector for the measurement of fission products was also designed and tested. In the field of neutron application technology, in order to meet the development requirements of neutron application technology system, a compact neutron generator with a length of 984 mm and a diameter of 234 mm was successfully developed at Lanzhou University. A bias voltage between the target and the extraction accelerating electrode was produced by a resistance to suppress the secondary electron from the target. D-D neutron yield of the compact neutron generator could be greater than 5×108 s-1 under a pure molybdenum as the drive-in target and the beam energy of 150 keV. The compact neutron generator has the potential to produce D-T neutrons with a yield of more than 1010 s-1. A beam-shaping-assembly (BSA) based on a compact D-T neutron generator was designed for fast neutron radiography, and a fast neutron imaging detector based on micro-channel plates was also developed. Preliminary fast neutron imaging test using D-T neutron generator shows that the spatial resolution of the image is about 500 μm. A detection system to measure 235U enrichment uniformity in nuclear fuel rods based on a compact D-D neutron generator was also designed. Simulation results show that the confidence probability can reach 99% for a relative 235U enrichment deviation of 10% under a D-D neutron yield of 5×108 s-1.