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2. Caffeine and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus : Findings from Clinical and Experimental Studies

Author

Alcubierre, Nuria, Granado-Casas, Minerva, Bogdanov, Patricia, Hernández, Cristina, Ramos, Hugo, Castelblanco, Esmeralda, Real, Jordi, Rubinat-Arnaldo, Esther, Traveset, Alicia, Hernández, Marta, Jurjo, Carmen, Vioque, Jesús, Navarrete-Muñoz, Eva Maria, Simó Canonge, Rafael, Mauricio Puente, Dídac, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Alcubierre N] Avantmedic Center, Lleida, Spain. [Granado-Casas M] Department of Nursing and Physiotherapy, Health Sciences Faculty, University of Lleida, Lleida, Spain. Institute of Biomedical Research in Lleida (IRBLleida), Lleida, Spain. Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain. DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. [Bogdanov P, Hernández C, Ramos H, Simó R] Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain. Grup de Recerca de Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Castelblanco E] DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Endocrinology, Metabolism and Lipid Research Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA, and Vall d'Hebron Barcelona Hospital Campus

Subjects
enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::angiopatías diabéticas::retinopatía diabética [ENFERMEDADES], Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Angiopathies::Diabetic Retinopathy [DISEASES], Nutrition and Dietetics, Coffee consumption, Diabetis no-insulinodependent - Complicacions, Type 2 diabetes, técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Retinal ganglion cell layer, Retinopatia diabètica - Factors de risc, enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo II [ENFERMEDADES], Cafeïna, Heterocyclic Compounds::Alkaloids::Xanthines::Caffeine [CHEMICALS AND DRUGS], Diabetic retinopathy, Caffeine intake, Tea consumption, Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [DISEASES], type 2 diabetes, diabetic retinopathy, caffeine intake, coffee consumption, tea consumption, retinal ganglion cell layer, compuestos heterocíclicos::alcaloides::xantinas::cafeína [COMPUESTOS QUÍMICOS Y DROGAS], Food Science
Abstract

Caffeine intake; Tea consumption; Type 2 diabetes Consumo de cafeína; Consumo de té; Diabetes tipo 2 Consum de cafeïna; Consum de te; Diabetis tipus 2 The aim of this study was to assess the potential benefits of caffeine intake in protecting against the development of diabetic retinopathy (DR) in subjects with type 2 diabetes (T2D). Furthermore, we tested the effect of topical administration of caffeine on the early stages of DR in an experimental model of DR. In the cross-sectional study, a total of 144 subjects with DR and 147 individuals without DR were assessed. DR was assessed by an experienced ophthalmologist. A validated food frequency questionnaire (FFQ) was administered. In the experimental model, a total of 20 mice were included. One drop (5 μL) of caffeine (5 mg/mL) (n = 10) or vehicle (5 μL PBS, pH 7.4) (n = 10) was randomly administered directly onto the superior corneal surface twice daily for two weeks in each eye. Glial activation and retinal vascular permeability were assessed using standard methods. In the cross-sectional study in humans, the adjusted-multivariable model showed that a moderate and high (Q2 and Q4) caffeine intake had a protective effect of DR (odds ratio (95% confidence interval) = 0.35 (0.16–0.78); p = 0.011 and 0.35 (0.16–0.77); p = 0.010, respectively). In the experimental model, the administration of caffeine did not improve either reactive gliosis or retinal vascular permeability. Our results suggest a dose-dependent protective effect of caffeine in the development of DR, while the potential benefits of antioxidants in coffee and tea should also be considered. Further research is needed to establish the benefits and mechanisms of caffeinated beverages in the development of DR. This research was funded by grant PS09/01035 from Instituto de Salud Carlos III. N.A. and M.G-C. held a predoctoral fellowship from ISCIII (FI11/0008) and Ministerio de Educación, Cultura y Deporte (FPU15/03005), respectively. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM; the current study was led by group CB15/00071) and CIBER Epidemiología y Salud Pública (CIBERESP) are an initiative from the Instituto de Salud Carlos III (Plan Nacional de I + D + I and Fondo Europeo de Desarrollo Regional).

Published
2023

3. Caffeine and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: Findings from Clinical and Experimental Studies

Author

Alcubierre, Nuria, primary, Granado-Casas, Minerva, additional, Bogdanov, Patricia, additional, Hernández, Cristina, additional, Ramos, Hugo, additional, Castelblanco, Esmeralda, additional, Real, Jordi, additional, Rubinat-Arnaldo, Esther, additional, Traveset, Alicia, additional, Hernández, Marta, additional, Jurjo, Carmen, additional, Vioque, Jesús, additional, Navarrete-Muñoz, Eva Maria, additional, Simó, Rafael, additional, and Mauricio, Didac, additional

Published
2023
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7. Increased Burden of Cerebral Small Vessel Disease in Patients With Type 2 Diabetes and Retinopathy

Author

Sanahuja, Jordi, primary, Alonso, Núria, additional, Diez, Javier, additional, Ortega, Emilio, additional, Rubinat, Esther, additional, Traveset, Alícia, additional, Alcubierre, Núria, additional, Betriu, Àngels, additional, Castelblanco, Esmeralda, additional, Hernández, Marta, additional, Purroy, Francisco, additional, Arcidiacono, Maria Vittoria, additional, Jurjo, Carmen, additional, Fernández, Elvira, additional, Puig-Domingo, Manuel, additional, Groop, Per-Henrik, additional, and Mauricio, Dídac, additional

Published
2016
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8. Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study

Author

Alcubierre, Nuria, primary, Navarrete-Muñoz, Eva M., additional, Rubinat, Esther, additional, Falguera, Mireia, additional, Valls, Joan, additional, Traveset, Alicia, additional, Vilanova, Maria-Belen, additional, Marsal, Josep Ramon, additional, Hernandez, Marta, additional, Granado-Casas, Minerva, additional, Martinez-Gonzalez, Dolores, additional, Jurjo, Carmen, additional, Franch-Nadal, Josep, additional, Vioque, Jesús, additional, and Mauricio, Didac, additional

Published
2016
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9. Relationship of the adherence to the Mediterranean diet with health-related quality of life and treatment satisfaction in patients with type 2 diabetes mellitus: a post-hoc analysis of a cross-sectional study

Author

Alcubierre, Nuria, primary, Martinez-Alonso, Montserrat, additional, Valls, Joan, additional, Rubinat, Esther, additional, Traveset, Alicia, additional, Hernández, Marta, additional, Martínez-González, Maria Dolores, additional, Granado-Casas, Minerva, additional, Jurjo, Carmen, additional, Vioque, Jesus, additional, Navarrete-Muñoz, Eva Maria, additional, and Mauricio, Didac, additional

Published
2016
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16. Corneal biomechanical properties in floppy eyelid syndrome.

Author

Muniesa M, March A, Sánchez-de-la-Torre M, Huerva V, Jurjo C, Barbé F, and Barbé Illa F

Subjects
Aged, Biomechanical Phenomena, Case-Control Studies, Female, Humans, Intraocular Pressure physiology, Male, Middle Aged, Tonometry, Ocular, Cornea physiology, Elasticity physiology, Eyelid Diseases physiopathology, Muscle Hypotonia physiopathology
Abstract

Purpose: To determine corneal biomechanical properties in patients with floppy eyelid syndrome (FES) and to compare them with eyes of controls., Methods: This case-control study included 208 eyes (72 eyes with FES and 136 without FES) of 107 patients (37 patients with FES and 70 without FES). Patients underwent a complete clinical eye examination that included corneal biomechanical evaluation carried out with the Reichert Ocular Response Analyzer., Results: Corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) were evaluated. Mean CH was significantly lower in patients with FES than in those without FES (9.51 ± 1.56 vs. 11.66 ± 9.11; P < 0.001). These results remained statistically significant after adjusting for age and apnea-hypoapnea index (AHI) (P = 0.028). Mean CRF was 10.02 ± 2.08 in the group of patients with FES and 11.21 ± 5.36 in the group of patients without FES (P = 0.001). Mean IOPcc was 17.7 ± 4.8 in patients with FES and 16.3 ± 4.4 in those without FES (P = 0.036). After adjusting for age and AHI, these differences in CRF and IOPcc were not statistically significant (P = 0.26 and P = 0.87, respectively). No statistically significant difference was found between patients with and without FES for Goldmann-correlated intraocular pressure or CCT., Conclusions: Patients with FES had statistically lower CH values. Our findings suggest that corneal biomechanical properties could be changed in patients with FES, reflecting additional structural changes in FES.

Published
2015
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17. Short-term mitomycin C followed by long-term interferon alpha2beta for conjunctiva-cornea intraepithelial neoplasia.

Author

Huerva V, Mateo AJ, Mangues I, and Jurjo C

Subjects
Administration, Topical, Aged, 80 and over, Biopsy, Carcinoma in Situ pathology, Conjunctival Neoplasms pathology, Corneal Diseases pathology, Eye Neoplasms drug therapy, Eye Neoplasms pathology, Female, Humans, Interferon alpha-2, Interferon-alpha administration & dosage, Mitomycin administration & dosage, Recombinant Proteins, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma in Situ drug therapy, Conjunctival Neoplasms drug therapy, Corneal Diseases drug therapy
Abstract

Purpose: To report a case of extensive conjunctiva-cornea intraepithelial neoplasia (CIN) treated topically with mitomycin C (MMC) and interferon (INF)-alpha2beta without surgical resection., Methods: Case report., Results: : An 82-year-old woman showed an extensive gelatinous red mass in the bulbar conjunctiva with invasion into the caruncle, inferior fornix, and tarsal conjunctiva and extending for 270 degrees of the corneal surface. A diagnosis of CIN was made by surgical biopsy. Surgical excision with safety margins carried the risk of limbal stem cell depletion. A conservative treatment strategy was used with 2 cycles of topical MMC (0.02%), followed by INF-alpha2beta eye drops at a dose of 1 million IU/mL, 4 times a day until tumor disappearance. Total resolution was noted after 75 days of treatment with INF, with no clinical evidence of limbal stem cell deficiency. After 1 year of monitoring, no signs of CIN recurrences were observed., Conclusion: MMC (0.02%), followed by INF-alpha2beta (1 million IU/mL) 4 times a day, is an effective treatment against highly extensive CIN, in cases where surgical resection with safety margins is unfeasible.

Published
2006
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