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In November 2021, a geophysical prospection using magnetics, electromagnetics, and ground penetrating radar, as well as a surface archaeological survey and aerial photography were conducted in the kurgan area on the Uzun-Rama plateau in central Azerbaijan. These non-destructive investigations aim to obtain information on the morphology, structure and spatial distribution of the urgans in order to classify them according to various features. The preliminary results show that increased magnetic field intensity, increased electrical conductivity, and increased reflection energy in the GPR are observed in the top region of the kurgans, which contain information about the burial chamber.

Evidence of gold processing in the fortified site of Bruszczewo (Poland) is the first testimony of the production of gold artefacts in a domestic Early Bronze Age site of Central Europe. This paper highlights the potential of macrolithic tool ensembles as a key element for the recognition of metallurgical work processes. Moreover, it presents an optimised methodological approach to tackle the application of stone tools in metallurgical production, based on technological characterisation, use-wear analysis, portable X-ray fluorescence, transmission electron microscopy and energy dispersive X-ray spectroscopy. Finally, the absence of gold sources in Central Europe raises the question about the origin of the metal, constituting an especially striking issue, as gold was a raw material of restricted access. As Bruszczewo was one of the few enclosed Early Bronze Age sites north of the Central European Mountain Range, the patterning of metal processing (including gold) sheds light on the mode of the production of metal artefacts, apparently restricted to central sites of power, which controlled the communication trails. 47 Journal of Archaeological Science: Reports

Die Ergebnisse experimenteller und epidemiologischer Studien deuten darauf hin, dass Diabetes die Risiken fur bestimmte gastrointestinale und gynakologische Tumoren erhoht. Am besten belegt ist dies hinsichtlich des Typ-2-Diabetes, wobei ahnliche Zusammenhange fur Pradiabetes, Gestationsdiabetes und Typ-1-Diabetes beschrieben sind. Mechanistisch ist dies auf tumorfordernde Eigenschaften einer hochregulierten Insulin-IGF-1-Achse (IGF: „insulin-like growth factor“) und auf Hyperglykamien zuruckzufuhren. Zudem tragen adipositasassoziierte Stoffwechselveranderungen wesentlich zum Krebsrisiko bei. Daten aus Beobachtungsstudien, die niedrigere Krebsrisiken unter Metformin- vs. Insulintherapie suggerieren, sind mit Vorsicht zu interpretieren. Derzeit wird der tertiarpraventive Nutzen von Metformin unter Krebspatienten mit und ohne Diabetes untersucht. Ansonsten dienen Lebensstilinterventionen und eine gute medikamentose Einstellung in fruhen Phasen der Diabetesentstehung auch der Krebspravention.

This paper aims at reconstructing the population dynamics during the Neolithic and Bronze Age, c. 4500–500 cal. BC, in north-western Central Europe. The approach is based on the assumption that increased population density is positively linked with human activity and human impact on the environment, respectively. Therefore, we use archaeological 14 C dates and palaeoenvironmental data from northern Germany and south-western Denmark to construct and compare independent proxies of human activity. The latter involves relative quantification of human impact based on pollen analysis and soil erosion history inferred from summarizing of dated colluvial layers. Concurring patterns of changes in human activity are frequently recorded on a multi-centennial scale. Whereas such multi-proxy patterns are interpreted to indicate relative population changes, divergent patterns are discussed in the context of proxy-related uncertainties and potential biases. Patterns of temporal distribution of increasing and decreasing human activity are understood as ‘boom and bust’ phases in population density/size. Based on the comparison of the three proxies, we identify five phases of growing (boom) and four phases of decreasing (bust) population. The boom phases date to ca. 4000–3500, 3000–2900, 2200–2100, 1450–1300 and 1000–750 cal. BC. The bust phases to ca. 3200–3000, 2400–2300, 1650–1500 and 1200–1100 cal. BC.

In archaeology, change in material culture is viewed as indicating social or cultural transformation and is the basis of our typo-chronological classification of phases and periods. The material culture from northern Germany reveals both quantitative and qualitative changes during the Bronze Age. At the same time, there is also evidence for ‘boom and bust’ cycles in population density/size, as indicated by changing human impact on the environment in several Bronze Age palaeoenvironmental records. These demographic fluctuations may relate to the observed changes in social phenomena in aspects of ideology, technology, food production and habitation. For example, innovations in food production, such as the adoption of new crops and agricultural techniques, could have led to population growth. While usually viewed by archaeologists as a ‘negative’ development, population stress or collapse may have favoured the emergence of new cultural phenomena. In order to test the cause-and-effect relationship between population dynamics and sociocultural change, we synthesise the archaeological evidence – qualitative and quantitative information from settlements, deposition finds (hoards), burials, material culture and architectural remains – for the Bronze Age in northern Germany, mainly Schleswig-Holstein, and compare it with the boom and bust pattern seen in the palaeoenvironmental record. The synchronicity of changes at ca. 1500 BC and ca. 1100 BC reflects the relationship between phases of major sociocultural transformation in the archaeological datasets and booms and busts in the palaeoenvironmental record of the region seen as a proxies for palaeo-demography. This sets the stage for a better understanding of the transformation of practices and relationships in the Bronze Age communities of the region.

In light of recent climate changes, it is important to also gain knowledge about the spatial manifestation of past climate events and their potential impact on ancient societies across a wide range of different scenarios. Following this approach, we compare compilations of seasonal (winter and summer) as well as annual precipitation and temperature changes to a measure of human activity based on AMS 14C data of settlement sites from the Iberian Peninsula during the Chalcolithic and the Bronze Age – a period of major social turnover. Palaeoclimatic reconstructions show a long-term decrease in winter precipitation between 6000 and 3000 cal. BP (4050–1050 BCE). Superimposed to this long-term aridification trend was the 4.2 ka BP climate event, which manifested itself as a period of abrupt decrease in summer precipitation and/or an elongation of the summer dry period, but probably with constant winter precipitation from 4000 to 3800 cal. BP (2050–1850 BCE), particularly affecting the southeast of the Iberian Peninsula. Additionally, a winter cooling event across the Iberian Peninsula and its marginal seas occurred between 4400 and 4000 cal. BP (2450–2050 BCE) coinciding with Bond Event 3. By comparing human activities to the changes in seasonal and annual precipitation, new insight is gained into the causal relationships between climatic and social dynamics in the past. We show that winter precipitation potentially played a major role for the societies during the Chalcolithic and the Bronze Age of the southern Iberian Peninsula. While the El Argar culture at the south-eastern Iberian Peninsula boomed in spite of enhanced summer drought associated to the 4.2 ka BP climate event, decreasing winter precipitation was potentially contributing to a demographic decline in the southwest after 4800 cal. BP (2850 BCE) as well as to the bust of the El Argar culture in the southeast after 3600 cal. BP (1650 BCE) by limiting the agricultural strategies.

Contrary to pottery or metal artefacts, macro-lithic tools are still not fully integrated into the archaeological research programs concerning the Early Bronze Age of Central Europe. While such kind of archaeological materials usually do not easily allow typological approaches, their constant participation in several productive spheres makes them a crucial element for understanding the economic processes and the organisation of past societies. This paper presents the general results of the investigation carried out on an assemblage of 1073 macro-lithic items recovered in the wet soil area of the site of Bruszczewo (municipality of Śmigiel, Poland). This fortified settlement was inhabited during the Early Bronze Age (2100-1650 BCE) and later on in the Late Bronze Age and Early Iron Age (1100-800 BCE), with minor archaeological evidences from Middle Ages. The methodology applied in this assessment is a holistic one, which combines manufacturing (petrography and morphometry), functional (use-wear and residues) and spatial analyses. This approach has allowed recording a mainly local raw material supplying system, based on the gathering of pebbles in the vicinity of the site and a minimal transformation of raw pieces previous to use. Moreover, Bruszczewo comes out to be a central settlement managing and controlling exogenous ores, such as copper and gold, as shown by residues found on some macro-lithic forging anvils. All in all, the recognition in the macro-lithic tool assemblage of different tasks related to subsistence (food preparation) as well as to manufacture (metallurgy, probably bone working) processes contributes to (a) defining the settlement's organisation and the management of resources in the site and (b) improving our understanding of the role played by central settlements in the socio-economic networks, at a time when the first class societies emerged in Central Europe.

International audience; The Ganja Region Kurgan Archaeological Project (GaRKAP) is a joint Azero-Italian project that aims at investigating the spread of the tradition of burying the dead in large funerary chambers covered with circular tumuli-that is, kurgans-in the southern Caucasus during a period ranging from the fourth to the first millennium BCE. It is in this region that large numbers of kurgans, dating to the Early Bronze Age (that is, the Kura-Araxes period) through to the Iron Age, have been identified. In particular, the funerary tumuli dated to the Kura-Araxes period reveal a common mortuary custom of multiple human depositions inside a large chamber that is burnt at the conclusion of ritual practices; the Late Bronze/ Early Iron Age burials, on the other hand, are smaller in size and usually present single or double human depositions, furnished with bronze objects and, in some circumstances, the skeletal remains of equids. This paper will present the results of the first season of the archaeological work performed in western Azerbaijan, in the Ganja-Gazakh region. More specifically, it is focused on) the city of Ganja, where a series of Late Bronze/Early Iron Age kurgans are located, and) the steppe of Uzun Rama, along the valley of a creek affluent of the Kura River in the Goranboy district, which is marked by the presence of large kurgans dated to the late fourth millennium BCE and characterised by collective burials.* Introduction (N. Laneri and B. Jalilov)

Background Earlier epidemiological studies indicate that associations between obesity and breast cancer risk may not only depend on menopausal status and use of exogenous hormones, but might also differ by tumor subtype. Here, we evaluated whether obesity is differentially associated with the risk of breast tumor subtypes, as defined by 6 immunohistochemical markers (ER, PR, HER2, Ki67, Bcl-2 and p53, separately and combined), in the prospective EPIC-Germany Study (n = 27,012). Methods Formalin-fixed and paraffin-embedded (FFPE) tumor tissues of 657 incident breast cancer cases were used for histopathological analyses. Associations between BMI and breast cancer risk across subtypes were evaluated by multivariable Cox regression models stratified by menopausal status and hormone therapy (HT) use. Results Among postmenopausal non-users of HT, higher BMI was significantly associated with an increased risk of less aggressive, i.e. ER+, PR+, HER2-, Ki67low, Bcl-2+ and p53- tumors (HR per 5 kg/m2: 1.44 [1.10, 1.90], p = 0.009), but not with risk of more aggressive tumor subtypes. Among postmenopausal users of HT, BMI was significantly inversely associated with less aggressive tumors (HR per 5 kg/m2: 0.68 [0.50, 0.94], p = 0.018). Finally, among pre- and perimenopausal women, Cox regression models did not reveal significant linear associations between BMI and risk of any tumor subtype, although analyses by BMI tertiles showed a significantly lower risk of less aggressive tumors for women in the highest tertile (HR: 0.55 [0.33, 0.93]). Conclusion Overall, our results suggest that obesity is related to risk of breast tumors with lower aggressiveness, a finding that requires replication in larger-scale analyses of pooled prospective data. Electronic supplementary material The online version of this article (10.1186/s12885-018-4548-6) contains supplementary material, which is available to authorized users.

The aim of this study was to assess the preventive potential of major lifestyle risk factors for acute myocardial infarction (AMI) in middle-aged men. Among 10,981 men in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition, aged 40.2–65.8 years when recruited, 378 developed first-ever AMI during a median follow-up period of 11.4 years. Current smoking, excess body weight, being physically inactive, but not high alcohol consumption, were identified as the major lifestyle risk factors for AMI using Cox regression analysis. A competing AMI risk model built from cause-specific Cox regression models and considering the risk of death predicted 353 AMI cases, 182 (51.6 %) of which were estimated as preventable through adherence to a healthy lifestyle profile (never smoking, normal body weight, physically active, and moderate alcohol consumption). The calculated age-specific 5-year incidence rates for AMI in the actual cohort and in a hypothetical, comparable cohort with all men following the healthy lifestyle profile were 128 and 39, respectively, per 100,000 person-years for the age group 40–44, increasing to 468 and 307 per 100,000 person-years for the age group 65–69. The estimated AMI incidence rates for men with the healthy lifestyle profile are still somewhat higher than the average rates reported for documented low-incidence regions, such as parts of Japan. Our analysis confirms the strong primary preventive potential for AMI based on avoidance of smoking and excess body weight, and on regular physical activity.

Analysis of organic residues in pottery vessels has been successful in detecting a range of animal and plant products as indicators of food preparation and consumption in the past. However, the identification of plant remains, especially grain crops in pottery, has proved elusive. Extending the spectrum is highly desirable, not only to strengthen our understanding of the dispersal of crops from centres of domestication but also to determine modes of food processing, artefact function and the culinary significance of the crop. Here, we propose a new approach to identify millet in pottery vessels, a crop that spread throughout much of Eurasia during prehistory following its domestication, most likely in northern China. We report the successful identification of miliacin (olean-18-en-3β-ol methyl ether), a pentacyclic triterpene methyl ether that is enriched in grains of common/broomcorn millet (Panicum miliaceum), in Bronze Age pottery vessels from the Korean Peninsula and northern Europe. The presence of millet is supported by enriched carbon stable isotope values of bulk charred organic matter sampled from pottery vessel surfaces and extracted n-alkanoic acids, consistent with a C4 plant origin. These data represent the first identification of millet in archaeological ceramic vessels, providing a means to track the introduction, spread and consumption of this important crop.