210 results on '"Jwa-Min Nam"'
Search Results
2. Dealloyed Intra-Nanogap Particles with Highly Robust, Quantifiable Surface-Enhanced Raman Scattering Signals for Biosensing and Bioimaging Applications
- Author
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Minho Kim, Sung Min Ko, Jae-Myoung Kim, Jiwoong Son, Chungyeon Lee, Won-Kyu Rhim, and Jwa-Min Nam
- Subjects
Chemistry ,QD1-999 - Published
- 2018
- Full Text
- View/download PDF
3. Plasmonic Photothermal Nanoparticles for Biomedical Applications
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Minho Kim, Jung‐Hoon Lee, and Jwa‐Min Nam
- Subjects
metal nanoparticles ,phothermal effect ,photothermal therapy ,plasmonic nanoparticles ,theranostics ,Science - Abstract
Abstract Recent advances of plasmonic nanoparticles include fascinating developments in the fields of energy, catalyst chemistry, optics, biotechnology, and medicine. The plasmonic photothermal properties of metallic nanoparticles are of enormous interest in biomedical fields because of their strong and tunable optical response and the capability to manipulate the photothermal effect by an external light source. To date, most biomedical applications using photothermal nanoparticles have focused on photothermal therapy; however, to fully realize the potential of these particles for clinical and other applications, the fundamental properties of photothermal nanoparticles need to be better understood and controlled, and the photothermal effect‐based diagnosis, treatment, and theranostics should be thoroughly explored. This Progress Report summarizes recent advances in the understanding and applications of plasmonic photothermal nanoparticles, particularly for sensing, imaging, therapy, and drug delivery, and discusses the future directions of these fields.
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- 2019
- Full Text
- View/download PDF
4. Plasmonic Cross-Linking Colorimetric PCR for Simple and Sensitive Nucleic Acid Detection
- Author
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Kunlun Jiang, Jingrui Wu, Ji-Eun Kim, Sujin An, Jwa-Min Nam, Yung-Kang Peng, and Jung-Hoon Lee
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Mechanical Engineering ,General Materials Science ,Bioengineering ,General Chemistry ,Condensed Matter Physics - Published
- 2023
5. Plasmonic quenching and enhancement: metal–quantum dot nanohybrids for fluorescence biosensing
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Niko Hildebrandt, Mihye Lim, Namjun Kim, Da Yeon Choi, and Jwa-Min Nam
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Materials Chemistry ,Metals and Alloys ,Ceramics and Composites ,General Chemistry ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
Plasmonic “Quenchancement”: in this feature article, we discuss the interplay of different quenching and enhancement mechanisms that influence the development of metal–quantum dot nanohybrid biosensors.
- Published
- 2023
6. Conjugation strategies of <scp>DNA</scp> to gold nanoparticles
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Da Yeon Choi, Suhyun Kim, Jeong‐Wook Oh, and Jwa‐Min Nam
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General Chemistry - Published
- 2022
7. Mechanically interlocked gold nanocatenanes
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Yoonhee Kim and Jwa-Min Nam
- Published
- 2022
8. Heterogeneous Component Au (Outer)–Pt (Middle)–Au (Inner) Nanorings: Synthesis and Vibrational Characterization on Middle Pt Nanorings with Surface-Enhanced Raman Scattering
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Soohyun Lee, Insub Jung, Jiwoong Son, Sungwoo Lee, Minsun Park, Ji-Eun Kim, Woocheol Park, Jaewon Lee, Jwa-Min Nam, and Sungho Park
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General Engineering ,General Physics and Astronomy ,General Materials Science - Abstract
We report a synthetic approach for heterometallic (Au-Pt-Au) nanorings with intertwined triple rings (NITs), wherein three differently sized metal circular nanorings concentrically overlap in a single entity. The synthetic method allows one to control the component of core nanorings (Au or Pt) with a tunable gap distance. The narrow circular nanogaps between inner and outer Au rings strongly enhance the electromagnetic near-field
- Published
- 2022
9. FRONT MATTER
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Jwa-Min Nam and Luis M Liz-Marzán
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- 2022
10. BACK MATTER
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Jwa-Min Nam and Luis M Liz-Marzán
- Published
- 2022
11. Enormous Enhancement in Single-Particle Surface-Enhanced Raman Scattering with Size-Controllable Au Double Nanorings
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Jieun Shin, Sungwoo Lee, Sungjae Yoo, Insub Jung, Soohyun Lee, Jeongwon Kim, Jiwoong Son, Ji-Eun Kim, Jae-Myoung Kim, Jwa-Min Nam, and Sungho Park
- Subjects
General Chemical Engineering ,Materials Chemistry ,General Chemistry - Published
- 2022
12. Trends and perspectives in bio- and eco-friendly sustainable nanomaterial delivery systems through biological barriers
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Seongchan Kim, Taegon Oh, Hyojin Lee, and Jwa-Min Nam
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Materials Chemistry ,General Materials Science - Abstract
This review summarizes and provides perspectives on the recent efforts towards the greener synthesis and biomedical delivery applications of various nanoparticles with respect to sustainability.
- Published
- 2022
13. Toward Quantitative Surface-Enhanced Raman Scattering with Plasmonic Nanoparticles: Multiscale View on Heterogeneities in Particle Morphology, Surface Modification, Interface, and Analytical Protocols
- Author
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Jiwoong Son, Gyeong-Hwan Kim, Yeonhee Lee, Chungyeon Lee, Seungsang Cha, and Jwa-Min Nam
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Colloid and Surface Chemistry ,General Chemistry ,Biochemistry ,Catalysis - Abstract
Surface-enhanced Raman scattering (SERS) provides significantly enhanced Raman scattering signals from molecules adsorbed on plasmonic nanostructures, as well as the molecules' vibrational fingerprints. Plasmonic nanoparticle systems are particularly powerful for SERS substrates as they provide a wide range of structural features and plasmonic couplings to boost the enhancement, often up to10
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- 2022
14. Plasmonic Cyclic Au Nanosphere Hexamers
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Jeongwon Kim, Sungwoo Lee, Jiwoong Son, Jieun Kim, Hajir Hilal, Minsun Park, Insub Jung, Jwa‐Min Nam, and Sungho Park
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Biomaterials ,General Materials Science ,General Chemistry ,Biotechnology - Abstract
Rational design of plasmonic colloidal assemblies via bottom-up synthesis is challenging but would show unprecedented optical properties that strongly relate to the assembly's shape and spatial arrangement. Herein, the synthesis of plasmonic cyclic Au nanosphere hexamers (PCHs) is reported, wherein six Au nanospheres (Au NSs) are connected via thin metal ligaments. By tuning Au reduction, six dangling Au NSs are interconnected with a core hexagon nanoplate (NPL). Then, Pt atoms are selectively deposited on the edges of the spheres. After etching of the core, necklace-like nanostructures of Pt framework are obtained. Deposition of Au is followed, leading to PCHs in high yield (≈90%). Notably, PCHs exhibit the combinatorial plasmonic characteristics of individual Au NSs and the in-plane coupling of the six linked Au NSs. They yield highly uniform, reproducible, and polarization-independent single-particle surface-enhanced Raman scattering signals, which are attributed to the 2-dimensional isotropic alignment of the Au NSs. Those are applied to a SERS-based immunoassay as quantitative and qualitative single particle SERS nanoprobes. This assay shows a low limit-of-detection, down to 100 pm, which is orders of magnitude lower than those based on Au NSs, and one order of magnitude lower than an assay using analogous particles of smooth Au nanorings.
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- 2022
15. Announcing the Winner of the Inaugural
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Nanshu, Lu and Jwa-Min, Nam
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- 2022
16. Plasmonically engineered nanogap probes for biosensing and bioimaging applications (Conference Presentation)
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Jwa-Min Nam
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- 2022
17. Plasmonic Dual‐Gap Nanodumbbells for Label‐Free On‐Particle Raman DNA Assays
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Jae‐Myoung Kim, Jiyeon Kim, Kyungin Choi, and Jwa‐Min Nam
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2023
18. Plasmonic Cyclic Au Nanosphere Hexamers (Small 7/2023)
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Jeongwon Kim, Sungwoo Lee, Jiwoong Son, Jieun Kim, Hajir Hilal, Minsun Park, Insub Jung, Jwa‐Min Nam, and Sungho Park
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Biomaterials ,General Materials Science ,General Chemistry ,Biotechnology - Published
- 2023
19. Au nanolenses for near-field focusing
- Author
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Sungho Park, Jiwoong Son, Sungwoo Lee, Soo Hyun Lee, Hajir Hilal, Jwa-Min Nam, Jae-Myoung Kim, Sungjae Yoo, and Eunbyeol Cho
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Electromagnetic field ,Materials science ,Nanoporous ,business.industry ,Near and far field ,General Chemistry ,Electrochemistry ,Ion ,Chemistry ,symbols.namesake ,symbols ,Optoelectronics ,Surface plasmon resonance ,business ,Nanoring ,Raman scattering - Abstract
We report a novel strategy for the synthesis of Pt@Au nanorings possessing near-field focusing capabilities at the center through which single-particle surface enhanced Raman scattering could be readily observed. We utilized Pt@Au nanorings as a light-absorber; the absorbed light could be focused at the center with the aid of a Au nanoporous structure. We synthesized the Au nanolens structure through a Galvanic exchange process between Au ions and Ag block at the inner domain of the Pt@Au nanoring. For this step, Ag was selectively pre-deposited at the inner domain of the Pt@Au nanorings through electrochemical potential-tuned growth control and different surface energies with regard to the inner and outer boundaries of the nanoring. Then, the central nanoporous architecture was fabricated through the Galvanic exchange of sacrificial Ag with Au ions leading to the resulting Au nanoring with a Au nanoporous structure at the center. We monitored the shape-transformation by observing their corresponding localized surface plasmon resonance (LSPR) profiles. By varying the rim thickness of the starting Pt@Au nanorings, the inner diameter of the nanolens was accordingly tuned to maximize near-field focusing, which enabled us to obtain the reproducible and light-polarization independent measurements of single-particle SERS. Through theoretical simulation, the near-field electromagnetic field focusing capability was visualized and confirmed through single-particle SERS measurement showing an enhancement factor of 1.9 × 108 to 1.0 × 109., We synthesized a Au nanolens with electromagnetic near-field focusing capability by integrating a Au nanoporous structure at the center of the Pt@Au nanoring via synthetic steps of eccentric growth of Ag and nanoscale Galvanic exchange reaction.
- Published
- 2021
20. A rapid and sensitive fluorescence biosensor based on plasmonic PCR
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Jiwoong Son, Jung-Hoon Lee, Hyun June Park, Yuwei Qiu, Kunlun Jiang, Jingrui Wu, Jwa-Min Nam, and Hua Mi
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Detection limit ,Gel electrophoresis ,0303 health sciences ,Materials science ,business.industry ,Photothermal effect ,Magnetic separation ,Metal Nanoparticles ,Nanoparticle ,Biosensing Techniques ,02 engineering and technology ,Photothermal therapy ,021001 nanoscience & nanotechnology ,Polymerase Chain Reaction ,Fluorescence ,03 medical and health sciences ,Optoelectronics ,General Materials Science ,0210 nano-technology ,business ,Biosensor ,030304 developmental biology - Abstract
Plasmonic PCR utilizing metallic nanoparticles has shown great advantages compared to the commercial thermocycler equipment in terms of cost, size and processing time. However, due to the strong fluorescence quenching, plasmonic nanoparticle-based PCR requires additional post-processing steps such as centrifugation and gel electrophoresis. This process increases the overall diagnostic time, offsetting the benefits of fast thermocycling. Here, we report a rapid and sensitive plasmonic photothermal PCR (PPT-PCR) assay method based on in situ end-point fluorescence detection. By using plasmonic magnetic bi-functional nanoparticles, PPT-PCR involving 30 thermocycles and fluorescence detection following magnetic separation has successfully shown that DNA targets can be detected within 5.5 minutes. The limit of detection (3.3 copies per μL) is comparable with that of the conventional real-time quantitative PCR; however, the assay time is about 5.5 times shorter for the PPT-PCR. The strategy of combining the photothermal effect and magnetic separation into a single particle will open new horizons in the development of fast and sensitive PCR-based biosensors for point-of care testing.
- Published
- 2021
21. Electrochromic response and control of plasmonic metal nanoparticles
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Jae-Ho Kim, Seungsang Cha, Yoonhee Kim, Jeong-Wook Oh, and Jwa-Min Nam
- Subjects
symbols.namesake ,Materials science ,Electrochromism ,Optoelectronic materials ,Photoelectrochemistry ,Fermi level ,symbols ,General Materials Science ,Nanotechnology ,Surface plasmon resonance ,Metal nanoparticles ,Plasmon ,Plasmonic metamaterials - Abstract
Plasmonic electrochromism, the dependence of the colour of plasmonic materials on the applied electrical potential, has been under the spotlight recently as a key element for the development of optoelectronic devices and spectroscopic tools. In this review, we focus on the electrochromic behaviour and underlying mechanistic principles of plasmonic metal nanoparticles, whose localised surface plasmon resonance occurs in the visible part of the electromagnetic spectrum, and present a comprehensive review on the recent progress in understanding and controlling plasmonic electrochromism. The mechanisms underlying the electrochromism of plasmonic metal nanoparticles could be divided into four categories, based on the origin of the LSPR shift: (1) capacitive charging model accompanying variation in the Fermi level, (2) faradaic reactions, (3) non-faradaic reactions, and (4) electrochemically active functional molecule-mediated mechanism. We also review recent attempts to synchronise the simulation with the experimental results and the strategies to overcome the intrinsically diminutive LSPR change of the plasmonic metal nanoparticles. A better understanding and controllability of plasmonic electrochromism provides new insights into and means of the connection between photoelectrochemistry and plasmonics as well as future directions for producing advanced optoelectronic materials and devices.
- Published
- 2021
22. Single‐Particle Analysis on Plasmonic Nanogap Systems for Quantitative SERS
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Kyunjong Sim, Seungsang Cha, Ji Yeon Kim, Jeong-Wook Oh, and Jwa-Min Nam
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symbols.namesake ,Materials science ,business.industry ,symbols ,Optoelectronics ,Single particle analysis ,General Materials Science ,Raman spectroscopy ,business ,Spectroscopy ,Plasmon - Published
- 2020
23. Plasmon-Enhanced Spectroscopy
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Minji Ha, Jeong-Wook Oh, Jae-Ho Kim, Minho Kim, Jae-Ho Hwang, Jiwoong Son, and Jwa-Min Nam
- Published
- 2022
24. DNA Nanotechnology for Plasmonics
- Author
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Minji Ha, Jae-Ho Kim, Qian Li, Chunhai Fan, and Jwa-Min Nam
- Published
- 2022
25. Ring-in-a-Triangle Nanoframes: Integrating with Intra- and Interhotspots for Highly Amplified Near-Field Focusing
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Sungeun Go, Sungjae Yoo, Jiwoong Son, Soohyun Lee, Jaewon Lee, Sungwoo Lee, Jeongwon Kim, Minsun Park, Woocheol Park, Jae-Myoung Kim, Jwa-Min Nam, and Sungho Park
- Subjects
Mechanical Engineering ,Metal Nanoparticles ,General Materials Science ,Bioengineering ,General Chemistry ,Gold ,Condensed Matter Physics ,Spectrum Analysis, Raman - Abstract
The development of a stepwise synthetic strategy for Au ring-in-a-triangle nanoframes with a high degree of structural solidity is essential to the advancement of highly amplified near-field focusing. This strategy leads to the formation of an inscribed nanoring in a triangular metal frame with stability to withstand elevated temperatures and an oxidizing environment, which is critical for successful single-particle surface-enhanced Raman scattering (SERS). The existence of inscribed nanorings plays an important role in enhancing the so-called "lightning rod effect," whereby the electromagnetic near-field enhancement occurs on the highly curved curvature of a metallic interface. We evaluated the corresponding single-particle SERS as a function of the thickness of the rims and then constructed two-dimensional (2D) bulk SERS substrates, wherein an ensemble of hotspots exists. The synergic contribution from both inter- and intrahotspots allowed the outstanding linearity of the calibration curve and the lowest limit of detection, ∼10
- Published
- 2022
26. Cyclodextrin-Based Synthesis and Host–Guest Chemistry of Plasmonic Nanogap Particles with Strong, Quantitative, and Highly Multiplexable Surface-Enhanced Raman Scattering Signals
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Jae-Myoung Kim, Ji Yeon Kim, Jwa-Min Nam, and Minji Ha
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chemistry.chemical_classification ,Range (particle radiation) ,Materials science ,Cyclodextrin ,business.industry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Signal ,0104 chemical sciences ,symbols.namesake ,chemistry ,Yield (chemistry) ,symbols ,Optoelectronics ,General Materials Science ,Physical and Theoretical Chemistry ,0210 nano-technology ,Host–guest chemistry ,Raman spectroscopy ,business ,Raman scattering ,Plasmon - Abstract
We developed a synthetic strategy to form cyclodextrin-based intrananogap particles (CIPs) with a well-defined ∼1 nm interior gap in a high yield (∼97%), and were able to incorporate 10 different Raman dyes inside the gap using the cyclodextrin-based host-guest chemistry, leading to strong, reproducible, and highly multiplexable surface-enhanced Raman scattering (SERS) signals. The average SERS enhancement factor (EF) for CIPs was 3.0 × 109 with a very narrow distribution of the EFs that range from 9.5 × 108 to 9.5 × 109 for ∼95% of the measured particles. Remarkably, 10 different Raman dyes can be loaded within the nanogap of CIPs, and 6 different Raman dye-loaded CIPs with little spectral overlaps were distinctly detected for cancer cell imaging applications with a single excitation source. Our synthetic strategy provides new platforms in precisely forming plasmonic nanogap structures with all key features for widespread use of SERS including strong signal intensity, reliability in quantification of signal and multiplexing capability.
- Published
- 2020
27. Synthesis and Surface Plasmonic Characterization of Asymmetric Au Split Nanorings
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Jeongwon Kim, Hyeon Seok Jeong, Jae-Myoung Kim, Jiwoong Son, Jwa-Min Nam, MohammadNavid Haddadnezhad, Sungho Park, Doo Jae Park, and Sungjae Yoo
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Surface (mathematics) ,Plasmonic nanoparticles ,Materials science ,Mechanical Engineering ,Bioengineering ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Surface-enhanced Raman spectroscopy ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Characterization (materials science) ,General Materials Science ,0210 nano-technology ,Plasmon - Abstract
In this Letter, a rational and stepwise method for the solution-phase synthesis of asymmetric Au split nanorings by adopting Au nanoprisms as a template has been demonstrated. The selective chemical etching of Au nanoprism tips activated the surface reactivity of edges and led to the selective deposition of Pt at the periphery of Au nanoplates. By controlling the total amount of Pt on the edges, different degrees of split Au@Pt nanorings were obtained; the subsequent Au coating around the Au@Pt scaffold eventually resulted in asymmetric Au hexagonal split nanorings. Their surface plasmonic features as a function of split degrees were investigated, including straight nanorods, bent nanorods, split nanorings, and full nanorings. The electrical field focusing using single-particle surface-enhanced Raman spectroscopy was evaluated under different polarization angles of the incident light for two different structures with the point gap and line gap between two arms.
- Published
- 2020
28. Silver Double Nanorings with Circular Hot Zone
- Author
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Jae-Myoung Kim, MohammadNavid Haddadnezhad, Junghwa Lee, Sungho Park, Doo Jae Park, Jwa-Min Nam, Jeongwon Kim, Sungwoo Choi, Sungwoo Lee, and Sungjae Yoo
- Subjects
Electromagnetic field ,Detection limit ,Chemistry ,Surface plasmon ,chemistry.chemical_element ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Molecular physics ,Catalysis ,0104 chemical sciences ,symbols.namesake ,Colloid and Surface Chemistry ,Homogeneity (physics) ,symbols ,Molecule ,Halo ,Platinum ,Raman scattering - Abstract
Silver double nanorings with circular intra-nanogaps between two nanorings of different diameters were synthesized without a linker molecule to confine an incident electromagnetic field in a single entity. We used on-demand, rational, and systematic multi-stepwise reactions consisting of (1) selective etching of gold, (2) rim-on deposition of platinum, (3) eccentric growth of gold, and (4) concentric growth of silver. The resulting silver double nanorings exhibited a high degree of homogeneity in both shape and size, with strongly coupled circular hot zones (or "hot halos", referring to the circular intra-nanogaps capable of focusing the near electromagnetic field) resulting from strong surface plasmon coupling between the inner and outer nanorings. Remarkably, these silver double nanorings exhibited strong, stable, and reproducible single-particle surface-enhanced Raman scattering signals without blinking. The signals appeared independently of polarization directions, which is a unique feature of a circular hot halo. The estimated enhancement factor was between 2 × 108 and 7 × 108. The measured limit of detection was 10-7 M in bulk concentration, and the signal appeared 570 s after sample exposure.
- Published
- 2020
29. Synthesis and Single-Particle Surface-Enhanced Raman Scattering Study of Plasmonic Tripod Nanoframes with Y-Shaped Hot-Zones
- Author
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Juri Kim, So Jung Park, Jeongwon Kim, Jwa-Min Nam, Sungwoo Choi, Jae Myoung Kim, Sungho Park, Doo Jae Park, and Sungjae Yoo
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Materials science ,business.industry ,Mechanical Engineering ,Tripod (photography) ,Bioengineering ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Metal ,symbols.namesake ,visual_art ,Electric field ,visual_art.visual_art_medium ,symbols ,Optoelectronics ,General Materials Science ,0210 nano-technology ,business ,Raman spectroscopy ,Plasmon ,Raman scattering - Abstract
Herein, plasmonic metal tripod nanoframes with three-fold symmetry were synthesized in a high yield (∼83%), and their electric field distribution and single-particle surface-enhanced Raman scattering (SERS) were studied. We realized such complex frame morphology by synthesizing analogous tripod nanoframes through multiple transformations. The precise control of the Au growth pattern led to uniform tripod nanoframes embedded with circle or line-shaped hot spots. The linear-shaped nanogaps ("Y"-shaped hot-zone) of the frame structures can strongly and efficiently confine the electric field, allowing for strong SERS signals. Coupled with a high synthetic yield of the targeted frame structure, strong and uniform SERS signals were obtained inside the nanoframe gaps. Remarkably, quite reproducible SERS signals were obtained with these structures-the SERS enhancement factors with an average value of 7.9 × 10
- Published
- 2020
30. A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain
- Author
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He Tian, Limin Pan, Taeghwan Hyeon, Giho Ko, Fangyuan Li, Fan Fei, Dokyoon Kim, Yang Du, Yi Wang, Daishun Ling, Cenglin Xu, Jwa-Min Nam, Wei Guo, Sung Soo Jang, Yanrong Zheng, Jianan Liu, Yingwei Xu, Peihua Lin, Hongwei Liao, Bo Zhang, Zhong Chen, Kwangsoo Shin, Hee Jung Chung, and Qi Wang
- Subjects
Male ,Potassium ,Sodium ,Biomedical Engineering ,Hippocampus ,chemistry.chemical_element ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Membrane Potentials ,Rats, Sprague-Dawley ,Alzheimer Disease ,Seizures ,Nanosensor ,Animals ,Humans ,Premovement neuronal activity ,General Materials Science ,Extracellular potassium ,Electrical and Electronic Engineering ,Membrane potential ,Chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Rats ,0104 chemical sciences ,HEK293 Cells ,Membrane ,Biophysics ,Nanoparticles ,0210 nano-technology - Abstract
Extracellular potassium concentration affects the membrane potential of neurons, and, thus, neuronal activity. Indeed, alterations of potassium levels can be related to neurological disorders, such as epilepsy and Alzheimer's disease, and, therefore, selectively detecting extracellular potassium would allow the monitoring of disease. However, currently available optical reporters are not capable of detecting small changes in potassium, in particular, in freely moving animals. Furthermore, they are susceptible to interference from sodium ions. Here, we report a highly sensitive and specific potassium nanosensor that can monitor potassium changes in the brain of freely moving mice undergoing epileptic seizures. An optical potassium indicator is embedded in mesoporous silica nanoparticles, which are shielded by an ultrathin layer of a potassium-permeable membrane, which prevents diffusion of other cations and allows the specific capturing of potassium ions. The shielded nanosensor enables the spatial mapping of potassium ion release in the hippocampus of freely moving mice.
- Published
- 2020
31. Polysorbate- and DNA-Mediated Synthesis and Strong, Stable, and Tunable Near-Infrared Photoluminescence of Plasmonic Long-Body Nanosnowmen
- Author
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Jwa-Min Nam, Ji Yeon Kim, Jae-Myoung Kim, Minji Ha, and Jeong-Wook Oh
- Subjects
Photoluminescence ,Materials science ,Nanotubes ,business.industry ,Near-infrared spectroscopy ,General Engineering ,General Physics and Astronomy ,Metal Nanoparticles ,Polysorbates ,Surface Plasmon Resonance ,Photobleaching ,Fluorescence ,Light scattering ,Optoelectronics ,General Materials Science ,Nanorod ,Gold ,Surface plasmon resonance ,business ,Plasmon - Abstract
Direct photoluminescence (PL) from metal nanoparticles (NPs) without chemical dyes is promising for sensing and imaging applications since this offers a highly tunable platform for controlling and enhancing the signals in various conditions and does not suffer from photobleaching or photoblinking. It is, however, difficult to synthesize metal NPs with a high quantum yield (QY), particularly in the near-infrared (NIR) region where deep penetration and reduced light scattering are advantageous for bioimaging. Herein, we designed and synthesized Au-Ag long-body nanosnowman structures (LNSs), facilitated by polysorbate 20 (Tween 20). The DNA-engineered conductive junction between the head and body parts results in a charge transfer plasmon (CTP) mode in the NIR region. The junction morphology can be controlled by the DNA sequence on the Au core, and polythymine and polyadenine induced thick and thin junctions, respectively. We found that the LNSs with a thicker conductive junction generates the stronger CTP peak and PL signal than the LNSs with a thinner junction. The Au-Ag LNSs showed much higher intensities in both PL and QY than widely studied Au nanorods with similar localized surface plasmon resonance wavelengths, and notably, the LNSs displayed high photostability and robust, sustainable PL signals under continuous laser exposure for >15 h. Moreover, the PL emission from Au-Ag LNSs could be imaged in a deeper scattering medium than fluorescent silica NPs. Finally, highly robust PL-based cell images can be obtained using Au-Ag LNSs without significant signal change while repetitively imaging cells. The results offer the insights in plasmonic NIR probe design, and show that chemical dye-free LNSs can be a very promising candidate with a high QY and a robust, reliable NIR PL signal for NIR sensing and imaging applications.
- Published
- 2021
32. Synthesis of morphology controlled PtAu@Ag nanorings through concentric and eccentric growth pathways
- Author
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Sungeun Go, Jiwoong Son, Sungho Park, Jae-Won Lee, Sungjae Yoo, Soo Hyun Lee, Jwa-Min Nam, Jeongwon Kim, Hajir Hilal, Sungwoo Lee, and Junghwa Lee
- Subjects
Morphology (linguistics) ,Materials science ,Metals and Alloys ,Halide ,General Chemistry ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,symbols.namesake ,Adsorption ,Chemical engineering ,Monolayer ,Materials Chemistry ,Ceramics and Composites ,symbols ,Surface plasmon resonance ,Raman spectroscopy ,Nanoring ,Electrochemical potential - Abstract
We report the synthetic methodology for silver nanorings with controlled nanoscale morphology. The morphology of Ag nanorings was kinetically controlled by electrochemical potential tuning of Ag deposition using halide counter-ions, which resulted in concentric PtAu@Ag nanorings (i.e., Ag homogeneously wrapped around the Pt nanorings) and eccentric PtAu@Ag nanorings (i.e., Ag selectively deposited at the inner boundary of the Pt nanorings). The resulting high quality of each Ag nanoring allowed us to systematically investigate their corresponding localized surface plasmon resonance (LSPR) profiles as a function of their geometrical parameters. Additionally, we evaluated the application of the samples as surface-enhanced Raman spectroscopy (SERS) substrates composed of 2D monolayers of varied compositions of Ag and Au nanorings, which showed a different extent of enhancement depending on the adsorption characteristics of the analytes.
- Published
- 2021
33. World Scientific Reference on Plasmonic Nanomaterials
- Author
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Luis M Liz-Marzán, Jwa-Min Nam, Jianfang Wang, Zhihong Nie, Kimberly Hamad-Schifferli, and Sebastian Schlücker
- Published
- 2021
34. World Scientific Reference on Plasmonic Nanomaterials
- Author
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Kimberly Hamad-Schifferli, Sebastian Schlücker, Jianfang Wang, Zhihong Nie, Jwa-Min Nam, and Luis M Liz-Marzán
- Subjects
Materials science ,Nanoparticle ,Nanotechnology ,Plasmon ,Nanomaterials - Published
- 2021
35. World Scientific Reference on Plasmonic Nanomaterials
- Author
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Jianfang Wang, Jwa-Min Nam, Kimberly Hamad-Schifferli, Zhihong Nie, Sebastian Schlücker, and Luis M Liz-Marzán
- Subjects
Materials science ,Nanotechnology ,Self-assembly ,Plasmonic nanostructures ,Plasmon ,Nanomaterials - Published
- 2021
36. World Scientific Reference on Plasmonic Nanomaterials
- Author
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Zhihong Nie, Luis M Liz-Marzán, Sebastian Schlücker, Jwa-Min Nam, Jianfang Wang, and Kimberly Hamad-Schifferli
- Subjects
Engineering ,business.industry ,Nanotechnology ,business ,Plasmon ,Nanomaterials - Published
- 2021
37. Au Nanorings with Intertwined Triple Rings
- Author
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Hajir Hilal, Jae-Myoung Kim, Jeongwon Kim, Jiwoong Son, Soo Hyun Lee, Sungeun Go, MohammadNavid Haddadnezhad, Jwa-Min Nam, Sungho Park, and Sungjae Yoo
- Subjects
Chemistry ,Nanoparticle ,General Chemistry ,Biochemistry ,Isotropic etching ,Catalysis ,symbols.namesake ,Colloid and Surface Chemistry ,Chemical physics ,Homogeneity (physics) ,symbols ,Molecule ,Surface plasmon resonance ,Nanoscopic scale ,Raman scattering ,Nanoring - Abstract
We designed complex Au nanorings with intertwined triple rings (ANITs) in a single entity to amplify the efficacy of near-field focusing. Such a complex and unprecedented morphology at the nanoscale was realized through on-demand multistepwise reactions. Triangular nanoprisms were first sculpted into circular nanorings, followed by a series of chemical etching and deposition reactions eventually leading to ANITs wherein thin metal bridges hold the structure together without any linker molecules. In the multistepwise reaction, the well-faceted growth pattern of Au, which induces the growth of two distinctive flat facets in a lateral direction, is important to evolve the morphology from single to multiple nanorings. Although our synthesis proceeds through multiple steps in one batch without purification steps, it shows a remarkably high yield (>∼90%) at the final stage. The obtained high degree of homogeneity (in both shape and size) of the resulting ANITs allowed us to systematically investigate the corresponding localized surface plasmon resonance (LSPR) coupling with varying nanoring arrangements and observe their single-particle surface enhanced Raman scattering (SERS). Surprisingly, individual ANITs exhibited an enormously large enhancement factor (∼109), which confirms their superior near-field focusing relative to other reported nanoparticles.
- Published
- 2021
38. Plasmonic Nanoparticle-Interfaced Lipid Bilayer Membranes
- Author
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Sungi Kim, Jwa-Min Nam, Jeong-Wook Oh, Namjun Kim, Jinyoung Seo, and Ha H. Park
- Subjects
chemistry.chemical_classification ,Plasmonic nanoparticles ,Materials science ,010405 organic chemistry ,Bilayer ,Biomolecule ,Cell Membrane ,Lipid Bilayers ,Nanoparticle ,Nanotechnology ,General Medicine ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Membrane ,chemistry ,Biomimetic Materials ,Nanoparticles ,Nanobiotechnology ,Lipid bilayer ,Biosensor - Abstract
Plasmonic nanoparticles are widely exploited in diverse bioapplications ranging from therapeutics to biosensing and biocomputing because of their strong and tunable light-matter interactions, facile and versatile chemical/biological ligand modifications, and biocompatibility. With the rapid growth of nanobiotechnology, understanding dynamic interactions between nanoparticles and biological systems at the molecular or single-particle level is becoming increasingly important for interrogating biological systems with functional nanostructures and for developing nanoparticle-based biosensors and therapeutic agents. Therefore, significant efforts have been devoted to precisely design and create nano-bio interfaces by manipulating the nanoparticles' size, shape, and surface ligand interactions with complex biological systems to maximize their performance and avoid unwanted responses, such as their agglomeration and cytotoxicity. However, investigating physicochemical interactions at the nano-bio interfaces in a quantitative and controllable manner remains challenging, as the interfaces involve highly complex networks between nanoparticles, biomolecules, and cells across multiple scales, each with a myriad of different chemical and biological interactions. A lipid bilayer is a membrane made of two layers of lipid molecules that forms a barrier around cells and plays structural and functional roles in diverse biological processes because they incorporate and present functional molecules (such as membrane proteins) with lateral fluidity. Plasmonic nanoparticles conjugated on lipid membranes provide reliable analytical labels and functional moieties that allow for studying and manipulating interactions between nanoparticles and molecules with single-particle resolution; they also serve as efficient tools for applying optical, mechanical, and thermal stimuli to biological systems, which stem from plasmonic properties. Recently, new opportunities have emerged by interfacing nanoparticle-modified lipid bilayers (NLBs) with complex systems such as molecular circuits and living systems. In this Account, we briefly review how plasmonic properties can be beneficially harnessed on lipid bilayer membranes to investigate the structures and functions of cellular membranes and to develop new platforms for biomedical applications. In particular, we discuss the versatility of supported lipid bilayers (SLBs), which are planar lipid bilayers on hydrophilic substrates, as dynamic biomaterials that provide lateral fluidity and cell membrane-like environments. We then summarize our efforts to create a quantitative analytical platform utilizing nanoparticles as active building blocks and SLBs as integrative substrates. Through this bottom-up approach, various functionalized nanoparticles have been introduced onto lipid bilayers to render nanoparticle-nanoparticle, nanoparticle-lipid bilayer, and biomolecule-lipid bilayer interfaces programmable. Our system provides a new class of tools for studying thermodynamics and kinetics in complex networks of nanostructures and for realizing unique applications in biosensing and biocomputing.
- Published
- 2019
39. Statistical Modeling of Ligand-Mediated Multimeric Nanoparticle Assembly
- Author
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Jwa-Min Nam, Jinsoo Oh, Hohsuk Noh, Jung-Hoon Lee, Han Choe, Gyeong-Hwan Kim, Jeong-Wook Oh, and Mouhong Lin
- Subjects
Chemistry ,Nanoparticle ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Ligand (biochemistry) ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,General Energy ,Nanobiotechnology ,Physical and Theoretical Chemistry ,0210 nano-technology - Abstract
Understanding and controlling nanoparticle (NP) assembly have tremendous importance and impact in nanoscience, materials science, physical sciences, and nanobiotechnology. Although NP assembly has ...
- Published
- 2019
40. Metal alloy hybrid nanoparticles with enhanced catalytic activities in fuel cell applications
- Author
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Minho Kim, Sung Min Ko, Chungyeon Lee, and Jwa-Min Nam
- Subjects
Materials science ,Nanoparticle ,chemistry.chemical_element ,Nanotechnology ,Environmental pollution ,02 engineering and technology ,010402 general chemistry ,Electrocatalyst ,Electrochemistry ,01 natural sciences ,Catalysis ,Inorganic Chemistry ,Materials Chemistry ,Physical and Theoretical Chemistry ,business.industry ,Fossil fuel ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Nanomaterial-based catalyst ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,chemistry ,Ceramics and Composites ,0210 nano-technology ,business ,Platinum - Abstract
Due to the depletion of fossil fuels and severe environmental pollution problems, the urgent demand for clean and sustainable energy sources is constantly emphasized. In recent decades, platinum (Pt)-based fuel cells have achieved tremendous advances as a green energy source, but there is still a need to further improve energy production efficiency in order to realize practical applications. Conventional Pt electrocatalysts are usually insufficient in catalytic activity and the selectivity of electrochemical reactions due to sluggish kinetics and surface poisoning. In contrast, metal alloy nanocatalysts exhibit exceptional electrocatalytic performance on fuel cells, more than pure Pt catalysts, owing to the synergistic effect by systematic modification of the surface geometry and electronic structure of the catalytically active metal component. This review provides overviews and advances in the applications of metal alloy nanohybrid particles enabling the improvement of electrocatalytic efficiency and discusses the challenges and outlooks in the fields of green energy production based on metal alloy nanocatalysts.
- Published
- 2019
41. Surface-enhanced Raman scattering-based detection of hazardous chemicals in various phases and matrices with plasmonic nanostructures
- Author
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Jeong-Wook Oh, Jaewon Choi, Jae-Ho Kim, and Jwa-Min Nam
- Subjects
Analyte ,Materials science ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Photobleaching ,Signal ,0104 chemical sciences ,symbols.namesake ,Hazardous waste ,Chemical specificity ,symbols ,General Materials Science ,0210 nano-technology ,Raman spectroscopy ,Plasmon ,Raman scattering - Abstract
Surface-enhanced Raman scattering (SERS)-based sensors utilize the electromagnetic-field enhancement of plasmonic substrates with the chemical specificity of vibrational Raman spectroscopy to identify trace amounts of a wide variety of different target analytes while being minimally affected by photobleaching. However, despite many advantageous features of this method, SERS sensors, particularly for detecting hazardous chemicals, suffer from several limitations such as requirement of gigantic signal enhancement that is often poorly controllable, subtle change and degradation of the SERS substrate, consecutive fluctuation of the signal, the lack of reliable receptors for capturing targets of interest and the absence of general principles for detecting various chemicals in different phases and matrices. To overcome these limitations and for SERS sensors to find practical use, one must (1) acknowledge the characteristics of the matrices of target systems, (2) finely engineer and tune the receptors of the SERS sensor to properly extract the target analyte from the phase, and (3) implement additional mechanistic modifications to enhance the plasmonic signal. This minireview underlines the difficulties associated with different phases and a wide range of target analytes, and introduces the practical measures undertaken to overcome the respective difficulties in SERS-based detection of hazardous chemicals.
- Published
- 2019
42. Plasmonic colloidosomes of black gold for solar energy harvesting and hotspots directed catalysis for CO2 to fuel conversion
- Author
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Bhagyashree A. Chalke, Anirban Das, Mahak Dhiman, Ayan Maity, Yeon-Hee Lee, Kyunjong Sim, Jwa-Min Nam, Vivek Polshettiwar, and Rajesh Belgamwar
- Subjects
Materials science ,Atmospheric pressure ,010405 organic chemistry ,business.industry ,Electron energy loss spectroscopy ,Physics::Optics ,General Chemistry ,010402 general chemistry ,Solar energy ,01 natural sciences ,Methane ,0104 chemical sciences ,Catalysis ,symbols.namesake ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Colloidal gold ,symbols ,Physics::Chemical Physics ,business ,Raman spectroscopy ,Plasmon - Abstract
In this work, we showed the tuning of the catalytic behavior of dendritic plasmonic colloidosomes (DPCs) by plasmonic hotspots. A cycle-by-cycle solution-phase synthetic protocol yielded high-surface-area DPCs by controlled nucleation–growth of gold nanoparticles. These DPCs, which had varying interparticle distances and particle-size distribution, absorb light over the entire visible region as well as in the near-infrared region of the solar spectrum, transforming gold into black gold. They produced intense hotspots of localized electric fields as well as heat, which were quantified and visualized by Raman thermometry and electron energy loss spectroscopy plasmon mapping. These DPCs can be effectively utilized for the oxidation reaction of cinnamyl alcohol using pure oxygen as the oxidant, hydrosilylation of aldehydes, temperature jump assisted protein unfolding and purification of seawater to drinkable water via steam generation. Black gold DPCs also convert CO2 to methane (fuel) at atmospheric pressure and temperature, using solar energy.
- Published
- 2019
43. DNA-Engineerable Ultraflat-Faceted Core-Shell Nanocuboids with Strong, Quantitative Plasmon-Enhanced Fluorescence Signals for Sensitive, Reliable MicroRNA Detection
- Author
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Jiwoong Son, Jwa-Min Nam, Jae-Ho Hwang, Soohyun Park, and Joon Won Park
- Subjects
Materials science ,Dynamic range ,Mechanical Engineering ,Nanoparticle ,Bioengineering ,Nanotechnology ,02 engineering and technology ,General Chemistry ,DNA ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Silicon Dioxide ,Fluorescence ,Core shell ,chemistry.chemical_compound ,MicroRNAs ,Spectrometry, Fluorescence ,chemistry ,General Materials Science ,Nanorod ,0210 nano-technology ,Biosensor ,Plasmon ,Fluorescent Dyes - Abstract
There has been enormous interest in understanding and utilizing plasmon-enhanced fluorescence (PEF) with metal nanostructures, but maximizing the enhancement in a reproducible, quantitative manner while reliably controlling the distance between dyes and metal particle surface for practical applications is highly challenging. Here, we designed and synthesized fluorescence-amplified nanocuboids (FANCs) with highly enhanced and controlled PEF signals, and fluorescent silica shell-coated FANCs (FS-FANCs) were then formed to fixate the dye position and increase particle stability and fluorescence signal intensity for biosensing applications. By uniformly modifying fluorescently labeled DNA on Au nanorods and forming ultraflat Ag shells on them, we were able to reliably control the distance between fluorophores and Ag surface and obtained an ∼186 fluorescence enhancement factor with these FANCs. Importantly, FS-FANCs were utilized as fluorescent nanoparticle tags for microarray-based miRNA detection, and we achieved >103-fold higher sensitivity than commercially available chemical fluorophores with 100 aM to 1 pM dynamic range.
- Published
- 2021
44. One-Pot Heterointerfacial Metamorphosis for Synthesis and Control of Widely Varying Heterostructured Nanoparticles
- Author
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Jianan Liu, Yoonjae Jung, Gyeong-Hwan Kim, Youngju Son, Jian Wang, Jeong-Wook Oh, Limin Pan, Sungjae Seo, Taeghwan Hyeon, Jungwon Park, Jwa-Min Nam, Mouhong Lin, Jongwoo Lim, and Yeon-Hee Lee
- Subjects
Colloid and Surface Chemistry ,Chemistry ,media_common.quotation_subject ,Nanoparticle ,Nanotechnology ,General Chemistry ,Metamorphosis ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Catalysis ,0104 chemical sciences ,media_common - Abstract
Despite remarkable facileness and potential in forming a wide variety of heterostructured nanoparticles with extraordinary compositional and structural complexity, one-pot synthesis of multicomponent heterostructures is largely limited by the lack of fundamental mechanistic understanding, designing principles, and well-established, generally applicable chemical methods. Herein, we developed a one-pot heterointerfacial metamorphosis (1HIM) method that allows heterointerfaces inside a particle to undergo multiple equilibrium stages to form a variety of highly crystalline heterostructured nanoparticles at a relatively low temperature (100 °C). As proof-of-concept experiments, it was shown that widely different single-crystalline semiconductor-metal anisotropic nanoparticles with synergistic chemical, spectroscopic, and band-gap-engineering properties, including a series of metal-semiconductor nanoframes with high structural and compositional tunability, can be formed by using the 1HIM approach. 1HIM offers a new paradigm to synthesize previously unobtainable or poorly controllable heterostructures with unique or synergistic properties and functions.
- Published
- 2021
45. Quantitative, scalable surface-enhanced Raman scattering nanoprobes for biodiagnostic applications
- Author
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Jwa-Min Nam
- Abstract
Designing, synthesizing and controlling plasmonic metal nanostructures with high precision and high yield are of paramount importance in optics, nanoscience, chemistry, materials science, energy and biotechnology.
- Published
- 2021
46. Controlled Assembly of Plasmonic Nanoparticles: From Static to Dynamic Nanostructures
- Author
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Jwa-Min Nam, So Jung Park, So Yoon Moon, Kyunjong Sim, Sunghee Lee, Jisu Choi, and Yoojung Jeon
- Subjects
Plasmonic nanoparticles ,Nanostructure ,Materials science ,Mechanical Engineering ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Mechanics of Materials ,Assembly structure ,General Materials Science ,Collective property ,0210 nano-technology ,Metal nanoparticles ,Plasmon - Abstract
The spatial arrangement of plasmonic nanoparticles can dramatically affect their interaction with electromagnetic waves, which offers an effective approach to systematically control their optical properties and manifest new phenomena. To this end, significant efforts were made to develop methodologies by which the assembly structure of metal nanoparticles can be controlled with high precision. Herein, recent advances in bottom-up chemical strategies toward the well-controlled assembly of plasmonic nanoparticles, including multicomponent and multifunctional systems are reviewed. Further, it is discussed how the progress in this area has paved the way toward the construction of smart dynamic nanostructures capable of on-demand, reversible structural changes that alter their properties in a predictable and reproducible manner. Finally, this review provides insight into the challenges, future directions, and perspectives in the field of controlled plasmonic assemblies.
- Published
- 2020
47. Highly Efficient Photothermal Therapy with Cell-Penetrating Peptide-Modified Bumpy Au Triangular Nanoprisms using Low Laser Power and Low Probe Dose
- Author
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Yan Lee, Yuna Kim, Jwa-Min Nam, Seung-Eun Chong, Kyunjong Sim, Ji Yeon Kim, So Hee Nam, and Minji Ha
- Subjects
Materials science ,Photothermal Therapy ,Bioengineering ,02 engineering and technology ,Cell-Penetrating Peptides ,law.invention ,Nanomaterials ,Mice ,law ,In vivo ,Cell Line, Tumor ,Animals ,General Materials Science ,Laser power scaling ,Irradiation ,Mechanical Engineering ,Lasers ,General Chemistry ,Penetration (firestop) ,Hyperthermia, Induced ,Photothermal therapy ,Phototherapy ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Laser ,Nanostructures ,Cell-penetrating peptide ,Biophysics ,Gold ,0210 nano-technology - Abstract
Photothermal therapy (PTT) exploits nanomaterials with optimal heat conversion and cellular penetration using near-infrared (NIR) laser irradiation. However, current PTT agents suffer from inefficient heat conversion, poor intracellular delivery, and a high dose of probes along with excessive laser irradiation, causing limited therapeutic outcomes. Here, bumpy Au triangular nanoprisms (BATrisms) are developed for increasing the surface area, improving cell penetration, shifting the absorption peak to the NIR region, and enhancing the photothermal conversion efficiency (∼86%). Further, leucine (L)- and lysine (K)-rich cell-penetrating peptides (LK peptides) were employed to largely improve their cellular uptake efficiency. Importantly, a significant in vivo therapeutic efficacy with LK-BATrisms was demonstrated in a triple-negative breast cancer xenograft mice model. A very small dose of LK-BATrism (2.5 μg Au) was enough to exert antitumor efficacy under very low laser power (808 nm, 0.25 W/cm2), causing minimal tissue damages while very efficiently killing cancer cells.
- Published
- 2020
48. Metal Nanostructures with Plasmonically Enhanced Raman and Photoluminescence Signals
- Author
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Minho Kim, Jiwoong Son, Jeong-Eun Park, Chungyeon Lee, Jwa-Min Nam, and Sung Min Ko
- Subjects
symbols.namesake ,Materials science ,Photoluminescence ,business.industry ,symbols ,Optoelectronics ,Metal nanostructures ,business ,Raman spectroscopy - Published
- 2020
49. Multiplex SNP Genotyping Using SWITCH: Sequence‐Specific Nanoparticle with Interpretative Toehold‐Mediated Sequence Decoding in Hydrogel (Small 8/2022)
- Author
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Woongsun Choi, Eunhye Park, Seojin Bae, Kyung‐Hak Choi, Sangeun Han, Kuk‐Hui Son, Do Young Lee, Il‐Joo Cho, Hyejeong Seong, Kyo Seon Hwang, Jwa‐Min Nam, Jungkyu Choi, Hyojin Lee, and Nakwon Choi
- Subjects
Biomaterials ,General Materials Science ,General Chemistry ,Biotechnology - Published
- 2022
50. Nanoparticle-based computing architecture for nanoparticle neural networks
- Author
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Jinyoung Seo, Ji-Eun Kim, Jwa-Min Nam, Ha H. Park, Jeong-Eun Park, Sungi Kim, Seungsang Cha, Namjun Kim, Eun-Ho Song, and So Young Choi
- Subjects
Computer science ,Physics::Medical Physics ,Physics::Optics ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Quantitative Biology::Subcellular Processes ,Computer Science::Hardware Architecture ,symbols.namesake ,Printed circuit board ,Software ,Research Articles ,Quantitative Biology::Biomolecules ,Multidisciplinary ,Artificial neural network ,business.industry ,SciAdv r-articles ,021001 nanoscience & nanotechnology ,Chip ,Perceptron ,0104 chemical sciences ,ComputingMethodologies_PATTERNRECOGNITION ,Applied Sciences and Engineering ,Computer architecture ,Logic gate ,Scalability ,symbols ,0210 nano-technology ,business ,Research Article ,Von Neumann architecture - Abstract
The nanoparticle-based von Neumann architecture is constructed on a lipid chip to execute nanoparticle neural networks with DNA., The lack of a scalable nanoparticle-based computing architecture severely limits the potential and use of nanoparticles for manipulating and processing information with molecular computing schemes. Inspired by the von Neumann architecture (VNA), in which multiple programs can be operated without restructuring the computer, we realized the nanoparticle-based VNA (NVNA) on a lipid chip for multiple executions of arbitrary molecular logic operations in the single chip without refabrication. In this system, nanoparticles on a lipid chip function as the hardware that features memory, processors, and output units, and DNA strands are used as the software to provide molecular instructions for the facile programming of logic circuits. NVNA enables a group of nanoparticles to form a feed-forward neural network, a perceptron, which implements functionally complete Boolean logic operations, and provides a programmable, resettable, scalable computing architecture and circuit board to form nanoparticle neural networks and make logical decisions.
- Published
- 2020
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