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[english] Aim: The in vitro activity of colistin in combination with sulbactam, netilmicin, and vancomycin against colistin-resistant strains was investigated. Furthermore, the clonal relationship of the strains was analyzed. Methods: Clonal relationship was investigated using rep-PCR. To screen for synergysm, the fractional inhibitory concentration index (FICI) was calculated using checkerboard assay. The killing kinetics of the combination of colistin with vancomycin was assessed using time-kill assay. Results: Three different clones were found among 10 clinical isolates of colistin-resistant strains. Thereof, 8 strains were susceptible to netilmicin. Synergistic interaction was detected in 1 strain with the combination of colistin-netilmicin, in 5 strains with colistin-sulbactam, and in 9 strains with colistin-vancomycin. None of combinations had antagonistic activity. Colistin-vancomycin combination resulted in rapid bactericidal activity. Conclusion: These results show a distinct in vitro synergism between colistin and vancomycin, which might be useful to treat infection with multiple-resistant strains, prevent emergence of resistant strains, and to lower doses for both antibiotics to be used.

Leveraging scattering information to describe binary systems in generic orbits requires identifying local and nonlocal in time tail effects. We report here the derivation of the universal (nonspinning) local in time conservative dynamics at fourth post-Minkowskian order, i.e., O(G^{4}). This is achtieved by computing the nonlocal-in-time contribution to the deflection angle, and removing it from the full conservative value in [C. Dlapa et al., Phys. Rev. Lett. 128, 161104 (2022).PRLTAO0031-900710.1103/PhysRevLett.128.161104; C. Dlapa et al., Phys. Rev. Lett. 130, 101401 (2023).PRLTAO0031-900710.1103/PhysRevLett.130.101401]. Unlike the total result, the integration problem involves two scales-velocity and mass ratio-and features multiple polylogarithms, complete elliptic and iterated elliptic integrals, notably in the mass ratio. We reconstruct the local radial action, center-of-mass momentum and Hamiltonian, as well as the exact logarithmic-dependent part(s), all valid for generic orbits. We incorporate the remaining nonlocal terms for ellipticlike motion to sixth post-Newtonian order. The combined Hamiltonian is in perfect agreement in the overlap with the post-Newtonian state of the art. The results presented here provide the most accurate description of gravitationally bound binaries harnessing scattering data to date, readily applicable to waveform modeling.

We obtain the total impulse in the scattering of nonspinning binaries in general relativity at fourth post-Minkowskian order, i.e., O(G^{4}), including linear, nonlinear, and hereditary radiation-reaction effects. We derive the total radiated spacetime momentum as well as the associated energy flux. The latter can be used to compute gravitational-wave observables for generic (un)bound orbits. We employ the ("in-in") Schwinger-Keldysh worldline effective field theory framework in combination with modern "multiloop" integration techniques from collider physics. The complete results are in agreement with various partial calculations in the post-Minkowskian and post-Newtonian expansion.

We compute the conservative dynamics of nonspinning binaries at fourth post-Minkowskian order in the large-eccentricity limit, including both potential and radiation-reaction tail effects. This is achieved by obtaining the scattering angle in the worldline effective field theory approach and deriving the bound radial action via analytic continuation. The associated integrals are bootstrapped to all orders in velocities through differential equations, with boundary conditions in the potential and radiation regions. The large angular momentum expansion captures all the local-in-time effects as well as the trademark logarithmic corrections for generic bound orbits. Agreement is found in the overlap with the state of the art in post-Newtonian theory.

We derive the conservative dynamics of nonspinning binaries to third post-Minkowskian order, using the effective field theory (EFT) approach introduced in [G. Kälin and R. A. Porto, J. High Energy Phys. 11 (2020) 106JHEPFG1029-847910.1007/JHEP11(2020)106] together with the boundary-to-bound dictionary developed in [G. Kälin and R. A. Porto, J. High Energy Phys. 01 (2020) 072JHEPFG1029-847910.1007/JHEP01(2020)072; J. High Energy Phys. 02 (2020) 120.JHEPFG1029-847910.1007/JHEP02(2020)120]. The main ingredient is the scattering angle, which we compute to O(G^{3}) via Feynman diagrams. Adapting to the EFT framework powerful tools from the amplitudes program, we show how the associated (master) integrals are bootstrapped to all orders in velocities via differential equations. Remarkably, the boundary conditions can be reduced to the same integrals that appear in the EFT with post-Newtonian sources. For the sake of comparison, we reconstruct the Hamiltonian and the classical limit of the scattering amplitude. Our results are in perfect agreement with those in Bern et al. [Phys. Rev. Lett. 122, 201603 (2019)PRLTAO0031-900710.1103/PhysRevLett.122.201603; J. High Energy Phys. 10 (2019) 206JHEPFG1029-847910.1007/JHEP10(2019)206].

We present the fully integrated form of the two-loop four-gluon amplitude in N=2 supersymmetric quantum chromodynamics with gauge group SU(N_{c}) and with N_{f} massless supersymmetric quarks (hypermultiplets) in the fundamental representation. Our result maintains full dependence on N_{c} and N_{f}, and relies on the existence of a compact integrand representation that exhibits the duality between color and kinematics. Specializing to the N=2 superconformal theory, where N_{f}=2N_{c}, we obtain remarkably simple amplitudes that have an analytic structure close to that of N=4 super-Yang-Mills theory, except that now certain lower-weight terms appear. We comment on the corresponding results for other gauge groups.

Background: Neuraxial blockade is used as primary anesthetic technique in one third of surgical procedures. The authors tested whether bisoprolol would protect patients at risk for cardiovascular complications undergoing surgery with spinal block., Methods: The authors performed a double-blinded, placebo-controlled, multicenter trial to compare the effect of bisoprolol with that of placebo on 1-yr composite outcome including cardiovascular mortality, nonfatal myocardial infarction, unstable angina, congestive heart failure, and cerebrovascular insult. Bisoprolol was given orally before and after surgery for a maximum of 10 days. Adrenergic receptor polymorphisms and safety outcome measures of bisoprolol therapy were also determined., Results: A total of 224 patients were enrolled. Spinal block could not be established in 5 patients. One hundred ten patients were assigned to the bisoprolol group, and 109 patients were assigned to the placebo group. The mean duration of treatment was 4.9 days in the bisoprolol group and 5.1 days in the placebo group. Bisoprolol therapy reduced mean heart rate by 10 beats/min. The primary outcome was identical between treatment groups and occurred in 25 patients (22.7%) in the bisoprolol group and 24 patients (22.0%) in the placebo group during the 1-yr follow-up (hazard ratio, 0.97; 95% confidence interval, 0.55-1.69; P = 0.90). However, carriers of at least one Gly allele of the beta1-adrenergic receptor polymorphism Arg389Gly showed a higher number of adverse events than Arg homozygous (32.4% vs. 18.7%; hazard ratio, 1.87; 95% confidence interval, 1.04-3.35; P = 0.04)., Conclusions: Perioperative bisoprolol therapy did not affect cardiovascular outcome in these elderly at-risk patients undergoing surgery with spinal block.