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43 results on '"Köhrmann, Kai Uwe"'

2. Late toxicities and recurrences in patients with clinical stage I non-seminomatous germ cell tumours after 1 cycle of adjuvant bleomycin, etoposide and cisplatin versus primary retroperitoneal lymph node dissection – A 13-year follow-up analysis of a phase III trial cohort

Author

Hiester, Andreas, Fingerhut, Anna, Niegisch, Günter, Siener, Roswitha, Krege, Susanne, Schmelz, Hans-Ulrich, Dieckmann, Klaus-Peter, Heidenreich, Axel, Kwasny, Peter, Pechoel, Maik, Lehmann, Jan, Kliesch, Sabine, Köhrmann, Kai-Uwe, Fimmers, Rolf, Loy, Volker, Wittekind, Christian, Hartmann, Michael, and Albers, Peter

Published
2021
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6. European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part II

Author

Krege, Susanne, Beyer, Jörg, Souchon, Rainer, Albers, Peter, Albrecht, Walter, Algaba, Ferran, Bamberg, Michael, Bodrogi, István, Bokemeyer, Carsten, Cavallin-Ståhl, Eva, Classen, Johannes, Clemm, Christoph, Cohn-Cedermark, Gabriella, Culine, Stéphane, Daugaard, Gedske, De Mulder, Pieter H.M., De Santis, Maria, de Wit, Maike, de Wit, Ronald, Derigs, Hans Günter, Dieckmann, Klaus-Peter, Dieing, Annette, Droz, Jean-Pierre, Fenner, Martin, Fizazi, Karim, Flechon, Aude, Fosså, Sophie D., Garcia del Muro, Xavier, Gauler, Thomas, Geczi, Lajos, Gerl, Arthur, Germa-Lluch, Jose Ramon, Gillessen, Silke, Hartmann, Jörg T., Hartmann, Michael, Heidenreich, Axel, Hoeltl, Wolfgang, Horwich, Alan, Huddart, Robert, Jewett, Michael, Joffe, Johnathan, Jones, William G., Kisbenedek, László, Klepp, Olbjørn, Kliesch, Sabine, Koehrmann, Kai Uwe, Kollmannsberger, Christian, Kuczyk, Markus, Laguna, Pilar, Leiva Galvis, Oscar, Loy, Volker, Mason, Malcolm D., Mead, Graham M., Mueller, Rolf, Nichols, Craig, Nicolai, Nicola, Oliver, Tim, Ondrus, Dalibor, Oosterhof, Gosse O.N., Paz-Ares, Luis, Pizzocaro, Giorgio, Pont, Jörg, Pottek, Tobias, Powles, Tom, Rick, Oliver, Rosti, Giovanni, Salvioni, Roberto, Scheiderbauer, Jutta, Schmelz, Hans-Ulrich, Schmidberger, Heinz, Schmoll, Hans-Joachim, Schrader, Mark, Sedlmayer, Felix, Skakkebaek, Niels E., Sohaib, Aslam, Tjulandin, Sergei, Warde, Padraig, Weinknecht, Stefan, Weissbach, Lothar, Wittekind, Christian, Winter, Eva, Wood, Lori, and von der Maase, Hans

Published
2008
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10. Interdisziplinärer Konsensus zur Diagnostik und Therapie von Hodentumoren Ergebnisse einer Update-Konferenz auf Grundlage evidenzbasierter Medizin (EBM): Ergebnisse einer Update-Konferenz auf Grundlage evidenzbasierter Medizin (EBM)

Author

Souchon, Rainer, Krege, Susanne, Schmoll, Hans-Joachim, Albers, Peter, Beyer, Jörg, Bokemeyer, Carsten, Claßen, Johannes, Dieckmann, Klaus-Peter, Hartmann, Michael, Heidenreich, Axel, Höltl, Wolfgang, Kliesch, Sabine, Köhrmann, Kai-Uwe, Kuczyk, Markus, Schmidberger, Heinz, Weinknecht, Stephan, Winter, Eva, Wittekind, Christian, Bamberg, Michael, and für die German Testicular Cancer Study Group (GTCSG)

Published
2000
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20. Therapieerfolg nur durch präzise Tumorlokalisation möglich

Author

Ganzer, Roman, primary, Baumunk, Daniel, additional, Blana, Andreas, additional, Franiel, Tobias, additional, Hadaschik, Boris, additional, Henkel, Thomas, additional, Köhrmann, Kai-Uwe, additional, Köllermann, Jens, additional, Kuru, Timur, additional, Liehr, Uwe-Bernd, additional, Machtens, Stefan, additional, Roosen, Alexander, additional, Salomon, Georg, additional, Schlemmer, Heinz-Peter, additional, Sentker, Ludger, additional, Witzsch, Ulrich, additional, and Schostak, Martin, additional

Published
2016
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21. Randomized Phase III Trial Comparing Retroperitoneal Lymph Node Dissection With One Course of Bleomycin and Etoposide Plus Cisplatin Chemotherapy in the Adjuvant Treatment of Clinical Stage I Nonseminomatous Testicular Germ Cell Tumors: AUO Trial AH 01/94 by the German Testicular Cancer Study Group

Author

Albers, Peter, primary, Siener, Roswitha, additional, Krege, Susanne, additional, Schmelz, Hans-Uwe, additional, Dieckmann, Klaus-Peter, additional, Heidenreich, Axel, additional, Kwasny, Peter, additional, Pechoel, Maik, additional, Lehmann, Jan, additional, Kliesch, Sabine, additional, Köhrmann, Kai-Uwe, additional, Fimmers, Rolf, additional, Weiβbach, Lothar, additional, Loy, Volker, additional, Wittekind, Christian, additional, and Hartmann, Michael, additional

Published
2008
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36. High-Intensity Focused Ultrasound for ex VivoKidney Tissue Ablation: Influence of Generator Power and Pulse Duration

Author

Häcker, Axel, Köhrmann, Kai Uwe, Knoll, Thomas, Langbein, Sigrun, Steidler, Annette, Kraut, Oliver, Marlinghaus, Ernst, Alken, Peter, and Michel, Maurice Stephan

Abstract

Background and Purpose:The therapeutic application of noninvasive tissue ablation by high-intensity focused ultrasound (HIFU) requires precise physical definition of the focal size and determination of control parameters. The objective of this study was to measure the extent of ex-vivoporcine kidney tissue ablation at variable generator parameters and to identify parameters to control lesion size.Materials and Methods:The ultrasound waves generated by a cylindrical piezoceramic element (1.04 MHz) were focused at a depth of 100 mm using a parabolic reflector (diameter 100 mm). A needle hydrophone was used to measure the field distribution of the sound pressure. The morphology and extent of tissue necrosis were examined at generator powers of up to 400 W (Pel) and single pulse durations of as long as 8 seconds.Results:The two-dimensional field distribution resulted in an approximately ellipsoidal focus of 32 × 4 mm (–6 dB). A sharp demarcation between coagulation necrosis and intact tissue was observed. Lesion size was controlled by both the variation of generator power and the pulse duration. At a constant pulse duration of 2 seconds, a generator power of 100 W remained below the threshold doses for inducing a reproducible lesion. An increase in power to as high as 400 W induced lesions with average dimensions of as much as 11.2 × 3 mm. At constant total energy (generator power × pulse duration), lesion size increased at higher generator power.Conclusions:This ultrasound generator can induce defined and reproducible necrosis in ex-vivokidney tissue. Lesion size can be controlled by adjusting the generator power and pulse duration. Generator power, in particular, turned out to be a suitable control parameter for obtaining a lesion of a defined size.

Published
2004
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37. Evaluation of Superficial Papillary Ablation by Endoscopic Lasers in an ex VivoKidney Model

Author

Knoll, Thomas, Michel, Maurice Stephan, Cueva-Martínez, Armando, Spahn, Martin, Bross, Stephan, Alken, Peter, and Köhrmann, Kai-Uwe

Abstract

Background and Purpose: Endoscopic examinations of stone-forming kidneys show a coincidence of plaques and microliths on the surface of and within papillary epithelial tissue. These calcifications are thought to be precursors of calcium oxalate urolithiasis. We hypothesized that minimally invasive endoscopic laser ablation of microliths and necrotic cell layers enables epithelial regeneration and prevents recurrent urolithiasis. The aim of this study was to determine the most suitable laser type and dose intensity for selective superficial cell ablation.Materials and Methods: Conventional Nd:YAG (1-40 W) or Ho:YAG (0.5-3 J/single impulse) lasers were used endoscopically on an ex vivoblood-perfused porcine kidney model. Defined doses were applied to the papillary surface in the contact and noncontact modes for 10 to 30 seconds. Papillae were excised after treatment and histopathologically analyzed in continuous sections. Lesions were microscopically assessed with the aid of a Leica Quantimed computer program.Results: Depending on the time and dose, vaporization by the Nd:YAG laser caused large tissue defects and coagulation necrosis at energy levels over 5 W (contact and noncontact mode). Lower energy levels with tissue contact produced only superficial cell defects (<20 cell layers) but more extensive coagulation necrosis, whereas no histologic effects were observed at the same energy level without contact. In contrast, independent of delivered energy but dependent on time, Ho:YAG laser application caused pure tissue loss without relevant coagulation necrosis. The generation of small lesions (6-10 cell layers) without tissue contact was possible at energy levels under 2 J.Conclusions: Selective superficial papillary cell ablation is possible. Low-energy Nd:YAG treatment in the contact mode and Ho:YAG treatment in the noncontact mode led to superficial vaporization with no (Ho:YAG) or minimum (Nd:YAG) coagulation defects.

Published
2002
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38. Corrigendum to: “European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I” [Eur Urol 2008;53:478–96] and to: “European Consensus Conference on Diagnosis and Treatment of Germ Cell Cancer: A Report of the Second Meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part II” [Eur Urol 2008;53:497–513]

Author

Krege, Susanne, Beyer, Jörg, Souchon, Rainer, Albers, Peter, Albrecht, Walter, Algaba, Ferran, Bamberg, Michael, Bodrogi, István, Bokemeyer, Carsten, Cavallin-Ståhl, Eva, Classen, Johannes, Clemm, Christoph, Cohn-Cedermark, Gabriella, Culine, Stéphane, Daugaard, Gedske, De Mulder, Pieter H.M., De Santis, Maria, de Wit, Maike, de Wit, Ronald, Derigs, Hans Günter, Dieckmann, Klaus-Peter, Dieing, Annette, Droz, Jean-Pierre, Fenner, Martin, Fizazi, Karim, Flechon, Aude, Fosså, Sophie D., Garcia del Muro, Xavier, Gauler, Thomas, Geczi, Lajos, Gerl, Arthur, Germa-Lluch, Jose Ramon, Gillessen, Silke, Hartmann, Jörg T., Hartmann, Michael, Heidenreich, Axel, Hoeltl, Wolfgang, Horwich, Alan, Huddart, Robert, Jewett, Michael, Joffe, Johnathan, Jones, William G., Kisbenedek, László, Klepp, Olbjørn, Kliesch, Sabine, Koehrmann, Kai Uwe, Kollmannsberger, Christian, Kuczyk, Markus, Laguna, Pilar, Galvis, Oscar Leiva, Loy, Volker, Mason, Malcolm D., Mead, Graham M., Mueller, Rolf, Nichols, Craig, Nicolai, Nicola, Oliver, Tim, Ondrus, Dalibor, Oosterhof, Gosse O.N., Ares, Luis Paz, Pizzocaro, Giorgio, Pont, Jörg, Pottek, Tobias, Powles, Tom, Rick, Oliver, Rosti, Giovanni, Salvioni, Roberto, Scheiderbauer, Jutta, Schmelz, Hans-Ulrich, Schmidberger, Heinz, Schmoll, Hans-Joachim, Schrader, Mark, Sedlmayer, Felix, Skakkebaek, Niels E., Sohaib, Aslam, Tjulandin, Sergei, Warde, Padraig, Weinknecht, Stefan, Weissbach, Lothar, Wittekind, Christian, Winter, Eva, Wood, Lori, and von der Maase, Hans

Published
2008
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40. Durability of Laser Probes in Interstitial Thermotherapy: Investigations on an ex VivoModel of Effect of Carbonization

Author

Köhrmann, Kai Uwe, Vöhringer, Paul, Michel, Maurice Stephan, Henkel, Thomas, and Alken, Peter

Abstract

Background and Purpose: Interstitial laser application is successful for clinical tissue ablation in various organs. One great drawback of this method is the high costs caused by the vulnerability of the probes. Our objective was to investigate whether the prevention of carbonization deposits on laser probes averts reduced transmission after the application of high laser energy.Materials and Methods: Interstitial laser probes were used to pierce an in vitrokidney model, and 9900 J of energy (Nd:YAG laser) was applied. The transmission of the laser probe was determined and compared with that of a reference probe.Results: The application of laser energy, up to a total of 49,500 J, did not reduce transmission. The deviation of the transmission comparing working probes and the reference probe was between 2% and 7%. The application of high energy (40 W) over a longer period (> 20 seconds) led to carbonization and consequent distinct reduction of transmission.Conclusions: The durability of laser probes can be prolonged by preventing carbonization. The economic effect achieved is the repeated use of the probes at less expense.

Published
2001
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41. Urothelial carcinoma of the ureter, giant rectal stone and sigmoid carcinoma 55 years after ureterosigmoidostomy.

Author

Wilhelm TJ, Knoll T, Weisser G, Grobholz R, Köhrmann KU, and Post S

Subjects
Adenocarcinoma pathology, Humans, Ileum surgery, Male, Middle Aged, Plastic Surgery Procedures, Sigmoidoscopy, Tomography, X-Ray Computed, Ureterostomy, Urinary Bladder surgery, Calculi pathology, Colonic Neoplasms pathology, Rectal Diseases pathology, Ureteral Neoplasms pathology, Urinary Bladder abnormalities, Urinary Bladder Neoplasms pathology
Abstract

We present the case of a unique accumulation of complications 55 years after ureterosigmoidostomy for bladder exstrophy and discuss possible implications for follow-up strategies.

Published
2006
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42. High-intensity focused ultrasound for ex vivo kidney tissue ablation: influence of generator power and pulse duration.

Author

Häcker A, Köhrmann KU, Knoll T, Langbein S, Steidler A, Kraut O, Marlinghaus E, Alken P, and Michel MS

Subjects
Animals, In Vitro Techniques, Kidney pathology, Swine, Ultrasonics, Kidney surgery, Ultrasonic Therapy instrumentation
Abstract

Background and Purpose: The therapeutic application of noninvasive tissue ablation by high-intensity focused ultrasound (HIFU) requires precise physical definition of the focal size and determination of control parameters. The objective of this study was to measure the extent of ex-vivo porcine kidney tissue ablation at variable generator parameters and to identify parameters to control lesion size., Materials and Methods: The ultrasound waves generated by a cylindrical piezoceramic element (1.04 MHz) were focused at a depth of 100 mm using a parabolic reflector (diameter 100 mm). A needle hydrophone was used to measure the field distribution of the sound pressure. The morphology and extent of tissue necrosis were examined at generator powers of up to 400 W (P(el)) and single pulse durations of as long as 8 seconds., Results: The two-dimensional field distribution resulted in an approximately ellipsoidal focus of 32 x 4 mm (-6 dB). A sharp demarcation between coagulation necrosis and intact tissue was observed. Lesion size was controlled by both the variation of generator power and the pulse duration. At a constant pulse duration of 2 seconds, a generator power of 100 W remained below the threshold doses for inducing a reproducible lesion. An increase in power to as high as 400 W induced lesions with average dimensions of as much as 11.2 x 3 mm. At constant total energy (generator power x pulse duration), lesion size increased at higher generator power., Conclusions: This ultrasound generator can induce defined and reproducible necrosis in ex-vivo kidney tissue. Lesion size can be controlled by adjusting the generator power and pulse duration. Generator power, in particular, turned out to be a suitable control parameter for obtaining a lesion of a defined size.

Published
2004
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43. [Frequency and cause of death in patients with testicular germinal tumors at our center: retrospective analysis].

Author

Martínez Portillo FJ, Fernández Arancibia MI, Jünemann KP, Alken P, and Köhrmann KU

Subjects
Adult, Cause of Death, Germinoma therapy, Humans, Male, Patient Compliance, Retrospective Studies, Testicular Neoplasms therapy, Germinoma mortality, Testicular Neoplasms mortality
Abstract

Objective: The introduction of cisplatin in testis cancer therapy significantly reduced the mortality rate. However, data from previous studies indicate that mortality is higher than expected. The aim of our retrospective study in a single center was to evaluate the mortality rate of testicular germ cell tumors. Further to this, a failure analysis was carried out to determine the cause of death, taking the compliance of both the patient and clinician into consideration., Methods: The mortality rate was evaluated in patients referred to and/or treated for testis cancer at the Department of Urology of the Mannheim University Hospital between 1986 and 2000. The causes of death were determined in this group of patients and divided into four categories: 1) death from tumor progression without management failure, 2) death caused by toxicity or side effects of the treatment, 3) death from poor patient compliance, 4) death from poor compliance of the clinician., Results: There were 16 deaths in 139 patients treated up to 2000 (mortality rate 11.5%). The causes were determined as tumor progression and toxicity in 19%. In 31% of the cases, poor compliance of both patient and clinician contributed significantly to the cause of death., Conclusions: Our study supports the theory that negligence to follow the guidelines specified for the treatment of testis cancer may be related to the death of patients with this disease. This could be an explanation for the discrepancy between the expected and actual mortality rate. The quality management of testicular cancer by further standardized failure analysis could reduce the mortality rate.

Published
2002

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