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261 results on '"Köksal, Iftihar"'

2. Prospective cohort study of incidence and risk factors for Catheter-associated Urinary Tract Infections in 212 Intensive Care Units of nine Middle Eastern countries

Author

Jin, Zhilin, Yin, Ruijie, Brown, Eric Christopher, Shukla, Bhavarth, Lee, Brandon Hochahn, Abdulaziz-Alkhawaja, Safaa, Magray, Tahera Anwar, Agha, Hala Mounir, El-Sisi, Amal, El-Kholy, Amani Ali, Bayani, Victor, Daboor, Mohammad Abdellatif, Al-Ruzzieh, Majeda Afeef, Guclu, Ertugrul, Horoz, Ozden Ozgur, Kendirli, Tanil, Koksal, Iftihar, Memish, Ziad A, Olmez-Gazioglu, Esra, Dursun, Oguz, Kara, Tugce Tural, Eroglu, Ahmet, Havan, Merve, Deniz, Suna Secil Ozturk, Aktas, Gizem, Yildizdas, Dincer, Okulu, Emel, Kostekci, Yasemin Ezgi, Omar, Abeer Aly, and Rosenthal, Victor Daniel

Published
2023

3. Immunosuppressive therapy and the risk of hepatitis B reactivation: Consensus report.

Author

Aygen, Bilgehan, Demir, Ahmet Muzaffer, Gümüş, Mahmut, Karabay, Oğuz, Kaymakoğlu, Sabahattin, Köksal, Aydın Şeref, Köksal, İftihar, Örmeci, Necati, and Tabak, Fehmi

Subjects
Humans, Hepatitis B virus, Hepatitis B, Immunosuppressive Agents, Antiviral Agents, Risk Factors, Consensus, Virus Activation, Turkey, Health Services, Hepatitis, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Hepatitis - B, Emerging Infectious Diseases, Liver Disease, Infectious Diseases, Clinical Research, Good Health and Well Being, Gastroenterology & Hepatology
Abstract

This consensus report includes expert opinions and recommendations regarding the screening, and if necessary, the follow-up, prophylaxis, and treatment of hepatitis B before the treatment in patients who will undergo immunosuppressive therapy due to an emergency risk of hepatitis B reactivation. To increase awareness regarding the risk of hepatitis B reactivation in immunosuppressive patients, academicians from several university health research and training centers across Turkey came together and discussed the importance of the subject, current status, and issues in accordance with the current literature data and presented solutions.

Published
2018

4. Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Author

Kayaaslan, Bircan, Hasanoğlu, İmran, Dalkıran, Ayça, Aydos, Ömer, Çınar, Güle, Akdemir-Kalkan, İrem, İnkaya, Ahmet Çağkan, Aydin, Mehtap, Çakir, Hatice, Yıldız, Jale, Kocabıyık, Özenir, Arslan, Sonay, Nallı, Bayram, Demir, Ömer, Singil, Sarp, Ataman-Hatipoğlu, Çiğdem, Tuncer-Ertem, Günay, Kınıklı, Sami, Önal, Uğur, Mete, Bilgül, Dalgan, Gözde, Taşbakan, Meltem, Yamazhan, Tansu, Kömürcüoğlu, Berna, Yalnız, Enver, Benli, Aysun, Keskin-Sarıtaş, Çağla, Ertosun, Mustafa Gökhan, Özkan, Özlenen, Emre, Salih, Arıca, Seçil, Kuşçu, Ferit, Candevir, Aslıhan, Ertürk-Şengel, Buket, Ayvaz, Fadime, Aksoy, Firdevs, Mermutluoğlu, Çiğdem, Demir, Yakup, Günlüoğlu, Gülşah, Tural-Önür, Seda, Kılıç-Toker, Ayşin, Eren, Esma, Otlu, Barış, Mete, Ayşe Özlem, Koçak, Kübra, Ateş, Hale, Koca-Kalkan, İlkay, Aksu, Kurtuluş, Tanriover, Mine Durusu, Doğanay, Hamdi Levent, Akova, Murat, Güner, Hatice Rahmet, Azap, Alpay, Akhan, Sıla, Köse, Şükran, Erdinç, Fatma Şebnem, Akalın, Emin Halis, Tabak, Ömer Fehmi, Pullukçu, Hüsnü, Batum, Özgür, Şimşek Yavuz, Serap, Turhan, Özge, Yıldırmak, Mustafa Taner, Köksal, İftihar, Taşova, Yeşim, Korten, Volkan, Yılmaz, Gürdal, Çelen, Mustafa Kemal, Altın, Sedat, Çelik, İlhami, Bayındır, Yaşar, Karaoğlan, İlkay, Yılmaz, Aydın, Özkul, Aykut, Gür, Hazal, and Unal, Serhat

Published
2021
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18. real life efficacy renal and lipid profile data of tenofovir alafenamide in switched chronic hepatitis patients

Author

İNCE, NEVİN, KÖSE, ŞÜKRAN, GÜNER, HATİCE RAHMET, GÖRENEK, LEVENT, GÜNAL, ÖZGÜR, BATIREL, AYŞE, ÇELEBİ, GÜVEN, TÜRKER, KAMURAN, BOZKURT, İLKNUR, İNAN, DİLARA, çeken, Sebahat, köksal, iftihar, meriç KOÇ, melihe, DÖKMETAŞ, İLYAS, YILDIZ, İLKNUR ESEN, YÖRÜK, GÜLŞEN, KARABAY, OĞUZ, YAMAZHAN, TANSU, BAYKAM, NURCAN, TABAK, ÖMER FEHMİ, YILDIRIM, MUSTAFA, PARLAK, EMİNE, and ŞENER, ALPER

Published
2022

27. Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey

Author

Hızel, Kenan, Türker, Kamuran, Tosun, Selma, Önlen, Yusuf, Bal, Tayibe, Çabalak, Mehmet, Çuvalcı Öztoprak, Nefise, Sarı, Nagehan Didem, Kurtaran, Behice, Şenateş, Ebubekir, Gündüz, Alper, Zerdali, Esra, Karsen, Hasan, Batırel, Ayşe, Karaali, Rıdvan, Güner, Rahmet, Yamazhan, Tansu, Erben, Nurettin, İnce, Nevin, Köksal, İftihar, Sarıgül Yıldırım, Figen, Yörük, Gülşen, Kömür, Süheyla, Kaya, Sibel, Esen, Şaban, Günal, Özgür, Esen Yıldız, İlknur, İnan, Dilara, Barut, Şener, Namıduru, Mustafa, Köse, ŞÜKRAN, Tabak, Fehmi, Sırmatel, Fatma, Kumbasar Karaosmanoğlu, Hayat, Karabay, Oğuz, Sünnetçioğlu, Mahmut, Çelebi, Güven, Akbulut, Ayhan, Gül, Hanefi Cem, User, Ülkü, Can, Güray, Akıncı, Esragül, Duygu, Fazilet, Baykam, Nurcan, Şener, Alper, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Yıldız, İlknur Esen

Subjects
antivirus agent, Male, demography, drug safety, Turkey, Sustained Virologic Response, insomnia, groups by age, Hepacivirus, Turkey (republic), angioneurotic edema, urticaria, Elderly, middle aged, genetics, psychosis, Prospective Studies, adult, clinical trial, cohort analysis, nausea, anemia, medical history, Hepatitis C virus genotype 1, aged, female, Treatment Outcome, drug withdrawal, young adult, Drug Therapy, Combination, headache, prospective study, combination drug therapy, liver cell carcinoma, direct-acting antiviral agents, hyperbilirubinemia, ribavirin, liver cirrhosis, sex difference, elderly, sofosbuvir, Antiviral Agents, Article, Age, turkey (bird), chronic hepatitis C, Humans, human, nonhuman, ledipasvir plus sofosbuvir, constipation, dyspnea, pruritus, Hepatitis C, Chronic, bleeding, major clinical study, drug efficacy, dasabuvir plus ombitasvir plus paritaprevir plus ritonavir, multicenter study, Direct-acting antiviral agents, fatigue, observational study, Chronic Hepatitis C, population research, decompensated liver cirrhosis
Abstract

Background: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C. Methods: In this multicenter prospective study, 2629 eligible chronic hepatitis C patients treated with direct-acting antivirals between April 2017 and December 2019 from 37 Turkish referral centers were divided into 2 age groups: elderly (?65 years) and younger adults (

Published
2022

30. Demographic Characteristics and Transmission Risk Factors of Patients with Hepatitis C Virus in Turkey: The EPI-C, A Multicenter and Cross-sectional Trial

Author

Tabak, Fehmi, primary, Şirin, Göktuğ, additional, Demir, Mehmet, additional, Aladağ, Murat, additional, Sümer, Şua, additional, Kurtaran, Behice, additional, Tosun, Selma, additional, Yamazhan, Tansu, additional, Bozkurt, İlkay, additional, Gürbüz, Yunus, additional, Batırel, Ayşe, additional, Şenateş, Ebubekir, additional, Kandemir, Fatma Özlem, additional, Topal, Firdevs, additional, Doğanay, Hamdi Levent, additional, Sezgin, Orhan, additional, Mıstık, Reşit, additional, Köse, Şükran, additional, Yılmaz, Yusuf, additional, İnan, Dilara, additional, Köksal, İftihar, additional, Parlak, Emine, additional, Akdoğan, Meral, additional, and Güner, Rahmet, additional

Published
2021
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33. In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey.

Author

Yıldırım, Figen Sarıgül, Üser, Ülkü, Sarı, Nagehan Didem, Kurtaran, Behice, Önlen, Yusuf, Şenateş, Ebubekir, Gündüz, Alper, Zerdali, Esra, Karsen, Hasan, Batırel, Ayşe, Karaali, Rıdvan, Güner, Rahmet, Yamazhan, Tansu, Köse, Şükran, Erben, Nurettin, İnce, Nevin, Köksal, İftihar, Öztoprak, Nefise Çuvalcı, Yörük, Gülşen, and Kömür, Süheyla

Published
2022
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35. In-vitro activity of fosfomycin against Escherichia coli and Klebsiella pneumoniae bloodstream isolates and frequency of OXA-48, NDM, KPC, VIM, IMP types of carbapenemases in the carbapenem-resistant groups

Author

Zarakolu, Pınar, primary, Eser, Özgen Köseoğlu, additional, Otlu, Barış, additional, Gürpınar, Öznur, additional, Özakın, Cüneyt, additional, Akalın, Halis, additional, Köksal, İftihar, additional, and Ünal, Serhat, additional

Published
2021
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37. YOĞUN BAKIM ÜNİTELERİNDE KANDAN İZOLE EDİLEN ÖRNEKLERDE KOLİSTİN DUYARLILIĞININ DEĞERLENDİRİLMESİ

Author

KOCABAŞ, Dilek, ÖZBEK, Nurhayat, AYDIN, Nurten Nur, AKSOY, Firdevs, ÖZKAYA, Esra, YILMAZ, Gürdal, and KÖKSAL, İftihar

Subjects
resistance,blood culture,colistin,intensive care unit, Health Care Sciences and Services, polycyclic compounds, biochemical phenomena, metabolism, and nutrition, Sağlık Bilimleri ve Hizmetleri, bacterial infections and mycoses, direnç,kan kültürü,kolistin,yoğun bakım ünitesi
Abstract

Objective: Colistin is frequently used in infections caused by multi-drug resistant Acinetobacter baumannii and Pseudomonas aeruginosa, which cause infections resulting in mortality, especially in intensive care units. In our study, it was aimed to reveal the distribution of colistin resistance rates according to years in A. baumannii and P. aeruginosa strains.Material and Methods: Colistin resistance profile was evaluated in A. baumannii and P. aeruginosa strains isolated from blood and catheter cultures from patients hospitalized in intensive care units at Karadeniz Technical University Health Research and Application Center between January 2013 and October 2019. Demographic, clinical, and laboratory features of the patients; patient files, infection control committee data, and infectious diseases and clinical microbiology consultation forms were obtained.Results: After removing the replications, 555 of the 1469 isolated samples were evaluated. The 555 samples included in this study were isolated from 389 patients, 66.7% of the growths were A. baumannii and 33.3% were P. aeruginosa. Colistin resistance rates in neurosurgery, internal diseases, anesthesiology and reanimation, neurology intensive care units, respectively; 6.3%, 5.2%, 2.6%, 1.9%, while no resistance was detected in the chest intensive care unit. In all intensive care units, the colistin-resistance rate was 3.2%. While the resistance rate increased gradually over the years, it was higher in A. baumannii than in P. aeruginosa. Among patients with colistin-resistant growth, the mortality rate was 77.8% and the overall mortality rate was 3.6%.Conclusion: Colistin resistance rate increase is noted in our study over the years In addition, since resistant breedings are seen to increase mortality, it is thought that to prevent inappropriate and unnecessary use of colistin, to determine the factors that cause resistance, each center should establish treatment protocols by following their epidemiological data and antibiotic susceptibility profile., Amaç: Özellikle yoğun bakım ünitelerinde mortalite ile sonuçlanan enfeksiyonlara neden olan çoklu ilaca dirençli Acinetobacter baumannii ve Pseudomonas aeruginosa’nın sebep olduğu enfeksiyonlarda kolistin sıklıkla kullanılmaktadır. Etkenlerin antimikrobiyal direnç profilleri hastaneden hastaneye hatta hastane içinde farklı üniteler arasında değişiklik gösterebilmektedir. Çalışmamızda izole edilen A. baumannii ve P. aeruginosa suşlarında kolistin direnç oranlarının yıllara göre dağılımını ortaya koymak amaçlanmıştır.Gereç ve Yöntemler: Çalışmada Ocak 2013-Ekim 2019 tarihleri arasında Karadeniz Teknik Üniversitesi Sağlık Araştırma ve Uygulama Merkezi yoğun bakım ünitelerinde yatan hastalardan alınan kan ve kateter kültürlerinden izole edilen A. baumannii ve P. aeruginosa suşlarında kolistin direnç profili değerlendirildi. Hastalara ait demografik, klinik ve laboratuvar özellikleri; hasta dosyaları, enfeksiyon kontrol komite verileri ve enfeksiyon hastalıkları ve klinik mikrobiyoloji konsültasyon formlarından elde edildi.Bulgular: Tekrarlayan üremeler çıkarıldıktan sonra izole edilen 1469 örneğin 555’i değerlendirilmeye alındı. Çalışmaya dâhil edilen 555 örnek, 389 hastadan izole edildi, üremelerin %66.7’si A. baumannii ve %33.3’ü P. aeruginosa idi. Beş yüz elli beş üremenin 18’i kolistin dirençli olup, tüm yoğun bakım ünitelerinde kolistin direnç oranı %3.2 idi. Kolistin direnç oranları nöroşirurji, iç hastalıkları, anesteziyoloji ve reanimasyon ve nöroloji yoğun bakım ünitelerinde sırasıyla; %6.3, %5.2, %2.6, %1.9 iken göğüs yoğun bakım ünitesinde hiç direnç saptanmadı. Yıllara göre her iki suşun da direnç oranının giderek arttığı, A. baumannii’de direnç oranının P. aeruginosa’dan daha yüksek olduğu görüldü. Kolistin dirençli üremesi olan hastalar arasında mortalite oranı %77.8, genel mortalite oranıysa %3.6 olarak hesaplandı.Sonuç: Çalışmamızda yıllar içinde kolistin direnç oranlarındaki artış dikkati çekmektedir. Ayrıca dirençli olan üremelerin mortaliteyi de artırdığı görüldüğünden; uygunsuz ve gereksiz kolistin kullanımının engellenmesi, dirence yol açan faktörlerin belirlenmesi, her merkezin kendi epidemiyolojik verilerini ve antimikrobiyal duyarlılık profilini takip ederek tedavi protokolleri oluşturması gerektiği düşünülmektedir.

Published
2021

38. Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Author

Tanriover, Mine Durusu, primary, Doğanay, Hamdi Levent, additional, Akova, Murat, additional, Güner, Hatice Rahmet, additional, Azap, Alpay, additional, Akhan, Sıla, additional, Köse, Şükran, additional, Erdinç, Fatma Şebnem, additional, Akalın, Emin Halis, additional, Tabak, Ömer Fehmi, additional, Pullukçu, Hüsnü, additional, Batum, Özgür, additional, Şimşek Yavuz, Serap, additional, Turhan, Özge, additional, Yıldırmak, Mustafa Taner, additional, Köksal, İftihar, additional, Taşova, Yeşim, additional, Korten, Volkan, additional, Yılmaz, Gürdal, additional, Çelen, Mustafa Kemal, additional, Altın, Sedat, additional, Çelik, İlhami, additional, Bayındır, Yaşar, additional, Karaoğlan, İlkay, additional, Yılmaz, Aydın, additional, Özkul, Aykut, additional, Gür, Hazal, additional, Unal, Serhat, additional, Kayaaslan, Bircan, additional, Hasanoğlu, İmran, additional, Dalkıran, Ayça, additional, Aydos, Ömer, additional, Çınar, Güle, additional, Akdemir-Kalkan, İrem, additional, İnkaya, Ahmet Çağkan, additional, Aydin, Mehtap, additional, Çakir, Hatice, additional, Yıldız, Jale, additional, Kocabıyık, Özenir, additional, Arslan, Sonay, additional, Nallı, Bayram, additional, Demir, Ömer, additional, Singil, Sarp, additional, Ataman-Hatipoğlu, Çiğdem, additional, Tuncer-Ertem, Günay, additional, Kınıklı, Sami, additional, Önal, Uğur, additional, Mete, Bilgül, additional, Dalgan, Gözde, additional, Taşbakan, Meltem, additional, Yamazhan, Tansu, additional, Kömürcüoğlu, Berna, additional, Yalnız, Enver, additional, Benli, Aysun, additional, Keskin-Sarıtaş, Çağla, additional, Ertosun, Mustafa Gökhan, additional, Özkan, Özlenen, additional, Emre, Salih, additional, Arıca, Seçil, additional, Kuşçu, Ferit, additional, Candevir, Aslıhan, additional, Ertürk-Şengel, Buket, additional, Ayvaz, Fadime, additional, Aksoy, Firdevs, additional, Mermutluoğlu, Çiğdem, additional, Demir, Yakup, additional, Günlüoğlu, Gülşah, additional, Tural-Önür, Seda, additional, Kılıç-Toker, Ayşin, additional, Eren, Esma, additional, Otlu, Barış, additional, Mete, Ayşe Özlem, additional, Koçak, Kübra, additional, Ateş, Hale, additional, Koca-Kalkan, İlkay, additional, and Aksu, Kurtuluş, additional

Published
2021
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39. Trabzon’da 20 Yaş ve Üzeri Bireylerde Toksoplazmoz Seroprevalansı

Author

Karakullukçu, Serdar, primary, Beyhun, Nazım Ercüment, additional, Kaklıkkaya, Neşe, additional, Köksal, İftihar, additional, Topbaş, Murat, additional, Buruk, Celal Kurtuluş, additional, Çan, Gamze, additional, Yılmaz, Mustafa, additional, Hamzaoğlu, Köksal, additional, Sayın, Esin, additional, and Kolaylı, Cevriye Ceyda, additional

Published
2021
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44. Comparative activity of carbapenem testing: the COMPACT study

Author

Nordmann, Patrice, Picazo, Juan J., Mutters, Reinier, Korten, Volkan, Quintana, Alvaro, Laeuffer, Joerg M., Seak, Joyce Chen Hian, Flamm, Robert K., Morrissey, Ian, Azadian, Berge, El-Bouri, Khalid, Jones, Graeme, Masterton, Bob, Morgan, Marina, Oppenheim, Beryl, Waghorn, David, Smyth, Edmond, Abele-Horn, Marianne, Jacobs, Enno, Mai, Uwe, Mutters, Reinier, Pfister, Wolfgang, Schoerner, Christoph, Seifert, Harald, Bebear, Cécile, Bingen, Edouard, Bonnet, Richard, Jehl, François, Levy, Pierre-Yves, Nordmann, Patrice, Delvallez, Micheline Roussel, Paniara, Olga, Papaparaskevas, Joseph, Piotr, Heczko, Kolář, Milan, Žemličková, Helena, Hanzen, Juraj, Kotulová, Daniela, Campa, Mario, Fadda, Giovanni, Fortina, Giacomo, Gesu, Giovanni, Manso, Esther, Milano, Fulvia, Nicoletti, Giuseppe, Pucillo, Leopoldo, Rigoli, Roberto, Rossolini, Gianmaria, Sambri, Vittorio, Sarti, Mario, Akaln, Halis, Snrtaş, Melda, Akova, Murat, Hasçelik, Gülşen, Arman, Dilek, Dizbay, Murat, Aygen, Bilgehan, Sümerkan, Bülent, Dokuzoğuz, Başak, Esener, Harika, Eraksoy, Haluk, Başaran, Seniha, Köksal, İftihar, Bayramoğlu, Gülçin, Korten, Volkan, Söyletir, Güner, Ulusoy, Sercan, Tünger, Alper, Yalçn, Ata Nevzat, Öğünç, Dilara, Bou, Germán, Bouza, Emilio, Canton, Rafael, Coll, Pere, García-Rodriguez, José Ángel, Gimeno, Concepción, Gobernado, Miguel, Bertomeu, Frederic Gomez, Gómez-Garcés, José Luis, Marco, Francesc, Martínez-Martínez, Luis, Pascual, Alvaro, Pérez, José Luis, Picazo, Juan, Prats, Guillem, Linares, Maria Saumoy, Ghaly, Farid, Cristino, Melo, Diogo, Jose, Ramos, Helena, Balode, Arta, Jürna-Ellam, Marika, and Koslov, Roman

Published
2011
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49. Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study

Author

Bus, Liesbet De, Depuydt, Pieter, Steen, Johan, Dhaese, Sofie, Smet, Ken De, Tabah, Alexis, Akova, Murat, Cotta, Menino Osbert, Pascale, Gennaro De, Dimopoulos, George, Fujitani, Shigeki, Garnacho-Montero, Jose, Leone, Marc, Lipman, Jeffrey, Ostermann, Marlies, Paiva, José-Artur, Schouten, Jeroen, Sjövall, Fredrik, Timsit, Jean-François, Roberts, Jason A., Zahar, Jean-Ralph, Zand, Farid, Zirpe, Kapil, Waele, Jan J. De, Rios, Fernando, Vazquez, Alejandro Risso, Vidal, Maria Gabriela, Zakalik, Graciela, Attokaran, Antony George, Banakh, Iouri, Dey-Chatterjee, Smita, Ewan, Julie, Ferrier, Janet, Forbes, Loretta, Fourie, Cheryl, Leditschke, Anne, Murray, Lauren, Eller, Philipp, Biston, Patrick, Bracke, Stephanie, Crop, Luc De, Schryver, Nicolas De, Frans, Eric, Spapen, Herbert, Malderen, Claire Van, Vansteelandt, Stijn, Vermeiren, Daisy, Arévalo, Elias Pablo, Crespo, Mónica, Flores, Roberto Zelaya, Píza, Petr, Tutillo, Diego Morocho, Elme, Andreas, Kallaste, Anne, Starkopf, Joel, Bourenne, Jeremy, Calypso, Mathieu, Cohen, Yves, Dahyot-Fizelier, Claire, Depret, François, Guillot, Max, Imzi, Nadia, Jochmans, Sebastien, Kouatchet, Achille, Lepape, Alain, Martin, Olivier, Heim, Markus, Schaller, Stefan J, Arvaniti, Kostoula, Bekridelis, Anestis, Ioannidis, Panagiotis, Mitrakos, Cornelia, Papanikolaou, Metaxia N., Pouriki, Sofia, Vemvetsou, Anna, Abraham, Babu, Bhattacharya, Pradip Kumar, Budugu, Anusha, Dixit, Subhal, Gurav, Sushma, Kandanuri, Padmaja, Prabhu, Dattatray Arun, Rathod, Darshana, Savaru, Kavitha, Udupa, Ashwin Neelavar, Varghese, Sunitha Binu, Bakhodaei, Hossein Haddad, Dabiri, Gholamreza, Fallahi, Mohammad Javad, Feiz, Farnia, Firoozifar, Mohammad, Khaloo, Vahid, Maghsudi, Behzad, Masjedi, Mansoor, Nikandish, Reza, Sabetian, Golnar, Marsh, Brian, Martin-Loeches, Ignacio, Steiner, Jan, Barbagallo, Maria, Caricato, Anselmo, Cortegiani, Andrea, D’Andrea, Rocco, Deana, Cristian, Donati, Abele, Girardis, Massimo, Mandalà, Giuliana, Panarello, Giovanna, Pasero, Daniela, Pelagalli, Lorella, Soave, Paolo Maurizio, Spadaro, Savino, Fujita, Yoshihito, Fujiwara, Shinsuke, Hara, Yuya, Hashi, Hideki, Hashimoto, Satoru, Hashimoto, Hideki, Hayakawa, Katsura, Inoue, Masash, Isokawa, Shutaro, Kameda, Shinya, Kamohara, Hidenobu, Kanamoto, Masafumi, Katayama, Shinshu, Kawagishi, Toshiomi, Kawano, Yasumasa, Kida, Yoshiko, Kita, Mami, Kobayashi, Atsuko, Kuriyama, Akira, Naito, Takaki, Nashiki, Hiroshi, Nishiyama, Kei, Shindo, Shunsuke, Suzuki, Taketo, Takaba, Akihiro, Tanaka, Chie, Tetsuya, Komuro, Tomioka, Yoshihiro, Yanagawa, Youichi, Yoshida, Hideki, Adnan, Syamhanin, Hasan, Mohd Shahnaz, Sulaiman, Helmi, Lopez, Gilberto A. Gasca, Hernández-Cárdenas, Carmen M., Ñamendys-Silva, Silvio A., Bethlehem, Carina, Lange, Dylan de, Hunfeld, Nicole, Numan, Sandra, Leeuwen, Henk van, Owens, Daniel, Almeida, Mónica, Fragoso, Elsa, Leonor, Tiago, Pereira, José-Manuel, Filipescu, Daniela, Grigoras, Ioana, Popescu, Mihai, Tomescu, Dana, Alshahrani, Mohammed S., Alvarez-Gonzalez, Manuel, Barrero-García, Irene, Blasco-Navalpotro, Miguel Angel, Claverias, Laura, Estella, Ángel, Espina, Lorena Forcelledo, Garmendia, Jose Luis Garcia, Prieto, Emilio García, Gómez-Prieto, Gracia, Conde, Carlos Jiménez, Sagasti, Fernando Martinez, Cantero, Alicia Muñoz, Orejas-Gallego, Alberto, Papiol, Elisabeth, Pérez-Civantos, Demetrio, Laderas, Juan Carlos Pozo, Álvarez, Josep Trenado, Vera-Artázcoz, Paula, Cortés, Pablo Vidal, Oldner, Anders, Spångfors, Martin, Alp, Emine, Köksal, Iftihar, Korten, Volkan, Özveren, Arife, Hall, Anna, Hatton, Kevin W., Laudanski, Krzysztof, other, and, Bus, Liesbet De, Depuydt, Pieter, Steen, Johan, Dhaese, Sofie, Smet, Ken De, Tabah, Alexis, Akova, Murat, Cotta, Menino Osbert, Pascale, Gennaro De, Dimopoulos, George, Fujitani, Shigeki, Garnacho-Montero, Jose, Leone, Marc, Lipman, Jeffrey, Ostermann, Marlies, Paiva, José-Artur, Schouten, Jeroen, Sjövall, Fredrik, Timsit, Jean-François, Roberts, Jason A., Zahar, Jean-Ralph, Zand, Farid, Zirpe, Kapil, Waele, Jan J. De, Rios, Fernando, Vazquez, Alejandro Risso, Vidal, Maria Gabriela, Zakalik, Graciela, Attokaran, Antony George, Banakh, Iouri, Dey-Chatterjee, Smita, Ewan, Julie, Ferrier, Janet, Forbes, Loretta, Fourie, Cheryl, Leditschke, Anne, Murray, Lauren, Eller, Philipp, Biston, Patrick, Bracke, Stephanie, Crop, Luc De, Schryver, Nicolas De, Frans, Eric, Spapen, Herbert, Malderen, Claire Van, Vansteelandt, Stijn, Vermeiren, Daisy, Arévalo, Elias Pablo, Crespo, Mónica, Flores, Roberto Zelaya, Píza, Petr, Tutillo, Diego Morocho, Elme, Andreas, Kallaste, Anne, Starkopf, Joel, Bourenne, Jeremy, Calypso, Mathieu, Cohen, Yves, Dahyot-Fizelier, Claire, Depret, François, Guillot, Max, Imzi, Nadia, Jochmans, Sebastien, Kouatchet, Achille, Lepape, Alain, Martin, Olivier, Heim, Markus, Schaller, Stefan J, Arvaniti, Kostoula, Bekridelis, Anestis, Ioannidis, Panagiotis, Mitrakos, Cornelia, Papanikolaou, Metaxia N., Pouriki, Sofia, Vemvetsou, Anna, Abraham, Babu, Bhattacharya, Pradip Kumar, Budugu, Anusha, Dixit, Subhal, Gurav, Sushma, Kandanuri, Padmaja, Prabhu, Dattatray Arun, Rathod, Darshana, Savaru, Kavitha, Udupa, Ashwin Neelavar, Varghese, Sunitha Binu, Bakhodaei, Hossein Haddad, Dabiri, Gholamreza, Fallahi, Mohammad Javad, Feiz, Farnia, Firoozifar, Mohammad, Khaloo, Vahid, Maghsudi, Behzad, Masjedi, Mansoor, Nikandish, Reza, Sabetian, Golnar, Marsh, Brian, Martin-Loeches, Ignacio, Steiner, Jan, Barbagallo, Maria, Caricato, Anselmo, Cortegiani, Andrea, D’Andrea, Rocco, Deana, Cristian, Donati, Abele, Girardis, Massimo, Mandalà, Giuliana, Panarello, Giovanna, Pasero, Daniela, Pelagalli, Lorella, Soave, Paolo Maurizio, Spadaro, Savino, Fujita, Yoshihito, Fujiwara, Shinsuke, Hara, Yuya, Hashi, Hideki, Hashimoto, Satoru, Hashimoto, Hideki, Hayakawa, Katsura, Inoue, Masash, Isokawa, Shutaro, Kameda, Shinya, Kamohara, Hidenobu, Kanamoto, Masafumi, Katayama, Shinshu, Kawagishi, Toshiomi, Kawano, Yasumasa, Kida, Yoshiko, Kita, Mami, Kobayashi, Atsuko, Kuriyama, Akira, Naito, Takaki, Nashiki, Hiroshi, Nishiyama, Kei, Shindo, Shunsuke, Suzuki, Taketo, Takaba, Akihiro, Tanaka, Chie, Tetsuya, Komuro, Tomioka, Yoshihiro, Yanagawa, Youichi, Yoshida, Hideki, Adnan, Syamhanin, Hasan, Mohd Shahnaz, Sulaiman, Helmi, Lopez, Gilberto A. Gasca, Hernández-Cárdenas, Carmen M., Ñamendys-Silva, Silvio A., Bethlehem, Carina, Lange, Dylan de, Hunfeld, Nicole, Numan, Sandra, Leeuwen, Henk van, Owens, Daniel, Almeida, Mónica, Fragoso, Elsa, Leonor, Tiago, Pereira, José-Manuel, Filipescu, Daniela, Grigoras, Ioana, Popescu, Mihai, Tomescu, Dana, Alshahrani, Mohammed S., Alvarez-Gonzalez, Manuel, Barrero-García, Irene, Blasco-Navalpotro, Miguel Angel, Claverias, Laura, Estella, Ángel, Espina, Lorena Forcelledo, Garmendia, Jose Luis Garcia, Prieto, Emilio García, Gómez-Prieto, Gracia, Conde, Carlos Jiménez, Sagasti, Fernando Martinez, Cantero, Alicia Muñoz, Orejas-Gallego, Alberto, Papiol, Elisabeth, Pérez-Civantos, Demetrio, Laderas, Juan Carlos Pozo, Álvarez, Josep Trenado, Vera-Artázcoz, Paula, Cortés, Pablo Vidal, Oldner, Anders, Spångfors, Martin, Alp, Emine, Köksal, Iftihar, Korten, Volkan, Özveren, Arife, Hall, Anna, Hatton, Kevin W., Laudanski, Krzysztof, and other, and

Abstract

Purpose: The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation. Methods: Adult ICU patients receiving empirical antimicrobial therapy for bacterial infection were studied in a prospective observational study from October 2016 until May 2018. ADE was defined as (1) discontinuation of an antimicrobial in case of empirical combination therapy or (2) replacement of an antimicrobial with the intention to narrow the antimicrobial spectrum, within the first 3 days of therapy. Inverse probability (IP) weighting was used to account for time-varying confounding when estimating the effect of ADE on clinical cure. Results: Overall, 1495 patients from 152 ICUs in 28 countries were studied. Combination therapy was prescribed in 50%, and carbapenems were prescribed in 26% of patients. Empirical therapy underwent ADE, no change and change other than ADE within the first 3 days in 16%, 63% and 22%, respectively. Unadjusted mortality at day 28 was 15.8% in the ADE cohort and 19.4% in patients with no change [p = 0.27; RR 0.83 (95% CI 0.60–1.14)]. The IP-weighted relative risk estimate for clinical cure comparing ADE with no-ADE patients (no change or change other than ADE) was 1.37 (95% CI 1.14–1.64). Conclusion: ADE was infrequently applied in critically ill-infected patients. The observational effect estimate on clinical cure suggested no deleterious impact of ADE compared to no-ADE. However, residual confounding is likely.

Published
2020

50. Erişkin aşılaması, uygulamadaki sorunlar ve çözüm önerileri, aile hekimlerinin erişkin aşılamasındaki rolü

Author

Toprak, Dilek, Köksal, İftihar, Sargın, Mehmet, Akan, Hülya, Toprak, Dilek, Köksal, İftihar, Sargın, Mehmet, Akan, Hülya, and Yeditepe Üniversitesi

Abstract

Enfeksiyon hastalıklarından korunmada en etkili ve ucuz yöntem aşılamadır. Türkiye’de çocukluk çağı için oldukça başarıyla uygulanan Genişletilmiş Bağışıklama Programı olmasına rağmen erişkin bağışıklamasında hedeflenen oranlara ulaşılamamıştır. Erişkin bağışıklama oranları riskli gruplar için bile istenen düzeylerde değildir. Erişkin aşılamasında istenen hedefe ulaşmak için öncelikle aşı programdaki eksiklerin bilinmesi ve farkın-dalık yaratılması esastır. Bu amaçla ulusal düzeyde iyileştirme çalışmalarına ihtiyaç bulunmaktadır. Koruyucu hekimliğin ayrılmaz parçası olarak bağışıklamada, aile hekimlerine önemli görevler düşmektedir. Bu derleme erişkin aşılamaları hakkında farkındalık yaratmak, mevcut durumu gözden geçirmek ve aşılama oranlarının artırılabilmesi için yapılması gerekenleri aile hekimliği bakış açısı ile vurgulamak amacıyla yazılmıştır. The most effective and economical method of preventing infectious diseases is vaccination. In Turkey, although there is a vaccination scheme for childhood period within the scope of the Expanded Program on Immunization, which is performing succesfully, the aimed ratios for adult immunisation have not been achieved. Adult immunization rates are not at desirable levels even for risky groups. In order to achieve a desired goal in adult vaccination, it is essential to know deficiencies of the program and to create awareness. For this purpose, improvement efforts at the national level are needed. Family physicians have important roles in adult immunizationa as being an essential part of preventive medicine. This review was written to raise awareness about adult immunization, to monitor the current situation, and to establish a framework for what needs to be done in the view of family medicine.

Published
2018

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