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445 results on '"Kühl, Uwe"'

3. Bromocriptine treatment in patients with peripartum cardiomyopathy and right ventricular dysfunction

Author

Haghikia, Arash, Schwab, Johannes, Vogel-Claussen, Jens, Berliner, Dominik, Pfeffer, Tobias, König, Tobias, Zwadlo, Carolin, Moulig, Valeska Abou, Franke, Annegret, Schwarzkopf, Marziel, Ehlermann, Philipp, Pfister, Roman, Michels, Guido, Westenfeld, Ralf, Stangl, Verena, Kühl, Uwe, Podewski, Edith, Kindermann, Ingrid, Böhm, Michael, Sliwa, Karen, Hilfiker-Kleiner, Denise, and Bauersachs, Johann

Published
2019
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13. Adressen

Author

Ludwig, Malte, primary, Benckert, Julia, additional, Berg, Thomas, additional, Bornstein, Stefan, additional, Breitkreutz, Christian, additional, Engelmann, Cornelius, additional, Frank, Helga, additional, Fritzsche, Carlos, additional, Graf, Nicolas, additional, Grohé, Christian, additional, Gruber, Matthias, additional, Hering, Thomas, additional, Humboldt, Tim, additional, Junge, Tanja, additional, Kluge, Stefan, additional, Kochanek, Matthias, additional, Koerfer, Peter, additional, Kühl, Uwe, additional, Labenz, Joachim, additional, Lawall, Holger, additional, Lepper, Wolfgang, additional, Löbermann, Micha, additional, Möhlenkamp, Stefan, additional, Möller, Lars, additional, Müller, Karin A.L., additional, Neumann, Till, additional, Patschan, Susann A., additional, Pletz, Mathias W., additional, Reising, Kurt D., additional, Reisinger, Emil C., additional, Rünzi, Michael, additional, Sander, Dirk, additional, Schindler, Ralf, additional, Schleenvoigt, Benjamin T., additional, Schmidmaier, Ralf, additional, Schmitz, Udo, additional, Schobel, Hans-Paul, additional, Scholze, Jürgen E., additional, Schwartz, Stefan, additional, Sefrin, Peter, additional, Serke, Monika, additional, Sieber, Dirk K.C., additional, Spannagl, Michael, additional, Specker, Christof, additional, Stiegler, Hubert, additional, Straka, Christian, additional, Tschöpe, Carsten, additional, Volkmann, Hans-Jürgen, additional, Weber, Michael, additional, Klütsch, Klaus, additional, Tischer, Katja, additional, von Weizsäcker, Fritz, additional, Worth, Heinrich, additional, and Zöpf, Thomas, additional

Published
2017
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18. Infektionen des Herzens

Author

Schultheiß, Heinz-Peter, Kühl, Uwe, Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor

Published
2005
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19. Kardiomyopathien

Author

Strauer, Bodo-Eckhard, Schultheiß, Heinz-Peter, Kühl, Uwe, Brehm, Michael, Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor

Published
2005
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20. Erkrankungen von Herz und Gefäßen

Author

Drexler, Helmut, Kuck, Karl-Heinz, Ernst, Sabine, Hermann, Hans-Peter, Hasenfuss, Gerd, Horstkotte, Dieter, Piper, Cornelia, Wagener, Juliane, Strauer, Bodo-Eckhard, Schultheiss, Heinz-Peter, Kühl, Uwe, Brehm, Michael, Hausmann, Dirk, Neumann, Franz-Josef, Schömig, Albert, Hamm, Christian, Fliser, Danilo, Menne, Jan, Radermacher, Jörg, Haller, Hermann, Nienaber, Christoph A., Diehm, Curt, Hausdorf, Gerd, Strauer, Bodo Eckhard, Schwalen, Andreas, Schölmerich, Jürgen, editor, Burdach, Stefan, editor, Diehl, Volker, editor, Drexler, Helmut, editor, Hiddemann, Wolfgang, editor, Hörl, Walter H., editor, Klein, Helmfried, editor, Landthaler, Michael, editor, Lenz, Kurt, editor, Mann, Klaus, editor, Mössner, Joachim, editor, Müller-Ladner, Ulf, editor, Reichen, Jürg, editor, Schmiegel, Wolff, editor, Schröder, Johann Oltmann, editor, Seeger, Werner, editor, Stremmel, Wolfgang, editor, Suttorp, Norbert, editor, and Weilemann, L. Sacha, editor

Published
2003
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24. Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis

Author

Pappritz, Kathleen, primary, Lin, Jie, additional, El‐Shafeey, Muhammad, additional, Fechner, Henry, additional, Kühl, Uwe, additional, Alogna, Alessio, additional, Spillmann, Frank, additional, Elsanhoury, Ahmed, additional, Schulz, Rainer, additional, Tschöpe, Carsten, additional, and Van Linthout, Sophie, additional

Published
2022
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27. Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis

Author

Müller, Irene, Vogl, Thomas, Kühl, Uwe, Krannich, Alexander, Banks, Aron, Trippel, Tobias, Noutsias, Michel, Maisel, Alan S., van Linthout, Sophie, and Tschöpe, Carsten

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, Stroke Volume, Ventricular Function, Left, Myocarditis, S100A8/S100A9, lcsh:RC666-701, Original Research Articles, Alarmins, Humans, Endomyocardial biopsy, Original Research Article, Biomarkers, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Aims: The alarmin S100A8/S100A9 (S100A8/A9) is released by activated monocytes/macrophages and neutrophils in the setting lymphocytic myocarditis (MC). We recently demonstrated its therapeutic potential in experimental acute MC. Now, we investigated the diagnostic relevance of S100A8/A9 serum levels in patients with suspected acute and chronic MC and in patients with heart failure without cardiac inflammation. Methods and Results: Serum S100A8/A9 levels were analysed in patients with a recent onset of MC [��� 30 days, n = 32; ejection fraction (EF): 45.4 �� 12.9%], dilated cardiomyopathy patients with inflammation (n = 112; EF: 29.0 �� 11.4%), or without inflammation (n = 58; EF: 26.6 �� 9.3%), and controls (n = 25; EF: 68.5 �� 4.6%), by using specific ELISAs. Blood samples were collected at Time Point 1 (T1), where also endomyocardial biopsies (EMBs) were withdrawn. Patients with a recent onset of MC showed a 4.6-fold increase in serum S100A8/A9 levels vs. controls (MC: 1948 �� 1670 ng/mL vs. controls: 426 �� 307 ng/mL; P < 0.0001). Serum S100A8/A9 correlated with the disease activity, represented by EMB-derived counts of inflammatory cells (CD3: r = 0.486, P = 0.0047, lymphocyte function-associated antigen-1: r = 0.558, P = 0.0009, macrophage-1 antigen: r = 0.434, P = 0.013), the EMB mRNA levels of S100A8, S100A9 (r = 0.541, P = 0.002), and left ventricular ejection fraction (LVEF: r = 0.498, P = 0.0043). EMB immunofluorescence co-stainings display macrophages/monocytes and neutrophils as the main source of S100A8 and S100A9 in recent onset MC. The diagnostic value of serum alarmin levels (cut-off 583 ng/mL) was characterized by a specificity of 92%, a sensitivity of 90.6%, positive predictive value of 93.5%, negative predictive value of 88.5%, and an accuracy of 0.949 (95% confidence interval [0.89-1]). In a subgroup of MC patients, S100A8/A9 serum levels and EMBs at T1 (n = 12) and a follow-up visit (T2, n = 12, mean follow-up 8.5 months) were available. A fall of serum S100A8/A9 (T1: 2208 �� 1843 ng/mL vs. T2: 888.8 �� 513.7 ng/mL; P = 0.00052) was associated with a reduced cardiac inflammation (CD3 T1: 70.02 �� 107.4 cells per square millimetre vs. T2: 59.18 �� 182.5 cells per square millimetre; P = 0.0342, lymphocyte function-associated antigen-1 T1: 133.5 �� 187.1 cells per square millimetre vs. T2: 74.12 �� 190.5 cells per square millimetre; P = 0.0186, and macrophage-1 antigen T1: 132.6 �� 129.5 cells per square millimetre vs. T2: 54.41 �� 65.16 cells per square millimetre; P = 0.0015). Serum S100A8/A9 levels were only slightly increased in patients within the chronic phase of MC and in heart failure patients without inflammation vs. controls. Conclusions: Serum S100A8/A9 might serve as an additional tool in the diagnostic workup of suspected acute MC patients.

Published
2020

28. Entzündliche Herzmuskelerkrankung

Author

Schultheiss, Heinz-Peter, Pauschinger, Matthias, Dörner, Andrea, Kühl, Uwe, Bilger, Johannes, Schwimmbeck, Peter Lothar, Ganten, Detlev, editor, and Ruckpaul, Klaus, editor

Published
1998
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37. Wearable cardioverter‐defibrillator: friend or foe in suspected myocarditis?

Author

Blaschke, Florian, primary, Lacour, Philipp, additional, Dang, Phi Long, additional, Parwani, Abdul Shokor, additional, Hohendanner, Felix, additional, Walter, Thula, additional, Klingel, Karin, additional, Kühl, Uwe, additional, Heinzel, Frank R., additional, Sherif, Mohammad, additional, Boldt, Leif‐Hendrik, additional, Pieske, Burkert, additional, and Tschöpe, Carsten, additional

Published
2021
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40. A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy

Author

Meder, Benjamin, Rühle, Frank, Weis, Tanja, Homuth, Georg, Keller, Andreas, Franke, Jennifer, Peil, Barbara, Lorenzo Bermejo, Justo, Frese, Karen, Huge, Andreas, Witten, Anika, Vogel, Britta, Haas, Jan, Völker, Uwe, Ernst, Florian, Teumer, Alexander, Ehlermann, Philipp, Zugck, Christian, Friedrichs, Frauke, Kroemer, Heyo, Dörr, Marcus, Hoffmann, Wolfgang, Maisch, Bernhard, Pankuweit, Sabine, Ruppert, Volker, Scheffold, Thomas, Kühl, Uwe, Schultheiss, Hans-Peter, Kreutz, Reinhold, Ertl, Georg, Angermann, Christiane, Charron, Philippe, Villard, Eric, Gary, Françoise, Isnard, Richard, Komajda, Michel, Lutz, Matthias, Meitinger, Thomas, Sinner, Moritz F., Wichmann, H.-Erich, Krawczak, Michael, Ivandic, Boris, Weichenhan, Dieter, Gelbrich, Goetz, El-Mokhtari, Nour-Eddine, Schreiber, Stefan, Felix, Stephan B., Hasenfu, Gerd, Pfeufer, Arne, Hübner, Norbert, Kääb, Stefan, Arbustini, Eloisa, Rottbauer, Wolfgang, Frey, Norbert, Stoll, Monika, and Katus, Hugo A.

Published
2014
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