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1. Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society

Author

Kühn, Tilman, Kalotai, Nicole, Amini, Anna M., Haardt, Julia, Lehmann, Andreas, Schmidt, Annemarie, Buyken, Anette E., Egert, Sarah, Ellinger, Sabine, Kroke, Anja, Lorkowski, Stefan, Louis, Sandrine, Schulze, Matthias B., Schwingshackl, Lukas, Siener, Roswitha, Stangl, Gabriele I., Watzl, Bernhard, Zittermann, Armin, and Nimptsch, Katharina

Published
2024
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4. Correction to: Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort

Author

Stepien, Magdalena, Duarte-Salles, Talita, Fedirko, Veronika, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Klinaki, Eleni, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Naccarati, Alessio, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Parr, Christine L., Quirós, José Ramón, Buckland, Genevieve, Molina-Montes, Esther, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Wennberg, Maria, Nilsson, Lena Maria, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Ward, Heather A., Romieu, Isabelle, and Jenab, Mazda

Published
2024
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5. Protein intake and body weight, fat mass and waist circumference: an umbrella review of systematic reviews for the evidence-based guideline on protein intake of the German Nutrition Society

Author

Ellinger, Sabine, Amini, Anna M., Haardt, Julia, Lehmann, Andreas, Schmidt, Annemarie, Bischoff-Ferrari, Heike A., Buyken, Anette E., Kroke, Anja, Kühn, Tilman, Louis, Sandrine, Lorkowski, Stefan, Nimptsch, Katharina, Schulze, Matthias B., Schwingshackl, Lukas, Siener, Roswitha, Stangl, Gabriele I., Volkert, Dorothee, Zittermann, Armin, Watzl, Bernhard, and Egert, Sarah

Published
2024
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6. Protein intake and type 2 diabetes mellitus: an umbrella review of systematic reviews for the evidence-based guideline for protein intake of the German Nutrition Society

Author

Schulze, Matthias B., Haardt, Julia, Amini, Anna M., Kalotai, Nicole, Lehmann, Andreas, Schmidt, Annemarie, Buyken, Anette E., Egert, Sarah, Ellinger, Sabine, Kroke, Anja, Kühn, Tilman, Louis, Sandrine, Nimptsch, Katharina, Schwingshackl, Lukas, Siener, Roswitha, Zittermann, Armin, Watzl, Bernhard, and Lorkowski, Stefan

Published
2024
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10. Association between substituting macronutrients and all-cause mortality: a network meta-analysis of prospective observational studies

Author

Wallerer, Sabina, Papakonstantinou, Theodoros, Morze, Jakub, Stadelmaier, Julia, Kiesswetter, Eva, Gorenflo, Lea, Barbaresko, Janett, Szczerba, Edyta, Neuenschwander, Manuela, Bell, William, Kühn, Tilman, Lohner, Szimonetta, Guasch-Ferré, Marta, Hoffmann, Georg, Meerpohl, Joerg J., Schlesinger, Sabrina, Nikolakopoulou, Adriani, and Schwingshackl, Lukas

Published
2024
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11. Protein intake and risk of urolithiasis and kidney diseases: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society

Author

Remer, Thomas, Kalotai, Nicole, Amini, Anna M., Lehmann, Andreas, Schmidt, Annemarie, Bischoff-Ferrari, Heike A., Egert, Sarah, Ellinger, Sabine, Kroke, Anja, Kühn, Tilman, Lorkowski, Stefan, Nimptsch, Katharina, Schwingshackl, Lukas, Zittermann, Armin, Watzl, Bernhard, and Siener, Roswitha

Published
2023
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15. Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study

Author

Tsilidis, Konstantinos K, Papadimitriou, Nikos, Dimou, Niki, Gill, Dipender, Lewis, Sarah J, Martin, Richard M, Murphy, Neil, Markozannes, Georgios, Zuber, Verena, Cross, Amanda J, Burrows, Kimberley, Lopez, David S, Key, Timothy J, Travis, Ruth C, Perez-Cornago, Aurora, Hunter, David J, van Duijnhoven, Fränzel JB, Albanes, Demetrius, Arndt, Volker, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Boehm, Juergen, Brenner, Hermann, Burnett-Hartman, Andrea, Campbell, Peter T, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, de la Chapelle, Albert, Figueiredo, Jane C, Gallinger, Steven J, Giles, Graham G, Goodman, Phyllis J, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Hoffmeister, Michael, Jenkins, Mark A, Keku, Temitope O, Kweon, Sun-Seog, Larsson, Susanna C, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Martín, Vicente, Milne, Roger L, Moreno, Victor, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A, Offit, Kenneth, Pharoah, Paul DP, Platz, Elizabeth A, Potter, John D, Qi, Lihong, Rennert, Gad, Sakoda, Lori C, Schafmayer, Clemens, Slattery, Martha L, Snetselaar, Linda, Schenk, Jeanette, Thibodeau, Stephen N, Ulrich, Cornelia M, Van Guelpen, Bethany, Harlid, Sophia, Visvanathan, Kala, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Zheng, Wei, Bueno-de-Mesquita, Bas, Boutron-Ruault, Marie-Christine, Hughes, David J, Jakszyn, Paula, Kühn, Tilman, Palli, Domenico, Riboli, Elio, Giovannucci, Edward L, Banbury, Barbara L, Gruber, Stephen B, Peters, Ulrike, Gunter, Marc J, and on behalf of GECCO, CORECT

Subjects
Complementary and Integrative Health, Digestive Diseases, Clinical Research, Clinical Trials and Supportive Activities, Cancer, Colo-Rectal Cancer, Prevention, Nutrition, Prevention of disease and conditions, and promotion of well-being, 3.3 Nutrition and chemoprevention, Case-Control Studies, Colorectal Neoplasms, Dietary Supplements, Genetic Predisposition to Disease, Humans, Mendelian Randomization Analysis, Micronutrients, Risk Factors, Selenium, Vitamin B 12, White People, Mendelian randomization, genes, nutrition, supplements, colorectal cancer, Engineering, Medical and Health Sciences, Nutrition & Dietetics
Abstract

BackgroundThe literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.ObjectivesTo complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR).MethodsTwo-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.ResultsNominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentration and higher risk of colorectal cancer (ORSD: 1.12; 95% CI: 1.03, 1.21; P value = 0.01) and similarly for colon cancer. A nominally significant association was also noted for genetically predicted selenium concentration and lower risk of colon cancer (ORSD: 0.98; 95% CI: 0.96, 1.00; P value = 0.05) and similarly for distal colon cancer. These associations were robust to sensitivity analyses. Nominally significant inverse associations were observed for zinc and risk of colorectal and distal colon cancers, but sensitivity analyses could not be performed. None of these findings survived correction for multiple testing. Genetically predicted concentrations of β-carotene, calcium, copper, folate, magnesium, phosphorus, and vitamin B-6 were not associated with disease risk.ConclusionsThese results suggest possible causal associations of circulating iron and vitamin B-12 (positively) and selenium (inversely) with risk of colon cancer.

Published
2021

17. Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts

Author

Visvanathan, Kala, Mondul, Alison M., Zeleniuch-Jacquotte, Anne, Wang, Molin, Gail, Mitchell H., Yaun, Shiaw-Shyuan, Weinstein, Stephanie J., McCullough, Marjorie L., Eliassen, A. Heather, Cook, Nancy R., Agnoli, Claudia, Almquist, Martin, Black, Amanda, Buring, Julie E., Chen, Chu, Chen, Yu, Clendenen, Tess, Dossus, Laure, Fedirko, Veronika, Gierach, Gretchen L., Giovannucci, Edward L., Goodman, Gary E., Goodman, Marc T., Guénel, Pascal, Hallmans, Göran, Hankinson, Susan E., Horst, Ronald L., Hou, Tao, Huang, Wen-Yi, Jones, Michael E., Joshu, Corrine E., Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kvaskoff, Marina, Lee, I-Min, Mahamat-Saleh, Yahya, Malm, Johan, Manjer, Jonas, Maskarinec, Gertraud, Millen, Amy E., Mukhtar, Toqir K., Neuhouser, Marian L., Robsahm, Trude E., Schoemaker, Minouk J., Sieri, Sabina, Sund, Malin, Swerdlow, Anthony J., Thomson, Cynthia A., Ursin, Giske, Wactawski-Wende, Jean, Wang, Ying, Wilkens, Lynne R., Wu, Yujie, Zoltick, Emilie, Willett, Walter C., Smith-Warner, Stephanie A., and Ziegler, Regina G.

Published
2023
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19. Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society

Author

Kroke, Anja, Schmidt, Annemarie, Amini, Anna M., Kalotai, Nicole, Lehmann, Andreas, Haardt, Julia, Bauer, Jürgen M., Bischoff-Ferrari, Heike A., Boeing, Heiner, Egert, Sarah, Ellinger, Sabine, Kühn, Tilman, Louis, Sandrine, Lorkowski, Stefan, Nimptsch, Katharina, Remer, Thomas, Schulze, Matthias B., Siener, Roswitha, Stangl, Gabriele I., Volkert, Dorothee, Zittermann, Armin, Buyken, Anette E., Watzl, Bernhard, and Schwingshackl, Lukas

Published
2022
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22. Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

Author

Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.

Published
2022
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23. Health aspects of vegan diets among children and adolescents: a systematic review and meta-analyses.

Author

Koller, Alina, Rohrmann, Sabine, Wakolbinger, Maria, Gojda, Jan, Selinger, Eliška, Cahova, Monika, Světnička, Martin, Haider, Sandra, Schlesinger, Sabrina, Kühn, Tilman, and Keller, Jeffrey W.

Abstract

Health effects of vegan diets among children and adolescents are a controversial public health topic. Thus, the aim of the present systematic review is to evaluate a broad range of health outcomes among vegan children and adolescents aged 0 to 18 years. 18 studies met the inclusion criteria (17 cross-sectional, 1 RCT). Meta-analyses showed lower protein, calcium, vitamin B2, saturated fatty acid, and cholesterol intakes, and lower ferritin, HDL and LDL levels as well as height in vegan compared to omnivorous children/adolescents. Higher intakes of carbohydrates, polyunsaturated fatty acids, fiber, folate, vitamins C and E, magnesium, iron, and potassium were observed in vegans. Blood levels of vitamin B12 were higher among vegan children due to supplement use. Single study results suggested further differences between vegan and non-vegan children, such as lower bone mineral content or urinary iodine among vegan children. Risk of Bias was rated as high or very high in 7 out of 18 studies. The certainty of evidence for the meta-analyses was low (n = 2) or very low (n = 46). Overall, the available evidence points to both risks and benefits associated with a vegan diet among children, although more and better designed studies are needed. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study

Author

Iglesias-Vázquez, Lucía, Arija, Victoria, Aranda, Núria, Aglago, Elom K., Cross, Amanda J., Schulze, Matthias B., Quintana Pacheco, Daniel, Kühn, Tilman, Weiderpass, Elisabete, Tumino, Rosario, Redondo-Sánchez, Daniel, de Magistris, Maria Santucci, Palli, Domenico, Ardanaz, Eva, Laouali, Nasser, Sonestedt, Emily, Drake, Isabel, Rizzolo, Lucía, Santiuste, Carmen, Sacerdote, Carlotta, Quirós, Ramón, Amiano, Pilar, Agudo, Antonio, and Jakszyn, Paula

Published
2022
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26. Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial

Author

Sowah, Solomon A., Milanese, Alessio, Schübel, Ruth, Wirbel, Jakob, Kartal, Ece, Johnson, Theron S., Hirche, Frank, Grafetstätter, Mirja, Nonnenmacher, Tobias, Kirsten, Romy, López-Nogueroles, Marina, Lahoz, Agustín, Schwarz, Kathrin V., Okun, Jürgen G., Ulrich, Cornelia M., Nattenmüller, Johanna, von Eckardstein, Arnold, Müller, Daniel, Stangl, Gabriele I., Kaaks, Rudolf, Kühn, Tilman, and Zeller, Georg

Published
2022
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28. Co-benefits from sustainable dietary shifts for population and environmental health: an assessment from a large European cohort study

Author

Laine, Jessica E, Huybrechts, Inge, Gunter, Marc J, Ferrari, Pietro, Weiderpass, Elisabete, Tsilidis, Kostas, Aune, Dagfinn, Schulze, Matthias B, Bergmann, Manuela, Temme, Elisabeth H M, Boer, Jolanda M A, Agnoli, Claudia, Ericson, Ulrika, Stubbendorff, Anna, Ibsen, Daniel B, Dahm, Christina Catherine, Deschasaux, Mélanie, Touvier, Mathilde, Kesse-Guyot, Emmanuelle, Sánchez Pérez, Maria-Jose, Rodríguez Barranco, Miguel, Tong, Tammy Y N, Papier, Keren, Knuppel, Anika, Boutron-Ruault, Marie-Christine, Mancini, Francesca, Severi, Gianluca, Srour, Bernard, Kühn, Tilman, Masala, Giovanna, Agudo, Antonio, Skeie, Guri, Rylander, Charlotta, Sandanger, Torkjel M, Riboli, Elio, and Vineis, Paolo

Published
2021
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30. Neubewertung der DGE-Position zu veganer Ernährung - Positionspapier der Deutschen Gesellschaft für Ernährung e.V. (DGE)

Author

Klug, Alessa, Barbaresko, Janett, Alexy, Ute, Kühn, Tilman, Kroke, Anja, Lotze-Campen, Hermann, Nöthlings, Ute, Richter, Margit, Schader, Christian, Schlesinger, Sabrina, Virmani, Kiran, Conrad, Johanna, Watzl, Bernhard, Klug, Alessa, Barbaresko, Janett, Alexy, Ute, Kühn, Tilman, Kroke, Anja, Lotze-Campen, Hermann, Nöthlings, Ute, Richter, Margit, Schader, Christian, Schlesinger, Sabrina, Virmani, Kiran, Conrad, Johanna, and Watzl, Bernhard

Abstract

In diesem Positionspapier zur Neubewertung der DGE-Position zu veganer Ernährung werden neben neuen Daten zur Gesundheit auch die weiteren Zieldimensionen einer nachhaltigeren Ernährung (Umwelt, Tierwohl und Soziales) betrachtet. Zur Identifizierung relevanter Publikationen wurden ein Umbrella Review und ein ergänzendes systematisches Review durchgeführt sowie weitere Publikationen berücksichtigt. Die Betrachtung der Zieldimensionen Tierwohl und Soziales zeigt, dass die bisherigen Ansätze zur Bewertung der Auswirkung von Ernährungsweisen in diesem Zusammenhang noch nicht ausreichend etabliert sind und nicht umfassend angewendet werden. Daher werden nur die Zieldimensionen Gesundheit und Umwelt in die Position einbezogen. Gegenüber anderen Ernährungsweisen wurden bei einer veganen Ernährung potenzielle Vor- und Nachteile für die Gesundheit identifiziert. Für die gesunde erwachsene Allgemeinbevölkerung kann neben anderen Ernährungsweisen auch eine vegane Ernährung, unter der Voraussetzung der Einnahme eines Vitamin-B12-Präparats, einer ausgewogenen, gut geplanten Lebensmittelauswahl sowie einer bedarfsdeckenden Zufuhr der potenziell kritischen Nährstoffe (ggf. auch durch weitere Nährstoffpräparate) eine gesundheitsfördernde Ernährung darstellen. Für die vulnerablen Gruppen Kinder, Jugendliche, Schwangere, Stillende und Senior*innen kann die DGE aufgrund der weiterhin eingeschränkten Datenlage weder eine eindeutige Empfehlung für noch gegen eine vegane Ernährung aussprechen. Aufgrund des Risikos für potenzielle, teilweise irreversible Konsequenzen bei inadäquater Durchführung müssen für eine vegane Ernährung in vulnerablen Gruppen besonders fundierte Ernährungskompetenzen vorliegen. Eine Ernährungsberatung durch qualifizierte Fachkräfte ist daher für diese Gruppen dringend angeraten. Eine vegane Ernährung ist als äußerst umweltfreundlich anzusehen, sie stellt eine empfehlenswerte Maßnahme zur Verringerung der Umweltbelastungen des Ernährungssystems dar. Unter Berücksic

Published
2024

31. Correction to: Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort (European Journal of Nutrition, (2016), 55, 1, (7-20), 10.1007/s00394-014-0818-5)

Author

MS MDL 1, Hart- en Vaatziekten Team A, Stepien, Magdalena, Duarte-Salles, Talita, Fedirko, Veronika, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Klinaki, Eleni, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Naccarati, Alessio, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Parr, Christine L., Quirós, José Ramón, Buckland, Genevieve, Molina-Montes, Esther, Amiano, Pilar, Chirlaque, Maria Dolores, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Wennberg, Maria, Nilsson, Lena Maria, Khaw, Kay Tee, Wareham, Nick, Bradbury, Kathryn E., Ward, Heather A., Romieu, Isabelle, Jenab, Mazda, MS MDL 1, Hart- en Vaatziekten Team A, Stepien, Magdalena, Duarte-Salles, Talita, Fedirko, Veronika, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Klinaki, Eleni, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Naccarati, Alessio, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Parr, Christine L., Quirós, José Ramón, Buckland, Genevieve, Molina-Montes, Esther, Amiano, Pilar, Chirlaque, Maria Dolores, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Wennberg, Maria, Nilsson, Lena Maria, Khaw, Kay Tee, Wareham, Nick, Bradbury, Kathryn E., Ward, Heather A., Romieu, Isabelle, and Jenab, Mazda

Published
2024

33. Stenosi del capezzolo in una vacca da carne.

Author

Schären-Bannert, Melanie, Starke, Alexander, Snedec, Teja, Vogel, Laura, Wagner, Romy, Kühn, Tilman, and Bittner-Schwerda, Lilli

Abstract

Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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34. Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort

Author

Aglago, Elom K., Huybrechts, Inge, Murphy, Neil, Casagrande, Corinne, Nicolas, Genevieve, Pischon, Tobias, Fedirko, Veronika, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Fournier, Agnès, Katzke, Verena, Kühn, Tilman, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José Maria, Ardanaz, Eva, Perez-Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Bueno-de-Mesquita, Bas, May, Anne, Derksen, Jeroen W.G., Hellstrand, Sophie, Ohlsson, Bodil, Wennberg, Maria, Van Guelpen, Bethany, Skeie, Guri, Brustad, Magritt, Weiderpass, Elisabete, Cross, Amanda J., Ward, Heather, Riboli, Elio, Norat, Teresa, Chajes, Veronique, and Gunter, Marc J.

Published
2020
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36. Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Author

Molina‐Montes, Esther, Sánchez, María‐José, Zamora‐Ros, Raul, Bueno‐de‐Mesquita, HB, Wark, Petra A, Obon‐Santacana, Mireia, Kühn, Tilman, Katzke, Verena, Travis, Ruth C, Ye, Weimin, Sund, Malin, Naccarati, Alessio, Mattiello, Amalia, Krogh, Vittorio, Martorana, Caterina, Masala, Giovanna, Amiano, Pilar, Huerta, José‐María, Barricarte, Aurelio, Quirós, José‐Ramón, Weiderpass, Elisabete, Åsli, Lene Angell, Skeie, Guri, Ericson, Ulrika, Sonestedt, Emily, Peeters, Petra H, Romieu, Isabelle, Scalbert, Augustin, Overvad, Kim, Clemens, Matthias, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Vidalis, Pavlos, Khaw, Kay‐Tee, Wareham, Nick, Olsen, Anja, Tjønneland, Anne, Boutroun‐Rualt, Marie‐Christine, Clavel‐Chapelon, Françoise, Cross, Amanda J, Lu, Yunxia, Riboli, Elio, and Duell, Eric J

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Digestive Diseases, Nutrition, Pancreatic Cancer, Rare Diseases, Complementary and Integrative Health, Cancer, Prevention, Cohort Studies, Diet, Diet Records, Europe, Female, Flavonoids, Humans, Life Style, Lignans, Male, Middle Aged, Pancreatic Neoplasms, Proportional Hazards Models, Prospective Studies, cohort, diet, flavonoids, lignans, pancreatic cancer, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

Published
2016

37. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Freisling, Heinz, Pisa, Pedro T, Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C, Vergnaud, Anne-Claire, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P, Quirós, J Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J, Romaguera, Dora, Lu, Yunxia, Lassale, Camille M, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H Bas, Ocké, Marga C, Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra HM, and Slimani, Nadia

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Clinical Research, Prevention, Nutrition, Metabolic and endocrine, Adult, Aged, Ascorbic Acid, Calcium, Dietary, Diet, Dietary Fiber, Dietary Proteins, Europe, Female, Folic Acid, Follow-Up Studies, Humans, Linear Models, Male, Middle Aged, Nutrition Assessment, Phosphorus, Dietary, Prospective Studies, Riboflavin, Surveys and Questionnaires, Weight Gain, beta Carotene, Dietary patterns, Energy balance, Nutrients, Obesity, Public health, Weight gain, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract

PurposeVarious food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.MethodsThis study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.ResultsMean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant.ConclusionsWe identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.

Published
2016

38. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A, Hémon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Förster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra HM, Bueno-de-Mesquita, H Bas, Engeset, Dagrun, Skeie, Guri, Hjartåker, Anette, Menéndez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Huerta, José María, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J, Khaw, Kay-Thee, Wareham, Nicholas J, Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, and Scalbert, Augustin

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Complementary and Integrative Health, Nutrition, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Cancer, Adult, Aged, Body Mass Index, Coffee, Cross-Sectional Studies, Diet, Europe, Exercise, Female, Flavonoids, Food Analysis, Food Handling, Fruit, Humans, Hydroxybenzoates, Life Style, Male, Mental Recall, Middle Aged, Nutrition Assessment, Polyphenols, Proanthocyanidins, Prospective Studies, Socioeconomic Factors, Tea, Dietary intake, EPIC, Food sources, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract

Background/objectivesPolyphenols are plant secondary metabolites with a large variability in their chemical structure and dietary occurrence that have been associated with some protective effects against several chronic diseases. To date, limited data exist on intake of polyphenols in populations. The current cross-sectional analysis aimed at estimating dietary intakes of all currently known individual polyphenols and total intake per class and subclass, and to identify their main food sources in the European Prospective Investigation into Cancer and Nutrition cohort.MethodsDietary data at baseline were collected using a standardized 24-h dietary recall software administered to 36,037 adult subjects. Dietary data were linked with Phenol-Explorer, a database with data on 502 individual polyphenols in 452 foods and data on polyphenol losses due to cooking and food processing.ResultsMean total polyphenol intake was the highest in Aarhus-Denmark (1786 mg/day in men and 1626 mg/day in women) and the lowest in Greece (744 mg/day in men and 584 mg/day in women). When dividing the subjects into three regions, the highest intake of total polyphenols was observed in the UK health-conscious group, followed by non-Mediterranean (non-MED) and MED countries. The main polyphenol contributors were phenolic acids (52.5-56.9 %), except in men from MED countries and in the UK health-conscious group where they were flavonoids (49.1-61.7 %). Coffee, tea, and fruits were the most important food sources of total polyphenols. A total of 437 different individual polyphenols were consumed, including 94 consumed at a level >1 mg/day. The most abundant ones were the caffeoylquinic acids and the proanthocyanidin oligomers and polymers.ConclusionThis study describes the large number of dietary individual polyphenols consumed and the high variability of their intakes between European populations, particularly between MED and non-MED countries.

Published
2016

40. Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)

Author

Mahamat-Saleh, Yahya, Cervenka, Iris, Al-Rahmoun, Marie, Mancini, Francesca R., Severi, Gianluca, Ghiasvand, Reza, Veierod, Marit B., Caini, Saverio, Palli, Domenico, Botteri, Edoardo, Sacerdote, Carlotta, Ricceri, Fulvio, Trichopoulou, Antonia, Peppa, Eleni, La Vecchia, Carlo, Overvad, Kim, Dahm, Christina C., Olsen, Anja, Tjønneland, Anne, Perez-Cornago, Aurora, Jakszyn, Paula, Grioni, Sara, Schulze, Matthias B., Skeie, Guri, Lasheras, Cristina, Colorado-Yohar, Sandra, Rodríguez-Barranco, Miguel, Kühn, Tilman, Katzke, Verena A., Amiano, Pilar, Tumino, Rosario, Panico, Salvatore, Ezponda, Ana, Sonestedt, Emily, Scalbert, Augustin, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, and Kvaskoff, Marina

Published
2020
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41. A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Author

Papadimitriou, Nikos, Muller, David, van den Brandt, Piet A., Geybels, Milan, Patel, Chirag J., Gunter, Marc J., Lopez, David S., Key, Timothy J., Perez-Cornago, Aurora, Ferrari, Pietro, Vineis, Paolo, Weiderpass, Elisabete, Boeing, Heiner, Agudo, Antonio, Sánchez, María-José, Overvad, Kim, Kühn, Tilman, Fortner, Renee T., Palli, Domenico, Drake, Isabel, Bjartell, Anders, Santiuste, Carmen, Bueno-de-Mesquita, Bas H., Krogh, Vittorio, Tjønneland, Anne, Lauritzen, Dorthe Furstrand, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Stattin, Pär, Trichopoulou, Antonia, Martimianaki, Georgia, Karakatsani, Anna, Thysell, Elin, Johansson, Ingegerd, Ricceri, Fulvio, Tumino, Rosario, Larrañaga, Nerea, Khaw, Kay Tee, Riboli, Elio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K.

Published
2020
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42. Correlations between urinary concentrations and dietary intakes of flavonols in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Garro-Aguilar, Yaiza, Cayssials, Valerie, Achaintre, David, Boeing, Heiner, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine, Kühn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Karakatsani, Anna, Thriskos, Paschalis, Masala, Giovanna, Grioni, Sara, Santucci de Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Huybrechts, Inge, Agudo, Antonio, Scalbert, Augustin, and Zamora-Ros, Raul

Published
2020
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43. Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Author

Solans, Marta, Benavente, Yolanda, Saez, Marc, Agudo, Antonio, Jakszyn, Paula, Naudin, Sabine, Hosnijeh, Fatemeh Saberi, Gunter, Marc, Huybrechts, Inge, Ferrari, Pietro, Besson, Caroline, Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Lasheras, Cristina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María Dolores, Ardanaz, Eva, Schmidt, Julie A., Vineis, Paolo, Riboli, Elio, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elisavet, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Skeie, Guri, Weiderpass, Elisabete, Jerkeman, Mats, Dias, Joana Alves, Späth, Florentin, Nilsson, Lena Maria, Dahm, Christina C., Overvad, Kim, Petersen, Kristina Elin Nielsen, Tjønneland, Anne, de Sanjose, Silvia, Vermeulen, Roel, Nieters, Alexandra, and Casabonne, Delphine

Published
2020
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44. Autoimmunity plays a role in the onset of diabetes after 40 years of age

Author

Rolandsson, Olov, Hampe, Christiane S., Sharp, Stephen J., Ardanaz, Eva, Boeing, Heiner, Fagherazzi, Guy, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Gunter, Marc J., Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Krogh, Vittorio, Kühn, Tilman, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Sánchez, Maria-José, Severi, Gianluca, Spijkerman, Annemieke M. W., Tumino, Rosario, van der Schouw, Yvonne T., Riboli, Elio, Forouhi, Nita G., Langenberg, Claudia, and Wareham, Nicholas J.

Published
2020
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45. Body iron status and gastric cancer risk in the EURGAST study

Author

Fonseca-Nunes, Ana, Agudo, Antonio, Aranda, Núria, Arija, Victoria, Cross, Amanda J, Molina, Esther, Sanchez, Maria Jose, Bueno-de-Mesquita, HB As, Siersema, Peter, Weiderpass, Elisabete, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Saieva, Calogero, Naccarati, Alessio, Ohlsson, Bodil, Sjöberg, Klas, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Fagherazzi, Guy, Boeing, Heiner, Steffen, Annika, Kühn, Tilman, Katzke, Verena, Tjønneland, Anne, Olsen, Anja, Khaw, Kay-Tee, Wareham, Nick, Key, Tim, Lu, Yunxia, Riboli, Elio, Peeters, Petra H, Gavrila, Diana, Dorronsoro, Miren, Quirós, José Ramón, Barricarte, Aurelio, Jenab, Mazda, Zamora-Ros, Raúl, Freisling, Heinz, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, and Jakszyn, Paula

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Oncology and Carcinogenesis, Clinical Research, Digestive Diseases, Nutrition, Rare Diseases, Prevention, Cancer, 2.1 Biological and endogenous factors, Aetiology, Adenocarcinoma, Case-Control Studies, Ferritins, Humans, Iron, Risk Factors, Stomach Neoplasms, gastric cancer, iron homeostasis, nested case-control study, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2  = 0.80, 95% CI = 0.72-0.88; OR10%increment  = 0.87, 95% CI = 0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity = 0.04 and TS had a p for heterogeneity = 0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl  = 1.13, 95% CI = 1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity = 0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify the role of iron in gastric carcinogenesis.

Published
2015

46. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author

Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-de-Mesquita, HB As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Quirós, J Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay-Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Hepatitis, Infectious Diseases, Hepatitis - B, Liver Cancer, Prevention, Liver Disease, Cancer, Chronic Liver Disease and Cirrhosis, Rare Diseases, Nutrition, Digestive Diseases, Clinical Research, Emerging Infectious Diseases, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Adult, Aged, Carcinoma, Hepatocellular, Case-Control Studies, Diet, Dietary Fats, Europe, Feeding Behavior, Female, Humans, Incidence, Life Style, Liver Neoplasms, Male, Middle Aged, Nutritional Status, Prospective Studies, Risk, Risk Factors, Surveys and Questionnaires, Young Adult, European populations, cohort study, dietary fats, hepatocellular carcinoma, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.

Published
2015

47. A Prospective Study of the Immune System Activation Biomarker Neopterin and Colorectal Cancer Risk

Author

Aleksandrova, Krasimira, Chuang, Shu-Chun, Boeing, Heiner, Zuo, Hui, Tell, Grethe S, Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, Bas, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Fedirko, Veronika, Johansson, Mattias, Weiderpass, Elisabete, Severi, Gianluca, Racine, Antoine, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Kühn, Tilman, Tjønneland, Anne, Overvad, Kim, Quirós, J Ramón, Jakszyn, Paula, Sánchez, María-José, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, May, Anne M, Palmqvist, Richard, Ljuslinder, Ingrid, Kong, So Yeon J, Freisling, Heinz, Gunter, Marc J, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, and Vineis, Paolo

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Colo-Rectal Cancer, Cancer, Clinical Research, Digestive Diseases, Adult, Aged, Biomarkers, Tumor, Case-Control Studies, Chromatography, Liquid, Colonic Neoplasms, Colorectal Neoplasms, Europe, Female, Humans, Immunity, Cellular, Male, Middle Aged, Neopterin, Odds Ratio, Prospective Studies, Rectal Neoplasms, Sensitivity and Specificity, T-Lymphocytes, Helper-Inducer, Tandem Mass Spectrometry, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference = .87) and after excluding case patients diagnosed within the first four follow-up years. These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.

Published
2015

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