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Introduction/Background Intra-operative frozen section (IFS) can provide an instinct guide for treatment of ovarian tumors intra-operatively, though limitations exist. We aimed to determine the value of IFS and US in the diagnosis of ovarian granulosa cell tumors. Methodology A retrospective review of granulosa cell tumors (GCTs) surgically treated at our Unit, between June 2006 and March 2019, was done. The diagnostic performance of ultrasound (US) and malignant IFS diagnosis was evaluated. Data of 20 patients were reviewed. Intra-operative FS and US results were compared with the definitive surgical diagnosis. Surgical data were reviewed and analyzed. Results A total of 12 cases were correctly identified at the intraoperative FS as ovarian granulosa tumors. There were 8 (32%) false negative diagnoses. According to well defined parameters, all 20 cases were correctly suspected as ovarian GCTs at US. About surgical treatment, in 12 women with positive FS the appropriate surgical staging was performed. In 8 women with negative FS surgical treatment was variable: 4 women underwent laparoscopic salpingo-oophorectomy and the surgical staging was completed after definitive surgical diagnosis; hysterectomy and bilateral salpingo-oophorectomy was performed in 2 patients; the conservative surgery on the healthy ovary was performed in the remaining 2 patients. Conclusion This study concluded that FS appears to be an inadequate technique for the histopathological diagnosis of ovarian GCTs, while the US features are really suggestive allowing a right clinical suspicious. Perhaps, when an ovarian GCTs is suspected at the US, intraoperative FS could be misleading and could lead to an inappropriate surgical management. Disclosure Nothing to disclose.

Made available in DSpace on 2022-04-28T20:55:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-01-01 In this paper, we propose a statistic procedure for estimating theamount of alumina incorporated in aparticulated metal matrix compositesynthesized by the stir casting methodComposite specimens, consisting of A356AI alloy matrix material containing 5 wt°/o ofalumina particles, were prepared using thecompocast- ing technique. An intermediatetraversal section of each composite ingotwas stratified into 24 parts and thevolumetric fraction of alumina wasmeasured by image analysis at 279separate points to study the aluminadistribution in the material. Alumina particledistribution was observed to haveconsiderable heterogeneity. Thestratification technique employed in thisstudy permits an ideal trade-off between theaccuracy of the estimated alumina and therequired measurement labor. © CarlHanser Verlag, München. Department of Materials and Technology São Paulo State University (UNESP), Av. Dr. Ariberto Pereira da Cunha,333, Guaratinguetä, SP 12.516-410 Production Department Säo Paulo State University (UNESP), Av. Dr. Ariberto Pereira da Cunha,333, Guaratinguetá, SP 12.516-410 Department of Materials and Technology São Paulo State University (UNESP), Av. Dr. Ariberto Pereira da Cunha,333, Guaratinguetä, SP 12.516-410 Production Department Säo Paulo State University (UNESP), Av. Dr. Ariberto Pereira da Cunha,333, Guaratinguetá, SP 12.516-410

BACKGROUND: Despite significant differences in age of onset and incidence of breast cancer between Caucasian (CA), African-American (AA) and Korean (KO) women, little is known about differences in BRCA1/2 mutations in these populations. The purpose of this study is to evaluate the prevalence of BRCA1/2 mutations and the association between BRCA1/2 mutation status and secondary malignancies among young women with breast cancer in these three racially diverse groups. METHODS: Patients presenting to our breast cancer follow-up clinics selected solely on having a known breast cancer diagnosis at a young age (YBC defined as age