Search

We present the results from a dense multi-wavelength (optical/UV, near-infrared (IR), and X-ray) follow-up campaign of the nuclear transient AT2017gge, covering a total of 1698 days from the transient's discovery. The bolometric lightcurve, the black body temperature and radius, the broad H and He I $\lambda$5876 emission lines and their evolution with time, are all consistent with a tidal disruption event (TDE) nature. A soft X-ray flare is detected with a delay of $\sim$200 days with respect to the optical/UV peak and it is rapidly followed by the emergence of a broad He II $\lambda$4686 and by a number of long-lasting high ionization coronal emission lines. This indicate a clear connection between a TDE flare and the appearance of extreme coronal line emission (ECLEs). An IR echo, resulting from dust re-radiation of the optical/UV TDE light is observed after the X-ray flare and the associated near-IR spectra show a transient broad feature in correspondence of the He I $\lambda$10830 and, for the first time in a TDE, a transient high-ionization coronal NIR line (the [Fe XIII] $\lambda$10798) is also detected. The data are well explained by a scenario in which a TDE occurs in a gas and dust rich environment and its optical/UV, soft X-ray, and IR emission have different origins and locations. The optical emission may be produced by stellar debris stream collisions prior to the accretion disk formation, which is instead responsible for the soft X-ray flare, emitted after the end of the circularization process., Comment: Accepted for publication in MNRAS

We analyze the MOA-2020-BLG-208 gravitational microlensing event and present the discovery and characterization of a new planet, MOA-2020-BLG-208Lb, with an estimated sub-Saturn mass. With a mass ratio q = 3.17 − 0.26 + 0.28 × 10 − 4 , the planet lies near the peak of the mass-ratio function derived by the MOA collaboration and near the edge of expected sample sensitivity. For these estimates we provide results using two mass-law priors: one assuming that all stars have an equal planet-hosting probability, and the other assuming that planets are more likely to orbit around more massive stars. In the first scenario, we estimate that the lens system is likely to be a planet of mass m planet = 46 − 24 + 42 M ⊕ and a host star of mass M host = 0.43 − 0.23 + 0.39 M ⊙ , located at a distance D L = 7.49 − 1.13 + 0.99 kpc . For the second scenario, we estimate m planet = 69 − 34 + 37 M ⊕ , M host = 0.66 − 0.32 + 0.35 M ⊙ , and D L = 7.81 − 0.93 + 0.93 kpc . The planet has a projected separation as a fraction of the Einstein ring radius s = 1.3807 − 0.0018 + 0.0018 . As a cool sub-Saturn-mass planet, this planet adds to a growing collection of evidence for revised planetary formation models.

Context: The timescale of a microlensing event scales as a square root of a lens mass. Therefore, long-lasting events are important candidates for massive lenses, including black holes. Aims: Here we present the analysis of the Gaia18cbf microlensing event reported by the Gaia Science Alerts system. It exhibited a long timescale and features that are common for the annual microlensing parallax effect. We deduce the parameters of the lens based on the derived best fitting model. Methods: We used photometric data collected by the Gaia satellite as well as the follow-up data gathered by the ground-based observatories. We investigated the range of microlensing models and used them to derive the most probable mass and distance to the lens using a Galactic model as a prior. Using known mass-brightness relation we determined how likely it is that the lens is a main-sequence (MS) star. Results: This event is one of the longest ever detected, with the Einstein timescale of $t_\mathrm{E}=491.41^{+128.31}_{-84.94}$ days for the best solution and $t_\mathrm{E}=453.74^{+178.69}_{-105.74}$ days for the second-best. Assuming Galaxy priors, this translates to the most probable lens mass of $M_\mathrm{L} = 2.65^{+5.09}_{-1.48} M_\odot$ and $M_\mathrm{L} = 1.71^{+3.78}_{-1.06} M_\odot$, respectively. The limits on the blended light suggest that this event was most likely not caused by a MS star, but rather by a dark remnant of stellar evolution., Comment: accepted by Astonomy&Astrophysics, 12 pages, 5 figures

We present the photometric analysis of Gaia19bld, a high-magnification ($A\approx60$) microlensing event located in the southern Galactic plane, which exhibited finite source and microlensing parallax effects. Due to a prompt detection by the Gaia satellite and the very high brightness of $I = 9.05~$mag at the peak, it was possible to collect a complete and unique set of multi-channel follow-up observations, which allowed us to determine all parameters vital for the characterisation of the lens and the source in the microlensing event. Gaia19bld was discovered by the Gaia satellite and was subsequently intensively followed up with a network of ground-based observatories and the Spitzer Space Telescope. We collected multiple high-resolution spectra with Very Large Telescope (VLT)/X-Shooter to characterise the source star. The event was also observed with VLT Interferometer (VLTI)/PIONIER during the peak. Here we focus on the photometric observations and model the light curve composed of data from Gaia, Spitzer, and multiple optical, ground-based observatories. We find the best-fitting solution with parallax and finite source effects. We derived the limit on the luminosity of the lens based on the blended light model and spectroscopic distance. We compute the mass of the lens to be $1.13 \pm 0.03~M_{\odot}$ and derive its distance to be $5.52^{+0.35}_{-0.64}~\mathrm{kpc}$. The lens is likely a main sequence star, however its true nature has yet to be verified by future high-resolution observations. Our results are consistent with interferometric measurements of the angular Einstein radius, emphasising that interferometry can be a new channel for determining the masses of objects that would otherwise remain undetectable, including stellar-mass black holes., Comment: accepted to Astronomy&Astrophysics

We present the most extensive and detailed reddening maps of the Magellanic Clouds (MCs) derived from the color properties of Red Clump (RC) stars. The analysis is based on the deep photometric maps from the fourth phase of the Optical Gravitational Lensing Experiment (OGLE-IV), covering approximately 670 deg2 of the sky in the Magellanic System region. The resulting maps provide reddening information for 180 deg2 in the Large Magellanic Cloud (LMC) and 75 deg2 in the Small Magellanic Cloud (SMC), with a resolution of 1.7x1.7 arcmin in the central parts of the MCs, decreasing to approximately 27x27 arcmin in the outskirts. The mean reddening is E(V-I) = 0.100 +- 0.043 mag in the LMC and E(V-I) = 0.047 +- 0.025 mag in the SMC. We refine methods of calculating the RC color to obtain the highest possible accuracy of reddening maps based on RC stars. Using spectroscopy of red giants, we find the metallicity gradient in both MCs, which causes a slight decrease of the intrinsic RC color with distance from the galaxy center of ~0.002 mag/deg in the LMC and between 0.003 and 0.009 mag/deg in the SMC. The central values of the intrinsic RC color are 0.886 and 0.877 mag in the LMC and SMC, respectively. The reddening map of the MCs is available on-line both in the downloadable form and as an interactive interface., Comment: 22 pages, 21 figures, 1 table; accepted by ApJS; online data available at: http://ogle.astrouw.edu.pl/cgi-ogle/get_ms_ext.py significant improvements compared to the previous version

Due to their scarcity, microlensing events in the Galactic disk are of great interest and high-cadence photometric observations, supplemented by spectroscopic follow-up, are necessary for constraining the physical parameters of the lensing system. In particular, a precise estimate of the source characteristics is required to accurately measure the lens distance and mass. We conducted a spectroscopic follow-up of microlensing event Gaia19bld to derive the properties of the microlensing source and, ultimately, to estimate the mass and distance of the lens. We obtained low- and high-resolution spectroscopy from multiple sites around the world during the course of the event. The spectral lines and template matching analysis has led to two independent, consistent characterizations of the source. We found that the source is a red giant located at about 8.5 kpc from the Earth. Combining our results with the photometric analysis has led to a lens mass of Ml=1.1 M at a distance of D l = 5.5 kpc. We did not find any significant blend light in the spectra (with an upper detection limit of V < 17 mag), which is in agreement with photometric observations. Therefore, we cannot exclude the possibility that the lens is a main-sequence star. Indeed, we predict in this scenario a lens brightness of V about 20 mag, a value that would make it much fainter than the detection limit., A&A in press

As shown by recent gravitational wave detections, galaxies harbour an unknown population of black holes at high masses. In our Galaxy such dark objects can be found and studied solely via gravitational microlensing methods. This paper described our search for black-hole lenses both in archived OGLE data and among on-going microlensing events found by OGLE and Gaia. That combination of superb time-domain astrometry and photometry will enable us to derive masses and distances to these dark lenses uniquely, and to describe the demographics of the unseen component of the Milky Way.

著者人数: Leading authors 13名, The KMTNet Collaboration 18名, The OGLE Collaboration 11名, The MOA Collaboration 22名, The CFHT Collaboration 5名, The UKIRT Microlensing Team 7名, 全66名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 鈴木, 大介), Number of authors: Leading authors 13, The KMTNet Collaboration 18, The OGLE Collaboration 11, The MOA Collaboration 22, The CFHT Collaboration 5, The UKIRT Microlensing Team 7, Total 66 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Suzuki, Daisuke), Accepted: 2019-07-02, 資料番号: SA1190106000

We report the discovery of a $Spitzer$ microlensing planet OGLE-2018-BLG-0596Lb, with preferred planet-host mass ratio $q \sim 2\times10^{-4}$. The planetary signal, which is characterized by a short $(\sim 1~{\rm day})$ "bump" on the rising side of the lensing light curve, was densely covered by ground-based surveys. We find that the signal can be explained by a bright source that fully envelops the planetary caustic, i.e., a "Hollywood" geometry. Combined with the source proper motion measured from $Gaia$, the $Spitzer$ satellite parallax measurement makes it possible to precisely constrain the lens physical parameters. The preferred solution, in which the planet perturbs the minor image due to lensing by the host, yields a Uranus-mass planet with a mass of $M_{\rm p} = 13.9\pm1.6~M_{\oplus}$ orbiting a mid M-dwarf with a mass of $M_{\rm h} = 0.23\pm0.03~M_{\odot}$. There is also a second possible solution that is substantially disfavored but cannot be ruled out, for which the planet perturbs the major image. The latter solution yields $M_{\rm p} = 1.2\pm0.2~M_{\oplus}$ and $M_{\rm h} = 0.15\pm0.02~M_{\odot}$. By combining the microlensing and $Gaia$ data together with a Galactic model, we find in either case that the lens lies on the near side of the Galactic bulge at a distance $D_{\rm L} \sim 6\pm1~{\rm kpc}$. Future adaptive optics observations may decisively resolve the major image/minor image degeneracy., 34 pages, 8 figures, Submitted to AAS journal

著者人数: Leading authors 7名, The KMTNet Collaboration 20名, The MOA Collaboration 23名, The OGLE Collaboration 11名, Spitzer Microlensing Team 5名, 全66名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 鈴木, 大介), Number of authors: Leading authors 7, The KMTNet Collaboration 20, The MOA Collaboration 23, The OGLE Collaboration 11, Spitzer Microlensing Team 5, Total 66 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Suzuki, Daisuke), Accepted: 2019-04-02, 資料番号: SA1190031000

著者人数: 105名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 鈴木, 大介), Number of authors: 105 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Suzuki, Daisuke), Accepted: 2019-07-03, 資料番号: SA1190108000

Tidal Disruption Events (TDE) allow to probe the super massive black holes (SMBH) in the cores of galaxies and could be a source of black hole mass growth. We present the search for candidates for TDEs conducted within OGLE and Gaia surveys. Our preliminary results indicate that TDEs can occur in cores of galaxies exhibiting different levels of activity, from quiescent, through weak-AGNs to highly active QSOs. We also present how Gaia can help study the mass distribution of Milky Way single black holes via microlensing.

We have used deep Optical Gravitational Lensing Experiment (OGLE-IV) images ($V \lesssim 23$ mag, $I \lesssim 23$ mag at $3\sigma$) of the Magellanic System, encompassing an area of $\sim$670 deg$^2$, to perform a search for high-$z$ quasar candidates. We combined the optical OGLE data with the mid-IR Wide-field Infrared Survey Explorer (WISE) 3.4/4.6/12 $\mu$m data, and devised a multi-color selection procedure. We have identified 33 promising sources and then spectroscopically observed the two most variable ones. We report the discovery of two high-$z$ quasars, OGLE J015531-752807 at a redshift $z=5.09$ and OGLE J005907-645016 at a redshift of $z=4.98$. The variability amplitude of both quasars at the rest-frame wavelength $\sim$1300\AA\ is much larger ($\sim$0.4 mag) than other quasars ($, Comment: 9 pages, 6 figures, submitted to AAS Journals, comments welcome

著者人数: Leading authors 11名, The KMTNet Collaboration 21名, The OGLE Collaboration 11名, The MOA Collaboration 23名, 全66名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 鈴木, 大介), Number of authors: Leading authors 11, The KMTNet Collaboration 21, The OGLE Collaboration 11, The MOA Collaboration 23, Total 66 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Suzuki, Daisuke), Accepted: 2019-06-27, 資料番号: SA1190105000

In this paper, we study quantitatively the effect of the Earth's core formation on the secular rate of change of the length of day (LOD). We find that for the present epoch, a growth rate of the core comprised between 1 and 10 mm/cy seems to be a plausible guess, leading to a relative de crease of LOD comprised roughly between 10 and 100 μs/cy. Such values do not affect significantly the observed secular in crease of LOD caused by tidal braking, which amounts to about 1.79 ms/cy. However, in the remote geological past, before the Phanerozoic, the effects of core growth may have been much more important, because the total change of LOD associated with core formation has been estimated by Birch in 1965 to be 2.4 hours for an initially undifferentiated cold Earth, and 3.1 hours for an initially undifferentiated hot Earth. We consider a number of scenarios, some of them corresponding to very early and/or very fast core formation, others corresponding to slow and/or late core formation. We show that palaeo-LOD measurements seem to favour slow core formation during the Proterozoic, contrarily to the now largely prevailing hypothesis based on geochemical arguments that the iron core formed very early in the Earth's history and during a geologically short time interval (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

We analyze the combined Spitzer and ground-based data for OGLE-2017-BLG-1140 and show that the event was generated by a Jupiter-class $(m_p\simeq 1.6\,M_{\rm jup})$ planet orbiting a mid-late M dwarf $(M\simeq 0.2\,M_\odot)$ that lies $D_{LS}\simeq 1.0\,\mathrm{kpc}$ in the foreground of the microlensed, Galactic-bar, source star. The planet-host projected separation is $a_\perp \simeq 1.0\,\mathrm{au}$, i.e., well-beyond the snow line. By measuring the source proper motion ${\mathbf{\mu}}_s$ from ongoing, long-term OGLE imaging, and combining this with the lens-source relative proper motion ${\mathbf{\mu}}_\mathrm{rel}$ derived from the microlensing solution, we show that the lens proper motion ${\mathbf{\mu}}_l={\mathbf{\mu}}_\mathrm{rel} + {\mathbf{\mu}}_s$ is consistent with the lens lying in the Galactic disk, although a bulge lens is not ruled out. We show that while the Spitzer and ground-based data are comparably well fitted by planetary (i.e., binary-lens, 2L1S) models and by binary-source (1L2S) models, the combination of Spitzer and ground-based data decisively favor the planetary model. This is a new channel to resolve the 2L1S/1L2S degeneracy, which can be difficult to break in some cases., Comment: Revised version accepted for publication in The Astronomical Journal

The total flux of energy emitted by a star is a basic source of almost all physical and chemical processes in the atmosphere and on the surface of a planet. On the other hand, the upper parts of atmosphere, ionosphere, and magnetosphere are influenced to a great extent by tiny energy fluxes contained in the stellar XUV radiation and wind that are mostly responsible for ionization and photodissociation of atmospheric constituents and their escape. The latter problem is essential for the eventual detection of planets around stars. This paper demonstrates quantitatively how the above energy fluxes vary during a star's evolution. The results are presented for a solar-type star and a planet located initially at a distance of 1 AU from the star, providing insight into the past and future of the Sun and Earth. Among other things, the adopted model predicts that the maximum values of the energy flux reaching the Earth during giant phases of the Sun are greater than the respective values observed at present (the quiet Sun) by about 5 orders of magnitude for the solar wind, 3 orders of magnitude for the total radiation, and 2 orders of magnitude for the XUV radiation. On the other hand, the latter increases enormously (about 6 orders of magnitude) during a brief period of the post-asymptotic giant stage and decreases fast when moving to and during the white dwarf phase.

From recent estimates of the age of the inner core based on the theory of thermal evolution of the core, we estimate that nowadays the growth of the inner core may perhaps contribute to the observed overall secular increase of LOD caused mainly by tidal friction (i.e., 1.72 ms per century) by a relative decrease of 2 to 7 µs per century. Another, albeit much less plausible, hypothesis is that crystallization of the inner core does not produce any change of LOD, but makes the inner core rotate differentially with respect to the outer core and mantle. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

We show that the fast tidal cycling postulated by Lathe [Lathe, R., 2004. Icarus 168, 18–22] is not a plausible mechanism to explain the origin of life on Earth about 3.9 Ga ago. The value of LOD at this remote epoch was probably comprised between 15 to 17 h, and the Earth–Moon distance was only about 20% smaller than nowadays, implying that the tidal frequencies and amplitudes were not so dramatically different from the present ones as stated in Lathe's paper.

Rostral ventrolateral medulla (rVLM) and parapyramidal region (PPr) serve as important medullary control sites for sympathoexcitation. rVLM and PPr have direct projections to the intermediolateral cell column (IML) that are thought to be important in maintaining mean arterial blood pressure (MAP). Substance P (SP) is found in PPr neurons and in and near the subretrofacial area of the rVLM. At least some of these cells project to the IML. We investigated the involvement of SP at the IML in mediating rVLM- and PPr-evoked pressor responses in the chloralose-anesthetized cat. Pressor responses to electrical and chemical PPr and rVLM stimulation were altered after intrathecal injection, at the level of the T1-T3 spinal cord, of either SP antagonist [d-Pro2,d-Phe7,d-Trp9]-SP, SP antagonist CP 96,345, or SP antiserum. Although MAP and heart rate responses to PPr stimulation were attenuated by intrathecal SP antagonists or antiserum, MAP responses to rVLM stimulation were augmented. Previous studies have revealed differences in transmitters associated with these two areas, even though the general response of both areas is sympathoexcitatory. The present study implies that the identical substance may increase or decrease the MAP response depending on the pathway activated.

Although chemical stimulation of abdominal visceral afferents has been shown to reflexly increase cardiovascular and ventilatory function, the effect of stimulating these afferents on airway smooth muscle is unknown. Therefore, we recorded transverse smooth muscle tension from an innervated segment of trachea in chloralose-anesthetized dogs while we topically applied capsaicin (200 micrograms/ml) and bradykinin (0.01-10 micrograms/ml) to the serosal surfaces of the stomach, small intestine, and gallbladder. Application of these irritant substances to the stomach and small intestine decreased tracheal tension and increased mean arterial pressure. However, application of capsaicin and bradykinin to the gallbladder had only small effects on both of these variables. Cutting the splanchnic nerves abolished or greatly attenuated the decreases in tension and increases in mean arterial pressure, whereas cutting the vagi had no effect on them. We conclude that stimulation of splanchnic afferent endings in the stomach and small intestine reflexly relaxes tracheal smooth muscle in dogs. This effect may be one component of the constellation of autonomic responses reflexly evoked by abdominal visceral pain and inflammation.

Static contraction of the hindlimb muscles, induced by electrical stimulation of the ventral roots, reflexly increases arterial blood pressure and heart rate. Although stimulation of groups III and IV muscle afferents is believed to cause these reflex increases, the responses of these afferents to a level of static contraction that increases arterial pressure have not yet been determined. Therefore, in barbiturate-anesthetized cats, afferent impulses arising from endings in the gastrocnemius muscle were recorded from the L7 or S1 dorsal roots, while the cut peripheral end of the L7 ventral root was stimulated. In addition, the effects of capsaicin (100-200 micrograms) and bradykinin (25 micrograms) on the activity of the groups III and IV afferents stimulated by contraction were examined. Contraction of the gastrocnemius muscle to a level equal to or greater than that needed to cause a pressor response stimulated 12 of 19 (63%) group III afferents and 13 of 19 (68%) group IV afferents. However, the discharge patterns of the group III afferents stimulated by contraction were very different from those of the group IV fibers. No relationship was found between those fibers stimulated by contraction and those stimulated by chemicals. Our results suggest that although both groups III and IV muscle afferents contribute to the reflex cardiovascular increases evoked by static exercise, group III fibers were likely to be stimulated by the mechanical effects of muscular contraction, whereas at least some group IV fibers were likely to be stimulated by the metabolic products of muscular contraction.

Using horseradish peroxidase, we identified the cells of origin of motor fibers in the superior laryngeal and recurrent laryngeal nerves of dogs. Cells giving rise to fibers in the superior laryngeal nerve were found in the dorsal motor nucleus and the nucleus ambiguus, whereas cells giving rise to fibers in the recurrent laryngeal nerve were found in the nucleus ambiguus and nucleus retroambigualis, but usually not in the dorsal motor nucleus.

We have previously shown that contraction of the gracilis muscles of anesthetized dogs reflexly relaxes tracheal smooth muscle. We have also found that electrical stimulation of these afferents decreases total pulmonary resistance (TPR), a calculation that provides a functional index of airway caliber. Despite these findings, we have yet to show that muscular contraction reflexly decreases TPR. Therefore, in 11 alpha-chloralose-anesthetized dogs, we contracted the hindlimb muscles by electrically stimulating the L6-L7 ventral roots while measuring TPR breath by breath. We found that static contraction decreased TPR from 12.6 +/- 1.1 to 10.4 +/- 0.9 cmH2O X l-1 X s (P less than 0.05). This decrease was reflex in origin because it was prevented by section of the spinal roots innervating the working hindlimb. Repetitive twitch contractions (5 Hz) also reflexly decreased TPR, but the effect was smaller than that evoked by static contraction. The reflex decreases in TPR evoked by contraction were unaffected by propranolol but were abolished by atropine. We conclude that muscular contraction dilates the airways by a reflex mechanism whose efferent arm consists of a withdrawal of cholinergic input to airway smooth muscle.

Although neural occlusion has been suggested to occur between the central and reflex mechanisms increasing arterial pressure, evidence consistent with this phenomenon is lacking. To assess the possibility of neural occlusion we recorded, in chloralose-anesthetized cats, the pressor responses to statically contracting the hindlimb muscles and to electrically stimulating histologically confirmed sites in the posterior hypothalamus and subthalamus. We also recorded the pressor responses to topical application of capsaicin onto the intestine and to stimulation of these diencephalic sites. The pressor responses to simultaneous static contraction and diencephalic stimulation were significantly smaller than the algebraic sum of the pressor responses to contraction and diencephalic stimulation evoked separately. Likewise, the pressor responses to simultaneous capsaicin application and diencephalic stimulation were significantly smaller than the algebraic sum of the responses evoked separately. High intensity stimulation of the L7 dorsal root or the diencephalic sites evoked pressor responses similar in magnitude to the algebraic sum of the two responses evoked separately; thus, the inability of the simultaneous maneuvers to evoke pressor responses that summed algebraically was not due to the fact that they caused a maximal effect. Our findings are consistent with the hypothesis that neural occlusion occurs during stimulation of the posterior diencephalon and static muscular contraction.

We previously reported that subarachnoid injection of a peptide antagonist to substance P attenuated by half the reflex pressor response to static muscular contraction. Subsequently, some of the peptide antagonists to substance P have been found to possess local anesthetic effects. Therefore, we have repeated our experiments using a substance P antiserum, which was shown to be without local anesthetic effect. We found that intrathecal injection of the antiserum attenuated by more than half the reflex pressor response to static contraction of the triceps surae muscles of cats.

Although previous investigations have shown that stimulating group III and IV afferents reflexly decreased transverse tension from the trachealis muscle, these measurements provided no functional information about airway caliber. We therefore electrically stimulated gracilis muscle afferents in paralyzed, chloralose anesthetized dogs while recording total pulmonary resistance breath by breath. In addition, we recorded compound action potentials to determine which afferents were stimulated by current intensities of 3, 5, 20, 70 and 200 times motor threshold. We found that stimulating (20 Hz) the nerves at 3 times threshold, a current intensity which activated only group I and II afferents, had no effect on total pulmonary resistance, whereas stimulating teh nerves at 5, 20 and 70 times threshold, current intensities which activated group I, II and III afferents, significantly decreased this variable. Stimulating the nerves at 200 times threshold, a current intensity which activated group IV as well as group I, II and III afferents, decreased total pulmonary resistance significantly more than did stimulating the nerves at 5, 20 or 70 times threshold. In addition stimulating the nerves at 200 times threshold but at frequencies of 2 and 5 Hz significantly decreased total pulmonary resistance. The decrease in total pulmonary resistance evoked by electrically stimulating the nerves at 200 times threshold was unaffected by propranolol but was abolished by atropine methylnitrate. We conclude that stimulating group III and IV gracilis muscle afferents in dogs reflexly decreases total pulmonary resistance, an effect due to the withdrawal of a tonic cholinergic input to the airways.

Although contraction of hindlimb skeletal muscle is well known to reflexly increase ventilation, heart rate and arterial pressure, little is known about the reflex effect of this maneuver on airway smooth muscle tone. Therefore, in chloralose-anesthetized dogs, we recorded transverse tension from the trachealis muscle while we constracted both gracilis muscles by electrically stimulating the gracilis nerves at 5 and 40 Hz. In 11 of the 13 dogs studied, static (40 Hz) contraction decreased tracheal tension, whereas in the remaining 2 dogs, static contraction increased tension. In 9 of 11 dogs, rhythmic (5 Hz) contraction decreased tracheal tension, whereas in the remaining 2, this maneuver increased tension. The changes in tracheal tension induced by stimulating the gracilis nerves were abolished by paralyzing the dogs and were restored, for the most part, after paralysis had dissipated. In addition, the contraction-induced changes in tension were not present when the gracilis muscles were contracted by stimulating the cut peripheral ends of the gracilis nerves. We conclude that muscular contraction reflexly relaxes tracheal smooth muscle in most dogs.

Although static contraction of the hindlimb muscles of anesthetized cats is known to reflexly increase arterial pressure and heart rate, the cardiovascular effects of rhythmic contractions of these muscles is unclear. To help clarify this issue, we determined, in chloralose-anesthetized cats, the effects on arterial pressure and heart rate of rhythmically contracting the hindlimb muscles at a frequency of 5 Hz. In addition, we determined the effect of rhythmic contractions on the impulse activity of group III and IV muscle afferents whose activation is known to increase cardiovascular function. We found that rhythmic contractions increased arterial pressure (from 108 +/- 8 to 134 +/- 9 mmHg; P less than 0.05) and heart rate (from 192 +/- 13 to 208 +/- 10 beats/min; P less than 0.05) in 10 cats and decreased arterial pressure (from 107 +/- 8 to 93 +/- 9 mmHg; P less than 0.05) but did not change heart rate in 9 other cats. The increases were reflex, because they were prevented by cutting the spinal roots innervating the contracting hindlimb. The decreases, however, were not reflex, because they persisted after spinal root section. The differences in the arterial pressure responses to rhythmic contractions may have been partly due to individual differences in the level of anesthesia, because in three cats the pressor responses to this maneuver were converted to depressor responses after giving the cats additional chloralose. Rhythmic contractions of the triceps surae muscles stimulated 8 of 10 group III afferents and 9 of 16 group IV afferents. We conclude that rhythmic contraction is capable of reflexly increasing cardiovascular function in cats provided that the effect is not depressed by anesthesia.

Respiratory responses to chemical activation of thin-fiber afferents from the stomach and the gallbladder were measured in anesthetized cats. Capsaicin or bradykinin applied to the serosal surface of either the stomach or the gallbladder elicited increases in breathing and phrenic nerve activity. Transection of the cervical vagi or the carotid sinus nerves had no effect on these responses. However, the respiratory responses to visceral stimulation were abolished by bilateral transection of the splanchnic nerves. We conclude that activation of thin-fiber afferents from the stomach and gallbladder causes a reflex increase in respiratory output. The initial afferent limb of this reflex is via the splanchnic nerves.

Static muscular contraction reflexly increases arterial blood pressure and heart rate. One possible mechanism evoking this reflex is that potassium accumulates in the interstitial space of a working muscle to stimulate group III and IV afferents whose activation in turn evokes a pressor response. The responses of group III and IV muscle afferents to increases in interstitial potassium concentrations within the range evoked by static contraction are unknown. Thus we injected potassium chloride into the gracilis artery of anesthetized dogs while we measured both gracilis muscle interstitial potassium concentrations with potassium-selective electrodes and the impulse activity of afferents in the gracilis nerve. We found that increasing interstitial potassium concentrations to levels similar to those seen during static contraction stimulated 14 of 16 group III and 29 of 31 group IV afferents. The responses of the afferents to potassium were concentration dependent. The typical response to potassium consisted of a burst of impulses, an effect that returned to control firing rates within 26 s, even though interstitial potassium concentrations remained elevated for several minutes. Although our results suggest that potassium may play a role in initiating the reflex cardiovascular responses to static muscular contraction, the accumulation of this ion does not appear to be solely responsible for maintaining the pressor response for the duration of the contraction.

Cardiac glycosides have been shown to enhance the sensitivity of the reflex cardiovascular responses to stimulation of mechanoreceptors in the heart, carotid sinus and aorta. Little is known, however, about the effect of glycosides on the reflex cardiovascular responses to the contraction-induced stimulation of afferent endings in hindlimb skeletal muscle. We therefore examined the reflex heart rate and arterial pressure responses to static contraction of the hindlimb muscles before and after femoral arterial injection of two doses of acetylstrophanthidin (20 and 80 micrograms/kg). Neither of the two doses enhanced the reflex cardiovascular responses to contraction, although the larger of the two significantly increased femoral venous potassium concentrations from 3.4 +/- 0.2 to 3.8 +/- 0.1 mM. Although injection of the two doses as well as injection of a very large dose of acetylstrophanthidin (400 micrograms/kg) increased baseline mean arterial pressure, these effects were probably caused by the vasoconstrictor action of this agent and not by a chemoreflex, because the increase was not attenuated by denervation of the hindlimb.

Static contraction of the hind limb muscles induced by electrical stimulation of the ventral roots has been firmly established to reflexly increase cardiovascular and ventilatory function. Moreover, Group III and IV afferents are known to compose the afferent arm of this reflex arc. The present experiments investigated the discharge properties of Group III and IV afferents whose activation is responsible for the pressor reflex response to static contraction. In general, we found that Group III afferents were more responsive to mechanical stimuli, such as distortion of their receptive fields and tendon stretch, than were Group IV afferents. In contrast, Group IV afferents were more responsive to ischemic contraction than were Group III afferents. In addition, equal percents of Group III and IV afferents were found to be stimulated by increasing interstitial potassium to levels that were similar to those found during muscular contraction. The afferents' response to potassium adapted within seconds, while the interstitial concentration of this ion remained elevated for several minutes. This rapidly adapting response casts doubt on the effectiveness of potassium as the metabolite that signals blood supply and demand in a working muscle are improperly matched.

Recent studies suggest that, in addition to classical humoral metabolic feedback mechanisms, the mobilization of glucoregulatory hormones and glucose in exercise may be regulated by motor centers in the brain. We, therefore, studied the effect of electrically stimulating the posterior hypothalamic locomotor region (PHLR) for 10 min in decorticated (n = 6) and alpha-chloralose-anesthetized (n = 8) cats. Blood pressure and heart rate were measured, and blood samples were drawn for analysis of hormones and metabolites before, during, and after 10 min of PHLR stimulation. Feedback from contracting muscles was prevented by neuromuscular blockade in decorticated cats and by the anesthesia in anesthetized cats. In decorticated cats, PHLR stimulation elicited increases (2 P less than 0.05) in glucose production (delta 54 +/- 16 mumol.min-1.kg-1), plasma glucose (delta 2.2 +/- 0.7 mmol/l), epinephrine (delta 4.9 +/- 1.8 pmol/l), norepinephrine (delta 2.2 +/- 0.9 pmol/l), glucagon (delta 16 +/- 5 pmol/l), decreases (2 P less than 0.05) in plasma insulin (delta 27 +/- 7 pmol/l), and increases (2 P less than 0.05) in blood pressure (delta 48 +/- 9 mmHg) and heart rate (delta 26 +/- 7 beats/min). In anesthetized cats, PHLR stimulation elicited increases (2 P less than 0.05) in glucose production (delta 12 +/- 4 mumol.min-1.kg-1), plasma glucose (delta 0.4 +/- 0.1 mmol/l), blood pressure (delta 39 +/- 7 mmHg), and heart rate (delta 28 +/- 7 beats/min), whereas changes in catecholamine and insulin concentrations did not reach statistical significance.(ABSTRACT TRUNCATED AT 250 WORDS)

Although group III and IV fibers are known to compose the afferent pathway of the reflex arc causing the pressor response to static muscular contraction, little is known about the neurotransmitters released by these muscle afferents. Somatostatin might be one of these neurotransmitters because this peptide is found in the terminals of fine afferent fibers ending in the dorsal horn of the lumbar spinal cord. Therefore, in chloralose-anesthetized cats, the reflex pressor response to static contraction was examined before and after subarachnoid injections onto the lumbosacral cord of a peptide antagonist to somatostatin. We found that before giving the antagonist, the pressor response to contraction of the triceps surae muscles in 12 cats averaged 33 +/- 4 mm Hg, while 37 +/- 7 minutes after giving the antagonist, the pressor response averaged only 18 +/- 3 mm Hg (p less than 0.001). In contrast, the antagonist to somatostatin had no effect on either the pressor response to electrical stimulation of the cut central end of the sciatic nerve or the pressor response to stimulation of the posterior diencephalon. Furthermore, subarachnoid injection of a peptide antagonist to luteinizing hormone-releasing hormone had no effect on the reflex pressor response to static contraction. Our findings are consistent with the hypothesis that somatostatin plays a role in the spinal transmission of the contraction-induced pressor reflex arising from hind limb skeletal muscle.

Static contraction of hindlimb skeletal muscle is known to increase reflexly arterial pressure and heart rate. Potassium is known to be released by the working muscle and is thought to activate the afferents responsible for the reflex cardiovascular responses to muscular contraction. However, it is not known whether potassium, at interstitial concentrations within the range observed during static contraction, is capable of stimulating these afferents. Thus we injected potassium into the gracilis artery of chloralose-anesthetized dogs while we measured interstitial potassium concentrations in the gracilis muscle with potassium-selective electrodes. In 16 dogs, we found that potassium injections, which increased interstitial potassium concentrations by 4.7 +/- 0.3 mM, increased mean arterial pressure by 18 +/- 3 mmHg and heart rate by 12 +/- 8 beats/min; cutting the obturator nerve abolished these increases. These heart rate and blood pressure responses were of short duration (20 +/- 7 s), even though interstitial potassium remained elevated for a period of several minutes. In 5 of the 16 dogs, static contraction of the gracilis muscle for 60 s increased interstitial potassium concentration by 4.3 +/- 0.3 mM. Our data are consistent with the hypothesis that potassium plays a role in causing the reflex cardiovascular responses to static muscular contraction.

Although both static and rhythmic twitch contractions of the hindlimb muscles of anaesthetised cats have been shown to reflexly evoke pressor responses, the increase in arterial pressure evoked by the former type of contraction has been shown to be substantially larger than that evoked by the latter. We have therefore recorded the impulse activity of single group III and IV muscle afferents, whose activation reflexly increases arterial pressure, while we both statically and rhythmically twitch-contracted the triceps surae muscles of anaesthetised cats. We found that group III afferents (n = 17) discharged significantly more impulses in response to static contraction than in response to rhythmic contraction. By contrast, group IV afferents (n = 18) fired approximately the same number of impulses in response to the two types of contraction. In addition, we found that many of the group III but only a few of the group IV afferents displayed discharge properties suggestive that these afferents were mechanoreceptors. We conclude that the discharge of group III afferents are likely to be responsible for the difference in the magnitudes of the reflex pressor responses evoked by static and rhythmic contraction.

The pressor reflex evoked by muscular contraction (exercise pressor reflex) is one important model of cardiovascular adjustments during static exercise. The central nervous system (CNS) structures mediating this reflex have remained largely obscure. Therefore, we examined the contribution of selected levels of the neuraxis in mediating the pressor reflex evoked by muscular contraction from stimulation of ventral roots. Decerebrate cats exhibited larger pressor reflexes than those found in intact alpha-chloralose-anesthetized cats, a difference more apparent at low (5 Hz or repeated twitch) rather than at high (50 Hz or tetanic) stimulus frequencies. Although a depressor response to 5-Hz stimulation was observed in the intact anesthetized cats, it appeared to be primarily due to anesthetic level, since a depressor response was not observed in decerebrate animals (nonanesthetized). Cerebellectomy produced no changes in the reflexes of the decerebrate animal. Further transection of the neuraxis (caudal to the midcollicular level) attenuated the exercise pressor reflex. The spinal cat demonstrated slight evidence of exercise pressor reflex activity. These results provide clarification as to representation of this pressor reflex within the CNS and establish the reflex's characteristics at several levels of neuraxis integration.

In chloralose-anesthetized cats, we found that D-Pro2-D-Phe7-D-Trp9-substance P (40-100 micrograms), injected intrathecally, reduced the reflex pressor response to static muscular contraction by more than half.

Static muscular contraction has been shown to increase cardiovascular and ventilatory function in reflex manner. The sensory arm of this reflex arc is comprised of group III and IV muscle afferents. The discharge properties of these muscle afferents whose activation causes the pressor reflex response to contraction were investigated. Group III afferents were more responsive to mechanical stimuli, such as tendon stretch and probing their receptive fields than were group IV afferents. In contrast, group III afferents were less responsive to ischemic contraction than were group IV afferents. Equal percentages of group III and IV afferents were stimulated by potassium, lactic acid and arachidonic acid, each of which are metabolic products of contraction. Adenosine, phosphate and lactate, however, had no effect on the discharge of the afferents. Intrathecal injection of antagonists or antibodies to substance P and somatostatin attenuated the pressor response to contraction by about half, a finding that suggests a role for these 2 peptides in the spinal transmission of the reflex.

Static contraction of the hindlimb muscles of cats reflexly increases cardiovascular function, an effect that is potentiated by occlusion of the arterial supply to the working muscles. Although group III and IV afferents are known to be stimulated by and to cause the reflex cardiovascular responses to static muscular contraction, little is known about the responses of these afferents to static contraction when the arterial supply to a working muscle is occluded. We therefore recorded the impulse activity of 24 group III afferents and 30 group IV afferents with endings in the triceps surae while we statically contracted this muscle group, both when the abdominal aorta was occluded and when it was patent. A chi 2 analysis revealed that ischemia increased the responses to static contractions of a significantly higher percentage of group IV afferents than group III afferents (46.7% vs. 12.5%, respectively; P less than 0.02). In addition, two patterns of responses to ischemic contraction were observed. The first pattern was displayed by afferents (n = 10) that were stimulated by nonischemic contraction but were stimulated more by ischemic contraction. The second pattern was displayed by afferents (n = 7) that were not stimulated by nonischemic contraction but were stimulated by ischemic contraction. We conclude that afferents displaying both patterns are likely to contribute to the reflex cardiovascular responses to ischemic contraction.

Using cholinergic and beta-adrenergic antagonists, we characterized the efferent arms of two reflex arcs that relax tracheal smooth muscle in dogs. The reflex arcs investigated were activated by the capsaicin-induced stimulation of afferent endings in the intestine and in the hindlimb. We found that the reflex tracheal relaxations were due to a withdrawal of a tonic cholinergic input. Beta-adrenergic pathways played little role in causing these reflex responses.