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45 results on '"K. Atassi"'

1. Use of tumor markers for differential diagnosis of mesothelioma and secondary pleural malignancies

Author

Bruno Housset, Christos Chouaid, Jean-Paul Tillement, K. Atassi, Isabelle Monnet, Claire Fuhrman, Jean-Claude Duché, I Abd Alsamad, Annesi-Maesano, Isabella, Unité fonctionnelle de pharmacologie-toxicologie, CHI Créteil, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Fuhrman C, Duche JC, C Chouaid, Abd je Alsamad, K Atassi, je Monnet, JP Tillement, B Housset ., Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Mesothelioma, Pathology, Lung Neoplasms, Pleural effusion, MESH: Keratin-19, Tissue Polypeptide Antigen, Clinical Biochemistry, MESH: Antigens, Neoplasm, Gastroenterology, 0302 clinical medicine, Carcinoembryonic antigen, Malignant pleural effusion, Prospective Studies, Carcinoma, Small Cell, Hyaluronic Acid, MESH: Aged, MESH: Middle Aged, medicine.diagnostic_test, biology, MESH: Carcinoma, Small Cell, MESH: Carcinoma, Squamous Cell, General Medicine, Middle Aged, respiratory system, 3. Good health, Area Under Curve, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Keratins, Female, MESH: Pleural Effusion, MESH: Carcinoembryonic Antigen, medicine.medical_specialty, Pleural Neoplasms, Adenocarcinoma, Sensitivity and Specificity, MESH: Pleural Neoplasms, Diagnosis, Differential, 03 medical and health sciences, MESH: Tissue Polypeptide Antigen, MESH: Diagnosis, Differential, Antigens, Neoplasm, Internal medicine, Biomarkers, Tumor, medicine, Thoracoscopy, Humans, Aged, Tumor marker, Keratin-19, MESH: Humans, MESH: Hyaluronic Acid, MESH: Mesothelioma, business.industry, MESH: Adenocarcinoma, MESH: Keratins, MESH: ROC Curve, medicine.disease, MESH: Male, MESH: Prospective Studies, MESH: Sensitivity and Specificity, MESH: Lung Neoplasms, Carcinoembryonic Antigen, respiratory tract diseases, Pleural Effusion, ROC Curve, 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Tumor Markers, Biological, biology.protein, MESH: Area Under Curve, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Differential diagnosis, business, MESH: Female
Abstract

International audience; STUDY OBJECTIVE: The aim of the study was to assess diagnosis value of tumor markers for differential diagnosis between mesothelioma and other pleural tumors. DESIGN AND METHODS: Prospective study of 85 patients attending our hospital with malignant pleural effusion. The diagnostic approach involved routine pleurocentesis followed by pleural needle. When precise diagnosis was not achieved, thoracoscopy with pleural biopsies was performed. Carcinoembryonic antigen (CEA), hyaluronic acid, tissue polypeptide antigen and cyfra 21 to 1 were measured in serum and pleural fluid. RESULTS: By using receiver operating characteristics curves and area under curves, the best diagnostic characteristics were obtained with pleural and serum CEA concentrations. The area under the curve was larger for pleural ACE than for serum ACE. The sensitivity and specificity of a pleural CEA level exceeding 3 ng/mL for ruling out the diagnosis of mesothelioma were 100% and 77%, respectively. CONCLUSION: A CEA level above 3 ng/mL in pleural fluid eliminated the diagnosis of mesothelioma, whereas the other markers were not sufficiently discriminant. However, despite a negative predictive value of 100% at a cutoff of 3 ng/mL, CEA assay in pleural fluid only avoids a small number of diagnostic thoracoscopies.

Published
2000
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2. Pleuropneumonie à Mycobacterium chelonae

Author

Isabelle Monnet, Bruno Housset, L. Bassinet, K. Atassi, L. Jabot, G. Mangiapan, Bernard Maitre, K. Schubel, and Isabelle Honoré

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Bronchiectasis, biology, business.industry, Mycobacterium chelonae, Respiratory infection, Lung abscess, respiratory system, medicine.disease, biology.organism_classification, Empyema, respiratory tract diseases, Surgery, Pneumonia, Pleural disease, Pleurisy, medicine, business
Abstract

Mycobacterium chelonae (M. chelonae) is rarely responsible for respiratory infection. This report concerns the case of an 81-year-old man with previously asymptomatic bronchiectasis, colonised by M. chelonae for 3 years. He was hospitalised for acute dyspnoea and fever due to a right hydro-pneumothorax with cavitated alveolar opacities of the right lung. Pleural fluid and bronchial aspiration were positive for M. chelonae and no other microorganisms were detected. The effusion was drained and the patient treated with clarythromycin and amikacin. The radiological abnormalities improved but the patient's general condition remained poor. Treatment was continued for 11 months. Because of the absence of any other bacteria, clinical deterioration following broad-spectrum antibiotics and stabilisation of the lesions after anti-mycobacterial treatment, our diagnosis was severe M. chelonae pleuro-pneumonia in an immunocompetent patient.

Published
2011
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3. Les bonnes pratiques de la bronchoscopie souple diagnostique, en 2007

Author

Jean-Michel Vergnon, V. Trosini-Desert, K. Atassi, A. Colchen, C. Raspaud, C. Hermant, and M. Febvre

Subjects
Pulmonary and Respiratory Medicine, Gynecology, medicine.medical_specialty, business.industry, Medicine, Professional practice, business, Flexible bronchoscopy
Abstract

Resume Les bonnes pratiques de la bronchoscopie souple diagnostique decrivent les elements importants a connaitre et prendre en compte lors de la realisation d’une bronchoscopie souple diagnostique, programmee, chez l’adulte. Il s’agit d’une mise au point pratique. Les conditions de securite, les complications, l’anesthesie, les risques infectieux, le nettoyage desinfection sont developpes a partir d’une revue de la litterature. La pratique de la bronchoscopie en soins intensifs qui necessite peut etre plus d’attention du fait des terrains plus fragiles fait l’objet d’une discussion etendue. Les performances des differentes techniques de prelevement completent ce travail. Les indications, la bronchoscopie interventionnelle, la bronchoscopie en pediatrie ne sont pas developpees.

Published
2007
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4. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

Author

L. Wang, T. Stys, William E. Boden, R. H. Urbano, D. M. Olinic, Karen S. Pieper, A. Kuijper, E. Soh, J. Nicolau, Jadwiga Nessler, William J. Rogers, Ernesto Rivera, R. Braam, H. Kadr, J. Csikasz, B. Boichev, Prafulla Kerkar, I. Kraiz, R. Babu, Ali Aydinlar, D. Safley, O. Nguyen-Khac, P. Chua, W. Buchanan, C. A. Morales, A. Abyankar, A. Srinivas, S. Genth-Zotz, J. Rocha Faria Neto, D. Drenning, L. Moretti, S. Varma, D. Roth, C. Matei, Jane E. Onken, H. Tumbev, P. Keeling, Xian Li, N. Ciglenecki, Shahyar M. Gharacholou, P. P. Goh, D. Sporn, M. Chang, Marcin Gruchała, R. Foreman, Bogdan Minescu, S. Nawaz, N. Alexeeva, Y. Shalev, C. Fastabend, L. van Zyl, J. F. Certic, J. Longo, J. Wang, K. Dave, Olivier Morel, F. Maatouk, Y. El Rakshy, J. Giacomini, P. Lazov, R. Marino, Dimitar Raev, M. Y. Chan, L. Z. Dextre, Y. Hao, P. Sepulveda, K. Ramshev, C. Bayron, Ameer Kabour, Alon Marmor, Luciano Moreira Baracioli, H. Marais, Rajendra H. Mehta, R. Breedveld, A. Ben Khalfallah, Kurtulus Ozdemir, I. Westendorp, J. A. Quion, Daniel J. George, D. F. Garcia, J.-P Bassand, G. Szalai, Huw Griffiths, O. Ushakov, M. Tzekova, E. Suprun, A. Mowafy, N. El Mansour, Gail V.W. Johnson, Tereshchenko Sn, W. T. Lai, Petr Widimsky, Hany Ragy, V. R. Castillo, M. Padour, Gilles Montalescot, Louie Tirador, Deepak L. Bhatt, M. Marrinan, S. Promisloff, A. Nambiar, Reginald G.E.J. Groutars, S. R. Lee, J. Cabrera, S. Zhang, András Jánosi, K. Wita, R. Sciborski, Annabelle Rodriguez, P. Sedlon, Jaroslaw D. Kasprzak, A. Faynyk, A. Romero Acuña, M. C. Ramirez, Rakesh Gupta, R. Saligrama, Jacek Gniot, Y. Ke, John H. Alexander, X. Liu, E. Baranov, R. Grzywna, Mukul Sharma, A. Linka, Jarosław Wójcik, Haroon Rashid, M. S. Sanchez, M. Gadkari, B. Rao, James S. Zebrack, Paul W. Armstrong, Francois Schiele, Gracita O. Topacio, Peter J. Casterella, A. Belhassane, P. Golino, F. Plat, P. Roberts-Thomson, K. S. Kim, Stephen D. Wiviott, Mathew T. Roe, Y. D. Chen, I. A. Khan, S. Thanvi, S. Isserman, G. Falck, R. M. Coching, S. C. Stamate, M. Ogorek, K. Danisa, Poul Anders Hansen, M. Medvegy, Amos Katz, R. K. Seerangachar, B. Farah, V. Kale, B. Kusnick, Maurice Pye, M. Mosseri, M. Vatutin, D. Weinstein, Norma Keller, A. Mihov, Ewa Mirek-Bryniarska, N. Adjei, S. Sethi, A. Irimpen, M. Broeders, T. Huynh, K. Niezgoda, P. Samardzic, D. Ziperman, Stuart J. Pocock, T. Arad, J. Lewczuk, M. Amuchastegui, R. Moscoso, B. Dimov, W. A. Ahmad, E. Dalli, P. Laothavorn, S. Shaikh, Helmut U. Klein, J. Menon, H. Colombo, L. Fattore, G. Zarrella, Dorairaj Prabhakaran, N. Viboolkitvarakul, Judith D. Goldberg, Neetika Garg, Y. Hasin, F. Rossi Dos Santos, S. J. Vigo, L. Horbach, O. Prokhorov, H. Moellmann, T. R. Vera, C. E. Botta, Domitilla Russo, M. Rossovskaya, David C. Henderson, Rebecca B. Costello, V. Shcherbak, C. J.P.J. Werter, W. Kus, I. Dobre, P. Marechal, T. Nair, H. Nielsen, J. Waites, J. B. Moraes Junior, T. Römer, J. Senior, P. Ionescu, S. Kalashetti, R. N. Ortega, Gail E. Hafley, G. A. Dan, Apur R. Kamdar, Ruth Ann Greenfield, David F. Kong, J. Bergallo, O. Barnum, Antonis S. Manolis, Sumeet Subherwal, S. Schaefer, A. Figueredo, Habib Gamra, S. Bandyopadhyay, V. Miloradovic, Imran Arif, Peter R. Carroll, M. Demirtas, S. Guidera, G. Rogelio, Naseem Jaffrani, N. Mulvihill, Marvin J. Slepian, Darren K. McGuire, Rohit Kalra, Luís A. Providência, F. Van de Werf, Andras Vertes, J. Xu, C. F. Gamio, R. G. Xuereb, R. F. Ramos, E. Kis, N. Bustros, M. De Luca, S. Zhurba, T. Connelly, S. Singhi, F. Gredler, Serdar Kucukoglu, Francesco Fedele, C. Chavez, Christoph Kadel, Antônio Carlos Sobral Sousa, S. Srimahachota, Igor Kaidashev, J. H. Garcia, I. Teodorescu, Birute Petrauskiene, O. Kracoff, Liwa T. Younis, Alain Bouchard, P. Osmancik, Y. Sun, C. Hammett, S. Sabri, William Wallace, Mehmet Yazici, L. Ermoshkina, Harish Chandna, G. Ramos-Lopez, M. Bronisz, Sergio Luiz Zimmermann, Giuseppe Ambrosio, V. Hergeldjieva, César A. Jardim, A. Rifai, H. Lui, A. Lee, J. Scholz Issa, A. Blenkhorn, P. Micale, V. Barbarich, C. Maccallum, Peter J. Grant, G. Topacio, N. Budassi, J. Yan, Keith A.A. Fox, Y. Xia, Jan H. Cornel, A. Rafael, Paul Hermany, S. Potthoff, Mohsin A.F. Khan, Pierre Coste, Neal Ready, N. T. Duda, M. Reyes, A. Chandran, I. G. Gordeev, Anne W. Beaven, B. J.B. Hamer, C. Treasure, Pravin Manga, M. R. Babarskiene, T. Devedzhiev, Alberto Menozzi, L. Lenarz, N. Llerena, Thomas F. Lüscher, Giovânio Vieira da Silva, Y. Malynovsky, L. Ramanathan, M. Belicova, M. O. Ibarra, D. Chew, R. Castillo, M. Kesselbrenner, A. H. Li, E. Baldjiev, M. El-Harari, S. H. Hur, S. Chiaramida, C. E. Chiang, Viliam Fridrich, L. R. Cartasegna, A. Yagensky, Steven E. Hearne, Gregory Pavlides, Witold Rużyłło, Y. Chandrashekhar, S. Welka, H. Petijean, Jose L. Leiva-Pons, Shaul Atar, Andrzej Lubiński, S. Zhao, János Tomcsányi, Narinder Singh, D. Banker, T. Boyek, H. Ebinc, N. Calambur, A. Mouhaffel, M. Creteanu, H. Huang, J. O. Jeong, E. Goudreau, D. Alexopoulos, E. Duronto, S. Car, O. Bashkirtsev, J. Mandak, V. Papademetriou, David O. Williams, Oscar Pereira Dutra, R. Baman, T. J. Hong, J. O. Ibañez, D. L. Gomez, R. K. Jain, R. Jozwa, L. Di Lorenzo, Matthew Wilson, Christian W. Hamm, A. Buakhamsri, Nikitas Moschos, Ashok Kumar, A. Kadiiski, C. Y. Lee, M. Opazo, J. Tang, E. Ferrari, P. Colon-Hernandez, Jean-Pierre Déry, B. Goloborodko, L. Gimple, Diego Ardissino, M. Bergovec, S. Thew, Dariusz Dudek, K. Tang, P. A.G. Zwart, A. Deshpande, S. Sathe, Yves Cottin, V. Pai, O. Koval, J. Lesnik, Pavan S. Reddy, A. Espinoza, Rungroj Krittayaphong, Carisi Anne Polanczyk, E. Kukuy, L. Tejada, J. Nobel, Renato D. Lopes, J. Bagatin, A. Manolova, E. Boudriot, A. Godoy, N. Perepech, Christopher D. Olympios, A. E. Guimarães, James Harris, Aref Rahman, D. Foley, H. J. Kruik, J. Bruguera I Cortada, I. Fotiadis, A. Bharani, Petar Otasevic, Eileen Brown, N. Gratsiansky, J. E. Poulard, Vladimir Gašparović, Habib Haouala, A. de Belder, J. Schmedtje, Lilia Nigro Maia, J. Cobos, Werner Benzer, E. Korban, A. U. Quraishi, X. Hong, A. Bazzi, P. Kotha, L. Gubolino, H. Ingersoll, Debra Marshall, Udo Sechtem, Sandipan Dutta, G. Frago, Anthony Mathur, Shaun G. Goodman, William Bachinsky, A. Hamer, Jaime Gomez, Patrizio Lancellotti, Vance Wilson, L. White, P.P. Mohanan, Aleksandar Knezevic, Sorin J. Brener, Susanna R. Stevens, H. Luquez, S. K. Lee, P. E. Leaes, P. Benjarge, T. Tu, Z. Coufal, N. Koliopoulos, Mahmut Şahin, X. Huang, S. Boldueva, J. De Souza, N. Chidambaram, S. Zolyomi, K. G. Shyu, H. Montecinos, A. Piombo, Wladmir Faustino Saporito, R. L. Kulkarni, I. Szakal, G. Arminio, M. Elbaz, Samir Pancholy, Jang Ho Bae, Giuseppe Musumeci, S. B. Zouari, A. Chois, D. Wojciechowski, A. Bakbak, E. Bozkurt, Kenneth J. Winters, R. Raugaliene, D. Sarkar, J. M. Alegret, Hubertus Heuer, E. Bobescu, E. Roncallo, R. Carlsson, R. Craig McLendon, L K Newby, K. Zrazhevskiy, João Pedro Ferreira, A. Haidar, D. Tellez, Robert Olszewski, Shmuel Gottlieb, H. Jure, A. Garcia Escudero, S. Sengupta, V. Ochean, W. Kostuk, G. Range, F. Leroy, G. Parale, R. Fernandez, M. Fulwani, M. Padovan, Y. Dovgalevskiy, Kreton Mavromatis, H. Hart, Y. G. Ko, F. Seixo, V. Bisne, J. McGarvey, Kimberly L. Blackwell, John H. Strickler, Sanjay Kumar, A. Bordonava, L. Egorova, C. Patocchi, A. Karczmarczyk, Chiara Melloni, Piyamitr Sritara, M. Anastasiou-Nana, Roman Szełemej, K. Penchev, D. Morales, M. Tokmakova, Krzysztof Zmudka, Rakesh Yadav, E. Bressollette, D. Nul, A. L. Astesiano, M. Urban, Abdulhay Albirini, C. T. Chin, F. Moulin, I. M. Coman, R. Watkin, J. Abanilla, J. Brønnum-Schou, J. Anusauskiene, P. Andrade Lotufo, Joseph G. Rogers, M. Bessen, P. C. Sartori, Paulo Roberto Ferreira Rossi, K. Atassi, H. V. Anderson, B. Klugherz, Bateshwar Prasad Singh, Mirza S. Baig, Z. Yusof, J. H. Geertman, A. Labroo, P. Nash, Freek W.A. Verheugt, Nancy J. Brown, M. A. Alcocer, A. Neskovic, L. Francek, Judith S. Hochman, A. Hoffmann, R. Dran, A. Podczeck-Schweighofer, Jeffry Katz, Josh Roberts, Roger E. McLendon, Ronald Rodriguez, T. Downes, A. Roth, L. E. Mayorga, Armagan Altun, José-Luis López-Sendón, M. Krotin, N. van der Merwe, O. Gigliotti, C. Park, G. Brigden, M. Kumbla, D. C G Basart, D. Erdogan, R. van Kranen, J. Beloscar, Johny Joseph, Pierluigi Tricoci, J. Marino, N. Mahon, S. Dani, I. Kovalskyy, Ioannis Nanas, V. Volkov, M. I. Edmilao, J. Kruells-Muench, F. Alamgir, R. Rinaldi, W. E. Mogrovejo, J. Mirat, C. Staniloae, S. Borromeo, H. Kozman, H. Zhang, Y. Zhou, S. Shurmur, A. Manari, M. A. Barrera, A. Vasylenko, D. Keedy, Paul A. Gurbel, Ali Oto, Charles R. Lambert, V. G. Ribeiro, A. Quintero, H. Joshi, L. Tang, J. Allan, C. S. Díaz, F. Carvalho Neuenschwander, Mircea Cintezǎ, M. Kokles, G. Piovaccari, Z. Kovacs, W. Li, C. Beauloye, E. J. Ramos, D. Bertolim Precoma, J. Burstein, G. Covelli, E. C. Zambrano, Assen Goudev, A. Tang, F. Henriquez, S. Tangsuntornwiwat, C. Kirma, GR Aycock, Kenneth W. Mahaffey, M. Ardnt, Jose C. Nicolau, O. Barbarash, E. K. Shin, P. Potapenko, T. Supryadkina, Asok Venkataraman, W. Mogrovejo, M. Acikel, R. Bohorquez, M. Syvänne, M. Chan, H. Mardikar, H. Berlin, O. Quintana, K. Heintz, J. M. Bastos, Guillermo Llamas Esperon, G. Aroney, J. Chen, Nancy H. Collins, C. Ahsan, G. Heins, F. Baer, V. Kondle, Nicholas Danchin, G. Shetty, Sergio Berti, Philip E. Aylward, James Cotton, G. S. Vallejo, Massimo Volpe, Z. Vasiljevic-Pokrajcic, C. Bugueño, Seung Woon Rha, S. Ilic, G. E. Stanciulescu, Z. Li, D. Nassiacos, R. Sciberras, S. Kuanprasert, Denilson Campos de Albuquerque, M. Pavlovic, Craig S. Barr, Mohammed R. Essop, John G. Canto, David T. Roberts, M. Ozdemir, Jacquelyn Miller, T. K. Ong, Sian E. Harding, V. Bose, J. Yoon, R. Syan, M. A. Paz, O. Maskon, Dennis V. Cokkinos, L. Kraus, Z. Masud, K. Amosova, M. Boyarkin, L. Mos, Dmitry Zamoryakhin, Arif Anis Khan, Jeffrey A. Breall, A. Gallino, Ivo Petrov, F. A. Alves da Cost, Saul Vizel, Hugo Vargas Filho, P. Kaewsuwanna, G. Antonelli, Chuen Den Tseng, I. Vakaliuk, J. Miklin, A. El Hawary, Ashok Jacob, D. Gumm, Kurt Huber, G. Pajes, N. Jathappa, Stanislaw Bartus, P. V. Lavhe, C. Romero, J. Balkin, T. Gould, R. Durgaprasad, Felipe Martinez, Henning Ebelt, A. Puri, D. K. Agarwal, E. E. Buyukoner, R. Mora Junior, P. Poliacik, A. Dande, X. Zhao, J. Floro, A. Bagriy, Yuliya Lokhnygina, M. Atieh, V. Batushkin, Valentin Markov, O. Karpenko, Peter Clemmensen, P. Castro, L. Paloscia, F. Florenzano, J. L. Accini, Tony Schibler, J. Arneja, W. Wu, B. Andruszkiewicz, Michael A. Morse, P. Vojtisek, D. Sadler, S. Frischwasser, M. Cayli, W N Leimbach, E. Flores, B. Wang, A Sosa Liprandi, Y. Michalaros, H. C. Finimundi, Raul D. Santos, N. Vijay, E. Magnus Ohman, Y. Karpenko, J. Sirotiakova, Z. Shogenov, D A Zateyshchikov, Eric P. Viergever, R. Bach, Gary S. Niess, D. C. Acosta, G. Piegari, J. B. Gupta, J. Shanes, E. Ronner, J. Arter, Claudio Cavallini, M. A. Hominal, V. Bugan, S. D. Varini, K. Nyman, B. G. Castillo, Sinan Aydoğdu, N. Novikova, D. Wang, P. Simpson, Y. Huang, Taral Patel, Gabriel Tatu-Chitoiu, D. Silva Junior, H. Theron, C. Alvarez, Anikó Ilona Nagy, T. Chua, P. Georgiev, D. Rittoo, G. De Luca, R. Blonder, Alberto Caccavo, D. Koganti, E. Manenti, N. Ghaisas, G. Letcher, D. Platogiannis, Arshed A. Quyyumi, J. Dy, Z. Ples, W. Kunz Sebba Barroso de Souza, Hamid Taheri, S. Kammoun, A. Salvioni, B. Stockins, K. Sutalo, J. C. Post, Merih Kutlu, Vijay K. Chopra, C. Mathis, Stephen M. Schwartz, Manish Jain, D. Coisne, A. Goudev, A. Dalby, João Morais, P. van Kalmthout, Andrzej Budaj, I. Dotani, L. Mircoli, R. Vicari, J. P. Herrman, M. Moran, G. Lupkovics, Alexander Parkhomenko, J. Heath, Andrew Moriarty, C. Pop, J. Y. Hwang, S. Kassam, R. Martingano, I. Nikolskaya, Z. Zheng, Johann S. de Bono, M. Izzo, R. Labonte, E. H. Forte, W. Moleerergpoom, Piera Angelica Merlini, D. Lee, W. Macias, G. Syan, S. Zhou, S. W. Kim, T. Duris, E. Shaoulian, Andreas U. Wali, Marco Antonio Mota Gomes, Pritibha Singh, M. Ovize, M. Del Core, W. Bowden, B. Xu, Ravi Bhagwat, C. Wongvipaporn, J. Vojacek, Steven Lindsay, F. McGrew, J. Gorny, J. D. Pappas, R. Vuyyuru, J. Chahin, Ashraf Reda, T. Lau, E. Conn, J. Meisner, S. Meymandi, A. D. Hrabar, M. Slanina, D. Jarasuniene, C. Lang, A. Vo, Christian Hamm, H. Gogia, Z. Yuan, T. Mathew, A. Van Dorpe, J. Kettner, M. Barbiero, Harvey D. White, L. Rudenko, V. Jain, M. Carter, David Erlinge, G. Ma, V. Sierkova, D. K. Kim, Steven O. Smith, R. K. Premchand, P. Jetty, J. Y. Hou, V. Simanenkov, T. Kaelsch, David P. Foley, A. Francis, Piotr Ponikowski, Ramón Corbalán, D. Connolly, J. Tuma, R. Zambahari, Miodrag Ostojic, R. Lamich, A. Rabelo Alves, V. Tseluyko, G. Moises Azize, L. Khaisheva, G. Pencheva, C. Ingram, J. Cooke, A. Prado, M. De Tollenaere, M. Kim, Alan Rees, Melanie B. Turner, Mark B. Abelson, H. L. Luciardi, L. Illyes, R. Sarma, L. Manriquez, J. A. Marin Neto, D. Iordachescu-Petica, G. Hoedemaker, Victor S. Gurevich, F. Ridocci, J. Grman, F. Waxman, Jorge F. Saucedo, E. Boughzala, B. S. Jagadesa, Heba Abdullah, A. Weiss, N. Bichan, L. Tami, Y. Bouzid, N. I. Gomez, Zafar Sy, Béla Merkely, J. P. Albisu, L. Rodriguez-Ospina, John C. Chambers, L. L. Lobo Marquez, R. Guan, Steven Georgeson, M. K. Sarna, L. Nogueira Liberato de Sousa, Mika Laine, P. Pimentel Filho, Teresa Kawka-Urbanek, G P Arutyunov, S. Elhadad, A. Dambrauskaite, R. Leon de la Fuente, Audes D. M. Feitosa, P. Baetslé, Abraham Al Ahmad, José Francisco Kerr Saraiva, Roland P.T. Troquay, J. Berlingieri, Margaret Arstall, J. L. Coronado, K. Yang, S. V. Shalaev, Bernard J. Gersh, A. El-Etreby, Elżbieta Zinka, F. De Valais, John E.A. Blair, P. Fajardo, M. Rodriguez, R. Boujnah, H. Hammerman, Y. S. Chong, Stigi Joseph, M. H. Jeong, J. Ge, Q. He, Robert S Iwaoka, Bimal R. Shah, J. Sawhney, T. Sakulsaengprapha, G. Werner, Jill Anderson, M. Hondl, Meinrad Gawaz, Gilmar Reis, M. Dalkowski, Tomáš Janota, M. Damiao Gomes Seabra, A. Dharmadhikari, Aleš Linhart, John Elliott, Kodangudi B. Ramanathan, Doron Zahger, Dilek Ural, L. Regos, F. R. Bolohan, Marcello Galvani, B. Zakhary, N. Qureshi, D. Deac, Maria Emília Figueiredo Teixeira, T. Venter, Santosh Gupta, W. Wright, P. Telekes, A. Furber, V. Nykonov, Zhu Junren, M. Cinteza, I. Lang, S. Junejo, D. Martins, Mauro Esteves Hernandes, G. Ishmurzin, Anthony J. Dalby, R. Scioli, P. Babu, R. Habaluyas, V. Mendoza, G. B. Scaro, Matthew T. Roe, M. Senaratne, D. J. van der Heijden, T. Pillay, Yoav Turgeman, J. Moreira, C. Cuccia, C. Astarita, S. De Servi, Robert G. Wilcox, M. C. Constantinescu, Kardiyoloji, Roe Matthew, T., Armstrong Paul, W., Fox Keith, A. A., White Harvey, D., Prabhakaran, Dorairaj, Goodman Shaun, G., Cornel Jan, H., Bhatt Deepak, L., Clemmensen, Peter, Martinez, Felipe, Ardissino, Diego, Nicolau Jose, C., Boden William, E., Gurbel Paul, A., Ruzyllo, Witold, Dalby Anthony, J., McGuire Darren, K., Leiva Pons Jose, L., Parkhomenko, Alexander, Gottlieb, Shmuel, Topacio Gracita, O., Hamm, Christian, Pavlides, Gregory, Goudev Assen, R., Oto, Ali, Tseng Chuen, Den, Merkely, Bela, Gasparovic, Vladimir, Corbalan, Ramon, Cinteza, Mircea, McLendon R., Craig, Winters Kenneth, J., Brown Eileen, B., Lokhnygina, Yuliya, Aylward Philip, E., Huber, Kurt, Hochman Judith, S., Ohman E., Magnu, and Golino, Paolo

Subjects
Male, Prasugrel, Myocardial Infarction, Kaplan-Meier Estimate, Piperazines, Purinergic P2 Receptor Antagonists, Myocardial infarction, education.field_of_study, Cardiovascular diseases [NCEBP 14], Acute Coronary Syndrome, Aged, Angina, Unstable, Aspirin, Cardiovascular Diseases, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Middle Aged, Platelet Aggregation Inhibitors, Prasugrel Hydrochloride, Stroke, Thiophenes, Ticlopidine, Medicine (all), Hazard ratio, Clopidogrel, Acute Coronary Syndromes, General Medicine, Angina, Combination, Cardiology, medicine.drug, medicine.medical_specialty, Acute coronary syndrome, Population, Unstable, Drug Therapy, General & Internal Medicine, Internal medicine, medicine, cardiovascular diseases, education, Acute coronary syndromes, Revascularisation, Unstable angina, business.industry, medicine.disease, REVASCULARIZAÇÃO MIOCÁRDICA, business
Abstract

Item does not contain fulltext BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. RESULTS: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9% of the prasugrel group and 16.0% of the clopidogrel group (hazard ratio in the prasugrel group, 0.91; 95% confidence interval [CI], 0.79 to 1.05; P=0.21). Similar results were observed in the overall population. The prespecified analysis of multiple recurrent ischemic events (all components of the primary end point) suggested a lower risk for prasugrel among patients under the age of 75 years (hazard ratio, 0.85; 95% CI, 0.72 to 1.00; P=0.04). Rates of severe and intracranial bleeding were similar in the two groups in all age groups. There was no significant between-group difference in the frequency of nonhemorrhagic serious adverse events, except for a higher frequency of heart failure in the clopidogrel group. CONCLUSIONS: Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed. (Funded by Eli Lilly and Daiichi Sankyo; TRILOGY ACS ClinicalTrials.gov number, NCT00699998.).

Published
2012
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5. [Pleuropneumonia due to Mycobacterium chelonae]

Author

K, Schubel, L, Bassinet, I, Monnet, L, Jabot, K, Atassi, I, Honoré, B, Maître, B, Housset, and G, Mangiapan

Subjects
Aged, 80 and over, Male, Pleuropneumonia, Mycobacterium Infections, Nontuberculous, Mycobacterium chelonae, Anti-Bacterial Agents, Bronchiectasis, Treatment Outcome, Risk Factors, Clarithromycin, Drainage, Humans, Drug Therapy, Combination, Amikacin
Abstract

Mycobacterium chelonae (M. chelonae) is rarely responsible for respiratory infection. This report concerns the case of an 81-year-old man with previously asymptomatic bronchiectasis, colonised by M. chelonae for 3 years. He was hospitalised for acute dyspnoea and fever due to a right hydro-pneumothorax with cavitated alveolar opacities of the right lung. Pleural fluid and bronchial aspiration were positive for M. chelonae and no other microorganisms were detected. The effusion was drained and the patient treated with clarythromycin and amikacin. The radiological abnormalities improved but the patient's general condition remained poor. Treatment was continued for 11 months. Because of the absence of any other bacteria, clinical deterioration following broad-spectrum antibiotics and stabilisation of the lesions after anti-mycobacterial treatment, our diagnosis was severe M. chelonae pleuro-pneumonia in an immunocompetent patient.

Published
2010

6. [Diagnostic flexible bronchoscopy. Recommendations of the Endoscopy Working Group of the French Society of Pulmonary Medicine]

Author

M, Febvre, V, Trosini-Desert, K, Atassi, C, Hermant, A, Colchen, C, Raspaud, and J M, Vergnon

Subjects
Disinfection, Lung Diseases, Infection Control, Critical Care, Bronchoscopy, Humans, Hemorrhage, France, Respiratory Tract Infections, Platelet Aggregation Inhibitors
Abstract

These guidelines on flexible bronchoscopy depict important clues to be known and taken into account while practicing flexible bronchoscopy, in adult, except in emergency situations. This is a practical clarification. Safety conditions, complications, anesthesia, infectious risks, cleaning and disinfection are detailed from a review of the literature. Intensive care practice of bronchoscopy requires more attention due to higher risks patients and is discussed extensively. Standards and performances of the various sampling techniques complete this work. Indications for bronchoscopy, therapeutic and paediatric bronchoscopy are not covered in these guidelines.

Published
2008

9. 313 Pleuropneumonie grave à Mycobacterium chelonae

Author

Isabelle Monnet, L. Bassinet, Isabelle Honoré, K. Atassi, Bruno Housset, L. Jabot, K. Schubel, and G. Mangiapan

Subjects
Pulmonary and Respiratory Medicine, biology, business.industry, Medicine, Mycobacterium chelonae, business, biology.organism_classification, Microbiology
Published
2007
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11. Complement Activity in Pulmonary Fluid during Sarcoidosis

Author

Jean Bignon, S. Maho, K. Atassi, H. Crémoux, and Claude R. Lambré

Subjects
Adult, Lung Diseases, Male, Sarcoidosis, Pulmonary Fibrosis, Bronchi, Hemolytic Plaque Technique, General Biochemistry, Genetics and Molecular Biology, Complement activity, Leukocyte Count, History and Philosophy of Science, medicine, Humans, Therapeutic Irrigation, Aged, Complement component 5, Chemistry, General Neuroscience, Smoking, Complement System Proteins, Middle Aged, medicine.disease, Complement system, Pulmonary Alveoli, Immunology, Female
Published
1986
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13. [Diagnostic value of fiberoptic bronchoscopy in pneumopathies in immunodeficient adults: a report on 59 examinations (author's transl)]

Author

C, Cordonnier, K, Atassi, P, Ruffie, J P, Vernant, J F, Bernaudin, A, Hirsch, and J, Bignon

Subjects
Adult, Immunosuppression Therapy, Lung Diseases, Bronchoscopy, Fiber Optic Technology, Humans
Abstract

Fifty-nine fiberoptic examinations with endobronchial sampling, brushings, distal bronchial biopsy, and alveolar lavage were conducted during the course of recent pneumopathies in immunodeficient adults with malignant hemopathies (41 cases), solid tumors (7 cases), and other affections (11 cases). Diagnosis was established by fiberoptic bronchoscopy in 4 cases with specific locations of hemopathy or cancer, after bronchial biopsy, in 5 cases of mycoses, after bronchial biopsy, aspiration and/or alveolar lavage, in 4 patients with bacterial pneumonia after bronchial aspiration, and in 1 case of pneumocystosis, after distal biopsy. Diagnosis was not confirmed in the other cases. Mortality (50 p. cent) was similar in the diagnosed group and the group without confirmation of diagnosis. No significant complications due to the examination were observed, except for worsening of the respiratory condition in 7 patients with hypoxemia. The role of fiberoptic bronchoscopy in causing these alterations cannot be excluded. Fiberoptic bronchoscopy appears to be a safe examination except in patients with hypoxemia (PaO2 less than or equal to 50 mmHg). Distal biopsy appeared to be of less value than bronchial biopsy in these patients, as there was a positive correlation between the results of the latter examination and the macroscopic lesions observed in all cases.

Published
1981

14. [Peripheral bronchopulmonary cancers. Diagnostic efficiency of fibroscopic samples. Prospective study on 561 patients]

Author

C, Fabre, P, Leclerc, K, Atassi, R, Bailly, P, Baldeyrou, J, Bordas, J, Bouillard, J, Kernec, M, Lavandier, and J, Lemercier

Subjects
Adult, Aged, 80 and over, Male, Lung Neoplasms, Biopsy, Bronchial Neoplasms, Middle Aged, Bronchoscopy, Catheterization, Peripheral, Fiber Optic Technology, Humans, Female, Prospective Studies, Aged
Abstract

The purpose of this french multicentric study was to evaluate the diagnostic accuracy of samples collected by fibroscopy in peripheral lung cancer with normal endoscopy. Five hundred and sixty-one patients entered the study; a tumour had been diagnosed in 350 of them (62 p. 100). Among these 350 patients, 147 were examined with the help of a light-amplifier screen, and a positive diagnosis was made in 97 (66 p. 100). Guided sample collection in the pathological area (biopsy, brushing, transcatheter aspiration) proved much more rewarding than unguided sample collection (biopsy of the bronchus, simple aspiration or cytology of 3-day sputum): 45 p. 100 positive results versus 18 p. 100 (P less than 0.001). However, sputum cytology still had good diagnostic value since it provided by itself the diagnosis in 14 p. 100 of the cases. Results were significantly inferior in tumours less than 3 cm in diameter.

Published
1988

15. [Efficiency of bronchial and trans-bronchial lung biopsies in 45 cases of sarcoïdosis (author's transl)]

Author

K, Atassi, P, Brochard, C, Demestre, P, Lancret, P, Ruffie, and J, Bignon

Subjects
Adult, Male, Adolescent, Sarcoidosis, Biopsy, Humans, Bronchi, Female, Middle Aged, Lung, Aged
Abstract

Forty five patients with suspected sarcoïdosis underwent bronchial and trans-bronchial lung biopsies in the course of fiberoptic bronchoscopy. Specific histologic lesions were found in 51% of the bronchial biopsies (23/45) and in 67% of trans-bronchial biopsies (30/45). The combination of these two different technics of biopsy has significantly increased the efficacity of fiberoptic bronchoscopy in the diagnosis of sarcoïdosis (87%: 39/45). [P.0,01]. The presence of specific histologic lesions in the trans-bronchial biopsy was independent of the presence or absence of pulmonary parenchyma in the biopsy. The results were classified according to the radiologic stages of the disease. The trans-bronchial lung biopsy, which is described, is well tolerated. Only one complication was observed (partial pneumothorax).

Published
1980

16. Bronchoalveolar lavage fluid and serum complement activity in pulmonary sarcoidosis

Author

C R, Lambré, S, le Maho, G, di Bella, H, de Cremoux, K, Atassi, and J, Bignon

Subjects
Adult, Lung Diseases, Male, Sarcoidosis, Complement C3, Complement System Proteins, Complement C2, Middle Aged, Hemolysis, Body Fluids, Pulmonary Alveoli, Complement C3b, Humans, Female, Therapeutic Irrigation, Immunoelectrophoresis
Abstract

In this work, using bronchoalveolar lavage fluids (BALF), we demonstrated the presence of complement within airways by assaying hemolytic activity of the whole classical pathway (CH50) and by measuring the complement component C2 (C2H50). Patients with sarcoidosis, patients with idiopathic pulmonary fibrosis (IPF), and healthy control subjects were compared. No CH50 activity was found in BALF from healthy control subjects (n = 9), but some activity (mean, 20 CH50) was associated with IPF (n = 7). Complement activities ranged from 40 to 554 CH50 in patients with sarcoidosis (n = 27). During the treatment, complement activity decreased in BALF from the few patients in our series who received corticotherapy. C2 hemolytic activity was detected in BALF from the normal control group (in the absence of CH50 activity). In the sarcoidosis and IPF groups when CH50 was present, the variations in the C2/CH50 ratio were studied. The high ratio observed in BALF from patients with sarcoidosis and a chronic derangement of alveolar structure suggests either an increased C2 production or an alternative complement pathway (C2-independent) activation within their lungs.

Published
1986

17. Right atrial myxoma: an unusual cause of intracardiac right-to-left shunt

Author

J, Rosso, F, Lemaire, H, Geschwind, P, Vouhe, K, Atassi, and B, Teisseire

Subjects
Adult, Heart Neoplasms, Male, Heart Septum, Humans, Heart Atria, Cardiomyopathies, Hypoxia, Myxoma
Abstract

A case of a right-to-left intracardiac shunt caused by a right atrial myxoma is reported. Sudden hypoxaemia was the unique symptom. Measurement of Pao2 while the patient breathed pure oxygen demonstrated the presence of a shunt. Right heart catheterization showed a patent foramen ovale and a pressure gradient between the right atrium and the right ventricle, and between the right and the left atria, explaining the shunt. Cineangiography demonstrated a right atrial myxoma, which was surgically removed. This case report illustrates how a step-by-step diagnostic procedure, based on pathophysiology, may lead to such unexpected findings.

Published
1985

18. Diagnostic yield of bronchoalveolar lavage in pneumonitis occurring after allogeneic bone marrow transplantation

Author

C, Cordonnier, J F, Bernaudin, J, Fleury, M, Feuilhade, C, Haioun, D, Payen, Y, Huet, K, Atassi, and J P, Vernant

Subjects
Adult, Male, Adolescent, Biopsy, Cytomegalovirus, Bronchi, Pneumonia, Middle Aged, Pulmonary Alveoli, Humans, Female, Child, Therapeutic Irrigation, Lung, Bone Marrow Transplantation
Abstract

Fifty-two bronchoalveolar lavages (BAL) were performed in order to investigate 46 episodes of pneumonitis that occurred after allogeneic bone-marrow transplantation. No complications have been attributed to this procedure. A specific etiologic diagnosis was obtained in 24 of 46 episodes (52%) by 26 of 52 BAL (50%). Cytomegalovirus (CMV), diagnosed by the presence of typical inclusions, was the pathogen most frequently identified by BAL (13 of 46 episodes) and was associated with other causes of pneumonia in 4 patients. The other causes of pneumonitis diagnosed by BAL were: giant-cell pneumonia: 1, aspergillosis alone: 3, Pneumocystis carinii: 1, Hemophilus influenzae: 3, isolated pulmonary hemorrhage: 3. One false negative (aspergillosis, n = 1) was diagnosed at autopsy. The overall mortality rate of these episodes was 24%. Thus, BAL appears to be a rapid and reproducible diagnostic method for monitoring pneumonitis in grafted patients, particularly CMV pneumonitis, and may avoid the need for surgical biopsy.

Published
1985

19. Thoracostomy tube pleurodysis by collagen instillation

Author

J. Bignon, F. Lemaire, K. Atassi, A. Pilorget, and P. Menu

Subjects
medicine.medical_specialty, business.industry, Anesthesiology, Pain medicine, General surgery, Thoracostomy tube, medicine, Humans, Pneumothorax, Collagen, Critical Care and Intensive Care Medicine, business, Surgery
Published
1986
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21. [Diagnosis of pleurisy]

Author

B, Maître, K, Atassi, and B, Housset

Subjects
Thoracoscopy, Biopsy, Needle, Bronchoscopy, Humans, Pleura, Emergencies, Pleurisy
Abstract

Diagnosis of pleural effusion, suggested by chest pain or dyspnea, is assessed by physical examination, chest X-ray sometimes completed by other imaging techniques, and mainly by thoracentesis. Thoracentesis is mandatory for the diagnostic of pleural effusion as three diagnosis are associated with an emergency treatment: pulmonary embolism; hemothorax; empyema. If the fluid is a transudate, no further invasive studies are necessary. If the cause of pleural exsudat cannot be established by a careful history, physical examination and fluid analysis, generally closed pleural biopsy should be done, followed, in absence of an established diagnosis, by thoracoscopy. At this time, less than 10% of the cases remain without explanation, leading to a careful follow-up of patients since a carcinomatous lesion may develop in 1/3 of them.

22. [Evaluation of occupational exposures in lung cancer]

Author

Legrand Cattan, K., christos chouaid, Monnet, I., Atassi, K., Bassinet, L., Dhissi, G., Fuhrman, C., Lebargy, F., L Huillier, J. P., Maitre, B., Mangiapan, G., Roos, F., Bignon, J., Housset, B., Pairon, J. C., Annesi-Maesano, Isabella, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), K Cattan Legrand, C Chouaïd, G Dhissi, C Fuhrman, Lebargy F, L'Huillier JP, B Maitre, G Mangiapan, Roos F, J Bignon, B Housset, JC Pairon, Monnet-je, K Atassi, L Bassinet, Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles (ICSN), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
MESH: Aged, Male, MESH: Humans, MESH: Middle Aged, Lung Neoplasms, MESH: Occupational Health, MESH: Workers' Compensation, Middle Aged, MESH: Carcinogens, MESH: Male, MESH: Occupational Exposure, MESH: Lung Neoplasms, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Occupational Exposure, Carcinogens, Humans, Workers' Compensation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, France, MESH: Female, Occupational Health, Aged
Abstract

International audience; Occupational lung cancers are underestimated by the number of cases compensated in the French National Insurance System. Rules of compensation of occupational diseases were recently modified in France. Therefore a study was conducted on incident cases of lung cancer in a general hospital in the Paris area. The aim was to evaluate the exposure to carcinogens using data of a detailed specific occupational questionnaire, and to determine the number of cases who could receive compensation. Two hundred and seven subjects (171 males, 36 females, mean age = 64.5 years) were eligible in 1996, and 122 had an occupational questionnaire. Definite exposure to one or more occupational carcinogens in at least one job was identified in 50 subjects, the most frequent agent was asbestos (42 subjects). Claim for compensation was done in 32 subjects, mainly for asbestos (30 subjects). This study emphasizes the frequency of occupational exposure to carcinogens, and the usefulness of systematic occupational questionnaire in subjects having lung cancer. Social and financial consequences are important for these subjects. Further studies are needed, with recruitement of control subjects to allow calculation of the attributable risk to occupational factors in lung cancer.

Published
2000

23. Strategies to increase colorectal cancer screening.

Author

Atassi K

Subjects
Humans, Physician-Patient Relations, Practice Guidelines as Topic, Reminder Systems, United States, Colorectal Neoplasms diagnosis, Early Detection of Cancer statistics & numerical data, Health Promotion methods
Abstract

Colorectal cancer screening (CRCS) is the only way to detect colorectal cancer in its earlier stages when morbidity and mortality are low. The literature has shown provider-directed recommendations with office system-directed interventions are the best way to increase CRCS rates.

Published
2012
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24. [Pleuropneumonia due to Mycobacterium chelonae].

Author

Schubel K, Bassinet L, Monnet I, Jabot L, Atassi K, Honoré I, Maître B, Housset B, and Mangiapan G

Subjects
Aged, 80 and over, Amikacin therapeutic use, Anti-Bacterial Agents therapeutic use, Bronchiectasis microbiology, Clarithromycin therapeutic use, Drainage, Drug Therapy, Combination, Humans, Male, Mycobacterium Infections, Nontuberculous diagnosis, Mycobacterium Infections, Nontuberculous drug therapy, Mycobacterium Infections, Nontuberculous surgery, Pleuropneumonia diagnosis, Pleuropneumonia drug therapy, Pleuropneumonia surgery, Risk Factors, Treatment Outcome, Mycobacterium Infections, Nontuberculous complications, Mycobacterium chelonae isolation & purification, Pleuropneumonia microbiology
Abstract

Mycobacterium chelonae (M. chelonae) is rarely responsible for respiratory infection. This report concerns the case of an 81-year-old man with previously asymptomatic bronchiectasis, colonised by M. chelonae for 3 years. He was hospitalised for acute dyspnoea and fever due to a right hydro-pneumothorax with cavitated alveolar opacities of the right lung. Pleural fluid and bronchial aspiration were positive for M. chelonae and no other microorganisms were detected. The effusion was drained and the patient treated with clarythromycin and amikacin. The radiological abnormalities improved but the patient's general condition remained poor. Treatment was continued for 11 months. Because of the absence of any other bacteria, clinical deterioration following broad-spectrum antibiotics and stabilisation of the lesions after anti-mycobacterial treatment, our diagnosis was severe M. chelonae pleuro-pneumonia in an immunocompetent patient., (Copyright © 2011 SPLF. Published by Elsevier Masson SAS. All rights reserved.)

Published
2011
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25. Bee sting reaction.

Author

Atassi K

Subjects
Adult, Animals, Emergency Treatment methods, Emergency Treatment nursing, Female, Humans, Nurse's Role, Patient Education as Topic, Anaphylaxis diagnosis, Anaphylaxis etiology, Anaphylaxis therapy, Bees, Emergency Nursing methods, Insect Bites and Stings complications, Nursing Assessment methods
Published
2008
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26. Water intoxication.

Author

Atassi K

Subjects
Adult, Female, Humans, Water administration & dosage, Diet, Reducing adverse effects, Water adverse effects, Water Intoxication diagnosis, Water Intoxication etiology, Water Intoxication therapy
Published
2008
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27. [Diagnostic flexible bronchoscopy. Recommendations of the Endoscopy Working Group of the French Society of Pulmonary Medicine].

Author

Febvre M, Trosini-Desert V, Atassi K, Hermant C, Colchen A, Raspaud C, and Vergnon JM

Subjects
Bronchoscopy methods, Critical Care, Disinfection, France, Hemorrhage etiology, Hemorrhage prevention & control, Humans, Infection Control, Lung Diseases diagnosis, Platelet Aggregation Inhibitors adverse effects, Respiratory Tract Infections prevention & control, Bronchoscopy standards
Abstract

These guidelines on flexible bronchoscopy depict important clues to be known and taken into account while practicing flexible bronchoscopy, in adult, except in emergency situations. This is a practical clarification. Safety conditions, complications, anesthesia, infectious risks, cleaning and disinfection are detailed from a review of the literature. Intensive care practice of bronchoscopy requires more attention due to higher risks patients and is discussed extensively. Standards and performances of the various sampling techniques complete this work. Indications for bronchoscopy, therapeutic and paediatric bronchoscopy are not covered in these guidelines.

Published
2007
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28. Prefixed equimolar nitrous oxide and oxygen mixture reduces discomfort during flexible bronchoscopy in adult patients: a randomized, controlled, double-blind trial.

Author

Atassi K, Mangiapan G, Fuhrman C, Lasry S, Onody P, and Housset B

Subjects
Administration, Inhalation, Bronchoscopy methods, Double-Blind Method, Female, Humans, Male, Middle Aged, Prospective Studies, Bronchoscopy adverse effects, Nitrous Oxide administration & dosage, Oxygen administration & dosage
Abstract

Study Objectives: Flexible bronchoscopy (FB) is an invasive procedure associated with patient discomfort and frequent nose pain. A simple sedation procedure that does not require the intervention of an anesthetist is of interest. The aim of this prospective, randomized, double-blind study was to assess efficiency of nitrous oxide inhalation on the reduction of FB-induced discomfort in adult patients., Design and Settings: Two hundred six patients were randomized to receive either a prefixed equimolar nitrous oxide/oxygen mixture (N2O) or a prefixed equimolar nitrogen and oxygen mixture (control). The primary outcome was stress as assessed by pulse rate and systemic BP during the procedure. Secondary outcomes were self-assessed pain using a visual analog scale (VAS) and patient satisfaction based on a questionnaire. Adverse events were recorded., Results: A significant increase in BP was observed only in the control group (p = 0.003), while pulse rate values did not differ between the two groups. As assessed by the VAS, pain was lower in the N2O group as compared to placebo (p = 0.02). Nose pain and cough were also significantly reduced by N2O. Adverse events, mostly anxiety, were reported in 10 patients., Conclusion: These results indicate that equimolar N2O inhalation is efficient in reducing patient discomfort and may be an alternative to general anesthesia.

Published
2005
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29. [Impact of prior biological assessment of coagulation on the hemorrhagic risk of fiberoptic bronchoscopy].

Author

Zahreddine I, Atassi K, Fuhrman C, Febvre M, Maitre B, and Housset B

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Blood Coagulation Tests, Epistaxis complications, Fiber Optic Technology, Gingival Hemorrhage complications, Heart Failure complications, Humans, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Surveys and Questionnaires, Bronchoscopy adverse effects, Hemorrhage etiology
Abstract

Introduction: The goals of the study were to test the value of coagulation tests to predict bleeding events during fiberoptic bronchoscopy (FOB) and to identify risk factors., Methods: A monocentric prospective study of 426 procedures performed by one physician was realized. A standardized questionnaire and coagulation tests including prothrombine time, activated cephaline time and platelets counts were performed before the procedure. Bleeding events, defined by a loss of more than 50 ml of blood, were recorded for all patients., Results: 44 patients (10.3%) had bleeding events, modifying the procedure in 19 cases. No death occurred following FOB during the study. Among the 17 patients with abnormalities on coagulation test before FOB, only one had significant bleeding. Two risk factors were found as predictors of bleeding events: nose or gum bleeding (OR=4.99, CI (95%) [2.6-9.5]; p<0.001) and left cardiac failure (OR=4.53, CI (95%) [1.7-12.1]; p<0.01)., Conclusion: This study shows that abnormalities on coagulation tests are not predictive for bleeding events. Nose or gum bleeding and left cardiac failure may be risk factors for bleeding events during FOB.

Published
2003

30. Transmission of tuberculosis from adults to children in a Paris suburb.

Author

Madhi F, Fuhrman C, Monnet I, Atassi K, Poirier C, Housset B, and Delacourt C

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Paris epidemiology, Retrospective Studies, Risk Factors, Tuberculin Test, Tuberculosis, Pulmonary diagnosis, Tuberculosis, Pulmonary epidemiology, Infectious Disease Transmission, Vertical, Tuberculosis, Pulmonary transmission
Abstract

Tuberculosis in children is often acquired by contact with a family or household member. The aim of our study was to evaluate risk factors for latent infection and active disease in exposed children in a suburb of Paris. We examined medical records for the period 1997-2000 at six departmental centers for medical prevention in Val de Marne. Thirty-nine patients aged 18 years or more with M. tuberculosis-positive sputum samples, and living with children or adolescents, were identified. Ninety-one children, aged 3 months-17 years, were exposed to these index cases. All the children initially underwent a tuberculin skin test and chest radiography, and children with no criteria for latent infection or active disease at time of initial evaluation were asked to attend a second evaluation 3 months later. Overall, 20 of the 91 (22%) children were infected, including 4 children identified only at the second evaluation. Eight (40%) of the 20 infected children had active disease, including 2 of the 4 children identified at the second evaluation. The risk of infection was not influenced by the children's age, but was significantly associated with three characteristics of the adult cases, i.e., age younger than 40 years, presence of cavitary lesions, and smears with more than 100 bacilli per microscopic field. In conclusion, our results call for early examination of all exposed children, in order to prevent infection and progression to active disease, and for a routine second evaluation after the adult contact has ended., (Copyright 2002 Wiley-Liss, Inc.)

Published
2002
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31. Diagnostic value of medical thoracoscopy in pleural disease: a 6-year retrospective study.

Author

Blanc FX, Atassi K, Bignon J, and Housset B

Subjects
Adenocarcinoma diagnosis, Female, Humans, Male, Mesothelioma diagnosis, Middle Aged, Pleural Diseases diagnosis, Retrospective Studies, Tuberculosis, Pleural diagnosis, Biopsy methods, Pleura pathology, Pleural Neoplasms diagnosis, Thoracoscopy adverse effects, Thoracoscopy methods
Abstract

Study Objectives: Unlike thoracocentesis and closed pleural biopsy (CPB), medical thoracoscopy permits biopsy with direct visualization. In a 6-year retrospective study of patients having undergone at least one medical thoracoscopy, we analyzed the diagnostic yield of thoracoscopy and its value in the management of pleural disease., Setting/patients: From January 1, 1989, to December 31, 1994, 168 medical thoracoscopies were performed on 154 patients (123 men; mean age +/- SE, 61 +/- 1 years), of which 149 were diagnostic and 19 were indicated for therapeutic assessment in malignant mesothelioma (MM). Prior to thoracoscopy, at least one CPB had been performed in 120 of 149 cases, yielding a diagnosis in 96 cases., Results: Thoracoscopy challenged the CPB-based diagnosis in 43 of 96 cases. In 66 cases of nonspecific inflammation diagnosed by CPB, thoracoscopy revealed MM in 16 cases, adenocarcinoma in 10 cases, undetermined carcinoma in 3 cases, and pleural tuberculosis in 3 cases. In 18 cases in which the CPB diagnosis was MM, thoracoscopy, performed for precise staging, challenged the diagnosis in 4 cases. In 12 cases of carcinoma diagnosed by CPB, thoracoscopy specified the histologic type in 7 cases. Thoracoscopic diagnoses were found to be erroneous in 10 of 149 cases, mainly owing to pleural adhesions that limited access to the pleural cavity. There was one thoracoscopy-related death, one case of sepsis, and six cases of empyema., Conclusions: Medical thoracoscopy appears to be efficient and relatively safe in the management of pleural disease. Pleural adhesions can lower its diagnostic value.

Published
2002
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32. [Evaluation of occupational exposures in lung cancer].

Author

Legrand Cattan K, Chouaïd C, Monnet I, Atassi K, Bassinet L, Dhissi G, Fuhrman C, Lebargy F, L'Huillier JP, Maitre B, Mangiapan G, Roos F, Bignon J, Housset B, and Pairon JC

Subjects
Aged, Carcinogens adverse effects, Female, France epidemiology, Humans, Lung Neoplasms epidemiology, Male, Middle Aged, Occupational Health, Workers' Compensation, Lung Neoplasms etiology, Occupational Exposure
Abstract

Occupational lung cancers are underestimated by the number of cases compensated in the French National Insurance System. Rules of compensation of occupational diseases were recently modified in France. Therefore a study was conducted on incident cases of lung cancer in a general hospital in the Paris area. The aim was to evaluate the exposure to carcinogens using data of a detailed specific occupational questionnaire, and to determine the number of cases who could receive compensation. Two hundred and seven subjects (171 males, 36 females, mean age = 64.5 years) were eligible in 1996, and 122 had an occupational questionnaire. Definite exposure to one or more occupational carcinogens in at least one job was identified in 50 subjects, the most frequent agent was asbestos (42 subjects). Claim for compensation was done in 32 subjects, mainly for asbestos (30 subjects). This study emphasizes the frequency of occupational exposure to carcinogens, and the usefulness of systematic occupational questionnaire in subjects having lung cancer. Social and financial consequences are important for these subjects. Further studies are needed, with recruitement of control subjects to allow calculation of the attributable risk to occupational factors in lung cancer.

Published
2000

33. Use of tumor markers for differential diagnosis of mesothelioma and secondary pleural malignancies.

Author

Fuhrman C, Duche JC, Chouaid C, Abd Alsamad I, Atassi K, Monnet I, Tillement JP, and Housset B

Subjects
Adenocarcinoma diagnosis, Adenocarcinoma immunology, Aged, Antigens, Neoplasm blood, Area Under Curve, Carcinoembryonic Antigen blood, Carcinoma, Small Cell diagnosis, Carcinoma, Small Cell immunology, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell immunology, Diagnosis, Differential, Female, Humans, Hyaluronic Acid blood, Hyaluronic Acid metabolism, Keratin-19, Keratins, Lung Neoplasms diagnosis, Lung Neoplasms immunology, Male, Middle Aged, Pleural Effusion immunology, Pleural Neoplasms secondary, Prospective Studies, ROC Curve, Sensitivity and Specificity, Tissue Polypeptide Antigen blood, Biomarkers, Tumor blood, Mesothelioma diagnosis, Pleural Neoplasms diagnosis
Abstract

Study Objective: The aim of the study was to assess diagnosis value of tumor markers for differential diagnosis between mesothelioma and other pleural tumors., Design and Methods: Prospective study of 85 patients attending our hospital with malignant pleural effusion. The diagnostic approach involved routine pleurocentesis followed by pleural needle. When precise diagnosis was not achieved, thoracoscopy with pleural biopsies was performed. Carcinoembryonic antigen (CEA), hyaluronic acid, tissue polypeptide antigen and cyfra 21 to 1 were measured in serum and pleural fluid., Results: By using receiver operating characteristics curves and area under curves, the best diagnostic characteristics were obtained with pleural and serum CEA concentrations. The area under the curve was larger for pleural ACE than for serum ACE. The sensitivity and specificity of a pleural CEA level exceeding 3 ng/mL for ruling out the diagnosis of mesothelioma were 100% and 77%, respectively., Conclusion: A CEA level above 3 ng/mL in pleural fluid eliminated the diagnosis of mesothelioma, whereas the other markers were not sufficiently discriminant. However, despite a negative predictive value of 100% at a cutoff of 3 ng/mL, CEA assay in pleural fluid only avoids a small number of diagnostic thoracoscopies.

Published
2000
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34. [Diagnosis of pleurisy].

Author

Maître B, Atassi K, and Housset B

Subjects
Biopsy, Needle, Bronchoscopy, Emergencies, Humans, Pleura pathology, Pleurisy etiology, Thoracoscopy, Pleurisy diagnosis
Abstract

Diagnosis of pleural effusion, suggested by chest pain or dyspnea, is assessed by physical examination, chest X-ray sometimes completed by other imaging techniques, and mainly by thoracentesis. Thoracentesis is mandatory for the diagnostic of pleural effusion as three diagnosis are associated with an emergency treatment: pulmonary embolism; hemothorax; empyema. If the fluid is a transudate, no further invasive studies are necessary. If the cause of pleural exsudat cannot be established by a careful history, physical examination and fluid analysis, generally closed pleural biopsy should be done, followed, in absence of an established diagnosis, by thoracoscopy. At this time, less than 10% of the cases remain without explanation, leading to a careful follow-up of patients since a carcinomatous lesion may develop in 1/3 of them.

Published
1997

35. Secondary alveolar proteinosis is a reversible cause of respiratory failure in leukemic patients.

Author

Cordonnier C, Fleury-Feith J, Escudier E, Atassi K, and Bernaudin JF

Subjects
Adolescent, Adult, Bone Marrow Transplantation adverse effects, Bronchoalveolar Lavage Fluid cytology, Bronchoalveolar Lavage Fluid microbiology, Causality, Female, Humans, Incidence, Leukemia immunology, Leukemia therapy, Male, Middle Aged, Neutropenia etiology, Periodic Acid-Schiff Reaction, Prognosis, Pulmonary Alveolar Proteinosis epidemiology, Pulmonary Alveolar Proteinosis pathology, Remission, Spontaneous, Respiratory Insufficiency epidemiology, Retrospective Studies, Immunocompromised Host, Leukemia complications, Pulmonary Alveolar Proteinosis etiology, Respiratory Insufficiency etiology
Abstract

We report here our experience of secondary pulmonary alveolar proteinosis (PAP) in patients with hematologic malignancies. The diagnosis of PAP was made by bronchoalveolar lavage (BAL) and based on the identification of periodic acid-Schiff-positive proteinaceous material with the characteristic ultrastructural pattern. Ten patients with leukemia and secondary PAP are described. Three patients had received bone marrow transplants. Data obtained from sequential BAL have shown that at least four of them--all of them achieving complete remission or recovery from neutropenia after bone marrow transplantation--had reversible PAP, and we emphasize this potential reversibility. Furthermore, in order to estimate the frequency of PAP in hematologic patients, we retrospectively studied 113 episodes of pneumonia occurring in our department over a 2-yr period. The incidence of secondary PAP in patients with pulmonary symptoms was so estimated at 5.3% among all the hematologic population, and to 10% in patients with myeloid disorders. This report (1) confirms that BAL is an accurate way to diagnose PAP in immunocompromised hosts, (2) emphasizes that PAP is not an unusual cause of respiratory failure in this population and that it is strongly associated with myeloid disorders, and (3) shows that secondary PAP is potentially reversible, especially if complete remission of the underlying disease is achieved.

Published
1994
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36. [Efficiency of bronchial and trans-bronchial lung biopsies in 45 cases of sarcoïdosis (author's transl)].

Author

Atassi K, Brochard P, Demestre C, Lancret P, Ruffie P, and Bignon J

Subjects
Adolescent, Adult, Aged, Biopsy methods, Female, Humans, Male, Middle Aged, Sarcoidosis pathology, Bronchi pathology, Lung pathology, Sarcoidosis diagnosis
Abstract

Forty five patients with suspected sarcoïdosis underwent bronchial and trans-bronchial lung biopsies in the course of fiberoptic bronchoscopy. Specific histologic lesions were found in 51% of the bronchial biopsies (23/45) and in 67% of trans-bronchial biopsies (30/45). The combination of these two different technics of biopsy has significantly increased the efficacity of fiberoptic bronchoscopy in the diagnosis of sarcoïdosis (87%: 39/45). [P. < 0,01]. The presence of specific histologic lesions in the trans-bronchial biopsy was independent of the presence or absence of pulmonary parenchyma in the biopsy. The results were classified according to the radiologic stages of the disease. The trans-bronchial lung biopsy, which is described, is well tolerated. Only one complication was observed (partial pneumothorax).

Published
1980

38. Relationship between the number of asbestos fibres and the cellular and enzymatic content of bronchoalveolar fluid in asbestos exposed subjects.

Author

Jaurand MC, Gaudichet A, Atassi K, Sébastien P, and Bignon J

Subjects
Adult, Asbestosis pathology, Bronchi cytology, Environmental Exposure, Female, Humans, Macrophages enzymology, Male, Middle Aged, Pulmonary Alveoli cytology, Therapeutic Irrigation, Asbestos analysis, Asbestosis enzymology, Bronchi enzymology, Pulmonary Alveoli enzymology
Published
1980

39. Complement activity in pulmonary fluid during sarcoidosis.

Author

Lambré CR, Le Maho S, de Crémoux H, Atassi K, and Bignon J

Subjects
Adult, Aged, Bronchi immunology, Female, Hemolytic Plaque Technique, Humans, Leukocyte Count, Male, Middle Aged, Pulmonary Alveoli immunology, Pulmonary Fibrosis immunology, Smoking, Therapeutic Irrigation, Complement System Proteins analysis, Lung Diseases immunology, Sarcoidosis immunology
Published
1986
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41. Right atrial myxoma: an unusual cause of intracardiac right-to-left shunt.

Author

Rosso J, Lemaire F, Geschwind H, Vouhe P, Atassi K, and Teisseire B

Subjects
Adult, Cardiomyopathies diagnosis, Cardiomyopathies etiology, Heart Atria, Heart Neoplasms diagnosis, Heart Neoplasms surgery, Humans, Hypoxia etiology, Male, Myxoma diagnosis, Myxoma surgery, Heart Neoplasms physiopathology, Heart Septum, Myxoma physiopathology
Abstract

A case of a right-to-left intracardiac shunt caused by a right atrial myxoma is reported. Sudden hypoxaemia was the unique symptom. Measurement of Pao2 while the patient breathed pure oxygen demonstrated the presence of a shunt. Right heart catheterization showed a patent foramen ovale and a pressure gradient between the right atrium and the right ventricle, and between the right and the left atria, explaining the shunt. Cineangiography demonstrated a right atrial myxoma, which was surgically removed. This case report illustrates how a step-by-step diagnostic procedure, based on pathophysiology, may lead to such unexpected findings.

Published
1985

42. [Diagnostic value of fiberoptic bronchoscopy in pneumopathies in immunodeficient adults: a report on 59 examinations (author's transl)].

Author

Cordonnier C, Atassi K, Ruffie P, Vernant JP, Bernaudin JF, Hirsch A, and Bignon J

Subjects
Adult, Fiber Optic Technology, Humans, Immunosuppression Therapy, Lung Diseases immunology, Bronchoscopy adverse effects, Lung Diseases diagnosis
Abstract

Fifty-nine fiberoptic examinations with endobronchial sampling, brushings, distal bronchial biopsy, and alveolar lavage were conducted during the course of recent pneumopathies in immunodeficient adults with malignant hemopathies (41 cases), solid tumors (7 cases), and other affections (11 cases). Diagnosis was established by fiberoptic bronchoscopy in 4 cases with specific locations of hemopathy or cancer, after bronchial biopsy, in 5 cases of mycoses, after bronchial biopsy, aspiration and/or alveolar lavage, in 4 patients with bacterial pneumonia after bronchial aspiration, and in 1 case of pneumocystosis, after distal biopsy. Diagnosis was not confirmed in the other cases. Mortality (50 p. cent) was similar in the diagnosed group and the group without confirmation of diagnosis. No significant complications due to the examination were observed, except for worsening of the respiratory condition in 7 patients with hypoxemia. The role of fiberoptic bronchoscopy in causing these alterations cannot be excluded. Fiberoptic bronchoscopy appears to be a safe examination except in patients with hypoxemia (PaO2 less than or equal to 50 mmHg). Distal biopsy appeared to be of less value than bronchial biopsy in these patients, as there was a positive correlation between the results of the latter examination and the macroscopic lesions observed in all cases.

Published
1981

43. [Peripheral bronchopulmonary cancers. Diagnostic efficiency of fibroscopic samples. Prospective study on 561 patients].

Author

Fabre C, Leclerc P, Atassi K, Bailly R, Baldeyrou P, Bordas J, Bouillard J, Kernec J, Lavandier M, and Lemercier J

Subjects
Adult, Aged, Aged, 80 and over, Biopsy, Bronchial Neoplasms diagnosis, Bronchial Neoplasms pathology, Bronchoscopy, Catheterization, Peripheral, Female, Fiber Optic Technology, Humans, Lung Neoplasms pathology, Male, Middle Aged, Prospective Studies, Lung Neoplasms diagnosis
Abstract

The purpose of this french multicentric study was to evaluate the diagnostic accuracy of samples collected by fibroscopy in peripheral lung cancer with normal endoscopy. Five hundred and sixty-one patients entered the study; a tumour had been diagnosed in 350 of them (62 p. 100). Among these 350 patients, 147 were examined with the help of a light-amplifier screen, and a positive diagnosis was made in 97 (66 p. 100). Guided sample collection in the pathological area (biopsy, brushing, transcatheter aspiration) proved much more rewarding than unguided sample collection (biopsy of the bronchus, simple aspiration or cytology of 3-day sputum): 45 p. 100 positive results versus 18 p. 100 (P less than 0.001). However, sputum cytology still had good diagnostic value since it provided by itself the diagnosis in 14 p. 100 of the cases. Results were significantly inferior in tumours less than 3 cm in diameter.

Published
1988

44. Bronchoalveolar lavage fluid and serum complement activity in pulmonary sarcoidosis.

Author

Lambré CR, le Maho S, di Bella G, de Cremoux H, Atassi K, and Bignon J

Subjects
Adult, Complement C2 analysis, Complement C3 analysis, Complement C3b analysis, Female, Hemolysis, Humans, Immunoelectrophoresis, Male, Middle Aged, Therapeutic Irrigation, Body Fluids analysis, Complement System Proteins analysis, Lung Diseases metabolism, Pulmonary Alveoli analysis, Sarcoidosis metabolism
Abstract

In this work, using bronchoalveolar lavage fluids (BALF), we demonstrated the presence of complement within airways by assaying hemolytic activity of the whole classical pathway (CH50) and by measuring the complement component C2 (C2H50). Patients with sarcoidosis, patients with idiopathic pulmonary fibrosis (IPF), and healthy control subjects were compared. No CH50 activity was found in BALF from healthy control subjects (n = 9), but some activity (mean, 20 CH50) was associated with IPF (n = 7). Complement activities ranged from 40 to 554 CH50 in patients with sarcoidosis (n = 27). During the treatment, complement activity decreased in BALF from the few patients in our series who received corticotherapy. C2 hemolytic activity was detected in BALF from the normal control group (in the absence of CH50 activity). In the sarcoidosis and IPF groups when CH50 was present, the variations in the C2/CH50 ratio were studied. The high ratio observed in BALF from patients with sarcoidosis and a chronic derangement of alveolar structure suggests either an increased C2 production or an alternative complement pathway (C2-independent) activation within their lungs.

Published
1986
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45. Diagnostic yield of bronchoalveolar lavage in pneumonitis occurring after allogeneic bone marrow transplantation.

Author

Cordonnier C, Bernaudin JF, Fleury J, Feuilhade M, Haioun C, Payen D, Huet Y, Atassi K, and Vernant JP

Subjects
Adolescent, Adult, Biopsy, Child, Cytomegalovirus isolation & purification, Female, Humans, Lung pathology, Male, Middle Aged, Pneumonia etiology, Pulmonary Alveoli microbiology, Therapeutic Irrigation, Bone Marrow Transplantation, Bronchi pathology, Pneumonia diagnosis, Pulmonary Alveoli pathology
Abstract

Fifty-two bronchoalveolar lavages (BAL) were performed in order to investigate 46 episodes of pneumonitis that occurred after allogeneic bone-marrow transplantation. No complications have been attributed to this procedure. A specific etiologic diagnosis was obtained in 24 of 46 episodes (52%) by 26 of 52 BAL (50%). Cytomegalovirus (CMV), diagnosed by the presence of typical inclusions, was the pathogen most frequently identified by BAL (13 of 46 episodes) and was associated with other causes of pneumonia in 4 patients. The other causes of pneumonitis diagnosed by BAL were: giant-cell pneumonia: 1, aspergillosis alone: 3, Pneumocystis carinii: 1, Hemophilus influenzae: 3, isolated pulmonary hemorrhage: 3. One false negative (aspergillosis, n = 1) was diagnosed at autopsy. The overall mortality rate of these episodes was 24%. Thus, BAL appears to be a rapid and reproducible diagnostic method for monitoring pneumonitis in grafted patients, particularly CMV pneumonitis, and may avoid the need for surgical biopsy.

Published
1985
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