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ABSTRACTThis study explores the automobility behavior of millennials (those born between 1980 and 2000) and older adults (65 years and older) and the factors that influence their automobility behavior using cross-sectional data from Hamilton, Ontario. This study focuses specifically on how automobility behavior of millennials and older adults is shaped by their socio-demographic characteristics, living arrangements, attitudes, and preferences toward transportation modes and residential location characteristics. Results from the binomial and ordinal logistic regressions suggest that depending on whether a millennial or older adult lives alone, with a partner, or in an apartment, their automobility behavior differs. The study also finds that positive attitudes and preferences toward sustainable travel behavior make both generations less auto-oriented, especially millennials. Regarding preferred residential location characteristics, compared to older adults, millennials’ preference toward off-street parking in their residential neighborhood is likely to influence their automobile use. Compared to older adults, living arrangements, attitudes, and preferences influence, to a greater extent, millennials’ attributes of automobility. Further, the study also suggests that living arrangements, attitudes, and preferences can differ among millennials and older adults. Consequently, the impact on each of the attributes of automobility behavior will differ.

Using the random forest classification technique, this study explored the role of different factors such as demography, pedestrian and drivers' conditions, collision characteristics, road characteristics, and weather in predicting pedestrian injury severity from automobile-related collisions in Toronto. Spatial information was incorporated in the models to capture spatial autocorrelation. The results revealed the importance of spatial information in predicting pedestrian injury severity. Other important predictors of pedestrian injury severity include aggressive driving, driver's conditions (e.g., inattentive, slowly stopping, driving properly, failing to yield right of way), pedestrian conditions (e.g., normal, inattentive) and dark lighting conditions.

Although co-design is extensively used in education, organizational, and healthcare design, it has rarely been used in public transportation decision-making. Typically, transport service users’ involvement is practiced in the form of public hearings or consultations rather than their direct involvement in the design process. Based on the review of relevant literature on co-design and transportation of immigrants and older adults, this study discusses the promise of co-design for transit service improvement in a developed country context. The study developed a co-design framework to be applied to create a plan for improving transit services for older immigrants in the city of Hamilton, Ontario, Canada. The framework suggests conducting co-design studies by independent investigators instead of service providers to reduce possible biases in the methodology design and decision-making process. Co-design guidelines and principles were developed to address the needs of older immigrants, with the framework addressing their lived experiences, enhancing public engagement, and developing compassionate partnerships among stakeholders. The entire process will allow transit service providers and other community partners to engage with, get insights from, and learn about the impact of their services on older immigrants’ mobility needs. This final output includes a transit service improvement plan, through which the transit service provider can deliver and implement feasible and functional solutions that meet older immigrants’ expectations and improve their transit use experiences.

Abstract Background Physical activity and a healthy diet are important in helping to maintain mobility with aging. This umbrella review aims to identify group-based physical activity and/or nutrition interventions for community-dwelling older adults that improve mobility-related outcomes. Methods Five electronic databases (MEDLINE, Embase, CINAHL, Cochrane CENTRAL, Sociological Abstracts) were searched from inception to December 2021. Eligibility criteria included systematic reviews exploring the effectiveness of physical activity or structured exercise, alone or combined with nutrition interventions on mobility-related outcomes (aerobic capacity, physical function, balance, falls/safety, muscle strength, health-related quality of life/wellbeing). Interventions must have been delivered in a group setting to community-dwelling older adults aged 55+. Two reviewers independently performed eligibility screening, critical appraisal (using AMSTAR 2) and data extraction. The GRADE approach was used to reflect the certainty of evidence based on the size of the effect within each mobility-related outcome category. Older adult/provider research partners informed data synthesis and results presentation. Results In total, 62 systematic reviews (1 high, 21 moderate, 40 low/critically low quality) were identified; 53 included physical activity only, and nine included both physical activity and nutritional supplements. No reviews included nutrition interventions alone. Combined aerobic/resistance, general physical activity, and mind-body exercise all improved physical function and balance (moderate-high certainty). Aerobic/resistance training improved aerobic capacity (high certainty). Resistance training and general physical activity improved muscle strength (moderate certainty). Aerobic/resistance training and general physical activity are likely to reduce falls among older adults (moderate certainty). There was no evidence of benefit for nutritional supplementation with physical activity. Conclusions Group-based physical activity interventions that combine aerobic and resistance, general PA and mind-body exercise can improve measures of mobility in community-dwelling older adults. We found no reviews focused on nutrition only, highlighting a gap in the literature.

Based on in-depth interviews of 17 key informants in Dhaka, Bangladesh, this paper explores the reasons behind the observed modal shift toward motorized two-wheelers that occurred with the COVID-19 pandemic, along with its implications. Analysis of the key informants' perspectives revealed that individuals' inclination towards motorized two-wheelers occurs because of maintaining physical distance, lack of walking and bicycling infrastructure, the high social status associated with motorized two-wheelers, and brand promotion. The implications of this modal shift include increased traffic congestion, GHG emission, and traffic incidents. As interviewees suggest, mass communication, understanding users' perspectives, and promoting equity concepts are needed for a modal shift towards more sustainable options.

Insufficient physical activity (PA) is the fourth prime risk factor for numerous non-communicable diseases. Arab immigrants and refugees (AIR) are at elevated risk for low or no participation in PA due to socio-cultural and ecological factors. This scoping review examined PA prevalence, knowledge, attitudes as well as barriers vs. facilitators to PA engagement across life domains among AIR in Western countries. A systematic search strategy was implemented across five automated databases (PubMed, Embase, Medline, Sociology Database and Transportation Research Board) to locate pertinent English language papers. Seventy-five articles were included in this study, and stakeholder consultation was conducted to validate the findings. The US and Europe are substantially ahead of Canada, Australia, and New Zealand in AIR-PA research. Despite showing positive attitudes and sound knowledge of PA recommendations, AIR exhibited a low PA engagement prevalence, revealing a knowledge-compliance gap. The prevalence of sufficient PA was lowest in the US (11–22%), whereas Europe showed the highest figures (26–45%). Personal barriers to PA participation involved mainstream language illiteracy and limited exercise skills, whereas improved PA literacy was a significant facilitator. Family responsibility and cultural restrictions were common psychosocial/cultural barriers, whereas social support and culturally-sensitive resources were powerful facilitators. Poorly maintained pedestrian/cyclist infrastructure was a leading environmental barrier amongst AIR in North America, but not Europe. Longitudinal and community-engaged AIR-PA research is needed, and intersectoral collaboration is required to inform tailored interventions and inclusive policies, fostering AIR and other vulnerable populations’ exercise participation and improving their health and well-being.

There is a growing awareness of the role played by discrimination in the provision of health care services to immigrants and refugees across Canada. Very little research, however, has explored how perceived discrimination influences patient relationships with health care providers and the health care system in Ontario. This qualitative study documents perceptions of discrimination from a service user perspective in five small and medium-sized Ontario cities. Results of 26 interviews with immigrants and refugees highlight the complex nature and impacts of discrimination in shaping newcomer experiences as a basis for developing effective public policy in health care and social services.

Growing external pressures from human activities and climate change can exacerbate desertification, compromising the livelihoods of more than 25% of the world’s population. The dryland mosaic is defined by land covers that do not behave similarly, and the identification of their recurring or irregular changes over time is crucial, especially in areas susceptible to become desertified. To this aim, the methodological approach of this research is based on the integration of non-linear data analysis techniques, such as recurrence plots (RPs) and recurrence quantification analysis (RQA), applied to the Enhanced Vegetation Index (EVI), which is a functional ecological proxy of above ground net primary production. The research exploits the recurring change detected in vegetation cover over time to gauge the predictable (resilient) behavior of the EVI as well as its chaoticity in a semi-arid Mediterranean region (Apulia, Italy). Interestingly, the results have shown the spatial rendering of recurrence variables, confirming the well-known hot spots of soil degradation and desertification taking place in the region, which are characterized by greater EVI chaoticity, but they have also identified new potential candidate sites. As a result, the susceptibility to land degradation, as measured by the EVI-RQA approach, can help in measuring land desertification with evident operational benefits for landscape planning. The novelty of the research lies in the spatially explicit identification of resilient and less resilient areas to desertification that can support the definition of more targeted interventions and conservation priorities for better planning and sustainable management of Mediterranean drylands.

From 2006 to 2011, Roslin Cells Ltd derived 17 human embryonic stem cells (hESC) while developing (RCM1, RC-2 to -8, -10) and implementing (RC-9, -11 to -17) quality assured standards of operation in a facility operating in compliance with European Union (EU) directives and United Kingdom (UK) licensure for procurement, processing and storage of human cells as source material for clinical application, and targeted to comply with an EU Good Manufacturing Practice specification. Here we describe the evolution and specification of the facility, its operation and outputs, complementing hESC resource details communicated in Stem Cell Research Lab Resources.

The human embryonic stem cell line RCe015-A (RC-11) was derived under quality assured compliance with UK regulation, European Union Directives and International guidance for tissue procurement, processing and storage according to Good Manufacturing Practice (GMP) standards. The cell line was derived from a fragmented cleavage stage embryo voluntarily donated as unsuitable or surplus to fertility requirements following informed consent. RCe015-A (RC-11) shows normal pluripotency marker expression and differentiation to the three germ layers in vitro and in vivo. It has a normal 46XX female karyotype and microsatellite PCR identity, HLA and blood group typing data are available.

The human embryonic stem cell line RCe013-A (RC-9) was derived under quality assured compliance with UK regulation, European Union Directives and International guidance for tissue procurement, processing and storage according to Good Manufacturing Practice (GMP) standards. The cell line was derived from a failed to fertilise oocyte voluntarily donated as unsuitable and surplus to fertility requirements following informed consent. RCe013-A (RC-9) shows normal pluripotency marker expression and differentiation to the three germ layers in vitro and in vivo. It has a normal 46XY male karyotype and microsatellite PCR identity, HLA and blood group typing data are available.

The human embryonic stem cell line RCe007-A (RC-3) was derived from a blastocyst voluntarily donated as unsuitable and surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line shows normal pluripotency marker expression and differentiation to the three germ layers in vitro. It has a normal 46XX female karyotype and HLA and blood group typing data is available.

The human embryonic stem cell line RCe008-A (RC-4) was derived from a blastocyst voluntarily donated as unsuitable and surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line shows normal pluripotency marker expression and differentiation to ectoderm and mesoderm in vitro. It has a mixed 46XX/45X female karyotype and microsatellite PCR identity and blood group typing data is available.

The human embryonic stem cell line RCe009-A (RC-5) was derived from a frozen and thawed Day 2 embryo voluntarily donated as unsuitable and surplus to requirement for fertility treatment following informed consent under licence from the UK Human Fertilisation and Embryology Authority. RCe009-A carries the common DF508 mutation on the cystic fibrosis trans-membrane regulator gene associated with the disease cystic fibrosis. The cell line shows normal pluripotency marker expression and differentiation to the three germ layers in vitro. It has a normal 46XX female karyotype and microsatellite PCR identity, HLA and blood group typing data are available.

The human embryonic stem cell line RCe012-A (RC-8) was derived from a frozen and thawed day 5 embryo cultivated to the blastocyst stage. The embryo was voluntarily donated as unsuitable and surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line shows normal pluripotency marker expression and differentiation to the three germ layers in vitro. It has a normal 46XX female karyotype and microsatellite PCR identity, HLA and blood group typing data is available.

The human embryonic stem cell line RCe006-A (RC-2) was derived from a frozen and thawed blastocyst voluntarily donated as surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line exhibits expression of expected pluripotency markers and in vitro differentiation potential to three germinal lineage representative cell populations. It has a male trisomy 12 karyotype (47XY, +12). Microsatellite DNA marker identity and HLA and blood group typing data are available.

The human embryonic stem cell line RCe014-A (RC-10) was derived from a fresh oocyte voluntarily donated as unsuitable and surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line shows normal pluripotency marker expression and differentiation to the three germ layers in vitro. It has a mixed 46XY and 47XY +12 male karyotype and microsatellite PCR identity, HLA and blood group typing data is available.

The human embryonic stem cell line RCe010-A (RC-6) was derived from a frozen and thawed blastocyst voluntarily donated as unsuitable and surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line shows normal pluripotency marker expression and differentiation to the three germ layers in vitro. It has a normal 46XY male karyotype and microsatellite PCR identity, HLA and blood group typing data are available.

The human embryonic stem cell line RCe011-A (RC-7) was derived from a failed to fertilise oocyte voluntarily donated as unsuitable and surplus to fertility requirements following ethics committee approved informed consent under licence from the UK Human Fertilisation and Embryology Authority. The cell line shows normal pluripotency marker expression and differentiation to the three germ layers in vitro. It has a normal 46XY male karyotype and microsatellite PCR identity, HLA and blood group typing data are available.

The objective of this paper was to identify heterogeneities associated with the relationships between the body mass index (BMI) and individual as well as socio-environmental correlates at the individual- and area-levels. The data sources used were: (i) the 2003 Canadian Community Health Survey; (ii) the 2001 Canadian Census; and (iii) the Enhanced Points of Interest (EPOI) database from the Desktop Mapping Technologies Inc. Participants were adults (≥20 years; n = 12,836; based on a survey weight scheme Nweighted = 5,418,218) from Toronto and Vancouver census metropolitan areas with no missing BMI records. In addition to conventional 1 km-buffers, we constructed activity-space-buffers to better assess the walkability and potentially increased BMI of individuals. Multi-level analysis was then applied to estimate the relative effects of both individual- and area-level risk-factors for increased BMI. The findings demonstrate a negative association between BMI and energy expenditure, mixed land uses, residential density and average value of dwellings, while a positive association was found with low educational attainment. Relationships were independent of individual characteristics such as age and ethnic- ity. Although the majority of the variation in these outcomes was found to be due to individual-level differences, this study did show significant differences at the area-level as well. The activity-space-buffers presented a vast improvement compared to the conventional 1 km-buffers. The results presented support the rationale that targeting high-risk individuals will only address a portion of the increasing BMI problem; it is essential to also address the characteristics of places that compel indi- viduals to make unhealthy choices.

Refugees face considerable challenges upon seeking asylum in Canada, and accessing health care services remains a prominent issue. Recurrent themes in the literature outlining barriers to health-services accessibility include geographic, economic, and cultural barriers. Drawing on the experiences of service providers in Hamilton, Ontario, we explored the efficacy of telemedicine services in bridging the gap between refugee health and health services accessibility. Research methodology included structured interviews with clinicians who provide health-care services to refugees, complemented by a scoping literature review. The results of this exploratory study demonstrate the efficacy of telemedicine in encouraging dialogue and policy change in the greater health-care setting, and its potential to increase access to specialist health-care services.

Because human land uses tend to expand over time, forests that share a high proportion of their borders with anthropogenic uses are at higher risk of further degradation than forests that share a high proportion of their borders with non-forest, natural land cover (e.g., wetland). Using 1-km advanced very high resolution radiometer (AVHRR) satellite-based land cover, we present a method to separate forest fragmentation into natural and anthropogenic components, and report results for all inhabited continents summarized by World Wildlife Fund biomes. Globally, over half of the temperate broadleaf and mixed forest biome and nearly one quarter of the tropical rainforest biome have been fragmented or removed by humans, as opposed to only 4% of the boreal forest. Overall, Europe had the most human-caused fragmentation and South America the least. This method may allow for improved risk assessments and better targeting for protection and remediation by identifying areas with high amounts of human-caused fragmentation.

We report an analysis of forest fragmentation based on 1-km resolution land-cover maps for the globe. Measurements in analysis windows from 81 km 2 (9 x 9 pixels, "small" scale) to 59,049 km 2 (243 x 243 pixels, "large" scale) were used to characterize the fragmentation around each forested pixel. We identified six categories of fragmentation (interior, perforated, edge, transitional, patch, and undetermined) from the amount of forest and its occurrence as adjacent forest pixels. Interior forest exists only at relatively small scales; at larger scales, forests are dominated by edge and patch conditions. At the smallest scale, there were significant differences in fragmentation among continents; within continents, there were significant differences among individual forest types. Tropical rain forest fragmentation was most severe in North America and least severe in Europe-Asia. Forest types with a high percentage of perforated conditions were mainly in North America (five types) and Europe-Asia (four types), in both temperate and subtropical regions. Transitional and patch conditions were most common in 11 forest types, of which only a few would be considered as "naturally patchy" (e.g., dry woodland). The five forest types with the highest percentage of interior conditions were in North America; in decreasing order, they were cool rain forest, coniferous, conifer boreal, cool mixed, and cool broadleaf.