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1. Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response

Author: Hongming Ma, Wei Qian, Monika Bambouskova, Patrick L. Collins, Sofia I. Porter, Andrea K. Byrum, Rong Zhang, Maxim Artyomov, Eugene M. Oltz, Nima Mosammaparast, Jonathan J. Miner, and Michael S. Diamond
Subjects: interferon-stimulated gene, regulation, innate immunity, CRISPR, DNA virus, RNA virus, Microbiology, QR1-502
Abstract: ABSTRACT Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a genome-wide CRISPR-Cas9 screening approach to identify host factors that modulate interferon-stimulated gene (ISG) expression, we identified the DNA binding protein Barrier-to-autointegration factor 1 (Banf1), a previously described inhibitor of retrovirus integration, as a modulator of basal cell-intrinsic immunity. Ablation of Banf1 by gene editing resulted in chromatin activation near host defense genes with associated increased expression of ISGs, including Oas2, Rsad2 (viperin), Ifit1, and ISG15. The phenotype in Banf1-deficient cells occurred through a cGAS-, STING-, and IRF3-dependent signaling axis, was associated with reduced infection of RNA and DNA viruses, and was reversed in Banf1 complemented cells. Confocal microscopy and biochemical studies revealed that a loss of Banf1 expression resulted in higher level of cytosolic double-stranded DNA at baseline. Our study identifies an undescribed role for Banf1 in regulating the levels of cytoplasmic DNA and cGAS-dependent ISG homeostasis and suggests possible therapeutic directions for promoting or inhibiting cell-intrinsic innate immune responses. IMPORTANCE Although the interferon (IFN) signaling pathway is a key host mechanism to restrict infection of a diverse range of viral pathogens, its unrestrained activity either at baseline or in the context of an immune response can result in host cell damage and injury. Here, we used a genome-wide CRISPR-Cas9 screen and identified the DNA binding protein Barrier-to-autointegration factor 1 (Banf1) as a modulator of basal cell-intrinsic immunity. A loss of Banf1 expression resulted in higher level of cytosolic double-stranded DNA at baseline, which triggered IFN-stimulated gene expression via a cGAS-STING-IRF3 axis that did not require type I IFN or STAT1 signaling. Our experiments define a regulatory network in which Banf1 limits basal inflammation by preventing self DNA accumulation in the cytosol.
Published: 2020
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2. Rapid profiling of DNA replication dynamics using mass spectrometry–based analysis of nascent DNA

Author: Mohamed E. Ashour, Andrea K. Byrum, Alice Meroni, Jun Xia, Saurabh Singh, Roberto Galletto, Susan M. Rosenberg, Alessandro Vindigni, and Nima Mosammaparast
Subjects: Cell Biology
Abstract: The primary method for probing DNA replication dynamics is DNA fiber analysis, which utilizes thymidine analog incorporation into nascent DNA, followed by immunofluorescent microscopy of DNA fibers. Besides being time-consuming and prone to experimenter bias, it is not suitable for studying DNA replication dynamics in mitochondria or bacteria, nor is it adaptable for higher-throughput analysis. Here, we present mass spectrometry–based analysis of nascent DNA (MS-BAND) as a rapid, unbiased, quantitative alternative to DNA fiber analysis. In this method, incorporation of thymidine analogs is quantified from DNA using triple quadrupole tandem mass spectrometry. MS-BAND accurately detects DNA replication alterations in both the nucleus and mitochondria of human cells, as well as bacteria. The high-throughput capability of MS-BAND captured replication alterations in an E. coli DNA damage-inducing gene library. Therefore, MS-BAND may serve as an alternative to the DNA fiber technique, with potential for high-throughput analysis of replication dynamics in diverse model systems.
Published: 2023
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3. The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

Author: Diana Y. Lu, Jana M. Ellegast, Kenneth N. Ross, Clare F. Malone, Shan Lin, Nathaniel W. Mabe, Neekesh V. Dharia, Ashleigh Meyer, Amy Conway, Angela H. Su, Julia Selich-Anderson, Cenny Taslim, Andrea K. Byrum, Bo Kyung A. Seong, Biniam Adane, Nathanael S. Gray, Miguel N. Rivera, Stephen L. Lessnick, and Kimberly Stegmaier
Subjects: Cell Biology
Abstract: Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which provides a context to precisely study the transcriptional circuits that support mutant TF-driven oncogenesis. A broadly relevant mechanism that has garnered intense focus involves the ability of mutant TFs to hijack wild-type lineage-specific TFs in self-reinforcing transcriptional circuits. However, it is not known whether this specific type of circuitry is equally crucial in all mutant TF-driven cancers. Here we describe an alternative yet central transcriptional mechanism that promotes Ewing sarcoma, wherein constraint, rather than reinforcement, of the activity of the fusion TF EWS–FLI supports cancer growth. We discover that ETV6 is a crucial TF dependency that is specific to this disease because it, counter-intuitively, represses the transcriptional output of EWS–FLI. This work discovers a previously undescribed transcriptional mechanism that promotes cancer.
Published: 2023
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4. Cherenkov Telescope Array : the World’s largest VHE gamma-ray observatory

Author: Roberta Zanin, H. Abdalla, H. Abe, S. Abe, A. Abusleme, F. Acero, A. Acharyya, V. Acin Portella, K. Ackley, R. Adam, C. Adams, S.S. Adhikari, I. Aguado Ruesga, I. Agudo, R. Aguilera, A. Aguirre Santaella, F. Aharonian, A. Alberdi, R. Alfaro, J. Alfaro, C. Alispach, R. Aloisio, R. Alves Batista, J.P. Amans, L. Amati, E. Amato, L. Ambrogi, G. Ambrosi, M. Ambrosio, R. Ammendola, J. Anderson, M. Anduze, E.O. Anguner, L.A. Antonelli, V. Antonuccio, P. Antoranz, R. Anutarawiramkul, J. Aragunde Gutierrez, C. Aramo, A. Araudo, M. Araya, A. Arbet Engels, C. Arcaro, V. Arendt, C. Armand, T. Armstrong, F. Arqueros, L. Arrabito, B. Arsioli, M. Artero, K. Asano, Y. Ascasibar, J. Aschersleben, M. Ashley, P. Attina, P. Aubert, C. B. Singh, D. Baack, A. Babic, M. Backes, V. Baena, S. Bajtlik, A. Baktash, C. Balazs, M. Balbo, O. Ballester, J. Ballet, B. Balmaverde, A. Bamba, R. Bandiera, A. Baquero Larriva, P. Barai, C. Barbier, V. Barbosa Martins, M. Barcelo, M. Barkov, M. Barnard, L. Baroncelli, U. Barres de Almeida, J.A. Barrio, D. Bastieri, P.I. Batista, I. Batkovic, C. Bauer, R. Bautista González, J. Baxter, U. Becciani, J. Becerra González, Y. Becherini, G. Beck, J. Becker Tjus, W. Bednarek, A. Belfiore, L. Bellizzi, R. Belmont, W. Benbow, D. Berge, E. Bernardini, M.I. Bernardos, K. Bernlöhr, A. Berti, M. Berton, B. Bertucci, V. Beshley, N. Bhatt, S. Bhattacharyya, W. Bhattacharyya, B. Y. Bi, G. Bicknell, N. Biederbeck, C. Bigongiari, A. Biland, R. Bird, E. Bissaldi, J. Biteau, M. Bitossi, O. Blanch, M. Blank, J. Blazek, J. Bobin, C. Boccato, F. Bocchino, C. Boehm, M. Bohacova, C. Boisson, J. Boix, J.P. Bolle, J. Bolmont, G. Bonanno, C. Bonavolontà, L. Bonneau Arbeletche, G. Bonnoli, P. Bordas, J. Borkowski, R. Bose, D. Bose, Z. Bosnjak, E. Bottacini, Markus Böttcher, M.T. Botticella, C. Boutonnet, F. Bouyjou, V. Bozhilov, E. Bozzo, L. Brahimi, C. Braiding, S. Brau Nogue, S. Breen, J. Bregeon, M. Breuhaus, A. Brill, W. Brisken, E. Brocato, A.M. Brown, K. Brügge, P. Brun, F. Brun, L. Brunetti, G. Brunetti, P. Bruno, A. Bruno, A. Bruzzese, N. Bucciantini, J. H. Buckley, R. Bühler, A. Bulgarelli, T. Bulik, M. Bünning, M. Bunse, M. Burton, A. Burtovoi, M. Buscemi, S. Buschjager, G. Busetto, J. Buss, K. Byrum, A. Caccianiga, F. Cadoux, A. Calanducci, C. Calderon, J. Calvo Tovar, R. A. Cameron, P. Campana, R. Canestrari, F. Cangemi, B. Cantlay, M. Capalbi, M. Capasso, M. Cappi, A. Caproni, R. Capuzzo Dolcetta, P. Caraveo, V. Cárdenas, L. Cardiel, M. Cardillo, C. Carlile, S. Caroff, R. Carosi, A. Carosi, E. Carquin, M. Carrere, J.M. Casandjian, S. Casanova, F. Cassol, F. Catalani, O. Catalano, D. Cauz, A. Ceccanti, C. Celestino Silva, K. Cerny, M. Cerruti, E. Chabanne, P. Chadwick, Y. Chai, P. Chambery, C. Champion, S. Chaty, A. Chen, K. Cheng, M. Chernyakova, G. Chiaro, A. Chiavassa, M. Chikawa, V.R. Chitnis, J. Chudoba, L. Chytka, S. Cikota, A. Circiello, P. Clark, M. Colak, E. Colombo, S. Colonges, A. Comastri, A. Compagnino, V. Conforti, E. Congiu, R. Coniglione, J. Conrad, F. Conte, J.L. Contreras, P. Coppi, R. Cornat, J. Coronado Blazquez, J. Cortina, A. Costa, H. Costantini, G. Cotter, B. Courty, S. Covino, S. Crestan, P. Cristofari, R. Crocker, J. Croston, K. Cubuk, O. Cuevas, X. Cui, G. Cusumano, S. Cutini, G. D'Amico, F. D'Ammando, P. D'Avanzo, P. Da Vela, M. Dadina, S. Dai, M. Dalchenko, M. Dall'Ora, M.K. Daniel, J. Dauguet, I. Davids, J. Davies, B. Dawson, A. De Angelis, A.E. de Araujo Carvalho, M. de Bony de Lavergne, G. De Cesare, F. de Frondat, I. de la Calle, E. de Gouveia Dal Pino, B. De Lotto, A. De Luca, D. De Martino, M. de Naurois, E. de Ona Wilhelmi, F. De Palma Persio, N. De Simone, V. de Souza Valle, E. Delagnes, G. Deleglise Reznicek, C. Delgado, A.G. Delgado Giler, J. Delgado Mengual Valle, Domenico Della Volpe, D. Depaoli, J. Devin, T. Di Girolamo, C. Di Giulio Pierro, L. Di Venere, C. Díaz, C. Dib, S. Diebold, S. Digel, A. Djannati Atai, J. Djuvsland, A. Dmytriiev, K. Docher, A. Domínguez, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, Rita Cassia dos Anjos, J.L. Dournaux, T. Downes, G. Drake, H. Drass, D. Dravins, C. Duangchan, A. Duara, G. Dubus, L. Ducci, C. Duffy, D. Dumora, K. Dundas Mora, A. Durkalec, V.V. Dwarkadas, J. Ebr, C. Eckner, J. Eder, E. Edy, K. Egberts, S. Einecke, C. Eleftheriadis, D. Elsässer, G. Emery, D. Emmanoulopoulos, J.P. Ernenwein, M. Errando, P. Escarate, J. Escudero, C. Espinoza, S. Ettori, A. Eungwanichayapant, P. Evans, C. Evoli, M. Fairbairn, D. Falceta Goncalves, A. Falcone, V. Fallah Ramazanı, R. Falomo, K. Farakos, G. Fasola, A. Fattorini, Y. Favre, R. Fedora, E. Fedorova, K. Feijen, Q. Feng, G. Ferrand, G. Ferrara, O. Ferreira, M. Fesquet, E. Fiandrini, A. Fiasson, M. Filipovic, D. Fink, J.P. Finley, V. Fioretti, D.F.G. Fiorillo, M. Fiorini, S. Flis, H. Flores, L. Foffano, C. Fohr, M.V. Fonseca, L. Font, G. Fontaine, O. Fornieri, P. Fortin, L. Fortson, N. Fouque, B. Fraga, A. Franceschini, F.J. Franco, L. Freixas Coromina, L. Fresnillo, D. Fugazza, Y. Fujita, S. Fukami, Y. Fukazawa, D. Fulla, S. Funk, A. Furniss, S. Gabici, D. Gaggero, G. Galanti, P. Galdemard, Y. A. Gallant, D. Galloway, S. Gallozzi, V. Gammaldi, R. Garcia, L. E. García-Muñoz, E. Garcia Lopez, F. Gargano, C. Gargano, S. Garozzo, D. Gascon, T. Gasparetto, D. Gasparrini, H. Gasparyan, M. Gaug, N. Geffroy, A. Gent, S. Germani, A. Ghalumyan, A. Ghedina, G. Ghirlanda, F. Gianotti, S. Giarrusso, M. Giarrusso, G. Giavitto, B. Giebels, N. Giglietto, V. Gika, F. Gillardo, R. Gimenes, F. Giordano, E. Giro, M. Giroletti, Andrea Giuliani, M. Gjaja, J.F. Glicenstein, P. Gliwny, H. Goksu, P. Goldoni, J.L. Gomez, M.M. Gonzalez, Juan Manuel Gonzalez, K.S. Gothe, D. Gotz Coelho, T. Grabarczyk, R. Graciani, P. Grandi, G. Grasseau, D. Grasso, D. Green, J. Green, T. Greenshaw, P. Grespan, A. Grillo, M.H. Grondin, J. Grube, V. Guarino, B. Guest, O. Gueta, M. Günduz, S. Gunji, G. Gyuk, J. Hackfeld, D. Hadasch, L. Hagge, A. Hahn, J.E. Hajlaoui, A. Halim, P. Hamal, W. Hanlon, Y. Harada, M.J. Hardcastle, M. Harvey Collado, T. Haubold, A. Haupt, M. Havelka, K. Hayashi, M. Hayashida, H. He, L. Heckmann, M. Heller, F. Henault, Gilles Henri, G. Hermann, S. Hernández Cadena, J. Herrera Llorente, O. Hervet, J. Hinton, A. Hiramatsu, K. Hirotani, B. Hnatyk, R. Hnatyk, J.K. Hoang, D. H.H. Hoffmann, C. Hoischen, J. Holder, M. Holler, B. Hona, D. Horan, Dieter Horns, P. Horvath, J. Houles, M. Hrabovsky, D. Hrupec, Y. Huang, J.‑M. Huet, G. Hughes, G. Hull, T.B. Humensky, M. Hütten, M. Iarlori, J.M. Illa, R. Imazawa, T. Inada, F. Incardona, A. Ingallinera, S. Inoue, T. Inoue, Y. Inoue, F. Iocco, K. Ioka, M. Ionica, S. Iovenitti, A. Iriarte, K. Ishio, W. Ishizaki, Y. Iwamura, J. Jacquemier, M. Jacquemont, M. Jamrozy, P. Janecek, F. Jankowsky, A. JardinBlicq, C. Jarnot, P. Jean Martínez, L. Jocou, N. Jordana, M. Josselin, I. JungRichardt, F.J.P.A. Junqueira, C. Juramy Gilles, P. Kaaret, L.H.S. Kadowaki, M. Kagaya, R. Kankanyan, D. Kantzas, V. Karas, A. Karastergiou, S. Karkar, J. Kasperek, H. Katagiri, J. Kataoka, K. Katarzynski, S. Katsuda, N. Kawanaka, D. Kazanas, D. Kerszberg, B. Khélifi, M.C. Kherlakian, T.P. Kian, D.B. Kieda, T. Kihm, S. Kim, S. Kisaka, R. Kissmann, R. Kleijwegt, G. Kluge, W. Kluźniak, J. Knapp, A. Kobakhidze, Y. Kobayashi, B. Koch, J. Kocot, K. Kohri, N. Komin, A. Kong, K. Kosack, F. Krack, M. Krause, F. Krennrich, H. Kubo, V. N. Kudryavtsev, S. Kunwar, J. Kushida, P. Kushwaha, Barbera Parola, G. La Rosa, R. Lahmann, A. Lamastra, M. Landoni, D. Landriu, R.G. Lang, J. Lapington, P. Laporte, P. Lason, J. Lasuik, J. Lazendic Galloway, T. Le Flour, P. Le Sidaner, S. Leach, S.H. Lee, W.H. Lee, S. Lee Oliveira, A. Lemiere, M. Lemoine Goumard, J.P. Lenain, F. Leone, V. Leray, G. Leto, F. Leuschner, R. Lindemann, E. Lindfors, L. Linhoff, I. Liodakis, A. Lipniacka, M. Lobo, Thomas Lohse, S. Lombardi, A. Lopez, M. Lopez, R. Lopez Coto, F. Louis, M. Louys, F. Lucarelli, H. Ludwig Boudi, P.L. Luque Escamilla, M.C. Maccarone, E. Mach, A.J. Maciejewski, J. Mackey, P. Maeght, C. Maggio, G. Maier, P. Majumdar, M. Makariev, M. Mallamaci, R. Malta Nunes de Almeida, D. Malyshev, D. Mandat, G. Maneva, M. Manganaro, P. Manigot, K. Mannheim, N. Maragos, D. Marano, M. Marconi, A. Marcowith, M. Marculewicz, B. Marcun, J. Marin, N. Marinello, P. Marinos, S. Markoff, P. Marquez, G. Marsella, J. M. Martin, P. G. Martin, M. Martinez, G. Martinez, O. Martinez, H. Martinez Huerta, C. Marty, R. Marx, N. Masetti, P. Massimino, H. Matsumoto, N. Matthews, G. Maurin, W. Max Moerbeck, N. Maxted, M.N. Mazziotta, S.M. Mazzola, J.D. Mbarubucyeye, L. Mc Comb, I. McHardy, S. McKeague, S. McMuldroch, E. Medina, D. Medina Miranda, A. Melandri, C. Melioli, D. Melkumyan, S. Menchiari, S. Mereghetti, G. Merino Arevalo, E. Mestre, J.L. Meunier, T. Meures, S. Micanovic, M. Miceli, M. Michailidis, J. Michalowski, T. Miener, I. Mievre, J. D. Miller, T. Mineo, M. Minev, J.M. Miranda, A. Mitchell, T. Mizuno, B. A. Mode, R. Moderski, L. Mohrmann, E. Molinari, T. Montaruli, I. Monteiro, C. Moore, A. Moralejo, D. Morcuende Parrilla, E. Moretti, K. Mori, P. Moriarty, K. Morik, P. Morris, A. Morselli, K. Mosshammer, R. Mukherjee, J. Muller, C. Mundell, J. Mundet, T. Murach, A. Muraczewski, H. Muraishi, I. Musella, A. Musumarra, A. Nagai, S. Nagataki, T. Naito, T. Nakamori, K. Nakashima, K. Nakayama, N. Nakhjiri, G. Naletto, D. Naumann, L. Nava, M.A. Nawaz, H. Ndiyavala, D. Neise, L. Nellen, R. Nemmen, N. Neyroud, K. Ngernphat, T. Nguyen Trung, L. Nicastro, L. Nickel, J. Niemiec, D. Nieto, C. Nigro, M. Nikołajuk, D. Ninci, K. Noda, Y. Nogami, S. Nolan, R. P. Norris, D. Nosek, M. Nöthe, V. Novotny, S. Nozaki, F. Nunio, P. O'Brien, K. Obara, Y. Ohira, M. Ohishi, S. Ohm, T. Oka, N. Okazaki, A. Okumura, C. Oliver, G. Olivera, B. Olmi, M. Orienti, R. Orito, M. Orlandini, E. Orlando, J.P. Osborne, M. Ostrowski, N. Otte, E. Ovcharov, E. Owen, I. Oya, A. Ozieblo, M. Padovani, A. Pagliaro, A. Paizis, M. Palatiello, M. Palatka, E. Palazzi, J.‑L. Panazol, D. Paneque, S. Panny, Francesca Romana Pantaleo, M. Panter, M. Paolillo, A. Papitto, A. Paravac, J.M. Paredes, G. Pareschi, N. Parmiggiani, R.D. Parsons, P. Paśko, S. R. Patel, B. Patricelli, L. Pavletic, S. Pavy, A. Peer, M. Pecimotika, M.G. Pellegriti, P. Peñil Del Campo, A. Pepato, S. Perard, C. Perennes, M. Peresano, A. Perez Aguilera, J. Perez Romero, M.A. Perez Torres, M. Persic, P. O. Petrucci, O. Petruk, B. Peyaud, K. Pfrang, E. Pian, P. Piatteli, E. Pietropaolo, R. Pillera, D. Pimentel, F. Pintore, C. Pio Garcia, G. Pirola, F. Piron, S. Pita, M. Pohl, V. Poireau, A. Pollo, M. Polo, C. Pongkitivanichkul, J. Porthault, J. Powell, D. Pozo, R.R. Prado, E. Prandini, J. Prast, K. Pressard, G. Principe, N. Produit, D. Prokhorov, H. Prokoph, H. Przybilski, E. Pueschel, G. Pühlhofer, I. Puljak, M.L. Pumo, M. Punch, F. Queiroz, J. Quinn, A. Quirrenbach, P.J. Rajda, R. Rando, S. Razzaque, S. Recchia, P. Reichherzer, O. Reimer, A. Reisenegger, Q. Remy, M. Renaud, T. Reposeur, B. Reville, J.M. Reymond, J. Reynolds, D. Ribeiro, M. Ribo, G. Richards, J. Rico, F. Rieger, L. Riitano, M. Riquelme, D. Riquelme, S. Rivoire, V. Rizi, E. Roache, M. Roche, J. Rodriguez, G. Rodriguez Fernandez, J.C. Rodriguez Ramirez, J.J. Rodriguez Vazquez, G. Rojas, P. Romano, G. Romeo Lobato, C. Romoli, M. Roncadelli, J. Rosado, A. Rosales de Leon, G. Rowell, A. Rugliancich, J.E. Ruiz del Mazo, C. Rulten, C. Russell, F. Russo Hatlen, S. Safi Harb, L. Saha, V. Sahakian, S. Sailer, T. Saito, N. Sakaki, S. Sakurai, G. Salina, H. Salzmann, D. Sanchez, H. Sandaker, A. Sandoval, P. Sangiorgi, M. Sanguillon, H. Sano, M. Santander, A. Santangelo, R. Santos Lima, A. Sanuy, L. Sapozhnikov, T. Saric, S. Sarkar, H. Sasaki, N. Sasaki, Y. Sato, F.G. Saturni, M. Sawada, J. Schaefer, A. Scherer, J. Scherpenberg, P. Schipani, B. Schleicher, J. Schmoll, M. Schneider, H. Schoorlemmer, P. Schovanek, F. Schussler, B. Schwab, U. Schwanke, J. Schwarz, E. Sciacca, S. Scuderi, M. Seglar Arroyo, I. Seitenzahl, D. Semikoz, O. Sergijenko, J.E. Serna Franco, Karol Seweryn, V. Sguera, A. Shalchi, R.Y. Shang, P. Sharma, L. Sidoli, J. Sieiro, H. Siejkowski, A. Sillanpaa, B.B. Singh, K.K. Singh, A. Sinha, C. Siqueira, J. Sitarek, P. Sizun, V. Sliusar, D. Sobczynska, R.W. Sobrinho, H. Sol, G. Sottile, H. Spackman, S. Spencer, G. Spengler, D. Spiga, W. Springer, A. Stamerra, S. Stanic, R. Starling, Ł. Stawarz, Stanislav Stefanik, C. Stegmann, A. Steiner, S. Steinmassl, C. Stella, R. Sternberger, M. Sterzel, C. Stevens, B. Stevenson, T. Stolarczyk, G. Stratta, U. Straumann, J. Striskovic, M. Strzys, R. Stuik, M. Suchenek, Y. Sunada, Tiina Suomijarvi, T. Suric, H. Suzuki, P. Swierk, T. Szepieniec, K. Tachihara, G. Tagliaferri, H. Tajima, N. Tajima, D. Tak, H. Takahashi, M. Takahashi, J. Takata, R. Takeishi, T. Tam, M. Tanaka, T. Tanaka, S. Tanaka, M. Tavani, F. Tavecchio, T. Tavernier, A. Russ Taylor, L.A. Tejedor, P. Temnikov, K. Terauchi, J.C. Terrazas, R. Terrier, T. Terzic, M. Teshima, D. Thibaut, F. Thocquenne, W. Tian, L. Tibaldo, A. Tiengo, M. Tluczykont, C.J. Todero Peixoto, K. Toma, L. Tomankova, J. Tomastik, M. Tornikoski, D.F. Torres, E. Torresi, G. Tosti, L. Tosti, N. Tothill, F. Toussenel, G. Tovmassian, C. Trichard, M. Trifoglio, A. Trois, S. Truzzi, A. Tsiahina, B. Turk, A. Tutone, Y. Uchiyama, P. Utayarat, L. Vaclavek, M. Vacula, V. Vagelli, F. Vagnetti, J.A. Valdivia, M. Valentino, A. Valio, B. Vallage, P. Vallania Quispe, A.M. van den Berg, W. van Driel, C. van Eldik, C. van Rensburg, Brian van Soelen, J. Vandenbroucke, G. Vasileiadis, V. Vassiliev, M. Vazquez Acosta, M. Vecchi, A. Vega, J. Veh, P. Veitch, C. Venter, S. Ventura, S. Vercellone, V. Verguilov, G. Verna, S. Vernetto, V. Verzi, G.P. Vettolani, C. Veyssiere, I. Viale, A. Viana, N. Viaux, J. Vignatti, C.F. Vigorito, J. Villanueva, V. Vitale, V. Vittorini, V. Vodeb, N. Vogel, V. Voisin, S. Vorobiov, M. Vrastil, T. Vuillaume, S.J. Wagner, P. Wagner, K. Wakazono, S.P. Wakely, M. Ward, D. Warren, J. Watson, M. Wechakama, P. Wegner, A. Weinstein, C. Weniger, F. Werner, H. Wetteskind, M. L. White, A. Wierzcholska, S. Wiesand, R. Wijers, M. Wilkinson, M. Will, J. Williams, T. J. Williamson, A. Wolter, Y.W. Wong, M. Wood, T. Yamamoto, H. Yamamoto, Y. Yamane, R. Yamazaki, S. Yanagita, L. Yang, S. Yoo, T. Yoshida, T. Yoshikoshi, P. Yu, A. Yusafzai, Michael Zacharias, B. Zaldivar, L. Zampieri, R. Zanin, R. Zanmar Sanchez, D. Zaric, M. Zavrtanik, D. Zavrtanik, Andrzej Zdziarski, A. Zech, H. Zechlin, A. Zenin, A. Zerwekh, K. Ziętara, A. Zink, J. Ziolkowski, M. Zivec, A. Zmija, Współautorami artykułu są członkowie CTA Observatory, CTA Consortium i LST Collaboration w liczbie 1139, Astronomy, Research unit Nuclear & Hadron Physics, and Research unit Astroparticle Physics
Subjects: Physics, Observatory, Gamma ray, Astronomy
Abstract: Very-high Energy (VHE) gamma-ray astroparticle physics is a relatively young field, and observations over the past decade have surprisingly revealed almost two hundred VHE emitters which appear to act as cosmic particle accelerators. These sources are an important component of the Universe, influencing the evolution of stars and galaxies. At the same time, they also act as a probe of physics in the most extreme environments known - such as in supernova explosions, and around or after the merging of black holes and neutron stars. However, the existing experiments have provided exciting glimpses, but often falling short of supplying the full answer. A deeper understanding of the TeV sky requires a significant improvement in sensitivity at TeV energies, a wider energy coverage from tens of GeV to hundreds of TeV and a much better angular and energy resolution with respect to the currently running facilities. The next generation gamma-ray observatory, the Cherenkov Telescope Array Observatory (CTAO), is the answer to this need. In this talk I will present this upcoming observatory from its design to the construction, and its potential science exploitation. CTAO will allow the entire astronomical community to explore a new discovery space that will likely lead to paradigm-changing breakthroughs. In particular, CTA has an unprecedented sensitivity to short (sub-minute) timescale phenomena, placing it as a key instrument in the future of multi-messenger and multi-wavelength time domain astronomy. I will conclude the talk presenting the first scientific results obtained by the LST-1, the prototype of one CTAO telescope type - the Large-Sized Telescope, that is currently under commission., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference (ICRC2021)
Published: 2022

5. The Design and Integrated Performance of SPT-3G

Author: J. A. Sobrin, A. J. Anderson, A. N. Bender, B. A. Benson, D. Dutcher, A. Foster, N. Goeckner-Wald, J. Montgomery, A. Nadolski, A. Rahlin, P. A. R. Ade, Z. Ahmed, E. Anderes, M. Archipley, J. E. Austermann, J. S. Avva, K. Aylor, L. Balkenhol, P. S. Barry, R. Basu Thakur, K. Benabed, F. Bianchini, L. E. Bleem, F. R. Bouchet, L. Bryant, K. Byrum, J. E. Carlstrom, F. W. Carter, T. W. Cecil, C. L. Chang, P. Chaubal, G. Chen, H.-M. Cho, T.-L. Chou, J.-F. Cliche, T. M. Crawford, A. Cukierman, C. Daley, T. de Haan, E. V. Denison, K. Dibert, J. Ding, M. A. Dobbs, W. Everett, C. Feng, K. R. Ferguson, J. Fu, S. Galli, A. E. Gambrel, R. W. Gardner, R. Gualtieri, S. Guns, N. Gupta, R. Guyser, N. W. Halverson, A. H. Harke-Hosemann, N. L. Harrington, J. W. Henning, G. C. Hilton, E. Hivon, G. P. Holder, W. L. Holzapfel, J. C. Hood, D. Howe, N. Huang, K. D. Irwin, O. B. Jeong, M. Jonas, A. Jones, T. S. Khaire, L. Knox, A. M. Kofman, M. Korman, D. L. Kubik, S. Kuhlmann, C.-L. Kuo, A. T. Lee, E. M. Leitch, A. E. Lowitz, C. Lu, S. S. Meyer, D. Michalik, M. Millea, T. Natoli, H. Nguyen, G. I. Noble, V. Novosad, Y. Omori, S. Padin, Z. Pan, P. Paschos, J. Pearson, C. M. Posada, K. Prabhu, W. Quan, C. L. Reichardt, D. Riebel, B. Riedel, M. Rouble, J. E. Ruhl, B. Saliwanchik, J. T. Sayre, E. Schiappucci, E. Shirokoff, G. Smecher, A. A. Stark, J. Stephen, K. T. Story, A. Suzuki, C. Tandoi, K. L. Thompson, B. Thorne, C. Tucker, C. Umilta, L. R. Vale, K. Vanderlinde, J. D. Vieira, G. Wang, N. Whitehorn, W. L. K. Wu, V. Yefremenko, K. W. Yoon, M. R. Young, Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and SPT-3G
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), Space and Planetary Science, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 7. Clean energy, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: SPT-3G is the third survey receiver operating on the South Pole Telescope dedicated to high-resolution observations of the cosmic microwave background (CMB). Sensitive measurements of the temperature and polarization anisotropies of the CMB provide a powerful dataset for constraining cosmology. Additionally, CMB surveys with arcminute-scale resolution are capable of detecting galaxy clusters, millimeter-wave bright galaxies, and a variety of transient phenomena. The SPT-3G instrument provides a significant improvement in mapping speed over its predecessors, SPT-SZ and SPTpol. The broadband optics design of the instrument achieves a 430 mm diameter image plane across observing bands of 95 GHz, 150 GHz, and 220 GHz, with 1.2 arcmin FWHM beam response at 150 GHz. In the receiver, this image plane is populated with 2690 dual-polarization, tri-chroic pixels (~16000 detectors) read out using a 68X digital frequency-domain multiplexing readout system. In 2018, SPT-3G began a multiyear survey of 1500 deg$^{2}$ of the southern sky. We summarize the unique optical, cryogenic, detector, and readout technologies employed in SPT-3G, and we report on the integrated performance of the instrument., Comment: 25 pages, 11 figures. Accepted for publication in ApJS
Published: 2021

6. Defining and Modulating ‘BRCAness’

Author: Nima Mosammaparast, Alessandro Vindigni, and Andrea K. Byrum
Subjects: Genome instability, DNA Repair, Poly ADP ribose polymerase, Synthetic lethality, Computational biology, Poly(ADP-ribose) Polymerase Inhibitors, Genomic Instability, Replication fork protection, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Humans, Homologous Recombination, Polymerase, 030304 developmental biology, BRCA2 Protein, 0303 health sciences, biology, BRCA1 Protein, Cell Cycle Checkpoints, Cell Biology, G2-M DNA damage checkpoint, biology.protein, Homologous recombination, 030217 neurology & neurosurgery, Function (biology), DNA Damage
Abstract: The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased genomic instability, which may be responsible for their sensitivity to DNA damaging agents and poly-(ADP)-ribose polymerase inhibitors (PARPis). However, recent work has expanded the mechanistic basis of BRCAness, to include defects in replication fork protection (RFP). Here, we broaden the definition of BRCAness to include RFP and regulatory mechanisms that cause synthetic lethality with PARPis. We highlight these recent discoveries, which include mechanisms of RFP regulation, DNA damage checkpoint proteins, as well as kinases that regulate BRCA1/2 function. Importantly, many of these emerging mechanisms may be targeted for inhibition with small molecule inhibitors, thus inducing BRCAness in a much larger subset of BRCA-proficient tumors, with significant translational potential.
Published: 2019
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7. XLF and H2AX function in series to promote replication fork stability

Author: Andrea L. Bredemeyer, Matteo Berti, Issa Hindi, Jessica K. Tyler, Saravanabhavan Thangavel, Barry P. Sleckman, Andrea K. Byrum, Annabel Quinet, Alessandro Vindigni, Nima Mosammaparast, Bo-Ruei Chen, and Jessica Jackson
Subjects: DNA Replication, DNA End-Joining Repair, DNA Repair, DNA damage, Ataxia Telangiectasia Mutated Proteins, Biology, environment and public health, Histones, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Replication factor C, Commentaries, Report, Animals, DNA Breaks, Double-Stranded, Phosphorylation, Spotlight, Research Articles, 030304 developmental biology, MRE11 Homologue Protein, 0303 health sciences, DNA replication, Cell Biology, Fibroblasts, DNA Replication Fork, Double Strand Break Repair, 3. Good health, Cell biology, DNA-Binding Proteins, enzymes and coenzymes (carbohydrates), chemistry, Replisome, biological phenomena, cell phenomena, and immunity, Cell Division, 030217 neurology & neurosurgery, DNA, DNA Damage
Abstract: Chen et al. show that XLF functions to limit fork reversal during DNA replication. H2AX prevents MRE11-dependent replication stress in XLF-deficient cells, suggesting that H2AX prevents the resection of regressed arms at reversed forks., XRCC4-like factor (XLF) is a non-homologous end joining (NHEJ) DNA double strand break repair protein. However, XLF deficiency leads to phenotypes in mice and humans that are not necessarily consistent with an isolated defect in NHEJ. Here we show that XLF functions during DNA replication. XLF undergoes cell division cycle 7–dependent phosphorylation; associates with the replication factor C complex, a critical component of the replisome; and is found at replication forks. XLF deficiency leads to defects in replication fork progression and an increase in fork reversal. The additional loss of H2AX, which protects DNA ends from resection, leads to a requirement for ATR to prevent an MRE11-dependent loss of newly synthesized DNA and activation of DNA damage response. Moreover, H2ax−/−:Xlf−/− cells exhibit a marked dependence on the ATR kinase for survival. We propose that XLF and H2AX function in series to prevent replication stress induced by the MRE11-dependent resection of regressed arms at reversed replication forks.
Published: 2019
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8. Asteroid Measurements at Millimeter Wavelengths with the South Pole Telescope

Author: P. M. Chichura, A. Foster, C. Patel, N. Ossa-Jaen, P. A. R. Ade, Z. Ahmed, A. J. Anderson, M. Archipley, J. E. Austermann, J. S. Avva, L. Balkenhol, P. S. Barry, R. Basu Thakur, J. A. Beall, K. Benabed, A. N. Bender, B. A. Benson, F. Bianchini, L. E. Bleem, F. R. Bouchet, L. Bryant, K. Byrum, J. E. Carlstrom, F. W. Carter, T. W. Cecil, C. L. Chang, P. Chaubal, G. Chen, H. C. Chiang, H.-M. Cho, T-L. Chou, R. Citron, J.-F. Cliche, T. M. Crawford, A. T. Crites, A. Cukierman, C. M. Daley, E. V. Denison, K. Dibert, J. Ding, M. A. Dobbs, D. Dutcher, W. Everett, C. Feng, K. R. Ferguson, J. Fu, S. Galli, J. Gallicchio, A. E. Gambrel, R. W. Gardner, E. M. George, N. Goeckner-Wald, R. Gualtieri, S. Guns, N. Gupta, R. Guyser, T. de Haan, N. W. Halverson, A. H. Harke-Hosemann, N. L. Harrington, J. W. Henning, G. C. Hilton, E. Hivon, G. P. Holder, W. L. Holzapfel, J. C. Hood, D. Howe, J. D. Hrubes, N. Huang, J. Hubmayr, K. D. Irwin, O. B. Jeong, M. Jonas, A. Jones, T. S. Khaire, L. Knox, A. M. Kofman, M. Korman, D. L. Kubik, S. Kuhlmann, C.-L. Kuo, A. T. Lee, E. M. Leitch, D. Li, A. Lowitz, C. Lu, D. P. Marrone, J. J. McMahon, S. S. Meyer, D. Michalik, M. Millea, L. M. Mocanu, J. Montgomery, C. Corbett Moran, A. Nadolski, T. Natoli, H. Nguyen, J. P. Nibarger, G. Noble, V. Novosad, Y. Omori, S. Padin, Z. Pan, P. Paschos, S. Patil, J. Pearson, K. A. Phadke, C. M. Posada, K. Prabhu, C. Pryke, W. Quan, A. Rahlin, C. L. Reichardt, D. Riebel, B. Riedel, M. Rouble, J. E. Ruhl, B. R. Saliwanchik, J. T. Sayre, K. K. Schaffer, E. Schiappucci, E. Shirokoff, C. Sievers, G. Smecher, J. A. Sobrin, A. Springmann, A. A. Stark, J. Stephen, K. T. Story, A. Suzuki, C. Tandoi, K. L. Thompson, B. Thorne, C. Tucker, C. Umilta, L. R. Vale, T. Veach, J. D. Vieira, G. Wang, N. Whitehorn, W. L. K. Wu, V. Yefremenko, K. W. Yoon, and M. R. Young
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: We present the first measurements of asteroids in millimeter wavelength (mm) data from the South Pole Telescope (SPT), which is used primarily to study the cosmic microwave background (CMB). We analyze maps of two $\sim270$ deg$^2$ sky regions near the ecliptic plane, each observed with the SPTpol camera $\sim100$ times over one month. We subtract the mean of all maps of a given field, removing static sky signal, and then average the mean-subtracted maps at known asteroid locations. We detect three asteroids$\text{ -- }$(324) Bamberga, (13) Egeria, and (22) Kalliope$\text{ -- }$with signal-to-noise ratios (S/N) of 11.2, 10.4, and 6.1, respectively, at 2.0 mm (150 GHz); we also detect (324) Bamberga with S/N of 4.1 at 3.2 mm (95 GHz). We place constraints on these asteroids' effective emissivities, brightness temperatures, and light curve modulation amplitude. Our flux density measurements of (324) Bamberga and (13) Egeria roughly agree with predictions, while our measurements of (22) Kalliope suggest lower flux, corresponding to effective emissivities of $0.66 \pm 0.11$ at 2.0 mm and $, 21 pages, 9 figures
Published: 2022
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9. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

Author: Jesse C. Crow, Andrea K Byrum, Benjamin Sunkel, Stephen L. Lessnick, Cenny Taslim, Benjamin Z. Stanton, Emily R. Theisen, Meng Wang, Julia Selich-Anderson, Megann A. Boone, and Iftekhar A. Showpnil
Subjects: 0301 basic medicine, Cancer Research, Mutant, Chromosomal translocation, Sarcoma, Ewing, Biology, medicine.disease_cause, Article, Paediatric cancer, 03 medical and health sciences, 0302 clinical medicine, Phagocytosis, Transcription (biology), Genetics, Transcriptional regulation, medicine, Bone cancer, Humans, Child, Molecular Biology, fungi, Sarcoma, Oncogenes, Fusion protein, Chromatin, Cell biology, 030104 developmental biology, Mechanisms of disease, 030220 oncology & carcinogenesis, Carcinogenesis, Transcription, Function (biology)
Abstract: Ewing sarcoma is an aggressive bone cancer of children and young adults defined by the presence of a chromosomal translocation: t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses the amino-terminal domain of EWS to the carboxyl-terminus of FLI. The EWS portion is an intrinsically disordered transcriptional regulatory domain, while the FLI portion contains an ETS DNA-binding domain and two flanking regions of unknown function. Early studies using non-Ewing sarcoma models provided conflicting information on the roles of each domain of FLI in EWS/FLI oncogenic function. We therefore sought to define the specific contributions of each FLI domain to EWS/FLI activity in a well-validated Ewing sarcoma model and, in doing so, to better understand Ewing sarcoma development mediated by the fusion protein. We analyzed a series of engineered EWS/FLI mutants with alterations in the FLI portion using a variety of assays. Fluorescence anisotropy, CUT&RUN, and ATAC-sequencing experiments revealed that the isolated ETS domain is sufficient to maintain the normal DNA-binding and chromatin accessibility function of EWS/FLI. In contrast, RNA-sequencing and soft agar colony formation assays revealed that the ETS domain alone was insufficient for transcriptional regulatory and oncogenic transformation functions of the fusion protein. We found that an additional alpha-helix immediately downstream of the ETS domain is required for full transcriptional regulation and EWS/FLI-mediated oncogenesis. These data demonstrate a previously unknown role for FLI in transcriptional regulation that is distinct from its DNA-binding activity. This activity is critical for the cancer-causing function of EWS/FLI and may lead to novel therapeutic approaches.
Published: 2020

10. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

Author: Michael Field, Patrick M. Lombardi, Renana Rabe, Clement Oyeniran, Jozef Gecz, Jessica Jackson, Yu Zhao, Cathrine Broberg Vågbø, Geir Slupphaug, Meagan E Sullender, Cynthia Wolberger, Joshua R. Brickner, Jennifer M. Soll, Alessandro Vindigni, Elyse M Blazosky, Nima Mosammaparast, Mark A. Corbett, Andrea K. Byrum, and Miranda C. Mudge
Subjects: Models, Molecular, 0301 basic medicine, Alkylating Agents, Alkylation, DNA Repair, DNA repair, DNA damage, RNA Splicing, Endoplasmic Reticulum, medicine.disease_cause, Article, DNA Adducts, 03 medical and health sciences, chemistry.chemical_compound, Ubiquitin, Genes, X-Linked, medicine, Humans, Trichothiodystrophy Syndromes, Amino Acid Sequence, Polyubiquitin, Mutation, Multidisciplinary, biology, AlkB Enzymes, DNA Helicases, Ubiquitination, Nuclear Proteins, 3. Good health, Ubiquitin ligase, Cell biology, DNA-Binding Proteins, RNF113A, Kinetics, DNA Alkylation, 030104 developmental biology, chemistry, Biochemistry, Multiprotein Complexes, biology.protein, AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase, RNA Polymerase II, DNA, Signal Transduction
Abstract: DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical mechanisms for repairing several forms of genomic insults are well understood, the upstream signalling pathways that trigger repair are established for only certain types of damage, such as double-stranded breaks and interstrand crosslinks. Understanding the upstream signalling events that mediate recognition and repair of DNA alkylation damage is particularly important, since alkylation chemotherapy is one of the most widely used systemic modalities for cancer treatment and because environmental chemicals may trigger DNA alkylation. Here we demonstrate that human cells have a previously unrecognized signalling mechanism for sensing damage induced by alkylation. We find that the alkylation repair complex ASCC (activating signal cointegrator complex) relocalizes to distinct nuclear foci specifically upon exposure of cells to alkylating agents. These foci associate with alkylated nucleotides, and coincide spatially with elongating RNA polymerase II and splicing components. Proper recruitment of the repair complex requires recognition of K63-linked polyubiquitin by the CUE (coupling of ubiquitin conjugation to ER degradation) domain of the subunit ASCC2. Loss of this subunit impedes alkylation adduct repair kinetics and increases sensitivity to alkylating agents, but not other forms of DNA damage. We identify RING finger protein 113A (RNF113A) as the E3 ligase responsible for upstream ubiquitin signalling in the ASCC pathway. Cells from patients with X-linked trichothiodystrophy, which harbour a mutation in RNF113A, are defective in ASCC foci formation and are hypersensitive to alkylating agents. Together, our work reveals a previously unrecognized ubiquitin-dependent pathway induced specifically to repair alkylation damage, shedding light on the molecular mechanism of X-linked trichothiodystrophy.
Published: 2017
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11. 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Author: Jeremy M. Stark, Andrea K. Byrum, Elsa Callen, Nancy Wong, Andre Stanlie, Yaakov Maman, Nima Mosammaparast, Raphael Souza Pavani, Michael J. Kruhlak, Amanda Day, Wei Wu, André Nussenzweig, Lavinia C. Dumitrache, Peter J. McKinnon, Dali Zong, Andres Canela, Maria A. Blasco, Carlos Mendez-Dorantes, Paula Martinez, and Momoko Ishikawa
Subjects: Premature aging, Genome instability, Aging, DNA damage, Ubiquitin-Protein Ligases, RAD51, Poly(ADP-ribose) Polymerase Inhibitors, Biology, medicine.disease_cause, Article, Genomic Instability, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, DNA Breaks, Double-Stranded, Homologous Recombination, Molecular Biology, 030304 developmental biology, 0303 health sciences, Mutation, BRCA1 Protein, Effector, Cell Biology, Cell biology, chemistry, Rad51 Recombinase, Tumor Suppressor p53-Binding Protein 1, Homologous recombination, 030217 neurology & neurosurgery, DNA, DNA Damage
Abstract: Summary 53BP1 activity drives genome instability and lethality in BRCA1-deficient mice by inhibiting homologous recombination (HR). The anti-recombinogenic functions of 53BP1 require phosphorylation-dependent interactions with PTIP and RIF1/shieldin effector complexes. While RIF1/shieldin blocks 5′-3′ nucleolytic processing of DNA ends, it remains unclear how PTIP antagonizes HR. Here, we show that mutation of the PTIP interaction site in 53BP1 (S25A) allows sufficient DNA2-dependent end resection to rescue the lethality of BRCA1Δ11 mice, despite increasing RIF1 “end-blocking” at DNA damage sites. However, double-mutant cells fail to complete HR, as excessive shieldin activity also inhibits RNF168-mediated loading of PALB2/RAD51. As a result, BRCA1Δ1153BP1S25A mice exhibit hallmark features of HR insufficiency, including premature aging and hypersensitivity to PARPi. Disruption of shieldin or forced targeting of PALB2 to ssDNA in BRCA1D1153BP1S25A cells restores RNF168 recruitment, RAD51 nucleofilament formation, and PARPi resistance. Our study therefore reveals a critical function of shieldin post-resection that limits the loading of RAD51.
Published: 2020
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12. Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing

Author: Nima Mosammaparast, Denisse Carvajal-Maldonado, Susana Gonzalo, Jean-Yves Masson, Laure Guitton-Sert, Alessandro Vindigni, Jessica Jackson, Stephanie Tirman, Annabel Quinet, David Cortez, Sarah R. Wessel, Delphine Lemaçon, Simona Graziano, and Andrea K. Byrum
Subjects: DNA Replication, Cohesin complex, Chromosomal Proteins, Non-Histone, Cell Cycle Proteins, Biology, Chromatids, Genome Integrity, Repair and Replication, DNA-binding protein, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Genetics, Humans, 030304 developmental biology, BRCA2 Protein, 0303 health sciences, MRE11 Homologue Protein, Deoxyribonucleases, Cohesin, DNA replication, Nuclear Proteins, DNA Replication Fork, Phosphoproteins, Cell biology, Establishment of sister chromatid cohesion, DNA-Binding Proteins, chemistry, Chromatid, biological phenomena, cell phenomena, and immunity, Sister Chromatid Exchange, 030217 neurology & neurosurgery, DNA, DNA Damage
Abstract: Pds5 is required for sister chromatid cohesion, and somewhat paradoxically, to remove cohesin from chromosomes. We found that Pds5 plays a critical role during DNA replication that is distinct from its previously known functions. Loss of Pds5 hinders replication fork progression in unperturbed human and mouse cells. Inhibition of MRE11 nuclease activity restores fork progression, suggesting that Pds5 protects forks from MRE11-activity. Loss of Pds5 also leads to double-strand breaks, which are again reduced by MRE11 inhibition. The replication function of Pds5 is independent of its previously reported interaction with BRCA2. Unlike Pds5, BRCA2 protects forks from nucleolytic degradation only in the presence of genotoxic stress. Moreover, our iPOND analysis shows that the loading of Pds5 and other cohesion factors on replication forks is not affected by the BRCA2 status. Pds5 role in DNA replication is shared by the other cohesin-removal factor Wapl, but not by the cohesin complex component Rad21. Interestingly, depletion of Rad21 in a Pds5-deficient background rescues the phenotype observed upon Pds5 depletion alone. These findings support a model where loss of either component of the cohesin releasin complex perturbs cohesin dynamics on replication forks, hindering fork progression and promoting MRE11-dependent fork slowing.
Published: 2018

13. Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function

Author: Romil Patel, Mona C. Majid, Nima Mosammaparast, Denisse Carvajal-Maldonado, J. Wade Harper, Mathew E. Sowa, Andrea K. Byrum, David Valle-Garcia, Steven P. Gygi, Miranda C. Mudge, Alessandro Vindigni, and Yang Shi
Subjects: DNA Replication, DNA Repair, DNA damage, RAD51, Mitosis, Cell Cycle Proteins, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Report, Commentaries, Animals, Humans, DNA Breaks, Double-Stranded, Spotlight, Homologous Recombination, Research Articles, 030304 developmental biology, Aurora Kinase A, 0303 health sciences, Nuclease, MRE11 Homologue Protein, biology, BRCA1 Protein, DNA replication, DNA, Cell Biology, Cell biology, enzymes and coenzymes (carbohydrates), chemistry, 030220 oncology & carcinogenesis, biology.protein, Rad51 Recombinase, Homologous recombination, Tumor Suppressor p53-Binding Protein 1, Microtubule-Associated Proteins, Function (biology), HeLa Cells
Abstract: The TPX2/Aurora A heterodimeric kinase canonically orchestrates mitotic events. Byrum et al. identify two new roles for this complex in regulating DNA double-stranded break repair and the protection of DNA forks during replication stress., 53BP1 is a chromatin-associated protein that regulates the DNA damage response. In this study, we identify the TPX2/Aurora A heterodimer, nominally considered a mitotic kinase complex, as a novel binding partner of 53BP1. We find that TPX2/Aurora A plays a previously unrecognized role in DNA damage repair and replication fork stability by counteracting 53BP1 function. Loss of TPX2 or Aurora A compromises DNA end resection, BRCA1 and Rad51 recruitment, and homologous recombination. Furthermore, loss of TPX2 or Aurora A causes deprotection of stalled replication forks upon replication stress induction. This fork protection pathway counteracts MRE11 nuclease activity but functions in parallel to BRCA1. Strikingly, concurrent loss of 53BP1 rescues not only BRCA1/Rad51 recruitment but also the fork instability induced upon TPX2 loss. Our work suggests the presence of a feedback mechanism by which 53BP1 is regulated by a novel binding partner and uncovers a unique role for 53BP1 in replication fork stability.
Published: 2018

14. OTUD4 is a phospho-activated K63 deubiquitinase that regulates MyD88-dependent signaling

Author: Jennifer M. Soll, Nima Mosammaparast, Steven P. Gygi, Elizabeth A. Schwarzkopf, Rachel B. Rodrigues, Yu Zhao, Miranda C. Mudge, Tara R. Bradstreet, Brian T. Edelson, and Andrea K. Byrum
Subjects: 0301 basic medicine, DNA damage, Article, Deubiquitinating enzyme, 03 medical and health sciences, Mice, Ubiquitin, Animals, Humans, Phosphorylation, Receptor, Molecular Biology, biology, Deubiquitinating Enzymes, Macrophages, Autophagy, HEK 293 cells, Toll-Like Receptors, Ubiquitination, Cell Biology, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, HEK293 Cells, Myeloid Differentiation Factor 88, Proteolysis, biology.protein, Ubiquitin-Specific Proteases, Signal transduction, Signal Transduction
Abstract: Ubiquitination is a major mechanism that regulates numerous cellular processes, including autophagy, DNA damage signaling, and inflammation. While hundreds of ubiquitin ligases exist to conjugate ubiquitin onto substrates, approximately one hundred deubiquitinases are encoded by the human genome. Thus, deubiquitinases are likely regulated by unidentified mechanisms to target distinct substrates and cellular functions. Here, we demonstrate that the deubiquitinase OTUD4, which nominally encodes a K48-specific deubiquitinase, is phosphorylated near its catalytic domain, activating a latent K63-specific deubiquitinase. Besides phosphorylation, this latter activity requires an adjacent ubiquitin-interacting motif, which increases the affinity of OTUD4 for K63-linked chains. We reveal the Toll-like receptor (TLR) associated factor MyD88 as a target of this K63 deubiquitinase activity. Consequently, TLR-mediated activation of NF-κB is negatively regulated by OTUD4, and macrophages from Otud4(−/−) mice exhibit increased inflammatory signaling upon TLR stimulation. Our results reveal insights into how a deubiquitinase may modulate diverse processes through post-translational modification.
Published: 2018

15. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining

Author: Shruthi Deivasigamani, Michael L. Gross, Gaya K. Amarasinghe, Shan Zha, John J.H. Petrini, Barry P. Sleckman, Nima Mosammaparast, Bo-Ruei Chen, Brian J. Lee, Putzer J Hung, David J. Pisapia, Jayanta Chaudhuri, Jessica K. Tyler, Tanya E. Johnson, Britney Johnson, Parmeshwar Amatya, Andrea K. Byrum, Andrea L. Bredemeyer, Issa Hindi, William T. Yewdell, and Tanya T. Paull
Subjects: 0301 basic medicine, DNA End-Joining Repair, Ku80, DNA Repair, DNA damage, Cell Cycle Proteins, Biology, Article, DNA Ligase ATP, Mice, 03 medical and health sciences, Animals, Humans, DNA Breaks, Double-Stranded, Ku Autoantigen, Molecular Biology, chemistry.chemical_classification, DNA ligase, Ku70, 030102 biochemistry & molecular biology, Signal transducing adaptor protein, Cell Biology, DNA repair protein XRCC4, Chromatin, Cell biology, DNA-Binding Proteins, Non-homologous end joining, DNA Repair Enzymes, 030104 developmental biology, chemistry
Abstract: The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI is intrinsically disordered and interacts with many DNA damage response (DDR) proteins, including the kinases ataxia telangiectasia mutated (ATM) and DNA-PKcs and the classical non-homologous end joining (cNHEJ) factors Ku70, Ku80, XRCC4, XLF, PAXX, and XRCC4. MRI forms large multimeric complexes that depend on its N and C termini and localizes to DNA double-strand breaks (DSBs), where it promotes the retention of DDR factors. Mice deficient in MRI and XLF exhibit embryonic lethality at a stage similar to those deficient in the core cNHEJ factors XRCC4 or DNA ligase IV. Moreover, MRI is required for cNHEJ-mediated DSB repair in XLF-deficient lymphocytes. We propose that MRI is an adaptor that, through multivalent interactions, increases the avidity of DDR factors to DSB-associated chromatin to promote cNHEJ.
Published: 2018
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16. OBSERVATIONS OF THE SHELL-TYPE SUPERNOVA REMNANT CASSIOPEIA A AT TeV ENERGIES WITH VERITAS

Author: R. G. Wagner, Gernot Maier, Stephanie Wissel, C. M. Hui, M. J. Lang, S. P. Wakely, T. B. Humensky, Daniel Gall, B. R. Smith, Geza Gyuk, Y. Butt, D. Boltuch, J. E. Ward, A. Cesarini, John L. Quinn, R. Dickherber, A. J.R. Weinstein, M. Bautista, S. Thibadeau, S. McArthur, V. A. Acciari, D. S. Hanna, David Kieda, J. P. Finley, R. A. Ong, Thomas Weisgarber, N. Karlsson, Jamie Holder, A. McCann, Martin Pohl, Wystan Benbow, T. C. Weekes, M. Beilicke, D. Steele, R. Guenette, V. Bugaev, S. LeBohec, F. Krennrich, E. Roache, P. Fortin, H. J. Rose, J. Grube, A. Furniss, S. P. Swordy, J. Millis, K. Byrum, Matthew J.A. Wood, Tulun Ergin, P. Moriarty, Nicola Galante, J. S. Perkins, M. Kertzman, S. J. Fegan, S. Vincent, M. Schroedter, G. H. Sembroski, P. T. Reynolds, Lucy Fortson, A. Varlotta, Wei Cui, D. Huang, M. Theiling, P. Cogan, T. Aune, Y. C. Chow, V. V. Vassiliev, P. Kaaret, G. Finnegan, A. W. Smith, C. Duke, J. H. Buckley, A. Konopelko, G. H. Gillanders, T. Arlen, L. Ciupik, E. Aliu, H. Krawczynski, K. Ragan, S. M. Bradbury, A. Cannon, D. Pandel, and M. McCutcheon
Subjects: Photon, Astrophysics::High Energy Astrophysical Phenomena, cosmic-rays, Shell (structure), Flux, Astrophysics, 01 natural sciences, Power law, cosmic rays, 0103 physical sciences, air cerenkov telescopes, crab-nebula, Supernova remnant, ism: individual objects (cassiopeia a), 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Cherenkov radiation, acceleration of particles, Physics, magnetic-fields, electron acceleration, particle-acceleration, 010308 nuclear & particles physics, Astrophysics::Instrumentation and Methods for Astrophysics, Gamma ray, Astronomy and Astrophysics, gamma-ray emission, Cassiopeia A, gamma rays: ism, rx j1713.7-3946, 13. Climate action, Space and Planetary Science, ism: supernova remnants, a supernova, magic telescope
Abstract: We report on observations of very high energy gamma rays from the shell-type supernova remnant (SNR) Cassiopeia A with the Very Energetic Radiation Imaging Telescope Array System stereoscopic array of four imaging atmospheric Cherenkov telescopes in Arizona. The total exposure time for these observations is 22 hr, accumulated between September and November of 2007. The gamma-ray source associated with the SNR Cassiopeia A was detected above 200 GeV with a statistical significance of 8.3 sigma. The estimated integral flux for this gamma-ray source is about 3% of the Crab-Nebula flux. The photon spectrum is compatible with a power law dN/dE proportional to E(-Gamma) with an index Gamma = 2.61 +/- 0.24(stat) +/- 0.2(sys). The data are consistent with a point-like source. We provide a detailed description of the analysis results and discuss physical mechanisms that may be responsible for the observed gamma-ray emission.
Published: 2010
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17. OBSERVATION OF EXTENDED VERY HIGH ENERGY EMISSION FROM THE SUPERNOVA REMNANT IC 443 WITH VERITAS

Author: R. A. Ong, Thomas Weisgarber, S. LeBohec, S. M. Bradbury, A. Cannon, D. Pandel, D. Horan, P. Cogan, J. Grube, David Kieda, L. Ciupik, P. T. Reynolds, A. McCann, Lucy Fortson, M. Kertzman, M. K. Daniel, E. Aliu, H. Krawczynski, A. Varlotta, Gernot Maier, S. P. Swordy, V. V. Vassiliev, Martin Pohl, S. P. Wakely, Daniel Gall, K. Ragan, M. Wood, M. Beilicke, G. Finnegan, T. B. Humensky, A. W. Smith, B. Zitzer, A. Konopelko, R. G. Wagner, C. Duke, M. Schroedter, L. Valcarcel, Vikram V. Dwarkadas, P. Moriarty, Geza Gyuk, A. Weinstein, T. Arlen, P. Colin, A. N. Otte, A. Furniss, J. H. Buckley, P. Kaaret, Tulun Ergin, F. Krennrich, P. Fortin, S. Vincent, D. S. Hanna, Wystan Benbow, M. Theiling, C. M. Hui, Y. Butt, J. P. Finley, V. Bugaev, G. H. Sembroski, J. A. Toner, T. C. Weekes, R. Dickherber, A. Imran, E. Hays, J. S. Perkins, John Kildea, D. A. Williams, R. Guenette, J. Millis, O. Celik, K. Byrum, Wei Cui, Stephanie Wissel, T. Aune, Y. C. K. Chow, S. J. Fegan, D. Steele, V. A. Acciari, M. J. Lang, H. J. Rose, N. Karlsson, A. Cesarini, John L. Quinn, M. Bautista, K. G. Gibbs, Jamie Holder, L. C. Reyes, E. Roache, J. E. Ward, G. H. Gillanders, S. Godambe, M. McCutcheon, and OpenMETU
Subjects: Physics, nebula, 010308 nuclear & particles physics, ic-443, Molecular cloud, cosmic-rays, Flux, Astronomy and Astrophysics, Context (language use), xmm-newton observations, molecular clouds, Astrophysics, gamma-ray emission, 01 natural sciences, Pulsar wind nebula, ism: individual (ic 443=ver j0616.9+2230, = magic j0616+225), radiation, Space and Planetary Science, 0103 physical sciences, Supernova remnant, 010303 astronomy & astrophysics, gamma rays: observations, magic telescope, discovery, pulsar
Abstract: We present evidence that the very high energy (VHE, E > 100 GeV) gamma-ray emission coincident with the supernova remnant IC 443 is extended. IC 443 contains one of the best studied sites of supernova remnant/molecular cloud interaction and the pulsar wind nebula CXOU J061705.3+222127, both of which are important targets for VHE observations. VERITAS observed IC 443 for 37.9 hr during 2007 and detected emission above 300 GeV with an excess of 247 events, resulting in a significance of 8.3 standard deviations (sigma) before trials and 7.5 sigma after trials in a point-source search. The emission is centered at 6(h)16(m)51(s)+22 degrees 30'11 '' (J2000)+/- 0 degrees.03(stat)+/- 0 degrees.08(sys), with an intrinsic extension of 0 degrees.16 +/- 0 degrees.03(stat)+/- 0 degrees.04(sys). The VHE spectrum is well fit by a power law (dN/dE = N(0) x(E/TeV)(-Gamma)) with a photon index of 2.99 +/- 0.38(stat)+/- 0.3(sys) and an integral flux above 300 GeV of (4.63 +/- 0.90(stat)+/- 0.93(sys)) x 10(-12) cm(-2) s(-1). These results are discussed in the context of existing models for gamma-ray production in IC 443.
Published: 2009
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18. EVIDENCE FOR LONG-TERM GAMMA-RAY AND X-RAY VARIABILITY FROM THE UNIDENTIFIED TeV SOURCE HESS J0632+057

Author: V. A. Acciari, E. Aliu, T. Arlen, M. Beilicke, W. Benbow, D. Boltuch, S. M. Bradbury, J. H. Buckley, V. Bugaev, K. Byrum, A. Cannon, A. Cesarini, Y. C. Chow, L. Ciupik, P. Cogan, R. Dickherber, C. Duke, T. Ergin, A. Falcone, S. J. Fegan, J. P. Finley, G. Finnegan, P. Fortin, L. Fortson, A. Furniss, K. Gibbs, G. H. Gillanders, J. Grube, R. Guenette, G. Gyuk, D. Hanna, J. Holder, D. Horan, C. M. Hui, T. B. Humensky, A. Imran, P. Kaaret, N. Karlsson, M. Kertzman, D. Kieda, J. Kildea, A. Konopelko, H. Krawczynski, F. Krennrich, M. J. Lang, S. LeBohec, G. Maier, A. McCann, M. McCutcheon, J. Millis, P. Moriarty, R. Mukherjee, R. A. Ong, A. N. Otte, D. Pandel, J. S. Perkins, D. Petry, M. Pohl, J. Quinn, K. Ragan, L. C. Reyes, P. T. Reynolds, H. J. Rose, M. Schroedter, G. H. Sembroski, A. W. Smith, D. Steele, S. Swordy, M. Theiling, J. A. Toner, A. Varlotta, V. V. Vassiliev, S. Vincent, R. G. Wagner, S. P. Wakely, J. E. Ward, T. C. Weekes, A. Weinstein, T. Weisgarber, D. A. Williams, S. Wissel, and M. Wood
Subjects: stars, catalog, Be star, Astrophysics::High Energy Astrophysical Phenomena, binary, FOS: Physical sciences, Astrophysics, telescope, 01 natural sciences, emission, 0103 physical sciences, 010303 astronomy & astrophysics, acceleration of particles, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 010308 nuclear & particles physics, stars: individual (hess j0632+057, mwc 148), Gamma ray, X-ray, Astronomy and Astrophysics, Crab Nebula, binaries: general, Space and Planetary Science, Astrophysics - High Energy Astrophysical Phenomena, gamma rays: observations, discovery
Abstract: HESS J0632+057 is one of only two unidentified very-high-energy gamma-ray sources which appear to be point-like within experimental resolution. It is possibly associated with the massive Be star MWC 148 and has been suggested to resemble known TeV binary systems like LS I +61 303 or LS 5039. HESS J0632+057 was observed by VERITAS for 31 hours in 2006, 2008 and 2009. During these observations, no significant signal in gamma rays with energies above 1 TeV was detected from the direction of HESS J0632+057. A flux upper limit corresponding to 1.1% of the flux of the Crab Nebula has been derived from the VERITAS data. The non-detection by VERITAS excludes with a probability of 99.993% that HESS J0632+057 is a steady gamma-ray emitter. Contemporaneous X-ray observations with Swift XRT reveal a factor of 1.8+-0.4 higher flux in the 1-10 keV range than earlier X-ray observations of HESS J0632+057. The variability in the gamma-ray and X-ray fluxes supports interpretation of the ob ject as a gamma-ray emitting binary., Comment: 8 pages, 3 figures, Accepted for publication in The Astrophysical Journal
Published: 2009
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19. THE JUNE 2008 FLARE OF MARKARIAN 421 FROM OPTICAL TO TeV ENERGIES

Author: I. Donnarumma, V. Vittorini, S. Vercellone, E. Del Monte, M. Feroci, F. D'Ammando, L. Pacciani, A. W. Chen, M. Tavani, A. Bulgarelli, A. Giuliani, F. Longo, G. Pucella, A. Argan, G. Barbiellini, F. Boffelli, P. Caraveo, P. W. Cattaneo, V. Cocco, E. Costa, G. De Paris, G. Di Cocco, Y. Evangelista, M. Fiorini, T. Froysland, M. Frutti, F. Fuschino, M. Galli, F. Gianotti, C. Labanti, I. Lapshov, F. Lazzarotto, P. Lipari, M. Marisaldi, M. Mastropietro, S. Mereghetti, E. Morelli, A. Morselli, A. Pellizzoni, F. Perotti, P. Picozza, G. Porrovecchio, M. Prest, M. Rapisarda, A. Rappoldi, A. Rubini, P. Soffitta, M. Trifoglio, A. Trois, E. Vallazza, A. Zambra, D. Zanello, C. Pittori, P. Santolamazza, F. Verrecchia, P. Giommi, S. Colafrancesco, L. Salotti, M. Villata, C. M. Raiteri, W. P. Chen, N. V. Efimova, B. Jordan, T. S. Konstantinova, E. Koptelova, O. M. Kurtanidze, V. M. Larionov, J. A. Ros, A. C. Sadun, H. Anderhub, L. A. Antonelli, P. Antoranz, M. Backes, C. Baixeras, S. Balestra, J. A. Barrio, H. Bartko, D. Bastieri, J. Becerra González, J. K. Becker, W. Bednarek, K. Berger, E. Bernardini, A. Biland, R. K. Bock, G. Bonnoli, P. Bordas, D. Borla Tridon, V. Bosch-Ramon, T. Bretz, I. Britvitch, M. Camara, E. Carmona, A. Chilingarian, S. Commichau, J. L. Contreras, J. Cortina, M. T. Costado, S. Covino, V. Curtef, F. Dazzi, A. De Angelis, E. De Cea del Pozo, R. de los Reyes, B. De Lotto, M. De Maria, F. De Sabata, C. Delgado Mendez, A. Dominguez, D. Dorner, M. Doro, D. Elsaesser, M. Errando, D. Ferenc, E. Fernández, R. Firpo, M. V. Fonseca, L. Font, N. Galante, R. J. García López, M. Garczarczyk, M. Gaug, F. Goebel, D. Hadasch, M. Hayashida, A. Herrero, D. Höhne-Mönch, J. Hose, C. C. Hsu, S. Huber, T. Jogler, D. Kranich, A. La Barbera, A. Laille, E. Leonardo, E. Lindfors, S. Lombardi, M. López, E. Lorenz, P. Majumdar, G. Maneva, N. Mankuzhiyil, K. Mannheim, L. Maraschi, M. Mariotti, M. Martínez, D. Mazin, M. Meucci, M. Meyer, J. M. Miranda, R. Mirzoyan, J. Moldón, M. Moles, A. Moralejo, D. Nieto, K. Nilsson, J. Ninkovic, I. Oya, R. Paoletti, J. M. Paredes, M. Pasanen, D. Pascoli, F. Pauss, R. G. Pegna, M. A. Perez-Torres, M. Persic, L. Peruzzo, F. Prada, E. Prandini, N. Puchades, A. Raymers, W. Rhode, M. Ribó, J. Rico, M. Rissi, A. Robert, S. Rügamer, A. Saggion, T. Y. Saito, M. Salvati, M. Sanchez-Conde, P. Sartori, K. Satalecka, V. Scalzotto, V. Scapin, T. Schweizer, M. Shayduk, K. Shinozaki, S. N. Shore, N. Sidro, A. Sierpowska-Bartosik, A. Sillanpää, J. Sitarek, D. Sobczynska, F. Spanier, A. Stamerra, L. S. Stark, L. Takalo, F. Tavecchio, P. Temnikov, D. Tescaro, M. Teshima, M. Tluczykont, D. F. Torres, N. Turini, H. Vankov, A. Venturini, V. Vitale, R. M. Wagner, W. Wittek, V. Zabalza, F. Zandanel, R. Zanin, J. Zapatero, V. Acciari, E. Aliu, T. Arlen, M. Beilicke, W. Benbow, S. M. Bradbury, J. H. Buckley, V. Bugaev, Y. Butt, K. Byrum, A. Cannon, A. Cesarini, Y. C. Chow, L. Ciupik, P. Cogan, P. Colin, W. Cui, M. K. Daniel, R. Dickherber, C. Duke, T. Ergin, S. J. Fegan, J. P. Finley, G. Finnegan, P. Fortin, A. Furniss, D. Gall, G. H. Gillanders, R. Guenette, G. Gyuk, J. Grube, D. Hanna, J. Holder, D. Horan, C. M. Hui, T. Brian Humensky, A. Imran, P. Kaaret, N. Karlsson, M. Kertzman, D. Kieda, J. Kildea, A. Konopelko, H. Krawczynski, F. Krennrich, M. J. Lang, S. LeBohec, G. Maier, A. McCann, M. McCutcheon, A. Milovanovic, P. Moriarty, T. Nagai, R. A. Ong, A. N. Otte, D. Pandel, J. S. Perkins, A. Pichel, M. Pohl, K. Ragan, L. C. Reyes, P. T. Reynolds, E. Roache, H. J. Rose, M. Schroedter, G. H. Sembroski, A. W. Smith, D. Steele, S. P. Swordy, M. Theiling, J. A. Toner, L. Valcarcel, A. Varlotta, S. P. Wakely, J. E. Ward, T. C. Weekes, A. Weinstein, D. A. Williams, S. Wissel, M. Wood, B. Zitzer, I., Donnarumma, V., Vittorini, S., Vercellone, E. D., Monte, M., Feroci, F., D'Ammando, L., Pacciani, A. W., Chen, M., Tavani, A., Bulgarelli, A., Giuliani, Longo, Francesco, G., Pucella, A., Argan, G., Barbiellini, F., Boffelli, P., Caraveo, P. W., Cattaneo, V., Cocco, E., Costa, G. D., Pari, G. D., Cocco, Y., Evangelista, M., Fiorini, T., Froysland, M., Frutti, F., Fuschino, M., Galli, F., Gianotti, C., Labanti, I., Lapshov, F., Lazzarotto, P., Lipari, M., Marisaldi, M., Mastropietro, S., Mereghetti, E., Morelli, A., Morselli, A., Pellizzoni, F., Perotti, P., Picozza, G., Porrovecchio, M., Prest, M., Rapisarda, A., Rappoldi, A., Rubini, P., Soffitta, M., Trifoglio, A., Troi, E., Vallazza, A., Zambra, D., Zanello, C., Pittori, P., Santolamazza, F., Verrecchia, P., Giommi, S., Colafrancesco, L., Salotti, M., Villata, C. M., Raiteri, W. P., Chen, N. V., Efimova, B., Jordan, T. S., Konstantinova, E., Koptelova, O. M., Kurtanidze, V. M., Larionov, J. A., Ro, A. C., Sadun, H., Anderhub, L. A., Antonelli, P., Antoranz, M., Backe, C., Baixera, S., Balestra, J. A., Barrio, H., Bartko, D., Bastieri, J. B., Gonzalez, J. K., Becker, W., Bednarek, K., Berger, E., Bernardini, A., Biland, R. K., Bock, G., Bonnoli, P., Borda, D. B., Tridon, V., Bosch Ramon, T., Bretz, I., Britvitch, M., Camara, E., Carmona, A., Chilingarian, S., Commichau, J. L., Contrera, J., Cortina, M. T., Costado, S., Covino, V., Curtef, F., Dazzi, A. D., Angeli, E. D., Del Pozo, R. D., Reye, B. D., Lotto, M. D., Maria, F. D., Sabata, C. D., Mendez, A., Dominguez, D., Dorner, M., Doro, D., Elsaesser, M., Errando, D., Ferenc, E., Fernandez, R., Firpo, M. V., Fonseca, L., Font, N., Galante, R. J. G., Lopez, M., Garczarczyk, M., Gaug, F., Goebel, D., Hadasch, M., Hayashida, A., Herrero, D., Hohne Monch, J., Hose, C. C., Hsu, S., Huber, T., Jogler, D., Kranich, A. L., Barbera, A., Laille, E., Leonardo, E., Lindfor, S., Lombardi, M., Lopez, E., Lorenz, P., Majumdar, G., Maneva, N., Mankuzhiyil, K., Mannheim, L., Maraschi, M., Mariotti, M., Martinez, D., Mazin, M., Meucci, M., Meyer, J. M., Miranda, R., Mirzoyan, J., Moldon, M., Mole, A., Moralejo, D., Nieto, K., Nilsson, J., Ninkovic, I., Oya, R., Paoletti, J. M., Parede, M., Pasanen, D., Pascoli, F., Pau, R. G., Pegna, M. A., Perez Torre, M., Persic, L., Peruzzo, F., Prada, E., Prandini, N., Puchade, A., Raymer, W., Rhode, M., Ribo, J., Rico, M., Rissi, A., Robert, S., Rugamer, A., Saggion, T. Y., Saito, M., Salvati, M., Sanchez Conde, P., Sartori, K., Satalecka, V., Scalzotto, V., Scapin, T., Schweizer, M., Shayduk, K., Shinozaki, S. N., Shore, N., Sidro, A., Sierpowska Bartosik, A., Sillanpaa, J., Sitarek, D., Sobczynska, F., Spanier, A., Stamerra, L. S., Stark, L., Takalo, F., Tavecchio, P., Temnikov, D., Tescaro, M., Teshima, M., Tluczykont, D. F., Torre, N., Turini, H., Vankov, A., Venturini, V., Vitale, R. M., Wagner, W., Wittek, V., Zabalza, F., Zandanel, R., Zanin, J., Zapatero, V., Acciari, E., Aliu, T., Arlen, M., Beilicke, W., Benbow, S. M., Bradbury, J. H., Buckley, V., Bugaev, Y., Butt, K., Byrum, A., Cannon, A., Cesarini, Y. C., Chow, L., Ciupik, P., Cogan, P., Colin, W., Cui, M. K., Daniel, R., Dickherber, C., Duke, T., Ergin, S. J., Fegan, J. P., Finley, G., Finnegan, P., Fortin, A., Furni, D., Gall, G. H., Gillander, R., Guenette, G., Gyuk, J., Grube, D., Hanna, J., Holder, D., Horan, C. M., Hui, T. B., Humensky, A., Imran, P., Kaaret, N., Karlsson, M., Kertzman, D., Kieda, J., Kildea, A., Konopelko, H., Krawczynski, F., Krennrich, M. J., Lang, S., Lebohec, G., Maier, A., Mccann, M., Mccutcheon, A., Milovanovic, P., Moriarty, T., Nagai, R. A., Ong, A. N., Otte, D., Pandel, J. S., Perkin, A., Pichel, M., Pohl, K., Ragan, L. C., Reye, P. T., Reynold, E., Roache, H. J., Rose, M., Schroedter, G. H., Sembroski, A. W., Smith, D., Steele, S. P., Swordy, M., Theiling, J. A., Toner, L., Valcarcel, A., Varlotta, S. P., Wakely, J. E., Ward, T. C., Weeke, A., Weinstein, D. A., William, S., Wissel, M., Wood, B., Zitzer, Donnarumma I, Vittorini V, Vercellone S, del Monte E, Feroci M, DAmmando F, Pacciani L, Chen A W, Tavani M, Bulgarelli A, Giuliani A, Longo F, Pucella G, Argan A, Barbiellini G, Boffelli F, Caraveo P, Cattaneo P W, Cocco V, Costa E, DeParis G, Di Cocco G, Evangelista Y, Fiorini M, Froysland T, Frutti M, Fuschino F, Galli M, Gianotti F, Labanti C, Lapshov I, Lazzarotto F, Lipari P, Marisaldi M, Mastropietro M, Mereghetti S, Morelli E, Morselli A, Pellizzoni A, Perotti F, Picozza P, Porrovecchio G, Prest M, Rapisarda M, Rappoldi A, Rubini A, Soffitta P, Trifoglio M, Trois A, Vallazza E, Zambra A, Zanello D, Pittori C, Santolamazza P, Verrecchia F, Giommi P, Colafrancesco S, Salotti L, Villata M, Raiteri C M, Chen W P, Efimova N V, Jordan B, Konstantinova T S, Koptelova E, Kurtanidze O M, Larionov V M, Ros J A, Sadun A C, Anderhub H, Antonelli L A, Antoranz P, Backes M, Baixeras C, Balestra S, Barrio J A, Bartko H, Bastieri D, González J Becerra, Becker J K, Bednarek W, Berger K, Bernardini E, Biland A, Bock R K, Bonnoli G, Bordas P, Tridon D Borla, Bosch-Ramon V, Bretz T, Britvitch I, Camara M, Carmona E, Chilingarian A, Commichau S, Contreras J L, Cortina J, Costado M T, Covino S, Curtef V, Dazzi F, DeAngelis A, DeCea del Pozo E, de los Reyes R, DeLotto B, DeMaria M, DeSabata F, Mendez C Delgado, Dominguez A, Dorner D, Doro M, Elsaesser D, Errando M, Ferenc D, Fernández E, Firpo R, Fonseca M V, Font L, Galante N, García López R J, Garczarczyk M, Gaug M, Goebel F, Hadasch D, Hayashida M, Herrero A, Höhne-Mönch D, Hose J, Hsu C C, Huber S, Jogler T, Kranich D, La Barbera A, Laille A, Leonardo E, Lindfors E, Lombardi S, López M, Lorenz E, Majumdar P, Maneva G, Mankuzhiyil N, Mannheim K, Maraschi L, Mariotti M, Martínez M, Mazin D, Meucci M, Meyer M, Miranda J M, Mirzoyan R, Moldón J, Moles M, Moralejo A, Nieto D, Nilsson K, Ninkovic J, Oya I, Paoletti R, Paredes J M, Pasanen M, Pascoli D, Pauss F, Pegna R G, Perez-Torres M A, Persic M, Peruzzo L, Prada F, Prandini E, Puchades N, Raymers A, Rhode W, Ribó M, Rico J, Rissi M, Robert A, Rügamer S, Saggion A, Saito T Y, Salvati M, Sanchez-Conde M, Sartori P, Satalecka K, Scalzotto V, Scapin V, Schweizer T, Shayduk M, Shinozaki K, Shore S N, Sidro N, Sierpowska-Bartosik A, Sillanpää A, Sitarek J, Sobczynska D, Spanier F, Stamerra A, Stark L S, Takalo L, Tavecchio F, Temnikov P, Tescaro D, Teshima M, Tluczykont M, Torres D F, Turini N, Vankov H, Venturini A, Vitale V, Wagner R M, Wittek W, Zabalza V, Zandanel F, Zanin R, Zapatero J, Acciari V, Aliu E, Arlen T, Beilicke M, Benbow W, Bradbury S M, Buckley J H, Bugaev V, Butt Y, Byrum K, Cannon A, Cesarini A, Chow Y C, Ciupik L, Cogan P, Colin P, Cui W, Daniel M K, Dickherber R, Duke C, Ergin T, Fegan S J, Finley J P, Finnegan G, Fortin P, Furniss A, Gall D, Gillanders G H, Guenette R, Gyuk G, Grube J, Hanna D, Holder J, Horan D, Hui C M, Humensky T Brian, Imran A, Kaaret P, Karlsson N, Kertzman M, Kieda D, Kildea J, Konopelko A, Krawczynski H, Krennrich F, Lang M J, LeBohec S, Maier G, McCann A, McCutcheon M, Milovanovic A, Moriarty P, Nagai T, Ong R A, Otte A N, Pandel D, Perkins J S, Pichel A, Pohl M, Ragan K, Reyes L C, Reynolds P T, Roache E, Rose H J, Schroedter M, Sembroski G H, Smith A W, Steele D, Swordy S P, Theiling M, Toner J A, Valcarcel L, Varlotta A, Wakely S P, Ward J E, Weekes T C, Weinstein A, Williams D A, Wissel S, Wood M, and Zitzer B
Subjects: campaign, Raigs còsmics, BL Lacertae: individual: Mrk421, galaxies: jets, X-Rays: Galaxies, gamma rays: observations, radiation mechanisms: nonthermal, bl-lacertae objects, blazars, Flux, Astrophysics, 01 natural sciences, 7. Clean energy, High Energy Gamma-ray Astronomy, law.invention, Raigs gamma, law, optical, MAGIC (telescope), Agile, blazr, X-ray, gamma, high energy observation, 010303 astronomy & astrophysics, webt, Physics, x-ray-spectra, Astrophysics (astro-ph), gamma-rays, lac objects, xmm-newton, Spectral energy distribution, Electrónica, Física nuclear, Raigs X, Electricidad, Flare, outburst, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, 0103 physical sciences, X-rays, BL Lacertae objects: individual (Mrk 421) – gamma rays: observations – galaxies: jets – radiation mechanisms: non-thermal – X-rays: galaxies, Blazar, Cosmic rays, 010308 nuclear & particles physics, Gamma rays, Astronomy and Astrophysics, Active Galactic Nuclei, radiation mechanisms: non-thermal, Light curve, Galaxies, Galàxies, MAGIC telescope, Space and Planetary Science, Very High Energy Gamma-ray Astronomy, ddc:520, AGILE satellite, bl lacertae objects: individual (mrk 421), Energy (signal processing), Lepton
Abstract: We present optical, X-ray, high energy ($\lessapprox 30$ GeV) and very high energy ($\gtrapprox 100$ GeV; VHE) observations of the high-frequency peaked blazar Mrk 421 taken between 2008 May 24 and June 23. A high energy $\gamma$-ray signal was detected by AGILE with \sqrt{TS}=4.5 on June 9--15, with $F(E>100 \mathrm{MeV})= 42^{+14}_{-12}\times 10^{-8}$ photons cm$^{-2}$ s$^{-1}$. This flaring state is brighter than the average flux observed by EGRET by a factor of $\sim$3, but still consistent with the highest EGRET flux. In hard X-rays (20-60 keV) SuperAGILE resolved a 5-day flare (June 9-15) peaking at $\sim$ 55 mCrab. SuperAGILE, RXTE/ASM and Swift/BAT data show a correlated flaring structure between soft and hard X-rays. Hints of the same flaring behavior are also detected in the simultaneous optical data provided by the GASP-WEBT. A Swift/XRT observation near the flaring maximum revealed the highest 2-10 keV flux ever observed from this source, of 2.6 $\times 10^{-9}$ erg cm$^{-2}$ s$^{-1}$ (i.e. > 100 mCrab). A peak synchrotron energy of $\sim$3 keV was derived, higher than typical values of $\sim$0.5-1 keV. VHE observations with MAGIC and VERITAS on June 6-8 show the flux peaking in a bright state, well correlated with the X-rays. This extraordinary set of simultaneous data, covering a twelve-decade spectral range, allowed for a deep analysis of the spectral energy distribution as well as of correlated light curves. The $\gamma$-ray flare can be interpreted within the framework of the synchrotron self-Compton model in terms of a rapid acceleration of leptons in the jet., Comment: accepted for publication in ApJL, 7 pages, 2 figures, 1 table
Published: 2009
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20. Discovery of Very High Energy Gamma Rays from PKS 1424+240 and Multiwavelength Constraints on its Redshift

Author: V.A. Acciari, E. Aliu, T. Arlen, T. Aune, M. Bautista, M. Beilicke, W. Benbow, M. Bottcher, D. Boltuch, S.M. Bradbury, J.H. Buckley, V. Bugaev, K. Byrum, A. Cannon, A. Cesarini, Y.C. Chow, L. Ciupik, P. Cogan, W. Cui, C. Duke, and A. Falcone
Published: 2012
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21. Constraints on Cosmic Rays, Magnetic Fields, and Dark Matter from Gamma-Ray Observations of the Coma Cluster of Galaxies with VERITAS and Fermi

Author: T. Arlen, T. Aune, M. Beilicke, W. Benbow, A. Bouvier, J. H. Buckley, V. Bugaev, K. Byrum, A. Cannon, A. Cesarini, L. Ciupik, E. Collins-Hughes, M. P. Connolly, W. Cui, R. Dickherber, J. Dumm, A. Falcone, S. Federici, Q. Feng, J. P. Finley, G. Finnegan, L. Fortson, A. Furniss, N. Galante, D. Gall, S. Godambe, S. Griffin, J. Grube, G. Gyuk, J. Holder, H. Huan, G. Hughes, T. B. Humensky, A. Imran, P. Kaaret, N. Karlsson, M. Kertzman, Y. Khassen, D. Kieda, H. Krawczynski, F. Krennrich, K. Lee, A. S Madhavan, G. Maier, P. Majumdar, S. McArthur, A. McCann, P. Moriarty, R. Mukherjee, T. Nelson, A. O’Faoláin de Bhróit, R. A. Ong, M. Orr, A. N. Otte, N. Park, J. S. Perkins, M. Pohl, H. Prokoph, J. Quinn, K. Ragan, L. C. Reyes, P. T. Reynolds, E. Roache, J. Ruppel, D. B. Saxon, M. Schroedter, G. H. Sembroski, C. Skole, A. W. Smith, I. Telezhinsky, G. Tešić, M. Theiling, S. Thibadeau, K. Tsurusaki, A. Varlotta, M. Vivier, S. P. Wakely, J. E. Ward, A. Weinstein, R. Welsing, D. A. Williams, B. Zitzer, C. Pfrommer, and A. Pinzke
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), Astrophysics::High Energy Astrophysical Phenomena, Dark matter, nonthermal emission, FOS: Physical sciences, Coma (optics), Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, galaxies: clusters: individual (coma (aco 1656)), magnetic fields, dark matter, large-scale structure, shock-waves, atmospheric cherenkov telescopes, diffuse radio-emission, cosmic rays, all-sky survey, Coma Cluster, upper limits, galactic-center, Galaxy cluster, Cherenkov radiation, gamma rays: galaxies: clusters, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Institut für Physik und Astronomie, Astronomy and Astrophysics, source catalog, Galaxy, x-ray, galaxies: clusters: general, Space and Planetary Science, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, Fermi Gamma-ray Space Telescope
Abstract: Observations of radio halos and relics in galaxy clusters indicate efficient electron acceleration. Protons should likewise be accelerated, suggesting that clusters may also be sources of very high-energy (VHE; E>100 GeV) gamma-ray emission. We report here on VHE gamma-ray observations of the Coma galaxy cluster with the VERITAS array of imaging Cherenkov telescopes, with complementing Fermi-LAT observations at GeV energies. No significant gamma-ray emission from the Coma cluster was detected. Integral flux upper limits at the 99% confidence level were measured to be on the order of (2-5)*10^-8\ ph. m^-2 s^-1 (VERITAS, >220 GeV} and ~2*10^-6 ph. m^-2 s^-1 (Fermi, 1-3 GeV), respectively. We use the gamma-ray upper limits to constrain CRs and magnetic fields in Coma. Using an analytical approach, the CR-to-thermal pressure ratio is constrained to be < 16% from VERITAS data and < 1.7% from Fermi data (averaged within the virial radius). These upper limits are starting to constrain the CR physics in self-consistent cosmological cluster simulations and cap the maximum CR acceleration efficiency at structure formation shocks to be, ApJ in press
Published: 2012
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22. Discovery of very high energy γ-ray emission from the snr g54.1+0.3

Author: A. McCann, R. A. Ong, Thomas Weisgarber, S. LeBohec, Gernot Maier, M. Beilicke, N. Karlsson, S. P. Wakely, Daniel Gall, S. M. Bradbury, G. Demet Senturk, D. Pandel, R. Dickherber, S. Thibadeau, T. B. Humensky, D. Boltuch, D. Steele, J. E. Ward, T. Aune, Geza Gyuk, B. Zitzer, S. McArthur, J. Grube, R. Guenette, L. Ciupik, V. A. Acciari, Jamie Holder, C. M. Hui, A. Furniss, E. Aliu, H. Krawczynski, G. H. Gillanders, F. Krennrich, S. Godambe, M. McCutcheon, A. Cesarini, P. Kaaret, S. P. Swordy, John L. Quinn, G. H. Sembroski, M. Bautista, R. Muhkerjee, K. Ragan, Y. Butt, G. Těsić, M. Theiling, A. Konopelko, Wystan Benbow, L. C. Reyes, M. Schroedter, Stephanie Wissel, S. Vincent, E. Roache, H. J. Rose, T. Arlen, Patrick Slane, J. H. Buckley, M. Kertzman, A. N. Otte, Matthew J.A. Wood, J. P. Finley, T. C. Weekes, M. J. Lang, Eric V. Gotthelf, David Kieda, A. Imran, David A. Williams, G. Finnegan, A. W. Smith, C. Duke, V. V. Vassiliev, P. Moriarty, Nicola Galante, D. S. Hanna, V. Bugaev, J. S. Perkins, Wei Cui, A. J.R. Weinstein, K. Byrum, P. T. Reynolds, Lucy Fortson, and Martin Pohl
Subjects: supernova remnant g54.1+0.3, catalog, Photon, Astrophysics::High Energy Astrophysical Phenomena, Flux, Astrophysics, pulsar wind nebulae, telescope, 01 natural sciences, g0.9+0.1, Luminosity, Pulsar, Observatory, veritas, 0103 physical sciences, crab-nebula, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, search, 010308 nuclear & particles physics, Resolution (electron density), Gamma ray, Astronomy and Astrophysics, gamma rays: general, pulsars: individual (j1930+1852, j1928+1746), astronomy, Crab Nebula, 13. Climate action, Space and Planetary Science, ism: supernova remnants, ddc:520, High Energy Physics::Experiment
Abstract: We report the discovery of very high energy (VHE) gamma-ray emission from the direction of the SNR G54.1+ 0.3 using the VERITAS ground-based gamma-ray observatory. The TeV signal has an overall significance of 6.8s and appears pointlike given the resolution of the instrument. The integral flux above 1 TeV is 2.5% of the Crab Nebula flux and significant emission is measured between 250 GeV and 4 TeV, well described by a power-law energy spectrum dN/dE similar to E(-Gamma) with a photon index Gamma = 2.39 +/- 0.23(stat) +/- 0.30sys. We find no evidence of time variability among observations spanning almost two years. Based on the location, the morphology, the measured spectrum, the lack of variability, and a comparison with similar systems previously detected in the TeV band, the most likely counterpart of this new VHE gamma-ray source is the pulsar wind nebula (PWN) in the SNR G54.1+0.3. The measured X-ray to VHE gamma-ray luminosity ratio is the lowest among all the nebulae supposedly driven by young rotation-powered pulsars, which could indicate a particle-dominated PWN.
Published: 2010
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23. Veritas upper limit on the very high energy emission from the radio galaxy NGC 1275

Author: V. A. Acciari, E. Aliu, T. Arlen, T. Aune, M. Bautista, M. Beilicke, W. Benbow, D. Boltuch, S. M. Bradbury, J. H. Buckley, V. Bugaev, K. Byrum, A. Cannon, O. Celik, A. Cesarini, L. Ciupik, P. Cogan, W. Cui, R. Dickherber, C. Duke, S. J. Fegan, J. P. Finley, P. Fortin, L. Fortson, A. Furniss, N. Galante, D. Gall, K. Gibbs, G. H. Gillanders, S. Godambe, J. Grube, R. Guenette, G. Gyuk, D. Hanna, J. Holder, D. Horan, C. M. Hui, T. B. Humensky, A. Imran, P. Kaaret, N. Karlsson, M. Kertzman, D. Kieda, A. Konopelko, H. Krawczynski, F. Krennrich, M. J. Lang, S. LeBohec, G. Maier, A. McCann, M. McCutcheon, J. Millis, P. Moriarty, R. Mukherjee, R. A. Ong, A. N. Otte, D. Pandel, J. S. Perkins, M. Pohl, J. Quinn, K. Ragan, P. T. Reynolds, E. Roache, H. J. Rose, M. Schroedter, G. H. Sembroski, A. W. Smith, D. Steele, S. P. Swordy, M. Theiling, J. A. Toner, A. Varlotta, V. V. Vassiliev, S. Vincent, R. G. Wagner, S. P. Wakely, J. E. Ward, T. C. Weekes, A. Weinstein, T. Weisgarber, D. A. Williams, S. Wissel, M. Wood, B. Zitzer, J. Kataoka, E. Cavazzuti, C. C. Cheung, B. Lott, D. J. Thompson, G. Tosti, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), and Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: jets, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Active galactic nucleus, Radio galaxy, Perseus A), Astrophysics::High Energy Astrophysical Phenomena, Flux, proton blazar, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, law.invention, galaxies: individual: NGC 1275 3C 84 Perseus A, Telescope, atmospheric cherenkov telescopes, Spitzer Space Telescope, law, 0103 physical sciences, 3C 84, Limit (mathematics), galaxies: Seyfert, gamma rays: observations, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, parameters, 010308 nuclear & particles physics, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], galaxies: individual (NGC 1275, Astronomy and Astrophysics, gamma-ray emission, galaxies: individual (ngc 1275, 3c 84, perseus a), radiation, Crab Nebula, Space and Planetary Science, markarian-501, active galactic nuclei, peaked bl-lacertae, discovery, Fermi Gamma-ray Space Telescope
Abstract: The recent detection by the Fermi gamma-ray space telescope of high-energy gamma-rays from the radio galaxy NGC 1275 makes the observation of the very high energy (VHE: E > 100 GeV) part of its broadband spectrum particularly interesting, especially for the understanding of active galactic nuclei (AGN) with misaligned multi-structured jets. The radio galaxy NGC 1275 was recently observed by VERITAS at energies above 100 GeV for about 8 hours. No VHE gamma-ray emission was detected by VERITAS from NGC 1275. A 99% confidence level upper limit of 2.1% of the Crab Nebula flux level is obtained at the decorrelation energy of approximately 340 GeV, corresponding to 19% of the power-law extrapolation of the Fermi Large Area Telescope (LAT) result.
Published: 2009
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24. Section on prospects for dark matter detection of the white paper on the status and future of ground-based TeV gamma-ray astronomy

Author: K. Byrum, D. Horan, T. Tait, R. Wanger, G. Zaharijas, J. Buckley, E. A. Baltz, G. Bertone, B. Dingus, S. Fegan, F. Ferrer, P. Gondolo, J. Hall, D. Hooper, S. Koushiappas, H. Krawczynksi, S. LeBohec, M. Pohl, S. Profumo, J Silk, V. Vassilev, M. Wood, S. Wakely, null FNAL, null Insti. d' Astrophysique, and null LANL
Subjects: Physics, White paper, WIMP, Astrophysics::High Energy Astrophysical Phenomena, Neutralino, Dark matter, Astronomy, Astrophysics::Cosmology and Extragalactic Astrophysics, Gamma-ray astronomy, Halo, Astrophysics, Gamma-ray burst, Galaxy
Abstract: This is a report on the findings of the dark matter science working group for the white paper on the status and future of TeV gamma-ray astronomy. The white paper was commissioned by the American Physical Society, and the full white paper can be found on astro-ph (arXiv:0810.0444). This detailed section discusses the prospects for dark matter detection with future gamma-ray experiments, and the complementarity of gamma-ray measurements with other indirect, direct or accelerator-based searches. We conclude that any comprehensive search for dark matter should include gamma-ray observations, both to identify the dark matter particle (through the characteristics of the gamma-ray spectrum) and to measure the distribution of dark matter in galactic halos.
Published: 2009
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25. Focal Plane Detectors for the Advanced Gamma-Ray Imaging System (AGIS)

Author: A. N. Otte, K. Byrum, G. Drake, A. Falcone, S. Funk, D. Horan, R. Mukherjee, A. Smith, H. Tajima, R. G. Wagner, D. A. Williams, Felix A. Aharonian, Werner Hofmann, and Frank Rieger
Subjects: Physics, Photomultiplier, Photon, Physics::Instrumentation and Detectors, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Gamma-ray astronomy, law.invention, Telescope, Optics, Silicon photomultiplier, Observatory, law, Angular resolution, business, Cherenkov radiation
Abstract: The Advanced Gamma‐Ray Imaging System (AGIS) is a concept for the next generation observatory in ground‐based very high energy gamma‐ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Simulations show that a substantial improvement in angular resolution may be achieved if the pixel diameter is reduced to the order of 0.05 deg, i.e. two to three times smaller than the pixel diameter of current Cherenkov telescope cameras. At these dimensions, photon detectors with smaller physical dimensions can be attractive alternatives to the classical photomultiplier tube (PMT). Furthermore, the operation of an experiment with the size of AGIS requires photon detectors that are among other things more reliable, more durable, and possibly higher efficiency photon detectors. Alternative photon detectors we are considering for AGIS include both silicon photomultipliers (SiPMs) and multi‐anode photomultipliers (MAPMTs). H...
Published: 2008
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26. A Topological Array Trigger for AGIS, the Advanced Gamma ray Imaging System

Author: F. Krennrich, J. Anderson, J. Buckley, K. Byrum, J. Dawson, G. Drake, W. Haberichter, A. Imran, H. Krawczynski, A. Kreps, M. Schroedter, A. Smith, Felix A. Aharonian, Werner Hofmann, and Frank Rieger
Subjects: Flexibility (engineering), Physics, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Gamma ray, Stereoscopy, Topology (electrical circuits), Image processing, Gamma-ray astronomy, Topology, law.invention, law, Cherenkov radiation, Energy (signal processing)
Abstract: Next generation ground based γ‐ray observatories such as AGIS1 and CTA2 are expected to cover a 1 km2 area with 50–100 imaging atmospheric Cherenkov telescopes. The stereoscopic view ol air showers using multiple view points raises the possibility to use a topological array trigger that adds substantial flexibility, new background suppression capabilities and a reduced energy threshold. In this paper we report on the concept and technical implementation of a fast topological trigger system, that makes use of real time image processing of individual camera patterns and their combination in a stereoscopic array analysis. A prototype system is currently under construction and we discuss the design and hardware of this topological array trigger system.
Published: 2008
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27. High Energy Physics Division semiannual report of research activities : July 1, 2004 - December 31, 2004

Author: J. Norem, J. Proudfoot, R. Stanek, D. K. Sinclair, J. Grudzinski, C. Zachos, Lawrence Nodulman, G. Drake, T. M. P. Tait, S. Magill, C. E. M. Wagner, J. Repond, J.L. Schlereth, E. L. Berger, C. Balazs, G. T. Bodwin, T. LeCompte, K. Byrum, M. C. Goodman, R. Wagner, W. Gai, D. S. Ayres, and R. Talaga
Subjects: Engineering, business.industry, law, Nuclear engineering, Particle accelerator, Division (mathematics), business, law.invention
Published: 2005
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28. High Energy Physics Division semiannual report of research activities, January 1, 2004 - June 30, 2004

Author: K. Byrum, C. Zachos, D. S. Ayres, P. Nadolsky, J. Repond, S. Magill, R. Talaga, G. Drake, W. Gai, J. Norem, J. Proudfoot, R. Stanek, D. K. Sinclair, R. Wagner, H. M. Spinka, E. L. Berger, M. C. Goodman, T. LeCompte, and Lawrence Nodulman
Subjects: Physics, law, Nuclear engineering, Particle accelerator, Division (mathematics), Engineering physics, Particle identification, law.invention
Published: 2005
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29. Self tagging studies using semileptonic B decays

Author: K. Byrum and A.B. Wicklund
Subjects: Semileptonic decay, Physics, Nuclear physics, Mass spectrum, B meson
Abstract: This report discusses the expectations and results of self tagging studies using semileptonic B decays.
Published: 1994
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30. P-2

Author: J. Esterly, D. Puttmann, and K. Byrum
Subjects: Pediatrics, medicine.medical_specialty, business.industry, Family medicine, Health care, Obstetrics and Gynecology, Medicine, business
Published: 1997
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31. The CDF forward muon system

Author: K. Byrum, T. Winch, M. Werner, D. Carlsmith, M.A. Thompson, J. Skarha, L. Pondrom, L. Markosky, M. Sheaff, A. Jaske, G. Ott, J. Rhoades, R. Handler, and D. Cline
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Muon, Toroid, Physics::Instrumentation and Detectors, Octant (solid geometry), Nuclear physics, Time-to-digital converter, Magnet, Scintillation counter, High Energy Physics::Experiment, Electronics, Instrumentation
Abstract: The general properties of the toroids, drift chambers and trigger counters in the CDF forward muon (FMU) system are discussed. The operation of the PSL time-to-digital converter and the UW HOPU (Half Octant Pattern Unit) module is also described. The forward muon level 1 trigger is presented.
Published: 1988
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32. A SEARCH FOR VERY HIGH ENERGY GAMMA RAYS FROM THE MISSING LINK BINARY PULSAR J1023+0038 WITH VERITAS.

Author: E. Aliu, S. Archambault, A. Archer, W. Benbow, R. Bird, J. Biteau, M. Buchovecky, J. H. Buckley, V. Bugaev, K. Byrum, J. V Cardenzana, M. Cerruti, X. Chen, L. Ciupik, M. P. Connolly, W. Cui, H. J. Dickinson, J. D. Eisch, A. Falcone, and Q. Feng
Subjects: GAMMA rays, PULSARS, RADIATION, MAGNETIC fields, WAVELENGTHS
Abstract: The binary millisecond radio pulsar PSR J1023+0038 exhibits many characteristics similar to the gamma-ray binary system PSR B1259–63/LS 2883, making it an ideal candidate for the study of high-energy nonthermal emission. It has been the subject of multiwavelength campaigns following the disappearance of the pulsed radio emission in 2013 June, which revealed the appearance of an accretion disk around the neutron star. We present the results of very high energy (VHE) gamma-ray observations carried out by the Very Energetic Radiation Imaging Telescope Array System before and after this change of state. Searches for steady and pulsed emission of both data sets yield no significant gamma-ray signal above 100 GeV, and upper limits are given for both a steady and pulsed gamma-ray flux. These upper limits are used to constrain the magnetic field strength in the shock region of the PSR J1023+0038 system. Assuming that VHE gamma rays are produced via an inverse Compton mechanism in the shock region, we constrain the shock magnetic field to be greater than ∼2 G before the disappearance of the radio pulsar and greater than ∼10 G afterward. [ABSTRACT FROM AUTHOR]
Published: 2016
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33. VERY HIGH ENERGY OBSERVATIONS OF THE BINARIES V 404 CYG AND 4U 0115+634 DURING GIANT X-RAY OUTBURSTS.

Author: A. Archer, W. Benbow, R. Bird, E. Bourbeau, M. Buchovecky, J. H. Buckley, V. Bugaev, K. Byrum, M. Cerruti, M. P. Connolly, W. Cui, M. Errando, A. Falcone, Q. Feng, M. Fernandez-Alonso, J. P. Finley, H. Fleischhack, A. Flinders, L. Fortson, and A. Furniss
Subjects: X-ray binaries, GAMMA ray bursts, FLUX (Energy), LUMINOSITY, ACTIVE galactic nuclei, BLACK holes
Abstract: Transient X-ray binaries produce major outbursts in which the X-ray flux can increase over the quiescent level by factors as large as 107. The low-mass X-ray binary V 404 Cyg and the high-mass system 4U 0115+634 underwent such major outbursts in 2015 June and October, respectively. We present here observations at energies above hundreds of GeV with the VERITAS observatory taken during some of the brightest X-ray activity ever observed from these systems. No gamma-ray emission has been detected by VERITAS in 2.5 hr of observations of the microquasar V 404 Cyg from 2015, June 20–21. The upper flux limits derived from these observations on the gamma-ray flux above 200 GeV of F cm−2 s−1 correspond to a tiny fraction (about 10−6) of the Eddington luminosity of the system, in stark contrast to that seen in the X-ray band. No gamma-rays have been detected during observations of 4U 0115+634 in the period of major X-ray activity in 2015 October. The flux upper limit derived from our observations is F cm−2 s−1 for gamma-rays above 300 GeV, setting an upper limit on the ratio of gamma-ray to X-ray luminosity of less than 4%. [ABSTRACT FROM AUTHOR]
Published: 2016
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34. UPPER LIMITS FROM FIVE YEARS OF BLAZAR OBSERVATIONS WITH THE VERITAS CHERENKOV TELESCOPES.

Author: S. Archambault, A. Archer, W. Benbow, R. Bird, J. Biteau, M. Buchovecky, J. H. Buckley, V. Bugaev, K. Byrum, M. Cerruti, X. Chen, L. Ciupik, M. P. Connolly, W. Cui, J. D. Eisch, M. Errando, A. Falcone, Q. Feng, J. P. Finley, and H. Fleischhack
Published: 2016
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35. TEV GAMMA-RAY OBSERVATIONS OF THE GALACTIC CENTER RIDGE BY VERITAS.

Author: A. Archer, W. Benbow, R. Bird, M. Buchovecky, J. H. Buckley, V. Bugaev, K. Byrum, J. V Cardenzana, M. Cerruti, X. Chen, L. Ciupik, E. Collins-Hughes, M. P. Connolly, J. D. Eisch, A. Falcone, Q. Feng, J. P. Finley, H. Fleischhack, A. Flinders, and L. Fortson
Subjects: GALACTIC center, GAMMA rays, GALACTIC nuclei, MILKY Way, SUPERNOVA remnants
Abstract: The Galactic Center ridge has been observed extensively in the past by both GeV and TeV gamma-ray instruments revealing a wealth of structure, including a diffuse component and the point sources G0.9+0.1 (a composite supernova remnant) and Sgr A* (believed to be associated with the supermassive black hole located at the center of our Galaxy). Previous very high energy (VHE) gamma-ray observations with the H.E.S.S. experiment have also detected an extended TeV gamma-ray component along the Galactic plane in the >300 GeV gamma-ray regime. Here we report on observations of the Galactic Center ridge from 2010 to 2014 by the VERITAS telescope array in the >2 TeV energy range. From these observations we (1) provide improved measurements of the differential energy spectrum for Sgr A* in the >2 TeV gamma-ray regime, (2) provide a detection in the >2 TeV gamma-ray emission from the composite SNR G0.9+0.1 and an improved determination of its multi-TeV gamma-ray energy spectrum, and (3) report on the detection of VER J1746-289, a localized enhancement of >2 TeV gamma-ray emission along the Galactic plane. [ABSTRACT FROM AUTHOR]
Published: 2016
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36. A SEARCH FOR BRIEF OPTICAL FLASHES ASSOCIATED WITH THE SETI TARGET KIC 8462852.

Author: A. U. Abeysekara, S. Archambault, A. Archer, W. Benbow, R. Bird, M. Buchovecky, J. H. Buckley, K. Byrum, J. V Cardenzana, M. Cerruti, X. Chen, J. L. Christiansen, L. Ciupik, W. Cui, H. J. Dickinson, J. D. Eisch, M. Errando, A. Falcone, D. J. Fegan, and Q. Feng
Published: 2016
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37. EXCEPTIONALLY BRIGHT TEV FLARES FROM THE BINARY LS I +61° 303.

Author: S. Archambault, A. Archer, T. Aune, A. Barnacka, W. Benbow, R. Bird, M. Buchovecky, J. H. Buckley, V. Bugaev, K. Byrum, J. V Cardenzana, M. Cerruti, X. Chen, L. Ciupik, E. Collins-Hughes, M. P. Connolly, W. Cui, H. J. Dickinson, J. Dumm, and J. D. Eisch
Published: 2016
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38. Fabrication of large dual-polarized multichroic TES bolometer arrays for CMB measurements with the SPT-3G camera.

Author: C M Posada, P A R Ade, Z Ahmed, K Arnold, J E Austermann, A N Bender, L E Bleem, B A Benson, K Byrum, J E Carlstrom, C L Chang, H M Cho, S T Ciocys, J F Cliche, T M Crawford, A Cukierman, D Czaplewski, J Ding, R Divan, and T de Haan
Subjects: FABRICATION (Manufacturing), COSMIC background radiation, POLARIZATION (Electricity), PARTICLE detectors, BOLOMETERS
Abstract: This work presents the procedures used at Argonne National Laboratory to fabricate large arrays of multichroic transition-edge sensor (TES) bolometers for cosmic microwave background (CMB) measurements. These detectors will be assembled into the focal plane for the SPT-3G camera, the third generation CMB camera to be installed in the South Pole Telescope. The complete SPT-3G camera will have approximately 2690 pixels, for a total of 16 140 TES bolometric detectors. Each pixel is comprised of a broad-band sinuous antenna coupled to a Nb microstrip line. In-line filters are used to define the different bands before the millimeter-wavelength signal is fed to the respective Ti/Au TES bolometers. There are six TES bolometer detectors per pixel, which allow for measurements of three band-passes (95, 150 and 220 GHz) and two polarizations. The steps involved in the monolithic fabrication of these detector arrays are presented here in detail. Patterns are defined using a combination of stepper and contact lithography. The misalignment between layers is kept below 200 nm. The overall fabrication involves a total of 16 processes, including reactive and magnetron sputtering, reactive ion etching, inductively coupled plasma etching and chemical etching. [ABSTRACT FROM AUTHOR]
Published: 2015
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39. Long-term TeV and X-ray Observations of the Gamma-ray Binary HESS J0632+057

Author: VERITAS Collaboration, Aliu, E., Archambault, S., Aune, T., Behera, B., Beilicke, M., Benbow, W., Berger, K., Bird, R., Bouvier, A., Buckley, J. H., Bugaev, V., Byrum, K., Cerruti, M., Chen, X., Ciupik, L., Connolly, M. P., Cui, W., Duke, C., Dumm, J., Errando, M., Falcone, A., Federici, S., Feng, Q., Finley, J. P., Fortin, P., Fortson, L., Furniss, A., Galante, N., Gillanders, G. H., Griffin, S., Griffiths, S. T., Grube, J., Gyuk, G., Hanna, D., Holder, J., Hughes, G., Humensky, T. B., Kaaret, P., Kertzman, M., Khassen, Y., Kieda, D., Krawczynski, H., Krennrich, F., Lang, M. J., Madhavan, A. S, Maier, G., Majumdar, P., McCann, A., Moriarty, P., Mukherjee, R., Nieto, D., de Bhr��ithe, A. O'Faol��in, Ong, R. A., Otte, A. N., Park, N., Perkins, J. S., Pohl, M., Popkow, A., Prokoph, H., Quinn, J., Ragan, K., Rajotte, J., Reyes, L. C., Reynolds, P. T., Richards, G. T., Roache, E., Rousselle, J., Sembroski, G. H., Sheidaei, F., Skole, C., Smith, A. W., Staszak, D., Stroh, M., Telezhinsky, I., Theiling, M., Tucci, J. V., Tyler, J., Varlotta, A., Vincent, S., Wakely, S. P., Weinstein, A., Welsing, R., Williams, D. A., Zajczyk, A., Zitzer, B., Collaboration, H. E. S. S., Abramowski, A., Aharonian, F., Benkhali, F. Ait, Akhperjanian, A. G., Ang��ner, E., Anton, G., Balenderan, S., Balzer, A., Barnacka, A., Becherini, Y., Tjus, J. Becker, Bernl��hr, K., Birsin, E., Bissaldi, E., Biteau, J., B��ttcher, M., Boisson, C., Bolmont, J., Bordas, P., Brucker, J., Brun, F., Brun, P., Bulik, T., Carrigan, S., Casanova, S., Chadwick, P. M., Chalme-Calvet, R., Chaves, R. C. G., Cheesebrough, A., Chr��tien, M., Colafrancesco, S., Cologna, G., Conrad, J., Couturier, C., Dalton, M., Daniel, M. K., Davids, I. D., Degrange, B., Deil, C., deWilt, P., Dickinson, H. J., Djannati-Ata��, A., Domainko, W., Drury, L. O'C., Dubus, G., Dutson, K., Dyks, J., Dyrda, M., Edwards, T., Egberts, K., Eger, P., Espigat, P., Farnier, C., Fegan, S., Feinstein, F., Fernandes, M. V., Fernandez, D., Fiasson, A., Fontaine, G., Forster, A., F��ling, M., Gajdus, M., Gallant, Y. A., Garrigoux, T., Giavitto, G., Giebels, B., Glicenstein, J. F., Grondin, M. -H., Grudzi��ska, M., H��ffner, S., Hahn, J., Harris, J., Heinzelmann, G., Henri, G., Hermann, G., Hervet, O., Hillert, A., Hinton, J. A., Hofmann, W., Hofverberg, P., Holler, M., Horns, D., Jacholkowska, A., Jahn, C., Jamrozy, M., Janiak, M., Jankowsky, F., Jung, I., Kastendieck, M. A., Katarzy��ski, K., Katz, U., Kaufmann, S., Kh��lifi, B., Kieffer, M., Klepser, S., Klochkov, D., Klu��niak, W., Kneiske, T., Kolitzus, D., Komin, Nu., Kosack, K., Krakau, S., Krayzel, F., Kr��ger, P. P., Laffon, H., Lamanna, G., Lefaucheur, J., Lemi��re, A., Lemoine-Goumard, M., Lenain, J. -P., Lennarz, D., Lohse, T., Lopatin, A., Lu, C. -C., Marandon, V., Marcowith, A., Marx, R., Maurin, G., Maxted, N., Mayer, M., McComb, T. J. L., M��hault, J., Menzler, U., Meyer, M., Moderski, R., Mohamed, M., Moulin, E., Murach, T., Naumann, C. L., de Naurois, M., Niemiec, J., Nolan, S. J., Oakes, L., Ohm, S., Wilhelmi, E. de On��a, Opitz, B., Ostrowski, M., Oya, I., Panter, M., Parsons, R. D., Arribas, M. Paz, Pekeur, N. W., Pelletier, G., Perez, J., Petrucci, P. -O., Peyaud, B., Pita, S., Poon, H., P��hlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Raue, M., Reimer, A., Reimer, O., Renaud, M., Reyes, R. de los, Rieger, F., Rob, L., Romoli, C., Rosier-Lees, S., Rowell, G., Rudak, B., Rulten, C. B., Sahakian, V., Sanchez, D. A., Santangelo, A., Schlickeiser, R., Sch��ssler, F., Schulz, A., Schwanke, U., Schwarzburg, S., Schwemmer, S., Sol, H., Spengler, G., Spies, F., Stawarz, ��., Steenkamp, R., Stegmann, C., Stinzing, F., Stycz, K., Sushch, I., Szostek, A., Tavernet, J. -P., Tavernier, T., Taylor, A. M., Terrier, R., Tluczykont, M., Trichard, C., Valerius, K., van Eldik, C., Vasileiadis, G., Venter, C., Viana, A., Vincent, P., V��lk, H. J., Volpe, F., Vorster, M., Wagner, S. J., Wagner, P., Ward, M., Weidinger, M., Weitzel, Q., White, R., Wierzcholska, A., Willmann, P., W��rnlein, A., Wouters, D., Zacharias, M., Zdziarski, A. A., Zech, A., Zechlin, H. -S., H.E.S.S. Collaboration, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Astroparticules (ASTRO), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), HESS, Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), 24420530 - Böttcher, Markus, 10103449 - Krüger, Petrus Paulus, 22050574 - Pekeur, Nicolette Whilna, 12006653 - Venter, Christo, 12792322 - Vorster, Michael Johannes, 23909196 - Casanova, Sabrina, 24922986 - Sushch, Iurii, E., Aliu, S., Archambault, T., Aune, B., Behera, M., Beilicke, W., Benbow, K., Berger, R., Bird, A., Bouvier, J. H., Buckley, V., Bugaev, K., Byrum, M., Cerruti, X., Chen, L., Ciupik, M. P., Connolly, W., Cui, C., Duke, J., Dumm, M., Errando, A., Falcone, S., Federici, Q., Feng, J. P., Finley, P., Fortin, L., Fortson, A., Furni, N., Galante, G. H., Gillander, S., Griffin, S. T., Griffith, J., Grube, G., Gyuk, D., Hanna, J., Holder, G., Hughe, T. B., Humensky, P., Kaaret, M., Kertzman, Y., Khassen, D., Kieda, H., Krawczynski, F., Krennrich, M. J., Lang, A. S., Madhavan, G., Maier, P., Majumdar, A., Mccann, P., Moriarty, R., Mukherjee, D., Nieto, A., O’Faoláin de Bhróithe, R. A., Ong, A. N., Otte, N., Park, J. S., Perkin, M., Pohl, A., Popkow, H., Prokoph, J., Quinn, K., Ragan, J., Rajotte, L. C., Reye, P. T., Reynold, G. T., Richard, E., Roache, J., Rousselle, G. H., Sembroski, F., Sheidaei, C., Skole, A. W., Smith, D., Staszak, M., Stroh, I., Telezhinsky, M., Theiling, J. V., Tucci, J., Tyler, A., Varlotta, S., Vincent, S. P., Wakely, A., Weinstein, R., Welsing, D. A., William, A., Zajczyk, B., Zitzer, A., Abramowski, F., Aharonian, F., Ait Benkhali, A. G., Akhperjanian, E., Angüner, G., Anton, S., Balenderan, A., Balzer, A., Barnacka, Y., Becherini, J., Becker Tju, K., Bernlöhr, E., Birsin, Bissaldi, Elisabetta, J., Biteau, M., Böttcher, C., Boisson, J., Bolmont, P., Borda, J., Brucker, F., Brun, P., Brun, T., Bulik, S., Carrigan, S., Casanova, P. M., Chadwick, R., Chalme Calvet, R. C. G., Chave, A., Cheesebrough, M., Chrétien, S., Colafrancesco, G., Cologna, J., Conrad, C., Couturier, M., Dalton, M. K., Daniel, I. D., David, B., Degrange, C., Deil, P., Dewilt, H. J., Dickinson, A., Djannati Ataï, W., Domainko, Drury, L. O. ’. C., G., Dubu, K., Dutson, J., Dyk, M., Dyrda, T., Edward, K., Egbert, P., Eger, P., Espigat, C., Farnier, S., Fegan, F., Feinstein, M. V., Fernande, D., Fernandez, A., Fiasson, G., Fontaine, A., Förster, M., Füssling, M., Gajdu, Y. A., Gallant, T., Garrigoux, G., Giavitto, B., Giebel, J. F., Glicenstein, M. H., Grondin, M., Grudzińska, S., Häffner, J., Hahn, J., Harri, G., Heinzelmann, G., Henri, G., Hermann, O., Hervet, A., Hillert, J. A., Hinton, W., Hofmann, P., Hofverberg, M., Holler, D., Horn, A., Jacholkowska, C., Jahn, M., Jamrozy, M., Janiak, F., Jankowsky, I., Jung, M. A., Kastendieck, K., Katarzyński, U., Katz, S., Kaufmann, B., Khélifi, M., Kieffer, S., Klepser, D., Klochkov, W., Kluźniak, T., Kneiske, D., Kolitzu, Komin, N. u., K., Kosack, S., Krakau, F., Krayzel, P. P., Krüger, H., Laffon, G., Lamanna, J., Lefaucheur, A., Lemière, M., Lemoine Goumard, J. P., Lenain, D., Lennarz, T., Lohse, A., Lopatin, C. C., Lu, V., Marandon, A., Marcowith, R., Marx, G., Maurin, N., Maxted, M., Mayer, T. J. L., Mccomb, J., Méhault, U., Menzler, M., Meyer, R., Moderski, M., Mohamed, E., Moulin, T., Murach, C. L., Naumann, M., de Nauroi, J., Niemiec, S. J., Nolan, L., Oake, S., Ohm, E., de Oña Wilhelmi, B., Opitz, M., Ostrowski, I., Oya, M., Panter, R. D., Parson, M., Paz Arriba, N. W., Pekeur, G., Pelletier, J., Perez, P. O., Petrucci, B., Peyaud, S., Pita, H., Poon, G., Pühlhofer, M., Punch, A., Quirrenbach, S., Raab, M., Raue, A., Reimer, O., Reimer, M., Renaud, R., de los Reye, F., Rieger, L., Rob, C., Romoli, S., Rosier Lee, G., Rowell, B., Rudak, C. B., Rulten, V., Sahakian, D. A., Sanchez, A., Santangelo, R., Schlickeiser, F., Schüssler, A., Schulz, U., Schwanke, S., Schwarzburg, S., Schwemmer, H., Sol, G., Spengler, F., Spie, Ł., Stawarz, R., Steenkamp, C., Stegmann, F., Stinzing, K., Stycz, I., Sushch, A., Szostek, J. P., Tavernet, T., Tavernier, A. M., Taylor, R., Terrier, M., Tluczykont, C., Trichard, K., Valeriu, C., van Eldik, G., Vasileiadi, C., Venter, A., Viana, P., Vincent, H. J., Völk, F., Volpe, M., Vorster, S. J., Wagner, P., Wagner, M., Ward, M., Weidinger, Q., Weitzel, R., White, A., Wierzcholska, P., Willmann, A., Wörnlein, D., Wouter, M., Zacharia, A. A., Zdziarski, A., Zech, and H. S., Zechlin
Subjects: catalog, general(HESS J0632+057, VER J0633+057) [gamma rays], Acceleration of particles, binaries:general, Astrophysics, telescope, 01 natural sciences, general [binaries], ls-i +61-degrees-303, emission, i+61 303, 010303 astronomy & astrophysics, HESS - Abteilung Hofmann, acceleration of particle, media_common, acceleration of particles, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), WR star binaries, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Gamma ray, general. [Gamma rays], Orbital period, veritas observations, winds, Orbit, binaries: general, i+61-degrees-303, Astrophysics - High Energy Astrophysical Phenomena, general (HESS J0632+057, VER J0633+057) [gamma rays], [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Hochenergie-Astrophysik Theorie - Abteilung Hofmann, FOS: Physical sciences, Context (language use), Ephemeris, gamma rays: general, 0103 physical sciences, WR star binarie, Cherenkov radiation, 010308 nuclear & particles physics, variability, Institut für Physik und Astronomie, Astronomy and Astrophysics, Light curve, Space and Planetary Science, Sky, ddc:520, general [gamma rays], gamma rays: general(hess j0632+057, ver j0633+057), discovery
Abstract: HESS J0632+057 is the only gamma-ray binary known so far whose position in the sky allows observations with ground-based observatories both in the northern and southern hemispheres. Here we report on long-term observations of HESS J0632+057 conducted with the VERITAS and H.E.S.S. Cherenkov Telescopes and the X-ray Satellite Swift, spanning a time range from 2004 to 2012 and covering most of the system's orbit. The VHE emission is found to be variable, and is correlated with that at X-ray energies. An orbital period of $315 ^{+6}_{-4}$ days is derived from the X-ray data set, which is compatible with previous results, $P = (321 \pm 5$) days. The VHE light curve shows a distinct maximum at orbital phases close to 0.3, or about 100 days after periastron passage, which coincides with the periodic enhancement of the X-ray emission. Furthermore, the analysis of the TeV data shows for the first time a statistically significant ($> 6.5 \sigma$) detection at orbital phases 0.6--0.9. The obtained gamma-ray and X-ray light curves and the correlation of the source emission at these two energy bands are discussed in the context of the recent ephemeris obtained for the system. Our results are compared to those reported for other gamma-ray binaries., Comment: 35 pages, 8 figures, accepted for publication in ApJ
Published: 2014
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40. Introducing the CTA concept

Author: A. Mathieu, R. G. Wagner, K. Panagiotidis, S Rosier Lees, Julien Rousselle, M. Gómez Berisso, Michela Uslenghi, Stephen Maxfield, R. C. Shellard, Ivica Puljak, T. Le Flour, Thomas Schanz, Tobias C. Walther, Juanan Aguilar, Pierre Colin, M. Chikawa, N. Fouque, Mosè Mariotti, G. Fontaine, Merja Tornikoski, V. Diez-Blanco, Enrico Giro, A. Krepps, G. Koss, J. M. Martin, Sergio Billotta, E. de Oña Wilhelmi, Keitaro Takahashi, S. Buson, P. Brook, S. Steiner, M. Dyrda, Joseph Silk, Sera Markoff, P. Lubinski, U. Schwanke, Sauvik Bhattacharyya, J. Ripken, T. Haubold, C. Zurbach, H. Wetteskind, R. Hermel, J. Darling, J. Nicolau-Kukliński, Konstancja Satalecka, M. Videla, Stefan Funk, P. Conconi, S. Bajtlik, Lukasz Stawarz, J. M. Paredes, K. Reitberger, Stefan Wagner, Teresa Mineo, David Kieda, G. Pareschi, Shigeto Kabuki, Makoto Sawada, Antonio Stamerra, Rodolfo Canestrari, N. Baby, G. Crimi, P. Kostka, J. Grube, R. Zanin, I. K. Kominis, L. Mc Comb, R. Sternberger, M. Fesquet, M. Tokarz, David Fink, Daniela Dorner, N. Hamer Heras, A. Moralejo Olaizola, M. de Naurois, Diego F. Torres, Claes Fransson, K. Nishijima, Yutaka Fujita, L. Fresnillo, B. García, R. Kossakowski, A. Masserot, H. von Gunten, Alkiviadis F. Bais, Ciro Bigongiari, A. Saggion, G. Papyan, I. Mrusek, K. Farakos, J. Michałowski, A. Franckowiak, Fernando Martinez, M. Doert, R. Wawrzaszek, Michele Doro, L. Sapozhnikov, Claudia Lavalley, D. Thuermann, A.A. Zdziarski, Cristina Knapic, Karen Byrum, N. Neyroud, Petr Schovanek, W. Domainko, D. Kastana, E. Birsin, Adrian Biland, F. Sánchez, Alexandre Marcowith, M. Errando, R. L. C. Starling, J. Schultze, A. Weinstein, B. B. Singh, Yassir Moudden, Jelena Aleksić, C. L. Naumann, V. Waegebaert, M. Shayduk, U. F. Katz, Gianpiero Tagliaferri, M. Schroedter, A. Vollhardt, O. Reimann, Hideyuki Ohoka, Vincenzo Testa, C. Jablonski, Tsuguya Naito, J. Schäfer, Stavros Maltezos, A. Wierzcholska, P. Wawer, L. Nellen, F. Mirabel, Tatsuo Yoshida, P. H. Carton, Nina Nowak, L. Platos, Riccardo Rando, P. P. Krueger, R. Wischnewski, W. Romaszkan, E. Fede, Martino Marisaldi, Markus Gaug, Richard Willingale, J. H. Buckley, U. De AlmeidaBarres, J. Knapp, Saverio Lombardi, D. della Volpe, A. Herrero, A. Bottani, E. Delagnes, Martin J. Hardcastle, C. Morello, Anna Lipniacka, T. Greenshaw, M. Renaud, Giancarlo Cusumano, Jonathan Biteau, M. Sowiński, J. R. T. de Mello Neto, T. B. Humensky, Michael G. Richer, G. Parks, G. Grasseau, H. Baba, Gino Tosti, Damir Lelas, H. Krawzcynski, David Paneque, M. Barcelo, R. Dickherber, P. Ferrando, Shinji Hara, D. Florin, Hideaki Katagiri, T. Shibata, Fuyuki Tokanai, N. A. McCubbin, J. Gomez-Ortega, D. Nakajima, A. Liolios, P. Laporte, Orjan Dale, A. Sillanpää, Dainis Dravins, Timothée Grégoire, Nu. Komin, A. Mihailidis, L. Sidoli, Shiu-Hang Lee, A. W. Chen, J. M. Illa, A. Kuznetsov, P. Munar-Adrover, D. Dominis Prester, Marcos Daniel Actis, Abraham D. Falcone, L. Journet, D. Hadasch, N. Galante, A. Murphy, C. J. Todero Peixoto, S. Wiesand, A. Aravantinos, A. C. Rovero, J. L. Dournaux, P. Romano, M. Hrabovsky, R. de los Reyes Lopez, M. Ostrowski, J. Pallota, Geza Gyuk, Petar Temnikov, R. Dubois, Jan Ebr, R. Koul, David J. Smith, S. Schwarzburg, P. Manigot, Chad Finley, Tarek M. Hassan, Giuseppe Sottile, Evgeni Ovcharov, P. J. Rajda, F. Krennrich, Peter L. Moore, W. B. Focke, W. Bednarek, Elena Amato, Kazunori Kohri, J. Gamez-Garcia, I. Oya, A. Shibuya, German Hermann, William H. Lee, Dorota Sobczyńska, X. Zhou, C. Balkowski, G. Vallejo, M. Hayashida, M. Bitossi, Loukas Vlahos, H. Lockart, N. Geffroy, L. Tibaldo, Marek Jamrozy, Luke O'c. Drury, Pratik Majumdar, P. Sutcliffe, S. Schlenstedt, M. Palatka, Christophe Champion, H. Ueno, M. Rupiński, P. Giommi, J. Schwarz, G. Pühlhofer, Takashi Saito, W. van Driel, C. van Eldik, Q. Xiong, Yasuo Fukui, A. Donat, A. Ibarra, R. S. Warwick, Michiko Ohishi, A. W. Smith, J.-P. 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Jogler, Seth Digel, Claudio Vuerli, Hiromitsu Takahashi, Thomas Lohse, K. Saito, A. W. Borgland, Elisa Prandini, Helene Sol, Ryan Heller, M. Bogdan, D. Dumas, M. Stodulski, Y. Awane, Piercarlo Bonifacio, Pedro L. Luque-Escamilla, Judith H. Croston, Fabio Pizzolato, P. M. Chadwick, M. K. Daniel, Riccardo Paoletti, Reiko Orito, Katsuaki Asano, R. Frei, G. Disset, Valerie Connaughton, Juhani Huovelin, Hiroyasu Tajima, S. Vercellone, F. Feinstein, G. Decerprit, Riccardo Smareglia, S. Spyrou, Gustavo E. Romero, J. Shi, J. Carr, N. Girard, Dirk L. Hoffmann, Andreas Zech, Markus Boettcher, Osvaldo Catalano, Akira Okumura, M. Dohmke, C. Föhr, Sabrina Casanova, R. A. Cameron, Jan Conrad, K. Umehara, K. K. Yadav, A. Paizis, John L. Quinn, L. Pogosyan, C. Farnier, William J. Potter, Domenico Impiombato, Tadashi Kifune, Jonathan Granot, Gernot Maier, M. Cieślar, S. Palanque, G.W. Fraser, J. Prast, R. Bose, Heidi Sandaker, G. Lamanna, Dusan Mandat, J.F. Glicenstein, J. Harris, D. Naumann, J. 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K., Yadav, H., Yamamoto, T., Yamamoto, R., Yamazaki, S., Yanagita, J. M., Yebra, D., Yelo, A., Yoshida, T., Yoshida, T., Yoshikoshi, V., Zabalza, M., Zacharia, A., Zajczyk, R., Zanin, A., Zdziarski, A., Zech, A., Zhao, X., Zhou, K., Zietara, J., Ziolkowski, P., Ziolkowski, V., Zitelli, C., Zurbach, P., Zychowski, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), APC - Astrophysique des Hautes Energies (APC - AHE), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CTA, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Laboratoire d'Annecy de Physique des Particules (LAPP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), and High Energy Astrophys. & Astropart. Phys (API, FNWI)
Subjects: Next generation Cherenkov telescopes, Ciencias Físicas, 01 natural sciences, 7. Clean energy, TeV GAMMA-RAY ASTRONOMY, Observatory, Air showers, HESS, Cherenkov Telescopes, 010303 astronomy & astrophysics, MISSION, SUPERNOVA REMNANT W44, TELESCOPE, ASTRONOMY, EMISSION, Physics, ta213, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Settore FIS/01 - Fisica Sperimentale, Astrophysics::Instrumentation and Methods for Astrophysics, TeV gamma-ray astronomy, ddc:540, CIENCIAS NATURALES Y EXACTAS, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Air shower, AIR SHOWERS, Astrophysics::High Energy Astrophysical Phenomena, 0103 physical sciences, Preparatory phase, ta115, TeV gamma-ray astronomy Air showers Cherenkov Telescopes, 010308 nuclear & particles physics, business.industry, CHERENKOV TELESCOPES, Física, Astronomy, Institut für Physik und Astronomie, Astronomy and Astrophysics, ASTROFÍSICA, Cherenkov Telescope Array, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astronomía, Design study, Telecommunications, business
Abstract: The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project., La lista completa de autores puede consultarse en el documento o en la página web de la revista., Facultad de Ingeniería
Published: 2013
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41. Radio imaging of the very-high-energy gamma-ray emission region in the central engine of a radio galaxy

Author: Veritas, Collaboration, Monitoring Team, Vlba Ghz M., Collaboration, H. E. S. S., Magic, Collaboration, Acciari, V. A., Aliu, E., Arlen, T., Bautista, M., Beilicke, M., Benbow, W., Bradbury, S. M., Buckley, J. H., Bugaev, V., Butt, Y., Byrum, K., Cannon, A., Celik, O., Cesarini, A., Chow, Y. C., Ciupik, L., Cogan, P., Cui, W., Dickherber, R., Fegan, S. J., Finley, J. P., Fortin, P., Fortson, L., Furniss, A., Gall, D., Gillanders, G. H., Grube, J., Guenette, R., Gyuk, G., Hanna, D., Holder, J., Horan, D., Hui, C. M., Humensky, T. B., Imran, A., Kaaret, P., Karlsson, N., Kieda, D., Kildea, J., Konopelko, A., Krawczynski, H., Krennrich, F., Lang, M. J., Lebohec, S., Maier, G., Mccann, A., Mccutcheon, M., Millis, J., Moriarty, P., Ong, R. A., Otte, A. N., Pandel, D., Perkins, J. S., Petry, D., Pohl, M., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Roache, E., Rose, H. J., Schroedter, M., Sembroski, G. H., Smith, A. W., Swordy, S. P., Theiling, M., Toner, J. A., Varlotta, A., Vincent, S., Wakely, S. P., Ward, J. E., Weekes, T. C., Weinstein, A., Williams, D. A., Wissel, S., Wood, M., Walker, R. C., Davies, F., Hardee, P. E., Junor, W., Ly, C., Aharonian, F., Akhperjanian, A. G., Anton, G., Barres Almeida, U., Bazer-Bachi, A. R., Becherini, Y., Behera, B., Bernlohr, K., Bochow, A., Boisson, C., Bolmont, J., Borrel, V., Brucker, J., Brun, F., Brun, P., Buhler, R., Bulik, T., Busching, I., Boutelier, T., Chadwick, P. M., Charbonnier, A., Chaves, R. C. G., Cheesebrough, A., Chounet, L-M, Clapson, A. C., Coignet, G., Dalton, M., Daniel, M. K., Davids, I. D., Degrange, B., Deil, C., Dickinson, H. J., Djannati-Atai, A., Domainko, W., Drury, L. O. C., Dubois, F., Dubus, G., Dyks, J., Dyrda, M., Egberts, K., Emmanoulopoulos, D., Espigat, P., Farnier, C., Feinstein, F., Fiasson, A., Forster, A., Fontaine, G., Fussling, M., Gabici, S., Gallant, Y. A., Gerard, L., Gerbig, D., Giebels, B., Glicenstein, J. F., Gluck, B., Goret, P., Gohring, D., Hauser, D., Hauser, M., Heinz, S., Heinzelmann, G., Henri, G., Hermann, G., Hinton, J. A., Hoffmann, A., Hofmann, W., Holleran, M., Hoppe, S., Horns, D., Jacholkowska, A., Jager, O. C., Jahn, C., Jung, I., Katarzynski, K., Katz, U., Kaufmann, S., Kendziorra, E., Kerschhaggl, M., Khangulyan, D., Khelifi, B., Keogh, D., Kluzniak, W., Kneiske, T., Komin, Nu, Kosack, K., Lamanna, G., Lenain, J-P, Lohse, T., Marandon, V., Martin, J. M., Martineau-Huynh, O., Marcowith, A., Maurin, D., Mccomb, T. J. L., Medina, M. C., Moderski, R., Moulin, E., Naumann-Godo, M., Naurois, M., Nedbal, D., Nekrassov, D., Nicholas, B., Niemiec, J., Nolan, S. J., Ohm, S., Olive, J-F, Ona Wilhelmi, E., Orford, K. J., Ostrowski, M., Panter, M., Paz Arribas, M., Pedaletti, G., Pelletier, G., Petrucci, P-O, Pita, S., Puhlhofer, G., Punch, M., Quirrenbach, A., Raubenheimer, B. C., Raue, M., Rayner, S. M., Renaud, M., Rieger, F., Ripken, J., Rob, L., Rosier-Lees, S., Rowell, G., Rudak, B., Rulten, C. B., Ruppel, J., Sahakian, V., Santangelo, A., Schlickeiser, R., Schock, F. M., Schroder, R., Schwanke, U., Schwarzburg, S., Schwemmer, S., Shalchi, A., Sikora, M., Skilton, J. L., Sol, H., Spangler, D., Stawarz, L., Steenkamp, R., Stegmann, C., Stinzing, F., Superina, G., Szostek, A., Tam, P. H., Tavernet, J-P, Terrier, R., Tibolla, O., Tluczykont, M., Christopher van Eldik, Vasileiadis, G., Venter, C., Venter, L., Vialle, J. P., Vincent, P., Vivier, M., Volk, H. J., Volpe, F., Wagner, S. J., Ward, M., Zdziarski, A. A., Zech, A., Anderhub, H., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Balestra, S., Barrio, J. A., Bastieri, D., Becerra Gonzalez, J., Becker, J. K., Bednarek, W., Berger, K., Bernardini, E., Biland, A., Bock, R. K., Bonnoli, G., Bordas, P., Borla Tridon, D., Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britvitch, I., Camara, M., Carmona, E., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Curtef, V., Dazzi, F., Angelis, A., Cea Del Pozo, E., Delgado Mendez, C., Los Reyes, R., Lotto, B., Maria, M., Sabata, F., Dominguez, A., Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fernandez, E., Firpo, R., Fonseca, M. V., Font, L., Galante, N., Garcia Lopez, R. J., Garczarczyk, M., Gaug, M., Goebel, F., Hadasch, D., Hayashida, M., Herrero, A., Hildebrand, D., Hohne-Monch, D., Hose, J., Hsu, C. C., Jogler, T., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldon, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Oya, I., Paoletti, R., Paredes, J. M., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Reichardt, I., Rhode, W., Ribo, M., Rico, J., Rissi, M., Robert, A., Rugamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sanchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schweizer, T., Shayduk, M., Shore, S. N., Sidro, N., Sierpowska-Bartosik, A., Sillanpaa, A., Sitarek, J., Sobczynska, D., Spanier, F., Stamerra, A., Stark, L. S., Takalo, L., Tavecchio, F., Temnikov, P., Tescaro, D., Teshima, M., Torres, D. F., Turini, N., Vankov, H., Wagner, R. M., Zabalza, V., Zandanel, F., Zanin, R., Zapatero, J., Centre d'étude spatiale des rayonnements (CESR), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), HESS, Universitat de Barcelona, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)-AstroParticule et Cosmologie (APC (UMR_7164)), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), V. A., Acciari, E., Aliu, T., Arlen, M., Bautista, M., Beilicke, W., Benbow, S. M., Bradbury, J. H., Buckley, V., Bugaev, Y., Butt, K., Byrum, A., Cannon, O., Celik, A., Cesarini, Y. C., Chow, L., Ciupik, P., Cogan, W., Cui, R., Dickherber, S. J., Fegan, J. P., Finley, P., Fortin, L., Fortson, A., Furni, D., Gall, G. H., Gillander, J., Grube, R., Guenette, G., Gyuk, D., Hanna, J., Holder, D., Horan, C. M., Hui, T. B., Humensky, A., Imran, P., Kaaret, N., Karlsson, D., Kieda, J., Kildea, A., Konopelko, H., Krawczynski, F., Krennrich, M. J., Lang, S., Lebohec, G., Maier, A., Mccann, M., Mccutcheon, J., Milli, P., Moriarty, R. A., Ong, A. N., Otte, D., Pandel, J. S., Perkin, D., Petry, M., Pohl, J., Quinn, K., Ragan, L. C., Reye, P. T., Reynold, E., Roache, H. J., Rose, M., Schroedter, G. H., Sembroski, A. W., Smith, S. P., Swordy, M., Theiling, J. A., Toner, A., Varlotta, S., Vincent, S. P., Wakely, J. E., Ward, T. C., Weeke, A., Weinstein, D. A., William, S., Wissel, M., Wood, R. C., Walker, F., Davie, P. E., Hardee, W., Junor, C., Ly, F., Aharonian, A. G., Akhperjanian, G., Anton, U. B., de Almeida, A. R., Bazer Bachi, Y., Becherini, B., Behera, K., Bernlohr, A., Bochow, C., Boisson, J., Bolmont, V., Borrel, J., Brucker, F., Brun, P., Brun, R., Buhler, T., Bulik, I., Busching, T., Boutelier, P. M., Chadwick, A., Charbonnier, R. C. G., Chave, A., Cheesebrough, L. M., Chounet, A. C., Clapson, G., Coignet, M., Dalton, M. K., Daniel, I. D., David, B., Degrange, C., Deil, H. J., Dickinson, A., Djannati Atai, W., Domainko, L. O., Drury, F., Duboi, G., Dubu, J., Dyk, M., Dyrda, K., Egbert, D., Emmanoulopoulo, P., Espigat, C., Farnier, F., Feinstein, A., Fiasson, A., Forster, G., Fontaine, M., Fussling, S., Gabici, Y. A., Gallant, L., Gerard, D., Gerbig, B., Giebel, J. F., Glicenstein, B., Gluck, P., Goret, D., Gohring, D., Hauser, M., Hauser, S., Heinz, G., Heinzelmann, G., Henri, G., Hermann, J. A., Hinton, A., Hoffmann, W., Hofmann, M., Holleran, S., Hoppe, D., Horn, A., Jacholkowska, O. C., de Jager, C., Jahn, I., Jung, K., Katarzynski, U., Katz, S., Kaufmann, E., Kendziorra, M., Kerschhaggl, D., Khangulyan, B., Khelifi, D., Keogh, W., Kluzniak, T., Kneiske, N., Komin, K., Kosack, G., Lamanna, J. P., Lenain, T., Lohse, V., Marandon, J. M., Martin, O., Martineau Huynh, A., Marcowith, D., Maurin, T. J. L., Mccomb, M. C., Medina, R., Moderski, E., Moulin, M., Naumann Godo, M. d., Nauroi, D., Nedbal, D., Nekrassov, B., Nichola, J., Niemiec, S. J., Nolan, S., Ohm, J. F., Olive, E. D., Wilhelmi, K. J., Orford, M., Ostrowski, M., Panter, M. P., Arriba, G., Pedaletti, G., Pelletier, P. O., Petrucci, S., Pita, M., Raue, S. M., Rayner, M., Renaud, F., Rieger, J., Ripken, L., Rob, S., Rosier Lee, G., Rowell, B., Rudak, C. B., Rulten, J., Ruppel, V., Sahakian, A., Santangelo, R., Schlickeiser, F. M., Schock, R., Schroder, U., Schwanke, S., Schwarzburg, S., Schwemmer, A., Shalchi, M., Sikora, J. L., Skilton, H., Sol, D., Spangler, L., Stawarz, R., Steenkamp, C., Stegmann, F., Stinzing, G., Superina, A., Szostek, P. H., Tam, J. P., Tavernet, R., Terrier, O., Tibolla, M., Tluczykont, C. v., Eldik, G., Vasileiadi, C., Venter, L., Venter, J. P., Vialle, P., Vincent, M., Vivier, H. J., Volk, F., Volpe, S. J., Wagner, M., Ward, A. A., Zdziarski, A., Zech, H., Anderhub, L. A., Antonelli, P., Antoranz, M., Backe, C., Baixera, S., Balestra, J. A., Barrio, D., Bastieri, J. B., Gonzlez, J. K., Becker, W., Bednarek, K., Berger, E., Bernardini, A., Biland, R. K., Bock, G., Bonnoli, P., Borda, D. B., Tridon, V., Bosch Ramon, D., Bose, I., Braun, T., Bretz, I., Britvitch, M., Camara, E., Carmona, S., Commichau, J. L., Contrera, J., Cortina, M. T., Costado, S., Covino, V., Curtef, F., Dazzi, A. D., Angeli, E. D., Del Pozo, C. D., Mendez, R. D., los Reye, B. D., Lotto, M. D., Maria, F. D., Sabata, A., Dominguez, D., Dorner, M., Doro, D., Elsaesser, M., Errando, D., Ferenc, E., Fernndez, R., Firpo, M. V., Fonseca, L., Font, N., Galante, R. J. G., Lopez, M., Garczarczyk, M., Gaug, F., Goebel, D., Hadasch, M., Hayashida, A., Herrero, D., Hildebrand, D., Hohne Monch, J., Hose, C. C., Hsu, T., Jogler, D., Kranich, A. L., Barbera, A., Laille, E., Leonardo, E., Lindfor, S., Lombardi, Longo, Francesco, M., Lopez, E., Lorenz, P., Majumdar, G., Maneva, N., Mankuzhiyil, K., Mannheim, L., Maraschi, M., Mariotti, M., Martinez, D., Mazin, M., Meucci, J. M., Miranda, R., Mirzoyan, H., Miyamoto, J., Moldon, M., Mole, A., Moralejo, D., Nieto, K., Nilsson, J., Ninkovic, I., Oya, R., Paoletti, J. M., Parede, M., Pasanen, D., Pascoli, F., Pau, R. G., Pegna, M. A., Perez Torre, M., Persic, L., Peruzzo, F., Prada, E., Prandini, N., Puchade, I., Reichardt, W., Rhode, M., Ribo, J., Rico, M., Rissi, A., Robert, S., Rugamer, A., Saggion, T. Y., Saito, M., Salvati, M., Sanchez Conde, K., Satalecka, V., Scalzotto, V., Scapin, T., Schweizer, M., Shayduk, S. N., Shore, N., Sidro, A., Sierpowska Bartosik, A., Sillanpaa, J., Sitarek, D., Sobczynska, F., Spanier, A., Stamerra, L. S., Stark, L., Takalo, F., Tavecchio, P., Temnikov, D., Tescaro, M., Teshima, D. F., Torre, N., Turini, H., Vankov, R. M., Wagner, V., Zabalza, F., Zandanel, R., Zanin, and J., Zapatero
Subjects: m87 jet, Radio galaxy, Astrophysics, telescope, 01 natural sciences, Astroparticle, Jets (Astrofísica), Radio astronomy, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, tev emission, Multidisciplinary, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Gamma ray, 3. Good health, Forats negres (Astronomia), Radioastronomia, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, Very High Energy Gamma-ray Astronomy, MAGIC telescope, Galaxies, Radio wave, outburst, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Active galactic nucleus, inner jet, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, X-shaped radio galaxy, veritas, 0103 physical sciences, Nucli galàctic actiu, crab-nebula, VHE Gamma ray, Astrophysics::Galaxy Astrophysics, Active galactic nuclei, variability, 010308 nuclear & particles physics, nucleus, Astronomy, Astrophysics - Astrophysics of Galaxies, Galaxy, Accretion (astrophysics), Astrophysical jets, Black hole, Cherenkov telescope, Astrophysics of Galaxies (astro-ph.GA), Black holes (Astronomy), supermassive black-hole
Abstract: The accretion of matter onto a massive black hole is believed to feed the relativistic plasma jets found in many active galactic nuclei (AGN). Although some AGN accelerate particles to energies exceeding 10^12 electron Volts (eV) and are bright sources of very-high-energy (VHE) gamma-ray emission, it is not yet known where the VHE emission originates. Here we report on radio and VHE observations of the radio galaxy M87, revealing a period of extremely strong VHE gamma-ray flares accompanied by a strong increase of the radio flux from its nucleus. These results imply that charged particles are accelerated to very high energies in the immediate vicinity of the black hole., Comment: 21 pages, 5 figures, published in Science, see: http://www.sciencemag.org/cgi/content/abstract/325/5939/444
Published: 2009
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42. MULTIWAVELENGTH OBSERVATIONS OF A TeV-FLARE FROM W COMAE

Author: Veritas, Collaboration, Acciari, V. A., Aliu, E., Aune, T., Beilicke, M., Benbow, W., Bottcher, M., Boltuch, D., Buckley, J. H., Bradbury, S. M., Bugaev, V., Byrum, K., Cannon, A., Cesarini, A., Ciupik, L., Cogan, P., Cui, W., Dickherber, R., Duke, C., Falcone, A., Finley, J. P., Fortin, P., Fortson, L., Furniss, A., Galante, N., Gall, D., Gibbs, K., Gillanders, G. H., Grube, J., Guenette, R., Gyuk, G., Hanna, D., Holder, J., Hui, C. M., Humensky, T. B., Kaaret, P., Karlsson, N., Kertzman, M., Kieda, D., Konopelko, A., Krawczynski, H., Krennrich, F., Lang, M. J., Lebohec, S., Maier, G., Mcarthur, S., Mccann, A., Mccutcheon, M., Millis, J., Moriarty, P., Ong, R. A., Otte, A. N., Pandel, D., Perkins, J. S., Pichel, A., Pohl, M., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Roache, E., Rose, H. J., Sembroski, G. H., Smith, A. W., Steele, D., Theiling, M., Thibadeau, S., Varlotta, A., Vassiliev, V. V., Vincent, S., Wakely, S. P., Ward, J. E., Weekes, T. C., Weinstein, A., Weisgarber, T., Williams, D. A., Wissel, S., Wood, M., Agile, The Team, Pian, E., Vercellone, S., Donnarumma, I., D Ammando, F., Bulgarelli, A., Chen, A. W., Giuliani, A., Longo, F., Pacciani, L., Pucella, G., Vittorini, V., Tavani, M., Argan, A., Barbiellini, G., Caraveo, P., Cattaneo, P. W., Cocco, V., Costa, E., Del Monte, E., Paris, G., Di Cocco, G., Evangelista, Y., Feroci, M., Fiorini, M., Froysland, T., Frutti, M., Fuschino, F., Galli, M., Gianotti, F., Labanti, C., Lapshov, I., Lazzarotto, F., Lipari, P., Marisaldi, M., Mastropietro, M., Mereghetti, S., Morelli, E., Morselli, A., Pellizzoni, A., Perotti, F., Piano, G., Picozza, P., Pilia, M., Porrovecchio, G., Prest, M., Rapisarda, M., Rappoldi, A., Rubini, A., Soffitta, S. Sabatini P., Trifoglio, M., Trois, A., Vallazza, E., Zambra, A., Zanello, D., Pittori, C., Santolamazza, P., Verrecchia, F., Giommi, P., Colafrancesco, S., Salotti, L., Massimo Villata, Raiteri, C. M., Aller, H. D., Aller, M. F., Arkharov, A. A., Efimova, N. V., Larionov, V. M., Leto, P., Ligustri, R., Lindfors, E., Pasanen, M., Kurtanidze, O. M., Tetradze, S. D., Lahteenmaki, A., Kotiranta, M., Cucchiara, A., Romano, P., Nesci, R., Pursimo, T., Heidt, J., Benitez, E., Hiriart, D., Nilsson, K., Berdyugin, A., Mujica, R., Dultzin, D., Lopez, J. M., Mommert, M., Sorcia, M., La Calle Perez, I., V. A., Acciari, E., Aliu, T., Aune, M., Beilicke, W., Benbow, M., Bottcher, D., Boltuch, J. H., Buckley, S. M., Bradbury, V., Bugaev, K., Byrum, A., Cannon, A., Cesarini, L., Ciupik, P., Cogan, W., Cui, R., Dickherber, C., Duke, A., Falcone, J. P., Finley, P., Fortin, L., Fortson, A., Furni, N., Galante, D., Gall, K., Gibb, G. H., Gillander, J., Grube, R., Guenette, G., Gyuk, D., Hanna, J., Holder, C. M., Hui, T. B., Humensky, P., Kaaret, N., Karlsson, M., Kertzman, D., Kieda, A., Konopelko, H., Krawczynski, F., Krennrich, M. J., Lang, S., Lebohec, G., Maier, S., Mcarthur, A., Mccann, M., Mccutcheon, J., Milli, P., Moriarty, R. A., Ong, A. N., Otte, D., Pandel, J. S., Perkin, A., Pichel, M., Pohl, J., Quinn, K., Ragan, L. C., Reye, P. T., Reynold, E., Roache, H. J., Rose, G. H., Sembroski, A. W., Smith, D., Steele, M., Theiling, S., Thibadeau, A., Varlotta, V. V., Vassiliev, S., Vincent, S. P., Wakely, J. E., Ward, T. C., Weeke, A., Weinstein, T., Weisgarber, D. A., William, S., Wissel, M., Wood, E., Pian, S., Vercellone, I., Donnarumma, F., D'Ammando, A., Bulgarelli, A. W., Chen, A., Giuliani, Longo, Francesco, L., Pacciani, G., Pucella, V., Vittorini, M., Tavani, A., Argan, G., Barbiellini, P., Caraveo, P. W., Cattaneo, V., Cocco, E., Costa, E. D., Monte, G. D., Pari, G. D., Cocco, Y., Evangelista, M., Feroci, M., Fiorini, T., Froysland, M., Frutti, F., Fuschino, M., Galli, F., Gianotti, C., Labanti, I., Lapshov, F., Lazzarotto, P., Lipari, M., Marisaldi, M., Mastropietro, S., Mereghetti, E., Morelli, A., Morselli, A., Pellizzoni, F., Perotti, G., Piano, P., Picozza, M., Pilia, G., Porrovecchio, M., Prest, M., Rapisarda, A., Rappoldi, A., Rubini, S., Sabatini, P., Soffitta, M., Trifoglio, A., Troi, E., Vallazza, A., Zambra, D., Zanello, C., Pittori, P., Santolamazza, F., Verrecchia, P., Giommi, S., Colafrancesco, L., Salotti, M., Villata, C. M., Raiteri, H. D., Aller, M. F., Aller, A. A., Arkharov, N. V., Efimova, V. M., Larionov, P., Leto, R., Ligustri, E., Lindfor, M., Pasanen, O. M., Kurtanidze, S. D., Tetradze, A., Lahteenmaki, M., Kotiranta, A., Cucchiara, P., Romano, R., Nesci, T., Pursimo, J., Heidt, E., Benitez, D., Hiriart, K., Nilsson, A., Berdyugin, R., Mujica, D., Dultzin, J. M., Lopez, M., Mommert, M., Sorcia, I. D., Perez, Acciari VA, Aliu E, Aune T, Beilicke M, Benbow W, Bottcher M, Boltuch D, Buckley JH, Bradbury SM, Bugaev V, Byrum K, Cannon A, Cesarini A, Ciupik L, Cogan P, Cui W, Dickherber R, Duke C, Falcone A, Finley JP, Fortin P, Fortson L, Furniss A, Galante N, Gall D, Gibbs K, Gillanders GH, Grube J, Guenette R, Gyuk G, Hanna D, Holder J, Hui CM, Humensky TB, Kaaret P, Karlsson N, Kertzman M, Kieda D, Konopelko A, Krawczynski H, Krennrich F, Lang MJ, LeBohec S, Maier G, McArthur S, McCann A, McCutcheon M, Millis J, Moriarty P, Ong RA, Otte AN, Pandel D, Perkins JS, Pichel A, Pohl M, Quinn J, Ragan K, Reyes LC, Reynolds PT, Roache E, Rose HJ, Sembroski GH, Smith AW, Steele D, Theiling M, Thibadeau S, Varlotta A, Vassiliev VV, Vincent S, Wakely SP, Ward JE, Weekes TC, Weinstein A, Weisgarber T, Williams DA, Wissel S, Wood M, Pian E, Vercellone S, Donnarumma I, DAmmando F, Bulgarelli A, Chen AW, Giuliani A, Longo F, Pacciani L, Pucella G, Vittorini V, Tavani M, Argan A, Barbiellini G, Caraveo P, Cattaneo PW, Cocco V, Costa E, Del Monte E, De Paris G, Di Cocco G, Evangelista Y, Feroci M, Fiorini M, Froysland T, Frutti M, Fuschino F, Galli M, Gianotti F, Labanti C, Lapshov I, Lazzarotto F, Lipari P, Marisaldi M, Mastropietro M, Mereghetti S, Morelli E, Morselli A, Pellizzoni A, Perotti F, Piano G, Picozza P, Pilia M, Porrovecchio G, Prest M, Rapisarda M, Rappoldi A, Rubini A, Sabatini S, Soffitta P, Trifoglio M, Trois A, Vallazza E, Zambra A, Zanello D, Pittori C, Santolamazza P, Verrecchia F, Giommi P, Colafrancesco S, Salotti L, Villata M, Raiteri CM, Aller HD, Aller MF, Arkharov AA, Efimova NV, Larionov VM, Leto P, Ligustri R, Lindfors E, Pasanen M, Kurtanidze OM, Tetradze SD, Lahteenmaki A, Kotiranta M, Cucchiara A, Romano P, Nesci R, Pursimo T, Heidt J, Benitez E, Hiriart D, Nilsson K, Berdyugin A, Mujica R, Dultzin D, Lopez JM, Mommert M, Sorcia M, and Perez ID
Subjects: Agile, High energy, agile space mission, Astrophysics::High Energy Astrophysical Phenomena, bl-lacertae objects, FOS: Physical sciences, Flux, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, telescope, 01 natural sciences, High Energy Gamma-ray Astronomy, blazar, law.invention, multiwavelength, BL Lacertae, law, 0103 physical sciences, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 010308 nuclear & particles physics, Very High Energy Gamma-ray Astronomy, AGILE satellite, Active Galactic Nuclei, Gamma ray, background-radiation, Astronomy and Astrophysics, gamma-ray emission, lac objects, spectral energy-distributions, veritas observations, Space and Planetary Science, source list, Spectral energy distribution, BL Lacertae objects: individual (W Com), Astrophysics - High Energy Astrophysical Phenomena, gamma rays: observations, Flare, BL Lac object
Abstract: We report results from an intensive multiwavelength campaign on the intermediate-frequency-peaked BL Lacertae object W Com (z=0.102) during a strong outburst of very high energy gamma-ray emission in June 2008. The very high energy gamma-ray signal was detected by VERITAS on 2008 June 7-8 with a flux F(>200 GeV) = (5.7+-0.6)x10^-11 cm-2s-1, about three times brighter than during the discovery of gamma-ray emission from W Com by VERITAS in 2008 March. The initial detection of this flare by VERITAS at energies above 200 GeV was followed by observations in high energy gamma-rays (AGILE, E>100 MeV), and X-rays (Swift and XMM-Newton), and at UV, and ground-based optical and radio monitoring through the GASP-WEBT consortium and other observatories. Here we describe the multiwavelength data and derive the spectral energy distribution (SED) of the source from contemporaneous data taken throughout the flare., 26 pages, 5 figures; Accepted for publication by The Astrophysical Journal
Published: 2009

43. Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy

Author: K. Ziȩtara, A. Konopelko, J. Rico, Philippe Laporte, Tatsuo Yoshida, A. Etchegoyen, Dennis Haefner, C. Morello, L. Garrido, Philip Kaaret, T. Yamamoto, F. Di Pierro, Wystan Benbow, B. Sacco, T. O. B. Schmidt, T. Krähenbühl, N. Geffroy, I. M. McHardy, Toru Tanimori, A. Salini, F. Grañena, A. Liolios, A. C. Rovero, A. Mendes, Etienne Lyard, Juan Abel Barrio, Jürgen Schmoll, R. Dubois, A. N. Otte, J. Bolmont, S. Rivoire, K. Berger, A. Nikolaidis, J.-P. Ernenwein, A. Bobkov, D. Allan, C. Schultz, Masayuki Tanaka, G. Deleglise, Oliver Grimm, Ł. Płatos, O. Tibolla, M. Gochna, S. Schwarzburg, H. Arnaldi, Hiromitsu Takahashi, Valerie Connaughton, Adriano Fontana, D. Nedbal, P. Jean, Alejandro Ibarra, S. Spyrou, Gustavo E. Romero, Judith H. Croston, F. Feinstein, L. Tibaldo, M. Benallou, Shinji Hara, D. Florin, A. E. Szymkowiak, J.L. Van der Walt, Stefano Covino, Shigehiro Nagataki, G. Busetto, P. Nayman, G. Lamanna, William J. Potter, Tadashi Kifune, O. Corpace, M. Bourgeat, N. Webb, J. K. Becker, K. Hultquist, P. Majumdar, Anna Szostek, M. Compin, Petter Hofverberg, Dimitrios Emmanoulopoulos, J. Ingjald, R. Kossakowski, A. Mangano, Kunihito Ioka, Jonathan Granot, S. Buson, P. Manigot, J. M. Paredes, M. Gómez Berisso, Massimiliano Belluso, A. Kretzschmann, M. Stodulski, L. Venter, Artemio Herrero, Nu. Komin, German Hermann, Dorota Sobczyńska, Reinhard Schlickeiser, Akira Okumura, Felix Spanier, Gareth Hughes, J. Carr, Antonio Stamerra, Norita Kawanaka, T. Shibata, R. C. Shellard, Dieter H. H. Hoffmann, B. Yoffo, T. Dettlaff, R. G. Talbot, L. Fresnillo, A. Manalaysay, I. Jung, Kohta Murase, Geza Gyuk, C. Farnier, J. C. Marin, Julian Sitarek, Francesco Dazzi, H. Ohka, C. Skole, C. Ghag, Patrick Vogler, M. Hauser, M. Cailles, K. Nishijima, Yutaka Fujita, J. Berdugo, Luke O'c. Drury, Naoto Sakaki, F. Köck, P. Sutcliffe, Luis Ángel Tejedor, Hugh Dickinson, Denis Bastieri, Q. Weitzel, Ryoji Enomoto, Josep Colomé, Luigi Lessio, B. Peyaud, C. L. Naumann, Michael Punch, S. Rodriguez, Lucy Fortson, J. P. Osborne, J. Kotula, Piero Giubilato, J. Dyks, W. Kluźniak, T. Schweizer, M. Rataj, Allan Hallgren, Matthew Wood, David Gascon, M. Doert, R. Wawrzaszek, Daniela Hadasch, H. Castarede, P. Wawer, M. Kapala, J.-M. Reymond, A.A. Zdziarski, E. De Cea del Pozo, K. Farakos, D. Corti, A. St. J. Murphy, Mosè Mariotti, Kazutaka Yamaoka, T. C. Arlen, Christian Fruck, Francesco Russo, Stefano Gabici, T. Bernardino, B. Khélifi, B. Huber, T. Glanzman, J. Michałowski, Mark I. Wilkinson, M. Suchenek, Massimo Persic, I. Monteiro, M. I. Martínez, V. Sahakian, R. Firpo, Seth Digel, V. La Parola, F. Roy, Regis Terrier, E. Fokitis, E. de Oña Wilhelmi, D. Melkumyan, E. Edy, Stefano Basso, J. Knapp, Cameron B Rulten, A. Niedźwiecki, Karol Seweryn, Karl-Heinz Sulanke, B. Rudak, V. Scapin, R. Wischnewski, Ricardo Graciani, Gianluca Giavitto, Matthias Beilicke, K. Nakayama, Thomas Schanz, A. Sillanpää, G. Motta, Yoshiyuki Inoue, Elina Lindfors, Hannes Jensen, Henric Krawczynski, Catherine Boisson, C. Medina, Dinko Dimitrov, Karen Byrum, M. Shayduk, Gianpiero Tagliaferri, Richard White, Kazunori Kohri, I. Oya, T. Greenshaw, C. Olivetto, Tomasz Szepieniec, R. D. Parsons, Fuyuki Tokanai, Jerzy Grygorczuk, V. Scalzotto, S. Rosier-Lees, Dainis Dravins, Jacco Vink, Włodzimierz Piechocki, F. Stinzing, Felix Ryde, P. Ristori, N. A. McCubbin, M. Hayashida, Martin J. Hardcastle, G.W. Fraser, S. Paiano, S. Blake, U. Barres de Almeida, S. Federici, M. Corlier, C. J. Todero Peixoto, Łukasz Stawarz, Michael S. Briggs, Yvonne Becherini, Martin Pohl, Daniel Mazin, B. Decerprit, Yukikatsu Terada, J. F. Huppert, P. J. Rajda, Justin Vandenbroucke, S. Schlenstedt, S. Renner, Ł. Wiśniewski, Dieter Horns, T. B. Humensky, Takeshi Nakamori, Andreas Quirrenbach, Asdrúbal Enrique Bottani, P. Vallania, B. García, H. von Gunten, Alkiviadis F. Bais, Takashi Saito, Marcos Daniel Actis, Jacek Niemiec, W. Gäbele, C. van Eldik, Olaf Reimer, P. Corona, Robert D. Preece, C. Reimann, Pierre Brun, Thomas Bretz, R. Moderski, Eric Delagnes, Gilles Henri, W. Domainko, P. H. Tam, J. Schultze, A. Weinstein, M. Schroedter, A. Vollhardt, Stavros Maltezos, A. Wierzcholska, P. M. Chadwick, Fabrice Mottez, S. Steiner, M. Dyrda, S. Sun, Victor Stamatescu, M. Bogdan, Felix Aharonian, Hajime Takami, M. Winde, Evgeni Ovcharov, M. Panter, Shohei Yanagita, T. Jogler, Thomas Kihm, P. Micolon, S. J. Nolan, David A. Williams, Joachim Hahn, Q. Xiong, Nikolaos Stergioulas, J. Gaweda, R. Mirzoyan, Nektarios Vlahakis, J. Becerra, N. Fouque, M. Ribordy, V. Vassiliev, Claes Fransson, R. L. C. Starling, J. M. Huet, J. Ruppel, J.-P. Lenain, Enrico Giro, J. Ripken, T. Haubold, A. Lopatin, Joseph Silk, J. Borkowski, P. Lubinski, T. Le Flour, R. Platzer, A. Di Paolo, Reiko Orito, O. C. de Jager, C. Eleftheriadis, A. Gonzalez, T. J. L. McComb, U. Schwanke, S. Brau-Nogue, Yutaka Ohira, Philipp Mertsch, Daniel Ferenc, Maria Concetta Maccarone, F. Gonzalez, V. Golev, Osvaldo Catalano, V. Bugaev, C. Clerc, Michał Szanecki, C. Delgado, L. Pogosyan, M. Renaud, G. Pivato, Sabine Elles, E. J. Quel, R. J. García López, M. Videla, Stefan Funk, H. Vankov, A. Le Padellec, Michele Doro, Saverio Lombardi, S. Pita, A. Wolczko, G. Disset, U. Roeser, Abraham D. Falcone, I. Telezhinsky, S. Artmann, Pierre Colin, M. Chikawa, Daniela Dorner, G. Fontaine, Wolfgang Rhode, C. Baixeras, K. Mori, H. Prokoph, Giancarlo Cusumano, J. L. Dournaux, F. Toussenel, C. Dufour, Ilana M. Braun, Riccardo Paoletti, A. R. Knappy, Sergio Billotta, F. Krennrich, S. Karkar, Anne M. Green, Takanori Yoshikoshi, I. de la Calle Perez, Masahiro Teshima, M. Janiak, C. Stegmann, H. Wetteskind, Marco Tavani, Kostas D. Kokkotas, C. Föhr, J. L. Panazol, S. Cantu, C. Tenzer, I. Vegas, M. Grudzińska, Elisabetta Bissaldi, S. Bajtlik, A. Jacholkowska, P. Małkiewicz, M. Ostrowski, Reshmi Mukherjee, Mario Meucci, Tarek M. Hassan, W. Bednarek, Rodolfo Canestrari, Stefan Wagner, Teresa Mineo, N. Karlsson, M. Tluczykont, A. E. Suárez, David Kieda, R. Steenkamp, Grzegorz Kowal, C. Gasq, Loukas Vlahos, Kathrin Egberts, K. Kosack, A. D. Supanitsky, Hernán Asorey, Adriano Ghedina, Frank M. Rieger, P. Zychowski, J. Bähr, P. Wegner, P. Ziółkowski, Shigeto Kabuki, G. Papyan, Dario Hrupec, P. T. O'Brien, Oscar Blanch, Tsunefumi Mizuno, Robert Wagner, Thomas Lohse, Susumu Inoue, U. Straumann, J. Kushida, Jose Luis Contreras, C. Maña, Matteo Cerruti, P. Antoranz, Ll. Font, R. Sugawara, M. Casiraghi, C. Kalkuhl, Subir Sarkar, Jelena Aleksić, Juan Cortina, J. Pallota, L. Brunetti, Petar Temnikov, Tomasz Bulik, L. O. Takalo, G. Vasileiadis, Riccardo Rando, J. H. Buckley, V. de Souza, Sera Markoff, G. Pareschi, P. Kostka, J. Grube, M. Tokarz, Manel Errando, David Fink, C. Barbier, Marek Sikora, J. P. Tavernet, Yasushi Fukazawa, Werner Hofmann, K. Takahashi, B. Wagner, David Paneque, M. Barcelo, L. Guglielmi, S. Royer, Rika Hagiwara, Nestor Mirabal, R. A. Cameron, R. Walter, G. De La Vega, Jim Hinton, Garret Cotter, M. Sofo Haro, Peter Walter, R. Gredig, S. Vorobiov, A. Bouvier, B. Lieunard, V. A. Kudryavtsev, Mauro Ghigo, John H. Seiradakis, Konrad Bernlöhr, M. de Naurois, A. Yoshida, F. Sánchez, K. Katarzyński, C. Veyssiere, Leszek Bogacz, B. Moal, A. Reimer, J. Koziol, Thomas J. Maccarone, G. Pojmanski, E. Carmona, C. Bauer, Andreu Sanuy, V. J. Guarino, Marc Ribó, Vincenzo Testa, H. Huan, C. Jablonski, Tsuguya Naito, C. Lavalley, M. Karczewski, G. Agnetta, Giovanni Bonanno, A. Zajczyk, C. Díaz, J. Kasperek, E. Lorenz, P. Vincent, K. Saito, S. Cazaux, S. Selmane, B. Kȩdziora, Y. A. Gallant, Serena Mattiazzo, Emilio Molinari, N. La Barbera, Hidetoshi Kubo, M. K. Daniel, Katsuaki Asano, Tanyu Bonev, A. Cillis, L. A. Otero, Gernot Maier, M. Cieślar, M. Ciesielska, Shuichi Gunji, E. Gianakaki, E. M. de Gouveia Dal Pino, Apostolos Mastichiadis, S. P. Wakely, G. La Rosa, C. Boutonnet, V. Zitelli, I. Ochoa, M. Raue, E. Fillin-Martino, Ingomar Allekotte, J. P. Vialle, G. Vallejo, Ryo Yamazaki, C. Tchernin, Anna Barnacka, Andrea Santangelo, P. Ringegni, James Chiang, Aya Bamba, B. Giebels, A. Förster, Heide Costantini, N. Galante, R. S. Warwick, Michiko Ohishi, O. Reimann, Guillaume Dubus, K. Kodani, Olga Botner, Andreas Zech, Paolo De Coppi, Louis Antonelli, A. Pepato, A. De Angelis, M. Scarcioffolo, E. M. Santos, Christoph Deil, T. Bird, T. Kneiske, Daniele Spiga, B. Behera, Jürgen Knödlseder, L. Rob, G. Pedaletti, P. Munar, J.F. Glicenstein, Aris Karastergiou, A. Djannati-Ataï, B. Courty, R. A. Ong, J. Dick, Paolo Conconi, S. Giarrusso, G. Maneva, E. Salazar, A. Saggion, E. Birsin, Adrian Biland, Markus Gaug, Gino Tosti, M. Á. Sánchez Conde, Abelardo Moralejo, Chad Finley, J. D. Ponz, Hideaki Katagiri, A. M. Lopez, G. Pühlhofer, M. Yonetani, Emmanuel Moulin, E. Aliu, R. Kankanyan, Hiroyasu Tajima, F. Mirabel, Jan Conrad, R. Sternberger, Diego F. Torres, P.H. Carton, P.-O. Petrucci, L. Sapozhnikov, A. Schulz, J. Krause, B. De Lotto, J. P. Finley, J. Boix, Volker Beckmann, S. Klepser, Jun Kakuwa, Dimitris Balis, Hironori Matsumoto, R. Welsing, Matthew R. Orr, Dominique Durand, O. Luz, Nina Nowak, J. M. Illa, A. Aravantinos, P. Romano, A. Oziȩbło, Alessandro Carosi, Keith Bechtol, Elisa Prandini, S. Cavazzani, A. Zagdański, Francesca Volpe, Helene Sol, Ryan Heller, S. Vercellone, A. Bonardi, D. Garrido, Jose Miguel Miranda, Jürgen Barnstedt, Hiroshi Muraishi, Nathan Smith, D. Naumann, German Martinez, F.C. Antico, Kenji Toma, B. Cerruti, S. Couturier, R. Bühler, A. Gadola, F. Guilloux, M. Paz Arribas, F. Dubois, Victor Zabalza, A. G. Akhperjanian, Eckhard Kendziorra, Tomonori Totani, Universitat de Barcelona, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), APC - Astrophysique des Hautes Energies (APC - AHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), CTA, High Energy Astrophys. & Astropart. Phys (API, FNWI), CTA Collaboration, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), M., Acti, G., Agnetta, F., Aharonian, A., Akhperjanian, J., Aleksic, E., Aliu, D., Allan, I., Allekotte, F., Antico, L. A., Antonelli, P., Antoranz, A., Aravantino, T., Arlen, H., Arnaldi, S., Artmann, K., Asano, H., Asorey, J., Baehr, A., Bai, C., Baixera, S., Bajtlik, D., Bali, A., Bamba, C., Barbier, M., Barcelo, A., Barnacka, J., Barnstedt, U. B., De, J. A., Barrio, S., Basso, D., Bastieri, C., Bauer, J., Becerra, Y., Becherini, K., Bechtol, J., Becker, V., Beckmann, W., Bednarek, B., Behera, M., Beilicke, M., Belluso, M., Benallou, W., Benbow, J., Berdugo, K., Berger, T., Bernardino, K., Bernloehr, A., Biland, S., Billotta, T., Bird, E., Birsin, Bissaldi, Elisabetta, S., Blake, O., Blanch, A. A., Bobkov, L., Bogacz, M., Bogdan, C., Boisson, J., Boix, J., Bolmont, G., Bonanno, A., Bonardi, T., Bonev, J., Borkowski, O., Botner, A., Bottani, M., Bourgeat, C., Boutonnet, A., Bouvier, S., Brau Nogue, I., Braun, T., Bretz, M. S., Brigg, P., Brun, L., Brunetti, H., Buckley, V., Bugaev, R., Buehler, T., Bulik, G., Busetto, S., Buson, K., Byrum, M., Caille, R., Cameron, R., Canestrari, S., Cantu, E., Carmona, A., Carosi, J., Carr, P. H., Carton, M., Casiraghi, H., Castarede, O., Catalano, S., Cavazzani, S., Cazaux, B., Cerruti, M., Cerruti, M., Chadwick, J., Chiang, M., Chikawa, M., Cieslar, M., Ciesielska, A., Cilli, C., Clerc, P., Colin, J., Colome, M., Compin, P., Conconi, V., Connaughton, J., Conrad, J. L., Contrera, P., Coppi, M., Corlier, P., Corona, O., Corpace, D., Corti, J., Cortina, H., Costantini, G., Cotter, B., Courty, S., Couturier, S., Covino, J., Croston, G., Cusumano, M. K., Daniel, F., Dazzi, A., Deangeli, E. d., Cea, E. M., De, O. d., Jager, I. d., La, G. D., La, B. D., Lotto, M. d., Nauroi, E. d., Ona, V. d., Souza, B., Decerprit, C., Deil, E., Delagne, G., Deleglise, C., Delgado, T., Dettlaff, A. D., Paolo, F. D., Pierro, C., Diaz, J., Dick, H., Dickinson, S. W., Digel, D., Dimitrov, G., Disset, A., Djannati Ata, M., Doert, W., Domainko, D., Dorner, M., Doro, J. . ., L., D., Dravin, L., Drury, F., Duboi, R., Duboi, G., Dubu, C., Dufour, D., Durand, J., Dyk, M., Dyrda, E., Edy, K., Egbert, C., Eleftheriadi, S., Elle, D., Emmanoulopoulo, R., Enomoto, J. . ., P., M., Errando, A., Etchegoyen, A. D., Falcone, K., Farako, C., Farnier, S., Federici, F., Feinstein, D., Ferenc, E., Fillin Martino, D., Fink, C., Finley, J. P., Finley, R., Firpo, D., Florin, C., Foehr, E., Fokiti, L., Font, G., Fontaine, A., Fontana, A., Foerster, L., Fortson, N., Fouque, C., Fransson, G. W., Fraser, L., Fresnillo, C., Fruck, Y., Fujita, Y., Fukazawa, S., Funk, W., Gaebele, S., Gabici, A., Gadola, N., Galante, Y., Gallant, B., Garcia, R. J., Garcia, D., Garrido, L., Garrido, D., Gascon, C., Gasq, M., Gaug, J., Gaweda, N., Geffroy, C., Ghag, A., Ghedina, M., Ghigo, E., Gianakaki, S., Giarrusso, G., Giavitto, B., Giebel, E., Giro, P., Giubilato, T., Glanzman, J. . ., F., M., Gochna, V., Golev, M. G., Berisso, A., Gonzalez, F., Gonzalez, F., Granena, R., Graciani, J., Granot, R., Gredig, A., Green, T., Greenshaw, O., Grimm, J., Grube, M., Grudzinska, J., Grygorczuk, V., Guarino, L., Guglielmi, F., Guilloux, S., Gunji, G., Gyuk, D., Hadasch, D., Haefner, R., Hagiwara, J., Hahn, A., Hallgren, S., Hara, M. J., Hardcastle, T., Hassan, T., Haubold, M., Hauser, M., Hayashida, R., Heller, G., Henri, G., Hermann, A., Herrero, J. A., Hinton, D., Hoffmann, W., Hofmann, P., Hofverberg, D., Horn, D., Hrupec, H., Huan, B., Huber, J. . ., M., G., Hughe, K., Hultquist, T. B., Humensky, A., Ibarra, J. M., Illa, J., Ingjald, S., Inoue, Y., Inoue, K., Ioka, C., Jablonski, A., Jacholkowska, M., Janiak, P., Jean, H., Jensen, T., Jogler, I., Jung, P., Kaaret, S., Kabuki, J., Kakuwa, C., Kalkuhl, R., Kankanyan, M., Kapala, A., Karastergiou, M., Karczewski, S., Karkar, N., Karlsson, J., Kasperek, H., Katagiri, K., Katarzynski, N., Kawanaka, B., Kedziora, E., Kendziorra, B., Khelifi, D., Kieda, T., Kifune, T., Kihm, S., Klepser, W., Kluzniak, J., Knapp, A. R., Knappy, T., Kneiske, J., Knoedlseder, F., Koeck, K., Kodani, K., Kohri, K., Kokkota, N., Komin, A., Konopelko, K., Kosack, R., Kossakowski, P., Kostka, J., Kotula, G., Kowal, J., Koziol, T., Kraehenbuehl, J., Krause, H., Krawczynski, F., Krennrich, A., Kretzschmann, H., Kubo, V. A., Kudryavtsev, J., Kushida, N. L., Barbera, V. L., Parola, G. L., Rosa, A., Lopez, G., Lamanna, P., Laporte, C., Lavalley, T. L., Flour, A. L., Padellec, L., Lessio, B., Lieunard, E., Lindfor, A., Liolio, T., Lohse, S., Lombardi, A., Lopatin, E., Lorenz, P., Lubinski, O., Luz, E., Lyard, M. C., Maccarone, T., Maccarone, G., Maier, P., Majumdar, S., Maltezo, P., Malkiewicz, C., Mana, A., Manalaysay, G., Maneva, A., Mangano, P., Manigot, J., Marin, M., Mariotti, S., Markoff, G., Martinez, M., Martinez, A., Mastichiadi, H., Matsumoto, S., Mattiazzo, D., Mazin, T. J., L., N., Mccubbin, I., Mchardy, C., Medina, D., Melkumyan, A., Mende, P., Mertsch, M., Meucci, J., Michalowski, P., Micolon, T., Mineo, N., Mirabal, F., Mirabel, J. M., Miranda, R., Mirzoyan, T., Mizuno, B., Moal, R., Moderski, E., Molinari, I., Monteiro, A., Moralejo, C., Morello, K., Mori, G., Motta, F., Mottez, E., Moulin, R., Mukherjee, P., Munar, H., Muraishi, K., Murase, A. S., Murphy, S., Nagataki, T., Naito, T., Nakamori, K., Nakayama, C., Naumann, D., Naumann, P., Nayman, D., Nedbal, A., Niedzwiecki, J., Niemiec, A., Nikolaidi, K., Nishijima, S. J., Nolan, N., Nowak, P. T., O'Brien, I., Ochoa, Y., Ohira, M., Ohishi, H., Ohka, A., Okumura, C., Olivetto, R. A., Ong, R., Orito, M., Orr, J. P., Osborne, M., Ostrowski, L., Otero, A. N., Otte, E., Ovcharov, I., Oya, A., Ozieblo, S., Paiano, J., Pallota, J. L., Panazol, D., Paneque, M., Panter, R., Paoletti, G., Papyan, J. M., Parede, G., Pareschi, R. D., Parson, M. P., Arriba, G., Pedaletti, A., Pepato, M., Persic, P. O., Petrucci, B., Peyaud, W., Piechocki, S., Pita, G., Pivato, L., Plato, R., Platzer, L., Pogosyan, M., Pohl, G., Pojmanski, J. D., Ponz, W., Potter, E., Prandini, R., Preece, H., Prokoph, G., Puehlhofer, M., Punch, E., Quel, A., Quirrenbach, P., Rajda, R., Rando, M., Rataj, M., Raue, C., Reimann, O., Reimann, A., Reimer, O., Reimer, M., Renaud, S., Renner, W., Rhode, M., Ribo, M., Ribordy, J., Rico, F., Rieger, P., Ringegni, J., Ripken, P., Ristori, S., Rivoire, L., Rob, S., Rodriguez, U., Roeser, P., Romano, G. E., Romero, S., Rosier Lee, A. C., Rovero, F., Roy, S., Royer, B., Rudak, C. B., Rulten, J., Ruppel, F., Russo, F., Ryde, B., Sacco, A., Saggion, V., Sahakian, K., Saito, T., Saito, N., Sakaki, E., Salazar, A., Salini, F., Sanchez, M. A., Sanchez, A., Santangelo, E. M., Santo, A., Sanuy, L., Sapozhnikov, S., Sarkar, V., Scalzotto, V., Scapin, M., Scarcioffolo, T., Schanz, S., Schlenstedt, R., Schlickeiser, T., Schmidt, J., Schmoll, M., Schroedter, C., Schultz, J., Schultze, A., Schulz, U., Schwanke, S., Schwarzburg, T., Schweizer, J., Seiradaki, S., Selmane, K., Seweryn, M., Shayduk, R. C., Shellard, T., Shibata, M., Sikora, J., Silk, A., Sillanpaa, J., Sitarek, C., Skole, N., Smith, D., Sobczynska, M. S., Haro, H., Sol, F., Spanier, D., Spiga, S., Spyrou, V., Stamatescu, A., Stamerra, R. L., C., L., Stawarz, R., Steenkamp, C., Stegmann, S., Steiner, N., Stergioula, R., Sternberger, F., Stinzing, M., Stodulski, U., Straumann, A., Suarez, M., Suchenek, R., Sugawara, K. H., Sulanke, S., Sun, A. D., Supanitsky, P., Sutcliffe, M., Szanecki, T., Szepieniec, A., Szostek, A., Szymkowiak, G., Tagliaferri, H., Tajima, H., Takahashi, K., Takahashi, L., Takalo, H., Takami, R. G., Talbot, P. H., Tam, M., Tanaka, T., Tanimori, M., Tavani, C., Tchernin, L. A., Tejedor, I., Telezhinsky, P., Temnikov, C., Tenzer, Y., Terada, R., Terrier, M., Teshima, V., Testa, L., Tibaldo, O., Tibolla, M., Tluczykont, C. J., Todero, F., Tokanai, M., Tokarz, K., Toma, D. F., Torre, G., Tosti, T., Totani, F., Toussenel, P., Vallania, G., Vallejo, J. v., Der, C. v., Eldik, J., Vandenbroucke, H., Vankov, G., Vasileiadi, V. V., Vassiliev, I., Vega, L., Venter, S., Vercellone, C., Veyssiere, J. P., Vialle, M., Videla, P., Vincent, J., Vink, N., Vlahaki, L., Vlaho, P., Vogler, A., Vollhardt, F., Volpe, H. P., Von, S., Vorobiov, S., Wagner, R. M., Wagner, B., Wagner, S. P., Wakely, P., Walter, R., Walter, R., Warwick, P., Wawer, R., Wawrzaszek, N., Webb, P., Wegner, A., Weinstein, Q., Weitzel, R., Welsing, H., Wetteskind, R., White, A., Wierzcholska, M. I., Wilkinson, D. A., William, M., Winde, R., Wischnewski, L., Wisniewski, A., Wolczko, M., Wood, Q., Xiong, T., Yamamoto, K., Yamaoka, R., Yamazaki, S., Yanagita, B., Yoffo, M., Yonetani, A., Yoshida, T., Yoshida, T., Yoshikoshi, V., Zabalza, A., Zagdanski, A., Zajczyk, A., Zdziarski, A., Zech, K., Zietara, P., Ziolkowski, V., Zitelli, and P., Zychowski
Subjects: Next generation Cherenkov telescopes, Ciencias Astronómicas, IACT, next generation Cherenkov telescopes, 01 natural sciences, 7. Clean energy, Design concepts, Ground based gamma ray astronomy, Observatory, Gamma ray astronomy, Instruments astronòmics, Ingeniería Aeronáutica, 010303 astronomy & astrophysics, media_common, Physics, Bursts, Radiation, Settore FIS/01 - Fisica Sperimentale, Astrophysics::Instrumentation and Methods for Astrophysics, Gamma-ray astronomy, Particles, Electrónica, Física nuclear, Magic Telescope, design concepts, Electricidad, Simulation, GAMMA-RAY PULSARS, Optical-System, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], ATMOSPHERIC CHERENKOV TELESCOPE, VHE Gamma ray, QUASAR, cosmic rays, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Cosmic ray, Partícules (Física nuclear), 0103 physical sciences, Astronomia de raigs gamma, 14. Life underwater, 1St Detection, Cherenkov radiation, Particles (Nuclear physics), Astroparticle physics, Telescopis, 010308 nuclear & particles physics, Institut für Physik und Astronomie, Astronomy, Astronomical instruments, Astronomy and Astrophysics, ASTROFÍSICA, Cosmic-Rays, Cherenkov Telescope Array, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Induced Air-Showers, Space and Planetary Science, Sky, Next generation Cherenkov telescope, Tev, ground based gamma ray astronomy, Telescopes
Abstract: Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA., La lista completa de autores que integran el documento puede consultarse en el archivo., Departamento de Aeronáutica, Facultad de Ingeniería, Instituto Argentino de Radioastronomía, Facultad de Ciencias Astronómicas y Geofísicas
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44. Detection of pulsed gamma rays above 100 GeV from the Crab pulsar.

Author: Aliu E, Arlen T, Aune T, Beilicke M, Benbow W, Bouvier A, Bradbury SM, Buckley JH, Bugaev V, Byrum K, Cannon A, Cesarini A, Christiansen JL, Ciupik L, Collins-Hughes E, Connolly MP, Cui W, Dickherber R, Duke C, Errando M, Falcone A, Finley JP, Finnegan G, Fortson L, Furniss A, Galante N, Gall D, Gibbs K, Gillanders GH, Godambe S, Griffin S, Grube J, Guenette R, Gyuk G, Hanna D, Holder J, Huan H, Hughes G, Hui CM, Humensky TB, Imran A, Kaaret P, Karlsson N, Kertzman M, Kieda D, Krawczynski H, Krennrich F, Lang MJ, Lyutikov M, Madhavan AS, Maier G, Majumdar P, McArthur S, McCann A, McCutcheon M, Moriarty P, Mukherjee R, Nuñez P, Ong RA, Orr M, Otte AN, Park N, Perkins JS, Pizlo F, Pohl M, Prokoph H, Quinn J, Ragan K, Reyes LC, Reynolds PT, Roache E, Rose HJ, Ruppel J, Saxon DB, Schroedter M, Sembroski GH, Sentürk GD, Smith AW, Staszak D, Tešić G, Theiling M, Thibadeau S, Tsurusaki K, Tyler J, Varlotta A, Vassiliev VV, Vincent S, Vivier M, Wakely SP, Ward JE, Weekes TC, Weinstein A, Weisgarber T, Williams DA, and Zitzer B
Abstract: We report the detection of pulsed gamma rays from the Crab pulsar at energies above 100 giga-electron volts (GeV) with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) array of atmospheric Cherenkov telescopes. The detection cannot be explained on the basis of current pulsar models. The photon spectrum of pulsed emission between 100 mega-electron volts and 400 GeV is described by a broken power law that is statistically preferred over a power law with an exponential cutoff. It is unlikely that the observation can be explained by invoking curvature radiation as the origin of the observed gamma rays above 100 GeV. Our findings require that these gamma rays be produced more than 10 stellar radii from the neutron star.
Published: 2011
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45. Radio imaging of the very-high-energy gamma-ray emission region in the central engine of a radio galaxy.

Author: Acciari VA, Aliu E, Arlen T, Bautista M, Beilicke M, Benbow W, Bradbury SM, Buckley JH, Bugaev V, Butt Y, Byrum K, Cannon A, Celik O, Cesarini A, Chow YC, Ciupik L, Cogan P, Cui W, Dickherber R, Fegan SJ, Finley JP, Fortin P, Fortson L, Furniss A, Gall D, Gillanders GH, Grube J, Guenette R, Gyuk G, Hanna D, Holder J, Horan D, Hui CM, Humensky TB, Imran A, Kaaret P, Karlsson N, Kieda D, Kildea J, Konopelko A, Krawczynski H, Krennrich F, Lang MJ, LeBohec S, Maier G, McCann A, McCutcheon M, Millis J, Moriarty P, Ong RA, Otte AN, Pandel D, Perkins JS, Petry D, Pohl M, Quinn J, Ragan K, Reyes LC, Reynolds PT, Roache E, Roache E, Rose HJ, Schroedter M, Sembroski GH, Smith AW, Swordy SP, Theiling M, Toner JA, Varlotta A, Vincent S, Wakely SP, Ward JE, Weekes TC, Weinstein A, Williams DA, Wissel S, Wood M, Walker RC, Davies F, Hardee PE, Junor W, Ly C, Aharonian F, Akhperjanian AG, Anton G, Barres de Almeida U, Bazer-Bachi AR, Becherini Y, Behera B, Bernlöhr K, Bochow A, Boisson C, Bolmont J, Borrel V, Brucker J, Brun F, Brun P, Bühler R, Bulik T, Büsching I, Boutelier T, Chadwick PM, Charbonnier A, Chaves RC, Cheesebrough A, Chounet LM, Clapson AC, Coignet G, Dalton M, Daniel MK, Davids ID, Degrange B, Deil C, Dickinson HJ, Djannati-Ataï A, Domainko W, Drury LO, Dubois F, Dubus G, Dyks J, Dyrda M, Egberts K, Emmanoulopoulos D, Espigat P, Farnier C, Feinstein F, Fiasson A, Förster A, Fontaine G, Füssling M, Gabici S, Gallant YA, Gérard L, Gerbig D, Giebels B, Glicenstein JF, Glück B, Goret P, Göhring D, Hauser D, Hauser M, Heinz S, Heinzelmann G, Henri G, Hermann G, Hinton JA, Hoffmann A, Hofmann W, Holleran M, Hoppe S, Horns D, Jacholkowska A, de Jager OC, Jahn C, Jung I, Katarzyński K, Katz U, Kaufmann S, Kendziorra E, Kerschhaggl M, Khangulyan D, Khélifi B, Keogh D, Kluźniak W, Kneiske T, Komin N, Kosack K, Lamanna G, Lenain JP, Lohse T, Marandon V, Martin JM, Martineau-Huynh O, Marcowith A, Maurin D, McComb TJ, Medina MC, Moderski R, Moulin E, Naumann-Godo M, de Naurois M, Nedbal D, Nekrassov D, Nicholas B, Niemiec J, Nolan SJ, Ohm S, Olive JF, de Oña Wilhelmi E, Orford KJ, Ostrowski M, Panter M, Paz Arribas M, Pedaletti G, Pelletier G, Petrucci PO, Pita S, Pühlhofer G, Punch M, Quirrenbach A, Raubenheimer BC, Raue M, Rayner SM, Renaud M, Rieger F, Ripken J, Rob L, Rosier-Lees S, Rowell G, Rudak B, Rulten CB, Ruppel J, Sahakian V, Santangelo A, Schlickeiser R, Schöck FM, Schröder R, Schwanke U, Schwarzburg S, Schwemmer S, Shalchi A, Sikora M, Skilton JL, Sol H, Spangler D, Stawarz Ł, Steenkamp R, Stegmann C, Stinzing F, Superina G, Szostek A, Tam PH, Tavernet JP, Terrier R, Tibolla O, Tluczykont M, van Eldik C, Vasileiadis G, Venter C, Venter L, Vialle JP, Vincent P, Vivier M, Völk HJ, Volpe F, Wagner SJ, Ward M, Zdziarski AA, Zech A, Anderhub H, Antonelli LA, Antoranz P, Backes M, Baixeras C, Balestra S, Barrio JA, Bastieri D, Becerra González J, Becker JK, Bednarek W, Berger K, Bernardini E, Biland A, Bock RK, Bonnoli G, Bordas P, Borla Tridon D, Bosch-Ramon V, Bose D, Braun I, Bretz T, Britvitch I, Camara M, Carmona E, Commichau S, Contreras JL, Cortina J, Costado MT, Covino S, Curtef V, Dazzi F, De Angelis A, De Cea del Pozo E, Delgado Mendez C, De los Reyes R, De Lotto B, De Maria M, De Sabata F, Dominguez A, Dorner D, Doro M, Elsaesser D, Errando M, Ferenc D, Fernández E, Firpo R, Fonseca MV, Font L, Galante N, García López RJ, Garczarczyk M, Gaug M, Goebel F, Hadasch D, Hayashida M, Herrero A, Hildebrand D, Höhne-Mönch D, Hose J, Hsu CC, Jogler T, Kranich D, La Barbera A, Laille A, Leonardo E, Lindfors E, Lombardi S, Longo F, López M, Lorenz E, Majumdar P, Maneva G, Mankuzhiyil N, Mannheim K, Maraschi L, Mariotti M, Martínez M, Mazin D, Meucci M, Miranda JM, Mirzoyan R, Miyamoto H, Moldón J, Moles M, Moralejo A, Nieto D, Nilsson K, Ninkovic J, Oya I, Paoletti R, Paredes JM, Pasanen M, Pascoli D, Pauss F, Pegna RG, Perez-Torres MA, Persic M, Peruzzo L, Prada F, Prandini E, Puchades N, Reichardt I, Rhode W, Ribó M, Rico J, Rissi M, Robert A, Rügamer S, Saggion A, Saito TY, Salvati M, Sanchez-Conde M, Satalecka K, Scalzotto V, Scapin V, Schweizer T, Shayduk M, Shore SN, Sidro N, Sierpowska-Bartosik A, Sillanpää A, Sitarek J, Sobczynska D, Spanier F, Stamerra A, Stark LS, Takalo L, Tavecchio F, Temnikov P, Tescaro D, Teshima M, Torres DF, Turini N, Vankov H, Wagner RM, Zabalza V, Zandanel F, Zanin R, and Zapatero J
Abstract: The accretion of matter onto a massive black hole is believed to feed the relativistic plasma jets found in many active galactic nuclei (AGN). Although some AGN accelerate particles to energies exceeding 10(12) electron volts and are bright sources of very-high-energy (VHE) gamma-ray emission, it is not yet known where the VHE emission originates. Here we report on radio and VHE observations of the radio galaxy Messier 87, revealing a period of extremely strong VHE gamma-ray flares accompanied by a strong increase of the radio flux from its nucleus. These results imply that charged particles are accelerated to very high energies in the immediate vicinity of the black hole.
Published: 2009
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