1. Synthèse, étude toxicologique et activité psychotrope de nouvelles arylidènpyridazin-3-ones N-substituées.
- Author
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BENMOUSSA, Adnane, KANYONGA, Pascal Manuele, ANSAR1, M’Hammed, ZELLOU, Amina, EL HARTI, J., LAMSAOURI, Jamal, FAOUZI, My Abbes, ZAHIDI, Ahmed, BENZIANE, Hamid, CHERRAH, Yahia, and TAOUFIK, Jamal
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ORGANIC compounds , *DIAZEPAM , *ANTIHYPERTENSIVE agents , *CARDIOTONIC agents , *MUSCLE relaxants , *THERAPEUTICS - Abstract
The oxygenated derivatives of pyridazin are known into therapeutic for the richness of their pharmacological potentials: antihypertensive and cardiotonic. Properties antibacteriennes are also mentioned in the literature. From these considerations, results the idea to synthesize and study new series of arylidenpyridazin-3-ones N-substituted on the toxicological level, but also, to explore their possible activity on the central nervous system, in particular the psychotropic activity. The study of the pharmacological activity has shown that these products are not toxic at therapeutic doses and possess sedative, muscle relaxant, anxiolytic effects, but do not present any hypnotic, or catalepsy effect. However, these three products potentiate synthesis to different degrees of the hypnotic effect diazepam. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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