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2. Outcomes of Skull Base Reconstruction

Author

Hernandez, Stephen C., Papagiannopoulos, Peter, Senior, Brent A., Kennedy, David W., AlQahtani, Abdulaziz A., editor, Castelnuovo, Paolo, editor, Casiano, Roy, editor, and Carrau, Ricardo L., editor

Published
2022
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5. Broncho‐Vaxom® (OM‐85 BV) soluble components stimulate sinonasal innate immunity

Author

Triantafillou, Vasiliki, Workman, Alan D, Patel, Neil N, Maina, Ivy W, Tong, Charles CL, Kuan, Edward C, Kennedy, David W, Palmer, James N, Adappa, Nithin D, Waizel‐Haiat, Salomon, and Cohen, Noam A

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Infectious Diseases, Lung, Nutrition, Good Health and Well Being, Adjuvants, Immunologic, Cell Extracts, Cells, Cultured, Cilia, Epithelial Cells, Humans, Immunity, Innate, Nasal Mucosa, Nitric Oxide, sinusitis, ciliary motility, therapeutics, immunotherapy, innate immunity, rhinosinusitis, Immunology, Clinical sciences
Abstract

BackgroundBroncho-Vaxom® (OM-85 BV) is an extract of infectious respiratory bacteria that is used as an immunostimulant outside of the United States for the prevention and treatment of bronchitis and rhinosinusitis. Prior studies have shown that use of OM-85 BV is associated with reduction in frequency of respiratory infection and decreased duration of antibiotic usage. However, the effects of OM-85 BV on respiratory mucosal innate immunity are unknown.MethodsHuman sinonasal epithelial cells were grown at an air-liquid interface (ALI). Ciliary beat frequency (CBF) and nitric oxide (NO) production in response to stimulation with OM-85 BV was measured in vitro. Pharmacologic inhibitors of bitter taste receptor (T2R) signaling were used to determine if this pathway was taste-receptor-mediated.ResultsApical application of OM-85 BV resulted in an NO-mediated increase in CBF (p

Published
2019

8. List of contributors

Author

Akar-Ghibril, Nicole, primary, Ale, Hanadys, additional, Anaya, Juan-Manuel, additional, Anstey, Karen M., additional, Awasthi, Smita, additional, Baker, Mary Grace, additional, Chambliss, Jeffrey M., additional, Chang, Christopher, additional, Chen, Meng, additional, Cheung, Hei Lam Helena, additional, Chitty-Lopez, Maria, additional, Chrisant, Maryanne, additional, Chu, Ka Hou, additional, Cosme-Blanco, Wilfredo, additional, Daley, Aparna, additional, Dimitriades, Victoria R., additional, Dowden, Amy, additional, Elsayed-Ali, Omar, additional, Feuille, Elizabeth J., additional, Fonacier, Luz, additional, Freij, Joudeh B., additional, Fung, Maxwell A., additional, Gaytán, Armando Partida, additional, Ge, Xiang, additional, Gebba, Jennifer, additional, Ghaffari, Gisoo, additional, Golpanian, Rachel Shireen, additional, Hathaway, Kathleen, additional, Heimall, Jennifer, additional, Hein, Nina, additional, Herrera Guerra, Angel A., additional, Horton, Rachel K, additional, Huang, Ke, additional, Hwang, Samuel T., additional, Kennedy, David W., additional, Kleiner, Gary, additional, Kline, Ahnika, additional, Kobrynski, Lisa J., additional, Kostandy, Erini Nessim, additional, Kuruvilla, Merin, additional, Lachmann, Helen J., additional, Lam, Wai Ching, additional, Lee, Gerald B., additional, Lee, Joyce S., additional, Lee, Min J., additional, Lehman, Heather K., additional, Leiding, Jennifer W., additional, Lejeune, Stéphanie, additional, Leung, Nicki Y.H., additional, Leung, Patrick S.C., additional, Liburd, Kyndra, additional, Lipman, Zoe Morgan, additional, Lu, Qianjin, additional, Lugo Reyes, Saul O., additional, Lyons, Jonathan J., additional, Lyu, Aiping, additional, Makol, Richika, additional, Mawhirt, Stephanie L., additional, McGrath, Eric, additional, Medina, Renata, additional, Nadeau, Kari, additional, Nkamba, Iris, additional, Nomula, Kranthi, additional, Ong, Peck Y., additional, Oriel, Roxanne C., additional, Otani, Iris M., additional, Park, Young Hwan, additional, Patkar, Rasika, additional, Peet, Claire J., additional, Permaul, Perdita, additional, Phipatanakul, Wanda, additional, Poowuttikul, Pavadee, additional, Ramirez, Lourdes, additional, Ranganathan Ganakammal, S., additional, Restrepo, Lucas, additional, Rodriguez, Marlen, additional, Rodríguez, Yhojan, additional, Rose, Nevenda Velikova, additional, Rush, Nia, additional, Sabella, Colleen M., additional, Sandhu, Amandeep, additional, Sani, Sonam, additional, Secord, Elizabeth, additional, Seth, Divya, additional, Shao, Tihong, additional, Shenderov, Faina, additional, Shih, Jennifer, additional, Shu, Shang An, additional, Sicherer, Scott H., additional, Simpson, Jessica, additional, Squire, Jacqueline D., additional, Sriaroon, Panida, additional, Stern, Heather, additional, Summerfield, Daniel D., additional, Sun, JinLyu, additional, Sweis, Auddie M., additional, Tison, Katherine L., additional, Vadakal, Siena, additional, Valentini, Kelly, additional, Vanijcharoenkarn, Kristine, additional, Viqar, Sehrish, additional, Wai, Christine Y.Y., additional, Walkiewicz, M., additional, Walter, Jolan E., additional, Wang, Julie, additional, Wiers-Shamir, Kristina, additional, Winters, Jeffrey L., additional, Wu, Haijing, additional, Xirasagar, S., additional, Xu, Jennifer, additional, Yosipovitch, Gil, additional, Zerbe, Christa, additional, Zhong, Lidan Linda, additional, Zhou, Suqing, additional, and Zhou, Xiaoying, additional

Published
2022
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10. Ectopic Pituitary Adenomas Presenting as Sphenoid or Clival Lesions: Case Series and Management Recommendations

Author

Tajudeen, Bobby A, Kuan, Edward C, Adappa, Nithin D, Han, Joseph K, Chandra, Rakesh K, Palmer, James N, Kennedy, David W, Wang, Marilene B, and Suh, Jeffrey D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Prevention, Neurosciences, pituitary adenoma, ectopic pituitary tumors, sphenoid tumors, clival tumors, Neurology & Neurosurgery, Dentistry
Abstract

Background An ectopic pituitary adenoma presenting as a clival or sphenoid mass is a rare clinical occurrence that may mislead the clinician and result in unnecessary interventions or potential medicolegal consequences. Here, we present one of the largest multi-institutional case series and review the literature with an emphasis on radiological findings and critical preoperative workup. Methods Retrospective chart review. Results Nine patients were identified with ectopic pituitary adenomas of the sphenoid or clivus. There were four females and five males. Median age was 60 years old (range, 36-73 years). The most common presenting symptom was headache (56%). Five (56%) patients presented with a mass arising from the clivus while four (44%) presented with a mass in the sphenoid. Six (67%) patients demonstrated biochemical evidence of hypersecretion on full endocrinology panel. All masses showed evidence of enhancement with gadolinium with a propensity for adjacent bone involvement. Lesions also had a predilection for growth toward the cavernous sinus, carotid artery, or sellar floor. Surgical intervention was performed in eight patients (89%). In eight patients (89%), tumors demonstrated immunoreactivity to prolactin. Conclusions Pituitary adenomas can rarely present as an isolated sphenoid or clival mass. Lesions displayed similar magnetic resonance imaging findings with an erosive growth pattern toward the sellar floor, cavernous sinus, or adjacent carotid artery. Patients with clival or parasellar lesions with comparable features should have a preoperative workup which includes prolactin level and alert the physician to consider an ectopic pituitary adenoma in the differential to prevent unnecessary surgery and potential complications.

Published
2017

14. International consensus statement on allergy and rhinology: Sinonasal tumors

Author

Kuan, Edward C., primary, Wang, Eric W., additional, Adappa, Nithin D., additional, Beswick, Daniel M., additional, London, Nyall R., additional, Su, Shirley Y., additional, Wang, Marilene B., additional, Abuzeid, Waleed M., additional, Alexiev, Borislav, additional, Alt, Jeremiah A., additional, Antognoni, Paolo, additional, Alonso‐Basanta, Michelle, additional, Batra, Pete S., additional, Bhayani, Mihir, additional, Bell, Diana, additional, Bernal‐Sprekelsen, Manuel, additional, Betz, Christian S., additional, Blay, Jean‐Yves, additional, Bleier, Benjamin S., additional, Bonilla‐Velez, Juliana, additional, Callejas, Claudio, additional, Carrau, Ricardo L., additional, Casiano, Roy R., additional, Castelnuovo, Paolo, additional, Chandra, Rakesh K., additional, Chatzinakis, Vasileios, additional, Chen, Simon B., additional, Chiu, Alexander G., additional, Choby, Garret, additional, Chowdhury, Naweed I., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Dagan, Roi, additional, Dalfino, Gianluca, additional, Dallan, Iacopo, additional, Dassi, Camila Soares, additional, de Almeida, John, additional, Tos, Angelo P. Dei, additional, DelGaudio, John M., additional, Ebert, Charles S., additional, El‐Sayed, Ivan H., additional, Eloy, Jean Anderson, additional, Evans, James J., additional, Fang, Christina H., additional, Farrell, Nyssa F., additional, Ferrari, Marco, additional, Fischbein, Nancy, additional, Folbe, Adam, additional, Fokkens, Wytske J., additional, Fox, Meha G., additional, Lund, Valerie J., additional, Gallia, Gary L., additional, Gardner, Paul A., additional, Geltzeiler, Mathew, additional, Georgalas, Christos, additional, Getz, Anne E., additional, Govindaraj, Satish, additional, Gray, Stacey T., additional, Grayson, Jessica W., additional, Gross, Bradley A., additional, Grube, Jordon G., additional, Guo, Ruifeng, additional, Ha, Patrick K., additional, Halderman, Ashleigh A., additional, Hanna, Ehab Y., additional, Harvey, Richard J., additional, Hernandez, Stephen C., additional, Holtzman, Adam L., additional, Hopkins, Claire, additional, Huang, Zhigang, additional, Huang, Zhenxiao, additional, Humphreys, Ian M., additional, Hwang, Peter H., additional, Iloreta, Alfred M., additional, Ishii, Masaru, additional, Ivan, Michael E., additional, Jafari, Aria, additional, Kennedy, David W., additional, Khan, Mohemmed, additional, Kimple, Adam J., additional, Kingdom, Todd T., additional, Knisely, Anna, additional, Kuo, Ying‐Ju, additional, Lal, Devyani, additional, Lamarre, Eric D., additional, Lan, Ming‐Ying, additional, Le, Hien, additional, Lechner, Matt, additional, Lee, Nancy Y., additional, Lee, Jivianne K., additional, Lee, Victor H., additional, Levine, Corinna G., additional, Lin, Jin‐Ching, additional, Lin, Derrick T., additional, Lobo, Brian C., additional, Locke, Tran, additional, Luong, Amber U., additional, Magliocca, Kelly R., additional, Markovic, Svetomir N., additional, Matnjani, Gesa, additional, McKean, Erin L., additional, Meço, Cem, additional, Mendenhall, William M., additional, Michel, Loren, additional, Na'ara, Shorook, additional, Nicolai, Piero, additional, Nuss, Daniel W., additional, Nyquist, Gurston G., additional, Oakley, Gretchen M., additional, Omura, Kazuhiro, additional, Orlandi, Richard R., additional, Otori, Nobuyoshi, additional, Papagiannopoulos, Peter, additional, Patel, Zara M., additional, Pfister, David G., additional, Phan, Jack, additional, Psaltis, Alkis J., additional, Rabinowitz, Mindy R., additional, Ramanathan, Murugappan, additional, Rimmer, Ryan, additional, Rosen, Marc R., additional, Sanusi, Olabisi, additional, Sargi, Zoukaa B., additional, Schafhausen, Philippe, additional, Schlosser, Rodney J., additional, Sedaghat, Ahmad R., additional, Senior, Brent A., additional, Shrivastava, Raj, additional, Sindwani, Raj, additional, Smith, Timothy L., additional, Smith, Kristine A., additional, Snyderman, Carl H., additional, Solares, C. Arturo, additional, Sreenath, Satyan B., additional, Stamm, Aldo, additional, Stölzel, Katharina, additional, Sumer, Baran, additional, Surda, Pavol, additional, Tajudeen, Bobby A., additional, Thompson, Lester D. R., additional, Thorp, Brian D., additional, Tong, Charles C. L., additional, Tsang, Raymond K., additional, Turner, Justin H., additional, Turri‐Zanoni, Mario, additional, Udager, Aaron M., additional, van Zele, Thibaut, additional, VanKoevering, Kyle, additional, Welch, Kevin C., additional, Wise, Sarah K., additional, Witterick, Ian J., additional, Won, Tae‐Bin, additional, Wong, Stephanie N., additional, Woodworth, Bradford A., additional, Wormald, Peter‐John, additional, Yao, William C., additional, Yeh, Chien‐Fu, additional, Zhou, Bing, additional, Palmer, James N., additional, Abiri, Arash, additional, Adams, Carrie D., additional, Ayoub, Noel F., additional, Bitner, Benjamin F., additional, Boyd, Jacob T., additional, Chang, Michael T., additional, Chapurin, Nikita, additional, Chaskes, Mark B., additional, Chua, Andy, additional, Chung, Sei Y., additional, Contrera, Kevin J., additional, Dilley, Katelyn K., additional, Dutra, André Zanette, additional, Eide, Jacob G., additional, Fenberg, Rachel, additional, Godse, Neal R., additional, Jawad, Basit, additional, Johnson, Jared, additional, Johnson, B. Jake, additional, Judd, Ryan, additional, Khalife, Sarah, additional, Khosravi, Pooya, additional, Kolarski, Mirko Manojlovic, additional, Kong, Keonho A., additional, Kshirsagar, Rijul S., additional, Lee, Joseph S., additional, Lin, Tian‐Yun, additional, McCormick, Justin P., additional, Melder, Katie, additional, Morse, Elliot, additional, Nguyen, Theodore V., additional, Norwood, Timothy G., additional, Pang, Jonathan C., additional, Parsel, Sean M., additional, Patel, Prayag S., additional, Ringel, Barak, additional, Schneider, Alexander L., additional, Spielman, Daniel B., additional, Spock, Todd, additional, and Vasudev, Milind, additional

Published
2023
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17. Orbital resection by intranasal technique (ORBIT): A new classification system for reporting endoscopically resectable primary benign orbital tumors

Author

Jafari, Aria, primary, Adappa, Nithin D., additional, Anagnos, Vincent J., additional, Campbell, Raewyn G., additional, Castelnuovo, Paolo, additional, Chalian, Ara, additional, Chambers, Christopher B., additional, Chitguppi, Chandala, additional, Dallan, Iacopo, additional, El Rassi, Edward, additional, Freitag, Suzanne K., additional, Fernandez Miranda, Juan C., additional, Ferreira, Manuel, additional, Gardner, Paul A., additional, Gudis, David A., additional, Harvey, Richard J., additional, Huang, Qian, additional, Humphreys, Ian M., additional, Kennedy, David W., additional, Lee, John Y.K., additional, Lehmann, Ashton E., additional, Locatelli, Davide, additional, McKinney, Kibwei A., additional, Moreau, Annie, additional, Nyquist, Gurston, additional, Palmer, James N., additional, Prepageran, Narayanan, additional, Pribitkin, Edmund A., additional, Rabinowitz, Mindy R., additional, Rosen, Marc R., additional, Sacks, Raymond, additional, Sharma, Dhruv, additional, Snyderman, Carl H., additional, Tonya Stefko, S., additional, Stokken, Janalee K., additional, Wang, Eric W., additional, Workman, Alan D., additional, Wu, Arthur W., additional, Yu, Jen Y., additional, Zhang, Matthew M., additional, Zhou, Bing, additional, and Bleier, Benjamin S., additional

Published
2023
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30. Open Access: Is There a Predator at the Door?

Author

Chandra, Rakesh, Fisher, Edward W., Jones, Terry M., Kennedy, David W., Kraus, Dennis H., Krouse, John H., Link, Michael, Lustig, Lawrence R., O’Malley, Bert W., Jr, Piccirillo, Jay F., Ruben, Robert, Sataloff, Robert T., Schwartz, Sandra, Sindwani, Raj, Smith, Richard J., Stewart, Michael G., Weber, Peter C., Welling, D. Bradley, and Youngs, Robin

Published
2018
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42. Electrically Conductive Bacterial Nanowires Produced by Shewanella oneidensis Strain MR-1 and Other Microorganisms

Author

Gorby, Yuri A., Yanina, Svetlana, McLean, Jeffrey S., Rosso, Kevin M., Moyles, Dianne, Dohnalkova, Alice, Beveridge, Terry J., Chang, In Seop, Kim, Byung Hong, Kim, Kyung Shik, Culley, David E., Reed, Samantha B., Romine, Margaret F., Saffarini, Daad A., Hill, Eric A., Shi, Liang, Elias, Dwayne A., Kennedy, David W., Pinchuk, Grigoriy, Watanabe, Kazuya, Ishii, Shun'ichi, Logan, Bruce, Nealson, Kenneth H., and Fredrickson, Jim K.

Published
2006
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43. Targeted gene expression profiling of inverted papilloma and squamous cell carcinoma

Author

Tong, Charles C. L., primary, Koptyra, Mateusz, additional, Raman, Pichai, additional, Rathi, Komal S., additional, Choudhari, Namrata, additional, Lin, Xiang, additional, Seckar, Tyler, additional, Wei, Zhi, additional, Kohanski, Michael A., additional, O'Malley, Bert W., additional, Cohen, Noam A., additional, Kennedy, David W., additional, Adappa, Nithin D., additional, Robertson, Erle S., additional, Baranov, Esther, additional, Kuan, Edward C., additional, Papagiannopoulos, Peter, additional, Jalaly, Jalal B., additional, Feldman, Michael D., additional, Storm, Phillip B., additional, Resnick, Adam C., additional, and Palmer, James N., additional

Published
2021
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45. Bitter and sweet taste receptors regulate human upper respiratory innate immunity

Author

Lee, Robert J., Kofonow, Jennifer M., Rosen, Philip L., Siebert, Adam P., Chen, Bei, Doghramji, Laurel, Xiong, Guoxiang, Adappa, Nithin D., Palmer, James N., Kennedy, David W., Kreindler, James L., Margolskee, Robert F., and Cohen, Noam A.

Subjects
Respiratory organs -- Physiological aspects -- Research, Immune system -- Research -- Physiological aspects, Taste buds -- Physiological aspects -- Research, Physiological research -- Physiological aspects -- Research, Cardiopulmonary system -- Physiological aspects -- Research, Health care industry
Abstract

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including secreted bacterial products. Here, using human primary sinonasal air-liquid interface cultures and tissue explants, we determined that activation of a subset of airway T2Rs expressed in nasal solitary chemosensory cells activates a calcium wave that propagates through gap junctions to the surrounding respiratory epithelial cells. The T2R-dependent calcium wave stimulated robust secretion of antimicrobial peptides into the mucus that was capable of killing a variety of respiratory pathogens. Furthermore, sweet taste receptor (T1R2/3) activation suppressed T2R-mediated antimicrobial peptide secretion, suggesting that T1R2/3-mediated inhibition of T2Rs prevents full antimicrobial peptide release during times of relative health. In contrast, during acute bacterial infection, T1R2/3 is likely deactivated in response to bacterial consumption of airway surface liquid glucose, alleviating T2R inhibition and resulting in antimicrobial peptide secretion. We found that patients with chronic rhinosinusitis have elevated glucose concentrations in their nasal secretions, and other reports have shown that patients with hyperglycemia likewise have elevated nasal glucose levels. These data suggest that increased glucose in respiratory secretions in pathologic states, such as chronic rhinosinusitis or hyperglycemia, promotes tonic activation of T1R2/3 and suppresses T2R-mediated innate defense. Furthermore, targeting T1R2/3-dependent suppression of T2Rs may have therapeutic potential for upper respiratory tract infections., Introduction Mucociliary clearance is the primary physical defense against inhaled pathogens, toxins, and particulates in the respiratory system (1) and is complemented by the generation of antimicrobial peptides (AMPs) and [...]

Published
2014
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47. Prognosis of Distant Metastatic Sites in Anterior Skull Base Malignancies.

Author

Kraft, Daniel O., Carey, Ryan M., Prasad, Aman, Rajasekaran, Karthik, Kohanski, Michael A., Kennedy, David W., Palmer, James N., Adappa, Nithin D., Newman, Jason G., and Brant, Jason A.

Subjects
LUNGS, SKULL base, PROPORTIONAL hazards models, ADENOID cystic carcinoma, PROGNOSIS, OVERALL survival, SURVIVAL rate
Abstract

Objective  This study aimed to provide information regarding the prognosis of patients presenting with metastatic anterior skull base malignancies based upon histology and site of distant metastasis (DM). Patients and Methods  The National Cancer Database was queried for patients with anterior skull base malignant neoplasms with DM. Outcomes  Prognosis was compared between site of DM and tumor histologies. A multivariable Cox proportional hazards model was used to identify prognostic factors for overall survival (OS). Results  A total of 481 patients were identified. Lung was the most common site of DM (24.9%), followed by bone (22.2%), liver (5.6%), and brain (2.5%). Lung was the most common site for squamous cell carcinoma (SCCa) (28.3%), melanoma (37.7%), and adenoid cystic carcinoma (ACC; 31.4%). The median survival for patients presenting with metastatic disease regardless of tumor histology was 9.0 months (95% confidence interval [CI]: 8.2–10.3), and patients with metastasis to the liver had the best median survival at 15.5 months (95% CI: 10.5–25.6). The median survivals for the most common histologies, SCCa, melanoma, and ACC were 8.2 months (95% CI: 5.5–10.2), 10.5 months (95% CI: 8.7–14.1), and 15.0 months (95% CI: 11.1–61.1), respectively. Multivariable analysis demonstrated worse overall survival (OS) for older patients, higher Charlson-Deyo comorbidity scores, and tumors with higher grade and T stage. Compared with metastasis to bone, lung metastasis had better OS on multivariable analysis (hazard ratio [HR]: 0.70, 95% CI: 0.51–97). Adenoid cystic carcinoma had improved OS compared with SCCa (HR: 0.62, 95% CI: 0.39–99). Conclusion  Tumor histology, metastatic sites, and several disease factors affected prognosis in anterior skull base malignancies with DM. [ABSTRACT FROM AUTHOR]

Published
2022
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