Author: "Kaaks, R. (Rudolf)" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Kaaks, R. (Rudolf)"' showing total 32 results

Start Over Author "Kaaks, R. (Rudolf)"

32 results on '"Kaaks, R. (Rudolf)"'

1. Common variants in breast cancer risk loci predispose to distinct tumor subtypes

Author: Ahearn, T. U. (Thomas U.), Zhang, H. (Haoyu), Michailidou, K. (Kyriaki), Milne, R. L. (Roger L.), Bolla, M. K. (Manjeet K.), Dennis, J. (Joe), Dunning, A. M. (Alison M.), Lush, M. (Michael), Wang, Q. (Qin), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Auer, P. L. (Paul L.), Augustinsson, A. (Annelie), Baten, A. (Adinda), Becher, H. (Heiko), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Blomqvist, C. (Carl), Bojesen, S. E. (Stig E.), Bonanni, B. (Bernardo), Borresen-Dale, A.-L. (Anne-Lise), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brooks-Wilson, A. (Angela), Bruening, T. (Thomas), Burwinkel, B. (Barbara), Buys, S. S. (Saundra S.), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Clarke, C. L. (Christine L.), Collee, J. M. (J. Margriet), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Dork, T. (Thilo), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Floris, G. (Giuseppe), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Gonzalez-Neira, A. (Anna), Alnaes, G. I. (Grethe I. Grenaker), Grip, M. (Mervi), Guenel, P. (Pascal), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hamann, U. (Ute), Harkness, E. F. (Elaine F.), Heemskerk-Gerritsen, B. A. (Bernadette A. M.), Holleczek, B. (Bernd), Hollestelle, A. (Antoinette), Hooning, M. J. (Maartje J.), Hoover, R. N. (Robert N.), Hopper, J. L. (John L.), Howell, A. (Anthony), Jakimovska, M. (Milena), Jakubowska, A. (Anna), John, E. M. (Esther M.), Jones, M. E. (Michael E.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kauppila, S. (Saila), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Ko, Y.-D. (Yon-Dschun), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Kruger, U. (Ute), Kubelka-Sabit, K. (Katerina), Kurian, A. W. (Allison W.), Kyriacou, K. (Kyriacos), Lambrechts, D. (Diether), Lee, D. G. (Derrick G.), Lindblom, A. (Annika), Linet, M. (Martha), Lissowska, J. (Jolanta), Llaneza, A. (Ana), Lo, W.-Y. (Wing-Yee), MacInnis, R. J. (Robert J.), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Margolin, S. (Sara), Martinez, M. E. (Maria Elena), McLean, C. (Catriona), Meindl, A. (Alfons), Menon, U. (Usha), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Nodora, J. (Jesse), Offit, K. (Kenneth), Olsson, H. (Hakan), Orr, N. (Nick), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa, V), Peto, J. (Julian), Pita, G. (Guillermo), Plaseska-Karanfilska, D. (Dijana), Prentice, R. (Ross), Punie, K. (Kevin), Pylkas, K. (Katri), Radice, P. (Paolo), Rennert, G. (Gad), Romero, A. (Atocha), Ruediger, T. (Thomas), Saloustros, E. (Emmanouil), Sampson, S. (Sarah), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Schoemaker, M. J. (Minouk J.), Schottker, B. (Ben), Sherman, M. E. (Mark E.), Shu, X.-O. (Xiao-Ou), Smichkoska, S. (Snezhana), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Torres, D. (Diana), Troester, M. A. (Melissa A.), Vachon, C. M. (Celine M.), van Deurzen, C. H. (Carolien H. M.), van Veen, E. M. (Elke M.), Wagner, P. (Philippe), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Wesseling, J. (Jelle), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Zheng, W. (Wei), Couch, F. J. (Fergus J.), Simard, J. (Jacques), Kraft, P. (Peter), Easton, D. F. (Douglas F.), Pharoah, P. D. (Paul D. P.), Schmidt, M. K. (Marjanka K.), Garcia-Closas, M. (Montserrat), Chatterjee, N. (Nilanjan), Ahearn, T. U. (Thomas U.), Zhang, H. (Haoyu), Michailidou, K. (Kyriaki), Milne, R. L. (Roger L.), Bolla, M. K. (Manjeet K.), Dennis, J. (Joe), Dunning, A. M. (Alison M.), Lush, M. (Michael), Wang, Q. (Qin), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Auer, P. L. (Paul L.), Augustinsson, A. (Annelie), Baten, A. (Adinda), Becher, H. (Heiko), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Blomqvist, C. (Carl), Bojesen, S. E. (Stig E.), Bonanni, B. (Bernardo), Borresen-Dale, A.-L. (Anne-Lise), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brooks-Wilson, A. (Angela), Bruening, T. (Thomas), Burwinkel, B. (Barbara), Buys, S. S. (Saundra S.), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Clarke, C. L. (Christine L.), Collee, J. M. (J. Margriet), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Dork, T. (Thilo), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Floris, G. (Giuseppe), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Gonzalez-Neira, A. (Anna), Alnaes, G. I. (Grethe I. Grenaker), Grip, M. (Mervi), Guenel, P. (Pascal), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hamann, U. (Ute), Harkness, E. F. (Elaine F.), Heemskerk-Gerritsen, B. A. (Bernadette A. M.), Holleczek, B. (Bernd), Hollestelle, A. (Antoinette), Hooning, M. J. (Maartje J.), Hoover, R. N. (Robert N.), Hopper, J. L. (John L.), Howell, A. (Anthony), Jakimovska, M. (Milena), Jakubowska, A. (Anna), John, E. M. (Esther M.), Jones, M. E. (Michael E.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kauppila, S. (Saila), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Ko, Y.-D. (Yon-Dschun), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Kruger, U. (Ute), Kubelka-Sabit, K. (Katerina), Kurian, A. W. (Allison W.), Kyriacou, K. (Kyriacos), Lambrechts, D. (Diether), Lee, D. G. (Derrick G.), Lindblom, A. (Annika), Linet, M. (Martha), Lissowska, J. (Jolanta), Llaneza, A. (Ana), Lo, W.-Y. (Wing-Yee), MacInnis, R. J. (Robert J.), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Margolin, S. (Sara), Martinez, M. E. (Maria Elena), McLean, C. (Catriona), Meindl, A. (Alfons), Menon, U. (Usha), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Nodora, J. (Jesse), Offit, K. (Kenneth), Olsson, H. (Hakan), Orr, N. (Nick), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa, V), Peto, J. (Julian), Pita, G. (Guillermo), Plaseska-Karanfilska, D. (Dijana), Prentice, R. (Ross), Punie, K. (Kevin), Pylkas, K. (Katri), Radice, P. (Paolo), Rennert, G. (Gad), Romero, A. (Atocha), Ruediger, T. (Thomas), Saloustros, E. (Emmanouil), Sampson, S. (Sarah), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Schoemaker, M. J. (Minouk J.), Schottker, B. (Ben), Sherman, M. E. (Mark E.), Shu, X.-O. (Xiao-Ou), Smichkoska, S. (Snezhana), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Torres, D. (Diana), Troester, M. A. (Melissa A.), Vachon, C. M. (Celine M.), van Deurzen, C. H. (Carolien H. M.), van Veen, E. M. (Elke M.), Wagner, P. (Philippe), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Wesseling, J. (Jelle), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Zheng, W. (Wei), Couch, F. J. (Fergus J.), Simard, J. (Jacques), Kraft, P. (Peter), Easton, D. F. (Douglas F.), Pharoah, P. D. (Paul D. P.), Schmidt, M. K. (Marjanka K.), Garcia-Closas, M. (Montserrat), and Chatterjee, N. (Nilanjan)
Abstract: Background: Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. Methods: Among 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes. Results: Eighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions. Conclusion: This report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
Published: 2022

2. Rare germline copy number variants (CNVs) and breast cancer risk

Author: Dennis, J. (Joe), Tyrer, J. P. (Jonathan P.), Walker, L. C. (Logan C.), Michailidou, K. (Kyriaki), Dorling, L. (Leila), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Freeman, L. E. (Laura E. Beane), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Brenner, H. (Hermann), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chenevix-Trench, G. (Georgia), Clarke, C. L. (Christine L.), N. C. (NBCS Collaborators), Collee, J. M. (J. Margriet), C. C. (CTS Consortium), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Devilee, P. (Peter), Dörk, T. (Thilo), Dossus, L. (Laure), Eliassen, A. H. (A. Heather), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Fletcher, O. (Olivia), Flyger, H. (Henrik), Fritschi, L. (Lin), Gabrielson, M. (Marike), Gago-Dominguez, M. (Manuela), Garcia-Closas, M. (Montserrat), Giles, G. G. (Graham G.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hollestelle, A. (Antoinette), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Howell, A. (Anthony), A. I. (ABCTB Investigators), k. I. (kConFab/AOCS Investigators), Jager, A. (Agnes), Jakubowska, A. (Anna), John, E. M. (Esther M.), Johnson, N. (Nichola), Jones, M. E. (Michael E.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Ko, Y.-D. (Yon-Dschun), Kosma, V.-M. (Veli-Matti), Koutros, S. (Stella), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kubelka-Sabit, K. (Katerina), Kurian, A. W. (Allison W.), Lacey, J. V. (James, V), Lambrechts, D. (Diether), Larson, N. L. (Nicole L.), Linet, M. (Martha), Ogrodniczak, A. (Alicja), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Mavroudis, D. (Dimitrios), Milne, R. L. (Roger L.), Muranen, T. A. (Taru A.), Murphy, R. A. (Rachel A.), Nevanlinna, H. (Heli), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Park-Simon, T.-W. (Tjoung-Won), Perou, C. M. (Charles M.), Peterlongo, P. (Paolo), Plaseska-Karanfilska, D. (Dijana), Pylkas, K. (Katri), Rennert, G. (Gad), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Shibli, R. (Rana), Smeets, A. (Ann), Soucy, P. (Penny), Southey, M. C. (Melissa C.), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Taylor, J. A. (Jack A.), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Vachon, C. M. (Celine M.), Wendt, C. (Camilla), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Zheng, W. (Wei), Ziogas, A. (Argyrios), Simard, J. (Jacques), Dunning, A. M. (Alison M.), Pharoah, P. D. (Paul D. P.), Easton, D. F. (Douglas F.), Dennis, J. (Joe), Tyrer, J. P. (Jonathan P.), Walker, L. C. (Logan C.), Michailidou, K. (Kyriaki), Dorling, L. (Leila), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Freeman, L. E. (Laura E. Beane), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Brenner, H. (Hermann), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chenevix-Trench, G. (Georgia), Clarke, C. L. (Christine L.), N. C. (NBCS Collaborators), Collee, J. M. (J. Margriet), C. C. (CTS Consortium), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Devilee, P. (Peter), Dörk, T. (Thilo), Dossus, L. (Laure), Eliassen, A. H. (A. Heather), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Fletcher, O. (Olivia), Flyger, H. (Henrik), Fritschi, L. (Lin), Gabrielson, M. (Marike), Gago-Dominguez, M. (Manuela), Garcia-Closas, M. (Montserrat), Giles, G. G. (Graham G.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hollestelle, A. (Antoinette), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Howell, A. (Anthony), A. I. (ABCTB Investigators), k. I. (kConFab/AOCS Investigators), Jager, A. (Agnes), Jakubowska, A. (Anna), John, E. M. (Esther M.), Johnson, N. (Nichola), Jones, M. E. (Michael E.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Ko, Y.-D. (Yon-Dschun), Kosma, V.-M. (Veli-Matti), Koutros, S. (Stella), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kubelka-Sabit, K. (Katerina), Kurian, A. W. (Allison W.), Lacey, J. V. (James, V), Lambrechts, D. (Diether), Larson, N. L. (Nicole L.), Linet, M. (Martha), Ogrodniczak, A. (Alicja), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Mavroudis, D. (Dimitrios), Milne, R. L. (Roger L.), Muranen, T. A. (Taru A.), Murphy, R. A. (Rachel A.), Nevanlinna, H. (Heli), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Park-Simon, T.-W. (Tjoung-Won), Perou, C. M. (Charles M.), Peterlongo, P. (Paolo), Plaseska-Karanfilska, D. (Dijana), Pylkas, K. (Katri), Rennert, G. (Gad), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Shibli, R. (Rana), Smeets, A. (Ann), Soucy, P. (Penny), Southey, M. C. (Melissa C.), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Taylor, J. A. (Jack A.), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Vachon, C. M. (Celine M.), Wendt, C. (Camilla), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Zheng, W. (Wei), Ziogas, A. (Argyrios), Simard, J. (Jacques), Dunning, A. M. (Alison M.), Pharoah, P. D. (Paul D. P.), and Easton, D. F. (Douglas F.)
Abstract: Germline copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Gene burden tests detected the strongest association for deletions in BRCA1 (P = 3.7E-18). Nine other genes were associated with a p-value < 0.01 including known susceptibility genes CHEK2 (P = 0.0008), ATM (P = 0.002) and BRCA2 (P = 0.008). Outside the known genes we detected associations with p-values < 0.001 for either overall or subtype-specific breast cancer at nine deletion regions and four duplication regions. Three of the deletion regions were in established common susceptibility loci. To the best of our knowledge, this is the first genome-wide analysis of rare CNVs in a large breast cancer case-control dataset. We detected associations with exonic deletions in established breast cancer susceptibility genes. We also detected suggestive associations with non-coding CNVs in known and novel loci with large effects sizes. Larger sample sizes will be required to reach robust levels of statistical significance.
Published: 2022

3. CYP3A7*1C allele:linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Author: Johnson, N. (Nichola), Maguire, S. (Sarah), Morra, A. (Anna), Kapoor, P. M. (Pooja Middha), Tomczyk, K. (Katarzyna), Jones, M. E. (Michael E.), Schoemaker, M. J. (Minouk J.), Gilham, C. (Clare), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Augustinsson, A. (Annelie), Baynes, C. (Caroline), Freeman, L. E. (Laura E. Beane), Beckmann, M. W. (Matthias W.), Benitez, J. (Javier), Bermisheva, M. (Marina), Blomqvist, C. (Carl), Boeckx, B. (Bram), Bogdanova, N. V. (Natalia V.), Bojesen, S. E. (Stig E.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Burwinkel, B. (Barbara), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Clarke, C. L. (Christine L.), Conroy, D. M. (Don M.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Doerk, T. (Thilo), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Floris, G. (Giuseppe), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Closas, M. (Montserrat), Gaudet, M. M. (Mia M.), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Harrington, P. A. (Patricia A.), Hart, S. N. (Steven N.), Hooning, M. J. (Maartje J.), Hopper, J. L. (John L.), Howell, A. (Anthony), Hunter, D. J. (David J.), Jager, A. (Agnes), Jakubowska, A. (Anna), John, E. M. (Esther M.), Kaaks, R. (Rudolf), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Kosma, V.-M. (Veli-Matti), Koutros, S. (Stella), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kurian, A. W. (Allison W.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Linet, M. (Martha), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martens, J. W. (John W. M.), Mavroudis, D. (Dimitrios), Mayes, R. (Rebecca), Meindl, A. (Alfons), Milne, R. L. (Roger L.), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Obi, N. (Nadia), Olshan, A. F. (Andrew F.), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Orban, E. (Ester), Park-Simon, T.-W. (Tjoung-Won), Peterlongo, P. (Paolo), Plaseska-Karanfilska, D. (Dijana), Pylkäs, K. (Katri), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Ruddy, K. J. (Kathryn J.), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Scott, C. (Christopher), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Smichkoska, S. (Snezhana), Sohn, C. (Christof), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stone, J. (Jennifer), Tamimi, R. M. (Rulla M.), Taylor, J. A. (Jack A.), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Vachon, C. M. (Celine M.), van Veen, E. M. (Elke M.), Wang, S. S. (Sophia S.), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Wildiers, H. (Hans), Winqvist, R. (Robert), Wolk, A. (Alicja), Zheng, W. (Wei), Ziogas, A. (Argyrios), Dunning, A. M. (Alison M.), Pharoah, P. D. (Paul D. P.), Easton, D. F. (Douglas F.), Howie, A. F. (A. Forbes), Peto, J. (Julian), dos-Santos-Silva, I. (Isabel), Swerdlow, A. J. (Anthony J.), Chang-Claude, J. (Jenny), Schmidt, M. K. (Marjanka K.), Orr, N. (Nick), and Fletcher, O. (Olivia)
Abstract: Background: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Methods: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Results: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (−49.2%, 95% CI −56.1% to −41.1%, P = 3.1 × 10⁻¹⁸); in follow-up analyses, rs45446698-C was also associated with lower progesterone (−26.7%, 95% CI −39.4% to −11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82–0.91, P = 6.9 × 10⁻¹⁸). Conclusions: The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.
Published: 2021

4. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Author: Coignard, J. (Juliette), Lush, M. (Michael), Beesley, J. (Jonathan), O’Mara, T.A. (Tracy A.), Dennis, J. (Joe), Tyrer, J.P. (Jonathan P.), Barnes, D. (Daniel), McGuffog, L. (Lesley), Leslie, G. (Goska), Bolla, M.K. (Manjeet K.), Adank, M.A. (Muriel), Agata, S. (Simona), Ahearn, T. (Thomas), Aittomäki, K. (Kristiina), Andrulis, I.L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Arnold, N. (Norbert), Aronson, K.J. (Kristan J.), Arun, B.K. (Banu), Augustinsson, A. (Annelie), Azzollini, J., Barrowdale, D. (Daniel), Baynes, C. (Caroline), Becher, H. (Heko), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Białkowska, K. (Katarzyna), Blomqvist, C. (Carl), Bojesen, S.E. (Stig), Bonnani, B. (Bernardo), Borg, Å. (Åke), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Burwinkel, B. (Barbara), Buys, S.S. (Saundra S.), Caldes, T. (Trinidad), Caligo, M.A. (Maria A.), Campa, D. (Daniele), Carter, B.D. (Brian D.), Castelao, J.E. (Jose ), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen J.), Chung, W.K. (Wendy K.), Claes, K.B.M. (Kathleen B. M.), Clarke, C.L. (Christine L.), Bertrand, O. (Ophélie), Caputo, S. (Sandrine), Dupré, A. (Anaïs), Le Mentec, M. (Marine), Belotti, M. (Muriel), Birot, A.-M. (Anne-Marie), Buecher, B. (Bruno), Fourme, E. (Emmanuelle), Gauthier-Villars, M. (Marion), Golmard, L. (Lisa), Houdayer, C. (Claude), Moncoutier, V. (Virginie), de Pauw, A. (Antoine), Saule, C. (Claire), Sinilnikova, O. (Olga), Mazoyer, S. (Sylvie), Damiola, F. (Francesca), Barjhoux, L. (Laure), Verny-Pierre, C. (Carole), Léone, M. (Mélanie), Boutry-Kryza, N. (N.), Calender, A. (Alain), Giraud, S. (Sophie), Caron, O. (Olivier), Guillaud-Bataille, M. (Marine), Bressac-de Paillerets, B. (Brigitte), Bignon, Y.-J. (Yves-Jean), Uhrhammer, N. (Nancy), Lasset, C. (Christine), Bonadona, V. (Valérie), Berthet, P. (Pascaline), Vaur, D. (Dominique), Castera, L. (Laurent), Noguchi, T. (Tetsuro), Popovici, C. (Cornel), Sobol, H. (Hagay), Bourdon, V. (Violaine), Remenieras, A. (Audrey), Nogues, C. (Catherine), Coupier, I. (Isabelle), Pujol, P. (Pascal), Dumont, A. (Aurélie), Révillion, F. (Françoise), Adenis, C. (Claude), Muller, D.W. (Danièle), Barouk-Simonet, E. (Emmanuelle), Bonnet, F. (Françoise), Bubien, V. (Virginie), Sevenet, N. (Nicolas), Longy, M. (Michel), Toulas, C. (Christine), Guimbaud, R. (Rosine), Gladieff, L. (Laurence), Feillel, V. (Viviane), Leroux, D. (Dominique), Dreyfus, H. (Hélène), Rebischung, C. (Christine), Peysselon, M. (Magalie), Coron, F. (Fanny), Faivre, L. (Laurence), Baurand, A. (Amandine), Jacquot, C. (Caroline), Bertolone, G. (Geoffrey), Lizard, S. (Sarab), Prieur, F. (Fabienne), Lebrun, M. (Marine), Kientz, C. (Caroline), Ferrer, S.F., Mari, V. (Véronique), Vénat-Bouvet, L. (Laurence), Delnatte, C. (Capucine), Bézieau, S. (Stéphane), Mortemousque, I. (Isabelle), Coulet, F. (Florence), Colas, C. (Chrystelle), Soubrier, F. (Florent), Warcoin, M. (Mathilde), Sokolowska, J. (Johanna), Bronner, M. (Myriam), Collonge-Rame, M.-A., Damette, A. (Alexandre), Gesta, P. (Paul), Lallaoui, H. (Hakima), Chiesa, J. (Jean), Molina-Gomes, D. (Denise), Ingster, O. (Olivier), Gregory, H. (Helen), Miedzybrodzka, Z. (Zosia), Morrison, P.J. (Patrick J.), Ong, K.-R. (Kai-ren), Donaldson, A. (Alan), Rogers, M.T. (Mark), Kennedy, M.J. (M. John), Porteous, M.E. (Mary), Brewer, C. (Carole), Davidson, R. (Rosemarie), Izatt, L. (Louise), Brady, A. (A.), Barwell, J. (Julian), Adlard, J.W. (Julian), Foo, C. (Claire), Lalloo, F. (Fiona), Side, L.E. (Lucy E.), Eason, J. (Jacqueline), Henderson, A. (Alex), Walker, L. (Lisa), Eeles, R. (Rosalind), Cook, J. (Jackie), Snape, K. (Katie), Eccles, D. (Diana), Murray, A. (Alexandra), McCann, E. (Emma), Collée, J.M. (J. Margriet), Conroy, D.M. (Don M.), Czene, K. (Kamila), Daly, M.B. (Mary B.), Devilee, P. (Peter), Diez, O. (Orland), Ding, Y.C. (Yuan Chun), Domchek, S.M. (Susan), Dörk, T. (Thilo), Santos Silva, I. (Isabel) dos, Dunning, A.M. (Alison M.), Dwek, M. (Miriam), Eccles, D.M. (Diana M.), Eliassen, A.H. (A. Heather), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D.G. (D. Gareth), Fasching, P.A. (Peter), Flyger, H. (Henrik), Fostira, F. (Florentia), Friedman, E. (Eitan), Fritschi, L. (Lin), Frost, D. (Debra), Gago-Dominguez, M. (Manuela), Gapstur, S.M. (Susan M.), Garber, J. (Judy), Garcia-Barberan, V. (Vanesa), García-Closas, M. (Montserrat), García-Sáenz, J.A. (José A.), Gaudet, M.M. (Mia M.), Gayther, S.A. (Simon), Gehrig, A. (Andrea), Georgoulias, V. (Vassilios), Giles, G.G. (Graham G.), Godwin, A.K. (Andrew K.), Goldberg, M.S. (Mark), Radice, P. (Paolo), González-Neira, A. (Anna), Greene, M.H. (Mark H.), Guénel, P. (Pascal), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C.A. (Christopher), Håkansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Harrington, P.A. (Patricia A.), Hart, S.N. (Steven N.), He, W. (Wei), Hogervorst, F.B.L. (Frans B. L.), Hollestelle, A. (Antoinette), Hopper, J.L. (John), Horcasitas, D.J. (Darling J.), Hulick, P.J. (Peter J.), Hunter, D.J. (David J.), Imyanitov, E.N. (Evgeny), Fox, S.B. (Stephen), Campbell, I. (Ian), Spurdle, A. (Amanda), Webb, P. (Penny), De Fazio, A. (Anna), Tassell, M. (Margaret), Kirk, J. (Judy), Lindeman, G.J. (Geoffrey), Price, M. (Melanie), Southey, M.C. (Melissa), Milne, R.L. (Roger), Deb, S. (Sid), Bowtell, D. (David), Hout, A.H. (Annemarie) van der, Ouweland, A.M.W. (Ans) van den, Mensenkamp, A.R. (Arjen R.), Deurzen, C.H.M. (Carolien) van, Kets, C.M. (Marleen), Seynaeve, C.M. (Caroline), van Asperen, C.J. (Christi J.), Aalfs, C.M. (Cora), Gómez Garcia, E.B. (Encarna B.), Leeuwen, F.E. (Flora) van, Bock, G.H. (Geertruida) de, Meijers-Heijboer, E.J. (Hanne), Obdeijn, A.I.M. (Inge-Marie), Gille, J.J.P. (J. J.P.), Oosterwijk, J.C. (Jan), Wijnen, J.T. (Juul), Kolk, L.E. (Lizet) van der, Hooning, M.J. (Maartje), Ausems, M.G.E.M. (Margreet), Mourits, M.J. (Marjan), Blok, M.J. (Marinus J.), Rookus, M.A. (Matti), van der Luijt, R.B. (Rob B.), Cronenburg, T.C.T.E.F. van, Pol, C. (Carmen) van der, Russell, N.S. (Nicola), Siesling, S. (Sabine), Overbeek, L.I.H. (Lucy), Wijnands, R. (R.), Lange, J.L. (J.) de, Clarke, C. (Christine), Graham, D. (Dinny), Sachchithananthan, M. (Mythily), Marsh, D. (Deborah), Scott, R.J. (Rodney), Baxter, R. (Robert), Yip, D. (Desmond), Carpenter, T.A. (Adrian), Davis, A. (Alison), Pathmanathan, N. (Nirmala), Simpson, P. (Peter), Jager, A. (Agnes), Jakubowska, A. (Anna), James, M. (Margaret), Jensen, U.B. (Uffe Birk), John, E.M. (Esther), Jones, M.E. (Michael E.), Kaaks, R. (Rudolf), Kapoor, P.M. (Pooja Middha), Karlan, B.Y. (Beth), Keeman, R. (Renske), Khusnutdinova, E.K. (Elza), Kiiski, J.I. (Johanna I.), Ko, Y.-D. (Yon-Dschun), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kurian, A.W. (Allison W.), Laitman, Y. (Yael), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lester, J. (Jenny), Lesueur, F. (Fabienne), Lindstrom, T. (Tricia), Lopez-Fernández, A. (Adria), Loud, J.T. (Jennifer T.), Luccarini, C. (Craig), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martens, J.W.M. (John), Mebirouk, N. (Noura), Meindl, A. (Alfons), Miller, A. (Austin), Milne, R.L. (Roger L.), Montagna, M. (Marco), Nathanson, K.L. (Katherine), Floris, O.A.M., Nevanlinna, H. (Heli), Nielsen, F.C. (Finn C.), O’Brien, K.M. (Katie M.), Olopade, O.I. (Olofunmilayo), Olson, J.E. (Janet), Olsson, H. (Håkan), Osorio, A. (Ana), Ottini, L. (Laura), Park-Simon, T.-W. (Tjoung-Won), Parsons, M. (Marilyn), Pedersen, I.S. (Inge Sokilde), Peshkin, B. (Beth), Peterlongo, P. (Paolo), Peto, J. (Julian), Pharoah, P.D.P. (Paul), Phillips, K.-A. (Kelly-Anne), Polley, E.C. (Eric C.), Poppe, B. (Bruce), Presneau, N. (Nadege), Pujana, M.A. (Miquel Angel), Punie, K. (Kevin), Rantala, J. (Johanna), Rashid, M.U. (Muhammad), Rennert, G. (Gad), Rennert, H.S. (Hedy S.), Robson, M. (Mark), Romero, A. (Atocha), Rossing, M. (Maria), Saloustros, E. (Emmanouil), Sandler, D.P. (Dale P.), Santella, R.M. (Regina), Scheuner, M.T. (Maren T.), Schmidt, M.K. (Marjanka K.), Schmidt, G. (Gunnar), Scott, C. (Christopher), Sharma, P. (Priyanka), Soucy, P. (Penny), Southey, M.C. (Melissa C.), Spinelli, J.J. (John J.), Steinsnyder, Z. (Zoe), Stone, J. (Jennifer), Stoppa-Lyonnet, D. (Dominique), Swerdlow, A.J. (Anthony ), Tamimi, R. (Rulla), Tapper, W.J. (William J.), Taylor, J.A. (Jack A.), Terry, M.B. (Mary Beth), Teulé, A. (Alex), Thull, D.L. (Darcy L.), Tischkowitz, M. (Marc), Toland, A.E. (Amanda), Torres, D. (Diana), Trainer, A.H. (Alison H.), Truong, T. (Thérèse), Tung, N. (Nadine), Vachon, C. (Celine), Vega, A. (Ana), Joseph, V. (Vijai), Wang, Q. (Qin), Wappenschmidt, B. (Barbara), Weinberg, C.R. (Clarice R.), Weitzel, J.N. (Jeffrey), Wendt, C. (Camilla), Wolk, K. (Kerstin), Yadav, S. (Siddhartha), Yang, X.R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Ziogas, A. (Argyrios), Zorn, K.K. (Kristin K.), Park, S.K. (Sue K.), Thomassen, M. (Mads), Offit, K. (Kenneth), Schmutzler, R.K. (Rita), Couch, F.J. (Fergus), Simard, J. (Jacques), Chenevix-Trench, G. (Georgia), Adamo, P. (Pio) d', Andrieu, N. (Nadine), Antoniou, A.C. (Antonis C.), Coignard, J. (Juliette), Lush, M. (Michael), Beesley, J. (Jonathan), O’Mara, T.A. (Tracy A.), Dennis, J. (Joe), Tyrer, J.P. (Jonathan P.), Barnes, D. (Daniel), McGuffog, L. (Lesley), Leslie, G. (Goska), Bolla, M.K. (Manjeet K.), Adank, M.A. (Muriel), Agata, S. (Simona), Ahearn, T. (Thomas), Aittomäki, K. (Kristiina), Andrulis, I.L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Arnold, N. (Norbert), Aronson, K.J. (Kristan J.), Arun, B.K. (Banu), Augustinsson, A. (Annelie), Azzollini, J., Barrowdale, D. (Daniel), Baynes, C. (Caroline), Becher, H. (Heko), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Białkowska, K. (Katarzyna), Blomqvist, C. (Carl), Bojesen, S.E. (Stig), Bonnani, B. (Bernardo), Borg, Å. (Åke), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Burwinkel, B. (Barbara), Buys, S.S. (Saundra S.), Caldes, T. (Trinidad), Caligo, M.A. (Maria A.), Campa, D. (Daniele), Carter, B.D. (Brian D.), Castelao, J.E. (Jose ), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen J.), Chung, W.K. (Wendy K.), Claes, K.B.M. (Kathleen B. M.), Clarke, C.L. (Christine L.), Bertrand, O. (Ophélie), Caputo, S. (Sandrine), Dupré, A. (Anaïs), Le Mentec, M. (Marine), Belotti, M. (Muriel), Birot, A.-M. (Anne-Marie), Buecher, B. (Bruno), Fourme, E. (Emmanuelle), Gauthier-Villars, M. (Marion), Golmard, L. (Lisa), Houdayer, C. (Claude), Moncoutier, V. (Virginie), de Pauw, A. (Antoine), Saule, C. (Claire), Sinilnikova, O. (Olga), Mazoyer, S. (Sylvie), Damiola, F. (Francesca), Barjhoux, L. (Laure), Verny-Pierre, C. (Carole), Léone, M. (Mélanie), Boutry-Kryza, N. (N.), Calender, A. (Alain), Giraud, S. (Sophie), Caron, O. (Olivier), Guillaud-Bataille, M. (Marine), Bressac-de Paillerets, B. (Brigitte), Bignon, Y.-J. (Yves-Jean), Uhrhammer, N. (Nancy), Lasset, C. (Christine), Bonadona, V. (Valérie), Berthet, P. (Pascaline), Vaur, D. (Dominique), Castera, L. (Laurent), Noguchi, T. (Tetsuro), Popovici, C. (Cornel), Sobol, H. (Hagay), Bourdon, V. (Violaine), Remenieras, A. (Audrey), Nogues, C. (Catherine), Coupier, I. (Isabelle), Pujol, P. (Pascal), Dumont, A. (Aurélie), Révillion, F. (Françoise), Adenis, C. (Claude), Muller, D.W. (Danièle), Barouk-Simonet, E. (Emmanuelle), Bonnet, F. (Françoise), Bubien, V. (Virginie), Sevenet, N. (Nicolas), Longy, M. (Michel), Toulas, C. (Christine), Guimbaud, R. (Rosine), Gladieff, L. (Laurence), Feillel, V. (Viviane), Leroux, D. (Dominique), Dreyfus, H. (Hélène), Rebischung, C. (Christine), Peysselon, M. (Magalie), Coron, F. (Fanny), Faivre, L. (Laurence), Baurand, A. (Amandine), Jacquot, C. (Caroline), Bertolone, G. (Geoffrey), Lizard, S. (Sarab), Prieur, F. (Fabienne), Lebrun, M. (Marine), Kientz, C. (Caroline), Ferrer, S.F., Mari, V. (Véronique), Vénat-Bouvet, L. (Laurence), Delnatte, C. (Capucine), Bézieau, S. (Stéphane), Mortemousque, I. (Isabelle), Coulet, F. (Florence), Colas, C. (Chrystelle), Soubrier, F. (Florent), Warcoin, M. (Mathilde), Sokolowska, J. (Johanna), Bronner, M. (Myriam), Collonge-Rame, M.-A., Damette, A. (Alexandre), Gesta, P. (Paul), Lallaoui, H. (Hakima), Chiesa, J. (Jean), Molina-Gomes, D. (Denise), Ingster, O. (Olivier), Gregory, H. (Helen), Miedzybrodzka, Z. (Zosia), Morrison, P.J. (Patrick J.), Ong, K.-R. (Kai-ren), Donaldson, A. (Alan), Rogers, M.T. (Mark), Kennedy, M.J. (M. John), Porteous, M.E. (Mary), Brewer, C. (Carole), Davidson, R. (Rosemarie), Izatt, L. (Louise), Brady, A. (A.), Barwell, J. (Julian), Adlard, J.W. (Julian), Foo, C. (Claire), Lalloo, F. (Fiona), Side, L.E. (Lucy E.), Eason, J. (Jacqueline), Henderson, A. (Alex), Walker, L. (Lisa), Eeles, R. (Rosalind), Cook, J. (Jackie), Snape, K. (Katie), Eccles, D. (Diana), Murray, A. (Alexandra), McCann, E. (Emma), Collée, J.M. (J. Margriet), Conroy, D.M. (Don M.), Czene, K. (Kamila), Daly, M.B. (Mary B.), Devilee, P. (Peter), Diez, O. (Orland), Ding, Y.C. (Yuan Chun), Domchek, S.M. (Susan), Dörk, T. (Thilo), Santos Silva, I. (Isabel) dos, Dunning, A.M. (Alison M.), Dwek, M. (Miriam), Eccles, D.M. (Diana M.), Eliassen, A.H. (A. Heather), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D.G. (D. Gareth), Fasching, P.A. (Peter), Flyger, H. (Henrik), Fostira, F. (Florentia), Friedman, E. (Eitan), Fritschi, L. (Lin), Frost, D. (Debra), Gago-Dominguez, M. (Manuela), Gapstur, S.M. (Susan M.), Garber, J. (Judy), Garcia-Barberan, V. (Vanesa), García-Closas, M. (Montserrat), García-Sáenz, J.A. (José A.), Gaudet, M.M. (Mia M.), Gayther, S.A. (Simon), Gehrig, A. (Andrea), Georgoulias, V. (Vassilios), Giles, G.G. (Graham G.), Godwin, A.K. (Andrew K.), Goldberg, M.S. (Mark), Radice, P. (Paolo), González-Neira, A. (Anna), Greene, M.H. (Mark H.), Guénel, P. (Pascal), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C.A. (Christopher), Håkansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Harrington, P.A. (Patricia A.), Hart, S.N. (Steven N.), He, W. (Wei), Hogervorst, F.B.L. (Frans B. L.), Hollestelle, A. (Antoinette), Hopper, J.L. (John), Horcasitas, D.J. (Darling J.), Hulick, P.J. (Peter J.), Hunter, D.J. (David J.), Imyanitov, E.N. (Evgeny), Fox, S.B. (Stephen), Campbell, I. (Ian), Spurdle, A. (Amanda), Webb, P. (Penny), De Fazio, A. (Anna), Tassell, M. (Margaret), Kirk, J. (Judy), Lindeman, G.J. (Geoffrey), Price, M. (Melanie), Southey, M.C. (Melissa), Milne, R.L. (Roger), Deb, S. (Sid), Bowtell, D. (David), Hout, A.H. (Annemarie) van der, Ouweland, A.M.W. (Ans) van den, Mensenkamp, A.R. (Arjen R.), Deurzen, C.H.M. (Carolien) van, Kets, C.M. (Marleen), Seynaeve, C.M. (Caroline), van Asperen, C.J. (Christi J.), Aalfs, C.M. (Cora), Gómez Garcia, E.B. (Encarna B.), Leeuwen, F.E. (Flora) van, Bock, G.H. (Geertruida) de, Meijers-Heijboer, E.J. (Hanne), Obdeijn, A.I.M. (Inge-Marie), Gille, J.J.P. (J. J.P.), Oosterwijk, J.C. (Jan), Wijnen, J.T. (Juul), Kolk, L.E. (Lizet) van der, Hooning, M.J. (Maartje), Ausems, M.G.E.M. (Margreet), Mourits, M.J. (Marjan), Blok, M.J. (Marinus J.), Rookus, M.A. (Matti), van der Luijt, R.B. (Rob B.), Cronenburg, T.C.T.E.F. van, Pol, C. (Carmen) van der, Russell, N.S. (Nicola), Siesling, S. (Sabine), Overbeek, L.I.H. (Lucy), Wijnands, R. (R.), Lange, J.L. (J.) de, Clarke, C. (Christine), Graham, D. (Dinny), Sachchithananthan, M. (Mythily), Marsh, D. (Deborah), Scott, R.J. (Rodney), Baxter, R. (Robert), Yip, D. (Desmond), Carpenter, T.A. (Adrian), Davis, A. (Alison), Pathmanathan, N. (Nirmala), Simpson, P. (Peter), Jager, A. (Agnes), Jakubowska, A. (Anna), James, M. (Margaret), Jensen, U.B. (Uffe Birk), John, E.M. (Esther), Jones, M.E. (Michael E.), Kaaks, R. (Rudolf), Kapoor, P.M. (Pooja Middha), Karlan, B.Y. (Beth), Keeman, R. (Renske), Khusnutdinova, E.K. (Elza), Kiiski, J.I. (Johanna I.), Ko, Y.-D. (Yon-Dschun), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kurian, A.W. (Allison W.), Laitman, Y. (Yael), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lester, J. (Jenny), Lesueur, F. (Fabienne), Lindstrom, T. (Tricia), Lopez-Fernández, A. (Adria), Loud, J.T. (Jennifer T.), Luccarini, C. (Craig), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martens, J.W.M. (John), Mebirouk, N. (Noura), Meindl, A. (Alfons), Miller, A. (Austin), Milne, R.L. (Roger L.), Montagna, M. (Marco), Nathanson, K.L. (Katherine), Floris, O.A.M., Nevanlinna, H. (Heli), Nielsen, F.C. (Finn C.), O’Brien, K.M. (Katie M.), Olopade, O.I. (Olofunmilayo), Olson, J.E. (Janet), Olsson, H. (Håkan), Osorio, A. (Ana), Ottini, L. (Laura), Park-Simon, T.-W. (Tjoung-Won), Parsons, M. (Marilyn), Pedersen, I.S. (Inge Sokilde), Peshkin, B. (Beth), Peterlongo, P. (Paolo), Peto, J. (Julian), Pharoah, P.D.P. (Paul), Phillips, K.-A. (Kelly-Anne), Polley, E.C. (Eric C.), Poppe, B. (Bruce), Presneau, N. (Nadege), Pujana, M.A. (Miquel Angel), Punie, K. (Kevin), Rantala, J. (Johanna), Rashid, M.U. (Muhammad), Rennert, G. (Gad), Rennert, H.S. (Hedy S.), Robson, M. (Mark), Romero, A. (Atocha), Rossing, M. (Maria), Saloustros, E. (Emmanouil), Sandler, D.P. (Dale P.), Santella, R.M. (Regina), Scheuner, M.T. (Maren T.), Schmidt, M.K. (Marjanka K.), Schmidt, G. (Gunnar), Scott, C. (Christopher), Sharma, P. (Priyanka), Soucy, P. (Penny), Southey, M.C. (Melissa C.), Spinelli, J.J. (John J.), Steinsnyder, Z. (Zoe), Stone, J. (Jennifer), Stoppa-Lyonnet, D. (Dominique), Swerdlow, A.J. (Anthony ), Tamimi, R. (Rulla), Tapper, W.J. (William J.), Taylor, J.A. (Jack A.), Terry, M.B. (Mary Beth), Teulé, A. (Alex), Thull, D.L. (Darcy L.), Tischkowitz, M. (Marc), Toland, A.E. (Amanda), Torres, D. (Diana), Trainer, A.H. (Alison H.), Truong, T. (Thérèse), Tung, N. (Nadine), Vachon, C. (Celine), Vega, A. (Ana), Joseph, V. (Vijai), Wang, Q. (Qin), Wappenschmidt, B. (Barbara), Weinberg, C.R. (Clarice R.), Weitzel, J.N. (Jeffrey), Wendt, C. (Camilla), Wolk, K. (Kerstin), Yadav, S. (Siddhartha), Yang, X.R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Ziogas, A. (Argyrios), Zorn, K.K. (Kristin K.), Park, S.K. (Sue K.), Thomassen, M. (Mads), Offit, K. (Kenneth), Schmutzler, R.K. (Rita), Couch, F.J. (Fergus), Simard, J. (Jacques), Chenevix-Trench, G. (Georgia), Adamo, P. (Pio) d', Andrieu, N. (Nadine), and Antoniou, A.C. (Antonis C.)
Abstract: Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.
Published: 2021
Full Text: View/download PDF

5. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Author: Baxter, J. S. (Joseph S.), Johnson, N. (Nichola), Tomczyk, K. (Katarzyna), Gillespie, A. (Andrea), Maguire, S. (Sarah), Brough, R. (Rachel), Fachal, L. (Laura), Michailidou, K. (Kyriaki), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Augustinsson, A. (Annelie), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Brenner, H. (Hermann), Brucker, S. Y. (Sara Y.), Cai, Q. (Qiuyin), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chan, T. L. (Tsun L.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Choi, J.-Y. (Ji-Yeob), Clarke, C. L. (Christine L.), Collaborators, N. (Nbcs), Colonna, S. (Sarah), Conroy, D. M. (Don M.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Doerk, T. (Thilo), Dossus, L. (Laure), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Gao, C. (Chi), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Ghoussaini, M. (Maya), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Guendert, M. (Melanie), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hamann, U. (Ute), Hartman, M. (Mikael), Hatse, S. (Sigrid), Hauke, J. (Jan), Hollestelle, A. (Antoinette), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Hou, M.-F. (Ming-Feng), Ito, H. (Hidemi), Iwasaki, M. (Motoki), Jager, A. (Agnes), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Joseph, V. (Vijai), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kang, D. (Daehee), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kim, S.-W. (Sung-Won), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kubelka-Sabit, K. (Katerina), Kurian, A. W. (Allison W.), Kwong, A. (Ava), Lacey, J. V. (James, V), Lambrechts, D. (Diether), Larson, N. L. (Nicole L.), Larsson, S. C. (Susanna C.), Le Marchand, L. (Loic), Lejbkowicz, F. (Flavio), Li, J. (Jingmei), Long, J. (Jirong), Lophatananon, A. (Artitaya), LubiNski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Matsuo, K. (Keitaro), Mavroudis, D. (Dimitrios), Mayes, R. (Rebecca), Menon, U. (Usha), Milne, R. L. (Roger L.), Taib, N. A. (Nur Aishah Mohd), Muir, K. (Kenneth), Muranen, T. A. (Taru A.), Murphy, R. A. (Rachel A.), Nevanlinna, H. (Heli), O'Brien, K. M. (Katie M.), Offit, K. (Kenneth), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Park, S. K. (Sue K.), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa, V), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Presneau, N. (Nadege), Pylkäs, K. (Katri), Rack, B. (Brigitte), Rennert, G. (Gad), Romero, A. (Atocha), Ruebner, M. (Matthias), Ruediger, T. (Thomas), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Schoemaker, M. J. (Minouk J.), Shah, M. (Mitul), Shen, C.-Y. (Chen-Yang), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Southey, M. C. (Melissa C.), Stone, J. (Jennifer), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Teo, S. H. (Soo Hwang), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Toland, A. E. (Amanda E.), Tomlinson, I. (Ian), Truong, T. (Therese), Tseng, C.-C. (Chiu-Chen), Untch, M. (Michael), Vachon, C. M. (Celine M.), van den Ouweland, A. M. (Ans M. W.), Wang, S. S. (Sophia S.), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Winham, S. J. (Stacey J.), Winqvist, R. (Robert), Wolk, A. (Alicja), Wu, A. H. (Anna H.), Yamaji, T. (Taiki), Zheng, W. (Wei), Ziogas, A. (Argyrios), Pharoah, P. D. (Paul D. P.), Dunning, A. M. (Alison M.), Easton, D. F. (Douglas F.), Pettitt, S. J. (Stephen J.), Lord, C. J. (Christopher J.), Haider, S. (Syed), Orr, N. (Nick), Fletcher, O. (Olivia), Baxter, J. S. (Joseph S.), Johnson, N. (Nichola), Tomczyk, K. (Katarzyna), Gillespie, A. (Andrea), Maguire, S. (Sarah), Brough, R. (Rachel), Fachal, L. (Laura), Michailidou, K. (Kyriaki), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Augustinsson, A. (Annelie), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Brenner, H. (Hermann), Brucker, S. Y. (Sara Y.), Cai, Q. (Qiuyin), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chan, T. L. (Tsun L.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Choi, J.-Y. (Ji-Yeob), Clarke, C. L. (Christine L.), Collaborators, N. (Nbcs), Colonna, S. (Sarah), Conroy, D. M. (Don M.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Doerk, T. (Thilo), Dossus, L. (Laure), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Gao, C. (Chi), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Ghoussaini, M. (Maya), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Guendert, M. (Melanie), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hamann, U. (Ute), Hartman, M. (Mikael), Hatse, S. (Sigrid), Hauke, J. (Jan), Hollestelle, A. (Antoinette), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Hou, M.-F. (Ming-Feng), Ito, H. (Hidemi), Iwasaki, M. (Motoki), Jager, A. (Agnes), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Joseph, V. (Vijai), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kang, D. (Daehee), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kim, S.-W. (Sung-Won), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kubelka-Sabit, K. (Katerina), Kurian, A. W. (Allison W.), Kwong, A. (Ava), Lacey, J. V. (James, V), Lambrechts, D. (Diether), Larson, N. L. (Nicole L.), Larsson, S. C. (Susanna C.), Le Marchand, L. (Loic), Lejbkowicz, F. (Flavio), Li, J. (Jingmei), Long, J. (Jirong), Lophatananon, A. (Artitaya), LubiNski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Matsuo, K. (Keitaro), Mavroudis, D. (Dimitrios), Mayes, R. (Rebecca), Menon, U. (Usha), Milne, R. L. (Roger L.), Taib, N. A. (Nur Aishah Mohd), Muir, K. (Kenneth), Muranen, T. A. (Taru A.), Murphy, R. A. (Rachel A.), Nevanlinna, H. (Heli), O'Brien, K. M. (Katie M.), Offit, K. (Kenneth), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Park, S. K. (Sue K.), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa, V), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Presneau, N. (Nadege), Pylkäs, K. (Katri), Rack, B. (Brigitte), Rennert, G. (Gad), Romero, A. (Atocha), Ruebner, M. (Matthias), Ruediger, T. (Thomas), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Schoemaker, M. J. (Minouk J.), Shah, M. (Mitul), Shen, C.-Y. (Chen-Yang), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Southey, M. C. (Melissa C.), Stone, J. (Jennifer), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Teo, S. H. (Soo Hwang), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Toland, A. E. (Amanda E.), Tomlinson, I. (Ian), Truong, T. (Therese), Tseng, C.-C. (Chiu-Chen), Untch, M. (Michael), Vachon, C. M. (Celine M.), van den Ouweland, A. M. (Ans M. W.), Wang, S. S. (Sophia S.), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Winham, S. J. (Stacey J.), Winqvist, R. (Robert), Wolk, A. (Alicja), Wu, A. H. (Anna H.), Yamaji, T. (Taiki), Zheng, W. (Wei), Ziogas, A. (Argyrios), Pharoah, P. D. (Paul D. P.), Dunning, A. M. (Alison M.), Easton, D. F. (Douglas F.), Pettitt, S. J. (Stephen J.), Lord, C. J. (Christopher J.), Haider, S. (Syed), Orr, N. (Nick), and Fletcher, O. (Olivia)
Abstract: A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter at both signals (30- to 40-fold increased expression by the putative regulatory element at signal 2, 2- to 3-fold by the putative regulatory element at signal 3). We further identified one of the five credible causal variants at signal 2, a 1.4 kb deletion (esv3594306), as the likely causal variant; the deletion allele of this variant was associated with an average additional increase in IGFBP5 expression of 1.3-fold (MCF-7) and 2.2-fold (T-47D). We propose a model in which the deletion allele of esv3594306 juxtaposes two transcription factor binding regions (annotated by estrogen receptor alpha ChIP-seq peaks) to generate a single extended regulatory element. This regulatory element increases cell-type-specific expression of the tumor suppressor gene IGFBP5 and, thereby, reduces risk of estrogen receptor-positive breast cancer (odds ratio = 0.77, 95% CI 0.74–0.81, p = 3.1 × 10−31).
Published: 2021

6. Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

Author: Escala-Garcia, M. (Maria), Canisius, S. (Sander), Keeman, R. (Renske), Beesley, J. (Jonathan), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Augustinsson, A. (Annelie), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Bermisheva, M. (Marina), Bojesen, S. E. (Stig E.), Bolla, M. K. (Manjeet K.), Brenner, H. (Hermann), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Couch, F. J. (Fergus J.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Dennis, J. (Joe), Devilee, P. (Peter), Dork, T. (Thilo), Dunning, A. M. (Alison M.), Easton, D. F. (Douglas F.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Fasching, P. A. (Peter A.), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Geisler, J. (Juergen), Giles, G. G. (Graham G.), Grip, M. (Mervi), Guendert, M. (Melanie), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hartikainen, J. M. (Jaana M.), Heemskerk-Gerritsen, B. A. (Bernadette A. M.), Hollestelle, A. (Antoinette), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Hunter, D. J. (David J.), Jacot, W. (William), Jakubowska, A. (Anna), John, E. M. (Esther M.), Jung, A. Y. (Audrey Y.), Kaaks, R. (Rudolf), Khusnutdinova, E. (Elza), Koppert, L. B. (Linetta B.), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kurian, A. W. (Allison W.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lindblom, A. (Annika), Luben, R. N. (Robert N.), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Margolin, S. (Sara), Mavroudis, D. (Dimitrios), Muranen, T. A. (Taru A.), Nevanlinna, H. (Heli), Olshan, A. F. (Andrew F.), Olsson, H. (Hakan), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa V.), Peterlongo, P. (Paolo), Pharoah, P. D. (Paul D. P.), Punie, K. (Kevin), Radice, P. (Paolo), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Romero, A. (Atocha), Roylance, R. (Rebecca), Ruediger, T. (Thomas), Ruebner, M. (Matthias), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Schoemaker, M. J. (Minouk J.), Scott, C. (Christopher), Southey, M. C. (Melissa C.), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Teras, L. R. (Lauren R.), Thomas, E. (Emilie), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Vachon, C. M. (Celine M.), Wang, Q. (Qin), Winqvist, R. (Robert), Wolk, A. (Alicja), Ziogas, A. (Argyrios), Michailidou, K. (Kyriaki), Chenevix-Trench, G. (Georgia), Bachelot, T. (Thomas), Schmidt, M. K. (Marjanka K.), Escala-Garcia, M. (Maria), Canisius, S. (Sander), Keeman, R. (Renske), Beesley, J. (Jonathan), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Augustinsson, A. (Annelie), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Bermisheva, M. (Marina), Bojesen, S. E. (Stig E.), Bolla, M. K. (Manjeet K.), Brenner, H. (Hermann), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Couch, F. J. (Fergus J.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Dennis, J. (Joe), Devilee, P. (Peter), Dork, T. (Thilo), Dunning, A. M. (Alison M.), Easton, D. F. (Douglas F.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Fasching, P. A. (Peter A.), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Geisler, J. (Juergen), Giles, G. G. (Graham G.), Grip, M. (Mervi), Guendert, M. (Melanie), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hartikainen, J. M. (Jaana M.), Heemskerk-Gerritsen, B. A. (Bernadette A. M.), Hollestelle, A. (Antoinette), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Hunter, D. J. (David J.), Jacot, W. (William), Jakubowska, A. (Anna), John, E. M. (Esther M.), Jung, A. Y. (Audrey Y.), Kaaks, R. (Rudolf), Khusnutdinova, E. (Elza), Koppert, L. B. (Linetta B.), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kurian, A. W. (Allison W.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lindblom, A. (Annika), Luben, R. N. (Robert N.), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Margolin, S. (Sara), Mavroudis, D. (Dimitrios), Muranen, T. A. (Taru A.), Nevanlinna, H. (Heli), Olshan, A. F. (Andrew F.), Olsson, H. (Hakan), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa V.), Peterlongo, P. (Paolo), Pharoah, P. D. (Paul D. P.), Punie, K. (Kevin), Radice, P. (Paolo), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Romero, A. (Atocha), Roylance, R. (Rebecca), Ruediger, T. (Thomas), Ruebner, M. (Matthias), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Schoemaker, M. J. (Minouk J.), Scott, C. (Christopher), Southey, M. C. (Melissa C.), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Teras, L. R. (Lauren R.), Thomas, E. (Emilie), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Vachon, C. M. (Celine M.), Wang, Q. (Qin), Winqvist, R. (Robert), Wolk, A. (Alicja), Ziogas, A. (Argyrios), Michailidou, K. (Kyriaki), Chenevix-Trench, G. (Georgia), Bachelot, T. (Thomas), and Schmidt, M. K. (Marjanka K.)
Abstract: Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment. In this analysis, we studied the associations between germline variants and breast cancer survival for patients with distant metastases at primary breast cancer diagnosis. We used data from the Breast Cancer Association Consortium (BCAC) including 1062 women of European ancestry with metastatic breast cancer, 606 of whom died of breast cancer. We identified two germline variants on chromosome 1, rs138569520 and rs146023652, significantly associated with breast cancer-specific survival (P = 3.19 × 10−8 and 4.42 × 10−8). In silico analysis suggested a potential regulatory effect of the variants on the nearby target genes SDE2 and H3F3A. However, the variants showed no evidence of association in a smaller replication dataset. The validation dataset was obtained from the SNPs to Risk of Metastasis (StoRM) study and included 293 patients with metastatic primary breast cancer at diagnosis. Ultimately, larger replication studies are needed to confirm the identified associations.
Published: 2021

7. Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Author: Park, H. A. (Hanla A.), Neumeyer, S. (Sonja), Michailidou, K. (Kyriaki), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Augustinsson, A. (Annelie), Baten, A. (Adinda), Freeman, L. E. (Laura E. Beane), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brucker, S. Y. (Sara Y.), Burwinkel, B. (Barbara), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Clarke, C. L. (Christine L.), Conroy, D. M. (Don M.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Dork, T. (Thilo), Dos-Santos-Silva, I. (Isabel), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Flyger, H. (Henrik), Fritschi, L. (Lin), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), Giles, G. G. (Graham G.), Glendon, G. (Gord), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Grip, M. (Mervi), Guenel, P. (Pascal), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Han, S. (Sileny), Harkness, E. F. (Elaine F.), Hart, S. N. (Steven N.), He, W. (Wei), Heemskerk-Gerritsen, B. A. (Bernadette A. M.), Hopper, J. L. (John L.), Hunter, D. J. (David J.), Jager, A. (Agnes), Jakubowska, A. (Anna), John, E. M. (Esther M.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kapoor, P. M. (Pooja Middha), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Koppert, L. B. (Linetta B.), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Kurian, A. W. (Allison W.), Lacey, J. (James), Lambrechts, D. (Diether), LeMarchand, L. (Loic), Lo, W.-Y. (Wing-Yee), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Margolin, S. (Sara), ElenaMartinez, M. (Maria), Mavroudis, D. (Dimitrios), Meindl, A. (Alfons), Menon, U. (Usha), Milne, R. L. (Roger L.), Muranen, T. A. (Taru A.), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Nordestgaard, B. G. (Borge G.), Offit, K. (Kenneth), Olshan, A. F. (Andrew F.), Olsson, H. (Hakan), Park-Simon, T.-W. (Tjoung-Won), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Presneau, N. (Nadege), Radice, P. (Paolo), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Romero, A. (Atocha), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Schoemaker, M. J. (Minouk J.), Schwentner, L. (Lukas), Scott, C. (Christopher), Shah, M. (Mitul), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Smeets, A. (Ann), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stevens, V. (Victoria), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Terry, M. B. (Mary Beth), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Vachon, C. M. (Celine M.), van Veen, E. M. (Elke M.), Vijai, J. (Joseph), Wang, S. (Sophia), Wendt, C. (Camilla), Winqvist, R. (Robert), Wolk, A. (Alicja), Ziogas, A. (Argyrios), Dunning, A. M. (Alison M.), Pharoah, P. D. (Paul D. P.), Easton, D. F. (Douglas F.), Zheng, W. (Wei), Kraft, P. (Peter), Chang-Claude, J. (Jenny), Park, H. A. (Hanla A.), Neumeyer, S. (Sonja), Michailidou, K. (Kyriaki), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Augustinsson, A. (Annelie), Baten, A. (Adinda), Freeman, L. E. (Laura E. Beane), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brucker, S. Y. (Sara Y.), Burwinkel, B. (Barbara), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Clarke, C. L. (Christine L.), Conroy, D. M. (Don M.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Dork, T. (Thilo), Dos-Santos-Silva, I. (Isabel), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Flyger, H. (Henrik), Fritschi, L. (Lin), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), Giles, G. G. (Graham G.), Glendon, G. (Gord), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Grip, M. (Mervi), Guenel, P. (Pascal), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Han, S. (Sileny), Harkness, E. F. (Elaine F.), Hart, S. N. (Steven N.), He, W. (Wei), Heemskerk-Gerritsen, B. A. (Bernadette A. M.), Hopper, J. L. (John L.), Hunter, D. J. (David J.), Jager, A. (Agnes), Jakubowska, A. (Anna), John, E. M. (Esther M.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kapoor, P. M. (Pooja Middha), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Koppert, L. B. (Linetta B.), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Kurian, A. W. (Allison W.), Lacey, J. (James), Lambrechts, D. (Diether), LeMarchand, L. (Loic), Lo, W.-Y. (Wing-Yee), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Margolin, S. (Sara), ElenaMartinez, M. (Maria), Mavroudis, D. (Dimitrios), Meindl, A. (Alfons), Menon, U. (Usha), Milne, R. L. (Roger L.), Muranen, T. A. (Taru A.), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Nordestgaard, B. G. (Borge G.), Offit, K. (Kenneth), Olshan, A. F. (Andrew F.), Olsson, H. (Hakan), Park-Simon, T.-W. (Tjoung-Won), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Presneau, N. (Nadege), Radice, P. (Paolo), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Romero, A. (Atocha), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Schoemaker, M. J. (Minouk J.), Schwentner, L. (Lukas), Scott, C. (Christopher), Shah, M. (Mitul), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Smeets, A. (Ann), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stevens, V. (Victoria), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Terry, M. B. (Mary Beth), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Vachon, C. M. (Celine M.), van Veen, E. M. (Elke M.), Vijai, J. (Joseph), Wang, S. (Sophia), Wendt, C. (Camilla), Winqvist, R. (Robert), Wolk, A. (Alicja), Ziogas, A. (Argyrios), Dunning, A. M. (Alison M.), Pharoah, P. D. (Paul D. P.), Easton, D. F. (Douglas F.), Zheng, W. (Wei), Kraft, P. (Peter), and Chang-Claude, J. (Jenny)
Abstract: Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07–1.30, P = 0.11 × 10⁻²), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78–1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusions: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.
Published: 2021

8. Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Author: Morra, A. (Anna), Escala-Garcia, M. (Maria), Beesley, J. (Jonathan), Keeman, R. (Renske), Canisius, S. (Sander), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Auer, P. L. (Paul L.), Augustinsson, A. (Annelie), Freeman, L. E. (Laura E. Beane), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Bojesen, S. E. (Stig E.), Bolla, M. K. (Manjeet K.), Brenner, H. (Hermann), Bruening, T. (Thomas), Buys, S. S. (Saundra S.), Caan, B. (Bette), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Cheng, T. D. (Ting-Yuan David), Clarke, C. L. (Christine L.), Colonna, S. V. (Sarah, V), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Dennis, J. (Joe), Dork, T. (Thilo), Dossus, L. (Laure), Dunning, A. M. (Alison M.), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Flyger, H. (Henrik), Fritschi, L. (Lin), Gago-Dominguez, M. (Manuela), Garcia-Saenz, J. A. (Jose A.), Giles, G. G. (Graham G.), Grip, M. (Mervi), Guenel, P. (Pascal), Guendert, M. (Melanie), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hart, S. N. (Steven N.), Hartikainen, J. M. (Jaana M.), Hartmann, A. (Arndt), He, W. (Wei), Hooning, M. J. (Maartje J.), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Howell, A. (Anthony), Hunter, D. J. (David J.), Jager, A. (Agnes), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Jung, A. Y. (Audrey Y.), Kaaks, R. (Rudolf), Keupers, M. (Machteld), Kitahara, C. M. (Cari M.), Koutros, S. (Stella), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kurian, A. W. (Allison W.), Lacey, J. V. (James, V), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lindblom, A. (Annika), Linet, M. (Martha), Luben, R. N. (Robert N.), Lush, M. (Michael), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Margolin, S. (Sara), Martens, J. W. (John W. M.), Martinez, M. E. (Maria Elena), Mavroudis, D. (Dimitrios), Michailidou, K. (Kyriaki), Milne, R. L. (Roger L.), Mulligan, A. M. (Anna Marie), Muranen, T. A. (Taru A.), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Olshan, A. F. (Andrew F.), Olsson, H. (Hakan), Orr, N. (Nick), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa, V), Peissel, B. (Bernard), Peterlongo, P. (Paolo), Plaseska-Karanfilska, D. (Dijana), Prajzendanc, K. (Karolina), Prentice, R. (Ross), Presneau, N. (Nadege), Rack, B. (Brigitte), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Rhenius, V. (Valerie), Romero, A. (Atocha), Roylance, R. (Rebecca), Lubinski, J. (Jan), Ruebner, M. (Matthias), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Scott, C. (Christopher), Shah, M. (Mitul), Smichkoska, S. (Snezhana), Southey, M. C. (Melissa C.), Stone, J. (Jennifer), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Vachon, C. M. (Celine M.), Wang, Q. (Qin), Hurson, A. N. (Amber N.), Winqvist, R. (Robert), Wolk, A. (Alicja), Ziogas, A. (Argyrios), Brauch, H. (Hiltrud), Garcia-Closas, M. (Montserrat), Pharoah, P. D. (Paul D. P.), Easton, D. F. (Douglas F.), Chenevix-Trench, G. (Georgia), Schmidt, M. K. (Marjanka K.), Morra, A. (Anna), Escala-Garcia, M. (Maria), Beesley, J. (Jonathan), Keeman, R. (Renske), Canisius, S. (Sander), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Auer, P. L. (Paul L.), Augustinsson, A. (Annelie), Freeman, L. E. (Laura E. Beane), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Bojesen, S. E. (Stig E.), Bolla, M. K. (Manjeet K.), Brenner, H. (Hermann), Bruening, T. (Thomas), Buys, S. S. (Saundra S.), Caan, B. (Bette), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Cheng, T. D. (Ting-Yuan David), Clarke, C. L. (Christine L.), Colonna, S. V. (Sarah, V), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Dennis, J. (Joe), Dork, T. (Thilo), Dossus, L. (Laure), Dunning, A. M. (Alison M.), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Flyger, H. (Henrik), Fritschi, L. (Lin), Gago-Dominguez, M. (Manuela), Garcia-Saenz, J. A. (Jose A.), Giles, G. G. (Graham G.), Grip, M. (Mervi), Guenel, P. (Pascal), Guendert, M. (Melanie), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hart, S. N. (Steven N.), Hartikainen, J. M. (Jaana M.), Hartmann, A. (Arndt), He, W. (Wei), Hooning, M. J. (Maartje J.), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Howell, A. (Anthony), Hunter, D. J. (David J.), Jager, A. (Agnes), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Jung, A. Y. (Audrey Y.), Kaaks, R. (Rudolf), Keupers, M. (Machteld), Kitahara, C. M. (Cari M.), Koutros, S. (Stella), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kurian, A. W. (Allison W.), Lacey, J. V. (James, V), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lindblom, A. (Annika), Linet, M. (Martha), Luben, R. N. (Robert N.), Lush, M. (Michael), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Margolin, S. (Sara), Martens, J. W. (John W. M.), Martinez, M. E. (Maria Elena), Mavroudis, D. (Dimitrios), Michailidou, K. (Kyriaki), Milne, R. L. (Roger L.), Mulligan, A. M. (Anna Marie), Muranen, T. A. (Taru A.), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Olshan, A. F. (Andrew F.), Olsson, H. (Hakan), Orr, N. (Nick), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa, V), Peissel, B. (Bernard), Peterlongo, P. (Paolo), Plaseska-Karanfilska, D. (Dijana), Prajzendanc, K. (Karolina), Prentice, R. (Ross), Presneau, N. (Nadege), Rack, B. (Brigitte), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Rhenius, V. (Valerie), Romero, A. (Atocha), Roylance, R. (Rebecca), Lubinski, J. (Jan), Ruebner, M. (Matthias), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Scott, C. (Christopher), Shah, M. (Mitul), Smichkoska, S. (Snezhana), Southey, M. C. (Melissa C.), Stone, J. (Jennifer), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Vachon, C. M. (Celine M.), Wang, Q. (Qin), Hurson, A. N. (Amber N.), Winqvist, R. (Robert), Wolk, A. (Alicja), Ziogas, A. (Argyrios), Brauch, H. (Hiltrud), Garcia-Closas, M. (Montserrat), Pharoah, P. D. (Paul D. P.), Easton, D. F. (Douglas F.), Chenevix-Trench, G. (Georgia), and Schmidt, M. K. (Marjanka K.)
Abstract: Background: Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients. Methods: We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of European ancestry from the Breast Cancer Association Consortium, including 7531 breast cancer-specific deaths over a median follow-up of 8.1 years. Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. We assessed the probability of these associations being true positives via the Bayesian false discovery probability (BFDP & 0.15). Results: Evidence of associations with breast cancer-specific survival was observed in three patient subgroups, with variant rs5934618 in patients with grade 3 tumors (15-year-hazard ratio (HR) [95% confidence interval (CI)] 1.32 [1.20, 1.45], P = 1.4E−08, BFDP = 0.01, per G allele); variant rs4679741 in patients with ER-positive tumors treated with endocrine therapy (15-year-HR [95% CI] 1.18 [1.11, 1.26], P = 1.6E−07, BFDP = 0.09, per G allele); variants rs1106333 (15-year-HR [95% CI] 1.68 [1.39,2.03], P = 5.6E−08, BFDP = 0.12, per A allele) and rs78754389 (5-year-HR [95% CI] 1.79 [1.46,2.20], P = 1.7E−08, BFDP = 0.07, per A allele), in patients with ER-negative tumors treated with chemotherapy. Conclusions: We found evidence of four loci associated with breast cancer-specific survival within three patient subgroups. There was limited evidence for the existence of associations in other patient subgroups. However, the power for many subgroups is limited due to the low number of events. Even so, our results suggest that the impact of common germline genetic varia
Published: 2021

9. Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Author: Zhang, H. (Haoyu), Ahearn, T. U. (Thomas U.), Lecarpentier, J. (Julie), Barnes, D. (Daniel), Beesley, J. (Jonathan), Qi, G. (Guanghao), Hang, X. (Xia), O'Mara, T. A. (Tracy A.), Zhao, N. (Ni), Bolla, M. K. (Manjeet K.), Dunning, A. M. (Alison M.), Dennis, J. (Joe), Wang, Q. (Qin), Abu Ful, Z. (Zumuruda), Aittomaki, K. (Kristiina), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Arun, B. K. (Banu K.), Auer, P. L. (Paul L.), Azzollini, J. (Jacopo), Barrowdale, D. (Daniel), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bialkowska, K. (Katarzyna), Blanco, A. (Ana), Blomqvist, C. (Carl), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Bonanni, B. (Bernardo), Bondavalli, D. (Davide), Borg, A. (Ake), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Briceno, I. (Ignacio), Broeks, A. (Annegien), Brucker, S. Y. (Sara Y.), Bruening, T. (Thomas), Burwinkel, B. (Barbara), Buys, S. S. (Saundra S.), Byers, H. (Helen), Caldes, T. (Trinidad), Caligo, M. A. (Maria A.), Calvello, M. (Mariarosaria), Campa, D. (Daniele), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Christiaens, M. (Melissa), Christiansen, H. (Hans), Chung, W. K. (Wendy K.), Claes, K. B. (Kathleen B. M.), Clarke, C. L. (Christine L.), Cornelissen, S. (Sten), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Diez, O. (Orland), Domchek, S. M. (Susan M.), Doerk, T. (Thilo), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Foretova, L. (Lenka), Fostira, F. (Florentia), Friedman, E. (Eitan), Frost, D. (Debra), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garber, J. (Judy), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), Gayther, S. A. (Simon A.), Giles, G. G. (Graham G.), Godwin, A. K. (Andrew K.), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Greene, M. H. (Mark H.), Gronwald, J. (Jacek), Guenel, P. (Pascal), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hake, C. R. (Christopher R.), Hall, P. (Per), Hamann, U. (Ute), Harkness, E. F. (Elaine F.), Heemskerk-Gerritsen, B. A. (Bernadette A. M.), Hillemanns, P. (Peter), Hogervorst, F. B. (Frans B. L.), Holleczek, B. (Bernd), Hollestelle, A. (Antoinette), Hooning, M. J. (Maartje J.), Hoover, R. N. (Robert N.), Hopper, J. L. (John L.), Howell, A. (Anthony), Huebner, H. (Hanna), Hulick, P. J. (Peter J.), Imyanitov, E. N. (Evgeny N.), Isaacs, C. (Claudine), Izatt, L. (Louise), Jager, A. (Agnes), Jakimovska, M. (Milena), Jakubowska, A. (Anna), James, P. (Paul), Janavicius, R. (Ramunas), Janni, W. (Wolfgang), John, E. M. (Esther M.), Jones, M. E. (Michael E.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kapoor, P. M. (Pooja Middha), Karlan, B. Y. (Beth Y.), Keeman, R. (Renske), Khan, S. (Sofia), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Ko, Y.-D. (Yon-Dschun), Konstantopoulou, I. (Irene), Koppert, L. B. (Linetta B.), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Laenkholm, A.-V. (Anne-Vibeke), Lambrechts, D. (Diether), Larsson, S. C. (Susanna C.), Laurent-Puig, P. (Pierre), Lazaro, C. (Conxi), Lazarova, E. (Emilija), Lejbkowicz, F. (Flavio), Leslie, G. (Goska), Lesueur, F. (Fabienne), Lindblom, A. (Annika), Lissowska, J. (Jolanta), Lo, W.-Y. (Wing-Yee), Loud, J. T. (Jennifer T.), Lubinski, J. (Jan), Lukomska, A. (Alicja), Maclnnis, R. J. (Robert J.), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martinez, M. E. (Maria Elena), Matricardi, L. (Laura), McGuffog, L. (Lesley), McLean, C. (Catriona), Mebirouk, N. (Noura), Meindl, A. (Alfons), Menon, U. (Usha), Miller, A. (Austin), Mingazheva, E. (Elvira), Montagna, M. (Marco), Mulligan, A. M. (Anna Marie), Mulot, C. (Claire), Muranen, T. A. (Taru A.), Nathanson, K. L. (Katherine L.), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Neven, P. (Patrick), Newman, W. G. (William G.), Nielsens, F. C. (Finn C.), Nikitina-Zake, L. (Liene), Nodora, J. (Jesse), Offit, K. (Kenneth), Olah, E. (Edith), Olopade, O. I. (Olufunmilayo, I), Olsson, H. (Hakan), Orr, N. (Nick), Papi, L. (Laura), Papp, J. (Janos), Park-Simon, T.-W. (Tjoung-Won), Parsons, M. T. (Michael T.), Peissel, B. (Bernard), Peixoto, A. (Ana), Peshkin, B. (Beth), Peterlongo, P. (Paolo), Peto, J. (Julian), Phillips, K.-A. (Kelly-Anne), Piedmonte, M. (Marion), Plaseska-Karanfilska, D. (Dijana), Prajzendanc, K. (Karolina), Prentice, R. (Ross), Prokofyeva, D. (Darya), Rack, B. (Brigitte), Radice, P. (Paolo), Ramus, S. J. (Susan J.), Rantala, J. (Johanna), Rashid, M. U. (Muhammad U.), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Risch, H. A. (Harvey A.), Romero, A. (Atocha), Rookus, M. A. (Matti A.), Ruebner, M. (Matthias), Ruediger, T. (Thomas), Saloustros, E. (Emmanouil), Sampson, S. (Sarah), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Scheuner, M. T. (Maren T.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Schoemaker, M. J. (Minouk J.), Schoettker, B. (Ben), Schuermann, P. (Peter), Senter, L. (Leigha), Sharma, P. (Priyanka), Sherman, M. E. (Mark E.), Shu, X.-O. (Xiao-Ou), Singer, C. F. (Christian F.), Smichkoska, S. (Snezhana), Soucy, P. (Penny), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stone, J. (Jennifer), Stoppa-Lyonnet, D. (Dominique), Swerdlow, A. J. (Anthony J.), Szabo, C. I. (Csilla, I), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Teixeira, M. R. (Manuel R.), Terry, M. (MaryBeth), Thomassen, M. (Mads), Thull, D. L. (Darcy L.), Tischkowitz, M. (Marc), Toland, A. E. (Amanda E.), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Torres, D. (Diana), Troester, M. A. (Melissa A.), Truong, T. (Therese), Tung, N. (Nadine), Untch, M. (Michael), Vachon, C. M. (Celine M.), van den Ouweland, A. M. (Ans M. W.), van der Kolk, L. E. (Lizet E.), van Veen, E. M. (Elke M.), vanRensburg, E. J. (Elizabeth J.), Vega, A. (Ana), Wappenschmidt, B. (Barbara), Weinberg, C. R. (Clarice R.), Weitzel, J. N. (Jeffrey N.), Wildiers, H. (Hans), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Zorn, K. K. (Kristin K.), Milne, R. L. (Roger L.), Kraft, P. (Peter), Simard, J. (Jacques), Pharoah, P. D. (Paul D. P.), Michailidou, K. (Kyriaki), Antoniou, A. C. (Antonis C.), Schmidt, M. K. (Marjanka K.), Chenevix-Trench, G. (Georgia), Easton, D. F. (Douglas F.), Chatterjee, N. (Nilanjan), and Garcia-Closas, M. (Montserrat)
Abstract: Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade. We identified 32 novel susceptibility loci (P
Published: 2020

10. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis

Author: Saberi Hosnijeh, F. (Fatemeh), Casabonne, D. (Delphine), Nieters, A. (Alexandra), Solans, M. (Marta), Naudin, S. (Sabine), Ferrari, P. (Pietro), Mckay, J.D. (James D.), Benavente, Y. (Yolanda), Weiderpass, E. (Elisabete), Freisling, H. (Heinz), Severi, G. (Gianluca), Boutron Ruault, M.-C. (Marie-Christine), Besson, C. (Caroline), Agnoli, C. (Claudia), Masala, G. (Giovanna), Sacerdote, C. (Carlotta), Tumino, R. (Rosario), Huerta, J.M. (José María), Amiano, P. (Pilar), Rodriguez-Barranco, M. (Miguel), Bonet, C. (Catalina), Barricarte, A. (Aurelio), Christakoudi, S. (Sofia), Knuppel, A. (Anika), Bueno-de-Mesquita, B. (Bas), Schulze, M.B. (Matthias), Kaaks, R. (Rudolf), Canzian, F. (Federico), Späth, F. (Florentin), Jerkeman, M. (Mats), Rylander, C. (Charlotta), Tjønneland, A. (Anne), Olsen, A. (Anja), Borch, K.B. (Kristin Benjaminsen), Vermeulen, R. (Roel), Saberi Hosnijeh, F. (Fatemeh), Casabonne, D. (Delphine), Nieters, A. (Alexandra), Solans, M. (Marta), Naudin, S. (Sabine), Ferrari, P. (Pietro), Mckay, J.D. (James D.), Benavente, Y. (Yolanda), Weiderpass, E. (Elisabete), Freisling, H. (Heinz), Severi, G. (Gianluca), Boutron Ruault, M.-C. (Marie-Christine), Besson, C. (Caroline), Agnoli, C. (Claudia), Masala, G. (Giovanna), Sacerdote, C. (Carlotta), Tumino, R. (Rosario), Huerta, J.M. (José María), Amiano, P. (Pilar), Rodriguez-Barranco, M. (Miguel), Bonet, C. (Catalina), Barricarte, A. (Aurelio), Christakoudi, S. (Sofia), Knuppel, A. (Anika), Bueno-de-Mesquita, B. (Bas), Schulze, M.B. (Matthias), Kaaks, R. (Rudolf), Canzian, F. (Federico), Späth, F. (Florentin), Jerkeman, M. (Mats), Rylander, C. (Charlotta), Tjønneland, A. (Anne), Olsen, A. (Anja), Borch, K.B. (Kristin Benjaminsen), and Vermeulen, R. (Roel)
Abstract: To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual a
Published: 2020
Full Text: View/download PDF

11. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Author: Saberi Hosnijeh, F. (Fatemeh), Kolijn, P.M. (Pieter M.), Casabonne, D. (Delphine), Nieters, A. (Alexandra), Solans, M. (Marta), Naudin, S. (Sabine), Ferrari, P. (Pietro), Mckay, J.D. (James D.), Weiderpass, E. (Elisabete), Perduca, V. (Vittorio), Besson, C. (Caroline), Mancini, F.R. (Francesca Romana), Masala, G. (Giovanna), Krogh, V. (Vittorio), Ricceri, F. (Fulvio), Huerta, J.M. (José M.), Petrova, D. (Dafina), Sala, N. (Núria), Trichopoulou, A. (Antonia), Karakatsani, A. (Anna), La Vecchia, C. (Carlo), Kaaks, R. (Rudolf), Canzian, F. (Federico), Aune, D. (Dagfinn), Boeing, H. (Heiner), Schulze, M.B. (Matthias), Perez-Cornago, A. (Aurora), Langerak, A.W. (Anton), Velden, V.H.J. (Vincent) van der, Vermeulen, R. (Roel), Saberi Hosnijeh, F. (Fatemeh), Kolijn, P.M. (Pieter M.), Casabonne, D. (Delphine), Nieters, A. (Alexandra), Solans, M. (Marta), Naudin, S. (Sabine), Ferrari, P. (Pietro), Mckay, J.D. (James D.), Weiderpass, E. (Elisabete), Perduca, V. (Vittorio), Besson, C. (Caroline), Mancini, F.R. (Francesca Romana), Masala, G. (Giovanna), Krogh, V. (Vittorio), Ricceri, F. (Fulvio), Huerta, J.M. (José M.), Petrova, D. (Dafina), Sala, N. (Núria), Trichopoulou, A. (Antonia), Karakatsani, A. (Anna), La Vecchia, C. (Carlo), Kaaks, R. (Rudolf), Canzian, F. (Federico), Aune, D. (Dagfinn), Boeing, H. (Heiner), Schulze, M.B. (Matthias), Perez-Cornago, A. (Aurora), Langerak, A.W. (Anton), Velden, V.H.J. (Vincent) van der, and Vermeulen, R. (Roel)
Abstract: Sustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL subtypes. Pre-diagnostic serum levels were measured for 517 BCL cases and 525 controls in a nested case–control study. The odds ratios of BCL were 6.2 in the highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2 for sCD27, and 2.6 for CXCL13. Higher levels of all markers were associated with increased risk of chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). Following mutual adjustment for the other immune markers, sCD23 remained associated with all subtypes and CXCL13 with FL and DLBCL. The associations of sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted among cases sampled > 9 years before diagnosis. sCD23 showed a good predictive ability (area under the curve = 0.80) for CLL, in particular among older, male participants. sCD23 and CXCL13 showed a mediating effect between body mass index (positive) and DLBCL risk, while CXCL13 contributed to the association between physical activity (inverse) and DLBCL. Our data suggest a role of B-cell activation in BCL development and a mediating role of the immune system for lifestyle factors.
Published: 2020
Full Text: View/download PDF

12. Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

Author: Liu, J. (Jingjing), Prager-van der Smissen, W.J.C. (Wendy), Collée, J.M. (J Margriet), Bolla, M.K. (Manjeet K.), Wang, Q. (Qin), Michailidou, K. (Kyriaki), Dennis, J. (Joe), Ahearn, T.U. (Thomas U.), Aittomäki, K. (Kristiina), Ambrosone, C.B. (Christine), Andrulis, I.L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N.N. (Natalia N.), Arndt, V. (Volker), Arnold, N. (Norbert), Aronson, K.J. (Kristan J.), Augustinsson, A. (Annelie), Auvinen, P. (Päivi), Becher, H. (Heiko), Beckmann, M.W. (Matthias), Behrens, T.W. (Timothy), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Bogdanova, N.V. (Natalia V.), Bogdanova-Markov, N. (Nadja), Bojesen, S.E. (Stig), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Briceno, I. (Ignacio), Brucker, S.Y. (Sara Y.), Brüning, T. (Thomas), Burwinkel, B. (Barbara), Cai, Q. (Qiuyin), Cai, H. (Hui), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J.E. (Jose ), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen), Choi, J.-Y. (J.), Christiaens, M. (Melissa), Clarke, C. (Christine), Couch, F.J. (Fergus), Czene, K. (Kamila), Daly, M.B. (Mary), Devilee, P. (Peter), Santos Silva, I. (Isabel) dos, Dwek, M. (Miriam), Eccles, D.M. (Diana M.), Eliassen, A.H. (A Heather), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Flyger, H. (Henrik), Fritschi, L. (Lin), Gago-Dominguez, M. (Manuela), Gapstur, S.M. (Susan M.), García-Closas, M. (Montserrat), García-Sáenz, J.A. (José A), Gaudet, M.M. (Mia M.), Giles, G.G. (Graham G.), Goldberg, M.S. (Mark), Radice, P. (Paolo), Guénel, P. (Pascal), Haiman, C.A. (Christopher), Håkansson, N. (Niclas), Hall, P. (Per), Harrington, P.A. (Patricia A.), Hart, S.N. (Steven N.), Hartman, J.M. (Joost), Hillemanns, P. (Peter), Hopper, J.L. (John), Hou, M.-F. (Ming-Feng), Hunter, D.J. (David), Huo, D. (Dezheng), Ito, H. (Hidemi), Iwasaki, M. (Motoki), Jakimovska, M. (Milena), Jakubowska, A. (Anna), John, E.M. (Esther), Kaaks, R. (Rudolf), Kang, D. (Daehee), Keeman, R. (Renske), Khusnutdinova, E.K. (Elza), Kim, S.-W. (Sung-Won), Kraft, P. (Peter), Kristensen, V. (Vessela), Kurian, A.W. (Allison W.), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindblom, A. (Annika), Lophatananon, A. (Artitaya), Luben, R.N. (Robert N.), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Mariapun, S. (Shivaani), Matsuo, K. (Keitaro), Maurer, T. (Tabea), Mavroudis, D. (Dimitris), Meindl, A. (Alfons), Menon, U. (Usha), Milne, R.L. (Roger), Muir, K. (Kenneth), Mulligan, A.-M. (Anna-Marie), Floris, O.A.M., Nevanlinna, H. (Heli), Offit, K. (Kenneth), Olopade, O.I. (Olofunmilayo), Olson, J.E. (Janet), Olsson, H. (Håkan), Orr, N. (Nick), Park, S.K. (Sue K.), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Presneau, N. (Nadege), Rack, B. (Brigitte), Rau-Murthy, R. (Rohini), Rennert, G. (Gad), Rennert, H.S. (Hedy S.), Rhenius, V. (Valerie), Romero, A. (Atocha), Ruebner, M. (Matthias), Saloustros, E. (Emmanouil), Schmutzler, R.K. (Rita), Schneeweiss, A. (Andreas), Scott, C.G. (Christopher G.), Shah, M. (Mitul), Shen, C.-Y. (Chen-Yang), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Sohn, C. (Christof), Southey, M.C. (Melissa), Spinelli, J.J. (John J.), Tamimi, R. (Rulla), Tapper, W.J. (William J.), Teo, S.H. (Soo H.), Terry, M.B. (Mary Beth), Torres, D. (Diana), Truong, T. (Thérèse), Untch, M. (Michael), Vachon, C. (Celine), van Asperen, C.J. (Christi J.), Wolk, K. (Kerstin), Yamaji, T. (Taiki), Zheng, W. (Wei), Ziogas, A. (Argyrios), Ziv, E. (Elad), Torres-Mejía, G. (Gabriela), Dörk, T. (Thilo), Swerdlow, A.J. (Anthony ), Hamann, U. (Ute), Schmidt, M.K. (Marjanka), Dunning, A.M. (Alison M.), Pharoah, P.D.P. (Paul), Adamo, P. (Pio) d', Hooning, M.J. (Maartje J.), Martens, J.W.M. (John), Hollestelle, A. (Antoinette), Liu, J. (Jingjing), Prager-van der Smissen, W.J.C. (Wendy), Collée, J.M. (J Margriet), Bolla, M.K. (Manjeet K.), Wang, Q. (Qin), Michailidou, K. (Kyriaki), Dennis, J. (Joe), Ahearn, T.U. (Thomas U.), Aittomäki, K. (Kristiina), Ambrosone, C.B. (Christine), Andrulis, I.L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N.N. (Natalia N.), Arndt, V. (Volker), Arnold, N. (Norbert), Aronson, K.J. (Kristan J.), Augustinsson, A. (Annelie), Auvinen, P. (Päivi), Becher, H. (Heiko), Beckmann, M.W. (Matthias), Behrens, T.W. (Timothy), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Bogdanova, N.V. (Natalia V.), Bogdanova-Markov, N. (Nadja), Bojesen, S.E. (Stig), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Briceno, I. (Ignacio), Brucker, S.Y. (Sara Y.), Brüning, T. (Thomas), Burwinkel, B. (Barbara), Cai, Q. (Qiuyin), Cai, H. (Hui), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J.E. (Jose ), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen), Choi, J.-Y. (J.), Christiaens, M. (Melissa), Clarke, C. (Christine), Couch, F.J. (Fergus), Czene, K. (Kamila), Daly, M.B. (Mary), Devilee, P. (Peter), Santos Silva, I. (Isabel) dos, Dwek, M. (Miriam), Eccles, D.M. (Diana M.), Eliassen, A.H. (A Heather), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Flyger, H. (Henrik), Fritschi, L. (Lin), Gago-Dominguez, M. (Manuela), Gapstur, S.M. (Susan M.), García-Closas, M. (Montserrat), García-Sáenz, J.A. (José A), Gaudet, M.M. (Mia M.), Giles, G.G. (Graham G.), Goldberg, M.S. (Mark), Radice, P. (Paolo), Guénel, P. (Pascal), Haiman, C.A. (Christopher), Håkansson, N. (Niclas), Hall, P. (Per), Harrington, P.A. (Patricia A.), Hart, S.N. (Steven N.), Hartman, J.M. (Joost), Hillemanns, P. (Peter), Hopper, J.L. (John), Hou, M.-F. (Ming-Feng), Hunter, D.J. (David), Huo, D. (Dezheng), Ito, H. (Hidemi), Iwasaki, M. (Motoki), Jakimovska, M. (Milena), Jakubowska, A. (Anna), John, E.M. (Esther), Kaaks, R. (Rudolf), Kang, D. (Daehee), Keeman, R. (Renske), Khusnutdinova, E.K. (Elza), Kim, S.-W. (Sung-Won), Kraft, P. (Peter), Kristensen, V. (Vessela), Kurian, A.W. (Allison W.), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindblom, A. (Annika), Lophatananon, A. (Artitaya), Luben, R.N. (Robert N.), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Mariapun, S. (Shivaani), Matsuo, K. (Keitaro), Maurer, T. (Tabea), Mavroudis, D. (Dimitris), Meindl, A. (Alfons), Menon, U. (Usha), Milne, R.L. (Roger), Muir, K. (Kenneth), Mulligan, A.-M. (Anna-Marie), Floris, O.A.M., Nevanlinna, H. (Heli), Offit, K. (Kenneth), Olopade, O.I. (Olofunmilayo), Olson, J.E. (Janet), Olsson, H. (Håkan), Orr, N. (Nick), Park, S.K. (Sue K.), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Presneau, N. (Nadege), Rack, B. (Brigitte), Rau-Murthy, R. (Rohini), Rennert, G. (Gad), Rennert, H.S. (Hedy S.), Rhenius, V. (Valerie), Romero, A. (Atocha), Ruebner, M. (Matthias), Saloustros, E. (Emmanouil), Schmutzler, R.K. (Rita), Schneeweiss, A. (Andreas), Scott, C.G. (Christopher G.), Shah, M. (Mitul), Shen, C.-Y. (Chen-Yang), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Sohn, C. (Christof), Southey, M.C. (Melissa), Spinelli, J.J. (John J.), Tamimi, R. (Rulla), Tapper, W.J. (William J.), Teo, S.H. (Soo H.), Terry, M.B. (Mary Beth), Torres, D. (Diana), Truong, T. (Thérèse), Untch, M. (Michael), Vachon, C. (Celine), van Asperen, C.J. (Christi J.), Wolk, K. (Kerstin), Yamaji, T. (Taiki), Zheng, W. (Wei), Ziogas, A. (Argyrios), Ziv, E. (Elad), Torres-Mejía, G. (Gabriela), Dörk, T. (Thilo), Swerdlow, A.J. (Anthony ), Hamann, U. (Ute), Schmidt, M.K. (Marjanka), Dunning, A.M. (Alison M.), Pharoah, P.D.P. (Paul), Adamo, P. (Pio) d', Hooning, M.J. (Maartje J.), Martens, J.W.M. (John), and Hollestelle, A. (Antoinette)
Abstract: In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast cancer cases and 2,327 controls from the Netherlands. Although both recurrent HOXB13 mutations p.G84E and p.R217C were not associated with breast cancer risk, the risk estimation for p.R217C was not very precise. To provide more conclusive evidence regarding the role of HOXB13 in breast cancer susceptibility, we here evaluated the association between HOXB13 mutations and increased breast cancer risk within 81 studies of the international Breast Cancer Association Consortium containing 68,521 invasive breast cancer patients and 54,865 controls. Both HOXB13 p.G84E and p.R217C did not associate with the development of breast cancer in European women, neither in the overall analysis (OR = 1.035, 95% CI = 0.859-1.246, P = 0.718 and OR = 0.798, 95% CI = 0.482-1.322, P = 0.381 respectively), nor in specific high-risk subgroups or breast cancer subtypes. Thus, although involved in breast cancer progression, HOXB13 is not a material breast cancer susceptibility gene.
Published: 2020
Full Text: View/download PDF

13. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Author: Li, C. (Chen), Stoma, S. (Svetlana), Lotta, L.A. (Luca A.), Warner, S. (Sophie), Albrecht, E. (Eva), Allione, A. (Alessandra), Arp, P.P. (Pascal), Broer, L. (Linda), Buxton, J.L. (Jessica L.), Da Silva Couto Alves, A. (Alexessander), Deelen, J. (Joris), Fedko, I.O. (Iryna O.), Gordon, S.D. (Scott D.), Jiang, T. (Tao), Karlsson, R. (Robert), Kerrison, N. (Nicola), Loe, T.K. (Taylor K.), Mangino, M. (Massimo), Milaneschi, Y. (Yuri), Miraglio, B. (Benjamin), Pervjakova, N. (Natalia), Russo, A. (Alessia), Surakka, I. (Ida), Spek, A. (Ashley) van der, Verhoeven, J.E. (Josine E.), Amin, N. (Najaf), Beekman, M. (Marian), Blakemore, A.I. (Alexandra I.), Canzian, F. (Federico), Hamby, S.E. (Stephen E.), Hottenga, J.J. (Jouke Jan), Jones, P.D. (Peter D.), Jousilahti, P. (Pekka), Mägi, R. (Reedik), Medland, S.E. (Sarah), Montgomery, G.W. (Grant), Nyholt, D.R. (Dale), Perola, M. (Markus), Pietilainen, K.H. (Kirsi Hannele), Salomaa, V. (Veikko), Sillanpää, E. (Elina), Suchiman, H.E. (H. Eka), Heemst, D. (Diana) van, Willemsen, G. (Gonneke), Agudo, A. (Antonio), Boeing, H. (Heiner), Boomsma, D.I. (Dorret), Chirlaque, M.D. (M.), Fagherazzi, G. (Guy), Ferrari, P. (Pietro), Franks, P. (Paul), Gieger, C. (Christian), Hagen, K. (Knut), Gunter, M.J. (Marc J.), Hägg, S. (Sara), Hovatta, I. (Iiris), Imaz, L. (Liher), Kaprio, J. (Jaakko), Kaaks, R. (Rudolf), Key, T. (Tim), Krogh, V. (Vittorio), Martin, N.G. (Nicholas), Melander, O. (Olle), Metspalu, A. (Andres), Moreno, C. (Concha), Onland-Moret, N.C. (N. Charlotte), Nilsson, P. (Peter), Ong, K.K. (Ken K.), Overvad, K. (Kim), Palli, D. (Domenico), Panico, S. (Salvatore), Pedersen, N.L. (Nancy), Penninx, B.W.J.H. (Brenda), Quirós, J.R., Jarvelin, M.R. (Marjo Riitta), Rodríguez-Barranco, M. (Miguel), Scott, R.A. (Robert A.), Severi, G. (Gianluca), Slagboom, P.E. (Eline), Spector, T.D. (Timothy), Tjønneland, A. (Anne), Trichopoulou, A. (Antonia), Tumino, R. (Rosario), Uitterlinden, A.G. (André G.), Schouw, Y.T. (Yvonne) van der, Duijn, C.M. (Cornelia) van, Weiderpass, E. (Elisabete), Denchi, E.L. (Eros Lazzerini), Matullo, G., Butterworth, A.S. (Adam S.), Danesh, J. (John), Samani, N.J. (Nilesh), Wareham, N.J. (Nick), Nelson, C.P. (Christopher P.), Langenberg, C. (Claudia), Codd, V. (Veryan), Li, C. (Chen), Stoma, S. (Svetlana), Lotta, L.A. (Luca A.), Warner, S. (Sophie), Albrecht, E. (Eva), Allione, A. (Alessandra), Arp, P.P. (Pascal), Broer, L. (Linda), Buxton, J.L. (Jessica L.), Da Silva Couto Alves, A. (Alexessander), Deelen, J. (Joris), Fedko, I.O. (Iryna O.), Gordon, S.D. (Scott D.), Jiang, T. (Tao), Karlsson, R. (Robert), Kerrison, N. (Nicola), Loe, T.K. (Taylor K.), Mangino, M. (Massimo), Milaneschi, Y. (Yuri), Miraglio, B. (Benjamin), Pervjakova, N. (Natalia), Russo, A. (Alessia), Surakka, I. (Ida), Spek, A. (Ashley) van der, Verhoeven, J.E. (Josine E.), Amin, N. (Najaf), Beekman, M. (Marian), Blakemore, A.I. (Alexandra I.), Canzian, F. (Federico), Hamby, S.E. (Stephen E.), Hottenga, J.J. (Jouke Jan), Jones, P.D. (Peter D.), Jousilahti, P. (Pekka), Mägi, R. (Reedik), Medland, S.E. (Sarah), Montgomery, G.W. (Grant), Nyholt, D.R. (Dale), Perola, M. (Markus), Pietilainen, K.H. (Kirsi Hannele), Salomaa, V. (Veikko), Sillanpää, E. (Elina), Suchiman, H.E. (H. Eka), Heemst, D. (Diana) van, Willemsen, G. (Gonneke), Agudo, A. (Antonio), Boeing, H. (Heiner), Boomsma, D.I. (Dorret), Chirlaque, M.D. (M.), Fagherazzi, G. (Guy), Ferrari, P. (Pietro), Franks, P. (Paul), Gieger, C. (Christian), Hagen, K. (Knut), Gunter, M.J. (Marc J.), Hägg, S. (Sara), Hovatta, I. (Iiris), Imaz, L. (Liher), Kaprio, J. (Jaakko), Kaaks, R. (Rudolf), Key, T. (Tim), Krogh, V. (Vittorio), Martin, N.G. (Nicholas), Melander, O. (Olle), Metspalu, A. (Andres), Moreno, C. (Concha), Onland-Moret, N.C. (N. Charlotte), Nilsson, P. (Peter), Ong, K.K. (Ken K.), Overvad, K. (Kim), Palli, D. (Domenico), Panico, S. (Salvatore), Pedersen, N.L. (Nancy), Penninx, B.W.J.H. (Brenda), Quirós, J.R., Jarvelin, M.R. (Marjo Riitta), Rodríguez-Barranco, M. (Miguel), Scott, R.A. (Robert A.), Severi, G. (Gianluca), Slagboom, P.E. (Eline), Spector, T.D. (Timothy), Tjønneland, A. (Anne), Trichopoulou, A. (Antonia), Tumino, R. (Rosario), Uitterlinden, A.G. (André G.), Schouw, Y.T. (Yvonne) van der, Duijn, C.M. (Cornelia) van, Weiderpass, E. (Elisabete), Denchi, E.L. (Eros Lazzerini), Matullo, G., Butterworth, A.S. (Adam S.), Danesh, J. (John), Samani, N.J. (Nilesh), Wareham, N.J. (Nick), Nelson, C.P. (Christopher P.), Langenberg, C. (Claudia), and Codd, V. (Veryan)
Abstract: Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1, PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
Published: 2020
Full Text: View/download PDF

14. A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

Author: Escala-Garcia, M. (Maria), Abraham, J. (Jean), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Ashworth, A. (Alan), Auer, P. L. (Paul L.), Auvinen, P. (Paivi), Beckmann, M. W. (Matthias W.), Beesley, J. (Jonathan), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Blomqvist, C. (Carl), Blot, W. (William), Bogdanova, N. V. (Natalia V.), Bojesen, S. E. (Stig E.), Bolla, M. K. (Manjeet K.), Borresen-Dale, A.-L. (Anne-Lise), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brucker, S. Y. (Sara Y.), Burwinkel, B. (Barbara), Caldas, C. (Carlos), Canzian, F. (Federico), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chin, S.-F. (Suet-Feung), Clarke, C. L. (Christine L.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Dennis, J. (Joe), Devilee, P. (Peter), Dunn, J. A. (Janet A.), Dunning, A. M. (Alison M.), Dwek, M. (Miriam), Earl, H. M. (Helena M.), Eccles, D. M. (Diana M.), Eliassen, A. H. (A. Heather), Ellberg, C. (Carolina), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), George, A. (Angela), Giles, G. G. (Graham G.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Grip, M. (Mervi), Guenel, P. (Pascal), Guo, Q. (Qi), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hamann, U. (Ute), Harrington, P. A. (Patricia A.), Hiller, L. (Louise), Hooning, M. J. (Maartje J.), Hopper, J. L. (John L.), Howell, A. (Anthony), Huang, C.-S. (Chiun-Sheng), Huang, G. (Guanmengqian), Hunter, D. J. (David J.), Jakubowska, A. (Anna), John, E. M. (Esther M.), Kaaks, R. (Rudolf), Kapoor, P. M. (Pooja Middha), Keeman, R. (Renske), Kitahara, C. M. (Cari M.), Koppert, L. B. (Linetta B.), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lejbkowicz, F. (Flavio), Lindblom, A. (Annika), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martinez, M. E. (Maria Elena), Maurer, T. (Tabea), Mavroudis, D. (Dimitrios), Meindl, A. (Alfons), Milne, R. L. (Roger L.), Mulligan, A. M. (Anna Marie), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Olshan, A. F. (Andrew F.), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Orr, N. (Nick), Peterlongo, P. (Paolo), Petridis, C. (Christos), Prentice, R. L. (Ross L.), Presneau, N. (Nadege), Punie, K. (Kevin), Ramachandran, D. (Dhanya), Rennert, G. (Gad), Romero, A. (Atocha), Sachchithananthan, M. (Mythily), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Schwentner, L. (Lukas), Scott, C. (Christopher), Simard, J. (Jacques), Sohn, C. (Christof), Southey, M. C. (Melissa C.), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Teixeira, M. R. (Manuel R.), Terry, M. B. (Mary Beth), Thorne, H. (Heather), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Turnbull, C. (Clare), Vachon, C. M. (Celine M.), van der Kolk, L. E. (Lizet E.), Wang, Q. (Qin), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Ziogas, A. (Argyrios), Pharoah, P. D. (Paul D. P.), Hall, P. (Per), Wessels, L. F. (Lodewyk F. A.), Chenevix-Trench, G. (Georgia), Bader, G. D. (Gary D.), Doerk, T. (Thilo), Easton, D. F. (Douglas F.), Canisius, S. (Sander), Schmidt, M. K. (Marjanka K.), Escala-Garcia, M. (Maria), Abraham, J. (Jean), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Ashworth, A. (Alan), Auer, P. L. (Paul L.), Auvinen, P. (Paivi), Beckmann, M. W. (Matthias W.), Beesley, J. (Jonathan), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Blomqvist, C. (Carl), Blot, W. (William), Bogdanova, N. V. (Natalia V.), Bojesen, S. E. (Stig E.), Bolla, M. K. (Manjeet K.), Borresen-Dale, A.-L. (Anne-Lise), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brucker, S. Y. (Sara Y.), Burwinkel, B. (Barbara), Caldas, C. (Carlos), Canzian, F. (Federico), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chin, S.-F. (Suet-Feung), Clarke, C. L. (Christine L.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Dennis, J. (Joe), Devilee, P. (Peter), Dunn, J. A. (Janet A.), Dunning, A. M. (Alison M.), Dwek, M. (Miriam), Earl, H. M. (Helena M.), Eccles, D. M. (Diana M.), Eliassen, A. H. (A. Heather), Ellberg, C. (Carolina), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), George, A. (Angela), Giles, G. G. (Graham G.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Grip, M. (Mervi), Guenel, P. (Pascal), Guo, Q. (Qi), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hamann, U. (Ute), Harrington, P. A. (Patricia A.), Hiller, L. (Louise), Hooning, M. J. (Maartje J.), Hopper, J. L. (John L.), Howell, A. (Anthony), Huang, C.-S. (Chiun-Sheng), Huang, G. (Guanmengqian), Hunter, D. J. (David J.), Jakubowska, A. (Anna), John, E. M. (Esther M.), Kaaks, R. (Rudolf), Kapoor, P. M. (Pooja Middha), Keeman, R. (Renske), Kitahara, C. M. (Cari M.), Koppert, L. B. (Linetta B.), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lejbkowicz, F. (Flavio), Lindblom, A. (Annika), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martinez, M. E. (Maria Elena), Maurer, T. (Tabea), Mavroudis, D. (Dimitrios), Meindl, A. (Alfons), Milne, R. L. (Roger L.), Mulligan, A. M. (Anna Marie), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Olshan, A. F. (Andrew F.), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Orr, N. (Nick), Peterlongo, P. (Paolo), Petridis, C. (Christos), Prentice, R. L. (Ross L.), Presneau, N. (Nadege), Punie, K. (Kevin), Ramachandran, D. (Dhanya), Rennert, G. (Gad), Romero, A. (Atocha), Sachchithananthan, M. (Mythily), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Schwentner, L. (Lukas), Scott, C. (Christopher), Simard, J. (Jacques), Sohn, C. (Christof), Southey, M. C. (Melissa C.), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Teixeira, M. R. (Manuel R.), Terry, M. B. (Mary Beth), Thorne, H. (Heather), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Turnbull, C. (Clare), Vachon, C. M. (Celine M.), van der Kolk, L. E. (Lizet E.), Wang, Q. (Qin), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Ziogas, A. (Argyrios), Pharoah, P. D. (Paul D. P.), Hall, P. (Per), Wessels, L. F. (Lodewyk F. A.), Chenevix-Trench, G. (Georgia), Bader, G. D. (Gary D.), Doerk, T. (Thilo), Easton, D. F. (Douglas F.), Canisius, S. (Sander), and Schmidt, M. K. (Marjanka K.)
Abstract: Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
Published: 2020

15. Genome-wide association study of germline variants and breast cancer-specific mortality

Author: Escala-Garcia, M. (Maria), Guo, Q. (Qi), Doerk, T. (Thilo), Canisius, S. (Sander), Keeman, R. (Renske), Dennis, J. (Joe), Beesley, J. (Jonathan), Lecarpentier, J. (Julie), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Abraham, J. (Jean), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Auer, P. L. (Paul L.), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Blomqvist, C. (Carl), Boeckx, B. (Bram), Bojesen, S. E. (Stig E.), Bonanni, B. (Bernardo), Borresen-Dale, A.-L. (Anne-Lise), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brentnall, A. (Adam), Brinton, L. (Louise), Broberg, P. (Per), Brock, I. W. (Ian W.), Brucker, S. Y. (Sara Y.), Burwinkel, B. (Barbara), Caldas, C. (Carlos), Caldes, T. (Trinidad), Campa, D. (Daniele), Canzian, F. (Federico), Carracedo, A. (Angel), Carter, B. D. (Brian D.), Castelao, J. E. (Jose E.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Cheng, T. D. (Ting-Yuan David), Chin, S.-F. (Suet-Feung), Clarke, C. L. (Christine L.), Cordina-Duverger, E. (Emilie), Couch, F. J. (Fergus J.), Cox, D. G. (David G.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Dunn, J. A. (Janet A.), Dunning, A. M. (Alison M.), Durcan, L. (Lorraine), Dwek, M. (Miriam), Earl, H. M. (Helena M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Ellberg, C. (Carolina), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Figueroa, J. (Jonine), Flesch-Janys, D. (Dieter), Flyger, H. (Henrik), Gabrielson, M. (Marike), Gago-Dominguez, M. (Manuela), Galle, E. (Eva), Gapstur, S. M. (Susan M.), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), George, A. (Angela), Georgoulias, V. (Vassilios), Giles, G. G. (Graham G.), Glendon, G. (Gord), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Alnaes, G. I. (Grethe I. Grenaker), Grip, M. (Mervi), Guenel, P. (Pascal), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hankinson, S. (Susan), Harkness, E. F. (Elaine F.), Harrington, P. A. (Patricia A.), Hart, S. N. (Steven N.), Hartikainen, J. M. (Jaana M.), Hein, A. (Alexander), Hillemanns, P. (Peter), Hiller, L. (Louise), Holleczek, B. (Bernd), Hollestelle, A. (Antoinette), Hooning, M. J. (Maartje J.), Hoover, R. N. (Robert N.), Hopper, J. L. (John L.), Howell, A. (Anthony), Huang, G. (Guanmengqian), Humphreys, K. (Keith), Hunter, D. J. (David J.), Janni, W. (Wolfgang), John, E. M. (Esther M.), Jones, M. E. (Michael E.), Jukkola-Vuorinen, A. (Arja), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kabisch, M. (Maria), Kaczmarek, K. (Katarzyna), Kerin, M. J. (Michael J.), Khan, S. (Sofia), Khusnutdinova, E. (Elza), Kiiski, J. I. (Johanna, I), Kitahara, C. M. (Cari M.), Knight, J. A. (Julia A.), Ko, Y.-D. (Yon-Dschun), Koppert, L. B. (Linetta B.), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kruger, U. (Ute), Kuehl, T. (Tabea), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lee, E. (Eunjung), Lejbkowicz, F. (Flavio), Li, L. (Lian), Lindblom, A. (Annika), Lindstrom, S. (Sara), Linet, M. (Martha), Lissowska, J. (Jolanta), Lo, W.-Y. (Wing-Yee), Loibl, S. (Sibylle), Lubinski, J. (Jan), Lux, M. P. (Michael P.), MacInnis, R. J. (Robert J.), Maierthaler, M. (Melanie), Maishman, T. (Tom), Makalic, E. (Enes), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martinez, M. E. (Maria Elena), Mavroudis, D. (Dimitrios), McLean, C. (Catriona), Meindl, A. (Alfons), Middha, P. (Pooja), Miller, N. (Nicola), Milne, R. L. (Roger L.), Moreno, F. (Fernando), Mulligan, A. M. (Anna Marie), Mulot, C. (Claire), Nassir, R. (Rami), Neuhausen, S. L. (Susan L.), Newman, W. T. (William T.), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Norman, A. (Aaron), Olsson, H. (Hakan), Orr, N. (Nick), Pankratz, V. S. (V. Shane), Park-Simon, T.-W. (Tjoung-Won), Perez, J. I. (Jose I. A.), Perez-Barrios, C. (Clara), Peterlongo, P. (Paolo), Petridis, C. (Christos), Pinchev, M. (Mila), Prajzendanc, K. (Karoliona), Prentice, R. (Ross), Presneau, N. (Nadege), Prokofieva, D. (Darya), Pylkas, K. (Katri), Rack, B. (Brigitte), Radice, P. (Paolo), Ramachandran, D. (Dhanya), Rennert, G. (Gadi), Rennert, H. S. (Hedy S.), Rhenius, V. (Valerie), Romero, A. (Atocha), Roylance, R. (Rebecca), Saloustros, E. (Emmanouil), Sawyer, E. J. (Elinor J.), Schmidt, D. F. (Daniel F.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Schoemaker, M. J. (Minouk J.), Schumacher, F. (Fredrick), Schwentner, L. (Lukas), Scott, R. J. (Rodney J.), Scott, C. (Christopher), Seynaeve, C. (Caroline), Shah, M. (Mitul), Simard, J. (Jacques), Smeets, A. (Ann), Sohn, C. (Christof), Southey, M. C. (Melissa C.), Swerdlow, A. J. (Anthony J.), Talhouk, A. (Aline), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Teixeira, M. R. (Manuel R.), Tengstrom, M. (Maria), Terry, M. B. (Mary Beth), Thoene, K. (Kathrin), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Torres, D. (Diana), Truong, T. (Therese), Turman, C. (Constance), Turnbull, C. (Clare), Ulmer, H.-U. (Hans-Ulrich), Untch, M. (Michael), Vachon, C. (Celine), van Asperen, C. J. (Christi J.), van den Ouweland, A. M. (Ans M. W.), van Veen, E. M. (Elke M.), Wendt, C. (Camilla), Whittemore, A. S. (Alice S.), Willett, W. (Walter), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Zhang, Y. (Yan), Easton, D. F. (Douglas F.), Fasching, P. A. (Peter A.), Nevanlinna, H. (Heli), Eccles, D. M. (Diana M.), Pharoah, P. D. (Paul D. P.), and Schmidt, M. K. (Marjanka K.)
Abstract: Background: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. Methods: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). Results: We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10−8. For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 × 10−7, hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.84–0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP = 11%, P = 1.38 × 10−7, HR = 1.27, 95% CI = 1.16–1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. Conclusions: We uncovered germline variants on chromosome 7 at BFDP
Published: 2019

16. Polygenic risk scores for prediction of breast cancer and breast cancer subtypes

Author: Mavaddat, N. (Nasim), Michailidou, K. (Kyriaki), Dennis, J. (Joe), Lush, M. (Michael), Fachal, L. (Laura), Lee, A. (Andrew), Tyrer, J. P. (Jonathan P.), Chen, T.-H. (Ting-Huei), Wang, Q. (Qin), Bolla, M. K. (Manjeet K.), Yang, X. (Xin), Adank, M. A. (Muriel A.), Ahearn, T. (Thomas), Aittomaki, K. (Kristiina), Allen, J. (Jamie), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Auer, P. L. (Paul L.), Auvinen, P. (Paivi), Barrdahl, M. (Myrto), Freeman, L. E. (Laura E. Beane), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Blomqvist, C. (Carl), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Bonanni, B. (Bernardo), Borresen-Dale, A.-L. (Anne-Lise), Brauch, H. (Hiltrud), Bremer, M. (Michael), Brenner, H. (Hermann), Brentnall, A. (Adam), Brock, I. W. (Ian W.), Brooks-Wilson, A. (Angela), Brucker, S. Y. (Sara Y.), Bruening, T. (Thomas), Burwinkel, B. (Barbara), Campa, D. (Daniele), Carter, B. D. (Brian D.), Castelao, J. E. (Jose E.), Chanock, S. J. (Stephen J.), Chlebowski, R. (Rowan), Christiansen, H. (Hans), Clarke, C. L. (Christine L.), Collee, J. M. (J. Margriet), Cordina-Duverger, E. (Emilie), Cornelissen, S. (Sten), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Doerk, T. (Thilo), dos-Santos-Silva, I. (Isabel), Dumont, M. (Martine), Durcan, L. (Lorraine), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Ellberg, C. (Carolina), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Fletcher, O. (Olivia), Flyger, H. (Henrik), Foersti, A. (Asta), Fritschi, L. (Lin), Gabrielson, M. (Marike), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), Georgoulias, V. (Vassilios), Giles, G. G. (Graham G.), Gilyazova, I. R. (Irina R.), Glendon, G. (Gord), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Alnaes, G. I. (Grethe I. Grenaker), Grip, M. (Mervi), Gronwald, J. (Jacek), Grundy, A. (Anne), Guenel, P. (Pascal), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hamann, U. (Ute), Hankinson, S. E. (Susan E.), Harkness, E. F. (Elaine F.), Hart, S. N. (Steven N.), He, W. (Wei), Hein, A. (Alexander), Heyworth, J. (Jane), Hillemanns, P. (Peter), Hollestelle, A. (Antoinette), Hooning, M. J. (Maartje J.), Hoover, R. N. (Robert N.), Hopper, J. L. (John L.), Howell, A. (Anthony), Huang, G. (Guanmengqian), Humphreys, K. (Keith), Hunter, D. J. (David J.), Jakimovska, M. (Milena), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Johnson, N. (Nichola), Jones, M. E. (Michael E.), Jukkola-Vuorinen, A. (Arja), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kaczmarek, K. (Katarzyna), Kataja, V. (Vesa), Keeman, R. (Renske), Kerin, M. J. (Michael J.), Khusnutdinova, E. (Elza), Kiiski, J. I. (Johanna, I), Knight, J. A. (Julia A.), Ko, Y.-D. (Yon-Dschun), Kosma, V.-M. (Veli-Matti), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Kruger, U. (Ute), Kuehl, T. (Tabea), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lee, E. (Eunjung), Lejbkowicz, F. (Flavio), Lilyquist, J. (Jenna), Lindblom, A. (Annika), Lindstrom, S. (Sara), Lissowska, J. (Jolanta), Lo, W.-Y. (Wing-Yee), Loibl, S. (Sibylle), Long, J. (Jirong), Lubinski, J. (Jan), Lux, M. P. (Michael P.), MacInnis, R. J. (Robert J.), Maishman, T. (Tom), Makalic, E. (Enes), Kostovska, I. M. (Ivana Maleva), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martens, J. W. (John W. M.), Martinez, M. E. (Maria Elena), Mavroudis, D. (Dimitrios), McLean, C. (Catriona), Meindl, A. (Alfons), Menon, U. (Usha), Middha, P. (Pooja), Miller, N. (Nicola), Moreno, F. (Fernando), Mulligan, A. M. (Anna Marie), Mulot, C. (Claire), Munoz-Garzon, V. M. (Victor M.), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Neven, P. (Patrick), Newman, W. G. (William G.), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Norman, A. (Aaron), Offit, K. (Kenneth), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Orr, N. (Nick), Pankratz, V. S. (V. Shane), Park-Simon, T.-W. (Tjoung-Won), Perez, J. I. (Jose I. A.), Perez-Barrios, C. (Clara), Peterlongo, P. (Paolo), Peto, J. (Julian), Pinchev, M. (Mila), Plaseska-Karanfilska, D. (Dijana), Polley, E. C. (Eric C.), Prentice, R. (Ross), Presneau, N. (Nadege), Prokofyeva, D. (Darya), Purrington, K. (Kristen), Pylkäs, K. (Katri), Rack, B. (Brigitte), Radice, P. (Paolo), Rau-Murthy, R. (Rohini), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Rhenius, V. (Valerie), Robson, M. (Mark), Romero, A. (Atocha), Ruddy, K. J. (Kathryn J.), Ruebner, M. (Matthias), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, D. F. (Daniel F.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Schoemaker, M. J. (Minouk J.), Schumacher, F. (Fredrick), Schuermann, P. (Peter), Schwentner, L. (Lukas), Scott, C. (Christopher), Scott, R. J. (Rodney J.), Seynaeve, C. (Caroline), Shah, M. (Mitul), Sherman, M. E. (Mark E.), Shrubsole, M. J. (Martha J.), Shu, X.-O. (Xiao-Ou), Slager, S. (Susan), Smeets, A. (Ann), Sohn, C. (Christof), Soucy, P. (Penny), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stegmaier, C. (Christa), Stone, J. (Jennifer), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Terry, M. B. (Mary Beth), Thoene, K. (Kathrin), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Truong, T. (Therese), Tzardi, M. (Maria), Ulmer, H.-U. (Hans-Ulrich), Untch, M. (Michael), Vachon, C. M. (Celine M.), van Veen, E. M. (Elke M.), Vijai, J. (Joseph), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Whittemore, A. S. (Alice S.), Wildiers, H. (Hans), Willett, W. (Walter), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Zhang, Y. (Yan), Zheng, W. (Wei), Ziogas, A. (Argyrios), Clarke, C. (Christine), Balleine, R. (Rosemary), Baxter, R. (Robert), Braye, S. (Stephen), Carpenter, J. (Jane), Dahlstrom, J. (Jane), Forbes, J. (John), Lee, C. S. (C. Soon), Marsh, D. (Deborah), Morey, A. (Adrienne), Pathmanathan, N. (Nirmala), Scott, R. (Rodney), Simpson, P. (Peter), Spigelman, A. (Allan), Wilcken, N. (Nicholas), Yip, D. (Desmond), Zeps, N. (Nikolajs), Sexton, A. (Adrienne), Dobrovic, A. (Alex), Christian, A. (Alice), Trainer, A. (Alison), Fellows, A. (Andrew), Shelling, A. (Andrew), De Fazio, A. (Anna), Blackburn, A. (Anneke), Crook, A. (Ashley), Meiser, B. (Bettina), Patterson, B. (Briony), Clarke, C. (Christobel), Saunders, C. (Christobel), Hunt, C. (Clare), Scott, C. (Clare), Amor, D. (David), Ortega, D. G. (David Gallego), Marsh, D. (Deb), Edkins, E. (Edward), Salisbury, E. (Elizabeth), Haan, E. (Eric), Macrea, F. (Finlay), Farshid, G. (Gelareh), Lindeman, G. (Geoff), Trench, G. (Georgia), Mann, G. (Graham), Giles, G. (Graham), Gill, G. (Grantley), Thorne, H. (Heather), Campbell, I. (Ian), Hickie, I. (Ian), Caldon, L. (Liz), Winship, I. (Ingrid), Cui, J. (James), Flanagan, J. (James), Kollias, J. (James), Visvader, J. (Jane), Taylor, J. (Jessica), Burke, J. (Jo), Saunus, J. (Jodi), Forbs, J. (John), Hopper, J. (John), Beesley, J. (Jonathan), Kirk, J. (Judy), French, J. (Juliet), Tucker, K. (Kathy), Wu, K. (Kathy), Phillips, K. (Kelly), Forrest, L. (Laura), Lipton, L. (Lara), Andrews, L. (Leslie), Lobb, L. (Lizz), Walker, L. (Logan), Kentwell, M. (Maira), Spurdle, M. (Mandy), Cummings, M. (Margaret), Gleeson, M. (Margaret), Harris, M. (Marion), Jenkins, M. (Mark), Young, M. A. (Mary Anne), Delatycki, M. (Martin), Wallis, M. (Mathew), Burgess, M. (Matthew), Brown, M. (Melissa), Southey, M. (Melissa), Bogwitz, M. (Michael), Field, M. (Michael), Friedlander, M. (Michael), Gattas, M. (Michael), Saleh, M. (Mona), Aghmesheh, M. (Morteza), Hayward, N. (Nick), Pachter, N. (Nick), Cohen, P. (Paul), Duijf, P. (Pascal), James, P. (Paul), Simpson, P. (Pete), Fong, P. (Peter), Butow, P. (Phyllis), Williams, R. (Rachael), Kefford, R. (Rick), Simard, J. (Jacques), Balleine, R.-M. (Rose-Mary), Dawson, S.-J. (Sarah-Jane), Lok, S. (Sheau), O'connell, S. (Shona), Greening, S. (Sian), Nightingale, S. (Sophie), Edwards, S. (Stacey), Fox, S. (Stephen), McLachlan, S.-A. (Sue-Anne), Lakhani, S. (Sunil), Dudding, T. (Tracy), Antill, Y. (Yoland), Sahlberg, K. K. (Kristine K.), Ottestad, L. (Lars), Karesen, R. (Rolf), Schlichting, E. (Ellen), Holmen, M. M. (Marit Muri), Sauer, T. (Toril), Haakensen, V. (Vilde), Engebraten, O. (Olav), Naume, B. (Bjorn), Fossa, A. (Alexander), Kiserud, C. E. (Cecile E.), Reinertsen, K. V. (Kristin, V), Helland, A. (Aslaug), Riis, M. (Margit), Geisler, J. (Juergen), Dunning, A. M. (Alison M.), Thompson, D. J. (Deborah J.), Chenevix-Trench, G. (Georgia), Chang-Claude, J. (Jenny), Schmidt, M. K. (Marjanka K.), Hall, P. (Per), Milne, R. L. (Roger L.), Pharoah, P. D. (Paul D. P.), Antoniou, A. C. (Antonis C.), Chatterjee, N. (Nilanjan), Kraft, P. (Peter), Garcia-Closas, M. (Montserrat), Easton, D. F. (Douglas F.), Mavaddat, N. (Nasim), Michailidou, K. (Kyriaki), Dennis, J. (Joe), Lush, M. (Michael), Fachal, L. (Laura), Lee, A. (Andrew), Tyrer, J. P. (Jonathan P.), Chen, T.-H. (Ting-Huei), Wang, Q. (Qin), Bolla, M. K. (Manjeet K.), Yang, X. (Xin), Adank, M. A. (Muriel A.), Ahearn, T. (Thomas), Aittomaki, K. (Kristiina), Allen, J. (Jamie), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Auer, P. L. (Paul L.), Auvinen, P. (Paivi), Barrdahl, M. (Myrto), Freeman, L. E. (Laura E. Beane), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Blomqvist, C. (Carl), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Bonanni, B. (Bernardo), Borresen-Dale, A.-L. (Anne-Lise), Brauch, H. (Hiltrud), Bremer, M. (Michael), Brenner, H. (Hermann), Brentnall, A. (Adam), Brock, I. W. (Ian W.), Brooks-Wilson, A. (Angela), Brucker, S. Y. (Sara Y.), Bruening, T. (Thomas), Burwinkel, B. (Barbara), Campa, D. (Daniele), Carter, B. D. (Brian D.), Castelao, J. E. (Jose E.), Chanock, S. J. (Stephen J.), Chlebowski, R. (Rowan), Christiansen, H. (Hans), Clarke, C. L. (Christine L.), Collee, J. M. (J. Margriet), Cordina-Duverger, E. (Emilie), Cornelissen, S. (Sten), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Doerk, T. (Thilo), dos-Santos-Silva, I. (Isabel), Dumont, M. (Martine), Durcan, L. (Lorraine), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Ellberg, C. (Carolina), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Fletcher, O. (Olivia), Flyger, H. (Henrik), Foersti, A. (Asta), Fritschi, L. (Lin), Gabrielson, M. (Marike), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Saenz, J. A. (Jose A.), Gaudet, M. M. (Mia M.), Georgoulias, V. (Vassilios), Giles, G. G. (Graham G.), Gilyazova, I. R. (Irina R.), Glendon, G. (Gord), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Alnaes, G. I. (Grethe I. Grenaker), Grip, M. (Mervi), Gronwald, J. (Jacek), Grundy, A. (Anne), Guenel, P. (Pascal), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hamann, U. (Ute), Hankinson, S. E. (Susan E.), Harkness, E. F. (Elaine F.), Hart, S. N. (Steven N.), He, W. (Wei), Hein, A. (Alexander), Heyworth, J. (Jane), Hillemanns, P. (Peter), Hollestelle, A. (Antoinette), Hooning, M. J. (Maartje J.), Hoover, R. N. (Robert N.), Hopper, J. L. (John L.), Howell, A. (Anthony), Huang, G. (Guanmengqian), Humphreys, K. (Keith), Hunter, D. J. (David J.), Jakimovska, M. (Milena), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Johnson, N. (Nichola), Jones, M. E. (Michael E.), Jukkola-Vuorinen, A. (Arja), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kaczmarek, K. (Katarzyna), Kataja, V. (Vesa), Keeman, R. (Renske), Kerin, M. J. (Michael J.), Khusnutdinova, E. (Elza), Kiiski, J. I. (Johanna, I), Knight, J. A. (Julia A.), Ko, Y.-D. (Yon-Dschun), Kosma, V.-M. (Veli-Matti), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Kruger, U. (Ute), Kuehl, T. (Tabea), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lee, E. (Eunjung), Lejbkowicz, F. (Flavio), Lilyquist, J. (Jenna), Lindblom, A. (Annika), Lindstrom, S. (Sara), Lissowska, J. (Jolanta), Lo, W.-Y. (Wing-Yee), Loibl, S. (Sibylle), Long, J. (Jirong), Lubinski, J. (Jan), Lux, M. P. (Michael P.), MacInnis, R. J. (Robert J.), Maishman, T. (Tom), Makalic, E. (Enes), Kostovska, I. M. (Ivana Maleva), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martens, J. W. (John W. M.), Martinez, M. E. (Maria Elena), Mavroudis, D. (Dimitrios), McLean, C. (Catriona), Meindl, A. (Alfons), Menon, U. (Usha), Middha, P. (Pooja), Miller, N. (Nicola), Moreno, F. (Fernando), Mulligan, A. M. (Anna Marie), Mulot, C. (Claire), Munoz-Garzon, V. M. (Victor M.), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Neven, P. (Patrick), Newman, W. G. (William G.), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Norman, A. (Aaron), Offit, K. (Kenneth), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Orr, N. (Nick), Pankratz, V. S. (V. Shane), Park-Simon, T.-W. (Tjoung-Won), Perez, J. I. (Jose I. A.), Perez-Barrios, C. (Clara), Peterlongo, P. (Paolo), Peto, J. (Julian), Pinchev, M. (Mila), Plaseska-Karanfilska, D. (Dijana), Polley, E. C. (Eric C.), Prentice, R. (Ross), Presneau, N. (Nadege), Prokofyeva, D. (Darya), Purrington, K. (Kristen), Pylkäs, K. (Katri), Rack, B. (Brigitte), Radice, P. (Paolo), Rau-Murthy, R. (Rohini), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Rhenius, V. (Valerie), Robson, M. (Mark), Romero, A. (Atocha), Ruddy, K. J. (Kathryn J.), Ruebner, M. (Matthias), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, D. F. (Daniel F.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Schoemaker, M. J. (Minouk J.), Schumacher, F. (Fredrick), Schuermann, P. (Peter), Schwentner, L. (Lukas), Scott, C. (Christopher), Scott, R. J. (Rodney J.), Seynaeve, C. (Caroline), Shah, M. (Mitul), Sherman, M. E. (Mark E.), Shrubsole, M. J. (Martha J.), Shu, X.-O. (Xiao-Ou), Slager, S. (Susan), Smeets, A. (Ann), Sohn, C. (Christof), Soucy, P. (Penny), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stegmaier, C. (Christa), Stone, J. (Jennifer), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Terry, M. B. (Mary Beth), Thoene, K. (Kathrin), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Truong, T. (Therese), Tzardi, M. (Maria), Ulmer, H.-U. (Hans-Ulrich), Untch, M. (Michael), Vachon, C. M. (Celine M.), van Veen, E. M. (Elke M.), Vijai, J. (Joseph), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Whittemore, A. S. (Alice S.), Wildiers, H. (Hans), Willett, W. (Walter), Winqvist, R. (Robert), Wolk, A. (Alicja), Yang, X. R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Zhang, Y. (Yan), Zheng, W. (Wei), Ziogas, A. (Argyrios), Clarke, C. (Christine), Balleine, R. (Rosemary), Baxter, R. (Robert), Braye, S. (Stephen), Carpenter, J. (Jane), Dahlstrom, J. (Jane), Forbes, J. (John), Lee, C. S. (C. Soon), Marsh, D. (Deborah), Morey, A. (Adrienne), Pathmanathan, N. (Nirmala), Scott, R. (Rodney), Simpson, P. (Peter), Spigelman, A. (Allan), Wilcken, N. (Nicholas), Yip, D. (Desmond), Zeps, N. (Nikolajs), Sexton, A. (Adrienne), Dobrovic, A. (Alex), Christian, A. (Alice), Trainer, A. (Alison), Fellows, A. (Andrew), Shelling, A. (Andrew), De Fazio, A. (Anna), Blackburn, A. (Anneke), Crook, A. (Ashley), Meiser, B. (Bettina), Patterson, B. (Briony), Clarke, C. (Christobel), Saunders, C. (Christobel), Hunt, C. (Clare), Scott, C. (Clare), Amor, D. (David), Ortega, D. G. (David Gallego), Marsh, D. (Deb), Edkins, E. (Edward), Salisbury, E. (Elizabeth), Haan, E. (Eric), Macrea, F. (Finlay), Farshid, G. (Gelareh), Lindeman, G. (Geoff), Trench, G. (Georgia), Mann, G. (Graham), Giles, G. (Graham), Gill, G. (Grantley), Thorne, H. (Heather), Campbell, I. (Ian), Hickie, I. (Ian), Caldon, L. (Liz), Winship, I. (Ingrid), Cui, J. (James), Flanagan, J. (James), Kollias, J. (James), Visvader, J. (Jane), Taylor, J. (Jessica), Burke, J. (Jo), Saunus, J. (Jodi), Forbs, J. (John), Hopper, J. (John), Beesley, J. (Jonathan), Kirk, J. (Judy), French, J. (Juliet), Tucker, K. (Kathy), Wu, K. (Kathy), Phillips, K. (Kelly), Forrest, L. (Laura), Lipton, L. (Lara), Andrews, L. (Leslie), Lobb, L. (Lizz), Walker, L. (Logan), Kentwell, M. (Maira), Spurdle, M. (Mandy), Cummings, M. (Margaret), Gleeson, M. (Margaret), Harris, M. (Marion), Jenkins, M. (Mark), Young, M. A. (Mary Anne), Delatycki, M. (Martin), Wallis, M. (Mathew), Burgess, M. (Matthew), Brown, M. (Melissa), Southey, M. (Melissa), Bogwitz, M. (Michael), Field, M. (Michael), Friedlander, M. (Michael), Gattas, M. (Michael), Saleh, M. (Mona), Aghmesheh, M. (Morteza), Hayward, N. (Nick), Pachter, N. (Nick), Cohen, P. (Paul), Duijf, P. (Pascal), James, P. (Paul), Simpson, P. (Pete), Fong, P. (Peter), Butow, P. (Phyllis), Williams, R. (Rachael), Kefford, R. (Rick), Simard, J. (Jacques), Balleine, R.-M. (Rose-Mary), Dawson, S.-J. (Sarah-Jane), Lok, S. (Sheau), O'connell, S. (Shona), Greening, S. (Sian), Nightingale, S. (Sophie), Edwards, S. (Stacey), Fox, S. (Stephen), McLachlan, S.-A. (Sue-Anne), Lakhani, S. (Sunil), Dudding, T. (Tracy), Antill, Y. (Yoland), Sahlberg, K. K. (Kristine K.), Ottestad, L. (Lars), Karesen, R. (Rolf), Schlichting, E. (Ellen), Holmen, M. M. (Marit Muri), Sauer, T. (Toril), Haakensen, V. (Vilde), Engebraten, O. (Olav), Naume, B. (Bjorn), Fossa, A. (Alexander), Kiserud, C. E. (Cecile E.), Reinertsen, K. V. (Kristin, V), Helland, A. (Aslaug), Riis, M. (Margit), Geisler, J. (Juergen), Dunning, A. M. (Alison M.), Thompson, D. J. (Deborah J.), Chenevix-Trench, G. (Georgia), Chang-Claude, J. (Jenny), Schmidt, M. K. (Marjanka K.), Hall, P. (Per), Milne, R. L. (Roger L.), Pharoah, P. D. (Paul D. P.), Antoniou, A. C. (Antonis C.), Chatterjee, N. (Nilanjan), Kraft, P. (Peter), Garcia-Closas, M. (Montserrat), and Easton, D. F. (Douglas F.)
Abstract: Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57–1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628–0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.
Published: 2019

17. Risk thresholds for alcohol consumption:combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Author: Wood, A. M. (Angela M.), Kaptoge, S. (Stephen), Butterworth, A. S. (Adam S.), Willeit, P. (Peter), Warnakula, S. (Samantha), Bolton, T. (Thomas), Paige, E. (Ellie), Paul, D. S. (Dirk S.), Sweeting, M. (Michael), Burgess, S. (Stephen), Bell, S. (Steven), Astle, W. (William), Stevens, D. (David), Koulman, A. (Albert), Selmer, R. M. (Randi M.), Verschuren, W. M. (W. M. Monique), Sato, S. (Shinichi), Njolstad, I. (Inger), Woodward, M. (Mark), Salomaa, V. (Veikko), Nordestgaard, B. G. (Borge G.), Yeap, B. B. (Bu B.), Fletcher, A. (Astrid), Melander, O. (Olle), Kuller, L. H. (Lewis H.), Balkau, B. (Beverley), Marmot, M. (Michael), Koenig, W. (Wolfgang), Casiglia, E. (Edoardo), Cooper, C. (Cyrus), Arndt, V. (Volker), Franco, O. H. (Oscar H.), Wennberg, P. (Patrik), Gallacher, J. (John), de la Camara, A. G. (Agustin Gomez), Volzke, H. (Henry), Dahm, C. C. (Christina C.), Dale, C. E. (Caroline E.), Bergmann, M. M. (Manuela M.), Crespo, C. J. (Carlos J.), van der Schouw, Y. T. (Yvonne T.), Kaaks, R. (Rudolf), Simons, L. A. (Leon A.), Lagiou, P. (Pagona), Schoufour, J. D. (Josje D.), Boer, J. M. (Jolanda M. A.), Key, T. J. (Timothy J.), Rodriguez, B. (Beatriz), Moreno-Iribas, C. (Conchi), Davidson, K. W. (Karina W.), Taylor, J. O. (James O.), Sacerdote, C. (Carlotta), Wallace, R. B. (Robert B.), Quiros, J. R. (J. Ramon), Tumino, R. (Rosario), Blazer, D. G. (Dan G., II), Linneberg, A. (Allan), Daimon, M. (Makoto), Panico, S. (Salvatore), Howard, B. (Barbara), Skeie, G. (Guri), Strandberg, T. (Timo), Weiderpass, E. (Elisabete), Nietert, P. J. (Paul J.), Psaty, B. M. (Bruce M.), Kromhout, D. (Daan), Salamanca-Fernandez, E. (Elena), Kiechl, S. (Stefan), Krumholz, H. M. (Harlan M.), Grioni, S. (Sara), Palli, D. (Domenico), Huerta, J. M. (Jose M.), Price, J. (Jackie), Sundstrom, J. (Johan), Arriola, L. (Larraitz), Arima, H. (Hisatomi), Travis, R. C. (Ruth C.), Panagiotakos, D. B. (Demosthenes B.), Karakatsani, A. (Anna), Trichopoulou, A. (Antonia), Kuhn, T. (Tilman), Grobbee, D. E. (Diederick E.), Barrett-Connor, E. (Elizabeth), van Schoor, N. (Natasja), Boeing, H. (Heiner), Overvad, K. (Kim), Kauhanen, J. (Jussi), Wareham, N. (Nick), Langenberg, C. (Claudia), Forouhi, N. (Nita), Wennberg, M. (Maria), Despres, J.-P. (Jean-Pierre), Cushman, M. (Mary), Cooper, J. A. (Jackie A.), Rodriguez, C. J. (Carlos J.), Sakurai, M. (Masaru), Shaw, J. E. (Jonathan E.), Knuiman, M. (Matthew), Voortman, T. (Trudy), Meisinger, C. (Christa), Tjonneland, A. (Anne), Brenner, H. (Hermann), Palmieri, L. (Luigi), Dallongeville, J. (Jean), Brunner, E. J. (Eric J.), Assmann, G. (Gerd), Trevisan, M. (Maurizio), Gillum, R. F. (Richard F.), Ford, I. (Ian), Sattar, N. (Naveed), Lazo, M. (Mariana), Thompson, S. G. (Simon G.), Ferrari, P. (Pietro), Leon, D. A. (David A.), Smith, G. D. (George Davey), Peto, R. (Richard), Jackson, R. (Rod), Banks, E. (Emily), Di Angelantonio, E. (Emanuele), Danesh, J. (John), Wood, A. M. (Angela M.), Kaptoge, S. (Stephen), Butterworth, A. S. (Adam S.), Willeit, P. (Peter), Warnakula, S. (Samantha), Bolton, T. (Thomas), Paige, E. (Ellie), Paul, D. S. (Dirk S.), Sweeting, M. (Michael), Burgess, S. (Stephen), Bell, S. (Steven), Astle, W. (William), Stevens, D. (David), Koulman, A. (Albert), Selmer, R. M. (Randi M.), Verschuren, W. M. (W. M. Monique), Sato, S. (Shinichi), Njolstad, I. (Inger), Woodward, M. (Mark), Salomaa, V. (Veikko), Nordestgaard, B. G. (Borge G.), Yeap, B. B. (Bu B.), Fletcher, A. (Astrid), Melander, O. (Olle), Kuller, L. H. (Lewis H.), Balkau, B. (Beverley), Marmot, M. (Michael), Koenig, W. (Wolfgang), Casiglia, E. (Edoardo), Cooper, C. (Cyrus), Arndt, V. (Volker), Franco, O. H. (Oscar H.), Wennberg, P. (Patrik), Gallacher, J. (John), de la Camara, A. G. (Agustin Gomez), Volzke, H. (Henry), Dahm, C. C. (Christina C.), Dale, C. E. (Caroline E.), Bergmann, M. M. (Manuela M.), Crespo, C. J. (Carlos J.), van der Schouw, Y. T. (Yvonne T.), Kaaks, R. (Rudolf), Simons, L. A. (Leon A.), Lagiou, P. (Pagona), Schoufour, J. D. (Josje D.), Boer, J. M. (Jolanda M. A.), Key, T. J. (Timothy J.), Rodriguez, B. (Beatriz), Moreno-Iribas, C. (Conchi), Davidson, K. W. (Karina W.), Taylor, J. O. (James O.), Sacerdote, C. (Carlotta), Wallace, R. B. (Robert B.), Quiros, J. R. (J. Ramon), Tumino, R. (Rosario), Blazer, D. G. (Dan G., II), Linneberg, A. (Allan), Daimon, M. (Makoto), Panico, S. (Salvatore), Howard, B. (Barbara), Skeie, G. (Guri), Strandberg, T. (Timo), Weiderpass, E. (Elisabete), Nietert, P. J. (Paul J.), Psaty, B. M. (Bruce M.), Kromhout, D. (Daan), Salamanca-Fernandez, E. (Elena), Kiechl, S. (Stefan), Krumholz, H. M. (Harlan M.), Grioni, S. (Sara), Palli, D. (Domenico), Huerta, J. M. (Jose M.), Price, J. (Jackie), Sundstrom, J. (Johan), Arriola, L. (Larraitz), Arima, H. (Hisatomi), Travis, R. C. (Ruth C.), Panagiotakos, D. B. (Demosthenes B.), Karakatsani, A. (Anna), Trichopoulou, A. (Antonia), Kuhn, T. (Tilman), Grobbee, D. E. (Diederick E.), Barrett-Connor, E. (Elizabeth), van Schoor, N. (Natasja), Boeing, H. (Heiner), Overvad, K. (Kim), Kauhanen, J. (Jussi), Wareham, N. (Nick), Langenberg, C. (Claudia), Forouhi, N. (Nita), Wennberg, M. (Maria), Despres, J.-P. (Jean-Pierre), Cushman, M. (Mary), Cooper, J. A. (Jackie A.), Rodriguez, C. J. (Carlos J.), Sakurai, M. (Masaru), Shaw, J. E. (Jonathan E.), Knuiman, M. (Matthew), Voortman, T. (Trudy), Meisinger, C. (Christa), Tjonneland, A. (Anne), Brenner, H. (Hermann), Palmieri, L. (Luigi), Dallongeville, J. (Jean), Brunner, E. J. (Eric J.), Assmann, G. (Gerd), Trevisan, M. (Maurizio), Gillum, R. F. (Richard F.), Ford, I. (Ian), Sattar, N. (Naveed), Lazo, M. (Mariana), Thompson, S. G. (Simon G.), Ferrari, P. (Pietro), Leon, D. A. (David A.), Smith, G. D. (George Davey), Peto, R. (Richard), Jackson, R. (Rod), Banks, E. (Emily), Di Angelantonio, E. (Emanuele), and Danesh, J. (John)
Abstract: Background: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. Methods: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose–response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12·5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5·6 years [5th–95th percentile 1·04–13·5]) from 71 011 participants from 37 studies. Findings: In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5·4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality ris
Published: 2018

18. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Author: Wu, L. (Lang), Shi, W. (Wei), Long, J. (Jirong), Guo, X. (Xingyi), Michailidou, K. (Kyriaki), Beesley, J. (Jonathan), Bolla, M. K. (Manjeet K.), Shu, X.-O. (Xiao-Ou), Lu, Y. (Yingchang), Cai, Q. (Qiuyin), Al-Ejeh, F. (Fares), Rozali, E. (Esdy), Wang, Q. (Qin), Dennis, J. (Joe), Li, B. (Bingshan), Zeng, C. (Chenjie), Feng, H. (Helian), Gusev, A. (Alexander), Barfield, R. T. (Richard T.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Auer, P. L. (Paul L.), Barrdahl, M. (Myrto), Baynes, C. (Caroline), Beckmann, M. W. (Matthias W.), Benitez, J. (Javier), Bermisheva, M. (Marina), Blomqvist, C. (Carl), Bogdanova, N. V. (Natalia V.), Bojesen, S. E. (Stig E.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brinton, L. (Louise), Broberg, P. (Per), Brucker, S. Y. (Sara Y.), Burwinkel, B. (Barbara), Caldes, T. (Trinidad), Canzian, F. (Federico), Carter, B. D. (Brian D.), Castelao, J. E. (J. Esteban), Chang-Claude, J. (Jenny), Chen, X. (Xiaoqing), Cheng, T. D. (Ting-Yuan David), Christiansen, H. (Hans), Clarke, C. L. (Christine L.), Collee, M. (Margriet), Cornelissen, S. (Sten), Couch, F. J. (Fergus J.), Cox, D. (David), Cox, A. (Angela), Cross, S. S. (Simon S.), Cunningham, J. M. (Julie M.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Doheny, K. F. (Kimberly F.), Dork, T. (Thilo), dos-Santos-Silva, I. (Isabel), Dumont, M. (Martine), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Eilber, U. (Ursula), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Eriksson, M. (Mikael), Fachal, L. (Laura), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flesch-Janys, D. (Dieter), Fletcher, O. (Olivia), Flyger, H. (Henrik), Fritschi, L. (Lin), Gabrielson, M. (Marike), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Closas, M. (Montserrat), Gaudet, M. M. (Mia M.), Ghoussaini, M. (Maya), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hallberg, E. (Emily), Hamann, U. (Ute), Harrington, P. (Patricia), Hein, A. (Alexander), Hicks, B. (Belynda), Hillemanns, P. (Peter), Hollestelle, A. (Antoinette), Hoover, R. N. (Robert N.), Hopper, J. L. (John L.), Huang, G. (Guanmengqian), Humphreys, K. (Keith), Hunter, D. J. (David J.), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Johnson, N. (Nichola), Jones, K. (Kristine), Jones, M. E. (Michael E.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kerin, M. J. (Michael J.), Khusnutdinova, E. (Elza), Kosma, V.-M. (Veli-Matti), Kristensen, V. N. (Vessela N.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindstrom, S. (Sara), Lissowska, J. (Jolanta), Lo, W.-Y. (Wing-Yee), Loibl, S. (Sibylle), Lubinski, J. (Jan), Luccarini, C. (Craig), Lux, M. P. (Michael P.), MacInnis, R. J. (Robert J.), Maishman, T. (Tom), Kostovska, I. M. (Ivana Maleva), Mannermaa, A. (Arto), Manson, J. E. (Joann E.), Margolin, S. (Sara), Mavroudis, D. (Dimitrios), Meijers-Heijboer, H. (Hanne), Meindl, A. (Alfons), Menon, U. (Usha), Meyer, J. (Jeffery), Mulligan, A. M. (Anna Marie), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Neven, P. (Patrick), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Olopade, O. I. (Olufunmilayo I.), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Prentice, R. (Ross), Presneau, N. (Nadege), Pylkäs, K. (Katri), Rack, B. (Brigitte), Radice, P. (Paolo), Rahman, N. (Nazneen), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Rhenius, V. (Valerie), Romero, A. (Atocha), Romm, J. (Jane), Rudolph, A. (Anja), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Scott, R. J. (Rodney J.), Scott, C. G. (Christopher G.), Seal, S. (Sheila), Shah, M. (Mitul), Shrubsole, M. J. (Martha J.), Smeets, A. (Ann), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stone, J. (Jennifer), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. (William), Taylor, J. A. (Jack A.), Terry, M. B. (Mary Beth), Tessier, D. C. (Daniel C.), Thomas, A. (Abigail), Thone, K. (Kathrin), Tollenaar, R. A. (Rob A. E. M.), Torres, D. (Diana), Truong, T. (Therese), Untch, M. (Michael), Vachon, C. (Celine), Van den Berg, D. (David), Vincent, D. (Daniel), Waisfisz, Q. (Quinten), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Whittemore, A. S. (Alice S.), Wildiers, H. (Hans), Willett, W. C. (Walter C.), Winqvist, R. (Robert), Wolk, A. (Alicja), Xia, L. (Lucy), Yang, X. R. (Xiaohong R.), Ziogas, A. (Argyrios), Ziv, E. (Elad), Dunning, A. M. (Alison M.), Pharoah, P. D. (Paul D. P.), Simard, J. (Jacques), Milne, R. L. (Roger L.), Edwards, S. L. (Stacey L.), Kraft, P. (Peter), Easton, D. F. (Douglas F.), Chenevix-Trench, G. (Georgia), Zheng, W. (Wei), Wu, L. (Lang), Shi, W. (Wei), Long, J. (Jirong), Guo, X. (Xingyi), Michailidou, K. (Kyriaki), Beesley, J. (Jonathan), Bolla, M. K. (Manjeet K.), Shu, X.-O. (Xiao-Ou), Lu, Y. (Yingchang), Cai, Q. (Qiuyin), Al-Ejeh, F. (Fares), Rozali, E. (Esdy), Wang, Q. (Qin), Dennis, J. (Joe), Li, B. (Bingshan), Zeng, C. (Chenjie), Feng, H. (Helian), Gusev, A. (Alexander), Barfield, R. T. (Richard T.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Auer, P. L. (Paul L.), Barrdahl, M. (Myrto), Baynes, C. (Caroline), Beckmann, M. W. (Matthias W.), Benitez, J. (Javier), Bermisheva, M. (Marina), Blomqvist, C. (Carl), Bogdanova, N. V. (Natalia V.), Bojesen, S. E. (Stig E.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brinton, L. (Louise), Broberg, P. (Per), Brucker, S. Y. (Sara Y.), Burwinkel, B. (Barbara), Caldes, T. (Trinidad), Canzian, F. (Federico), Carter, B. D. (Brian D.), Castelao, J. E. (J. Esteban), Chang-Claude, J. (Jenny), Chen, X. (Xiaoqing), Cheng, T. D. (Ting-Yuan David), Christiansen, H. (Hans), Clarke, C. L. (Christine L.), Collee, M. (Margriet), Cornelissen, S. (Sten), Couch, F. J. (Fergus J.), Cox, D. (David), Cox, A. (Angela), Cross, S. S. (Simon S.), Cunningham, J. M. (Julie M.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Doheny, K. F. (Kimberly F.), Dork, T. (Thilo), dos-Santos-Silva, I. (Isabel), Dumont, M. (Martine), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Eilber, U. (Ursula), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Eriksson, M. (Mikael), Fachal, L. (Laura), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flesch-Janys, D. (Dieter), Fletcher, O. (Olivia), Flyger, H. (Henrik), Fritschi, L. (Lin), Gabrielson, M. (Marike), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Closas, M. (Montserrat), Gaudet, M. M. (Mia M.), Ghoussaini, M. (Maya), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hallberg, E. (Emily), Hamann, U. (Ute), Harrington, P. (Patricia), Hein, A. (Alexander), Hicks, B. (Belynda), Hillemanns, P. (Peter), Hollestelle, A. (Antoinette), Hoover, R. N. (Robert N.), Hopper, J. L. (John L.), Huang, G. (Guanmengqian), Humphreys, K. (Keith), Hunter, D. J. (David J.), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Johnson, N. (Nichola), Jones, K. (Kristine), Jones, M. E. (Michael E.), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kerin, M. J. (Michael J.), Khusnutdinova, E. (Elza), Kosma, V.-M. (Veli-Matti), Kristensen, V. N. (Vessela N.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindstrom, S. (Sara), Lissowska, J. (Jolanta), Lo, W.-Y. (Wing-Yee), Loibl, S. (Sibylle), Lubinski, J. (Jan), Luccarini, C. (Craig), Lux, M. P. (Michael P.), MacInnis, R. J. (Robert J.), Maishman, T. (Tom), Kostovska, I. M. (Ivana Maleva), Mannermaa, A. (Arto), Manson, J. E. (Joann E.), Margolin, S. (Sara), Mavroudis, D. (Dimitrios), Meijers-Heijboer, H. (Hanne), Meindl, A. (Alfons), Menon, U. (Usha), Meyer, J. (Jeffery), Mulligan, A. M. (Anna Marie), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Neven, P. (Patrick), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Olopade, O. I. (Olufunmilayo I.), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Prentice, R. (Ross), Presneau, N. (Nadege), Pylkäs, K. (Katri), Rack, B. (Brigitte), Radice, P. (Paolo), Rahman, N. (Nazneen), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Rhenius, V. (Valerie), Romero, A. (Atocha), Romm, J. (Jane), Rudolph, A. (Anja), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Scott, R. J. (Rodney J.), Scott, C. G. (Christopher G.), Seal, S. (Sheila), Shah, M. (Mitul), Shrubsole, M. J. (Martha J.), Smeets, A. (Ann), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stone, J. (Jennifer), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. (William), Taylor, J. A. (Jack A.), Terry, M. B. (Mary Beth), Tessier, D. C. (Daniel C.), Thomas, A. (Abigail), Thone, K. (Kathrin), Tollenaar, R. A. (Rob A. E. M.), Torres, D. (Diana), Truong, T. (Therese), Untch, M. (Michael), Vachon, C. (Celine), Van den Berg, D. (David), Vincent, D. (Daniel), Waisfisz, Q. (Quinten), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Whittemore, A. S. (Alice S.), Wildiers, H. (Hans), Willett, W. C. (Walter C.), Winqvist, R. (Robert), Wolk, A. (Alicja), Xia, L. (Lucy), Yang, X. R. (Xiaohong R.), Ziogas, A. (Argyrios), Ziv, E. (Elad), Dunning, A. M. (Alison M.), Pharoah, P. D. (Paul D. P.), Simard, J. (Jacques), Milne, R. L. (Roger L.), Edwards, S. L. (Stacey L.), Kraft, P. (Peter), Easton, D. F. (Douglas F.), Chenevix-Trench, G. (Georgia), and Zheng, W. (Wei)
Abstract: The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue Expression Project to establish genetic models to predict gene expression in breast tissue and evaluated model performance using data from The Cancer Genome Atlas. Of the 8,597 genes evaluated, significant associations were identified for 48 at a Bonferroni-corrected threshold of P < 5.82 × 10−6, including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology.
Published: 2018

19. Body mass index and breast cancer survival:a Mendelian randomization analysis

Author: Guo, Q. (Qi), Burgess, S. (Stephen), Turman, C. (Constance), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Lush, M. (Michael), Abraham, J. (Jean), Aittomaki, K. (Kristiina), Andrulis, I. L. (Irene L.), Apicella, C. (Carmel), Arndt, V. (Volker), Barrdahl, M. (Myrto), Benitez, J. (Javier), Berg, C. D. (Christine D.), Blomqvist, C. (Carl), Bojesen, S. E. (Stig E.), Bonanni, B. (Bernardo), Brand, J. S. (Judith S.), Brenner, H. (Hermann), Broeks, A. (Annegien), Burwinkel, B. (Barbara), Caldas, C. (Carlos), Campa, D. (Daniele), Canzian, F. (Federico), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chin, S.-F. (Suet-Feung), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Cybulski, C. (Cezary), Czene, K. (Kamila), Darabi, H. (Hatef), Devilee, P. (Peter), Diver, W. R. (W. Ryan), Dunning, A. M. (Alison M.), Earl, H. M. (Helena M.), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eriksson, M. (Mikael), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flesch-Janys, D. (Dieter), Flyger, H. (Henrik), Gapstur, S. M. (Susan M.), Gaudet, M. M. (Mia M.), Giles, G. G. (Graham G.), Glendon, G. (Gord), Grip, M. (Mervi), Gronwald, J. (Jacek), Haeberle, L. (Lothar), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hamann, U. (Ute), Hankinson, S. (Susan), Hartikainen, J. M. (Jaana M.), Hein, A. (Alexander), Hiller, L. (Louise), Hogervorst, F. B. (Frans B.), Holleczek, B. (Bernd), Hooning, M. J. (Maartje J.), Hoover, R. N. (Robert N.), Humphreys, K. (Keith), Hunter, D. J. (David J.), Husing, A. (Anika), Jakubowska, A. (Anna), Jukkola-Vuorinen, A. (Arja), Kaaks, R. (Rudolf), Kabisch, M. (Maria), Kataja, V. (Vesa), Knight, J. A. (Julia A.), Koppert, L. B. (Linetta B.), Kosma, V.-M. (Veli-Matti), Kristensen, V. N. (Vessela N.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindblom, A. (Annika), Lindstrom, S. (Sara), Lissowska, J. (Jolanta), Lubinski, J. (Jan), Machiela, M. J. (Mitchell J.), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Marme, F. (Federik), Martens, J. W. (John W. M.), McLean, C. (Catriona), Menendez, P. (Primitiva), Milne, R. L. (Roger L.), Mulligan, A. M. (Anna Marie), Muranen, T. A. (Taru A.), Nevanlinna, H. (Heli), Neven, P. (Patrick), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Olson, J. E. (Janet E.), Perez, J. I. (Jose I. A.), Peterlongo, P. (Paolo), Phillips, K.-A. (Kelly-Anne), Poole, C. J. (Christopher J.), Pylkas, K. (Katri), Radice, P. (Paolo), Rahman, N. (Nazneen), Rudiger, T. (Thomas), Rudolph, A. (Anja), Sawyer, E. J. (Elinor J.), Schumacher, F. (Fredrick), Seibold, P. (Petra), Seynaeve, C. (Caroline), Shah, M. (Mitul), Smeets, A. (Ann), Southey, M. C. (Melissa C.), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Tsimiklis, H. (Helen), Ulmer, H.-U. (Hans-Ulrich), Vachon, C. (Celine), van den Ouweland, A. M. (Ans M. W.), Van't Veer, L. J. (Laura J.), Wildiers, H. (Hans), Willett, W. (Walter), Winqvist, R. (Robert), Zamora, M. P. (M. Pilar), Chenevix-Trench, G. (Georgia), Dork, T. (Thilo), Easton, D. F. (Douglas F.), Garcia-Closas, M. (Montserrat), Kraft, P. (Peter), Hopper, J. L. (John L.), Zheng, W. (Wei), Schmidt, M. K. (Marjanka K.), and Pharoah, P. D. (Paul D. P.)
Subjects: Mendelian randomization, breast cancer survival, body mass index, epidemiology, genetics
Abstract: Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. Methods: We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis. Results: BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01–1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89–1.13, P = 0.95). Conclusions: Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.
Published: 2017

20. Body mass index and breast cancer survival

Author: Guo, Q. (Qi), Burgess, S. (Stephen), Turman, C. (Constance), Bolla, M.K. (Manjeet K.), Wang, Q. (Qin), Lush, M. (Michael), Abraham, J. (Jean), Aittomäki, K. (Kristiina), Andrulis, I.L. (Irene), Apicella, C. (Carmel), Arndt, V. (Volker), Barrdahl, M. (Myrto), Benítez, J. (Javier), Berg, C.D. (Christine), Blomqvist, C. (Carl), Bojesen, S.E. (Stig), Bonnani, B. (Bernardo), Brand, J.S. (Judith S.), Brenner, H. (Hermann), Broeks, A. (Annegien), Burwinkel, B. (Barbara), Caldas, C. (Carlos), Campa, D. (Daniele), Canzian, F. (Federico), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen), Chin, S.-F. (Suet-Feung), Couch, F.J. (Fergus J.), Cox, A. (Angela), Cross, S.S. (Simon), Cybulski, C. (Cezary), Czene, K. (Kamila), Darabi, H. (Hatef), Devilee, P. (Peter), Diver, W.R. (Ryan), Dunning, A.M. (Alison), Earl, H. (Helena), Eccles, D.M. (Diana M.), Ekici, A.B. (Arif B.), Eriksson, M. (Mats), Evans, D.G. (D Gareth), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Flesch-Janys, D. (Dieter), Flyger, H. (Henrik), Gapstur, S.M. (Susan M.), Gaudet, M.M. (Mia M.), Giles, G.G. (Graham G.), Glendon, G. (Gord), Grip, M. (Mervi), Gronwald, J. (Jacek), Haeberle, L. (Lothar), Haiman, C.A. (Christopher), Hall, P. (Per), Hamann, U. (Ute), Hankinson, S.E. (Susan), Hartikainen, J.M. (Jaana M.), Hein, A. (Alexander), Hiller, L. (Louise), Hogervorst, F.B. (Frans B.), Holleczek, B. (B.), Hooning, M.J. (Maartje), Hoover, R.N. (Robert), Humphreys, K. (Keith), Hunter, D. (David), Hüsing, A. (Anika), Jakubowska, A. (Anna), Jukkola-Vuorinen, A. (Arja), Kaaks, R. (Rudolf), Kabisch, M. (Maria), Kataja, V. (Vesa), Knight, J.A. (Julia), Koppert, L.B. (Linetta), Kosma, V-M. (Veli-Matti), Kristensen, V.N. (Vessela N.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindblom, A. (Annika), Lindström, S. (Sara), Lissowska, J. (Jolanta), Lubinski, J. (Jan), Machiela, M.J. (Mitchell J.), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Marme, F. (Federik), Martens, J.W.M. (John), McLean, C.A. (Catriona Ann), Menéndez, P. (Primitiva), Milne, R.L. (Roger), Mulligan, A.-M. (Anna-Marie), Muranen, T.A. (Taru A.), Nevanlinna, H. (Heli), Neven, P. (Patrick), Nielsen, S.F. (Sune F.), Nordestgaard, B.G. (Børge), Olson, J.E. (Janet), Perez, J.I.A. (Jose Ignacio Arias), Peterlongo, P. (Paolo), Phillips, K.-A. (Kelly-Anne), Poole, C.J. (Christopher J.), Pykäs, K. (Katri), Radice, P. (Paolo), Rahman, N. (Nazneen), Rud̈iger, T. (Thomas), Rudolph, A. (Anja), Sawyer, E.J. (Elinor), Schumacher, F.R. (Fredrick R), Seibold, P. (Petra), Seynaeve, C.M. (Caroline), Shah, M. (Mitul), Smeets, A. (Ann), Southey, M.C. (Melissa C.), Tollenaar, R.A.E.M. (Rob), Tomlinson, I.P. (Ian), Tsimiklis, H. (Helen), Ulmer, H.U. (Hans), Vachon, C. (Celine), Ouweland, A.M.W. (Ans) van den, Veer, L.J. (Laura) van 't, Wildiers, H. (Hans), Willett, W.C. (Walter C.), Winqvist, R. (Robert), Zamora, M.P. (Pilar), Chenevix-Trench, G. (Georgia), Dörk, T. (Thilo), Easton, D.F. (Douglas), García-Closas, M. (Montserrat), Kraft, P. (Peter), Hopper, J.L. (John), Zheng, W. (Wei), Schmidt, M.K. (Marjanka), Pharoah, P.D.P. (Paul), Guo, Q. (Qi), Burgess, S. (Stephen), Turman, C. (Constance), Bolla, M.K. (Manjeet K.), Wang, Q. (Qin), Lush, M. (Michael), Abraham, J. (Jean), Aittomäki, K. (Kristiina), Andrulis, I.L. (Irene), Apicella, C. (Carmel), Arndt, V. (Volker), Barrdahl, M. (Myrto), Benítez, J. (Javier), Berg, C.D. (Christine), Blomqvist, C. (Carl), Bojesen, S.E. (Stig), Bonnani, B. (Bernardo), Brand, J.S. (Judith S.), Brenner, H. (Hermann), Broeks, A. (Annegien), Burwinkel, B. (Barbara), Caldas, C. (Carlos), Campa, D. (Daniele), Canzian, F. (Federico), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen), Chin, S.-F. (Suet-Feung), Couch, F.J. (Fergus J.), Cox, A. (Angela), Cross, S.S. (Simon), Cybulski, C. (Cezary), Czene, K. (Kamila), Darabi, H. (Hatef), Devilee, P. (Peter), Diver, W.R. (Ryan), Dunning, A.M. (Alison), Earl, H. (Helena), Eccles, D.M. (Diana M.), Ekici, A.B. (Arif B.), Eriksson, M. (Mats), Evans, D.G. (D Gareth), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Flesch-Janys, D. (Dieter), Flyger, H. (Henrik), Gapstur, S.M. (Susan M.), Gaudet, M.M. (Mia M.), Giles, G.G. (Graham G.), Glendon, G. (Gord), Grip, M. (Mervi), Gronwald, J. (Jacek), Haeberle, L. (Lothar), Haiman, C.A. (Christopher), Hall, P. (Per), Hamann, U. (Ute), Hankinson, S.E. (Susan), Hartikainen, J.M. (Jaana M.), Hein, A. (Alexander), Hiller, L. (Louise), Hogervorst, F.B. (Frans B.), Holleczek, B. (B.), Hooning, M.J. (Maartje), Hoover, R.N. (Robert), Humphreys, K. (Keith), Hunter, D. (David), Hüsing, A. (Anika), Jakubowska, A. (Anna), Jukkola-Vuorinen, A. (Arja), Kaaks, R. (Rudolf), Kabisch, M. (Maria), Kataja, V. (Vesa), Knight, J.A. (Julia), Koppert, L.B. (Linetta), Kosma, V-M. (Veli-Matti), Kristensen, V.N. (Vessela N.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindblom, A. (Annika), Lindström, S. (Sara), Lissowska, J. (Jolanta), Lubinski, J. (Jan), Machiela, M.J. (Mitchell J.), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Marme, F. (Federik), Martens, J.W.M. (John), McLean, C.A. (Catriona Ann), Menéndez, P. (Primitiva), Milne, R.L. (Roger), Mulligan, A.-M. (Anna-Marie), Muranen, T.A. (Taru A.), Nevanlinna, H. (Heli), Neven, P. (Patrick), Nielsen, S.F. (Sune F.), Nordestgaard, B.G. (Børge), Olson, J.E. (Janet), Perez, J.I.A. (Jose Ignacio Arias), Peterlongo, P. (Paolo), Phillips, K.-A. (Kelly-Anne), Poole, C.J. (Christopher J.), Pykäs, K. (Katri), Radice, P. (Paolo), Rahman, N. (Nazneen), Rud̈iger, T. (Thomas), Rudolph, A. (Anja), Sawyer, E.J. (Elinor), Schumacher, F.R. (Fredrick R), Seibold, P. (Petra), Seynaeve, C.M. (Caroline), Shah, M. (Mitul), Smeets, A. (Ann), Southey, M.C. (Melissa C.), Tollenaar, R.A.E.M. (Rob), Tomlinson, I.P. (Ian), Tsimiklis, H. (Helen), Ulmer, H.U. (Hans), Vachon, C. (Celine), Ouweland, A.M.W. (Ans) van den, Veer, L.J. (Laura) van 't, Wildiers, H. (Hans), Willett, W.C. (Walter C.), Winqvist, R. (Robert), Zamora, M.P. (Pilar), Chenevix-Trench, G. (Georgia), Dörk, T. (Thilo), Easton, D.F. (Douglas), García-Closas, M. (Montserrat), Kraft, P. (Peter), Hopper, J.L. (John), Zheng, W. (Wei), Schmidt, M.K. (Marjanka), and Pharoah, P.D.P. (Paul)
Abstract: __Background:__ There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. __Methods:__ We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis. __Results:__
Published: 2017
Full Text: View/download PDF

21. Worldwide trends in blood pressure from 1975 to 2015:a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

Author: Zhou, B. (Bin), Bentham, J. (James), Di Cesare, M. (Mariachiara), Bixby, H. (Honor), Danaei, G. (Goodarz), Cowan, M. J. (Melanie J.), Paciorek, C. J. (Christopher J.), Singh, G. (Gitanjali), Hajifathalian, K. (Kaveh), Bennett, J. E. (James E.), Taddei, C. (Cristina), Bilano, V. (Ver), Carrillo-Larco, R. M. (Rodrigo M.), Djalalinia, S. (Shirin), Khatibzadeh, S. (Shahab), Lugero, C. (Charles), Peykari, N. (Niloofar), Zhang, W. Z. (Wan Zhu), Lu, Y. (Yuan), Stevens, G. A. (Gretchen A.), Riley, L. M. (Leanne M.), Bovet, P. (Pascal), Elliott, P. (Paul), Gu, D. (Dongfeng), Ikeda, N. (Nayu), Jackson, R. T. (Rod T.), Joffres, M. (Michel), Kengne, A. P. (Andre Pascal), Laatikainen, T. (Tiina), Lam, T. H. (Tai Hing), Laxmaiah, A. (Avula), Liu, J. (Jing), Miranda, J. J. (J. Jaime), Mondo, C. K. (Charles K.), Neuhauser, H. K. (Hannelore K.), Sundstrom, J. (Johan), Smeeth, L. (Liam), Soric, M. (Maroje), Woodward, M. (Mark), Ezzati, M. (Majid), Abarca-Gomez, L. (Leandra), Abdeen, Z. A. (Ziad A.), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Afsana, K. (Kaosar), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (Wolfgang), Al Raddadi, R. (Rajaa), Al Woyatan, R. (Rihab), Ali, M. M. (Mohamed M.), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Angquist, L. (Lars), Anjana, R. M. (Ranjit Mohan), Ansong, D. (Daniel), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Aryal, K. (Krishna), Arveiler, D. (Dominique), Assah, F. K. (Felix K.), Assuncao, M. C. (Maria Cecilia F.), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Babu, B. V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Barros, A. J. (Aluisio J. D.), Barros, M. V. (Mauro V.), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benson, L. S. (Lowell S.), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bikbov, M. (Mukharram), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjokelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boeing, H. (Heiner), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bongard, V. (Vanina), Braeckman, L. (Lutgart), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bueno-de-Mesquita, H. B. (H. B. (as)), Bugge, A. (Anna), Burns, C. (Con), Bursztyn, M. (Michael), de Leon, A. C. (Antonio Cabrera), Cameron, C. (Christine), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carlsson, A. C. (Axel C.), Carvalho, M. J. (Maria J.), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A. W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H. K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Dekkaki, I. C. (Imane Cherkaoui), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F. (Frank), Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Cyrus), Cooper, R. (Rachel), Coppinger, T. C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C. L. (Cora L.), Crujeiras, A. B. (Ana B.), Cruz, J. J. (Juan J.), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), De Backer, G. (Guy), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Dehghan, A. (Abbas), Delisle, H. (Helene), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A. F. (Augusto F.), Dias-da-Costa, J. S. (Juvenal Soares), Diaz, A. (Alejandro), Dickerson, T. T. (Ty T.), Do, H. T. (Ha T. P.), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doering, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dulskiene, V. (Virginija), Dzakula, A. (Aleksandar), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Ellert, U. (Ute), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Pena, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Fischer, K. (Krista), Foeger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S. P. (Stephen P.), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fuchs, F. D. (Flavio D.), Fuchs, S. C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gareta, D. (Dickman), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gavrila, D. (Diana), Geleijnse, J. M. (Johanna M.), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Goldsmith, R. A. (Rebecca A.), Goncalves, H. (Helen), Gonzalez Gross, M. (Marcela), Gonzalez Rivas, J. P. (Juan P.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Grajda, A. (Aneta), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Guan, O. P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A. L. (Andre L.), Gulliford, M. C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Gupta, P. C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Hadaegh, F. (Farzad), Halkjaer, J. (Jytte), Hambleton, I. R. (Ian R.), Hardy, R. (Rebecca), Harikumar, R. (Rachakulla), Hata, J. (Jun), Hayes, A. J. (Alison J.), He, J. (Jiang), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Hernandez Cadena, L. (Leticia), . (), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I. T. (Ilpo Tapani), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Dinc, G. H. (Gonul Horasan), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Hu, Y. (Yonghua), Maria Huerta, J. (Jose), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (M. Mohsen), Ikram, M. A. (M. Arfan), Irazola, V. E. (Vilma E.), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jafar, T. (Tazeen), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C. Q. (Chao Qiang), Johansson, M. (Mattias), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Juresa, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kasaeian, A. (Amir), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Boker, L. K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H. C. (Han C. G.), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klumbiene, J. (Jurate), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H. S. (Herculina S.), Kubinova, R. (Ruzena), Kuciene, R. (Renata), Kuh, D. (Diana), Kujala, U. M. (Urho M.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R. K. (R. Krishna), Kurjata, P. (Pawel), Kusuma, Y. S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Lachat, C. (Carl), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L. E. (Lars E.), Le, T. D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Lekhraj, R. (Rampal), Leon-Munoz, L. M. (Luz M.), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M. (M.), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Lorbeer, R. (Roberto), Lotufo, P. A. (Paulo A.), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G. L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Majer, M. (Marjeta), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K. M. (Kodavanti Mallikharjuna), Malyutina, S. (Sofia), Manios, Y. (Yannis), Mann, J. I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martorell, R. (Reynaldo), Mathiesen, E. B. (Ellisiv B.), Matijasevich, A. (Alicia), Matsha, T. E. (Tandi E.), Mbanya, J. C. (Jean Claude N.), Posso, A. J. (Anselmo J. Mc Donald), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McNulty, B. A. (Breige A.), Khir, A. S. (Amir Sharifuddin Md), Mediene-Benchekor, S. (Sounnia), Medzioniene, J. (Jurate), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Meshram, I. I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Mikkel, K. (Kairit), Miller, J. C. (Jody C.), Francisco Miquel, J. (Juan), Jaime Miranda, J. (J.), Misigoj-Durakovic, M. (Marjeta), Mohamed, M. K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M. F. (Muhammad Fadhli Mohd), Moller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Monyeki, K. D. (Kotsedi Daniel K.), Moreira, L. B. (Leila B.), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Muiesan, M. L. (Maria L.), Mueller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Musil, V. (Vera), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Nakamura, H. (Harunobu), Namsna, J. (Jana), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Narake, S. (Sameer), Maria Navarrete-Munoz, E. (Eva), Ndiaye, N. C. (Ndeye Coumba), Neal, W. A. (William A.), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noorbala, A. A. (Ahmad Ali), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olinto, M. T. (Maria Teresa A.), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ordunez, P. (Pedro), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Otero, J. A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Papandreou, D. (Dimitrios), Parnell, W. R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M. S. (Mangesh S.), Peer, N. (Nasheeta), Peeters, P. H. (Petra H.), Peixoto, S. V. (Sergio Viana), Pelletier, C. (Catherine), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Marina Perez, R. (Rosa), Peters, A. (Annette), Petkeviciene, J. (Janina), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, L. (Lorenza), Pitakaka, F. (Freda), Plans-Rubio, P. (Pedro), Polakowska, M. (Maria), Polasek, O. (Ozren), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Pourshams, A. (Akram), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J. F. (Jacqueline F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R. F. (Radwan F.), Qorbani, M. (Mostafa), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahfuzar), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S. R. (Sudha Ramachandra), Ramos, E. (Elisabete), Rampal, S. (Sanjay), Rangel Reina, D. A. (Daniel A.), Rasmussen, F. (Finn), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Ritti-Dias, R. M. (Raphael M.), Robinson, S. M. (Sian M.), Robitaille, C. (Cynthia), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Villamizar, L. A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Sandra Ruiz-Betancourt, B. (Blanca), Russo Horimoto, A. R. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salazar Martinez, E. (Eduardo), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santos, D. (Diana), Santos, I. S. (Ina S.), dos Santos, R. N. (Renata Nunes), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Margolis, G. S. (Giselle Sarganas), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Schneider, I. J. (Ione J.), Schultsz, C. (Constance), Schutte, A. E. (Aletta E.), Sen, A. (Abhijit), Senbanjo, I. O. (Idowu O.), Sepanlou, S. G. (Sadaf G.), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjotrom, M. (Michael), Skovbjerg, S. (Sine), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smith, M. C. (Margaret C.), Snijder, M. B. (Marieke B.), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugene), Soderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Starc, G. (Gregor), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stergiou, G. S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Sun, C.-A. (Chien-An), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Tai, E. S. (E. Shyong), Tammesoo, M.-L. (Mari-Liis), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Tjonneland, A. (Anne), Tolonen, H. K. (Hanna K.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Trinh, O. T. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M. L. (Maria L.), Tynelius, P. (Per), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), van Rossem, L. (Lenie), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W. M. (W. M. Monique), Verstraeten, R. (Roosmarijn), Victora, C. G. (Cesar G.), Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W. N. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wareham, N. (Nicholas), Wederkopp, N. (Niels), Weerasekera, D. (Deepa), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, P. (Peter), Williams, E. A. (Emmanuel A.), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T. Y. (Tien Yin), Wong-McClure, R. A. (Roy A.), Woo, J. (Jean), Wu, A. G. (Aleksander Giwercman), Wu, F. C. (Frederick C.), Wu, S. L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yiallouros, P. K. (Panayiotis K.), Yoshihara, A. (Akihiro), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad F.), Zambon, S. (Sabina), Zdrojewski, T. (Tomasz), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingffeng), Zhu, D. (Dan), Zimmermann, E. (Esther), Zuniga Cisneros, J. (Julio), Zhou, B. (Bin), Bentham, J. (James), Di Cesare, M. (Mariachiara), Bixby, H. (Honor), Danaei, G. (Goodarz), Cowan, M. J. (Melanie J.), Paciorek, C. J. (Christopher J.), Singh, G. (Gitanjali), Hajifathalian, K. (Kaveh), Bennett, J. E. (James E.), Taddei, C. (Cristina), Bilano, V. (Ver), Carrillo-Larco, R. M. (Rodrigo M.), Djalalinia, S. (Shirin), Khatibzadeh, S. (Shahab), Lugero, C. (Charles), Peykari, N. (Niloofar), Zhang, W. Z. (Wan Zhu), Lu, Y. (Yuan), Stevens, G. A. (Gretchen A.), Riley, L. M. (Leanne M.), Bovet, P. (Pascal), Elliott, P. (Paul), Gu, D. (Dongfeng), Ikeda, N. (Nayu), Jackson, R. T. (Rod T.), Joffres, M. (Michel), Kengne, A. P. (Andre Pascal), Laatikainen, T. (Tiina), Lam, T. H. (Tai Hing), Laxmaiah, A. (Avula), Liu, J. (Jing), Miranda, J. J. (J. Jaime), Mondo, C. K. (Charles K.), Neuhauser, H. K. (Hannelore K.), Sundstrom, J. (Johan), Smeeth, L. (Liam), Soric, M. (Maroje), Woodward, M. (Mark), Ezzati, M. (Majid), Abarca-Gomez, L. (Leandra), Abdeen, Z. A. (Ziad A.), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Afsana, K. (Kaosar), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (Wolfgang), Al Raddadi, R. (Rajaa), Al Woyatan, R. (Rihab), Ali, M. M. (Mohamed M.), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Angquist, L. (Lars), Anjana, R. M. (Ranjit Mohan), Ansong, D. (Daniel), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Aryal, K. (Krishna), Arveiler, D. (Dominique), Assah, F. K. (Felix K.), Assuncao, M. C. (Maria Cecilia F.), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Babu, B. V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Barros, A. J. (Aluisio J. D.), Barros, M. V. (Mauro V.), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benson, L. S. (Lowell S.), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bikbov, M. (Mukharram), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjokelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boeing, H. (Heiner), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bongard, V. (Vanina), Braeckman, L. (Lutgart), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bueno-de-Mesquita, H. B. (H. B. (as)), Bugge, A. (Anna), Burns, C. (Con), Bursztyn, M. (Michael), de Leon, A. C. (Antonio Cabrera), Cameron, C. (Christine), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carlsson, A. C. (Axel C.), Carvalho, M. J. (Maria J.), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A. W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H. K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Dekkaki, I. C. (Imane Cherkaoui), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F. (Frank), Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Cyrus), Cooper, R. (Rachel), Coppinger, T. C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C. L. (Cora L.), Crujeiras, A. B. (Ana B.), Cruz, J. J. (Juan J.), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), De Backer, G. (Guy), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Dehghan, A. (Abbas), Delisle, H. (Helene), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A. F. (Augusto F.), Dias-da-Costa, J. S. (Juvenal Soares), Diaz, A. (Alejandro), Dickerson, T. T. (Ty T.), Do, H. T. (Ha T. P.), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doering, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dulskiene, V. (Virginija), Dzakula, A. (Aleksandar), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Ellert, U. (Ute), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Pena, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Fischer, K. (Krista), Foeger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S. P. (Stephen P.), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fuchs, F. D. (Flavio D.), Fuchs, S. C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gareta, D. (Dickman), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gavrila, D. (Diana), Geleijnse, J. M. (Johanna M.), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Goldsmith, R. A. (Rebecca A.), Goncalves, H. (Helen), Gonzalez Gross, M. (Marcela), Gonzalez Rivas, J. P. (Juan P.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Grajda, A. (Aneta), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Guan, O. P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A. L. (Andre L.), Gulliford, M. C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Gupta, P. C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Hadaegh, F. (Farzad), Halkjaer, J. (Jytte), Hambleton, I. R. (Ian R.), Hardy, R. (Rebecca), Harikumar, R. (Rachakulla), Hata, J. (Jun), Hayes, A. J. (Alison J.), He, J. (Jiang), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Hernandez Cadena, L. (Leticia), . (), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I. T. (Ilpo Tapani), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Dinc, G. H. (Gonul Horasan), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Hu, Y. (Yonghua), Maria Huerta, J. (Jose), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (M. Mohsen), Ikram, M. A. (M. Arfan), Irazola, V. E. (Vilma E.), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jafar, T. (Tazeen), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C. Q. (Chao Qiang), Johansson, M. (Mattias), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Juresa, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kasaeian, A. (Amir), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Boker, L. K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H. C. (Han C. G.), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klumbiene, J. (Jurate), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H. S. (Herculina S.), Kubinova, R. (Ruzena), Kuciene, R. (Renata), Kuh, D. (Diana), Kujala, U. M. (Urho M.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R. K. (R. Krishna), Kurjata, P. (Pawel), Kusuma, Y. S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Lachat, C. (Carl), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L. E. (Lars E.), Le, T. D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Lekhraj, R. (Rampal), Leon-Munoz, L. M. (Luz M.), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M. (M.), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Lorbeer, R. (Roberto), Lotufo, P. A. (Paulo A.), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G. L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Majer, M. (Marjeta), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K. M. (Kodavanti Mallikharjuna), Malyutina, S. (Sofia), Manios, Y. (Yannis), Mann, J. I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martorell, R. (Reynaldo), Mathiesen, E. B. (Ellisiv B.), Matijasevich, A. (Alicia), Matsha, T. E. (Tandi E.), Mbanya, J. C. (Jean Claude N.), Posso, A. J. (Anselmo J. Mc Donald), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McNulty, B. A. (Breige A.), Khir, A. S. (Amir Sharifuddin Md), Mediene-Benchekor, S. (Sounnia), Medzioniene, J. (Jurate), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Meshram, I. I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Mikkel, K. (Kairit), Miller, J. C. (Jody C.), Francisco Miquel, J. (Juan), Jaime Miranda, J. (J.), Misigoj-Durakovic, M. (Marjeta), Mohamed, M. K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M. F. (Muhammad Fadhli Mohd), Moller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Monyeki, K. D. (Kotsedi Daniel K.), Moreira, L. B. (Leila B.), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Muiesan, M. L. (Maria L.), Mueller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Musil, V. (Vera), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Nakamura, H. (Harunobu), Namsna, J. (Jana), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Narake, S. (Sameer), Maria Navarrete-Munoz, E. (Eva), Ndiaye, N. C. (Ndeye Coumba), Neal, W. A. (William A.), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noorbala, A. A. (Ahmad Ali), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olinto, M. T. (Maria Teresa A.), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ordunez, P. (Pedro), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Otero, J. A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Papandreou, D. (Dimitrios), Parnell, W. R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M. S. (Mangesh S.), Peer, N. (Nasheeta), Peeters, P. H. (Petra H.), Peixoto, S. V. (Sergio Viana), Pelletier, C. (Catherine), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Marina Perez, R. (Rosa), Peters, A. (Annette), Petkeviciene, J. (Janina), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, L. (Lorenza), Pitakaka, F. (Freda), Plans-Rubio, P. (Pedro), Polakowska, M. (Maria), Polasek, O. (Ozren), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Pourshams, A. (Akram), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J. F. (Jacqueline F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R. F. (Radwan F.), Qorbani, M. (Mostafa), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahfuzar), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S. R. (Sudha Ramachandra), Ramos, E. (Elisabete), Rampal, S. (Sanjay), Rangel Reina, D. A. (Daniel A.), Rasmussen, F. (Finn), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Ritti-Dias, R. M. (Raphael M.), Robinson, S. M. (Sian M.), Robitaille, C. (Cynthia), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Villamizar, L. A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Sandra Ruiz-Betancourt, B. (Blanca), Russo Horimoto, A. R. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salazar Martinez, E. (Eduardo), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santos, D. (Diana), Santos, I. S. (Ina S.), dos Santos, R. N. (Renata Nunes), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Margolis, G. S. (Giselle Sarganas), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Schneider, I. J. (Ione J.), Schultsz, C. (Constance), Schutte, A. E. (Aletta E.), Sen, A. (Abhijit), Senbanjo, I. O. (Idowu O.), Sepanlou, S. G. (Sadaf G.), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjotrom, M. (Michael), Skovbjerg, S. (Sine), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smith, M. C. (Margaret C.), Snijder, M. B. (Marieke B.), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugene), Soderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Starc, G. (Gregor), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stergiou, G. S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Sun, C.-A. (Chien-An), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Tai, E. S. (E. Shyong), Tammesoo, M.-L. (Mari-Liis), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Tjonneland, A. (Anne), Tolonen, H. K. (Hanna K.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Trinh, O. T. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M. L. (Maria L.), Tynelius, P. (Per), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), van Rossem, L. (Lenie), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W. M. (W. M. Monique), Verstraeten, R. (Roosmarijn), Victora, C. G. (Cesar G.), Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W. N. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wareham, N. (Nicholas), Wederkopp, N. (Niels), Weerasekera, D. (Deepa), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, P. (Peter), Williams, E. A. (Emmanuel A.), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T. Y. (Tien Yin), Wong-McClure, R. A. (Roy A.), Woo, J. (Jean), Wu, A. G. (Aleksander Giwercman), Wu, F. C. (Frederick C.), Wu, S. L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yiallouros, P. K. (Panayiotis K.), Yoshihara, A. (Akihiro), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad F.), Zambon, S. (Sabina), Zdrojewski, T. (Tomasz), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingffeng), Zhu, D. (Dan), Zimmermann, E. (Esther), and Zuniga Cisneros, J. (Julio)
Abstract: Background: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods: For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings: We pooled 1479 studies that had measured the blood pressures of 19.1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127.0 mm Hg (95% credible interval 125.7–128.3) in men and 122.3 mm Hg (121.0–123.6) in women; age-standardised mean diastolic blood pressure was 78.7 mm Hg (77.9–79.5) for men and 76.7 mm Hg (75.9–77.6) for women. Global age-standardised prevalence of raised blood pressure was 24.1% (21.4–27.1) in men and 20.1% (17.8–22.5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in
Published: 2017

22. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Author: Scott, R.A. (Robert), Freitag, C.M. (Christine), Li, L. (Li), Chu, A.Y. (Audrey), Surendran, P. (Praveen), Young, R. (Robin), Grarup, N. (Niels), Stancáková, A. (Alena), Chen, Y. (Yuning), Varga, T.V. (Tibor V.), Yaghootkar, H. (Hanieh), Luan, J. (Jian'An), Zhao, J.H. (Jing Hua), Willems, S.M. (Sara), Wessel, J. (Jennifer), Wang, S. (Shuai), Maruthur, N.M. (Nisa M), Michailidou, K. (Kyriaki), Pirie, A. (Ailith), Lee, S.J. (Sven) van der, Gillson, C.J. (Christopher), Al Olama, A.A. (Ali Amin), Amouyel, P. (Philippe), Arriola, L. (Larraitz), Arveiler, D. (Dominique), Aviles-Olmos, I. (Iciar), Balkau, B. (Beverley), Barricarte, A. (Aurelio), Barroso, I.E. (Inês), Garcia, S.B. (Sara Benlloch), Bis, J.C. (Joshua), Blankenberg, S. (Stefan), Boehnke, M. (Michael), Boeing, H. (Heiner), Boerwinkle, E.A. (Eric), Borecki, I.B. (Ingrid), Bork-Jensen, J. (Jette), Bowden, S. (Sarah), Caldas, C. (Carlos), Caslake, M. (Muriel), Cupples, L.A. (Adrienne), Cruchaga, C. (Carlos), Czajkowski, J. (Jacek), Hoed, M. (Marcel) den, Dunn, J.A. (Janet A.), Earl, H. (Helena), Ehret, G.B. (Georg), Ferrannini, E. (Ele), Ferrieres, J. (Jean), Foltynie, T. (Thomas), Ford, I. (Ian), Forouhi, N.G. (Nita), Gianfagna, F. (Francesco), Gonzalez, C. (Carlos), Grioni, S. (Sara), Hiller, L. (Louise), Jansson, J.H., Jørgensen, M.E. (Marit E.), Jukema, J.W. (Jan Wouter), Kaaks, R. (Rudolf), Kee, F. (Frank), Kerrison, N.D. (Nicola D.), Key, T. (Tim), Kontto, J. (Jukka), Kote-Jarai, Z., Kraja, A. (Aldi), Kuulasmaa, K. (Kari), Kuusisto, J. (Johanna), Linneberg, A. (Allan), Liu, C. (Chunyu), Marenne, G. (Gaëlle), Mohlke, K.L. (Karen), Morris, A.P. (Andrew), Muir, K.R. (K.), Müller-Nurasyid, M. (Martina), Munroe, P. (Patricia), Navarro, C. (Carmen), Nielsen, S.F. (Sune), Nilsson, P. (Peter), Nordestgaard, B.G. (Børge), Packard, C.J. (Chris J.), Palli, D. (Domenico), Panico, S. (Salvatore), Peloso, G.M. (Gina), Perola, M. (Markus), Peters, A. (Annette), Poole, C.J. (Christopher J.), Quirós, J.R., Rolandsson, O. (Olov), Sacerdote, C. (Carlotta), Salomaa, V. (Veikko), Sánchez, M.-J. (María-José), Sattar, N. (Naveed), Sharp, S.J. (Stephen), Sims, R. (Rebecca), Slimani, N. (Nadia), Smith, J.A. (Jennifer A), Thompson, D. (Deborah), Trompet, S. (Stella), Tumino, R. (Rosario), Van Der A, D.L. (Daphne L.), Schouw, Y.T. (Yvonne) van der, Virtamo, J. (Jarmo), Walker, M. (Mark), Walter, K. (Klaudia), Abraham, J.E. (Jean E.), Amundadottir, L.T. (Laufey T.), Butterworth, A.S. (Adam), Aponte, J.L. (Jennifer L), Dupuis, J. (Josée), Easton, D.F. (Douglas F.), Eeles, R. (Rosalind), Erdmann, J. (Jeanette), Franks, P.W. (Paul), Frayling, T.M. (Timothy), Hansen, T. (T.), Howson, J.M.M. (Joanna M.M.), Jorgensen, T. (Torben), Kooner, J.S. (Jaspal S.), Laakso, M. (Markku), McCarthy, M.I. (Mark), Pankow, J.S. (James), Pedersen, O. (Oluf), Riboli, E. (Elio), Rotter, J.I. (Jerome I.), Saleheen, D. (Danish), Samani, N.J. (Nilesh), Schunkert, H. (Heribert), Vollenweider, P. (Peter), O'Rahilly, S. (Stephen), Deloukas, P. (Panagiotis), Danesh, J. (John), Goodarzi, M. (Mark), Kathiresan, S. (Sekar), Meigs, J.B. (James), Ehm, M.G. (Margaret G), Wareham, N.J. (Nick), Waterworth, D. (Dawn), Scott, R.A. (Robert), Freitag, C.M. (Christine), Li, L. (Li), Chu, A.Y. (Audrey), Surendran, P. (Praveen), Young, R. (Robin), Grarup, N. (Niels), Stancáková, A. (Alena), Chen, Y. (Yuning), Varga, T.V. (Tibor V.), Yaghootkar, H. (Hanieh), Luan, J. (Jian'An), Zhao, J.H. (Jing Hua), Willems, S.M. (Sara), Wessel, J. (Jennifer), Wang, S. (Shuai), Maruthur, N.M. (Nisa M), Michailidou, K. (Kyriaki), Pirie, A. (Ailith), Lee, S.J. (Sven) van der, Gillson, C.J. (Christopher), Al Olama, A.A. (Ali Amin), Amouyel, P. (Philippe), Arriola, L. (Larraitz), Arveiler, D. (Dominique), Aviles-Olmos, I. (Iciar), Balkau, B. (Beverley), Barricarte, A. (Aurelio), Barroso, I.E. (Inês), Garcia, S.B. (Sara Benlloch), Bis, J.C. (Joshua), Blankenberg, S. (Stefan), Boehnke, M. (Michael), Boeing, H. (Heiner), Boerwinkle, E.A. (Eric), Borecki, I.B. (Ingrid), Bork-Jensen, J. (Jette), Bowden, S. (Sarah), Caldas, C. (Carlos), Caslake, M. (Muriel), Cupples, L.A. (Adrienne), Cruchaga, C. (Carlos), Czajkowski, J. (Jacek), Hoed, M. (Marcel) den, Dunn, J.A. (Janet A.), Earl, H. (Helena), Ehret, G.B. (Georg), Ferrannini, E. (Ele), Ferrieres, J. (Jean), Foltynie, T. (Thomas), Ford, I. (Ian), Forouhi, N.G. (Nita), Gianfagna, F. (Francesco), Gonzalez, C. (Carlos), Grioni, S. (Sara), Hiller, L. (Louise), Jansson, J.H., Jørgensen, M.E. (Marit E.), Jukema, J.W. (Jan Wouter), Kaaks, R. (Rudolf), Kee, F. (Frank), Kerrison, N.D. (Nicola D.), Key, T. (Tim), Kontto, J. (Jukka), Kote-Jarai, Z., Kraja, A. (Aldi), Kuulasmaa, K. (Kari), Kuusisto, J. (Johanna), Linneberg, A. (Allan), Liu, C. (Chunyu), Marenne, G. (Gaëlle), Mohlke, K.L. (Karen), Morris, A.P. (Andrew), Muir, K.R. (K.), Müller-Nurasyid, M. (Martina), Munroe, P. (Patricia), Navarro, C. (Carmen), Nielsen, S.F. (Sune), Nilsson, P. (Peter), Nordestgaard, B.G. (Børge), Packard, C.J. (Chris J.), Palli, D. (Domenico), Panico, S. (Salvatore), Peloso, G.M. (Gina), Perola, M. (Markus), Peters, A. (Annette), Poole, C.J. (Christopher J.), Quirós, J.R., Rolandsson, O. (Olov), Sacerdote, C. (Carlotta), Salomaa, V. (Veikko), Sánchez, M.-J. (María-José), Sattar, N. (Naveed), Sharp, S.J. (Stephen), Sims, R. (Rebecca), Slimani, N. (Nadia), Smith, J.A. (Jennifer A), Thompson, D. (Deborah), Trompet, S. (Stella), Tumino, R. (Rosario), Van Der A, D.L. (Daphne L.), Schouw, Y.T. (Yvonne) van der, Virtamo, J. (Jarmo), Walker, M. (Mark), Walter, K. (Klaudia), Abraham, J.E. (Jean E.), Amundadottir, L.T. (Laufey T.), Butterworth, A.S. (Adam), Aponte, J.L. (Jennifer L), Dupuis, J. (Josée), Easton, D.F. (Douglas F.), Eeles, R. (Rosalind), Erdmann, J. (Jeanette), Franks, P.W. (Paul), Frayling, T.M. (Timothy), Hansen, T. (T.), Howson, J.M.M. (Joanna M.M.), Jorgensen, T. (Torben), Kooner, J.S. (Jaspal S.), Laakso, M. (Markku), McCarthy, M.I. (Mark), Pankow, J.S. (James), Pedersen, O. (Oluf), Riboli, E. (Elio), Rotter, J.I. (Jerome I.), Saleheen, D. (Danish), Samani, N.J. (Nilesh), Schunkert, H. (Heribert), Vollenweider, P. (Peter), O'Rahilly, S. (Stephen), Deloukas, P. (Panagiotis), Danesh, J. (John), Goodarzi, M. (Mark), Kathiresan, S. (Sekar), Meigs, J.B. (James), Ehm, M.G. (Margaret G), Wareham, N.J. (Nick), and Waterworth, D. (Dawn)
Abstract: Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11, 806 individuals by targeted exome sequencing and follow-up in 39, 979 individuals by targeted genotyping, with additional in silico follow-up in consortia. We used these data to first compare associations of variants in genes encoding drug targets with the effects of pharmacological manipulation of those targets in clinical trials. We then tested the association of those variants with disease outcomes, including coronary heart disease, to predict cardiovascular safety of these agents. A low-frequency missense variant (Ala316Thr; rs10305492) in the gene encoding glucagon-like peptide-1 receptor (GLP1R), the target of GLP1R agonists, was associated with lower fasting glucose and T2D risk, consistent with GLP1R agonist therapies. The minor allele was also associated with protection against heart disease, thus providing evidence that GLP1R agonists are not likely to be associated with an unacceptable increase in cardiovascular risk. Our results provide an encouraging signal that these agents may be associated with benefit, a question currently being addressed in randomized controlled trials. Genetic variants associated with metabolic traits and multiple disease outcomes can be used to validate therapeutic targets at an early stage in the drug development process.
Published: 2016
Full Text: View/download PDF

23. A century of trends in adult human height

Author: Bentham, J. (James), Di Cesare, M. (Mariachiara), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Bixby, H. (Honor), Cowan, M. (Melanie), Fortunato, L. (Léa), Bennett, J.E. (James E.), Danaei, G. (Goodarz), Hajifathalian, K. (Kaveh), Lu, Y. (Yuan), Riley, L.M. (Leanne M.), Laxmaiah, A. (Avula), Kontis, V. (Vasilis), Paciorek, C.J. (Christopher J.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Al-Hazzaa, H.M. (Hazzaa M.), Al-Othman, A.R. (Amani Rashed), Raddadi, R.A. (Rajaa Al), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala’a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (Hongsheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C. E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-de-Mesquita, H.B. (H. Bas), Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A.W.M. (Angelique), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Deschamps, V. (Valérie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T. P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Peña, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gonçalves, H. (Helen), Gross, M., González Rivas, J.P. (Juan P.), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Gualdi-Russo, E. (Emanuela), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Guo, X. (Xiuhua), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Husseini, A. (Abdullatif), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen M.), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H.C.G., Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Tim), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M. S. L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klimont, J. (Jeannette), Klumbiene, J. (Jurate), Koirala, B. (Bhawesh), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kubinova, R., Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Krishna Kumar, R., Kurjata, P. (Pawel), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L.E. (Lars E.), Bao, K.L.N. (Khanh Le Nguyen), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J.J.M. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M., Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G.L.L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Malyutina, S., Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Yusof, S.M. (Safiah Md), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B. M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Jaime Miranda, J., Mišigoj-Durakovic, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Neal, W.A. (William A.), Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), O’Reilly, D. (Dermot), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M.-M. (Mah-mudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroong-Wasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo Horimoto, A.R.V. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Saramies, J. (Jouko), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shibuya, K. (Kenji), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y. E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sørensen, T.I.A. (Thorkild), Soric, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Shyong Tai, E., Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M.R. (Mohammed Rasoul), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Toselli, S. (Stefania), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Turley, M.L. (Maria L.), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A. M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H.M.T. (Hannu M. T.), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Verstraeten, R. (Roosmarijn), Victora, C.G. (Cesar G.), Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Goya Wannamethee, S., Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C.W. (Frederick C.), Wu, J. (Jianfeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., Cisneros, J.Z. (Julio Zuñiga), Bentham, J. (James), Di Cesare, M. (Mariachiara), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Bixby, H. (Honor), Cowan, M. (Melanie), Fortunato, L. (Léa), Bennett, J.E. (James E.), Danaei, G. (Goodarz), Hajifathalian, K. (Kaveh), Lu, Y. (Yuan), Riley, L.M. (Leanne M.), Laxmaiah, A. (Avula), Kontis, V. (Vasilis), Paciorek, C.J. (Christopher J.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Al-Hazzaa, H.M. (Hazzaa M.), Al-Othman, A.R. (Amani Rashed), Raddadi, R.A. (Rajaa Al), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala’a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (Hongsheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C. E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-de-Mesquita, H.B. (H. Bas), Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A.W.M. (Angelique), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Deschamps, V. (Valérie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T. P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Peña, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gonçalves, H. (Helen), Gross, M., González Rivas, J.P. (Juan P.), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Gualdi-Russo, E. (Emanuela), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Guo, X. (Xiuhua), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Husseini, A. (Abdullatif), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen M.), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H.C.G., Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Tim), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M. S. L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klimont, J. (Jeannette), Klumbiene, J. (Jurate), Koirala, B. (Bhawesh), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kubinova, R., Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Krishna Kumar, R., Kurjata, P. (Pawel), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L.E. (Lars E.), Bao, K.L.N. (Khanh Le Nguyen), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J.J.M. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M., Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G.L.L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Malyutina, S., Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Yusof, S.M. (Safiah Md), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B. M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Jaime Miranda, J., Mišigoj-Durakovic, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Neal, W.A. (William A.), Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), O’Reilly, D. (Dermot), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M.-M. (Mah-mudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroong-Wasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo Horimoto, A.R.V. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Saramies, J. (Jouko), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shibuya, K. (Kenji), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y. E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sørensen, T.I.A. (Thorkild), Soric, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Shyong Tai, E., Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M.R. (Mohammed Rasoul), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Toselli, S. (Stefania), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Turley, M.L. (Maria L.), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A. M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H.M.T. (Hannu M. T.), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Verstraeten, R. (Roosmarijn), Victora, C.G. (Cesar G.), Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Goya Wannamethee, S., Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C.W. (Frederick C.), Wu, J. (Jianfeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., and Cisneros, J.Z. (Julio Zuñiga)
Abstract: Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3- 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8- 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
Published: 2016
Full Text: View/download PDF

24. Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants

Author: Di Cesare, M. (Mariachiara), Bentham, J. (James), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Danaei, G. (Goodarz), Lu, Y. (Yuan), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Riley, L.M. (Leanne M.), Hajifathalian, K. (Kaveh), Fortunato, L. (Léa), Taddei, C. (Cristina), Bennett, J.E. (James E.), Ikeda, N. (Nayu), Khang, Y.-H. (Young-Ho), Kyobutungi, C. (Catherine), Laxmaiah, A. (Avula), Li, Y. (Yanping), Lin, H.-H. (Hsien-Ho), Miranda, J.J. (J. Jaime), Mostafa, A. (Aya), Turley, M.L. (Maria L.), Paciorek, C.J. (Christopher J.), Gunter, M. (Marc), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala'a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Andrade, D.S. (Dolores S.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (HongSheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blake, M. (Margaret), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C.E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-De-Mesquita, H.B., Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chan, A.W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), D'Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-Da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T.P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), De La Peña, J.E. (Jorge Escobedo), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Guo, X.H. (Xiu H.), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hardy, R., Kumar, R.H. (Rachakulla Hari), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Hussieni, A.S. (Abdullatif S.), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Kelishadi, R. (Roya), Kemper, H.H.C.G. (Han H.C.G.), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M.S.L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Kiyohara, Y. (Yutaka), Klimont, J. (Jeannette), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R.K. (R. Krishna), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L.E. (Lars E.), Le Nguyen Bao, K. (Khanh), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Munoz, L.M. (Luz M.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Md Yusof, S. (Safiah), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Mendes, L.L. (Larissa L.), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B.M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Mišigoj-Duraković, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), De Wit, T.F.R. (Tobias Floris Rinke), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroongwasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y.E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Sorić, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Tai, E.S. (E. Shyong), Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. (Mohammed), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T.H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, J. (JianFeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., Cisneros, J.Z. (Julio Zuñiga), Di Cesare, M. (Mariachiara), Bentham, J. (James), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Danaei, G. (Goodarz), Lu, Y. (Yuan), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Riley, L.M. (Leanne M.), Hajifathalian, K. (Kaveh), Fortunato, L. (Léa), Taddei, C. (Cristina), Bennett, J.E. (James E.), Ikeda, N. (Nayu), Khang, Y.-H. (Young-Ho), Kyobutungi, C. (Catherine), Laxmaiah, A. (Avula), Li, Y. (Yanping), Lin, H.-H. (Hsien-Ho), Miranda, J.J. (J. Jaime), Mostafa, A. (Aya), Turley, M.L. (Maria L.), Paciorek, C.J. (Christopher J.), Gunter, M. (Marc), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala'a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Andrade, D.S. (Dolores S.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (HongSheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blake, M. (Margaret), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C.E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-De-Mesquita, H.B., Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chan, A.W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), D'Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-Da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T.P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), De La Peña, J.E. (Jorge Escobedo), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Guo, X.H. (Xiu H.), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hardy, R., Kumar, R.H. (Rachakulla Hari), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Hussieni, A.S. (Abdullatif S.), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Kelishadi, R. (Roya), Kemper, H.H.C.G. (Han H.C.G.), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M.S.L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Kiyohara, Y. (Yutaka), Klimont, J. (Jeannette), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R.K. (R. Krishna), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L.E. (Lars E.), Le Nguyen Bao, K. (Khanh), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Munoz, L.M. (Luz M.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Md Yusof, S. (Safiah), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Mendes, L.L. (Larissa L.), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B.M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Mišigoj-Duraković, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), De Wit, T.F.R. (Tobias Floris Rinke), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroongwasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y.E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Sorić, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Tai, E.S. (E. Shyong), Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. (Mohammed), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T.H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, J. (JianFeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., and Cisneros, J.Z. (Julio Zuñiga)
Abstract: Copyright
Published: 2016
Full Text: View/download PDF

25. A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

Author: Travis, S.P.L. (Simon), Appleby, P.N. (Paul N.), Martin, R.M. (Richard M.), Holly, J.M.P. (Jeff), Albanes, D. (Demetrius), Black, A., Bueno-De-Mesquita, H.B. (H. Bas), Chan, J.M. (June M.), Chen, C. (Chu), Chirlaque, M.D. (M.), Cook, M.B. (Michael B.), Deschasaux, M. (Mélanie), Donovan, J. (Jenny), Ferrucci, L. (Luigi), Galan, P. (Pilar), Giles, G.G. (Graham), Giovannucci, E.L. (Edward L.), Gunter, M.J. (Marc J.), Habel, L.A. (Laurel A.), Hamdy, F. (Freddie), Helzlsouer, K.J. (Kathy J.), Hercberg, S. (Serge), Hoover, R.N. (Robert), Janssen, J.A.M.J.L. (Joop), Kaaks, R. (Rudolf), Kubo, T. (Tatsuhiko), Le Marchand, L. (Loic), Metter, E.J. (E. Jeffrey), Mikami, K. (Kazuya), Morris, J.K. (Joan K.), Neal, D.E. (David E.), Neuhouser, M.L. (Marian L.), Ozasa, K. (Kotaro), Palli, D. (Domenico), Platz, E.A. (Elizabeth A.), Pollak, M.N. (Michael), Price, A.J. (Alison J.), Roobol-Bouts, M.J. (Monique), Schaefer, C. (Catherine), Schenk, J.M. (Jeannette M.), Severi, G. (Gianluca), Stampfer, M.J. (Meir J.), Stattin, P. (Pär), Tamakoshi, A. (Akiko), Tangen, C.M. (Catherine M.), Touvier, M. (Mathilde), Wald, A. (Anna), Weiss, N.S. (Noel S.), Ziegler, R.G. (Regina), Key, T. (Tim), Allen, N.E. (Naomi), Travis, S.P.L. (Simon), Appleby, P.N. (Paul N.), Martin, R.M. (Richard M.), Holly, J.M.P. (Jeff), Albanes, D. (Demetrius), Black, A., Bueno-De-Mesquita, H.B. (H. Bas), Chan, J.M. (June M.), Chen, C. (Chu), Chirlaque, M.D. (M.), Cook, M.B. (Michael B.), Deschasaux, M. (Mélanie), Donovan, J. (Jenny), Ferrucci, L. (Luigi), Galan, P. (Pilar), Giles, G.G. (Graham), Giovannucci, E.L. (Edward L.), Gunter, M.J. (Marc J.), Habel, L.A. (Laurel A.), Hamdy, F. (Freddie), Helzlsouer, K.J. (Kathy J.), Hercberg, S. (Serge), Hoover, R.N. (Robert), Janssen, J.A.M.J.L. (Joop), Kaaks, R. (Rudolf), Kubo, T. (Tatsuhiko), Le Marchand, L. (Loic), Metter, E.J. (E. Jeffrey), Mikami, K. (Kazuya), Morris, J.K. (Joan K.), Neal, D.E. (David E.), Neuhouser, M.L. (Marian L.), Ozasa, K. (Kotaro), Palli, D. (Domenico), Platz, E.A. (Elizabeth A.), Pollak, M.N. (Michael), Price, A.J. (Alison J.), Roobol-Bouts, M.J. (Monique), Schaefer, C. (Catherine), Schenk, J.M. (Jeannette M.), Severi, G. (Gianluca), Stampfer, M.J. (Meir J.), Stattin, P. (Pär), Tamakoshi, A. (Akiko), Tangen, C.M. (Catherine M.), Touvier, M. (Mathilde), Wald, A. (Anna), Weiss, N.S. (Noel S.), Ziegler, R.G. (Regina), Key, T. (Tim), and Allen, N.E. (Naomi)
Abstract: The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the hi
Published: 2016
Full Text: View/download PDF

26. Identification of novel genetic markers of breast cancer survival

Author: Guo, Q. (Qi), Schmidt, M.K. (Marjanka), Kraft, P. (Peter), Canisius, S. (Sander), Chen, C. (Constance), Khan, S. (Sofia), Tyrer, J.P. (Jonathan), Bolla, M.K. (Manjeet), Wang, Q. (Qing), Dennis, J. (Joe), Michailidou, K. (Kyriaki), Lush, M. (Michael), Kar, S. (Siddhartha), Beesley, J. (Jonathan), Dunning, A.M. (Alison), Shah, M. (Mitul), Czene, K. (Kamila), Darabi, H. (Hatef), Eriksson, M. (Mikael), Lambrechts, D. (Diether), Weltens, C. (Caroline), Leunen, K., Bojesen, S.E. (Stig), Nordestgaard, B.G. (Børge), Nielsen, S.F. (Sune), Flyger, H. (Henrik), Chang-Claude, J. (Jenny), Rudolph, A. (Anja), Seibold, P. (Petra), Flesch-Janys, D. (Dieter), Blomqvist, C. (Carl), Aittomäki, K. (Kristiina), Fagerholm, R. (Rainer), Muranen, T.A. (Taru), Couch, F.J. (Fergus), Olson, J.E. (Janet), Vachon, C. (Celine), Andrulis, I.L. (Irene), Knight, J.A. (Julia), Glendon, G. (Gord), Mulligan, A.-M. (Anna-Marie), Broeks, A. (Annegien), Hogervorst, F.B.L. (Frans), Haiman, C.A. (Christopher), Henderson, B.E. (Brian), Schumacher, F.R. (Fredrick), Le Marchand, L. (Loic), Hopper, J. (John), Tsimiklis, H. (Helen), Apicella, C. (Carmel), Southey, M.C. (Melissa), Cox, A. (Angela), Cross, S.S. (Simon), Reed, M.W.R. (Malcolm), Giles, G.G. (Graham G.), Milne, R.L. (Roger L.), McLean, C.A. (Catriona Ann), Winqvist, R. (Robert), Pykäs, K. (Katri), Jukkola-Vuorinen, A. (Arja), Grip, M. (Mervi), Hooning, M.J. (Maartje), Hollestelle, A. (Antoinette), Martens, J.W.M. (John W. M.), Ouweland, A.M.W. (Ans) van den, Marme, F. (Federick), Schneeweiss, A. (Andreas), Yang, R. (Rongxi), Burwinkel, B. (Barbara), Figueroa, J.D. (Jonine), Chanock, S.J. (Stephen), Lissowska, J. (Jolanta), Sawyer, E.J. (Elinor), Tomlinson, I.P. (Ian), Kerin, M. (Michael), Miller, N. (Nicola), Brenner, H. (Hermann), Dieffenbach, A.K. (Aida Karina), Arndt, V. (Volker), Holleczek, B. (B.), Mannermaa, A. (Arto), Kataja, V. (Vesa), Kosma, V-M. (Veli-Matti), Hartikainen, J.M. (J.), Li, J. (Jingmei), Brand, J.S. (Judith S.), Humphreys, M.K. (Manjeet), Devilee, P. (Peter), Tollenaar, R.A.E.M. (Rob), Seynaeve, C.M. (Caroline), Radice, P. (Paolo), Peterlongo, P. (Paolo), Bonnani, B. (Bernardo), Mariani, P. (Paolo), Fasching, P.A. (Peter), Beckmann, M.W. (Matthias), Hein, R. (Rebecca), Ekici, A.B. (Arif), Chenevix-Trench, G. (Georgia), Balleine, R. (Rosemary), Phillips, K.-A. (Kelly-Anne), Benítez, J. (Javier), Zamora, M.P. (Pilar), Arias Pérez, J.I. (José Ignacio), Menéndez, P. (Primitiva), Jakubowska, A. (Anna), Lubinski, J. (Jan), Jaworska-Bieniek, K. (Katarzyna), Durda, K. (Katarzyna), Hamann, U. (Ute), Kabisch, M. (Maria), Ulmer, H.U. (Hans), Rud̈iger, T. (Thomas), Margolin, S. (Sara), Kristensen, V. (Vessela), Nord, S. (Silje), Evans, D.G. (Gareth), Abraham, J. (Jean), Earl, H. (Helena), Hiller, L. (Louise), Dunn, J.A. (J.), Bowden, S. (Sarah), Berg, C.D. (Christine), Campa, D. (Daniele), Diver, W.R. (Ryan), Gapstur, S.M. (Susan M.), Gaudet, M.M. (Mia), Hankinson, S.E. (Susan), Hoover, R.N. (Robert), Hüsing, A. (Anika), Kaaks, R. (Rudolf), Machiela, M.J. (Mitchell J.), Willett, W.C. (Walter C.), Barrdahl, M. (Myrto), Canzian, F. (Federico), Chin, S.-F. (Suet-Feung), Caldas, C. (Carlos), Hunter, D. (David), Lindstrom, S. (Stephen), García-Closas, M. (Montserrat), Hall, P. (Per), Easton, D.F. (Douglas), Eccles, D. (Diana), Rahman, N. (Nazneen), Nevanlinna, H. (Heli), Pharoah, P.D.P. (Paul), Guo, Q. (Qi), Schmidt, M.K. (Marjanka), Kraft, P. (Peter), Canisius, S. (Sander), Chen, C. (Constance), Khan, S. (Sofia), Tyrer, J.P. (Jonathan), Bolla, M.K. (Manjeet), Wang, Q. (Qing), Dennis, J. (Joe), Michailidou, K. (Kyriaki), Lush, M. (Michael), Kar, S. (Siddhartha), Beesley, J. (Jonathan), Dunning, A.M. (Alison), Shah, M. (Mitul), Czene, K. (Kamila), Darabi, H. (Hatef), Eriksson, M. (Mikael), Lambrechts, D. (Diether), Weltens, C. (Caroline), Leunen, K., Bojesen, S.E. (Stig), Nordestgaard, B.G. (Børge), Nielsen, S.F. (Sune), Flyger, H. (Henrik), Chang-Claude, J. (Jenny), Rudolph, A. (Anja), Seibold, P. (Petra), Flesch-Janys, D. (Dieter), Blomqvist, C. (Carl), Aittomäki, K. (Kristiina), Fagerholm, R. (Rainer), Muranen, T.A. (Taru), Couch, F.J. (Fergus), Olson, J.E. (Janet), Vachon, C. (Celine), Andrulis, I.L. (Irene), Knight, J.A. (Julia), Glendon, G. (Gord), Mulligan, A.-M. (Anna-Marie), Broeks, A. (Annegien), Hogervorst, F.B.L. (Frans), Haiman, C.A. (Christopher), Henderson, B.E. (Brian), Schumacher, F.R. (Fredrick), Le Marchand, L. (Loic), Hopper, J. (John), Tsimiklis, H. (Helen), Apicella, C. (Carmel), Southey, M.C. (Melissa), Cox, A. (Angela), Cross, S.S. (Simon), Reed, M.W.R. (Malcolm), Giles, G.G. (Graham G.), Milne, R.L. (Roger L.), McLean, C.A. (Catriona Ann), Winqvist, R. (Robert), Pykäs, K. (Katri), Jukkola-Vuorinen, A. (Arja), Grip, M. (Mervi), Hooning, M.J. (Maartje), Hollestelle, A. (Antoinette), Martens, J.W.M. (John W. M.), Ouweland, A.M.W. (Ans) van den, Marme, F. (Federick), Schneeweiss, A. (Andreas), Yang, R. (Rongxi), Burwinkel, B. (Barbara), Figueroa, J.D. (Jonine), Chanock, S.J. (Stephen), Lissowska, J. (Jolanta), Sawyer, E.J. (Elinor), Tomlinson, I.P. (Ian), Kerin, M. (Michael), Miller, N. (Nicola), Brenner, H. (Hermann), Dieffenbach, A.K. (Aida Karina), Arndt, V. (Volker), Holleczek, B. (B.), Mannermaa, A. (Arto), Kataja, V. (Vesa), Kosma, V-M. (Veli-Matti), Hartikainen, J.M. (J.), Li, J. (Jingmei), Brand, J.S. (Judith S.), Humphreys, M.K. (Manjeet), Devilee, P. (Peter), Tollenaar, R.A.E.M. (Rob), Seynaeve, C.M. (Caroline), Radice, P. (Paolo), Peterlongo, P. (Paolo), Bonnani, B. (Bernardo), Mariani, P. (Paolo), Fasching, P.A. (Peter), Beckmann, M.W. (Matthias), Hein, R. (Rebecca), Ekici, A.B. (Arif), Chenevix-Trench, G. (Georgia), Balleine, R. (Rosemary), Phillips, K.-A. (Kelly-Anne), Benítez, J. (Javier), Zamora, M.P. (Pilar), Arias Pérez, J.I. (José Ignacio), Menéndez, P. (Primitiva), Jakubowska, A. (Anna), Lubinski, J. (Jan), Jaworska-Bieniek, K. (Katarzyna), Durda, K. (Katarzyna), Hamann, U. (Ute), Kabisch, M. (Maria), Ulmer, H.U. (Hans), Rud̈iger, T. (Thomas), Margolin, S. (Sara), Kristensen, V. (Vessela), Nord, S. (Silje), Evans, D.G. (Gareth), Abraham, J. (Jean), Earl, H. (Helena), Hiller, L. (Louise), Dunn, J.A. (J.), Bowden, S. (Sarah), Berg, C.D. (Christine), Campa, D. (Daniele), Diver, W.R. (Ryan), Gapstur, S.M. (Susan M.), Gaudet, M.M. (Mia), Hankinson, S.E. (Susan), Hoover, R.N. (Robert), Hüsing, A. (Anika), Kaaks, R. (Rudolf), Machiela, M.J. (Mitchell J.), Willett, W.C. (Walter C.), Barrdahl, M. (Myrto), Canzian, F. (Federico), Chin, S.-F. (Suet-Feung), Caldas, C. (Carlos), Hunter, D. (David), Lindstrom, S. (Stephen), García-Closas, M. (Montserrat), Hall, P. (Per), Easton, D.F. (Douglas), Eccles, D. (Diana), Rahman, N. (Nazneen), Nevanlinna, H. (Heli), and Pharoah, P.D.P. (Paul)
Abstract: Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with breast cancer-specific survival. Methods: We conducted a large meta-analysis of studies in populations of European ancestry, including 37954 patients with 2900 deaths from breast cancer. Each study had been genotyped for between 200000 and 900000 single nucleotide polymorphisms (SNPs) across the genome; genotypes for nine million common variants were imputed using a common reference panel from the 1000 Genomes Project. We also carried out subtype-specific analyses based on 6881 estrogen receptor (ER)-negative patients (920 events) and 23059 ER-positive patients (1333 events). All statistical tests were two-sided. Results: We identified one new locus (rs2059614 at 11q24.2) associated with survival in ER-negative breast cancer cases (hazard ratio [HR] = 1.95, 95% confidence interval [CI] = 1.55 to 2.47, P = 1.91 x 10-8). Genotyping a subset of 2113 case patients, of which 300 were ER negative, provided supporting evidence for the quality of the imputation. The association in this set of case patients was stronger for the observed genotypes than for the imputed genotypes. A second locus (rs148760487 at 2q24.2) was associated at genome-wide statistical significance in initial analyses; the association was similar in ER-positive and ER-negative case patients. Here the results of genotyping suggested that the finding was less robust. Conclusions: This is currently the largest study investigating genetic variation associated with breast cancer survival. Our results have potential clinical implications, as they confirm that germline genotype can provide prognostic information in addition to standard tumor prognostic factors.
Published: 2015
Full Text: View/download PDF

27. Common germline polymorphisms associated with breast cancer-specific survival

Author: Pirie, A. (Ailith), Guo, Q. (Qi), Kraft, P. (Peter), Canisius, S. (Sander), Eccles, D. (Diana), Rahman, N. (Nazneen), Nevanlinna, H. (Heli), Chen, C. (Constance), Khan, S. (Sofia), Tyrer, J.P. (Jonathan), Bolla, M.K. (Manjeet), Wang, Q. (Qing), Dennis, J. (Joe), Michailidou, K. (Kyriaki), Lush, M. (Michael), Dunning, A.M. (Alison), Shah, M. (Mitul), Czene, K. (Kamila), Darabi, H. (Hatef), Eriksson, M. (Mats), Lambrechts, D. (Diether), Weltens, C. (Caroline), Leunen, K., van Ongeval, C. (Chantal), Nordestgaard, B.G. (Børge), Nielsen, S.F. (Sune), Flyger, H. (Henrik), Rudolph, A. (Anja), Seibold, P. (Petra), Flesch-Janys, D. (Dieter), Blomqvist, C. (Carl), Aittomäki, K. (Kristiina), Fagerholm, R. (Rainer), Muranen, T.A. (Taru), Olsen, J.E. (Janet E.), Hallberg, B. (Boubou), Vachon, C. (Celine), Knight, J.A. (Julia), Glendon, G. (Gord), Mulligan, A.M. (Anna Marie), Broeks, A. (Annegien), Cornelissen, S. (Sten), Haiman, C.A. (Christopher), Henderson, B.E. (Brian), Schumacher, F. (Frederick), Le Marchand, L. (Loic), Hopper, J.L. (John), Tsimiklis, H. (Helen), Apicella, C. (Carmel), Southey, M.C. (Melissa), Cross, S.S. (Simon), Reed, M.W.R. (Malcolm), Giles, G.G. (Graham), Milne, R.L. (Roger), McLean, C.A. (Catriona Ann), Winqvist, R. (Robert), Pykäs, K. (Katri), Jukkola-Vuorinen, A. (Arja), Grip, M. (Mervi), Hooning, M.J. (Maartje), Hollestelle, A. (Antoinette), Martens, J.W.M. (John), Ouweland, A.M.W. (Ans) van den, Marme, F. (Federick), Schneeweiss, A. (Andreas), Yang, R. (Rongxi), Burwinkel, B. (Barbara), Figueroa, J.D. (Jonine), Chanock, S.J. (Stephen), Lissowska, J. (Jolanta), Sawyer, E.J. (Elinor), Tomlinson, I.P. (Ian), Kerin, M. (Michael), Miller, N. (Nicola), Brenner, H. (Hermann), Butterbach, K. (Katja), Holleczek, B. (B.), Kataja, V. (Vesa), Kosma, V-M. (Veli-Matti), Hartikainen, J.M. (J.), Li, J. (Jingmei), Brand, J.S. (Judith S.), Humphreys, M.K. (Manjeet), Devilee, P. (Peter), Tollenaar, R.A.E.M. (Rob), Seynaeve, C.M. (Caroline), Radice, P. (Paolo), Peterlongo, P. (Paolo), Manoukian, S. (Siranoush), Ficarazzi, F. (Filomena), Beckmann, M.W. (Matthias), Hein, R. (Rebecca), Ekici, A.B. (Arif), Balleine, R. (Rosemary), Phillips, K.-A. (Kelly-Anne), Benítez, J. (Javier), Zamora, M.P. (Pilar), Perez, J.I.A. (Jose Ignacio Arias), Menéndez, P. (Primitiva), Jakubowska, A. (Anna), Lubinski, J. (Jan), Gronwald, J. (Jacek), Durda, K. (Katarzyna), Hamann, U. (Ute), Kabisch, M. (Maria), Ulmer, H.U. (Hans), Rud̈iger, T. (Thomas), Margolin, S. (Sara), Kristensen, V. (Vessela), Nord, S. (Siljie), Evans, D.G. (Gareth), Abraham, J. (Jean), Earl, H. (Helena), Poole, C.J. (Christopher J.), Hiller, L. (Louise), Dunn, J.A. (J.), Bowden, S. (Sarah), Yang, R. (Rose), Campa, D. (Daniele), Diver, W.R. (Ryan), Gapstur, S.M. (Susan M.), Gaudet, M.M. (Mia), Hankinson, S.E. (Susan), Hoover, R.N. (Robert), Hüsing, A. (Anika), Kaaks, R. (Rudolf), Machiela, M.J. (Mitchell J.), Willett, W.C. (Walter C.), Barrdahl, M. (Myrto), Canzian, F. (Federico), Chin, S.-F. (Suet-Feung), Caldas, C. (Carlos), Hunter, D. (David), Lindstrom, S. (Stephen), García-Closas, M. (Montserrat), Couch, F.J. (Fergus), Chenevix-Trench, G. (Georgia), Mannermaa, A. (Arto), Andrulis, I.L. (Irene), Hall, P. (Per), Chang-Claude, J. (Jenny), Easton, D.F. (Douglas), Bojesen, S.E. (Stig), Cox, A. (Angela), Fasching, P.A. (Peter), Pharoah, P.D.P. (Paul), Schmidt, M.K. (Marjanka), Pirie, A. (Ailith), Guo, Q. (Qi), Kraft, P. (Peter), Canisius, S. (Sander), Eccles, D. (Diana), Rahman, N. (Nazneen), Nevanlinna, H. (Heli), Chen, C. (Constance), Khan, S. (Sofia), Tyrer, J.P. (Jonathan), Bolla, M.K. (Manjeet), Wang, Q. (Qing), Dennis, J. (Joe), Michailidou, K. (Kyriaki), Lush, M. (Michael), Dunning, A.M. (Alison), Shah, M. (Mitul), Czene, K. (Kamila), Darabi, H. (Hatef), Eriksson, M. (Mats), Lambrechts, D. (Diether), Weltens, C. (Caroline), Leunen, K., van Ongeval, C. (Chantal), Nordestgaard, B.G. (Børge), Nielsen, S.F. (Sune), Flyger, H. (Henrik), Rudolph, A. (Anja), Seibold, P. (Petra), Flesch-Janys, D. (Dieter), Blomqvist, C. (Carl), Aittomäki, K. (Kristiina), Fagerholm, R. (Rainer), Muranen, T.A. (Taru), Olsen, J.E. (Janet E.), Hallberg, B. (Boubou), Vachon, C. (Celine), Knight, J.A. (Julia), Glendon, G. (Gord), Mulligan, A.M. (Anna Marie), Broeks, A. (Annegien), Cornelissen, S. (Sten), Haiman, C.A. (Christopher), Henderson, B.E. (Brian), Schumacher, F. (Frederick), Le Marchand, L. (Loic), Hopper, J.L. (John), Tsimiklis, H. (Helen), Apicella, C. (Carmel), Southey, M.C. (Melissa), Cross, S.S. (Simon), Reed, M.W.R. (Malcolm), Giles, G.G. (Graham), Milne, R.L. (Roger), McLean, C.A. (Catriona Ann), Winqvist, R. (Robert), Pykäs, K. (Katri), Jukkola-Vuorinen, A. (Arja), Grip, M. (Mervi), Hooning, M.J. (Maartje), Hollestelle, A. (Antoinette), Martens, J.W.M. (John), Ouweland, A.M.W. (Ans) van den, Marme, F. (Federick), Schneeweiss, A. (Andreas), Yang, R. (Rongxi), Burwinkel, B. (Barbara), Figueroa, J.D. (Jonine), Chanock, S.J. (Stephen), Lissowska, J. (Jolanta), Sawyer, E.J. (Elinor), Tomlinson, I.P. (Ian), Kerin, M. (Michael), Miller, N. (Nicola), Brenner, H. (Hermann), Butterbach, K. (Katja), Holleczek, B. (B.), Kataja, V. (Vesa), Kosma, V-M. (Veli-Matti), Hartikainen, J.M. (J.), Li, J. (Jingmei), Brand, J.S. (Judith S.), Humphreys, M.K. (Manjeet), Devilee, P. (Peter), Tollenaar, R.A.E.M. (Rob), Seynaeve, C.M. (Caroline), Radice, P. (Paolo), Peterlongo, P. (Paolo), Manoukian, S. (Siranoush), Ficarazzi, F. (Filomena), Beckmann, M.W. (Matthias), Hein, R. (Rebecca), Ekici, A.B. (Arif), Balleine, R. (Rosemary), Phillips, K.-A. (Kelly-Anne), Benítez, J. (Javier), Zamora, M.P. (Pilar), Perez, J.I.A. (Jose Ignacio Arias), Menéndez, P. (Primitiva), Jakubowska, A. (Anna), Lubinski, J. (Jan), Gronwald, J. (Jacek), Durda, K. (Katarzyna), Hamann, U. (Ute), Kabisch, M. (Maria), Ulmer, H.U. (Hans), Rud̈iger, T. (Thomas), Margolin, S. (Sara), Kristensen, V. (Vessela), Nord, S. (Siljie), Evans, D.G. (Gareth), Abraham, J. (Jean), Earl, H. (Helena), Poole, C.J. (Christopher J.), Hiller, L. (Louise), Dunn, J.A. (J.), Bowden, S. (Sarah), Yang, R. (Rose), Campa, D. (Daniele), Diver, W.R. (Ryan), Gapstur, S.M. (Susan M.), Gaudet, M.M. (Mia), Hankinson, S.E. (Susan), Hoover, R.N. (Robert), Hüsing, A. (Anika), Kaaks, R. (Rudolf), Machiela, M.J. (Mitchell J.), Willett, W.C. (Walter C.), Barrdahl, M. (Myrto), Canzian, F. (Federico), Chin, S.-F. (Suet-Feung), Caldas, C. (Carlos), Hunter, D. (David), Lindstrom, S. (Stephen), García-Closas, M. (Montserrat), Couch, F.J. (Fergus), Chenevix-Trench, G. (Georgia), Mannermaa, A. (Arto), Andrulis, I.L. (Irene), Hall, P. (Per), Chang-Claude, J. (Jenny), Easton, D.F. (Douglas), Bojesen, S.E. (Stig), Cox, A. (Angela), Fasching, P.A. (Peter), Pharoah, P.D.P. (Paul), and Schmidt, M.K. (Marjanka)
Abstract: Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect. Results: Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease. Conclusions: Although no variants reached genome-wide significance (P <5 x 10-8), these results suggest that there is some evidence of association between candidate common germline variants an
Published: 2015
Full Text: View/download PDF

28. Rare coding variants and X-linked loci associated with age at menarche

Author: Lunetta, K.L. (Kathryn), Day, F.R. (Felix), Sulem, P. (Patrick), Ruth, K.S. (Katherine S.), Tung, J.Y. (Joyce Y.), Hinds, D.A. (David A.), Esko, T. (Tõnu), Elks, C.E. (Cathy), Altmaier, E.L. (Elizabeth), He, C. (Chunyan), Huffman, J.E. (Jennifer), Mihailov, E. (Evelin), Porcu, E. (Eleonora), Robino, A. (Antonietta), Rose, L.M. (Lynda), Schick, U.M. (Ursula), Stolk, L. (Lisette), Teumer, A. (Alexander), Thompson, D. (Deborah), Traglia, M. (Michela), Wang, C.A. (Carol A.), Yerges-Armstrong, L.M. (Laura), Antoniou, A.C. (Antonis), Barbieri, C. (Caterina), Coviello, A.D. (Andrea), Cucca, F. (Francesco), Demerath, E.W. (Ellen), Dunning, A.M. (Alison), Gandin, I. (Ilaria), Grove, M.L. (Megan L.), Gudbjartsson, D.F. (Daniel), Hocking, L.J. (Lynne), Hofman, A. (Albert), Huang, J. (Jian), Jackson, R.D. (Rebecca), Karasik, D. (David), Kriebel, J. (Jennifer), Lange, E.M. (Ethan), Lange, L.A. (Leslie), Langenberg, C. (Claudia), Li, X. (Xin), Luan, J., Mägi, R. (Reedik), Morrison, A.C. (Alanna), Padmanabhan, S. (Sandosh), Pirie, A. (Ailith), Polasek, O. (Ozren), Porteous, D.J. (David J.), Reiner, A. (Alexander), Rivadeneira Ramirez, F. (Fernando), Rudan, I. (Igor), Sala, C. (Cinzia), Schlessinger, D. (David), Scott, R.A. (Robert), Stöckl, D. (Doris), Visser, J.A. (Jenny), Völker, U. (Uwe), Vozzi, D. (Diego), Wilson, J.G. (James), Zygmunt, M. (Marek), Boerwinkle, E.A. (Eric), Buring, J.E. (Julie), Crisponi, L. (Laura), Easton, D.F. (Douglas), Hayward, C. (Caroline), Hu, F.B. (Frank), Liu, S. (Simin), Metspalu, A. (Andres), Pennell, C.E. (Craig), Ridker, P.M. (Paul), Strauch, K. (Konstantin), Streeten, E.A. (Elizabeth), Toniolo, D. (Daniela), Uitterlinden, A.G. (André), Ulivi, S. (Shelia), Völzke, H. (Henry), Wareham, N.J. (Nick), Wellons, M. (Melissa), Franceschini, N. (Nora), Chasman, D.I. (Daniel), Thorsteinsdottir, U. (Unnur), Murray, A. (Anna), Zwart, J-A. (John-Anker), Murabito, J. (Joanne), Ong, K.K. (Ken), Perry, J.R.B. (John), Forouhi, N.G. (Nita G.), Kerrison, N.D. (Nicola D.), Sharp, S.J. (Stephen J.), Sims, M.A. (Matthew), Barroso, I.E. (Inês), Deloukas, P. (Panagiotis), McCarthy, M.I. (Mark), Arriola, L. (Larraitz), Balkau, B. (Beverley), Barricarte, A. (Aurelio), Boeing, H. (Heiner), Franks, P.W., Gonzalez, C. (Carlos), Grioni, S. (Sara), Kaaks, R. (Rudolf), Key, T.J. (Timothy J.), Navarro, C. (Carmen), Nilsson, P.M. (Peter M.), Overvad, K. (Kim), Palli, D. (Domenico), Panico, S. (Salvatore), Quirós, J.R., Rolandsson, O. (Olov), Sacerdote, C. (Carlotta), Sánchez, M.-J. (María-José), Slimani, N. (Nadia), Tjonneland, A. (Anne), Tumino, R. (Rosario), Van Der A, D.L. (Daphne L.), Schouw, Y.T. (Yvonne) van der, Riboli, E. (Elio), Smith, B.H. (Blair), Campbell, A. (Archie), Deary, I.J. (Ian), McIntosh, A.M. (Andrew), Lunetta, K.L. (Kathryn), Day, F.R. (Felix), Sulem, P. (Patrick), Ruth, K.S. (Katherine S.), Tung, J.Y. (Joyce Y.), Hinds, D.A. (David A.), Esko, T. (Tõnu), Elks, C.E. (Cathy), Altmaier, E.L. (Elizabeth), He, C. (Chunyan), Huffman, J.E. (Jennifer), Mihailov, E. (Evelin), Porcu, E. (Eleonora), Robino, A. (Antonietta), Rose, L.M. (Lynda), Schick, U.M. (Ursula), Stolk, L. (Lisette), Teumer, A. (Alexander), Thompson, D. (Deborah), Traglia, M. (Michela), Wang, C.A. (Carol A.), Yerges-Armstrong, L.M. (Laura), Antoniou, A.C. (Antonis), Barbieri, C. (Caterina), Coviello, A.D. (Andrea), Cucca, F. (Francesco), Demerath, E.W. (Ellen), Dunning, A.M. (Alison), Gandin, I. (Ilaria), Grove, M.L. (Megan L.), Gudbjartsson, D.F. (Daniel), Hocking, L.J. (Lynne), Hofman, A. (Albert), Huang, J. (Jian), Jackson, R.D. (Rebecca), Karasik, D. (David), Kriebel, J. (Jennifer), Lange, E.M. (Ethan), Lange, L.A. (Leslie), Langenberg, C. (Claudia), Li, X. (Xin), Luan, J., Mägi, R. (Reedik), Morrison, A.C. (Alanna), Padmanabhan, S. (Sandosh), Pirie, A. (Ailith), Polasek, O. (Ozren), Porteous, D.J. (David J.), Reiner, A. (Alexander), Rivadeneira Ramirez, F. (Fernando), Rudan, I. (Igor), Sala, C. (Cinzia), Schlessinger, D. (David), Scott, R.A. (Robert), Stöckl, D. (Doris), Visser, J.A. (Jenny), Völker, U. (Uwe), Vozzi, D. (Diego), Wilson, J.G. (James), Zygmunt, M. (Marek), Boerwinkle, E.A. (Eric), Buring, J.E. (Julie), Crisponi, L. (Laura), Easton, D.F. (Douglas), Hayward, C. (Caroline), Hu, F.B. (Frank), Liu, S. (Simin), Metspalu, A. (Andres), Pennell, C.E. (Craig), Ridker, P.M. (Paul), Strauch, K. (Konstantin), Streeten, E.A. (Elizabeth), Toniolo, D. (Daniela), Uitterlinden, A.G. (André), Ulivi, S. (Shelia), Völzke, H. (Henry), Wareham, N.J. (Nick), Wellons, M. (Melissa), Franceschini, N. (Nora), Chasman, D.I. (Daniel), Thorsteinsdottir, U. (Unnur), Murray, A. (Anna), Zwart, J-A. (John-Anker), Murabito, J. (Joanne), Ong, K.K. (Ken), Perry, J.R.B. (John), Forouhi, N.G. (Nita G.), Kerrison, N.D. (Nicola D.), Sharp, S.J. (Stephen J.), Sims, M.A. (Matthew), Barroso, I.E. (Inês), Deloukas, P. (Panagiotis), McCarthy, M.I. (Mark), Arriola, L. (Larraitz), Balkau, B. (Beverley), Barricarte, A. (Aurelio), Boeing, H. (Heiner), Franks, P.W., Gonzalez, C. (Carlos), Grioni, S. (Sara), Kaaks, R. (Rudolf), Key, T.J. (Timothy J.), Navarro, C. (Carmen), Nilsson, P.M. (Peter M.), Overvad, K. (Kim), Palli, D. (Domenico), Panico, S. (Salvatore), Quirós, J.R., Rolandsson, O. (Olov), Sacerdote, C. (Carlotta), Sánchez, M.-J. (María-José), Slimani, N. (Nadia), Tjonneland, A. (Anne), Tumino, R. (Rosario), Van Der A, D.L. (Daphne L.), Schouw, Y.T. (Yvonne) van der, Riboli, E. (Elio), Smith, B.H. (Blair), Campbell, A. (Archie), Deary, I.J. (Ian), and McIntosh, A.M. (Andrew)
Abstract: More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼ 3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated with age at menarche (minor allele frequencies 0.08-4.6%; effect sizes 0.08-1.25 years per allele; P<5 × 10-8). In addition, we identify common X-chromosome loci at IGSF1 (rs762080, P=9.4 × 10-13) and FAAH2 (rs5914101, P=4.9 × 10-10). Highlighted genes implicate cellular energy homeostasis, post-transcriptional gene silencing and fatty-acid amide signalling. A frequently reported mutation in TACR3 for idiopathic hypogonatrophic hypogonadism (p.W275X) is associated with 1.25-year-later menarche (P=2.8 × 10-11), illustrating the utility of population studies to estimate the penetrance of reportedly pathogenic mutations. Collectively, these novel variants explain ∼0.5% variance, indicating that these overlooked sources of variation do not substantially explain the 'missing heritability' of this complex trait.
Published: 2015
Full Text: View/download PDF

29. Social inequalities and mortality in europe - results from a large multi-national cohort

Author: Gallo, V. (Valentina), Mackenbach, J.P. (Johan), Ezzati, M. (Majid), Menvielle, G. (Gwenn), Kunst, A.E. (Anton), Rohrmann, S. (Sabine), Kaaks, R. (Rudolf), Teucher, B. (Birgit), Boeing, H. (Heiner), Bergmann, M.M. (Manuela), Tjønneland, A. (Anne), Dalton, S.O. (Susanne), Overvad, K. (Kim), Redondo, M.-L. (Maria-Luisa), Agudo, A. (Antonio), Daponte, A. (Antonio), Arriola, L. (Larraitz), Navarro, C. (Carmen), Barricante Gurrea, A. (Aurelio), Khaw, K-T. (Kay-Tee), Wareham, N.J. (Nick), Key, T. (Tim), Naska, A. (Androniki), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Masala, G. (Giovanna), Panico, S. (Salvatore), Contiero, P. (Paolo), Tumino, R. (Rosario), Bueno-De-Mesquita, H.B. (Bas), Siersema, P.D. (Peter), Peeters, P.H.M. (Petra), Zackrisson, S. (Sophia), Almquist, M. (Martin), Eriksson, S. (Sture), Hallmans, G. (Göran), Skeie, G. (Guri), Braaten, T. (Tonje), Lund, E. (Eiliv), Illner, A.-K. (Anne-Kathrin), Mouw, T. (Traci), Riboli, E. (Elio), Vineis, P. (Paolo), Gallo, V. (Valentina), Mackenbach, J.P. (Johan), Ezzati, M. (Majid), Menvielle, G. (Gwenn), Kunst, A.E. (Anton), Rohrmann, S. (Sabine), Kaaks, R. (Rudolf), Teucher, B. (Birgit), Boeing, H. (Heiner), Bergmann, M.M. (Manuela), Tjønneland, A. (Anne), Dalton, S.O. (Susanne), Overvad, K. (Kim), Redondo, M.-L. (Maria-Luisa), Agudo, A. (Antonio), Daponte, A. (Antonio), Arriola, L. (Larraitz), Navarro, C. (Carmen), Barricante Gurrea, A. (Aurelio), Khaw, K-T. (Kay-Tee), Wareham, N.J. (Nick), Key, T. (Tim), Naska, A. (Androniki), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Masala, G. (Giovanna), Panico, S. (Salvatore), Contiero, P. (Paolo), Tumino, R. (Rosario), Bueno-De-Mesquita, H.B. (Bas), Siersema, P.D. (Peter), Peeters, P.H.M. (Petra), Zackrisson, S. (Sophia), Almquist, M. (Martin), Eriksson, S. (Sture), Hallmans, G. (Göran), Skeie, G. (Guri), Braaten, T. (Tonje), Lund, E. (Eiliv), Illner, A.-K. (Anne-Kathrin), Mouw, T. (Traci), Riboli, E. (Elio), and Vineis, P. (Paolo)
Abstract: Background: Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. Methods: A total of 3,456,689 person/years follow-up of the European Prospective Investigation into Cancer and Nutrition (EPIC) was analysed. Educational level of subjects coming from 9 European countries was recorded as proxy for socio-economic status (SES). Cox proportional hazard model's with a step-wise inclusion of explanatory variables were used to explore the association between SES and mortality; a Relative Index of Inequality (RII) was calculated as measure of relative inequality. Results: Total mortality among men with the highest education level is reduced by 43% compared to men with the lowest (HR 0.57, 95% C.I. 0.52-0.61); among women by 29% (HR 0.71, 95% C.I. 0.64-0.78). The risk reduction was attenuated by 7% in men and 3% in women by the introduction of smoking and to a lesser extent (2% in men and 3% in women) by introducing body mass index and additional explanatory variables (alcohol consumption, leisure physical activity, fruit and vegetable intake) (3% in men and 5% in women). Social inequalities were highly statistically significant for all causes of death examined in men. In women, social inequalities were less strong, but statistically significant for all causes of death except for cancer-related mortality and injuries. Discussion: In this European study, substantial social inequalities in mortality among European men and women which cannot be fully explained away by accounting for known common risk factors for chronic diseases are reported.
Published: 2012
Full Text: View/download PDF

30. The contribution of risk factors to the higher incidence of invasive and in situ breast cancers in women with higher levels of education in the European prospective investigation into cancer and nutrition

Author: Menvielle, G. (Gwenn), Kunst, A.E. (Anton), Gils, C.H. (Carla) van, Peeters, P.H.M. (Petra), Boshuizen, H.C. (Hendriek), Overvad, K. (Kim), Olsen, A. (Anja), Tjonneland, A. (Anne), Hermann, S. (Silke), Kaaks, R. (Rudolf), Bergmann, M.M. (Manuela), Illner, A.-K. (Anne-Kathrin), Lagiou, P. (Pagona), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Palli, D. (Domenico), Berrino, F. (Franco), Mattiello, A. (Amelia), Tumino, R. (Rosario), Sacerdote, C. (Carlotta), May, A.M. (Anne), Monninkhof, E. (Evelyn), Braaten, T. (Tonje), Lund, E. (Eiliv), Quirós, J.R., Duell, E.J. (Eric), Sánchez, M.J., Navarro, C. (Carmen), Borgquist, S. (Signe), Manjer, J. (Jonas), Khaw, K-T. (Kay-Tee), Reeves, G.K. (Gillian), Chajes, V. (Véronique), Rinaldi, S. (Sabina), Slimani, N. (Nadia), Gallo, V. (Valentina), Vineis, P. (Paolo), Riboli, E. (Elio), Bueno-De-Mesquita, H.B. (Bas), Allen, N.E. (Naomi), Ardanaz, E. (Eva), Menvielle, G. (Gwenn), Kunst, A.E. (Anton), Gils, C.H. (Carla) van, Peeters, P.H.M. (Petra), Boshuizen, H.C. (Hendriek), Overvad, K. (Kim), Olsen, A. (Anja), Tjonneland, A. (Anne), Hermann, S. (Silke), Kaaks, R. (Rudolf), Bergmann, M.M. (Manuela), Illner, A.-K. (Anne-Kathrin), Lagiou, P. (Pagona), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Palli, D. (Domenico), Berrino, F. (Franco), Mattiello, A. (Amelia), Tumino, R. (Rosario), Sacerdote, C. (Carlotta), May, A.M. (Anne), Monninkhof, E. (Evelyn), Braaten, T. (Tonje), Lund, E. (Eiliv), Quirós, J.R., Duell, E.J. (Eric), Sánchez, M.J., Navarro, C. (Carmen), Borgquist, S. (Signe), Manjer, J. (Jonas), Khaw, K-T. (Kay-Tee), Reeves, G.K. (Gillian), Chajes, V. (Véronique), Rinaldi, S. (Sabina), Slimani, N. (Nadia), Gallo, V. (Valentina), Vineis, P. (Paolo), Riboli, E. (Elio), Bueno-De-Mesquita, H.B. (Bas), Allen, N.E. (Naomi), and Ardanaz, E. (Eva)
Abstract: The authors investigated the role of known risk factors in educational differences in breast cancer incidence. Analyses were based on the European Prospective Investigation Into Cancer and Nutrition and included 242,095 women, 433 cases of in situ breast cancer, and 4,469 cases of invasive breast cancer. Reproductive histo
Published: 2011
Full Text: View/download PDF

31. Occupational exposures contribute to educational inequalities in lung cancer incidence among men: Evidence from the EPIC prospective cohort study

Author: Menvielle, G. (Gwenn), Boshuizen, H.C. (Hendriek), Kunst, A.E. (Anton), Vineis, P. (Paolo), Dalton, S.O. (Susanne), Bergmann, M.M. (Manuela), Hermann, S. (Silke), Veglia, F. (Fabrizio), Ferrari, P. (Pietro), Overvad, K. (Kim), Raaschou-Nielsen, O. (Ole), Tjønneland, A. (Anne), Kaaks, R. (Rudolf), Linseisen, J. (Jakob), Palli, D. (Domenico), Krogh, V. (Vittorio), Tumino, R. (Rosario), Rodriguez, L. (Laudina), Agudo, A. (Antonio), Sánchez, M.J., Arozena, J.M.A., Cirera, L. (Lluis), Ardanaz, E. (Eva), Bingham, S. (Sheila), Khaw, K-T. (Kay-Tee), Boffetta, P. (Paolo), Duell, E.J. (Eric), Slimani, N. (Nadia), Gallo, V. (Valentina), Riboli, E. (Elio), Bueno-de-Mesquita, H.B. (Bas), Menvielle, G. (Gwenn), Boshuizen, H.C. (Hendriek), Kunst, A.E. (Anton), Vineis, P. (Paolo), Dalton, S.O. (Susanne), Bergmann, M.M. (Manuela), Hermann, S. (Silke), Veglia, F. (Fabrizio), Ferrari, P. (Pietro), Overvad, K. (Kim), Raaschou-Nielsen, O. (Ole), Tjønneland, A. (Anne), Kaaks, R. (Rudolf), Linseisen, J. (Jakob), Palli, D. (Domenico), Krogh, V. (Vittorio), Tumino, R. (Rosario), Rodriguez, L. (Laudina), Agudo, A. (Antonio), Sánchez, M.J., Arozena, J.M.A., Cirera, L. (Lluis), Ardanaz, E. (Eva), Bingham, S. (Sheila), Khaw, K-T. (Kay-Tee), Boffetta, P. (Paolo), Duell, E.J. (Eric), Slimani, N. (Nadia), Gallo, V. (Valentina), Riboli, E. (Elio), and Bueno-de-Mesquita, H.B. (Bas)
Abstract: The aim of this study is to investigate to what extent occupational exposures may explain socioeconomic inequalities in lung cancer incidence after adjusting for smoking and dietary factors. Analyses were based on a subsampie of the European Prospective Investigation into Cancer and Nutrition (EPIC study), a prospective cohort. The analyses included 703 incident lung cancer cases among men in Denmark, the United Kingdom, Germany, Italy, Spain and Greece. The socioeconomic position was measured using the highest level of education. The estimates of relative indices of inequality (Ril) were computed with Cox regression models. We first adjusted for smoking (with detailed information on duration and quantity) and dietary factors (fruits and vegetables consumption) and then for occupational exposures. The exposure to three carcinogens [asbestos, heavy metals and polycyclic aromatic hydrocarbons (PAH)] was analyzed. The occupational exposures explained 14% of the socioeconomic inequalities remaining after adjustment for smoking and fruits and vegetables consumption. The inequalities remained nevertheless statistically significant The RII decreased from 1.87 (95% Cl: 1.36-2.56) to 1.75 (1.27-2.41). The decrease was more pronounced when adjusting for asbestos than for heavy metals or PAH. Analyses by birth cohort suggested an effect of occupational exposures among older men, while due to smal
Published: 2010
Full Text: View/download PDF

32. The role of smoking and diet in explaining educational inequalities in lung cancer incidence

Author: Menvielle, G. (Gwenn), Boshuizen, H.C. (Hendriek), Kunst, A.E. (Anton), Dalton, S.O. (Susanne), Vineis, P. (Paolo), Bergmann, M.M. (Manuela), Hermann, S. (Silke), Ferrari, P. (Pietro), Raaschou-Nielsen, O. (Ole), Tjønneland, A. (Anne), Kaaks, R. (Rudolf), Linseisen, J. (Jakob), Kosti, M. (Maria), Trichopoulou, A. (Antonia), Dilis, V. (Vardis), Palli, D. (Domenico), Krogh, V. (Vittorio), Panico, S. (Salvatore), Tumino, R. (Rosario), Büchner, F.L. (Frederike), Gils, C.H. (Carla) van, Peeters, P.H.M., Braaten, T. (Tonje), Gram, I.T. (Inger), Lund, E. (Eiliv), Rodriguez, L. (Laudina), Agudo, A. (Antonio), Sánchez, M.J., Tormo, M.J., Ardanaz, E. (Eva), Manjer, J. (Jonas), Wirfält, E. (Elisabet), Hallmans, G. (Göran), Rasmuson, T. (Torgny), Bingham, S. (Sheila), Khaw, K-T. (Kay-Tee), Allen, N.E. (Naomi), Key, T. (Tim), Boffetta, P. (Paolo), Duell, E.J. (Eric), Slimani, N. (Nadia), Gallo, V. (Valentina), Riboli, E. (Elio), Bueno-De-Mesquita, H.B. (Bas), Menvielle, G. (Gwenn), Boshuizen, H.C. (Hendriek), Kunst, A.E. (Anton), Dalton, S.O. (Susanne), Vineis, P. (Paolo), Bergmann, M.M. (Manuela), Hermann, S. (Silke), Ferrari, P. (Pietro), Raaschou-Nielsen, O. (Ole), Tjønneland, A. (Anne), Kaaks, R. (Rudolf), Linseisen, J. (Jakob), Kosti, M. (Maria), Trichopoulou, A. (Antonia), Dilis, V. (Vardis), Palli, D. (Domenico), Krogh, V. (Vittorio), Panico, S. (Salvatore), Tumino, R. (Rosario), Büchner, F.L. (Frederike), Gils, C.H. (Carla) van, Peeters, P.H.M., Braaten, T. (Tonje), Gram, I.T. (Inger), Lund, E. (Eiliv), Rodriguez, L. (Laudina), Agudo, A. (Antonio), Sánchez, M.J., Tormo, M.J., Ardanaz, E. (Eva), Manjer, J. (Jonas), Wirfält, E. (Elisabet), Hallmans, G. (Göran), Rasmuson, T. (Torgny), Bingham, S. (Sheila), Khaw, K-T. (Kay-Tee), Allen, N.E. (Naomi), Key, T. (Tim), Boffetta, P. (Paolo), Duell, E.J. (Eric), Slimani, N. (Nadia), Gallo, V. (Valentina), Riboli, E. (Elio), and Bueno-De-Mesquita, H.B. (Bas)
Abstract: Background: Studies in many countries have reported higher lung cancer incidence and mortality in individuals with lower socioeconomic status. Methods: To investigate the role of smoking in these inequalities, we used data from 391 251 participants in the European Prospective Investigation into Cancer and Nutrition study, a cohort of individuals in 10 European countries. We collected informatio
Published: 2009
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources

Refine your results

32 results on '"Kaaks, R. (Rudolf)"'

1. Common variants in breast cancer risk loci predispose to distinct tumor subtypes

2. Rare germline copy number variants (CNVs) and breast cancer risk

3. CYP3A7*1C allele:linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

4. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

5. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

6. Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

7. Mendelian randomisation study of smoking exposure in relation to breast cancer risk

8. Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

9. Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

10. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis

11. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

12. Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

13. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

14. A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

15. Genome-wide association study of germline variants and breast cancer-specific mortality

16. Polygenic risk scores for prediction of breast cancer and breast cancer subtypes

17. Risk thresholds for alcohol consumption:combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

18. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

19. Body mass index and breast cancer survival:a Mendelian randomization analysis

20. Body mass index and breast cancer survival

21. Worldwide trends in blood pressure from 1975 to 2015:a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

22. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

23. A century of trends in adult human height

24. Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants

25. A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

26. Identification of novel genetic markers of breast cancer survival

27. Common germline polymorphisms associated with breast cancer-specific survival

28. Rare coding variants and X-linked loci associated with age at menarche

29. Social inequalities and mortality in europe - results from a large multi-national cohort

30. The contribution of risk factors to the higher incidence of invasive and in situ breast cancers in women with higher levels of education in the European prospective investigation into cancer and nutrition

31. Occupational exposures contribute to educational inequalities in lung cancer incidence among men: Evidence from the EPIC prospective cohort study

32. The role of smoking and diet in explaining educational inequalities in lung cancer incidence

Catalog

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Database

Publisher

32 results on '"Kaaks, R. (Rudolf)"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources