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198 results on '"Kaba Dramane"'

1. Tsetse fly ecology and risk of transmission of African trypanosomes related to a protected forest area at a military base in the city of Abidjan, Côte d’Ivoire

Author

Konan Yao Jean Rodrigue, Berté Djakaridja, Ta Bi Tra Dieudonné, Demoncheaux Jean-Paul, Sauzet Sylvie, Watier-Grillot Stéphanie, Kouadio Koffi Alain De Marie, N’dri Louis, Coulibaly Bamoro, Solano Philippe, Ravel Sophie, Ségard Adeline, Kaba Dramane, De Meeûs Thierry, Djohan Vincent, and Jamonneau Vincent

Subjects
glossina palpalis palpalis, trypanosoma, ecology, vector control, abidjan, côte d’ivoire, Infectious and parasitic diseases, RC109-216
Abstract

African trypanosomoses, whose pathogens are transmitted by tsetse flies, are a threat to animal and human health. Tsetse flies observed at the military base of the French Forces in Côte d’Ivoire (FFCI base) were probably involved in the infection and death of military working dogs. Entomological and parasitological surveys were carried out during the rainy and dry seasons using “Vavoua” traps to identify tsetse fly species, their distribution, favorable biotopes and food sources, as well as the trypanosomes they harbor. A total of 1185 Glossina palpalis palpalis tsetse flies were caught, corresponding to a high average apparent density of 2.26 tsetse/trap/day. The results showed a heterogeneous distribution of tsetse at the FFCI base, linked to more or less favorable biotopes. No significant variation in tsetse densities was observed according to the season. The overall trypanosomes infection rate according to microscopic observation was 13.5%. Polymerase chain reaction (PCR) analyses confirmed the presence of Trypanosoma vivax and T. congolense forest type, responsible for African animal trypanosomosis. Our findings suggest that there is a risk of introduction and transmission of T. brucei gambiense, responsible for human African trypanosomiasis, on the study site. This risk of transmission of African trypanosomes concerns not only the FFCI base, but also inhabited peripheral areas. Our study confirmed the need for vector control adapted to the eco-epidemiological context of the FFCI base.

Published
2023
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2. Monitoring the elimination of gambiense human African trypanosomiasis in the historical focus of Batié, South–West Burkina Faso

Author

Compaoré Charlie Franck Alfred, Kaboré Jacques, Ilboudo Hamidou, Thomas Lian Francesca, Falzon Laura Cristina, Bamba Mohamed, Sakande Hassane, Koné Minayégninrin, Kaba Dramane, Bougouma Clarisse, Adama Ilboudo, Amathe Ouedraogo, Belem Adrien Marie Gaston, Fèvre Eric Maurice, Büscher Philippe, Lejon Veerle, and Jamonneau Vincent

Subjects
human african trypanosomiasis, trypanosoma brucei gambiense, elimination, diagnosis, rapid diagnostic test, specificity, dried blood spot, burkina faso, Infectious and parasitic diseases, RC109-216
Abstract

The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection of re-emergent cases. In this context, the performance of diagnostic tests and testing algorithms for detection of the re-emergence of Trypanosoma brucei gambiense HAT remains to be assessed. We carried out a door-to-door active medical survey for HAT in the historical focus of Batié, South–West Burkina Faso. Screening was done using three rapid diagnostic tests (RDTs). Two laboratory tests (ELISA/T. b. gambiense and immune trypanolysis) and parasitological examination were performed on RDT positives only. In total, 5883 participants were screened, among which 842 (14%) tested positive in at least one RDT. Blood from 519 RDT positives was examined microscopically but no trypanosomes were observed. The HAT Sero-K-Set test showed the lowest specificity of 89%, while the specificities of SD Bioline HAT and rHAT Sero-Strip were 92% and 99%, respectively. The specificity of ELISA/T. b. gambiense and trypanolysis was 99% (98–99%) and 100% (99–100%), respectively. Our results suggest that T. b. gambiense is no longer circulating in the study area and that zero transmission has probably been attained. While a least cost analysis is still required, our study showed that RDT preselection followed by trypanolysis may be a useful strategy for post-elimination surveillance in Burkina Faso.

Published
2022
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3. Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance study

Author

N’Djetchi, Martial Kassi, Camara, Oumou, Koffi, Mathurin, Camara, Mamadou, Kaba, Dramane, Kaboré, Jacques, Tall, Alkali, Rotureau, Brice, Glover, Lucy, Traoré, Mélika Barkissa, Koné, Minayegninrin, Coulibaly, Bamoro, Adingra, Guy Pacome, Soumah, Aissata, Gassama, Mohamed, Camara, Abdoulaye Dansy, Compaoré, Charlie Franck Alfred, Camara, Aïssata, Boiro, Salimatou, Anton, Elena Perez, Bessell, Paul, Van Reet, Nick, Bucheton, Bruno, Jamonneau, Vincent, Bart, Jean-Mathieu, Solano, Philippe, Biéler, Sylvain, and Lejon, Veerle

Published
2024
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4. Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis

Author

Dama Emilie, Camara Oumou, Kaba Dramane, Koffi Mathurin, Camara Mamadou, Compaoré Charlie, Ilboudo Hamidou, Courtin Fabrice, Kaboré Jacques, N’Gouan Emmanuel Kouassi, Büscher Philippe, Lejon Veerle, Bucheton Bruno, and Jamonneau Vincent

Subjects
human african trypanosomiasis, trypanosoma brucei gambiense, elimination, diagnosis, transmission, immune trypanolysis, Infectious and parasitic diseases, RC109-216
Abstract

The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area.

Published
2019
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5. A targeted door-to-door strategy for sleeping sickness detection in low-prevalence settings in Côte d’Ivoire

Author

Koffi Mathurin, N’Djetchi Martial, Ilboudo Hamidou, Kaba Dramane, Coulibaly Bamoro, N’Gouan Emmanuel, Kouakou Lingué, Bucheton Bruno, Solano Philippe, Courtin Fabrice, Ehrhardt Stephan, and Jamonneau Vincent

Subjects
Human African trypanosomiasis, Trypanosoma brucei gambiense, Diagnosis, Elimination strategy, Côte d’Ivoire, Medical survey, Infectious and parasitic diseases, RC109-216
Abstract

Significant efforts to control human African trypanosomiasis (HAT) over the three past decades have resulted in drastic reductions of disease prevalence in Côte d’Ivoire. In this context, the costly and labor-intensive active mass screening strategy is no longer efficient. In addition to a more cost-effective passive surveillance system being implemented in this low-prevalence context, our aim was to develop an alternative targeted active screening strategy. In 2012, we carried out a targeted door-to-door (TDD) survey focused on the immediate vicinities of former HAT patients detected in the HAT focus of Bonon and compared the results to those obtained during classical active mass screening (AMS) surveys conducted from 2000 to 2012 in the same area. The TDD that provides a friendlier environment, inviting inhabitants to participate and gain awareness of the disease, detected significantly more HAT cases than the AMS. These results suggest that the TDD is an efficient and useful strategy in low-prevalence settings where very localized transmission cycles may persist and, in combination with passive surveillance, could help in eliminating HAT.

Published
2016
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6. Detection and identification of pathogenic trypanosome species in tsetse flies along the Comoé River in Côte d’Ivoire

Author

Djohan Vincent, Kaba Dramane, Rayaissé Jean-Baptiste, Dayo Guiguigbaza-Kossigan, Coulibaly Bamoro, Salou Ernest, Dofini Fabien, Kouadio Alain De Marie Koffi, Menan Hervé, and Solano Philippe

Subjects
Trypanosomes, Trypanosomiasis, Riverine tsetse flies, Côte d’Ivoire, Infectious and parasitic diseases, RC109-216
Abstract

In order to identify pathogenic trypanosomes responsible for African trypanosomiasis, and to better understand tsetse-trypanosome relationships, surveys were undertaken in three sites located in different eco-climatic areas in Côte d’Ivoire during the dry and rainy seasons. Tsetse flies were caught during five consecutive days using biconical traps, dissected and microscopically examined looking for trypanosome infection. Samples from infected flies were tested by PCR using specific primers for Trypanosoma brucei s.l., T. congolense savannah type, T. congolense forest type and T. vivax. Of 1941 tsetse flies caught including four species, i.e. Glossina palpalis palpalis, G. p. gambiensis, G. tachinoides and G. medicorum, 513 (26%) were dissected and 60 (12%) were found positive by microscopy. Up to 41% of the infections were due to T. congolense savannah type, 30% to T. vivax, 20% to T. congolense forest type and 9% due to T. brucei s.l. All four trypanosome species and subgroups were identified from G. tachinoides and G. p. palpalis, while only two were isolated from G. p. gambiensis (T. brucei s.l., T. congolense savannah type) and G. medicorum (T. congolense forest, savannah types). Mixed infections were found in 25% of cases and all involved T. congolense savannah type with another trypanosome species. The simultaneous occurrence of T. brucei s.l., and tsetse from the palpalis group may suggest that human trypanosomiasis can still be a constraint in these localities, while high rates of T. congolense and T. vivax in the area suggest a potential risk of animal trypanosomiasis in livestock along the Comoé River.

Published
2015
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7. Phenetic and genetic structure of tsetse fly populations (Glossina palpalis palpalis) in southern Ivory Coast

Author

Kaba Dramane, Ravel Sophie, Acapovi-Yao Geneviève, Solano Philippe, Allou Koffi, Bosson-Vanga Henriette, Gardes Laetitia, N’Goran Eliezer, Schofield Christopher, Koné Moussa, and Dujardin Jean-Pierre

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Sleeping sickness, transmitted by G. p. palpalis, is known to be present in the Ivory Coast. G. p. palpalis has recently been reported to occur in several places within the town of Abidjan, including: (i) the Banco forest, (ii) the Abobo Adjamé University campus and (iii) the zoological park. Could these three places be treated sequentially, as separate tsetse populations, or should they be taken as one area comprising a single, panmictic population? Methods The amount of gene flow between these places provides strategic information for vector control. It was estimated by the use of both microsatellite DNA and morphometric markers. The idea was to assess the interest of the faster and much less expensive morphometric approach in providing relevant information about population structure. Thus, to detect possible lack of insect exchange between these neighbouring areas of Abidjan, we used both genetic (microsatellite DNA) and phenetic (geometric morphometrics) markers on the same specimens. Using these same markers, we also compared these samples with specimens from a more distant area of south Ivory Coast, the region of Aniassué (186 km north from Abidjan). Results Neither genetic nor phenetic markers detected significant differentiation between the three Abidjan G. p. palpalis samples. Thus, the null hypothesis of a single panmictic population within the city of Abidjan could not be rejected, suggesting the control strategy should not consider them separately. The markers were also in agreement when comparing G. p. palpalis from Abidjan with those of Aniassué, showing significant divergence between the two sites. Conclusions Both markers suggested that a successful control of tsetse in Abidjan would require the three Abidjan sites to be considered together, either by deploying control measures simultaneously in all three sites, or by a continuous progression of interventions following for instance the "rolling carpet" principle. To compare the geometry of wing venation of tsetse flies is a cheap and fast technique. Agreement with the microsatellite approach highlights its potential for rapid assessment of population structure.

Published
2012
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8. The exchangeability of shape

Author

Kaba Dramane, Dujardin Jean-Pierre AL, and Henry Amy B

Subjects
Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Landmark based geometric morphometrics (GM) allows the quantitative comparison of organismal shapes. When applied to systematics, it is able to score shape changes which often are undetectable by traditional morphological studies and even by classical morphometric approaches. It has thus become a fast and low cost candidate to identify cryptic species. Due to inherent mathematical properties, shape variables derived from one set of coordinates cannot be compared with shape variables derived from another set. Raw coordinates which produce these shape variables could be used for data exchange, however they contain measurement error. The latter may represent a significant obstacle when the objective is to distinguish very similar species. Results We show here that a single user derived dataset produces much less classification error than a multiple one. The question then becomes how to circumvent the lack of exchangeability of shape variables while preserving a single user dataset. A solution to this question could lead to the creation of a relatively fast and inexpensive systematic tool adapted for the recognition of cryptic species. Conclusions To preserve both exchangeability of shape and a single user derived dataset, our suggestion is to create a free access bank of reference images from which one can produce raw coordinates and use them for comparison with external specimens. Thus, we propose an alternative geometric descriptive system that separates 2-D data gathering and analyzes.

Published
2010
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10. Analytical sensitivity of loopamp and quantitative real-time PCR on dried blood spots and their potential role in monitoring human African trypanosomiasis elimination

Author

Alfred Compaoré, Charlie Franck, Ilboudo, Hamidou, Kaboré, Jacques, Kaboré, Justin Windingoudi, Camara, Oumou, Bamba, Mohamed, Sakande, Hassane, Koné, Minayégninrin, Camara, Mamadou, Kaba, Dramane, Gaston Belem, Adrien Marie, Deborggraeve, Stijn, Büscher, Philippe, Bucheton, Bruno, Lejon, Veerle, and Jamonneau, Vincent

Published
2020
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12. Low specificity of rapid diagnostic tests and lack of coherence between laboratory tests to diagnose gambiense human African trypanosomiasis, as evidenced by a prospective clinical performance study in Côte d’Ivoire and in Guinea

Author

N’Djetchi, Martial Kassi, primary, Camara, Oumou, additional, Koffi, Mathurin, additional, Camara, Mamadou, additional, Kaba, Dramane, additional, Kaboré, Jacques, additional, Tall, Alkali, additional, Rotureau, Brice, additional, Glover, Lucy, additional, Traoré, Mélika Barkissa, additional, Koné, Minayegninrin, additional, Coulibaly, Bamoro, additional, Adingra, Guy Pacome, additional, Soumah, Aissata, additional, Gassama, Mohamed, additional, Camara, Abdoulaye Dansy, additional, Compaoré, Charlie Franck Alfred, additional, Camara, Aïssata, additional, Boiro, Salimatou, additional, Anton, Elena Perez, additional, Bessell, Paul, additional, Reet, Nick Van, additional, Bucheton, Bruno, additional, Jamonneau, Vincent, additional, Bart, Jean-Mathieu, additional, Solano, Philippe, additional, Biéler, Sylvain, additional, and Lejon, Veerle, additional

Published
2024
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15. Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance study.

Author

N'Djetchi, Martial Kassi, Camara, Oumou, Koffi, Mathurin, Camara, Mamadou, Kaba, Dramane, Kaboré, Jacques, Tall, Alkali, Rotureau, Brice, Glover, Lucy, Traoré, Mélika Barkissa, Koné, Minayegninrin, Coulibaly, Bamoro, Adingra, Guy Pacome, Soumah, Aissata, Gassama, Mohamed, Camara, Abdoulaye Dansy, Compaoré, Charlie Franck Alfred, Camara, Aïssata, Boiro, Salimatou, and Anton, Elena Perez

Subjects
AFRICAN trypanosomiasis, IMMUNOSPECIFICITY, RAPID diagnostic tests, TESTING laboratories, MEDICAL screening
Abstract

Background: Serological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis (gHAT). Presently, they preselect individuals for microscopic confirmation, but in future "screen and treat" strategies they will identify individuals for treatment. Variability in reported specificities, the development of new rapid diagnostic tests (RDT) and the hypothesis that malaria infection may decrease RDT specificity led us to evaluate the specificity of 5 gHAT screening tests. Methods: During active screening, venous blood samples from 1095 individuals from Côte d'Ivoire and Guinea were tested consecutively with commercial (CATT, HAT Sero-K-SeT, Abbott Bioline HAT 2.0) and prototype (DCN HAT RDT, HAT Sero-K-SeT 2.0) gHAT screening tests and with a malaria RDT. Individuals with ≥ 1 positive gHAT screening test underwent microscopy and further immunological (trypanolysis with T.b. gambiense LiTat 1.3, 1.5 and 1.6; indirect ELISA/T.b. gambiense; T.b. gambiense inhibition ELISA with T.b. gambiense LiTat 1.3 and 1.5 VSG) and molecular reference laboratory tests (PCR TBRN3, 18S and TgsGP; SHERLOCK 18S Tids, 7SL Zoon, and TgsGP; Trypanozoon S2-RT-qPCR 18S2, 177T, GPI-PLC and TgsGP in multiplex; RT-qPCR DT8, DT9 and TgsGP in multiplex). Microscopic trypanosome detection confirmed gHAT, while other individuals were considered gHAT free. Differences in fractions between groups were assessed by Chi square and differences in specificity between 2 tests on the same individuals by McNemar. Results: One gHAT case was diagnosed. Overall test specificities (n = 1094) were: CATT 98.9% (95% CI: 98.1–99.4%); HAT Sero-K-SeT 86.7% (95% CI: 84.5–88.5%); Bioline HAT 2.0 82.1% (95% CI: 79.7–84.2%); DCN HAT RDT 78.2% (95% CI: 75.7–80.6%); and HAT Sero-K-SeT 2.0 78.4% (95% CI: 75.9–80.8%). In malaria positives, gHAT screening tests appeared less specific, but the difference was significant only in Guinea for Abbott Bioline HAT 2.0 (P = 0.03) and HAT Sero-K-Set 2.0 (P = 0.0006). The specificities of immunological and molecular laboratory tests in gHAT seropositives were 98.7–100% (n = 399) and 93.0–100% (n = 302), respectively. Among 44 reference laboratory test positives, only the confirmed gHAT patient and one screening test seropositive combined immunological and molecular reference laboratory test positivity. Conclusions: Although a minor effect of malaria cannot be excluded, gHAT RDT specificities are far below the 95% minimal specificity stipulated by the WHO target product profile for a simple diagnostic tool to identify individuals eligible for treatment. Unless specificity is improved, an RDT-based "screen and treat" strategy would result in massive overtreatment. In view of their inconsistent results, additional comparative evaluations of the diagnostic performance of reference laboratory tests are indicated for better identifying, among screening test positives, those at increased suspicion for gHAT. Trial registration: The trial was retrospectively registered under NCT05466630 in clinicaltrials.gov on July 15 2022. [ABSTRACT FROM AUTHOR]

Published
2024
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16. OA-765 Molecular diagnostic tests specificities and their contribution for HAT postelimination monitoring in Burkina Faso and Côte d’Ivoire

Author

Alfred Compaoré, Charlie Franck, primary, Koné, Minayégninrin, additional, Kaboré, Jacques, additional, Ilboudo, Hamidou, additional, Bamba, Mohamed, additional, Sakande, Hassane, additional, Kaba, Dramane, additional, Gaston Belem, Adrien Marie, additional, Büscher, Philippe, additional, Lejon, Veerle, additional, and Jamonneau, Vincent, additional

Published
2023
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17. PA-80 Specificity of serological screening tests for diagnosis of gambiense human African trypanosomiasis in Côte d’Ivoire and Guinea

Author

Kassi N’Djetchi, Martial, primary, Camara, Oumou, additional, Koffi, Mathurin, additional, Camara, Mamadou, additional, Kaba, Dramane, additional, Barkissa Mélika, Traoré, additional, Koné, Minayégninrin, additional, Coulibaly, Bamoro, additional, Pacôme Adingra, Guy, additional, Soumah, Aissata, additional, Diaby Gassama, Mohamed, additional, Dansy Camara, Abdoulaye, additional, Bucheton, Bruno, additional, Jamonneau, Vincent, additional, Bart, Jean-Mathieu, additional, Biéler, Sylvain, additional, and Lejon, Veerle, additional

Published
2023
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19. Population genetics of Trypanosoma brucei gambiense, the agent of sleeping sickness in Western Africa

Author

Koffi, Mathurin, De Meeûs, Thierry, Bucheton, Bruno, Solano, Philippe, Camara, Mamadou, Kaba, Dramane, Cuny, Gérard, Ayala, Francisco J, and Jamonneau, Vincent

Subjects
Rare Diseases, Genetics, Vector-Borne Diseases, Infectious Diseases, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Africa, Western, Animals, Cote d'Ivoire, Genetic Variation, Genetics, Population, Guinea, Humans, Microsatellite Repeats, Topography, Medical, Trypanosoma brucei gambiense, Trypanosomiasis, African, clonality, effective population size, genetic differentiation, genetic diversity, microsatellite markers
Abstract

Human African trypanosomiasis, or sleeping sickness caused by Trypanosoma brucei gambiense, occurs in Western and Central Africa. T. brucei s.l. displays a huge diversity of adaptations and host specificities, and questions about its reproductive mode, dispersal abilities, and effective size remain under debate. We have investigated genetic variation at 8 microsatellite loci of T. b. gambiense strains isolated from human African trypanosomiasis patients in the Ivory Coast and Guinea, with the aim of knowing how genetic information was partitioned within and between individuals in both temporal and spatial scales. The results indicate that (i) migration of T. b. gambiense group 1 strains does not occur at the scale of West Africa, and that even at a finer scale (e.g., within Guinea) migration is restricted; (ii) effective population sizes of trypanosomes, as reflected by infected hosts, are probably higher than what the epidemiological surveys suggest; and (iii) T. b. gambiense group 1 is most likely a strictly clonally reproducing organism.

Published
2009

20. Towards the sustainable elimination of gambiense human African trypanosomiasis in Côte d’Ivoire using an integrated approach

Author

Kaba, Dramane, primary, Koffi, Mathurin, additional, Kouakou, Lingué, additional, N’Gouan, Emmanuel Kouassi, additional, Djohan, Vincent, additional, Courtin, Fabrice, additional, N’Djetchi, Martial Kassi, additional, Coulibaly, Bamoro, additional, Adingra, Guy Pacôme, additional, Berté, Djakaridja, additional, Ta, Bi Tra Dieudonné, additional, Koné, Minayégninrin, additional, Traoré, Barkissa Mélika, additional, Sutherland, Samuel A., additional, Crump, Ronald E., additional, Huang, Ching-I, additional, Madan, Jason, additional, Bessell, Paul R., additional, Barreaux, Antoine, additional, Solano, Philippe, additional, Crowley, Emily H., additional, Rock, Kat S., additional, and Jamonneau, Vincent, additional

Published
2023
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21. Towards the sustainable elimination of gambiense human African trypanosomiasis in Côte d'Ivoire using an integrated approach

Author

Kaba, Dramane, Koffi, Mathurin, Kouakou, Lingué, N'Gouan Kouassi, Emmanuel, Djohan, Vincent, Courtin, Fabrice, N'Djetchi, Martial Kassi, Coulibaly, Bamoro, Adingra, Guy Pacôme, Berté, Djakaridja, Ta, Bi Tra Dieudonné, Koné, Minayégninrin, Traoré, Barkissa Mélika, Sutherland, Samuel A., Crump, Ronald E., Huang, Ching-I, Madan, Jason, Bessell, Paul R., Barreaux, Antoine, Solano, Philippe, Crowley, Emily H., Rock, Kat S., Jamonneau, Vincent, Kaba, Dramane, Koffi, Mathurin, Kouakou, Lingué, N'Gouan Kouassi, Emmanuel, Djohan, Vincent, Courtin, Fabrice, N'Djetchi, Martial Kassi, Coulibaly, Bamoro, Adingra, Guy Pacôme, Berté, Djakaridja, Ta, Bi Tra Dieudonné, Koné, Minayégninrin, Traoré, Barkissa Mélika, Sutherland, Samuel A., Crump, Ronald E., Huang, Ching-I, Madan, Jason, Bessell, Paul R., Barreaux, Antoine, Solano, Philippe, Crowley, Emily H., Rock, Kat S., and Jamonneau, Vincent

Abstract

Background: Human African trypanosomiasis is a parasitic disease caused by trypanosomes among which Trypanosoma brucei gambiense is responsible for a chronic form (gHAT) in West and Central Africa. Its elimination as a public health problem (EPHP) was targeted for 2020. Côte d'Ivoire was one of the first countries to be validated by WHO in 2020 and this was particularly challenging as the country still reported around a hundred cases a year in the early 2000s. This article describes the strategies implemented including a mathematical model to evaluate the reporting results and infer progress towards sustainable elimination. Methods: The control methods used combined both exhaustive and targeted medical screening strategies including the follow-up of seropositive subjects– considered as potential asymptomatic carriers to diagnose and treat cases– as well as vector control to reduce the risk of transmission in the most at-risk areas. A mechanistic model was used to estimate the number of underlying infections and the probability of elimination of transmission (EoT) was met between 2000–2021 in two endemic and two hypo-endemic health districts. Results: Between 2015 and 2019, nine gHAT cases were detected in the two endemic health districts of Bouaflé and Sinfra in which the number of cases/10,000 inhabitants was far below 1, a necessary condition for validating EPHP. Modelling estimated a slow but steady decline in transmission across the health districts, bolstered in the two endemic health districts by the introduction of vector control. The decrease in underlying transmission in all health districts corresponds to a high probability that EoT has already occurred in Côte d'Ivoire. Conclusion: This success was achieved through a multi-stakeholder and multidisciplinary one health approach where research has played a major role in adapting tools and strategies to this large epidemiological transition to a very low prevalence. This integrated approach will need to conti

Published
2023

22. Vers l'élimination de la maladie du sommeil

Author

Solano, Philippe, Courtin, Fabrice, Kaba, Dramane, Camara, Mahmoud, Kagbadouno, Moise S., Rayaissé, Jean-Baptiste, Jamonneau, Vincent, Bucheton, Bruno, Bart, Jean-Mathieu, Thevenon, Sophie, Lejon, Veerle, Solano, Philippe, Courtin, Fabrice, Kaba, Dramane, Camara, Mahmoud, Kagbadouno, Moise S., Rayaissé, Jean-Baptiste, Jamonneau, Vincent, Bucheton, Bruno, Bart, Jean-Mathieu, Thevenon, Sophie, and Lejon, Veerle

Abstract

La maladie du sommeil, ou trypanosomiase humaine africaine (THA), est due à Trypanosoma brucei transmis par la glossine ou mouche tsé-tsé. Après avoir ravagé l'Afrique subsaharienne dans la première moitié du XXe siècle, comme en témoigne l'extraordinaire ouvrage d'Alphonse Laveran et Félix Mesnil en 1912 (Trypanosomes et trypanosomiases), la THA, maladie tropicale négligée mortelle, dite " du bout de la piste " et pour laquelle il n'existe pas de vaccin, semble aujourd'hui à portée de main de l'élimination. Nous passons en revue les stratégies, activités et outils qui ont permis cette forte réduction du fardeau sanitaire pour les populations d'Afrique subsaharienne : environ 300 000 cas estimés dans les années 1990 contre moins de 1000 cas rapportés annuellement depuis 2018. La lutte contre la maladie du sommeil consiste principalement à dépister et traiter les cas ainsi qu'à lutter contre la glossine vectrice pour casser le cycle de transmission. En passant en 30 ans d'un contexte épidémique à un contexte d'élimination, la maladie du sommeil a subi une transition épidémiologique sans précédent à laquelle les stratégies et les outils de lutte ont dû s'adapter. Nous montrons comment la recherche a soutenu ces efforts et examinons certains des défis restants pour rendre effective et durable son élimination.

Published
2023

23. Towards the sustainable elimination of human African trypanosomiasis in Côte d’Ivoire using an integrated approach

Author

Kaba, Dramane, primary, Koffi, Mathurin, additional, Kouakou, Lingué, additional, N’Gouan, Emmanuel Kouassi, additional, Djohan, Vincent, additional, Courtin, Fabrice, additional, N’Djetchi, Martial Kassi, additional, Coulibaly, Bamoro, additional, Pacôme Adingra, Guy, additional, Berté, Djakaridja, additional, Dieudonné Ta, Bi Tra, additional, Koné, Minayégninrin, additional, Sutherland, Samuel A, additional, Crump, Ron E, additional, Huang, Ching-I, additional, Madan, Jason, additional, Bessell, Paul R, additional, Barreaux, Antoine, additional, Solano, Philippe, additional, Crowley, Emily H, additional, Rock, Kat S, additional, and Jamonneau, Vincent, additional

Published
2023
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25. The COMBAT project: controlling and progressively minimizing the burden of vector-borne animal trypanosomosis in Africa

Author

Boulangé, Alain, primary, Lejon, Veerle, additional, Berthier, David, additional, Thévenon, Sophie, additional, Gimonneau, Geoffrey, additional, Desquesnes, Marc, additional, Abah, Samuel, additional, Agboho, Prudenciène, additional, Chilongo, Kalinga, additional, Gebre, Tsegaye, additional, Fall, Assane Gueye, additional, Kaba, Dramane, additional, Magez, Stefan, additional, Masiga, Daniel, additional, Matovu, Enock, additional, Moukhtar, Aldjibert, additional, Neves, Luis, additional, Olet, Pamela A., additional, Pagabeleguem, Soumaïla, additional, Shereni, William, additional, Sorli, Brice, additional, Taioe, Moeti O., additional, Tejedor Junco, María Teresa, additional, Yagi, Rehab, additional, Solano, Philippe, additional, and Cecchi, Giuliano, additional

Published
2022
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26. The COMBAT project: Controlling and progressively minimizing the burden of vector-borne animal trypanosomosis in Africa

Author

Boulangé, Alain, Lejon, Veerle, Berthier, David, Thevenon, Sophie, Gimonneau, Geoffrey, Desquesnes, Marc, Abah, Samuel, Agboho, Prudenciène, Chilongo, Kalinga, Gebre, Tsegaye, Gueye Fall, Assane, Kaba, Dramane, Magez, Stefan, Masiga, Daniel, Matovu, Enock, Moukhtar, Aldjibert, Neves, Luis, Olet, Pamela A., Pagabeleguem, Soumaila, Shereni, William, Sorli, Brice, Taioe, Moeti O., Tejedor Junco, María Teresa, Yagi, Rehab, Solano, Philippe, Cecchi, Giuliano, Boulangé, Alain, Lejon, Veerle, Berthier, David, Thevenon, Sophie, Gimonneau, Geoffrey, Desquesnes, Marc, Abah, Samuel, Agboho, Prudenciène, Chilongo, Kalinga, Gebre, Tsegaye, Gueye Fall, Assane, Kaba, Dramane, Magez, Stefan, Masiga, Daniel, Matovu, Enock, Moukhtar, Aldjibert, Neves, Luis, Olet, Pamela A., Pagabeleguem, Soumaila, Shereni, William, Sorli, Brice, Taioe, Moeti O., Tejedor Junco, María Teresa, Yagi, Rehab, Solano, Philippe, and Cecchi, Giuliano

Abstract

Vector-borne diseases affecting livestock have serious impacts in Africa. Trypanosomosis is caused by parasites transmitted by tsetse flies and other blood-sucking Diptera. The animal form of the disease is a scourge for African livestock keepers, is already present in Latin America and Asia, and has the potential to spread further. A human form of the disease also exists, known as human African trypanosomosis or sleeping sickness. Controlling and progressively minimizing the burden of animal trypanosomosis (COMBAT) is a four-year research and innovation project funded by the European Commission, whose ultimate goal is to reduce the burden of animal trypanosomosis (AT) in Africa. The project builds on the progressive control pathway (PCP), a risk-based, step-wise approach to disease reduction or elimination. COMBAT will strengthen AT control and prevention by improving basic knowledge of AT, developing innovative control tools, reinforcing surveillance, rationalizing control strategies, building capacity, and raising awareness. Knowledge gaps on disease epidemiology, vector ecology and competence, and biological aspects of trypanotolerant livestock will be addressed. Environmentally friendly vector control technologies and more effective and adapted diagnostic tools will be developed. Surveillance will be enhanced by developing information systems, strengthening reporting, and mapping and modelling disease risk in Africa and beyond. The socio-economic burden of AT will be assessed at a range of geographical scales. Guidelines for the PCP and harmonized national control strategies and roadmaps will be developed. Gender equality and ethics will be pivotal in all project activities. The COMBAT project benefits from the expertise of African and European research institutions, national veterinary authorities, and international organizations. The project consortium comprises 21 participants, including a geographically balanced representation from 13 African countries, and

Published
2022

27. The COMBAT project: Controlling and progressively minimizing the burden of vector-borne animal trypanosomosis in Africa [version 2; peer review: 3 approved]

Author

Boulangé, Alain, Lejon, Veerle, Berthier, David, Thevenon, Sophie, Gimonneau, Geoffrey, Desquesnes, Marc, Abah, Samuel, Agboho, Prudenciène, Chilongo, Kalinga, Gebre, Tsegaye, Gueye Fall, Assane, Kaba, Dramane, Magez, Stefan, Masiga, Daniel, Matovu, Enock, Moukhtar, Aldjibert, Neves, Luis, Olet, Pamela A., Pagabeleguem, Soumaila, Shereni, William, Sorli, Brice, Taioe, Moeti O., Tejedor Junco, María Teresa, Yagi, Rehab, Solano, Philippe, Cecchi, Giuliano, Boulangé, Alain, Lejon, Veerle, Berthier, David, Thevenon, Sophie, Gimonneau, Geoffrey, Desquesnes, Marc, Abah, Samuel, Agboho, Prudenciène, Chilongo, Kalinga, Gebre, Tsegaye, Gueye Fall, Assane, Kaba, Dramane, Magez, Stefan, Masiga, Daniel, Matovu, Enock, Moukhtar, Aldjibert, Neves, Luis, Olet, Pamela A., Pagabeleguem, Soumaila, Shereni, William, Sorli, Brice, Taioe, Moeti O., Tejedor Junco, María Teresa, Yagi, Rehab, Solano, Philippe, and Cecchi, Giuliano

Abstract

Vector-borne diseases affecting livestock have serious impacts in Africa. Trypanosomosis is caused by parasites transmitted by tsetse flies and other blood-sucking Diptera. The animal form of the disease is a scourge for African livestock keepers, is already present in Latin America and Asia, and has the potential to spread further. A human form of the disease also exists, known as human African trypanosomosis or sleeping sickness. Controlling and progressively minimizing the burden of animal trypanosomosis (COMBAT) is a four-year research and innovation project funded by the European Commission, whose ultimate goal is to reduce the burden of animal trypanosomosis (AT) in Africa. The project builds on the progressive control pathway (PCP), a risk-based, step-wise approach to disease reduction or elimination. COMBAT will strengthen AT control and prevention by improving basic knowledge of AT, developing innovative control tools, reinforcing surveillance, rationalizing control strategies, building capacity, and raising awareness. Knowledge gaps on disease epidemiology, vector ecology and competence, and biological aspects of trypanotolerant livestock will be addressed. Environmentally friendly vector control technologies and more effective and adapted diagnostic tools will be developed. Surveillance will be enhanced by developing information systems, strengthening reporting, and mapping and modelling disease risk in Africa and beyond. The socio-economic burden of AT will be assessed at a range of geographical scales. Guidelines for the PCP and harmonized national control strategies and roadmaps will be developed. Gender equality and ethics will be pivotal in all project activities. The COMBAT project benefits from the expertise of African and European research institutions, national veterinary authorities, and international organizations. The project consortium comprises 21 participants, including a geographically balanced representation from 13 African countries, and

Published
2022

29. Free-ranging pigs identified as a multi-reservoir of Trypanosoma brucei and Trypanosoma congolense in the Vavoua area, a historical sleeping sickness focus of Côte d’Ivoire

Author

Traoré, Barkissa Mélika, primary, Koffi, Mathurin, additional, N’Djetchi, Martial Kassi, additional, Kaba, Dramane, additional, Kaboré, Jacques, additional, Ilboudo, Hamidou, additional, Ahouty, Bernadin Ahouty, additional, Koné, Minayégninrin, additional, Coulibaly, Bamoro, additional, Konan, Thomas, additional, Segard, Adeline, additional, Kouakou, Lingué, additional, De Meeûs, Thierry, additional, Ravel, Sophie, additional, Solano, Philippe, additional, Bart, Jean-Mathieu, additional, and Jamonneau, Vincent, additional

Published
2021
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30. Passive surveillance of human African trypanosomiasis in Côte d’Ivoire: Understanding prevalence, clinical symptoms and signs, and diagnostic test characteristics

Author

Koné, Minayégninrin, primary, Kaba, Dramane, additional, Kaboré, Jacques, additional, Thomas, Lian Francesca, additional, Falzon, Laura Cristina, additional, Koffi, Mathurin, additional, Kouamé, Cyrille Mambo, additional, Ahouty, Bernardin, additional, Compaoré, Charlie Franck Alfred, additional, N’Gouan, Emmanuel Kouassi, additional, Solano, Philippe, additional, Fèvre, Eric, additional, Büscher, Philippe, additional, Lejon, Veerle, additional, and Jamonneau, Vincent, additional

Published
2021
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31. Use of vector control to protect people from sleeping sickness in the focus of Bonon (Côte d’Ivoire)

Author

Kaba, Dramane, primary, Djohan, Vincent, additional, Berté, Djakaridja, additional, TA, Bi Tra Dieudonné, additional, Selby, Richard, additional, Kouadio, Koffi Alain De Marie, additional, Coulibaly, Bamoro, additional, Traoré, Gabehonron, additional, Rayaisse, Jean-Baptiste, additional, Fauret, Pierre, additional, Jamonneau, Vincent, additional, Lingue, Kouakou, additional, Solano, Phillipe, additional, Torr, Steve J., additional, and Courtin, Fabrice, additional

Published
2021
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32. The complex health seeking pathway of a human African trypanosomiasis patient in Côte d’Ivoire underlines the need of setting up passive surveillance systems

Author

Koné, Minayégninrin, N’Gouan, Emmanuel Kouassi, Kaba, Dramane, Koffi, Mathurin, Kouakou, Lingué, N’Dri, Louis, Kouamé, Cyrille Mambo, Nanan, Valentin Kouassi, Tapé, Gossé Apollinaire, Coulibaly, Bamoro, Courtin, Fabrice, Ahouty, Bernardin, Djohan, Vincent, Bucheton, Bruno, Solano, Philippe, Büscher, Philippe, Lejon, Veerle, and Jamonneau, Vincent

Subjects
Trypanosoma, Delayed Diagnosis, Physiology, Epidemiology, Trypanosoma brucei gambiense, RC955-962, Fevers, African Trypanosomiasis, Chronic Disease Indicators, Medical Conditions, Signs and Symptoms, Trypanosomiasis, Diagnostic Medicine, Arctic medicine. Tropical medicine, Zoonoses, Medicine and Health Sciences, Parasitic Diseases, Humans, Public and Occupational Health, Child, Cerebrospinal Fluid, Protozoans, Protozoan Infections, Organisms, Biology and Life Sciences, Eukaryota, Neglected Diseases, Tropical Diseases, Parasitic Protozoans, Body Fluids, Patient Care Management, Infectious Diseases, Blood, Cote d'Ivoire, Trypanosomiasis, African, Medical Risk Factors, Parasitology, Female, Public aspects of medicine, RA1-1270, Anatomy, Clinical Medicine, Research Article, Neglected Tropical Diseases
Abstract

Background Significant efforts to control human African trypanosomiasis (HAT) over the two past decades have resulted in drastic decrease of its prevalence in Côte d’Ivoire. In this context, passive surveillance, integrated in the national health system and based on clinical suspicion, was reinforced. We describe here the health-seeking pathway of a girl who was the first HAT patient diagnosed through this strategy in August 2017. Methods After definitive diagnosis of this patient, epidemiological investigations were carried out into the clinical evolution and the health and therapeutic itinerary of the patient before diagnosis. Results At the time of diagnosis, the patient was positive in both serological and molecular tests and trypanosomes were detected in blood and cerebrospinal fluid. She suffered from important neurological disorders. The first disease symptoms had appeared three years earlier, and the patient had visited several public and private peripheral health care centres and hospitals in different cities. The failure to diagnose HAT for such a long time caused significant health deterioration and was an important financial burden for the family. Conclusion This description illustrates the complexity of detecting the last HAT cases due to complex diagnosis and the progressive disinterest and unawareness by both health professionals and the population. It confirms the need of implementing passive surveillance in combination with continued sensitization and health staff training., Author summary Human African trypanosomiasis (HAT) or sleeping sickness is a parasitic disease caused by Trypanosoma brucei that is transmitted by tsetse flies. In 2012, HAT was included in the World Health Organization roadmap for the control of neglected tropical diseases with the objective of elimination as a public health problem by 2020. In Côte d’Ivoire, HAT prevalence has dropped sharply the last decade. A passive HAT surveillance was therefore integrated in the national health system, which allowed to detect a first patient in 2017. This article describes the complex health seeking pathway and suffering before diagnosis of this patient, an 11 years old girl, and illustrates the challenge when health agents and population no longer consider HAT as a threat in an elimination context. Our results show the need to install a solid surveillance system, in combination with continued sensitization and repeated health staff training.

Published
2020

33. Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies

Author

Ndung’u, Joseph Mathu, primary, Boulangé, Alain, additional, Picado, Albert, additional, Mugenyi, Albert, additional, Mortensen, Allan, additional, Hope, Andrew, additional, Mollo, Brahim Guihini, additional, Bucheton, Bruno, additional, Wamboga, Charles, additional, Waiswa, Charles, additional, Kaba, Dramane, additional, Matovu, Enock, additional, Courtin, Fabrice, additional, Garrod, Gala, additional, Gimonneau, Geoffrey, additional, Bingham, Georgina V., additional, Hassane, Hassane Mahamat, additional, Tirados, Inaki, additional, Saldanha, Isabel, additional, Kabore, Jacques, additional, Rayaisse, Jean-Baptiste, additional, Bart, Jean-Mathieu, additional, Lingley, Jessica, additional, Esterhuizen, Johan, additional, Longbottom, Joshua, additional, Pulford, Justin, additional, Kouakou, Lingue, additional, Sanogo, Lassina, additional, Cunningham, Lucas, additional, Camara, Mamadou, additional, Koffi, Mathurin, additional, Stanton, Michelle, additional, Lehane, Mike, additional, Kagbadouno, Moise Saa, additional, Camara, Oumou, additional, Bessell, Paul, additional, Mallaye, Peka, additional, Solano, Philippe, additional, Selby, Richard, additional, Dunkley, Sophie, additional, Torr, Steve, additional, Biéler, Sylvain, additional, Lejon, Veerle, additional, Jamonneau, Vincent, additional, Yoni, Wilfried, additional, and Katz, Zachary, additional

Published
2020
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34. PS-003: EVIDENCE-INFORMED POLICY MAKING: CHALLENGES AND OPPORTUNITIES

Author

Makanga, Michael, Beattie, Pauline, Breugelmans, Gabrielle, Nyirenda, Thomas, Bockarie, Moses, Tanner, Marcel, Volmink, Jimmy, Hankins, Catherine, Walzl, Gerhard, Chegou, Novel, Malherbe, Stephanus, Hatherill, Mark, Scriba, Thomas J., Zak, Daniel E., Barry, Clifton E., Kaufmann, Stefan H.E., Noor, Abdisalan, Strub-Wourgaft, Nathalie, Phillips, Patrick, Munguambe, Khátia, Ravinetto, Raffaella, Tinto, Halidou, Diro, Ermias, Mahendrahata, Yodi, Okebe, Joseph, Rijal, Suman, Garcia, Coralith, Sundar, Shyam, Ndayisaba, Gilles, Sopheak, Thai, Ngoduc, Thang, Loen, Harry Van, Jacobs, Jan, D'Alessandro, Umberto, Boelaert, Marleen, Buvé, Anne, Kamalo, Patrick, Manda-Taylor, Lucinda, Rennie, Stuart, Mokgatla, Boitumelo, Bahati, Prince, Ijsselmuiden, Carel, Afolabi, Muhammed, Mcgrath, Nuala, Kampmann, Beate, Imoukhuede, Egeruan, Alexander, Neal, Larson, Heidi, Chandramohan, Daniel, Bojang, Kalifa, Kasaro, Margaret Phiri, Muluka, Brenda, Kaunda, Kaunda, Morse, Jill, Westfall, Andrew, Kapata, Nathan, Kruuner, Annika, Henostroza, German, Reid, Stewart, Alabi, Abraham, Foguim, Francis, Sankarganesh, Jeyaraj, Bruske, Ellen, Mfoumbi, Arnault, Mevyann, Chester, Adegnika, Ayola, Lell, Bertrand, Kranzer, Katharina, Kremsner, Peter, Grobusch, Martin, Sabiiti, Wilber, Ntinginya, Nyanda, Kuchaka, Davis, Azam, Khalide, Kampira, Elizabeth, Mtafya, Bariki, Bowness, Ruth, Bhatt, Nilesh, Davies, Gerry, Kibiki, Gibson, Gillespie, Stephen, Lejon, Veerle, Ilboudo, Hamidou, Mumba, Dieudonné, Camara, Mamady, Kaba, Dramane, Lumbala, Crispin, Fèvre, Eric, Jamonneau, Vincent, Bucheton, Bruno, Büscher, Philippe, Chisenga, Caroline, Sinkala, Edford, Chilengi, Roma, Chitundu, Hellen, Zyambo, Zude, Wandeler, Gilles, Vinikoor, Michael, Emilie, Dama, Camara, Oumou, Mathurin, Koffi, Guiguigbaza-Kossigan, Dayo, Philippe, Büscher, Regassa, Fikru, Hassane, Sakande, Bienvenu, Somda Martin, Fabrice, Courtin, Ouédraogo, Elie, Kouakou, Lingue, Owusu, Michael, Mensah, Eric, Enimil, Anthony, Mutocheluh, Mohamed, Ndongo, Francis Ateba, Tejiokem, Mathurin Cyrille, Texier, Gaetan, Penda, Calixte, Ndiang, Suzie, Ndongo, Jean-Audrey, Guemkam, Georgette, Sofeu, Casimir Ledoux, Afumbom, Kfutwa, Faye, Albert, Msellati, Philippe, Warszawski, Josiane, Vos, Alinda, Devillé, Walter, Barth, Roos, Klipstein-Grobusch, Kerstin, Tempelman, Hugo, Venter, François, Coutinho, Roel, Grobbee, Diederick, Ssemwanga, Deogratius, Lyagoba, Frederick, Magambo, Brian, Kapaata, Anne, Kirangwa, Joseph, Nannyonjo, Maria, Nassolo, Faridah, Nsubuga, Rebecca, Yebra, Gonzalo, Brown, Andrew, Kaleebu, Pontiano, Nylén, Hanna, Habtewold, Abiy, Makonnen, Eyasu, Yimer, Getnet, Burhenne, Jürgen, Diczfalusy, Ulf, Aklillu, Eleni, Steele, Duncan, Walker, Richard, Simuyandi, Michelo, Beres, Laura, Bosomprah, Samuel, Ansumana, Rashid, Taitt, C., Lamin, J.M., Jacobsen, K.H., Mulvaney, S.P., Leski, T., Bangura, U., Stenger, D., Vries, Sophie De, Zinsou, Frejus Jeannot, Honkpehedji, J, Dejon, Jean Claude, Loembe, Marguerite Massinga, Bache, Bache, Pakker, Nadine, Leeuwen, Remko Van, Hounkpatin, Aurore Bouyoukou, Yazdanbakhsh, Maria, Bethony, Jeffrey, Hotez, Peter, Diemert, David, Bache, Bache Emmanuel, Fernandes, José F., Mba, Régis M Obiang, Kabwende, Anita L., Grobusch, Martin P., Krishna, Sanjeev, Kremsner, Peter G., Todagbe, Agnandji Selidji, Nambozi, Michael, Kabuya, Jean-Bertin, Hachizovu, Sebastian, Mwakazanga, David, Kasongo, Webster, Buyze, Jozefien, Mulenga, Modest, Geertruyden, Jean-Pierre, Gitaka, Jesse, Chan, Chim, Kongere, James, Kagaya, Wataru, Kaneko, Akira, Kabore, Naomie, Barry, Nouhoun, Kabre, Zachari, Werme, Karidia, Fofana, Aminata, Compaore, Daniel, Nikiema, Frederic, Some, Fabrice, Djimde, Abdoulaye, Zongo, Issaka, Ouedraogo, Bosco, Kone, Aminatou, Sagara, Issaka, Björkman, Anders, Gil, Jose Pedro, Nchinda, Godwin, Bopda, Alain, Nji, Nadesh, Ambada, Georgia, Ngu, Loveline, Tchadji, Jules, Sake, Carol, Magagoum, Suzanne, Njambe, Ghislain D., Lisom, Abel, Park, Chae Gyu, Tait, Dereck, Sibusiso, Hlatjwako, Manda, Olga, Croucher, Kristin, Westhuizen, Anja Van Der, Mshanga, Isaac, Levin, Jonathan, Nanvubya, Annet, Kibengo, Freddie, Jaoko, Walter, Pala, Pietro, Perreau, Matthieu, Namuniina, Annemarie, Kitandwe, Paul, Tapia, Gonzalo, Serwanga, Jennifer, Yates, Nicole, Fast, Pat, Mayer, Bryan, Montefiori, David, Tomaras, Georgia, Robb, Merlin, Lee, Carter, Wagner, Ralf, Sanders, Edward, Kilembe, William, Kiwanuka, Noah, Gilmour, Jill, Kuipers, Hester, Vooij, Dani, Chinyenze, Kundai, Priddy, Frances, Ding, Song, Hanke, Tom, Pantaleo, Giuseppe, Ngasala, Billy, Jovel, Irina, Malmberg, Maja, Mmbando, Bruno, Premji, Zul, Mårtensson, Andreas, Mwaiswelo, Richard, Agbor, Lenshina, Apinjoh, Tobias, Mwanza, Sydney, Chileshe, Justin, Joshi, Sudhaunshu, Malunga, Phidelis, Manyando, Christine, Laufer, Miriam, Dara, Antoine, Niangaly, Amadou, Sinha, Indranil, Brodin, David, Fofana, Bakary, Dama, Souleymane, Dembele, Demba, Sidibe, Bakary, Diallo, Nouhoum, Thera, Mahamadou, Wright, Karin, Gil, Jose, Doumbo, Ogobara, Baraka, Vito, Nabasumba, Carolyn, Francis, Filbert, Lutumba, Pascal, Mavoko, Hypolite, Alifrangis, Michael, Geertruyden, Jean-Pierre Van, Sissoko, Sekou, Sangaré, Cheick, Toure, Sekou, Sanogo, Kassim, Diakite, Hamadoun, Toure, Siaka, Doumbia, Diagassan, Haidara, Kadiatou, Julé, Amélie, Ashurst, Hazel, Merson, Laura, Olliaro, Piero, Marsh, Vicki, Lang, Trudie, Guérin, Philippe, Awuondo, Kennedy, Njenga, Daniel, Nyakarungu, Elizabeth, Titus, Pauline, Sutamihardja, Awalludin, Lowe, Brett, Ogutu, Bernhards, Billingsley, Peter, Soulama, Issiaka, Kaboré, Moïse, Coulibaly, Aboubacar, Ouattara, Maurice, Sanon, Souleymane, Diarra, Amidou, Bougouma, Edith, Ouedraogo, Alphonse, Sombie, Benjamin, Ouedraogo, Amidou, Kargougou, Désiré, Ouattara, Daouda, Issa, Nebie, Tiono, Alfred, Sirima, Sodiomon, Chaponda, Mike, Dabira, Edgard, Dao, François, Dara, Nianwalou, Sidibe, Bouran, Coulibaly, Moctar, Tolo, Allaye, Maiga, Hamma, Ouologuem, Nouhoum, Niangaly, Hamidou, Botchway, Felix, Wilson, Nana, Dickinson-Copeland, Carmen M, Adjei, Andrew A., Wilson, Michael, Stiles, Jonathan K., Hamid, Muzamil Abdel, Awad-Elgeid, Mona, Nasr, Awad, Netongo, Palmer, Kamdem, Séverin, Velavan, Thirumalaisamy, Lasry, Estrella, Diarra, Modibo, Bamadio, Amadou, Traore, Aliou, Coumare, Samba, Soma, Bahonan, Dicko, Yeyia, Sangare, Boubou, Tembely, Aly, Traore, Djibril, Haidara, Aboubecrin, Dicko, Alassane, Diawara, Elisabeth, Beavogui, Abdoul, Camara, Daouda, Sylla, Malick, Yattara, Mohamed, Sow, Amadou, Camara, Gnèpou Camara, Diallo, Saliou, Mombo-Ngoma, Ghyslain, Remppis, Jonathan, Sievers, Moritz, Manego, Rella Zoleko, Endamne, Lilian, Hutchinson, David, Held, Jana, Supan, Christian, Salazar, Carmen L. Ospina, Bonkian, Léa Nadège, Nahum, Alain, Sié, Ali, Abdulla, Salim, Cantalloube, Cathy, Djeriou, Elhadj, Bouyou-Akotet, Marielle, Mordmüller, Benjamin, Siribie, Mohamadou, Sirima, Sodiomon B., Ouattara, San Maurice, Coulibaly, Sam, Kabore, Jean Moïse, Amidou, Diarra, Tekete, Mamadou, Burhenne, Juergen, Traore, Oumar, Haefeli, Walter, Borrmann, Steffen, Kaboré, Naomie, Kabré, Zachari, Nikèma, Fréderic, Compaoré, Daniel, Somé, Fabrice, Djimdé, Abdoulaye, Ouédraogo, Jean, Chalwe, Victor, Miller, John, Diakité, Hamadoun, Greco, Beatrice, Spangenberg, Thomas, Kourany-Lefoll, Elly, Oeuvray, Claude, Mulry, Jim, Tyagarajan, Kamala, Magsaam, Bettina, Barnes, Karen, Hodel, Eva Maria, Humphreys, Georgina, Pace, Cheryl, Banda, C.G, Denti, Paulo, Allen, Elizabeth, Lalloo, David, Mwapasa, Victor, Terlouw, Anja, Mwesigwa, Julia, Achan, Jane, Jawara, Musa, Ditanna, Gian, Worwui, Archibald, Affara, Muna, Koukouikila-Koussounda, Félix, Kombo, Michael, Vouvoungui, Christevy, Ntoumi, Francine, Etoka-Beka, Mandingha Kosso, Deibert, Julia, Poulain, Pierre, Kobawila, Simon, Gueye, Nerly Gampio, Koukouikila-Koussounda, Felix, Seda, Brian, Kwambai, Titus, Jangu, Phelix, Samuels, Aaron, ter Kuile, Feike, Kariuki, Simon, Barry, Aissata, Bousema, Teun, Okech, Brenda, Egwang, Thomas, Corran, Patrick, Riley, Eleanor, Ezennia, Ifeoma, Ekwunife, Obinna, Muleba, Mbanga, Stevenson, Jennifer, Mbata, Keith, Coetzee, Maureen, Norris, Douglas, Moneke-Anyanwoke, Ngozi, Momodou, Jasseh, Clarke, Ed, Scott, Susana, Tijani, Adelani, Djimde, Moussa, Vaillant, Michel, Samouda, Hanen, Mensah, Victorine, Roetynck, Sophie, Kanteh, Ebrima, Bowyer, Georgina, Ndaw, Amy, Oko, Francis, Bliss, Carly, Jagne, Ya Jankey, Cortese, Riccardo, Nicosia, Alfredo, Roberts, Rachel, D'Alessio, Flavia, Leroy, Odile, Faye, Babacar, Cisse, Badara, Gerry, Stephen, Viebig, Nicola, Lawrie, Alison, Ewer, Katie, Hill, Adrian, Nebie, Issa, Tiono, Alfred B, Sanou, Guillaume, Konate, Amadou T, Yaro, Baptiste J, Sodiomon, Sirima, Honkpehedji, Yabo, Agobe, Jean Claude Dejon, Zinsou, Frejus, Mengue, Juliana, Richie, Thomas, Hoffman, Stephen, Nouatin, Odilon, Ngoa, Ulysse Ateba, Edoa, Jean R, Homoet, Andreas, Engelhon, Julie Englhon, Massinga-Louembe, Marguerite, Esen, Meral, Theisen, Michael, Sim, Kim Lee, Luty, Adrian Jf, Moutairou, Kabirou, Dinko, Bismarck, King, Elizabeth, Targett, Geoffrey, Sutherland, Colin, Likhovole, Clement, Ouma, Collins, Vulule, John, Musau, Susan, Khayumbi, Jeremiah, Okumu, Albert, Murithi, Wilfred, Otu, Jacob, Gehre, Florian, Zingue, Dezemon, Kudzawu, Samuel, Forson, Audrey, Mane, Morto, Rabna, Paulo, Diarra, Bassirou, Kayede, Salako, Adebiyi, Emmanuel, Kehinde, Aderemi, Onyejepu, Nneka, Onubogu, Catherine, Idigbe, Emmanuel, Ba, Awa, Diallo, Aissatou, Mboup, Souleymane, Disse, Kodjo, Kadanga, Gerard, Dagnra, Yaotse, Baldeh, Ignatius, Corrah, Tumani, Jong, Bouke De, Antonio, Martin, Musanabaganwa, Clarisse, Musabyimana, Jean Pierre, Karita, Etienne, Diop, Blondin, Nambajimana, Abidan, Dushimiyimana, Valentine, Karame, Prosper, Russell, Jim, Ndoli, Jules, Hategekimana, Theobald, Sendegeya, Augustin, Condo, Jeannine, Binagwaho, Agnes, Okonko, Iheanyi, Okerentugba, Phillip, Opaleye, Oluyinka, Awujo, Ezinwanne, Frank-Peterside, Nnenna, Moyo, Sikhulile, Kotokwe, Kenanao, Mohammed, Terence, Boleo, Coretah, Mupfumi, Lucy, Chishala, Samuel, Gaseitsiwe, Simani, Tsalaile, Lesedi, Bussmann, Herman, Makhema, Joseph, Baum, Marianna, Marlink, Richard, Engelbretch, Susan, Essex, Max, Novitsky, Vladimir, Saka, Emmanuel, Kalipalire, Zex, Bhairavabhotla, Ravikiran, Midiani, Dalitso, Sherman, Judith, Mgode, Georgies, Cox, Christophe, Bwana, Dickens, Mtui, Leah, Magesa, Daniel, Kahwa, Amos, Mfinanga, Godfrey, Mulder, Christiaan, Borain, Nick, Petersen, Lizette, Plessis, Julianne Du, Theron, Grant, Holm-Hansen, Carol, Tekwu, Emmanuel Mouafo, Sidze, Larissa Kamgue, Assam, Jean Paul Assam, Eyangoh, Sarah, Niemann, Stefan, Beng, Veronique Penlap, Frank, Matthias, Atiadeve, Samuel, Hilmann, Doris, Awoniyi, Dolapo, Baumann, Ralf, Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre, Kaempfer, Susanne, Singh, Mahavir, Mwanza, Winnie, Milimo, Deborah, Moyo, Maureen, Kasese, Nkatya, Cheeba-Lengwe, Maina, Munkondya, Stembiso, Ayles, Helen, Haas, Petra De, Muyoyeta, Monde, Namuganga, Anna Ritah, Kizza, Harriet Mayanja, Mendy, Alieu, Tientcheu, Leopold, Ayorinde, Abigail, Coker, Edward, Egere, Uzochukwu, Coussens, Anna, Naude, Celeste, Chaplin, George, Noursadeghi, Mahdad, Martineau, Adrian, Jablonski, Nina, Wilkinson, Robert, Ouedraogo, Henri Gautier, Matteelli, Alberto, Regazzi, Mario, Tarnagda, Grissoum, Villani, Paola, Sulis, Giorgia, Diagbouga, Serge, Roggi, Alberto, Giorgetti, Francesco, Kouanda, Seni, Bidias, Amel, Ndjonka, Dieudonné, Olemba, Clémence, Souleymanou, Arabo, Mukonzo, Jackson, Kuteesa, Ronald, Ogwal-Okeng, Jasper, Gustafsson, Lars L., Owen, Joel, Bassi, Peter, Gashau, Wadzani, Olaf, Klungel, Dodoo, Alexander, Okonkwo, Prosper, Kanki, Phyllis, Maruapula, Dorcas, Seraise, Boitumelo, Einkauf, Kevin, Reilly, Amanda, Rowley, Christopher, Musonda, Rosemary, Framhein, Anna, Mpagama, Stella, Semvua, Hadija, Maboko, Leonard, Hoelscher, Michael, Heinrich, Norbert, Mulenga, Lloyd, Kaayunga, Callistus, Davies, Mary-Ann, Egger, Matthias, Musukuma, Kalo, Dambe, Rosalia, Usadi, Benjamin, Ngari, Moses, Thitiri, Johnstone, Mwalekwa, Laura, Fegan, Greg, Berkley, James, Nsagha, Dickson, Munamunungu, Virginia, Bolton, Carolyn, Siyunda, Alice, Shilimi, Jacinta, Bucciardini, Raffaella, Fragola, Vincenzo, Abegaz, Teshome, Lucattini, Stefano, Halifom, Atakilt, Tadesse, Eskedar, Berhe, Micheal, Pugliese, Katherina, Castro, Paola De, Terlizzi, Roberta, Fucili, Luca, Gregorio, Massimiliano Di, Mirra, Marco, Zegeye, Teame, Binelli, Andrea, Vella, Stefano, Abraham, Loko, Godefay, Hagos, Rakotoarivelo, Rivo, Raberahona, Mihaja, Randriamampionona, Njary, Andriamihaja, Rabezanahary, Rasamoelina, Tahinamandranto, Cornet, Muriel, Randria, Mamy Jean De Dieu, Benet, Thomas, Vanhems, Philippe, Andrianarivelo, Mala Rakoto, Chirwa, Uchizi, Michelo, Charles, Hamoonga, Raymond, Wandiga, Steve, Oduor, Patience, Agaya, Janet, Sharma, Aditya, Cavanaugh, Sean, Cain, Kevin, Mukisa, John, Mupere, Ezekiel, Worodria, William, Ngom, Justice Trésor, Koro, Francioli, Godwe, Celestin, Adande, Clemence, Ateugieu, Romaric, Onana, Tatiana, Ngono, Annie, Kamdem, Yannick, Ngo-Niobe, Sara, Etoa, François-Xavier, Kanengoni, Muchineripi, Ruzario, Sithembile, Ndebele, Paul, Shana, Melody, Tarumbiswa, Fadzai, Musesengwa, Rosemary, Gutsire, Rutendo, Fisher, Kevin, Thyagarajan, Bargavi, Akanbi, Olusola, Binuyo, Michael, Ssengooba, Willy, Respeito, Durval, Mambuque, Edson, Blanco, Silvia, Mandomando, Inacio, Cobelens, Frank, Garcia-Basteiro, Alberto, Tamene, Ayele, Topp, Stephanie, Mwamba, Chanda, Padian, Nancy, Sikazwe, Izukanji, Geng, Elvin, Holmes, Charles, Sikombe, Kombatende, Hantuba, Cardinal, Czaicki, Nancy, Simbeza, Sandra, Somwe, Paul, Umulisa, Michele, Ilo, Jennifer, Kestelyn, Evelyne, Uwineza, Mireille, Agaba, Stephen, Delvaux, Therese, Wijgert, Janneke, Gethi, Dickson, Odeny, Lazarus, Tamandjou, Cynthia, Kaindjee-Tjituka, Francina, Brandt, Laura, Cotton, Mark, Nel, Etienne, Preiser, Wolfgang, Andersson, Monique, Adepoju, Abiola, Magana, Musa, Etsetowaghan, Andrew, Chilikwazi, Mutinta, Sutcliffe, Catherine, Thuma, Philip, Sinywimaanzi, Kathy, Matakala, Hellen, Munachoonga, Passwell, Moss, William, Masenza, Issa Sabi, Geisenberger, Otto, Agrea, Peter, Rwegoshora, France, Mahiga, Hellen, Olomi, Willyhelmina, Kroidl, Arne, Kayode, Gbenga, Amoakoh-Coleman, Mary, Ansah, Evelyn, Uthman, Olalekan, Fokam, Joseph, Santoro, Maria-Mercedes, Musolo, Chrissie, Chimbiri, Isabel, Chikwenga, Gloria, Deula, Ruth, Massari, Riccardo, Lungu, Agness, Perno, Carlo-Federico, Ndzengue, Georgia, Loveline, Ngu, Lissom, Abel, Flaurent, Tchouangueu, Sosso, Samuel, Essomba, Claudine, Kpeli, Grace, Otchere, Isaac, Lamelas, Araceli, Buultjens, Andrew, Bulach, Dieter, Baines, Sarah, Seemann, Torsten, Giulieri, Stefano, Nakobu, Zuliehatu, Aboagye, Samuel, Owusu-Mireku, Evelyn, Danso, Emelia, Hauser, Julia, Hinic, Vladimira, Pluschke, Gerd, Stinear, Timothy, Yeboah-Manu, Dorothy, Elshayeb, Ayman, Siddig, Marmar El, Ahmed, Abdel Azim, Hussien, Adil El, Kabwe, Mwila, Tembo, John, Chilukutu, Lophina, Chilufya, Moses, Ngulube, Francis, Lukwesa, Chileshe, Enne, Virve, Wexner, Hannah, Mwananyanda, Lawrence, Hamer, Davidson, Sinyangwe, Sylvester, Ahmed, Yusuf, Klein, Nigel, Maeurer, Markus, Zumla, Ali, Bates, Matthew, Beyala, Landry, Etienne, Guenou, Anthony, Njimbia, Benjamin, Azike, Ateudjieu, Jerome, Chibwe, Bertha, Ojok, David, Tarr, Christine Attia, Perez, Guillermo Martinez, Omeonga, Senga, Kibungu, Fanta, Meyer, Ana, Lansana, Peter, Mayor, Alfredo, Onyango, Peter, Loggerenberg, François Van, Furtado, Tamzin, Boggs, Liam, Segrt, Alexis, Dochez, Carine, Burnett, Rosemary, Mphahlele, M. Jeffrey, Miiro, George, Mbidde, Edward, Peshu, Norbert, Kivaya, Esther, Ngowi, Bernard, Kavishe, Reginald, Maowia, Mukhtar, Sandstrom, Eric, Ayuo, Elizabeth, Mmbaga, Blandina, Leisegang, Cordelia, Thorpe, Marie, Batchilly, Elizabeth, N'Guessan, Jean-Pierre, Kanteh, Dembo, Søfteland, Solrun, Sebitloane, Motshedisi, Vwalika, Bellington, Taylor, Myra, Galappaththi-Arachchige, Hashini, Holmen, Sigve, Gundersen, Svein Gunnar, Ndhlovu, Patricia, Kjetland, Eyrun Floerecke, Kombe, Francis, Toohey, Jacintha, Pienaar, Elizabeth, Kredo, Tamara, Cham, Pa Modou, Abubakar, Ismaela, Dondeh, Bai Lamin, Vischer, Nerina, Pfeiffer, Constanze, Burri, Christian, Musukwa, Kalo, Zürcher, Samuel, Mwandu, Temwani, Bauer, Sophie, Adriko, Moses, Mwaura, Peter, Omolloh, Kevin, Jones, Clarer, Malecela, Mwelecele, Hamidu, Buhari Adamu, Jenner, Tettevi Edward, Asiedu, Larbi John, Osei-Atweneboana, Mike, Afeke, Innocent, Addo, Phyllis, Newman, Mercy, Durnez, Lies, Eddyani, Miriam, Ammisah, Nana, Abas, Mona, Quartey, Maxwell, Ablordey, Anthony, Akinwale, Olaoluwa, Adeneye, Adeniyi, Ezeugwu, Sylvanus, Olukosi, Yetunde, Adewale, Babatunde, Sulyman, Medinat, Mafe, Margaret, Okwuzu, Jane, Gyang, Pam, Nwafor, Timothy, Henry, Uzoma, Musa, Bilkisu, Ujah, Innocent, Agobé, Jean Claude Dejon, Grau-Pujol, Berta, Sacoor, Charfudin, Nhabomba, Augusto, Casellas, Aina, Quintó, Llorenç, Subirà, Carme, Giné, Ricard, Valentín, Antònia, Muñoz, Jose, Nikiema, Marguerite, Ky-Ba, Absatou, Comapore, Kiswendsida Abdou Muller, Traore, Alfred, Sangare, Lassana, Oluremi, Adeolu, Michel, Mandro, Camara, Yaya, Sanneh, Bakary, Cuamba, Inocencia, Gutiérrez, Jose, Lázaro, Carlota, Mejia, Rojelio, Adedeji, Abimbola, Folorunsho, Sola, Demehin, Pelumi, Akinsanya, Bamidele, Cowley, Giovanna, Silva, Eunice Teixeira Da, Nabicassa, Meno, Barros, Pedrozinho Duarte Pereira De, Blif, Milena Mbote, Bailey, Robin, Last, Anna, Mahendradhata, Yodi, Gotuzzo, Eduardo, Nys, Kateljine De, Casteels, Minnes, Nona, Sylvie Kwedi, Lumeka, Kabwende, Todagbe, Agnandji, Djima, Mariam Mama, Ukpong, Morenike, Sagay, Atiene, Khamofu, Hadiza, Torpey, Kwasi, Afiadigwe, Evaristus, Anenih, James, Ezechi, Oliver, Nweneka, Chidi, Idoko, John, Muhumuza, Simon, Katahoire, Anne, Nuwaha, Fred, Olsen, Annette, Okeyo, Seth, Omollo, Raymond, Kimutai, Robert, Ochieng, Michael, Egondi, Thaddaeus, Moonga, Clement, Chileshe, Chisele, Magwende, George, Anumudu, Chiaka, Onile, Olugbenga, Oladele, Victoria, Adebayo, Adewale, Awobode, Henrietta, Oyeyemi, Oyetunde, Odaibo, Alexander, Kabuye, Emily, Lutalo, Tom, Njua-Yafi, Clarisse, Nkuo-Akenji, Theresa, Anchang-Kimbi, Judith, Mugri, Regina, Chi, Hanesh, Tata, Rolland, Njumkeng, Charles, Dodoo, Daniel, Achidi, Eric, Fernandes, José, Bache, Emmanuel B., Matakala, Kalumbu, Searle, Kelly, Greenman, Michelle, and Rainwater-Lovett, Kaitlin

Subjects
Abstracts of Poster Presentations, Abstracts of Oral Presentations, Author Index, Abstracts of Presentations in Plenary Sessions, Article, Abstracts of the Eighth Edctp Forum, 6–9 November 2016
Published
2017

35. Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with 'screen, diagnose and treat' using innovative tools and strategies

Author

Ndung'u, Joseph Mathu, Boulangé, Alain, Picado, Albert, Mugenyi, Albert, Mortensen, Allan, Hope, Andrew, Guihini Mollo, Brahim, Bucheton, Bruno, Wamboga, Charles, Waiswa, Charles, Kaba, Dramane, Matovu, Enock, Courtin, Fabrice, Garrod, Gala, Gimonneau, Geoffrey, Bingham, Georgina V., Mahamat Hassane, Hassane, Tirados, Inaki, Saldanha, Isabel, Kaboré, Jacques, et al., Ndung'u, Joseph Mathu, Boulangé, Alain, Picado, Albert, Mugenyi, Albert, Mortensen, Allan, Hope, Andrew, Guihini Mollo, Brahim, Bucheton, Bruno, Wamboga, Charles, Waiswa, Charles, Kaba, Dramane, Matovu, Enock, Courtin, Fabrice, Garrod, Gala, Gimonneau, Geoffrey, Bingham, Georgina V., Mahamat Hassane, Hassane, Tirados, Inaki, Saldanha, Isabel, Kaboré, Jacques, and et al.

Published
2020

36. PO 8441 EXPERIMENTAL COMPARISON OF SENSITIVITY OF LAMP AND REAL-TIME PCR

Author

Kaboré, Jacques, primary, Ilboudo, Hamidou, additional, Compaoré, Charlie FA, additional, Camara, Oumou, additional, Bamba, Mohamed, additional, Sakandé, Hassane, additional, Camara, Mamadou, additional, Bucheton, Bruno, additional, Kaba, Dramane, additional, Jamonneau, Vincent, additional, Deborggraeve, Stijn, additional, and Lejon, Veerle, additional

Published
2019
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37. Evaluation de la toxicité de pesticides sur les glossines

Author

Yameogo, J., Kaba, Dramane, Rayaissé, Jean-Baptiste, Solano, Philippe, Courtin, Fabrice, and Gimonneau, Geoffrey

Abstract

En Afrique subsaharienne, la Trypanosomiase Humaine Africaine (THA ou maladie du sommeil) est une maladie parasitaire négligée provoquée par un trypanosome (protozoaire flagellé), transmis à l'homme par la mouche tsé-tsé (Glossina spp.). Cette mouche hématophage est également en grande partie responsable de la transmission de trypanosomes aux animaux, provoquant la Trypanosomose Animale Africaine (TAA ou nagana). Ce complexe de maladies a un impact important sur la santé humaine et animale et sur la productivité en Afrique. L'élevage du bétail dans les zones endémiques est difficile, et entraîne des pertes économiques de plusieurs milliards de dollars par an. La mouche tsé-tsé reste cependant un insecte vulnérable, sensible aux modifications environnementales et aux insecticides. En 2015 en Côte d'Ivoire, il a été mis en évidence une grande zone forestière (200 km2) où les glossines (Glossina palpalis palpalis) ont totalement disparues, en l'absence de lutte anti-vectorielle bien que l'environnement semble rester propice à leur développement. L'hypothèse sous-jacente à la disparition des glossines serait liée aux fortes densités de population humaines et aux pratiques agricoles associées qui se caractérisent par une utilisation importante de de produits phytosanitaires et qui affecteraient la survie des mouches. Après avoir caractérisé les produits les plus utilisés par les agriculteurs, nous les avons testés en bioessays par contact tarsal sur l'espèce Glossina palpalis gambiensis. Cette étude actuellement en cours nous permettra de mettre en évidence l'impact collatéral des traitements phytosanitaires en forêt de Côte d'Ivoire sur les populations de glossines.

Published
2018

38. Approche one health pour une élimination durable de la trypanosomiase humaine Africaine dans le foyer de THA de Sinfra en Côte d'Ivoire

Author

Kaba, Dramane, Gimonneau, Geoffrey, Courtin, Fabrice, Djohan, Vincent, Berté, Djakaridja, Ta Bi Tra, Dieudonné, Kouadio, Koffi Alain Demarie, Rayaissé, Jean-Baptiste, Kouakou, Lingué, N'Gouan Kouassi, Emmanuel, Jamonneau, Vincent, Solano, Philippe, and Koffi, Mathurin

Abstract

Introduction : Les trypanosomoses africaines sont transmises par la mouche tsé-tsé aux humains et au bétail. En Côte d'Ivoire, la Trypanosomiase Humaine Africaine (THA) sévit principalement dans la région de la Marahoué, sous forme de foyers où sévit également la Trypanosomose Animale Africaine (TAA). Cependant, le réservoir animal à T.b.gambiense, qui intervient probablement dans le cycle pathogène de la maladie chez l'homme, n'a jamais été pris en compte dans la lutte contre la THA en Côte d'Ivoire. Matériel et méthodes : Dans le but de mener une lutte durable, des enquêtes géographiques, entomologiques et parasitologiques de bases ont été menées dans le foyer de THA de Sinfra ; et des actions de lutte combinées et intégrées ciblant les humains, les tsé-tsé, le bétail et les porcs domestiques ont été proposées. Résultats : Les plus fortes densités de Glossina palpalis palpalis, ont été trouvées dans et autour des villages où les porcs villageois en divagation sont présents. Ces porcs sont les plus infectés de tous les animaux par des trypanosomes (85,7%) et constituent l'alimentation préférée des tsé-tsé (87%). Conclusion: Les animaux domestiques comme les porcs pourraient jouer un rôle dans l'épidémiologie de la THA. Cela suggère leur prise en compte dans les stratégies de lutte basées sur le concept one health, dans un contexte d'élimination durable.

Published
2018

39. Modalités d'épandage des pesticides en zone de forêt ombrophile (Méagui, Côte d'Ivoire), au regard de la survie des glossines

Author

Krouba, Débora, Ouattara, Aboubacar, Kouakou, A., Coulibaly, Bamoro, Kaba, Dramane, Rayaissé, Jean-Baptiste, Gimonneau, Geoffrey, Koffi, Julius, Anoh, Paul, Kaudjhiss, J., and Courtin, Fabrice

Abstract

Introduction En Côte d'Ivoire, la région de Méagui a été mise en valeur tardivement, mais elle affiche des densités de population pouvant atteindre plus de 400 hab/km2. Dans cette région, parallèlement aux fortes densités de population humaine, il a été mis en évidence une disparition des glossines sur de vastes superficies. On suspecte l'impact de l'anthropisation sur la disparition des glossines, et notamment l'utilisation massive de pesticides. Matériels et méthodes Nous avons cherché à déterminer les modalités d'utilisation des pesticides (produits, quantité, fréquence) dans une zone allant de la ville de Méagui jusqu'au parc national de Tai. Pour cela, à l'aide du GPS, nous avons délimité 100 parcelles de cultures (cacao-café, hévéa, riz, maraicher) traitées avec des pesticides. Un questionnaire sur les modalités d'utilisation des pesticides a été soumis aux paysans propriétaires des parcelles délimitées. Résultats Au total, 74 pesticides différents ont été cités par les paysans, parmi lesquels 48 insecticides et 26 herbicides. En moyenne, la fréquence de pulvérisation des parcelles à l'aide de pesticides est estimée à 3 fois dans l'année. L'ensemble des parcelles enquêtées, d'une superficie totale de 335 hectares, reçoit une application annuelle de 1623 litres de pesticides (4,8 l/hectare). L'insecticide le plus utilisé par les paysans est la grosudine dont la substance active contient la bifenthrine appartenant à la famille des pyréthrinoides de synthèse. Conclusion Les modalités d'épandage de pesticides adoptées par les paysans ont probablement des conséquences sur les densités de glossines et donc sur le risque des trypanosomoses.

Published
2018

40. The maximum likelihood identification method applied to insect morphometric data

Author

Dujardin, Jean-Pierre, Dujardin, Sebastien, Kaba, Dramane, Santillán-Guayasamín, Soledad, Villacís, Anita G., Piyaselakul, Sitha, Sumruayphol, Suchada, Samung, Yudthana, and Vargas, Ronald Morales

Subjects
Biodiversity, Taxonomy
Abstract

Dujardin, Jean-Pierre, Dujardin, Sebastien, Kaba, Dramane, Santillán-Guayasamín, Soledad, Villacís, Anita G., Piyaselakul, Sitha, Sumruayphol, Suchada, Samung, Yudthana, Vargas, Ronald Morales (2017): The maximum likelihood identification method applied to insect morphometric data. Zoological Systematics 42 (1): 46-58, DOI: 10.11865/zs.201704

Published
2017

41. Café-cacao de Côte d'Ivoire et trypanosomiase humaine africaine (2CI-THA)

Author

Fauret, Pierre, Coulibaly, Bamoro, Ouattara, Aboubacar, Krouba, Débora, Kouakou, Colette, Berté, Djakaridja, Ta Bi Tra, Dieudonné, Adopo, Régina, Gabé, Anicet, Adingra, Pacôme, N'Dri, Louis, Kouadio, Koffi, Djohan, Vincent, Jamonneau, Vincent, Koffi, Mathurin, Rayaissé, Jean-Baptiste, Gimonneau, Geoffrey, Kouakou, Lingué, Koffi, Julius, Calas, Bernard, Assi-Kaudjhis, Joseph, Anoh, Paul, Solano, Philippe, Kaba, Dramane, Courtin, Fabrice, Fauret, Pierre, Coulibaly, Bamoro, Ouattara, Aboubacar, Krouba, Débora, Kouakou, Colette, Berté, Djakaridja, Ta Bi Tra, Dieudonné, Adopo, Régina, Gabé, Anicet, Adingra, Pacôme, N'Dri, Louis, Kouadio, Koffi, Djohan, Vincent, Jamonneau, Vincent, Koffi, Mathurin, Rayaissé, Jean-Baptiste, Gimonneau, Geoffrey, Kouakou, Lingué, Koffi, Julius, Calas, Bernard, Assi-Kaudjhis, Joseph, Anoh, Paul, Solano, Philippe, Kaba, Dramane, and Courtin, Fabrice

Published
2018

42. The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Cote d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense

Author

N’Djetchi, Martial Kassi, Ilboudo, Hamidou, Koffi, Mathurin, Kaboré, Jacques, Kaboré, Justin Windingoudi, Kaba, Dramane, Courtin, Fabrice, Coulibaly, Bamoro, Fauret, Pierre, Kouakou, Lingué, Ravel, Sophie, Deborggraeve, Stijn, Solano, Philippe, De Meeûs, Thierry, Bucheton, Bruno, and Jamonneau, Vincent

Subjects
Swine Diseases, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Swine, lcsh:Public aspects of medicine, Trypanosoma brucei gambiense, Cattle Diseases, lcsh:RA1-1270, Cote d'Ivoire, Trypanosomiasis, African, parasitic diseases, Animals, Humans, Cattle, Research Article, Disease Reservoirs
Abstract

Background Important control efforts have led to a significant reduction of the prevalence of human African trypanosomiasis (HAT) in Côte d’Ivoire, but the disease is still present in several foci. The existence of an animal reservoir of Trypanosoma brucei gambiense may explain disease persistence in these foci where animal breeding is an important source of income but where the prevalence of animal African trypanosomiasis (AAT) is unknown. The aim of this study was to identify the trypanosome species circulating in domestic animals in both Bonon and Sinfra HAT endemic foci. Methodology/Principal findings 552 domestic animals (goats, pigs, cattle and sheep) were included. Blood samples were tested for trypanosomes by microscopic observation, species-specific PCR for T. brucei sl, T. congolense, T. vivax and subspecies-specific PCR for T. b. gambiense and T. b. gambiense immune trypanolysis (TL). Infection rates varied significantly between animal species and were by far the highest in pigs (30%). T. brucei s.l was the most prevalent trypanosome species (13.7%) followed by T. congolense. No T. b. gambiense was identified by PCR while high TL positivity rates were observed using T. b. gambiense specific variants (up to 27.6% for pigs in the Bonon focus). Conclusion This study shows that domestic animals are highly infected by trypanosomes in the studied foci. This was particularly true for pigs, possibly due to a higher exposure of these animals to tsetse flies. Whereas T. brucei s.l. was the most prevalent species, discordant results were obtained between PCR and TL regarding T. b. gambiense identification. It is therefore crucial to develop better tools to study the epidemiological role of potential animal reservoir for T. b. gambiense. Our study illustrates the importance of “one health” approaches to reach HAT elimination and contribute to AAT control in the studied foci., Author summary In Africa, significant efforts to control human African trypanosomiasis (HAT) over the past three decades have drastically reduced the prevalence of the disease and elimination seems today an achievable goal. However, potential animal reservoirs of Trypanosoma brucei gambiense may compromise this ambitious objective. In the Bonon and Sinfra HAT endemic foci in Côte d’Ivoire, no recent data are available about the prevalence of animal African trypanosomiasis (AAT). The aim of this study was to identify trypanosomes circulating in domestic animals in these two HAT foci using serological, parasitological and molecular tools. We showed that T. brucei s.l. and T. congolense were the most prevalent trypanosome species and that pigs and cattle were the most infected animals. Discordant results were observed between the T. b. gambiense specific molecular and serological tools and the presence of an animal reservoir for T. b. gambiense remains unclear. Nevertheless, improved control strategies can be proposed based on this study to reach HAT elimination and contribute to AAT control in the study areas.

Published
2017

43. Tsetse Control and the Elimination of Gambian Sleeping Sickness

Author

Bates, Paul Andrew, Lehane, Mike, Alfaroukh, Idriss, Bucheton, Bruno, Camara, Mamadou, Harris, Angi, Kaba, Dramane, Lumbala, Crispin, Peka, Mallaye, Rayaisse, Jean-Baptiste, Waiswa, Charles, Solano, Philippe, and Torr, Steve

Subjects
wc_705, qx_70, qx_505, wa_110
Published
2016

44. The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Côte d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense

Author

N’Djetchi, Martial Kassi, primary, Ilboudo, Hamidou, additional, Koffi, Mathurin, additional, Kaboré, Jacques, additional, Kaboré, Justin Windingoudi, additional, Kaba, Dramane, additional, Courtin, Fabrice, additional, Coulibaly, Bamoro, additional, Fauret, Pierre, additional, Kouakou, Lingué, additional, Ravel, Sophie, additional, Deborggraeve, Stijn, additional, Solano, Philippe, additional, De Meeûs, Thierry, additional, Bucheton, Bruno, additional, and Jamonneau, Vincent, additional

Published
2017
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46. THE IMMUNE TRYPANOLYSIS TEST: AN ACCURATE SEROLOGICAL MARKER TO MANAGE ELIMINATION OFT.B. GAMBIENSEHUMAN AFRICAN TRYPANOSOMIASIS

Author

Emilie, Dama, primary, Camara, Oumou, additional, Mathurin, Koffi, additional, Guiguigbaza-Kossigan, Dayo, additional, Philippe, Büscher, additional, Regassa, Fikru, additional, Hassane, Sakande, additional, Bienvenu, Somda Martin, additional, Ilboudo, Hamidou, additional, Fabrice, Courtin, additional, Ouédraogo, Elie, additional, Kouakou, Lingue, additional, Kaba, Dramane, additional, Camara, Mamady, additional, Bucheton, Bruno, additional, Lejon, Veerle, additional, and Jamonneau, Vincent, additional

Published
2017
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47. Tsetse Control and the Elimination of Gambian Sleeping Sickness

Author

Lehane, Mike, primary, Alfaroukh, Idriss, additional, Bucheton, Bruno, additional, Camara, Mamadou, additional, Harris, Angi, additional, Kaba, Dramane, additional, Lumbala, Crispin, additional, Peka, Mallaye, additional, Rayaisse, Jean-Baptiste, additional, Waiswa, Charles, additional, Solano, Philippe, additional, and Torr, Steve, additional

Published
2016
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48. Standardising Visual Control Devices for Tsetse Flies: Central and West African Species Glossina palpalis palpalis

Author

Kaba, Dramane, Zacarie, Tusevo, M'Pondi, Alexis Makumyaviri, Njiokou, Flobert, Bosson-Vanga, Henriette, Kröber, Thomas, McMullin, Andrew, Mihok, Steve, Guerin, Patrick M, Kaba, Dramane, Zacarie, Tusevo, M'Pondi, Alexis Makumyaviri, Njiokou, Flobert, Bosson-Vanga, Henriette, Kröber, Thomas, McMullin, Andrew, Mihok, Steve, and Guerin, Patrick M

Abstract

Background: Glossina palpalis palpalis (G. p. palpalis) is one of the principal vectors of sleeping sickness and nagana in Africa with a geographical range stretching from Liberia in West Africa to Angola in Central Africa. It inhabits tropical rain forest but has also adapted to urban settlements. We set out to standardize a long-lasting, practical and cost-effective visually attractive device that would induce the strongest landing response by G. p. palpalis for future use as an insecticide impregnated tool in area-wide population suppression of this fly across its range. Methodology/Principal Findings: Trials were conducted in wet and dry seasons in the Ivory Coast, Cameroon, the Democratic Republic of Congo and Angola to measure the performance of traps (biconical, monoconical and pyramidal) and targets of different sizes and colours, with and without chemical baits, at different population densities and under different environmental conditions. Adhesive film was used as a practical enumerator at these remote locations to compare landing efficiencies of devices. Independent of season and country, both phthalogen blue-black and blue-black-blue 1 m2 targets covered with adhesive film proved to be as good as traps in phthalogen blue or turquoise blue for capturing G. p. palpalis. Trap efficiency varied (8–51%). There was no difference between the performance of blue-black and blue-blackblue 1 m2 targets. Baiting with chemicals augmented the overall performance of targets relative to traps. Landings on smaller phthalogen blue-black 0.25 m2 square targets were not significantly different from either 1 m2 blue-black-blue or blue-black square targets. Three times more flies were captured per unit area on the smaller device. Conclusions/Significance:Blue-black 0.25 m2 cloth targets show promise as simple cost effective devices for management of G. p. palpalis as

Published
2015

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