1. Metabolic syndrome and risk of endometrial cancer in postmenopausal women: a prospective study
- Author
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Arthur, Rhonda S, Kabat, Geoffrey C, Kim, Mimi Y, Wild, Robert A, Shadyab, Aladdin H, Wactawski-Wende, Jean, Ho, Gloria YF, Reeves, Katherine W, Kuller, Lewis H, Luo, Juhua, Beebe-Dimmer, Jennifer, Simon, Michael S, Strickler, Howard, Wassertheil-Smoller, Sylvia, and Rohan, Thomas E
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Obesity ,Uterine Cancer ,Aging ,Nutrition ,Cancer ,Prevention ,Aged ,Body Mass Index ,Cohort Studies ,Dyslipidemias ,Endometrial Neoplasms ,Female ,Humans ,Hypertension ,Metabolic Syndrome ,Middle Aged ,Postmenopause ,Prospective Studies ,Risk Factors ,Waist Circumference ,Metabolic syndrome ,Abdominal adiposity ,Endometrial cancer ,Postmenopausal women ,Oncology and Carcinogenesis ,Public Health and Health Services ,Oncology and carcinogenesis - Abstract
BackgroundObesity is a strong risk factor for endometrial cancer, but it is unclear whether metabolic syndrome (MetS) contributes to endometrial cancer risk over and above the contribution of obesity.MethodsWe examined the association of MetS and its components with risk of endometrial cancer in a sub-cohort of 24,210 women enrolled in the Women's Health Initiative cohort study. Two variants of the National Cholesterol Education Program Adult Treatment Panel III definition of the MetS were used: one including and one excluding waist circumference (WC). Cox proportional hazards models were used to estimate the association of the study exposures with disease risk.ResultsWhen WC was included in the definition, MetS showed an approximately two-fold increase in endometrial cancer risk (HR 2.20; 95% CI 1.61-3.02); however, when WC was excluded, MetS was no longer associated with risk. We also observed that women with hyperglycemia, dyslipidemia and hypertension, in combination, had almost a twofold increased risk of endometrial cancer, independent of WC (HR 1.94; 95% CI 1.09, 3.46). Glucose, and, in particular, WC and body mass index were also positively associated with risk.ConclusionsOur findings suggest that MetS may predict risk of endometrial cancer independent of obesity among women with the remaining four Mets components.
- Published
- 2019