Search

Abstracts: Background: Pregnant women are particularly vulnerable to lead toxicity due to increased absorption and decreased elimination of lead from their bodies. The δ-aminolevulinic acid dehydratase (ALAD) gene plays a crucial role in lead metabolism, and its polymorphisms have been implicated in modifying the susceptibility to lead toxicity. Methods: A cross-sectional study was conducted involving 90 pregnant women and blood samples were collected to measure blood lead levels (BLL) and assessed DNA damage using the comet assay. ALAD polymorphisms were genotyped using PCR-RFLP analysis with MspI restriction enzyme. Statistical analysis, including chi-square tests, logistic regression, and correlation analysis, was performed to determine associations between ALAD polymorphisms, BLL, and DNA damage. Results: From 90 pregnant women the participants, 16 had high BLL (≥5 μg/dL), while the remaining 74 had normal levels (

Introduction: In developing countries like India, low birth weight is a major public health issue. It is a leading cause of disease and mortality in infants. Low birth weight can be avoided by identifying at-risk pregnant women and taking the necessary precautions. Methods: From January to June 2019, a facility based retrospective case control study was conducted among pregnant women who gave birth at the hospitals. The information was gathered from the antenatal care files and the delivery room register and records. SPSS version 24.0 was used to process the data. To find an independent predictor of low birth weight, researchers used binary and multiple bivariate logistic regressions. Result: An aggregate of 450 neonatal birth records were reviewed in this study of which 150 were low birth weight babies and 300 were of normal birth weight. The mean ± SD and median [IQR] for birth weight of case group was [2.0±0.4kg, 2.2[1.8-2.4] kg] and that for control [3.1±0.4kg, 3.0[2.7-3.3] kg] respectively. Conclusion: Preterm delivery, mothers with hypothyroidism have an increased chance of having low birth weight babies whereas mothers with regular antenatal check-up and mothers with primary and secondary education have a lesser possibility of having low birth weight babies.

Aims: This study is aimed at finding out a logical solution for perimenopausal menorrhagia in normal or bulky uterus. Settings and Design: The study is carried out at a tertiary care hospital at Odisha. In our setup, nearly 900 hysterectomies are done per year out of which 60% are for menorrhagia with bulky uterus. Subjects and Methods: There were sixty cases of menorrhagia between the ages of 40 and 55 years who completed child bearing treated with ormeloxifene. Their endometrial thickness (ET) and hemoglobin (Hb) level were determined at the start of the study and also at 6 months and compared. At 1 year from the start of treatment, patients' satisfaction and status of menstrual cycle were reassessed. Statistical Analysis Used: Age and parity variables were expressed as mean ± standard deviation and range. We used the paired samples t-test to estimate the mean, median, range, P and t value. All statistical analyses were performed using SPSS software version 11.5 (IBM Corp) and tests of statistical significance were two-sided and differences were taken as significant when P < 0.05. Results: After 1 year of follow-up, 90% of patients found to be amenorrhoic and only two out of them presented with mild irritability and vasomotor complaints which resolved with counseling and placebo therapy. There was a significant reduction (P < 0.0001) in ET and rise in Hb level (P < 0.0001). Conclusions: Ormeloxifene is a safe drug which can be used to treatment of perimenopausal bleeding with minimal focal pathology.