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2. Disease trajectories in interstitial lung diseases – data from the EXCITING-ILD registry

Author

Buschulte, Katharina, Kabitz, Hans-Joachim, Hagmeyer, Lars, Hammerl, Peter, Esselmann, Albert, Wiederhold, Conrad, Skowasch, Dirk, Stolpe, Christoph, Joest, Marcus, Veitshans, Stefan, Höffgen, Marc, Maqhuzu, Phillen, Schwarzkopf, Larissa, Hellmann, Andreas, Pfeifer, Michael, Behr, Jürgen, Karpavicius, Rainer, Günther, Andreas, Polke, Markus, Höger, Philipp, Somogyi, Vivien, Lederer, Christoph, Markart, Philipp, and Kreuter, Michael

Published
2024
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3. Hospitalisation patterns in interstitial lung diseases: data from the EXCITING-ILD registry

Author

Buschulte, Katharina, Kabitz, Hans-Joachim, Hagmeyer, Lars, Hammerl, Peter, Esselmann, Albert, Wiederhold, Conrad, Skowasch, Dirk, Stolpe, Christoph, Joest, Marcus, Veitshans, Stefan, Höffgen, Marc, Maqhuzu, Phillen, Schwarzkopf, Larissa, Hellmann, Andreas, Pfeifer, Michael, Behr, Jürgen, Karpavicius, Rainer, Günther, Andreas, Polke, Markus, Höger, Philipp, Somogyi, Vivien, Lederer, Christoph, Markart, Philipp, and Kreuter, Michael

Published
2024
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5. Risk stratification and response to therapy in patients with pulmonary arterial hypertension and comorbidities: A COMPERA analysis

Author

Rosenkranz, Stephan, Pausch, Christine, Coghlan, John G., Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Vizza, Carmine Dario, Gall, Henning, Distler, Oliver, Delcroix, Marion, Ghofrani, Hossain A., Ewert, Ralf, Kabitz, Hans-Joachim, Skowasch, Dirk, Behr, Juergen, Milger, Katrin, Halank, Michael, Wilkens, Heinrike, Seyfarth, Hans-Jürgen, Held, Matthias, Scelsi, Laura, Neurohr, Claus, Vonk-Noordegraaf, Anton, Ulrich, Silvia, Klose, Hans, Claussen, Martin, Eisenmann, Stephan, Schmidt, Kai-Helge, Remppis, Bjoern Andrew, Skride, Andris, Jureviciene, Elena, Gumbiene, Lina, Miliauskas, Skaidrius, Löffler-Ragg, Judith, Lange, Tobias J., Olsson, Karen M., Hoeper, Marius M., and Opitz, Christian

Published
2023
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6. Phenotyping of idiopathic pulmonary arterial hypertension: a registry analysis

Author

Hoeper, Marius M, Dwivedi, Krit, Pausch, Christine, Lewis, Robert A, Olsson, Karen M, Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Vizza, Carmine Dario, Gall, Henning, Distler, Oliver, Opitz, Christian, Gibbs, John Simon R, Delcroix, Marion, Park, Da-Hee, Ghofrani, Hossein Ardeschir, Ewert, Ralf, Kaemmerer, Harald, Kabitz, Hans-Joachim, Skowasch, Dirk, Behr, Juergen, Milger, Katrin, Lange, Tobias J, Wilkens, Heinrike, Seyfarth, Hans-Jürgen, Held, Matthias, Dumitrescu, Daniel, Tsangaris, Iraklis, Vonk-Noordegraaf, Anton, Ulrich, Silvia, Klose, Hans, Claussen, Martin, Eisenmann, Stephan, Schmidt, Kai-Helge, Swift, Andrew J, Thompson, Alfred A Roger, Elliot, Charlie A, Rosenkranz, Stephan, Condliffe, Robin, Kiely, David G, and Halank, Michael

Published
2022
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7. Allgemeine Maßnahmen und Management der pulmonalarteriellen Hypertonie

Author

Lichtblau, Mona, additional, Harutyunova, Satenik, additional, Nechwatal, Robert, additional, Mayer, Laura, additional, Kabitz, Hans-Joachim, additional, Wilkens, Finn Moritz, additional, Uiker, Sören, additional, Grünig, Ekkehard, additional, Ritter, Daniel, additional, Florea, Andreea, additional, and Benjamin, Nicola, additional

Published
2023
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9. Genetic Heterogeneity of MET-Aberrant NSCLC and Its Impact on the Outcome of Immunotherapy

Author

Kron, Anna, Scheffler, Matthias, Heydt, Carina, Ruge, Lea, Schaepers, Carsten, Eisert, Anna-Kristina, Merkelbach-Bruse, Sabine, Riedel, Richard, Nogova, Lucia, Fischer, Rieke Nila, Michels, Sebastian, Abdulla, Diana S.Y., Koleczko, Sophia, Fassunke, Jana, Schultheis, Anne M., Kron, Florian, Ueckeroth, Frank, Wessling, Gabriele, Sueptitz, Juliane, Beckers, Frank, Braess, Jan, Panse, Jens, Grohé, Christian, Hamm, Michael, Kabitz, Hans-Joachim, Kambartel, Kato, Kaminsky, Britta, Krueger, Stefan, Schulte, Clemens, Lorenz, Joachim, Lorenzen, Johann, Meister, Wolfram, Meyer, Andreas, Kappes, Jutta, Reinmuth, Niels, Schaaf, Bernhard, Schulte, Wolfgang, Serke, Monika, Buettner, Reinhard, and Wolf, Jürgen

Published
2021
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10. Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry

Author

Hoeper, Marius M., Pausch, Christine, Grünig, Ekkehard, Klose, Hans, Staehler, Gerd, Huscher, Doerte, Pittrow, David, Olsson, Karen M., Vizza, Carmine Dario, Gall, Henning, Benjamin, Nicola, Distler, Oliver, Opitz, Christian, Gibbs, J. Simon R., Delcroix, Marion, Ghofrani, H. Ardeschir, Rosenkranz, Stephan, Ewert, Ralf, Kaemmerer, Harald, Lange, Tobias J., Kabitz, Hans-Joachim, Skowasch, Dirk, Skride, Andris, Jureviciene, Elena, Paleviciute, Egle, Miliauskas, Skaidrius, Claussen, Martin, Behr, Juergen, Milger, Katrin, Halank, Michael, Wilkens, Heinrike, Wirtz, Hubert, Pfeuffer-Jovic, Elena, Harbaum, Lars, Scholtz, Werner, Dumitrescu, Daniel, Bruch, Leonhard, Coghlan, Gerry, Neurohr, Claus, Tsangaris, Iraklis, Gorenflo, Matthias, Scelsi, Laura, Vonk-Noordegraaf, Anton, Ulrich, Silvia, and Held, Matthias

Published
2020
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15. Patient*innen-Sicherheit 4.0: 'Fehler der Woche' – Um die Vorbildfunktion geht’s!

Author

Ulmer, Francis, Krings, Rabea, Häberli, Christoph, Bally, Romina, Schuchmann, Marcus, Huwendiek, Sören, and Kabitz, Hans-Joachim

Subjects
610 Medicine & health, 370 Education
Abstract

BACKGROUND The rate of mistakes and near misses in clinical medicine remains staggering. The tendency to cover up mistakes is rampant in "name-blame-shame" cultures. The need for safe forums where mistakes can be openly discussed in the interest of patient safety is evident. Following a comprehensive review of the literature, a semi-structured weekly conference, named "mistake of the week" (MOTW), was introduced, enabling physicians to voluntarily discuss their mistakes and near-misses. The MOTW is intended to encourage cultural change in how physicians approach, process, accept and learn from their own and their peers' mistakes. This study seeks to assess if physicians appreciate, benefit from and are motivated to participate in MOTW. METHODS Physicians and medical students of the I. and II. Medizinische Klinik at the Academic Teaching Hospital Klinikum Konstanz (Germany) were eligible to participate voluntarily. Four groups of physicians (n=3-6) and one group of medical students (n=5) volunteered to participate in focus group interviews, which were videotaped, transcribed and analyzed. RESULTS The following success factors are crucial for dealing with and voluntarily disclosing mistakes and near-misses: 1. Exemplification ("follow the boss's lead"), 2. Fixed time slots and a clear forum, 3. Reporting mistakes without fear of penalty or punishment, 4. A trusting working atmosphere. The key effects of the MOTW approach are: 1. People report their mistakes more, 2. Relief, 3. Psychological safety, 4. Lessons learned/errors (potentially) reduced. DISCUSSION The MOTW conference models an ideal forum to mitigate hierarchy and promote a sustainable organizational dynamic in which mistakes and near misses can be discussed in an environment free from "name-blame-shame", with the ultimate goal of potentially improving patient care and safety., Hintergrund (Beinahe-)Fehler kommen im komplexen Gesundheitswesen häufig vor. Hierarchisch geprägte Strukturen begünstigen eine Fehlerkultur des „Name – Blame – Shame“ (benenne, klage an, beschäme), (Beinahe-)Fehler werden vertuscht, verharmlost oder totgeschwiegen. Eine der größten Herausforderungen der modernen Medizin ist die Schaffung eines Umfelds, welches durch offene Berichterstattung (Beinahe-)Fehler systematisch analysiert und ermöglicht, daraus etwas zu lernen. Ärzt*innen haben hierbei wegen des ausgeprägten Hierarchiegefüges und des traditionellen Rollenverständnisses eine Schlüsselfunktion. Methoden Nach entsprechender Literaturanalyse wurde das flächendeckend anzuwendende Modell „Fehler der Woche“ (FdW) entwickelt, welches jedem (ärztlichen) Teammitglied erlaubt, offen über (Beinahe-)Fehler zu berichten. Fünf Fokusgruppen wurden durchgeführt und gemäß qualitativem Forschungsansatz via thematischer Analyse ausgewertet. Ergebnisse Folgende wesentliche Erfolgsfaktoren für einen angstfreien Umgang mit (Beinahe-)Fehlern (Modell FdW) wurden identifiziert: 1. Vorbildfunktion („Der Chef macht’s vor“), 2. fester Zeitslot/„Fehlerbühne“, 3. sanktionsfreies Berichten eigener Fehler, 4. vertrauensvolles Arbeitsklima. Folgende relevanten Auswirkungen resultierten hieraus: 1. eigene Fehler werden häufiger berichtet, 2. Erleichterung/Entlastung, 3. psychologische Sicherheit, 4. Lerneffekt. Diskussion Das Modell „Fehler der Woche“ ist in der Lage, einen nachhaltigen Kulturwandel einzuleiten, gemäß dem Motto „ich bin gewiss nicht stolz darauf, dass mir ein (Beinahe-)Fehler unterlaufen ist – jedoch sehr stolz darauf, dass ich im Sinne der Patient*innen-Sicherheit darüber reden kann“.

Published
2023

16. Do cardiopulmonary exercise tests predict summit success and acute mountain sickness? A prospective observational field study at extreme altitude

Author

Seiler, Thomas, primary, Nakas, Christos T, additional, Brill, Anne-Kathrin, additional, Hefti, Urs, additional, Hilty, Matthias Peter, additional, Perret-Hoigné, Eveline, additional, Sailer, Jannis, additional, Kabitz, Hans-Joachim, additional, Merz, Tobias M, additional, and Pichler Hefti, Jacqueline, additional

Published
2023
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19. Consensus guideline on the interdisciplinary diagnosis of interstitial lung diseases

Author

Kreuter, Michael, Behr, Jürgen, Bonella, Francesco, Costabel, Ulrich, Gerber, Alexander, Hamer, Okka W., Heussel, Claus Peter, Jonigk, Danny, Krause, Andreas, Koschel, Dirk, Leuschner, Gabriela, Markart, Philipp, Nowak, Dennis, Pfeifer, Michael, Wälscher, Julia, Prasse, Antje, Winter, Hauke, Kabitz, Hans-Joachim, and Publica

Subjects
Pulmonary and Respiratory Medicine, Medizin
Abstract

ZusammenfassungDie Beurteilung von Patienten mit v. a. einer interstitiellen Lungenerkrankung (ILD) umfasst die Beurteilung klinischer, radiologischer und oft histopathologischer Daten. Da bislang noch keine dezidierten Empfehlungen für die Evaluation bei Verdacht auf eine ILD in Deutschland existierten, war es Ziel dieses interdisziplinären Konsensusstatements, eine praktische Orientierungshilfe für den klinischen Alltag in Bezug auf die interdisziplinäre Diagnostik der ILDs zu geben. Dazu gehören die umfassende klinisch-pneumologische und in vielen Fällen auch eine rheumatologische Beurteilung, radiologische Diagnostik sowie Probenentnahme zur histopathologischen Evaluation sowie die abschließende Diskussion im multidisziplinären Team.

Published
2023

20. [Untitled]

Author

Ulmer, Francis, Krings, Rabea, Häberli, Christoph, Bally, Romina, Schuchmann, Marcus, Huwendiek, Sören, and Kabitz, Hans-Joachim

Subjects
370 Education, 610 Medicine & health
Abstract

BACKGROUND The rate of mistakes and near misses in clinical medicine remains staggering. The tendency to cover up mistakes is rampant in "name-blame-shame" cultures. The need for safe forums where mistakes can be openly discussed in the interest of patient safety is evident. Following a comprehensive review of the literature, a semi-structured weekly conference, named "mistake of the week" (MOTW), was introduced, enabling physicians to voluntarily discuss their mistakes and near-misses. The MOTW is intended to encourage cultural change in how physicians approach, process, accept and learn from their own and their peers' mistakes. This study seeks to assess if physicians appreciate, benefit from and are motivated to participate in MOTW. METHODS Physicians and medical students of the I. and II. Medizinische Klinik at the Academic Teaching Hospital Klinikum Konstanz (Germany) were eligible to participate voluntarily. Four groups of physicians (n=3-6) and one group of medical students (n=5) volunteered to participate in focus group interviews, which were videotaped, transcribed and analyzed. RESULTS The following success factors are crucial for dealing with and voluntarily disclosing mistakes and near-misses: 1. Exemplification ("follow the boss's lead"), 2. Fixed time slots and a clear forum, 3. Reporting mistakes without fear of penalty or punishment, 4. A trusting working atmosphere. The key effects of the MOTW approach are: 1. People report their mistakes more, 2. Relief, 3. Psychological safety, 4. Lessons learned/errors (potentially) reduced. DISCUSSION The MOTW conference models an ideal forum to mitigate hierarchy and promote a sustainable organizational dynamic in which mistakes and near misses can be discussed in an environment free from "name-blame-shame", with the ultimate goal of potentially improving patient care and safety., Hintergrund (Beinahe-)Fehler kommen im komplexen Gesundheitswesen häufig vor. Hierarchisch geprägte Strukturen begünstigen eine Fehlerkultur des „Name – Blame – Shame“ (benenne, klage an, beschäme), (Beinahe-)Fehler werden vertuscht, verharmlost oder totgeschwiegen. Eine der größten Herausforderungen der modernen Medizin ist die Schaffung eines Umfelds, welches durch offene Berichterstattung (Beinahe-)Fehler systematisch analysiert und ermöglicht, daraus etwas zu lernen. Ärzt*innen haben hierbei wegen des ausgeprägten Hierarchiegefüges und des traditionellen Rollenverständnisses eine Schlüsselfunktion. Methoden Nach entsprechender Literaturanalyse wurde das flächendeckend anzuwendende Modell „Fehler der Woche“ (FdW) entwickelt, welches jedem (ärztlichen) Teammitglied erlaubt, offen über (Beinahe-)Fehler zu berichten. Fünf Fokusgruppen wurden durchgeführt und gemäß qualitativem Forschungsansatz via thematischer Analyse ausgewertet. Ergebnisse Folgende wesentliche Erfolgsfaktoren für einen angstfreien Umgang mit (Beinahe-)Fehlern (Modell FdW) wurden identifiziert: 1. Vorbildfunktion („Der Chef macht’s vor“), 2. fester Zeitslot/„Fehlerbühne“, 3. sanktionsfreies Berichten eigener Fehler, 4. vertrauensvolles Arbeitsklima. Folgende relevanten Auswirkungen resultierten hieraus: 1. eigene Fehler werden häufiger berichtet, 2. Erleichterung/Entlastung, 3. psychologische Sicherheit, 4. Lerneffekt. Diskussion Das Modell „Fehler der Woche“ ist in der Lage, einen nachhaltigen Kulturwandel einzuleiten, gemäß dem Motto „ich bin gewiss nicht stolz darauf, dass mir ein (Beinahe-)Fehler unterlaufen ist – jedoch sehr stolz darauf, dass ich im Sinne der Patient*innen-Sicherheit darüber reden kann“.

Published
2023
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22. Response to: Low molecular weight guluronate: A potential therapies for inspiratory muscle dysfunction and restrictive lung function impairment in congenital heart disease by Guiyuan He, Ruiting Zhou, Tingyuan Huang, Fanjun Zeng

Author

Spiesshoefer, Jens, primary, Regmi, Binaya, additional, Orwat, Stefan, additional, Kabitz, Hans-Joachim, additional, Giannoni, Alberto, additional, Dreher, Michael, additional, Boentert, Matthias, additional, and Diller, Gerhard Paul, additional

Published
2022
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24. Prognostic value of improvement endpoints in pulmonary arterial hypertension trials: A COMPERA analysis

Author

Hoeper, Marius M., primary, Pausch, Christine, additional, Olsson, Karen M., additional, Huscher, Doerte, additional, Pittrow, David, additional, Grünig, Ekkehard, additional, Staehler, Gerd, additional, Vizza, Carmine Dario, additional, Gall, Henning, additional, Distler, Oliver, additional, Opitz, Christian, additional, Gibbs, J. Simon R., additional, Delcroix, Marion, additional, Ghofrani, H. Ardeschir, additional, Ewert, Ralf, additional, Kaemmerer, Harald, additional, Kabitz, Hans-Joachim, additional, Skowasch, Dirk, additional, Behr, Juergen, additional, Milger, Katrin, additional, Halank, Michael, additional, Wilkens, Heinrike, additional, Seyfarth, Hans-Jürgen, additional, Held, Matthias, additional, Dumitrescu, Daniel, additional, Tsangaris, Iraklis, additional, Vonk-Noordegraaf, Anton, additional, Ulrich, Silvia, additional, Klose, Hans, additional, Claussen, Martin, additional, Eisenmann, Stephan, additional, Schmidt, Kai-Helge, additional, Rosenkranz, Stephan, additional, and Lange, Tobias J., additional

Published
2022
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25. Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years

Author

Soliman, Ivo, Leaver, Susannah, Flaatten, Hans, Fjølner, Jesper, Wernly, Bernhard, Bruno, Raphael, Artigas, Antonio, Bollen Pinto, Bernardo, Schefold, Joerg, Beil, Michael, Sviri, Sigal, van Heerden, Peter Vernon, Szczeklik, Wojciech, Elhadi, Muhammed, Joannidis, Michael, Oeyen, Sandra, Zafeiridis, Tilemachos, Wollborn, Jakob, Banzo, Maria Jose Arche, Fuest, Kristina, Marsh, Brian, Andersen, Finn, Moreno, Rui, Boumendil, Ariane, Guidet, Bertrand, Jung, Christian, de Lange, Dylan, Eller, Philipp, Mesotten, Dieter, Reper, Pascal, Swinnen, Walter, Brix, Helene, Brushoej, Jens, Villefrance, Maja, Nedergaard, Helene Korvenius, Bjerregaard, Anders Thais, Balleby, Ida Riise, Andersen, Kasper, Hansen, Maria Aagaard, Uhrenholt, Stine, Bundgaard, Helle, Mohamed, Aliae Ar Hussein, Salah, Rehab, Ali, Yasmin Khairy Nasreldin Mohamed, Wassim, Kyrillos, Elgazzar, Yumna, Tharwat, Samar, Azzam, Ahmed, Habib, Ayman Abdelmawgoad, Abosheaishaa, Hazem Maarouf, Azab, Mohammed, Galbois, Arnaud, Charron, Cyril, Guerot, Emmanuel, Besch, Guillaume, Rigaud, Jean-Philippe, Maizel, Julien, Djibré, Michel, Burtin, Philippe, Garcon, Pierre, Nseir, Saad, Valette, Xavier, Alexandru, Nica, Marin, Nathalie, Vaissiere, Marie, Plantefeve, Gaëtan, Vanderlinden, Thierry, Jurcisin, Igor, Megarbane, Bruno, Caillard, Anais, Valent, Arnaud, Garnier, Marc, Besset, Sebastien, Oziel, Johanna, Raphaelen, Jean-Herlé, Dauger, Stéphane, Dumas, Guillaume, Goncalves, Bruno, Piton, Gaël, Bruno, Raphael Romano, Kelm, Malte, Wolff, Georg, Barth, Eberhard, Goebel, Ulrich, Kunstein, Anselm, Schuster, Michael, Welte, Martin, Lutz, Matthias, Meybohm, Patrick, Steiner, Stephan, Poerner, Tudor, Haake, Hendrik, Schaller, Stefan, Kindgen-Milles, Detlef, Meyer, Christian, Kurt, Muhammed, Kuhn, Karl Friedrich, Randerath, Winfried, Dindane, Zouhir, Kabitz, Hans-Joachim, Voigt, Ingo, Shala, Gonxhe, Faltlhauser, Andreas, Rovina, Nikoletta, Aidoni, Zoi, Chrisanthopoulou, Evangelia, Papadogoulas, Antonios, Gurjar, Mohan, Mahmoodpoor, Ata, Ahmed, Abdullah Khudhur, Elsaka, Ahmed, Comellini, Vittoria, Rabha, Ahmed, Ahmed, Hazem, Namendys-Silva, Silvio, Ghannam, Abdelilah, Groenendijk, Martijn, Zegers, Marieke, Cornet, Alex, Evers, Mirjam, Haas, Lenneke, Dormans, Tom, Dieperink, Willem, Romundstad, Luis, Sjøbø, Britt, Strietzel, Hans Frank, Olasveengen, Theresa, Hahn, Michael, Czuczwar, Miroslaw, Gawda, Ryszard, Klimkiewicz, Jakub, de Lurdessantos, Maria Campos, Gordinho, André, Santos, Henrique, Assis, Rui, Oliveira, Ana Isabel Pinho, Badawy, Mohamed Raafat, Perez-Torres, David, Gomà, Gemma, Villamayor, Mercedes Ibarz, Mira, Angela Prado, Cubero, Patricia Jimeno, Rivera, Susana Arias, Tomasa, Teresa, Iglesias, David, Vázquez, Eric Mayor, Aldecoa, Cesar, Ferreira, Aida Fernández, Zalba-Etayo, Begoña, Canas-Perez, Isabel, Tamayo-Lomas, Luis, Diaz-Rodriguez, Cristina, Sancho, Susana, Priego, Jesús, Abualqumboz, Enas, Hilles, Momin Majed Yousuf, Saleh, Mahmoud, Ben-Hamouda, Nawfel, Roberti, Andrea, Dullenkopf, Alexander, Fleury, Yvan, Pinto, Bernardo Bollen, Al-Sadawi, Mohammed, Serck, Nicolas, Dewaele, Elisabeth, Kumar, Pritpal, Bundesen, Camilla, Innes, Richard, Gooch, James, Cagova, Lenka, Potter, Elizabeth, Reay, Michael, Davey, Miriam, Humphreys, Sally, Berlemont, Caroline Hauw, Chousterman, Benjamin Glenn, Dépret, François, Ferre, Alexis, Vettoretti, Lucie, Thevenin, Didier, Milovanovic, Milena, Simon, Philipp, Lorenz, Marco, Stoll, Sandra Emily, Dubler, Simon, Mulita, Francesk, Kondili, Eumorifa, Andrianopoulos, Ioannis, Meynaar, Iwan, Cornet, Alexander Daniel, Sjøbøe, Britt, Kluzik, Anna, Zatorski, Paweł, Drygalski, Tomasz, Solek-Pastuszka, Joanna, Onichimowski, Dariusz, Stefaniak, Jan, Stefanska-Wronka, Karina, Zabul, Ewa, Cardoso, Filipe Sousa, Banzo, Maria José Arche, Tomasa-Irriguible, Teresa Maria, Mira, Ángela Prado, Arias-Rivera, Susana, Frutos-Vivar, Fernando, Lopez-Cuenca, Sonia, de Gopegui, Pablo Ruiz, Abidi, Nour, Chau, Ivan, Pugh, Richard, Smuts, Sara, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Réanimation Médicale [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Bouchard, Mélanie, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), COVIP-study group, Eller, P., Joannidis, M., Mesotten, D., Reper, P., Oeyen, S., Swinnen, W., Brix, H., Brushoej, J., Villefrance, M., Nedergaard, H.K., Bjerregaard, A.T., Balleby, I.R., Andersen, K., Hansen, M.A., Uhrenholt, S., Bundgaard, H., Fjølner, J., Mohamed, AAH, Salah, R., Ali, YKNM, Wassim, K., Elgazzar, Y.A., Tharwat, S., Azzam, A.Y., Habib, A.A., Abosheaishaa, H.M., Azab, M.A., Leaver, S., Galbois, A., Guidet, B., Charron, C., Guerot, E., Besch, G., Rigaud, J.P., Maizel, J., Djibré, M., Burtin, P., Garcon, P., Nseir, S., Valette, X., Alexandru, N., Marin, N., Vaissiere, M., Plantefeve, G., Vanderlinden, T., Jurcisin, I., Megarbane, B., Caillard, A., Valent, A., Garnier, M., Besset, S., Oziel, J., Raphaelen, J.H., Dauger, S., Dumas, G., Goncalves, B., Piton, G., Jung, C., Bruno, R.R., Kelm, M., Wolff, G., Barth, E., Goebel, U., Kunstein, A., Schuster, M., Welte, M., Lutz, M., Meybohm, P., Steiner, S., Poerner, T., Haake, H., Schaller, S., Kindgen-Milles, D., Meyer, C., Kurt, M., Kuhn, K.F., Randerath, W., Wollborn, J., Dindane, Z., Kabitz, H.J., Voigt, I., Shala, G., Faltlhauser, A., Rovina, N., Aidoni, Z., Chrisanthopoulou, E., Papadogoulas, A., Gurjar, M., Mahmoodpoor, A., Ahmed, A.K., Marsh, B., Elsaka, A., Sviri, S., Comellini, V., Rabha, A., Ahmed, H., Namendys-Silva, S.A., Ghannam, A., Groenendijk, M., Zegers, M., de Lange, D., Cornet, A., Evers, M., Haas, L., Dormans, T., Dieperink, W., Romundstad, L., Sjøbø, B., Andersen, F.H., Strietzel, H.F., Olasveengen, T., Hahn, M., Czuczwar, M., Gawda, R., Klimkiewicz, J., de LurdesSantos, M.C., Gordinho, A., Santos, H., Assis, R., Oliveira, AIP, Badawy, M.R., Perez-Torres, D., Gomà, G., Villamayor, M.I., Mira, A.P., Cubero, P.J., Rivera, S.A., Tomasa, T., Iglesias, D., Vázquez, E.M., Aldecoa, C., Ferreira, A.F., Zalba-Etayo, B., Canas-Perez, I., Tamayo-Lomas, L., Diaz-Rodriguez, C., Sancho, S., Priego, J., Abualqumboz, EMY, Hilles, MMY, Saleh, M., Ben-HAmouda, N., Roberti, A., Dullenkopf, A., Fleury, Y., Pinto, B.B., Schefold, J.C., Al-Sadawi, M., Serck, N., Dewaele, E., Kumar, P., Bundesen, C., Innes, R., Gooch, J., Cagova, L., Potter, E., Reay, M., Davey, M., Humphreys, S., Berlemont, C.H., Chousterman, B.G., Dépret, F., Ferre, A., Vettoretti, L., Thevenin, D., Milovanovic, M., Simon, P., Lorenz, M., Stoll, S.E., Dubler, S., Fuest, K., Mulita, F., Kondili, E., Andrianopoulos, I., Meynaar, I., Cornet, A.D., Sjøbøe, B., Kluzik, A., Zatorski, P., Drygalski, T., Szczeklik, W., Solek-Pastuszka, J., Onichimowski, D., Stefaniak, J., Stefanska-Wronka, K., Zabul, E., Cardoso, F.S., Banzo, MJA, Tomasa-Irriguible, T.M., Mira, Á.P., Arias-Rivera, S., Frutos-Vivar, F., Lopez-Cuenca, S., de Gopegui, P.R., Abidi, N., Chau, I., Pugh, R., and Smuts, S.

Subjects
Aging, Activities of Daily Living, Aged, COVID-19, Humans, Intensive Care Units, Prospective Studies, Quality of Life, SARS-CoV-2, Intensive Care Unit (ICU), Older people, Survival, frailty, [SDV]Life Sciences [q-bio], SOCIETY, 610 Medicine & health, General Medicine, INTENSIVE-CARE, humanities, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], [SDV] Life Sciences [q-bio], Medicine and Health Sciences, Geriatrics and Gerontology
Abstract

Background health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected. Objective to quantify HRQoL in order to identify areas of interventions. Design prospective observation study. Setting admissions to European ICUs between March 2020 and February 2021. Subjects patients aged 70 years or older admitted with COVID-19 disease. Methods collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of ≥4 on any of Euro-QoL-5D-5L domains was considered unfavourable. Results in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71–1.87) for CFS 2 to OR 4.33 (95% CI: 1.57–11.9) for CFS ≧ 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months. Conclusions in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.

Published
2022

26. The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19

Author

Bruno, Raphael Romano, Wernly, Bernhard, Flaatten, Hans, Fjølner, Jesper, Artigas, Antonio, Baldia, Philipp Heinrich, Binneboessel, Stephan, Bollen Pinto, Bernardo, Schefold, Joerg C., Wolff, Georg, Kelm, Malte, Beil, Michael, Sviri, Sigal, van Heerden, Peter Vernon, Szczeklik, Wojciech, Elhadi, Muhammed, Joannidis, Michael, Oeyen, Sandra, Kondili, Eumorfia, Marsh, Brian, Wollborn, Jakob, Andersen, Finn H., Moreno, Rui, Leaver, Susannah, Boumendil, Ariane, De Lange, Dylan W., Guidet, Bertrand, Jung, Christian, Eller, Philipp, Mesotten, Dieter, Reper, Pascal, Swinnen, Walter, Serck, Nicolas, Dewaele, Elisabeth, Brix, Helene, Brushoej, Jens, Kumar, Pritpal, Nedergaard, Helene Korvenius, Balleby, Ida Riise, Bundesen, Camilla, Hansen, Maria Aagaard, Uhrenholt, Stine, Bundgaard, Helle, Gooch, James, Cagova, Lenka, Potter, Elizabeth, Reay, Michael, Davey, Miriam, Abusayed, Mohammed Abdelshafy, Humphreys, Sally, Galbois, Arnaud, Charron, Cyril, Berlemont, Caroline Hauw, Besch, Guillaume, Rigaud, Jean-Philippe, Maizel, Julien, Djibré, Michel, Burtin, Philippe, Garcon, Pierre, Nseir, Saad, Valette, Xavier, Alexandru, Nica, Marin, Nathalie, Vaissiere, Marie, Plantefeve, Gaëtan, Vanderlinden, Thierry, Jurcisin, Igor, Megarbane, Buno, Chousterman, Benjamin Glenn, Dépret, François, Garnier, Marc, Besset, Sebastien, Oziel, Johanna, Ferre, Alexis, Dauger, Stéphane, Dumas, Guillaume, Goncalves, Bruno, Vettoretti, Lucie, Thevenin, Didier, Schaller, Stefan, Kurt, Muhammed, Faltlhauser, Andreas, Meyer, Christian, Milovanovic, Milena, Lutz, Matthias, Shala, Gonxhe, Haake, Hendrik, Randerath, Winfried, Kunstein, Anselm, Meybohm, Patrick, Steiner, Stephan, Barth, Eberhard, Poerner, Tudor, Simon, Philipp, Lorenz, Marco, Dindane, Zouhir, Kuhn, Karl Friedrich, Welte, Martin, Voigt, Ingo, Kabitz, Hans-Joachim, Goebel, Ulrich, Stoll, Sandra Emily, Kindgen-Milles, Detlef, Dubler, Simon, Fuest, Kristina, Schuster, Michael, Papadogoulas, Antonios, Mulita, Francesk, Rovina, Nikoletta, Aidoni, Zoi, Chrisanthopoulou, Evangelia, Andrianopoulos, Ioannis, Groenendijk, Martijn, Evers, Mirjam, van Lelyveld-Haas, Lenneke, Meynaar, Iwan, Cornet, Alexander Daniel, Zegers, Marieke, Dieperink, Willem, Dormans, Tom, Hahn, Michael, Sjøbøe, Britt, Strietzel, Hans Frank, Olasveengen, Theresa, Romundstad, Luis, Kluzik, Anna, Zatorski, Paweł, Drygalski, Tomasz, Klimkiewicz, Jakub, Solek-pastuszka, Joanna, Onichimowski, Dariusz, Czuczwar, Miroslaw, Gawda, Ryszard, Stefaniak, Jan, Stefanska-Wronka, Karina, Zabul, Ewa, Oliveira, Ana Isabel Pinho, Assis, Rui, de Lurdes Campos Santos, Maria, Santos, Henrique, Cardoso, Filipe Sousa, Gordinho, André, Banzo, Maria José Arche, Zalba-Etayo, Begoña, Cubero, Patricia Patricia, Priego, Jesús, Gomà, Gemma, Tomasa-Irriguible, Teresa Maria, Sancho, Susana, Ferreira, Aida Fernández, Vázquez, Eric Mayor, Mira, Ángela Prado, Ibarz, Mercedes, Iglesias, David, Arias-Rivera, Susana, Frutos-Vivar, Fernando, Lopez-Cuenca, Sonia, Aldecoa, Cesar, Perez-Torres, David, Canas-Perez, Isabel, Tamayo-Lomas, Luis, Diaz-Rodriguez, Cristina, de Gopegui, Pablo Ruiz, Ben-Hamouda, Nawfel, Roberti, Andrea, Fleury, Yvan, Abidi, Nour, Chau, Ivan, Dullenkopf, Alexander, Pugh, Richard, Smuts, Sara, COVIP study group, [missing], Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), COVIP study group, Eller, P., Joannidis, M., Mesotten, D., Reper, P., Oeyen, S., Swinnen, W., Serck, N., Dewaele, E., Brix, H., Brushoej, J., Kumar, P., Nedergaard, H.K., Balleby, I.R., Bundesen, C., Hansen, M.A., Uhrenholt, S., Bundgaard, H., Fjølner, J., Gooch, J., Cagova, L., Potter, E., Reay, M., Davey, M., Abusayed, M.A., Humphreys, S., Galbois, A., Guidet, B., Charron, C., Berlemont, C.H., Besch, G., Rigaud, J.P., Maizel, J., Djibré, M., Burtin, P., Garcon, P., Nseir, S., Valette, X., Alexandru, N., Marin, N., Vaissiere, M., Plantefeve, G., Vanderlinden, T., Jurcisin, I., Megarbane, B., Chousterman, B.G., Dépret, F., Garnier, M., Besset, S., Oziel, J., Ferre, A., Dauger, S., Dumas, G., Goncalves, B., Vettoretti, L., Thevenin, D., Schaller, S., Kurt, M., Faltlhauser, A., Meyer, C., Milovanovic, M., Lutz, M., Shala, G., Haake, H., Randerath, W., Kunstein, A., Meybohm, P., Steiner, S., Barth, E., Poerner, T., Simon, P., Lorenz, M., Dindane, Z., Kuhn, K.F., Welte, M., Voigt, I., Kabitz, H.J., Wollborn, J., Goebel, U., Stoll, S.E., Kindgen-Milles, D., Dubler, S., Jung, C., Fuest, K., Schuster, M., Papadogoulas, A., Mulita, F., Rovina, N., Aidoni, Z., Chrisanthopoulou, E., Kondili, E., Andrianopoulos, I., Groenendijk, M., Evers, M., van Lelyveld-Haas, L., Meynaar, I., Cornet, A.D., Zegers, M., Dieperink, W., De Lange, D.W., Dormans, T., Hahn, M., Sjøbøe, B., Strietzel, H.F., Olasveengen, T., Romundstad, L., Andersen, F.H., Kluzik, A., Zatorski, P., Drygalski, T., Szczeklik, W., Klimkiewicz, J., Solek-Pastuszka, J., Onichimowski, D., Czuczwar, M., Gawda, R., Stefaniak, J., Stefanska-Wronka, K., Zabul, E., Oliveira, AIP, Assis, R., de Lurdes Campos Santos, M., Santos, H., Cardoso, F.S., Gordinho, A., Banzo, MJA, Zalba-Etayo, B., Cubero, P.P., Priego, J., Gomà, G., Tomasa-Irriguible, T.M., Sancho, S., Ferreira, A.F., Vázquez, E.M., Mira, Á.P., Ibarz, M., Iglesias, D., Arias-Rivera, S., Frutos-Vivar, F., Lopez-Cuenca, S., Aldecoa, C., Perez-Torres, D., Canas-Perez, I., Tamayo-Lomas, L., Diaz-Rodriguez, C., de Gopegui, P.R., Ben-Hamouda, N., Roberti, A., Fleury, Y., Abidi, N., Schefold, J.C., Chau, I., Dullenkopf, A., Pugh, R., and Smuts, S.

Subjects
IMPACT, MORTALITY, ICU, Medicine and Health Sciences, ILL ELDERLY-PATIENTS, 610 Medicine & health, ddc:610, Critical Care and Intensive Care Medicine, 610 Medizin und Gesundheit, FRAILTY, human activities, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract

Open Access funding enabled and organized by Projekt DEAL. This study was endorsed by the ESICM. Free support for running the electronic database and was granted from the dep. of Epidemiology, University of Aarhus, Denmark. Bruno et al. Annals of Intensive Care (2022) 12:26 Page 10 of 11 The support of the study in France by a grant from Fondation Assistance Publique-Hôpitaux de Paris pour la recherche is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon Programme call H2020-INFRAEOSC-05-2018-2019, grant agreement number 831644. This work was supported by the Collaborative Research Center SFB 1116 (German Research Foundation, DFG) and by the Forschungskommission of the Medical Faculty of the Heinrich-Heine-University Düsseldorf and No. 2020–21 to RRB for a Clinician Scientist Track. No (industry) sponsorship has been received for this investigator-initiated study. PURPOSE: Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities of Daily Living (ADL) with the outcome in this vulnerable patient group. METHODS: The COVIP study is a prospective international observational study that recruited ICU patients ≥ 70 years admitted with COVID-19 (NCT04321265). Several parameters including ADL (ADL; 0 = disability, 6 = no disability), Clinical Frailty Scale (CFS), SOFA score, intensive care treatment, ICU- and 3-month survival were recorded. A mixed-effects Weibull proportional hazard regression analyses for 3-month mortality adjusted for multiple confounders. RESULTS: This pre-specified analysis included 2359 patients with a documented ADL and CFS. Most patients evidenced independence in their daily living before hospital admission (80% with ADL = 6). Patients with no frailty and no disability showed the lowest, patients with frailty (CFS ≥ 5) and disability (ADL

Published
2022
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27. Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study

Author

Polok, Kamil, Fronczek, Jakub, Artigas, Antonio, Flaatten, Hans, Guidet, Bertrand, De Lange, Dylan W., Fjølner, Jesper, Leaver, Susannah, Beil, Michael, Sviri, Sigal, Bruno, Raphael Romano, Wernly, Bernhard, Bollen Pinto, Bernardo, Schefold, Joerg C., Studzińska, Dorota, Joannidis, Michael, Oeyen, Sandra, Marsh, Brian, Andersen, Finn H., Moreno, Rui, Cecconi, Maurizio, Jung, Christian, Szczeklik, Wojciech, Eller, Philipp, Mesotten, Dieter, Reper, Pascal, Swinnen, Walter, Brix, Helene, Brushoej, Jens, Villefrance, Maja, Nedergaard, Helene Korvenius, Bjerregaard, Anders Thais, Balleby, Ida Riise, Andersen, Kasper, Hansen, Maria Aagaard, Uhrenholt, Stine, Bundgaard, Helle, Hussein, Aliae A. R. Mohamed, Salah, Rehab, Ali, Yasmin Khairy NasrEldin Mohamed, Wassim, Kyrillos, Elgazzar, Yumna A., Tharwat, Samar, Azzam, Ahmed Y., habib, Ayman abdelmawgoad, Abosheaishaa, Hazem Maarouf, Azab, Mohammed A., Galbois, Arnaud, Charron, Cyril, Guerot, Emmanuel, Besch, Guillaume, Rigaud, Jean-Philippe, Maizel, Julien, Djibré, Michel, Burtin, Philippe, Garcon, Pierre, Nseir, Saad, Valette, Xavier, Alexandru, Nica, Marin, Nathalie, Vaissiere, Marie, Plantefeve, Gaëtan, Vanderlinden, Thierry, Jurcisin, Igor, Megarbane, Buno, Caillard, Anais, Valent, Arnaud, Garnier, Marc, Besset, Sebastien, Oziel, Johanna, RAPHALEN, Jean-herlé, Dauger, Stéphane, Dumas, Guillaume, Goncalves, Bruno, Piton, Gaël, Barth, Eberhard, Goebel, Ulrich, Kunstein, Anselm, Schuster, Michael, Welte, Martin, Lutz, Matthias, Meybohm, Patrick, Steiner, Stephan, Poerner, Tudor, Haake, Hendrik, Schaller, Stefan, Kindgen-Milles, Detlef, Meyer, Christian, Kurt, Muhammed, Kuhn, Karl Friedrich, Randerath, Winfried, Wollborn, Jakob, Dindane, Zouhir, Kabitz, Hans-Joachim, Voigt, Ingo, Shala, Gonxhe, Faltlhauser, Andreas, Rovina, Nikoletta, Aidoni, Zoi, Chrisanthopoulou, Evangelia, Papadogoulas, Antonios, Gurjar, Mohan, Mahmoodpoor, Ata, Ahmed, Abdullah khudhur, Elsaka, Ahmed, Comellini, Vittoria, Rabha, Ahmed, Ahmed, Hazem, Namendys-Silva, Silvio A., Ghannam, Abdelilah, Groenendijk, Martijn, Zegers, Marieke, de Lange, Dylan, Cornet, Alex, Evers, Mirjam, Haas, Lenneke, Dormans, Tom, Dieperink, Willem, Romundstad, Luis, Sjøbø, Britt, Strietzel, Hans Frank, Olasveengen, Theresa, Hahn, Michael, Czuczwar, Miroslaw, Gawda, Ryszard, Klimkiewicz, Jakub, de Lurdes Campos Santos, Maria, Gordinho, André, Santos, Henrique, Assis, Rui, Oliveira, Ana Isabel Pinho, Badawy, Mohamed Raafat, Perez-Torres, David, Gomà, Gemma, Villamayor, Mercedes Ibarz, Mira, Angela Prado, Cubero, Patricia Jimeno, Rivera, Susana Arias, Tomasa, Teresa, Iglesias, David, Vázquez, Eric Mayor, Aldecoa, Cesar, Ferreira, Aida Fernández, Zalba-Etayo, Begoña, Canas-Perez, Isabel, Tamayo-Lomas, Luis, Diaz-Rodriguez, Cristina, Sancho, Susana, Priego, Jesús, Abualqumboz, Enas M. Y., Hilles, Momin Majed Yousuf, Saleh, Mahmoud, Ben-HAmouda, Nawfel, Roberti, Andrea, Dullenkopf, Alexander, Fleury, Yvan, Al-Sadawi, Mohammed, COVIP Study Group, [missing], and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Male, Noninvasive Ventilation, Frailty, COVID-19, 610 Medicine & health, Critical Care and Intensive Care Medicine, Noninvasive Ventilation/adverse effects, Respiration, Artificial, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Cohort Studies, Intensive Care Units, Respiratory Insufficiency/therapy, Elderly, Medicine and Health Sciences, Humans, Intensive care unit, Female, Prospective Studies, 610 Medizin und Gesundheit, Respiratory Insufficiency, Noninvasive ventilation, Pandemics, COVID-19/therapy, Aged
Abstract

Background Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic. We aimed to evaluate the use of NIV in Europe and factors associated with outcomes of patients treated with NIV. Methods This is a substudy of COVIP study—an international prospective observational study enrolling patients aged ≥ 70 years with confirmed COVID-19 treated in ICU. We enrolled patients in 156 ICUs across 15 European countries between March 2020 and April 2021.The primary endpoint was 30-day mortality. Results Cohort included 3074 patients, most of whom were male (2197/3074, 71.4%) at the mean age of 75.7 years (SD 4.6). NIV frequency was 25.7% and varied from 1.1 to 62.0% between participating countries. Primary NIV failure, defined as need for endotracheal intubation or death within 30 days since ICU admission, occurred in 470/629 (74.7%) of patients. Factors associated with increased NIV failure risk were higher Sequential Organ Failure Assessment (SOFA) score (OR 3.73, 95% CI 2.36–5.90) and Clinical Frailty Scale (CFS) on admission (OR 1.46, 95% CI 1.06–2.00). Patients initially treated with NIV (n = 630) lived for 1.36 fewer days (95% CI − 2.27 to − 0.46 days) compared to primary IMV group (n = 1876). Conclusions Frequency of NIV use varies across European countries. Higher severity of illness and more severe frailty were associated with a risk of NIV failure among critically ill older adults with COVID-19. Primary IMV was associated with better outcomes than primary NIV. Clinical Trial RegistrationNCT04321265, registered 19 March 2020, https://clinicaltrials.gov.

Published
2022

28. State-of-the-Art Opinion Article on Ventilator-Induced Diaphragm Dysfunction: Update on Diagnosis, Clinical Course, and Future Treatment Options.

Author

Spiesshoefer, Jens, Kersten, Alexander, Enriquez Geppert, Jonathan, Regmi, Binaya, Senol, Mehdi, Kabitz, Hans Joachim, and Dreher, Michael

Subjects
INTENSIVE care units, MECHANICAL ventilators, CONVALESCENCE, DIAPHRAGM (Anatomy), ARTIFICIAL respiration, ELECTRIC stimulation, MUSCLE strength, ELECTROMYOGRAPHY
Abstract

Evidence from both animal and human studies now supports the development of ventilator-induced diaphragm dysfunction (VIDD) starting as early as 24 h after initiation of mechanical ventilation in the intensive care unit (ICU). However, although the concept of VIDD is now widely accepted, there remain several unanswered questions regarding its pathophysiology, rate of development, and (potentially) recovery after mechanical ventilation.This state-of-the-art opinion article briefly explains VIDD and provides an update on its clinical and prognostic relevance. It then focusses on state-of-the-art diagnostic approaches to determine diaphragm function, strength, and control (neural and peripheral), highlights knowledge gaps relevant to VIDD, and discusses the use of diaphragm pacing for VIDD prevention. It is suggested that future research projects in mechanically ventilated patients would ideally use both cortical and cervical phrenic nerve stimulation studies over time (including also diaphragm electromyography) as the gold standard techniques. This approach has not yet been utilized in a longitudinally designed study in the ICU. Application of these gold standard techniques would allow better understanding of the true pathophysiology and rate of development of VIDD. Notably, these techniques would be superior to diaphragm ultrasound, which yields surrogate markers of diaphragm function only without any direct measure of diaphragm strength or control. It is also suggested that such translational research would further advance understanding of diaphragm pacing as a very promising treatment option for VIDD. [ABSTRACT FROM AUTHOR]

Published
2023
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30. COMPERA 2.0: a refined four-stratum risk assessment model for pulmonary arterial hypertension

Author

Hoeper, Marius M., primary, Pausch, Christine, additional, Olsson, Karen M., additional, Huscher, Doerte, additional, Pittrow, David, additional, Grünig, Ekkehard, additional, Staehler, Gerd, additional, Vizza, Carmine Dario, additional, Gall, Henning, additional, Distler, Oliver, additional, Opitz, Christian, additional, Gibbs, J. Simon R., additional, Delcroix, Marion, additional, Ghofrani, H. Ardeschir, additional, Park, Da-Hee, additional, Ewert, Ralf, additional, Kaemmerer, Harald, additional, Kabitz, Hans-Joachim, additional, Skowasch, Dirk, additional, Behr, Juergen, additional, Milger, Katrin, additional, Halank, Michael, additional, Wilkens, Heinrike, additional, Seyfarth, Hans-Jürgen, additional, Held, Matthias, additional, Dumitrescu, Daniel, additional, Tsangaris, Iraklis, additional, Vonk-Noordegraaf, Anton, additional, Ulrich, Silvia, additional, Klose, Hans, additional, Claussen, Martin, additional, Lange, Tobias J., additional, and Rosenkranz, Stephan, additional

Published
2021
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32. Temporal trends in pulmonary arterial hypertension: results from the COMPERA registry

Author

Hoeper, Marius M., primary, Pausch, Christine, additional, Grünig, Ekkehard, additional, Staehler, Gerd, additional, Huscher, Doerte, additional, Pittrow, David, additional, Olsson, Karen M., additional, Vizza, Carmine Dario, additional, Gall, Henning, additional, Distler, Oliver, additional, Opitz, Christian, additional, Gibbs, J. Simon R., additional, Delcroix, Marion, additional, Ghofrani, H. Ardeschir, additional, Rosenkranz, Stephan, additional, Park, Da-Hee, additional, Ewert, Ralf, additional, Kaemmerer, Harald, additional, Lange, Tobias J., additional, Kabitz, Hans-Joachim, additional, Skowasch, Dirk, additional, Skride, Andris, additional, Claussen, Martin, additional, Behr, Juergen, additional, Milger, Katrin, additional, Halank, Michael, additional, Wilkens, Heinrike, additional, Seyfarth, Hans-Jürgen, additional, Held, Matthias, additional, Dumitrescu, Daniel, additional, Tsangaris, Iraklis, additional, Vonk-Noordegraaf, Anton, additional, Ulrich, Silvia, additional, and Klose, Hans, additional

Published
2021
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34. Outcomes of patients with progressive fibrosing interstitial lung disease (PF-ILD) – data from a prospective ILD registry

Author

Kreuter, Michael, primary, Kabitz, Hans-Joachim, additional, Hagmeyer, Lars, additional, Hammerl, Peter, additional, Esselmann, Albert, additional, Wiederhold, Conrad, additional, Skowasch, Dirk, additional, Stolpe, Christoph, additional, Joest, Marcus, additional, Veitshans, Stefan, additional, Höffgen, Marc, additional, Maqhuzu, Phillen, additional, Schwarzkopf, Larisa, additional, Hellmann, Andreas, additional, Pfeifer, Michael, additional, Behr, Jürgen, additional, Karpavicius, Rainer, additional, Günther, Andreas, additional, Herth, Felix J. F., additional, and Markart, Philipp, additional

Published
2021
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35. The Combination of Exercise and Respiratory Training Improves Respiratory Muscle Function in Pulmonary Hypertension

Author

Kabitz, Hans-Joachim, Bremer, Hinrich-Cordt, Schwoerer, Anja, Sonntag, Florian, Walterspacher, Stephan, Walker, David Johannes, Ehlken, Nicola, Staehler, Gerd, Windisch, Wolfram, and Grünig, Ekkehard

Subjects
Pulmonary hypertension -- Research -- Care and treatment -- Patient outcomes -- Development and progression, Exercise -- Research -- Health aspects, Health
Abstract

Purpose Increased dyspnea and reduced exercise capacity in pulmonary arterial hypertension (PAH) can be partly attributed to impaired respiratory muscle function. This prospective study was designed to assess the impact of exercise and respiratory training on respiratory muscle strength and 6-min walking distance (6MWD) in PAH patients. Methods Patients with invasively confirmed PAH underwent 3 weeks of in-hospital exercise and respiratory training, which was continued at home for another 12 weeks. Medication remained constant during the study period. Blinded observers assessed efficacy parameters at baseline (I) and after 3 (II) and 15 weeks (III). Respiratory muscle function was assessed by twitch mouth pressure (TwPmo) during nonvolitional supramaximal magnetic phrenic nerve stimulation. Results Seven PAH patients (4 women; mean pulmonary artery pressure 45 ± 11 mmHg, median WHO functional class 3.1 ± 0.4, idiopathic/associated PAH n = 5/2) were included. The training program was feasible and well tolerated by all patients with excellent compliance. TwPmo was I: 0.86 ± 0.37 kPa, II: 1.04 ± 0.29 kPa, and III: 1.27 ± 0.44 kPa, respectively. 6MWD was I: 417 ± 51 m, II: 509 ± 39 m, and III: 498 ± 39 m, respectively. Both TwPmo (+0.41 ± 0.34 kPa, +56 ± 39 %) and 6MWD (+81 ± 30 m, +20 ± 9 %) increased significantly in the period between baseline and the final assessment (pairwise comparison: p = 0.012/ Conclusions Exercise and respiratory training as an adjunct to medical therapy may be effective in patients with PAH to improve respiratory muscle strength and exercise capacity. Future, randomized, controlled trials should be carried out to further investigate these findings., Author(s): Hans-Joachim Kabitz[sup.1] , Hinrich-Cordt Bremer[sup.2] , Anja Schwoerer[sup.1] , Florian Sonntag[sup.1] , Stephan Walterspacher[sup.1] , David Johannes Walker[sup.1] , Nicola Ehlken[sup.3] , Gerd Staehler[sup.4] , Wolfram Windisch[sup.5] , Ekkehard [...]

Published
2014
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36. Bronchoscopic performance of bronchoalveolar lavage in germany – a call for standardization

Author

Hetzel, Juergen, Kreuter, Michael, Kähler, Christian M., Kabitz, Hans-Joachim, Gschwendtner, Andreas, Eberhardt, Ralf, Costabel, Ulrich, and Darwiche, Kaid

Subjects
interstitial lung disease, Original Article: Clinical Research, Bronchoscopy, Medizin, bronchoalveolar lavage, BAL survey
Abstract

Background: Bronchoalveolar lavage (BAL) is a widely used clinical tool in diagnosing interstitial lung diseases. Although there are recommendations and guidelines, the procedure is not completely standardized. Varying approaches likely influence the conclusiveness of BAL data and may be one reason for the divergent judgement of their value between different centers. Objectives: To evaluate how BAL is performed in Germany using an electronically based survey. Methods: We conducted a cross-sectional online survey among all members of the German Respiratory Society. Results: 608 members responded to the survey and of these 500 perform lavages. Most bronchoscopists (344/500) do not use a tube and have no anesthesiologist present during the procedure (405/500). Propofol is used by 76.8% and midazolam by 67.9% (n = 405), often in combination. A major difference was noted regarding the total volume of instillation. Many respondents use a predefined fixed amount of instilled volume (202/500), whereas an almost equal number use variable volumes based on the recovery (196/500). The minimum recovery volume predefined by 217/499 ranged from 3-150 ml (median 30 ml; mean 42.2 ± 55.1 ml). Most respondents did not transport their samples in special medium (61.5%) or on ice (72.8%). The average time between recovery and arrival at the lab was 115.6±267.0 min (n = 323). Conclusion: This study shows the broad spectrum of variations in the performance of BAL in Germany, which could have a negative effect on the method’s clinical value. There is a need for training and standardization of BAL performance.

Published
2021

37. Additional file 1 of Surface EMG-based quantification of inspiratory effort: a quantitative comparison with Pes

Author

Gra��hoff, Jan, Petersen, Eike, Farquharson, Franziska, Kustermann, Max, Kabitz, Hans-Joachim, Rostalski, Philipp, and Walterspacher, Stephan

Abstract

Additional file 1. Signal processing details: filtering of esophageal and gastric pressures, determination of chest wall elastance, automatic detection of efforts and sEMG offset correction.

Published
2021
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38. Temporal trends in pulmonary arterial hypertension: Results from the COMPERA registry

Author

Hoeper, Marius M. Pausch, Christine Grünig, Ekkehard Staehler, Gerd Huscher, Doerte Pittrow, David Olsson, Karen M. Vizza, Carmine Dario Gall, Henning Distler, Oliver Opitz, Christian Gibbs, J. Simon R. Delcroix, Marion Ghofrani, H. Ardeschir Rosenkranz, Stephan Park, Da-Hee Ewert, Ralf Kaemmerer, Harald Lange, Tobias J. Kabitz, Hans-Joachim Skowasch, Dirk Skride, Andris Claussen, Martin Behr, Juergen Milger, Katrin Halank, Michael Wilkens, Heinrike Seyfarth, Hans-Jürgen Held, Matthias Dumitrescu, Daniel Tsangaris, Iraklis Vonk-Noordegraaf, Anton Ulrich, Silvia Klose, Hans

Abstract

BACKGROUND: Since 2015, the European pulmonary hypertension guidelines recommend the use of combination therapy in most patients with pulmonary arterial hypertension (PAH). However, it is unclear to what extend this treatment strategy is adopted in clinical practice and if it is associated with improved long-term survival. METHODS: We analysed data from COMPERA, a large European pulmonary hypertension registry, to assess temporal trends in the use of combination therapy and survival of patients with newly diagnosed PAH between 2010 and 2019. For survival analyses, we look at annualized data and at cumulated data comparing the periods 2010-2014 and 2015-2019. RESULTS: A total of 2,531 patients were included. The use of early combination therapy (within 3 months after diagnosis) increased from 10.0\% in patients diagnosed with PAH in 2010 to 25.0\% in patients diagnosed with PAH in 2019. The proportion of patients receiving combination therapy 1 year after diagnosis increased from 27.7\% to 46.3\%. When comparing the 2010-2014 and 2015-2019 periods, 1-year survival estimates were similar (89.0\% [95\% CI, 87.2\%, 90.9\%] and 90.8\% [95\% CI, 89.3\%, 92.4\%]), respectively, whereas there was a slight but non-significant improvement in 3-year survival estimates (67.8\% [95\% CI, 65.0\%, 70.8\%] and 70.5\% [95\% CI, 67.8\%, 73.4\%]), respectively. CONCLUSIONS: The use of combination therapy increased from 2010 to 2019, but most patients still received monotherapy. Survival rates at 1 year after diagnosis did not change over time. Future studies need to determine if the observed trend suggesting improved 3-year survival rates can be confirmed.

Published
2021

40. The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study

Author

Jung, Christian, Flaatten, Hans, Fjølner, Jesper, Bruno, Raphael Romano, Wernly, Bernhard, Artigas, Antonio, Bollen Pinto, Bernardo, Schefold, Joerg, Wolff, Georg, Kelm, Malte, Beil, Michael, Sviri, Sigal, van Heerden, Peter Vernon, Szczeklik, Wojciech, Czuczwar, Miroslaw, Elhadi, Muhammed, Joannidis, Michael, Oeyen, Sandra, Zafeiridis, Tilemachos, Marsh, Brian, Andersen, Finn, Moreno, Rui, Cecconi, Maurizio, Leaver, Susannah, Boumendil, Ariane, de Lange, Dylan, Guidet, Bertrand, Abosheaishaa, Hazem Maarouf, Abualqumboz, Enas, Ahmed, Abdullah Khudhur, Ahmed, Hazem, Aidoni, Zoi, Aldecoa, Cesar, Alexandru, Nica, Ali, Yasmin Khairy Nasreldin Mohamed, Al-Sadawi, Mohammed, Andersen, Kasper, Assis, Rui, Azab, Mohammed, Azzam, Ahmed, Badawy, Mohamed Raafat, Balleby, Ida Riise, Barth, Eberhard, Ben-Hamouda, Nawfel, Besch, Guillaume, Besset, Sebastien, Bjerregaard, Anders Thais, Brix, Helene, Brushoej, Jens, Bundgaard, Helle, Burtin, Philippe, Caillard, Anais, Canas-Perez, Isabel, Charron, Cyril, Chrisanthopoulou, Evangelia, Comellini, Vittoria, Cornet, Alex, Cubero, Patricia Jimeno, Dauger, Stéphane, Diaz-Rodriguez, Cristina, Dieperink, Willem, Dindane, Zouhir, Djibré, Michel, Dormans, Tom, Dullenkopf, Alexander, Dumas, Guillaume, Elgazzar, Yumna, Eller, Philipp, Elsaka, Ahmed, Evers, Mirjam, Faltlhauser, Andreas, Ferreira, Aida Fernández, Fleury, Yvan, Galbois, Arnaud, Garcon, Pierre, Garnier, Marc, Gawda, Ryszard, Ghannam, Abdelilah, Goebel, Ulrich, Gomà, Gemma, Goncalves, Bruno, Gordinho, André, Groenendijk, Martijn, Guerot, Emmanuel, Gurjar, Mohan, Haake, Hendrik, Haas, Lenneke, Habib, Ayman Abdelmawgoad, Hahn, Michael, Hansen, Maria Aagaard, Hilles, Momin Majed Yousuf, Hussein, Aliae, Iglesias, David, Jurcisin, Igor, Kabitz, Hans-Joachim, Kindgen-Milles, Detlef, Klimkiewicz, Jakub, Kuhn, Karl Friedrich, Kunstein, Anselm, Kurt, Muhammed, Lutz, Matthias, Mahmoodpoor, Ata, Maizel, Julien, Marin, Nathalie, Megarbane, Buno, Mesotten, Dieter, Meybohm, Patrick, Meyer, Christian, Mira, Angela Prado, Namendys-Silva, Silvio, Nedergaard, Helene Korvenius, Nseir, Saad, Olasveengen, Theresa, Oliveira, Ana Isabel Pinho, Oziel, Johanna, Papadogoulas, Antonios, Perez-Torres, David, Piton, Gaël, Plantefeve, Gaëtan, Poerner, Tudor, Priego, Jesús, Rabha, Ahmed, Randerath, Winfried, Raphaelen, Jean-Herlé, Reper, Pascal, Rigaud, Jean-Philippe, Rivera, Susana Arias, Roberti, Andrea, Romundstad, Luis, Rovina, Nikoletta, Salah, Rehab, Saleh, Mahmoud, Sancho, Susana, de Lurdes Campos Santos, Maria, Santos, Henrique, Schaller, Stefan, Schuster, Michael, Shala, Gonxhe, Sjøbø, Britt, Steiner, Stephan, Strietzel, Hans Frank, Swinnen, Walter, Tamayo-Lomas, Luis, Tharwat, Samar, Tomasa, Teresa, Uhrenholt, Stine, Vaissiere, Marie, Valent, Arnaud, Valette, Xavier, Vanderlinden, Thierry, Vázquez, Eric Mayor, Villamayor, Mercedes Ibarz, Villefrance, Maja, Voigt, Ingo, Wassim, Kyrillos, Welte, Martin, Wollborn, Jakob, Zalba-Etayo, Begoña, Zegers, Marieke, Mégarbane, Bruno, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and COVIP study group

Subjects
[SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract

Auteurs : COVIP study group; International audience; Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients. Methods A prospective multicentre study of COVID-19 patients ≥ 70 years admitted to intensive care in 138 ICUs from 28 countries was conducted. The primary endpoint was 30-day mortality. Frailty was assessed using the clinical frailty scale. Additionally, comorbidities, management strategies and treatment limitations were recorded. Results The study included 1346 patients (28% female) with a median age of 75 years (IQR 72–78, range 70–96), 16.3% were older than 80 years, and 21% of the patients were frail. The overall survival at 30 days was 59% (95% CI 56–62), with 66% (63–69) in fit, 53% (47–61) in vulnerable and 41% (35–47) in frail patients ( p

Published
2021

41. COMPERA 2.0: A refined 4-strata risk assessment model for pulmonary arterial hypertension

Author

Hoeper, Marius M. Pausch, Christine Olsson, Karen M. Huscher, Doerte Pittrow, David Grünig, Ekkehard Staehler, Gerd Vizza, Carmine Dario Gall, Henning Distler, Oliver Opitz, Christian Gibbs, J. Simon R. Delcroix, Marion Ghofrani, H. Ardeschir Park, Da-Hee Ewert, Ralf Kaemmerer, Harald Kabitz, Hans-Joachim Skowasch, Dirk Behr, Juergen Milger, Katrin Halank, Michael Wilkens, Heinrike Seyfarth, Hans-Jürgen Held, Matthias Dumitrescu, Daniel Tsangaris, Iraklis Vonk-Noordegraaf, Anton Ulrich, Silvia Klose, Hans Claussen, Martin Lange, Tobias J. Rosenkranz, Stephan

Abstract

BACKGROUND: Risk stratification plays an essential role in the management of patients with pulmonary arterial hypertension (PAH). The current European guidelines propose a 3-strata model to categorise risk as low, intermediate, or high, based on the expected 1-year mortality. However, with this model, most patients are categorised as intermediate risk. We investigated a modified approach based on 4 risk categories with intermediate risk subdivided into intermediate-low and intermediate-high risk. METHODS: We analysed data from COMPERA, a European pulmonary hypertension registry, and calculated risk at diagnosis and first follow-up based on functional class (FC), 6 min walking distance (6 MWD) and serum levels of brain natriuretic peptide (BNP) or N-terminal fragment of pro-BNP (NT-proBNP), using refined cut-off values. Survival was assessed with Kaplan-Meier analyses, log-rank testing, and Cox proportional hazards models. RESULTS: Data from 1,655 patients with PAH were analysed. Using the 3-strata model, most patients were classified as intermediate risk (76.0\% at baseline and 63.9\% at first follow-up). The refined 4-strata risk model yielded a more nuanced separation and predicted long-term survival, especially at follow-up assessment. Changes in risk from baseline to follow-up were observed in 31.1\% of the patients with the 3-strata model and in 49.2\% with the 4-strata model. These changes, including those between the intermediate-low and intermediate-high strata, were associated with changes in long-term mortality risk. CONCLUSIONS: Modified risk stratification using a 4-strata model based on refined cut-off levels for FC, 6MWD and BNP/NT-proBNP was more sensitive to prognostically relevant changes in risk than the original 3-strata model.

Published
2021

42. Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients

Author

Bruno, Raphael Romano, Wernly, Bernhard, Flaatten, Hans, Artigas, Antonio, Bollen Pinto, Bernardo, Binnebössel, Stephan, Baldia, Philipp Heinrich, Kelm, Malte, Beil, Michael, Sigal, Sivri, van Heerden, Peter Vernon, Elhadi, Muhammed, Zafeiridis, Tilemachos, Arche Banzo, Maria José, Moreno, Rui, Boumendil, Ariane, De Lange, Dylan W., Eller, Philipp, Joannidis, Michael, Mesotten, Dieter, Reper, Pascal, Oeyen, Sandra, Swinnen, Walter, Serck, Nicolas, Dewaele, Elisabeth, Chapeta, Edwin, Brix, Helene, Brushoej, Jens, Kumar, Pritpal, Nedergaard, Helene Korvenius, Johnsen, Tim Koch, Bundesen, Camilla, Hansen, Maria Aagaard, Uhrenholt, Stine, Bundgaard, Helle, Fjølner, Jesper, Innes, Richard, Gooch, James, Cagova, Lenka, Potter, Elizabeth, Reay, Michael, Davey, Miriam, Abusayed, Mohammed Abdelshafy, Humphreys, Sally, Collins, Amy, Aujayeb, Avinash, Leaver, Susannah, Khaliq, Waqas, Habib, Ayman Abdelmawgoad, Azab, Mohammed A., Wassim, Kyrillos, Elgazzar, Yumna A., Salah, Rehab, Abosheaishaa, Hazem Maarouf, Hussein Mohamed, Aliae A. R., Azzam, Ahmed Y., Tharwat, Samar, Ali, Yasmin Khairy Nasreldin Mohamed, Elmandouh, Omar, Galal, Islam, Abu-Elfatth, Ahmed, Motawea, Karam, Elbahnasawy, Mohammad, Shehata, Mostafa, Elbahnasawy, Mohamed, Tayeb, Mostafa, Osman, Nermin, Abdel-Elsalam, Wafaa, Hussein, Aliae Mohamed, Aldhalia, Amer, Galbois, Arnaud, Guidet, Bertrand, Charron, Cyril, Berlemont, Caroline Hauw, Besch, Guillaume, Rigaud, Jean-Philippe, Maizel, Julien, Djibré, Michel, Burtin, Philippe, Garcon, Pierre, Nseir, Saad, Valette, Xavier, Alexandru, Nica, Marin, Nathalie, Vaissiere, Marie, Plantefeve, Gaëtan, Mentec, Hervé, Vanderlinden, Thierry, Jurcisin, Igor, Megarbane, Buno, Chousterman, Benjamin Glenn, Dépret, François, Garnier, Marc, Besset, Sebastien, Oziel, Johanna, Ferre, Alexis, Dauger, Stéphane, Dumas, Guillaume, Goncalves, Bruno, Vettoretti, Lucie, Thevenin, Didier, Schaller, Stefan, Kurt, Muhammed, Faltlhauser, Andreas, Meyer, Christian, Milovanovic, Milena, Lutz, Matthias, Shala, Gonxhe, Haake, Hendrik, Randerath, Winfried, Kunstein, Anselm, Meybohm, Patrick, Barth, Eberhard, Poerner, Tudor, Simon, Philipp, Lorenz, Marco, Dindane, Zouhir, Kuhn, Karl Friedrich, Welte, Martin, Voigt, Ingo, Kabitz, Hans-Joachim, Wollborn, Jakob, Goebel, Ulrich, Stoll, Sandra Emily, Kindgen-Milles, Detlef, Dubler, Simon, Jung, Christian, Fuest, Kristina, Schuster, Michael, Steiner, Stephan, Papadogoulas, Antonios, Mulita, Francesk, Rovina, Nikoletta, Aidoni, Zoi, Chrisanthopoulou, Evangelia, Kondili, Eumorfia, Andrianopoulos, Ioannis, Gurjar, Mohan, Mahmoodpoor, Ata, Hussein, Rand, Al-Juaifari, Maytham Aqeel, Karantenachy, Abdullah Khudhur Ahmed, Sviri, Sigal, Elsaka, Ahmed, Marsh, Brian, Comellini, Vittoria, Al-Ali, Farah, Almani, Sari, Khamees, Almu' Atasim, Al-Shami, Khayry, El Din, Ibrahim Salah, Abubaker, Taha, Ahmed, Hazem, Rabha, Ahmed, Emhamed, Marwa, Abdeewi, Saedah, Abusalama, Abdurraouf, Alhadi, Abdulmueti, Huwaysh, Mohammed, Alghati, Esraa Abdalqader, Ghannam, Abdelilah, Namendys-Sylva, Silvio A., Groenendijk, Martijn, Evers, Mirjam, Van Lelyveld-Haas, Lenneke, Meynaar, Iwan, Cornet, Alexander Daniel, Zegers, Marieke, Dieperink, Willem, De Lange, Dylan, Dormans, Tom, Hahn, Michael, Sjøbøe, Britt, Strietzel, Hans Frank, Olasveengen, Theresa, Romundstad, Luis, Andersen, Finn H., Massoud, John George Grace, Khan, Aamir Ghafoor, Al-Qasrawi, Shahd, Amro, Sarah, Kluzik, Anna, Zatorski, Pawel, Drygalski, Tomasz, Szczeklik, Wojciech, Klimkiewicz, Jakub, Solek-Pastuszka, Joanna, Onichimowski, Dariusz, Czuczwar, Miroslaw, Gawda, Ryszard, Stefaniak, Jan, Stefanska-Wronka, Karina, Zabul, Ewa, Oliveira, Ana Isabel Pinho, Assis, Rui, De Lurdes Campos Santos, Maria, Santos, Henrique, Cardoso, Filipe Sousa, Gordinho, André, Grintescu, Ioana Marina, Tomescu, Dana, Badawy, Mohamed Raafat, José Arche Banzo, M., Zalba-Etayo, Begoña, Cubero, Patricia Jimeno, Priego, Jesús, Gomà, Gemma, Tomasa-Irriguible, Teresa Maria, Sancho, Susana, Ferreira, Aida Fernández, Vázquez, Eric Mayor, Mira, Ángela Prado, Ibarz, Mercedes, Iglesias, David, Arias-Rivera, Susana, Frutos-Vivar, Fernando, Lopez-Cuenca, Sonia, Aldecoa, Cesar, Perez-Torres, David, Canas-Perez, Isabel, Tamayo-Lomas, Luis, Diaz-Rodriguez, Cristina, De Gopegui, Pablo Ruiz, Saleh, Mahmoud, Hilles, Momin Majed Yousuf, Abualqumboz, Enas M. Y., Ben-Hamouda, Nawfel, Roberti, Andrea, Fleury, Yvan, Abidi, Nour, Schefold, Joerg C., Chau, Ivan, Dullenkopf, Alexander, Chaaban, Mohammad Karam, Shebani, Mohammed Mouaz, Hmaideh, Ahmad, Shaher, Aymen, Sahin, Ayca Sultan, Saracoglu, Kemal Tolga, Al-Sadawi, Mohammed, Pugh, Richard, Smuts, Sara, and Al-Saban, Rafat Ameen Mohammed

Subjects
Research, Intensive / Critical Care Medicine, Emergency Medicine, Anesthesiology, ddc
Published
2020

46. Heart Failure Results in Inspiratory Muscle Dysfunction Irrespective of Left Ventricular Ejection Fraction

Author

Spiesshoefer, Jens, primary, Henke, Carolin, additional, Kabitz, Hans Joachim, additional, Bengel, Philipp, additional, Schütt, Katharina, additional, Nofer, Jerzy-Roch, additional, Spieker, Maximilian, additional, Orwat, Stefan, additional, Diller, Gerhard Paul, additional, Strecker, Jan Kolia, additional, Giannoni, Alberto, additional, Dreher, Michael, additional, Randerath, Winfried Johannes, additional, Boentert, Matthias, additional, and Tuleta, Izabela, additional

Published
2020
Full Text
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47. Inspiratory muscle dysfunction and restrictive lung function impairment in congenital heart disease: Association with immune inflammatory response and exercise intolerance

Author

Spiesshoefer, Jens, primary, Orwat, Stefan, additional, Henke, Carolin, additional, Kabitz, Hans-Joachim, additional, Katsianos, Stratis, additional, Borrelli, Chiara, additional, Baumgartner, Helmut, additional, Nofer, Jerzy-Roch, additional, Spieker, Maximilian, additional, Bengel, Philipp, additional, Giannoni, Alberto, additional, Dreher, Michael, additional, Boentert, Matthias, additional, and Diller, Gerhard Paul, additional

Published
2020
Full Text
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48. Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry

Author

Hoeper, Marius M, Pausch, Christine, Grünig, Ekkehard, Klose, Hans, Staehler, Gerd, Huscher, Doerte, Pittrow, David, Olsson, Karen M, Vizza, Carmine Dario, Gall, Henning, Benjamin, Nicola, Distler, Oliver, Opitz, Christian, Gibbs, J Simon R, Delcroix, Marion, Ghofrani, H Ardeschir, Rosenkranz, Stephan, Ewert, Ralf, Kaemmerer, Harald, Lange, Tobias J, Kabitz, Hans-Joachim, Skowasch, Dirk, Skride, Andris, Jurevičienė, Elena, Paleviciute, Egle, Miliauskas, Skaidrius, Claussen, Martin, Behr, Juergen, Milger, Katrin, Halank, Michael, et al, University of Zurich, and Hoeper, Marius M

Subjects
2740 Pulmonary and Respiratory Medicine, 2747 Transplantation, 10051 Rheumatology Clinic and Institute of Physical Medicine, 610 Medicine & health, 10178 Clinic for Pneumology, 2705 Cardiology and Cardiovascular Medicine, 2746 Surgery
Published
2020
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