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220 results on '"Kadokura, Mitsutaka"'

5. Benefit of Adjuvant Chemotherapy for Patients Older Than 75 Years With Completely Resected p-Stage II-IIIA Non–Small-Cell Lung Cancer: A Retrospective Cohort Study Using Japanese Nationwide Real-World Data

Author

Adachi, Hiroyuki, Morohoshi, Takao, Shintani, Yasushi, Okami, Jiro, Ito, Hiroyuki, Ohtsuka, Takashi, Mori, Takeshi, Watanabe, Shun-ichi, Chida, Masayuki, Endo, Shunsuke, Nakanishi, Ryoichi, Kadokura, Mitsutaka, Suzuki, Hidemi, Miyaoka, Etsuo, Yoshino, Ichiro, and Date, Hiroshi

Published
2024
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8. Nationwide prospective registry database of patients with newly diagnosed untreated pleural mesothelioma in Japan

Author

Hasegawa, Seiki, primary, Shintani, Yasushi, additional, Takuwa, Teruhisa, additional, Aoe, Keisuke, additional, Kato, Katsuya, additional, Fujimoto, Nobukazu, additional, Hida, Yasuhiro, additional, Morise, Masahiro, additional, Moriya, Yasumitsu, additional, Morohoshi, Takao, additional, Suzuki, Hidemi, additional, Chida, Masayuki, additional, Endo, Shunsuke, additional, Kadokura, Mitsutaka, additional, Okumura, Meinoshin, additional, Hattori, Satoshi, additional, Date, Hiroshi, additional, and Yoshino, Ichiro, additional

Published
2023
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9. Benefit of adjuvant chemotherapy for patients older than 75 years with completely resected p-stage II–IIIA non-small cell lung cancer: A retrospective cohort study using Japanese nationwide real-world data

Author

Adachi, Hiroyuki, primary, Morohoshi, Takao, additional, Shintani, Yasushi, additional, Okami, Jiro, additional, Ito, Hiroyuki, additional, Ohtsuka, Takashi, additional, Mori, Takeshi, additional, Watanabe, Shun-ichi, additional, Chida, Masayuki, additional, Endo, Shunsuke, additional, Nakanishi, Ryoichi, additional, Kadokura, Mitsutaka, additional, Suzuki, Hidemi, additional, Miyaoka, Etsuo, additional, Yoshino, Ichiro, additional, and Date, Hiroshi, additional

Published
2023
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10. Nationwide prospective registry database of patients with newly diagnosed untreated pleural mesothelioma in Japan.

Author

Hasegawa, Seiki, Shintani, Yasushi, Takuwa, Teruhisa, Aoe, Keisuke, Kato, Katsuya, Fujimoto, Nobukazu, Hida, Yasuhiro, Morise, Masahiro, Moriya, Yasumitsu, Morohoshi, Takao, Suzuki, Hidemi, Chida, Masayuki, Endo, Shunsuke, Kadokura, Mitsutaka, Okumura, Meinoshin, Hattori, Satoshi, Date, Hiroshi, and Yoshino, Ichiro

Abstract

Due to the scarcity of large‐sized prospective databases, the Japanese Joint Committee for Lung Cancer Registry conducted a nationwide prospective registry for newly diagnosed and untreated pleural mesothelioma. All new cases diagnosed pathologically as any subtype of pleural mesothelioma in Japan during the period between April 1, 2017, to March 31, 2019, were included before treatment. Data on survival were collected in April 2021. The eligible 346 patients (285 men [82.3%]; 61 women [17.7%]; median age, 71.0 years [range, 44–88]) were included for analysis. Among these patients, 138 (39.9%) underwent surgery, 164 (47.4%) underwent non‐surgical therapy, and the remaining 44 (12.7%) underwent best supportive care. The median overall survival for all 346 patients was 19.0 months. Survival rates at 1, 2, and 3 years for all patients were, 62.8%, 42.3%, and 26.5%, respectively. Median overall survival was significantly different among patients undergoing surgery, non‐surgical treatment, and best supportive care (32.2 months vs. 14.0 months vs. 3.8 months, p < 0.001). The median overall survival of patients undergoing pleurectomy/decortication and extrapleural pneumonectomy was 41.8 months and 25.0 months, respectively. Macroscopic complete resection resulted in longer overall survival than R2 resection and partial pleurectomy/exploratory thoracotomy (41.8 months vs. 32.2 months vs. 16.8 months, p < 0.001). Tumor shape, maximum tumor thickness, and sum of three level thickness were significant prognostic factors. The data in the prospective database would serve as a valuable reference for clinical practice and further studies for pleural mesothelioma. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Is adjuvant chemotherapy for completely resected p-stage IA (>2 cm) and stage IB non-small-cell lung cancer beneficial for elderly patients? A large, retrospective cohort study based on real-world data from Japan.

Author

Adachi, Hiroyuki, Saito, Aya, Shintani, Yasushi, Okami, Jiro, Ito, Hiroyuki, Ohtsuka, Takashi, Mori, Takeshi, Watanabe, Shun-ichi, Chida, Masayuki, Endo, Shunsuke, Nakanishi, Ryoichi, Kadokura, Mitsutaka, Suzuki, Hidemi, Miyaoka, Etsuo, Yoshino, Ichiro, Date, Hiroshi, and Registry, Japanese Joint Committee of Lung Cancer

Published
2023
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14. Hazard Function Analysis of Recurrence in Patients with Curatively Resected Lung Cancer: Results from the Japanese Lung Cancer Registry in 2010

Author

Yamauchi, Yoshikane, primary, Kawamura, Masafumi, additional, Okami, Jiro, additional, Shintani, Yasushi, additional, Ito, Hiroyuki, additional, Ohtsuka, Takashi, additional, Toyooka, Shinichi, additional, Mori, Takeshi, additional, Watanabe, Shun-ichi, additional, Asamura, Hisao, additional, Chida, Masayuki, additional, Endo, Shunsuke, additional, Kadokura, Mitsutaka, additional, Nakanishi, Ryoichi, additional, Miyaoka, Etsuo, additional, Suzuki, Hidemi, additional, Yoshino, Ichiro, additional, and Date, Hiroshi, additional

Published
2022
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17. Preoperative renal dysfunction and long-term survival after surgery for non–small cell lung cancer

Author

Saito, Tomohito, primary, Murakawa, Tomohiro, additional, Shintani, Yasushi, additional, Okami, Jiro, additional, Miyaoka, Etsuo, additional, Yoshino, Ichiro, additional, Date, Hiroshi, additional, Ito, Hiroyuki, additional, Ohtsuka, Takashi, additional, Toyooka, Shinichi, additional, Mori, Takeshi, additional, Watanabe, Shun-ichi, additional, Asamura, Hisao, additional, Chida, Masayuki, additional, Endo, Shunsuke, additional, Kadokura, Mitsutaka, additional, and Nakanishi, Ryoichi, additional

Published
2022
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23. Limited resection for stage IA radiologically invasive lung cancer: a real-world nationwide database study.

Author

Soh, Junichi, Toyooka, Shinichi, Shintani, Yasushi, Okami, Jiro, Ito, Hiroyuki, Ohtsuka, Takashi, Mori, Takeshi, Watanabe, Shun-Ichi, Asamura, Hisao, Chida, Masayuki, Endo, Shunsuke, Nakanishi, Ryoichi, Kadokura, Mitsutaka, Suzuki, Hidemi, Miyaoka, Etsuo, Yoshino, Ichiro, Date, Hiroshi, and Registry, Japanese Joint Committee of Lung Cancer

Subjects
CANCER invasiveness, LUNG cancer, NON-small-cell lung carcinoma, PROPENSITY score matching, OVERALL survival
Abstract

Open in new tab Download slide OBJECTIVES Radiologically invasive non-small-cell lung cancer, defined as consolidation size to maximum tumour diameter ratio of over 0.5, is associated with pathological invasiveness and worse prognosis. However, there are no real-world, nationwide database studies on limited resections that consider radiological invasiveness. This study aimed to investigate the prognostic validity of limited resection, such as segmentectomy and wedge resection, in cStage IA (TNM 8th edition) radiologically invasive lung cancer. METHODS We conducted a retrospective analysis of patients who underwent complete resection according to the Japanese Joint Committee of Lung Cancer Registry Database. The relationship between surgical procedures and prognosis was examined using stratification by cT factor and radiological invasiveness. RESULTS Among the 5,692 patients enrolled, lobectomy, segmentectomy and wedge resection were performed in 4,323 (80.0%), 657 (11.5%) and 712 (12.5%) patients, respectively. Multivariable analysis with or without propensity score matching indicated that older age, poor performance status and wedge resection were significantly associated with worse prognosis and that patients who underwent segmentectomy showed an equivalent prognosis to those who underwent lobectomy. Subset analyses revealed that segmentectomy showed an equivalent prognosis to lobectomy in patients with cT1b or less, but not in those with cT1c, especially for non-pure radiological invasive cT1c; 5-year overall survival rates were 91.4% vs 90.4% in cT1b with non-pure radiological invasiveness and 80.0% vs 83.8% in cT1b with pure radiological invasiveness, respectively. CONCLUSIONS Segmentectomy can be an alternative to lobectomy in patients with radiologically invasive lung cancer with cT1b or less but not in those with cT1c. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Endoscopic Findings of Post-wedge Bronchoplastic Lobectomy

Author

KITAMI, Akihiko, SANO, Fumitoshi, OHASHI, Shinichi, HAYASHI, Shoko, SUZUKI, Kosuke, UEMATSU, Shugo, KAMIO, Yoshito, SUZUKI, Takashi, and KADOKURA, Mitsutaka

Subjects
respiratory system, respiratory tract diseases
Abstract

It is speculated that the advantage of wedge bronchoplastic lobectomy lies in the reduction in the incidence of major anastomotic complications. On the other hand, wedge bronchoscopic lobectomy can result in kinking at the anastomosis site. This study was performed to evaluate the operative outcomes and the postoperative endoscopic findings for wedge resection of the bronchus. From 2004 to 2012, nine patients underwent wedge bronchoplastic lobectomy for lung carcinoma. We evaluated the angles of the wedge and the distance of the preserved parts to the cut line of the bronchus (the so-called bronchial bridge). There were six right upper lobectomies, two middle and lower lobectomies, and one left lower lobectomy. Regarding bronchoscopic findings, five patients who underwent right upper lobectomy showed bulging into the bronchial lumen. There were no anastomotic strictures. Intraoperatively it was noted in these five patients that the bronchial bridge tended to be relatively long and/or the angle of the wedge resection tended to be relatively wide. To prevent bulging into the bronchial lumen after right upper wedge bronchoplastic lobectomy, bronchial wedge excisions should be shaped in order to reduce the length of the bronchial bridge.

Published
2015

39. Well-differentiated Papillary Mesothelioma of the Pleura Diagnosed by Video-Assisted Thoracic Surgical Pleural Biopsy: A Case Report

Author

TOMITA, Yuri, NONAKA, Makoto, HIMURO, Naoya, KATAOKA, Daisuke, NAKASHIMA, Masanao, HIROSE, Takashi, KUSHIMA, Miki, and KADOKURA, Mitsutaka

Subjects
respiratory system, respiratory tract diseases
Abstract

Well-differentiated papillary mesothelioma of the pleura (WDPM-P) is an extremely rare type of mesothelial tumor that is thought to be of low malignant potential. Herein, we report on a case of WDPM-P. A 74-year-old woman was admitted for evaluation of shortness of breath. Pleural effusion was observed in the right thorax. Computed tomography after chest drainage did not reveal any lung or pleural tumors. Abnormally high levels of hyaluronic acid were detected in the pleural effusion. Cytological examination of the effusion revealed Class V findings; however, it was difficult to distinguish mesothelioma from adenocarcinoma. Because immunological evaluation may have provided more information, video-assisted thoracic surgical pleural biopsy (VATS-PB) was performed. Biopsied frozen specimens were revealed to be mesothelioma, and so localized pleurectomy and partial resection of the diaphragm were performed. Pathological examination established a diagnosis of WDPM-P. Six years postoperatively, the patient is doing well. As demonstrated in the present case, combined VATS-PB and pathological studies are useful for the diagnosis of and determination of surgical indications for pleural malignancies.

Published
2013

41. Adherence and feasibility of 2 treatment schedules of S-1 as adjuvant chemotherapy for patients with completely resected advanced lung cancer: a multicenter randomized controlled trial

Author

Hata, Yoshinobu, primary, Kiribayashi, Takaharu, additional, Kishi, Kazuma, additional, Nagashima, Makoto, additional, Nakayama, Takefumi, additional, Ikeda, Shingo, additional, Kadokura, Mitsutaka, additional, Ozeki, Yuichi, additional, Otsuka, Hajime, additional, Murakami, Yoshitaka, additional, Takagi, Keigo, additional, and Iyoda, Akira, additional

Published
2017
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44. Thymidine phosphorylase affects clinical outcome following surgery and mRNA expression levels of four key enzymes for 5-fluorouracil metabolism in patients with stage I and II non-small cell lung cancer.

Author

Himuro, Naoya, Niiya, Yumiko, Minakata, Takao, Oshima, Yutaka, Kataoka, Daisuke, Yamamoto, Shigeru, Suzuki, Takashi, and Kadokura, Mitsutaka

Subjects
THYMIDINE phosphorylase, DIHYDROPYRIMIDINE dehydrogenase, THYMIDYLATE synthase
Abstract

The expression levels of thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT) may predict the clinical efficacy of 5-fluorouracil-based chemotherapy in patients with cancer. We herein investigated the differences in the mRNA levels of these enzymes in non-small-cell lung cancer (NSCLC) and evaluated their prognostic value for NSCLC treated by surgical resection. The intratumoral mRNA levels of TP, DPD, TS, and OPRT were quantified in 66 patients with pathological stage I and II NSCLC (adenocarcinoma or squamous cell carcinoma) following complete resection according to the Danenberg Tumor Profile method. The TP level was the only significant prognostic factor for disease-specific survival (DSS) following complete resection; the mean TP mRNA level differed significantly between the high and low mRNA expression groups. The DSS at 5 years was significantly higher in the low TP mRNA compared with that in the high TP mRNA expression group (83.4 vs. 58.6%, respectively; P=0.005). A Cox proportional hazards model revealed that pathological stage, sex, and TP expression were independent prognostic factors for DSS in patients with stage I and II NSCLC following complete resection. Thus, TP level may be used to monitor treatment efficacy and predict the outcome of NSCLC patients. [ABSTRACT FROM AUTHOR]

Published
2018
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