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6. Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis

Author

Higo, Yosuke, primary, Hisamatsu, Takashi, additional, Nakagawa, Yoshihisa, additional, Sawayama, Yuichi, additional, Yano, Yuichiro, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Watanabe, Yoshiyuki, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2024
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9. Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men

Author

Sekikawa, Akira, Mahajan, Hemant, Kadowaki, Sayaka, Hisamatsu, Takashi, Miyagawa, Naoko, Fujiyoshi, Akira, and Kadota, Aya

Subjects
Calcification (Physiology) -- Analysis, Atherosclerosis -- Development and progression -- Risk factors -- Analysis, Omega 3 fatty acids -- Analysis, Unsaturated fatty acids -- Analysis, Epidemiology -- Analysis, Medical schools -- Analysis, CAT scans, Clinical trials, Fatty acids, Tomography, Food/cooking/nutrition, Health
Abstract

Background/objectives: Clinical trials of eicosapentaenoic acid (EPA) among high-risk groups in Japan in which consumption of mairne-omega-3 fatty acids (OM3) is much higher than other countries showed slower progression of coronary atherosclerosis. We aimed to determine the cross-sectional associations of coronary artery calcification (CAC) and calcium density with OM3, EPA, and docosahexaenoic acid (DHA), two principal OM3, in the general population in Japan. Subjects/methods: The Shiga Epidemiological Study of Subclinical Atherosclerosis examined a population-based sample of 1074 men aged 40-79 in 2006-08 for computed tomography-measured CAC score (CCS), a well-established biomarker of coronary atherosclerosis, CAC density score (CDS), a potential marker of plaque stabilization, serum levels of OM3, and risk factors. Results: Prevalence of CCS > 0, [greater than or equal to] 100, and [greater than or equal to] 300 was 65.8%, 25.9%, and 12.9%, respectively; the mean (SD) OM3, EPA, and DHA were 10.1% (3.2), 3.2% (1.7), and 5.9% (1.6), respectively. Odds ratios (95% CI, p-value) of CCS 0, 100, and 300 in ordinal logistic regression associated with 1 SD increase of OM3, EPA, and DHA were 0.91 (0.81-1.03, p = 0.12), 0.99 (0.88-1.11, p = 0.87) and 0.84 (0.74-0.94, p = < 0.01), respectively. The inverse association of DHA with CCS remained significant in multivariate-adjusted model: odds ratio of 0.87 (0.77-0.99, p = 0.03). Blood levels of OM3, EPA, or DHA did not have any significant associations with CDS. Conclusions: DHA but not EPA had a significant inverse association with coronary atherosclerosis in the general population with high levels of OM3. Future trials are warranted comparing the effect of high-dose DHA and EPA on atherosclerosis and cardiovascular outcomes., Author(s): Akira Sekikawa [sup.1], Hemant Mahajan [sup.1], Sayaka Kadowaki [sup.2], Takashi Hisamatsu [sup.3], Naoko Miyagawa [sup.2], Akira Fujiyoshi [sup.2], Aya Kadota [sup.4], Hiroshi Maegawa [sup.5], Kiyoshi Murata [sup.6], Katsuyuki Miura [...]

Published
2019
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10. Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Fujiyoshi, Akira, Miura, Katsuyuki, Kadowaki, Sayaka, Azuma, Koichiro, Tanaka, Sachiko, Hisamatsu, Takashi, Arima, Hisatomi, Kadota, Aya, Miyagawa, Naoko, Takashima, Naoyuki, Ohkubo, Takayoshi, Saitoh, Yoshino, Torii, Sayuki, Miyazawa, Itsuko, Maegawa, Hiroshi, Murata, Kiyoshi, and Ueshima, Hirotsugu

Published
2016
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11. Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

Author

Ueshima, Hirotsugu, Miura, Katsuyuki, Horie, Minoru, Nakano, Yasutaka, Yamamoto, Takashi, Ogawa, Emiko, Maegawa, Hiroshi, Miyazawa, Itsuko, Murata, Kiyoshi, Mitsunami, Kenichi, Nozaki, Kazuhiko, Shiino, Akihiko, Araki, Isao, Tsuru, Teruhiko, Toyama, Ikuo, Ogita, Hisakazu, Kurita, Souichi, Maeda, Toshinaga, Miyamatsu, Naomi, Kita, Toru, Kimura, Takeshi, Nishio, Yoshihiko, Nakamura, Yasuyuki, Okamura, Tomonori, Sekikawa, Akira, Barinas-Mitchell, Emma J.M., Edmundowicz, Daniel, Ohkubo, Takayoshi, Hozawa, Atsushi, Okuda, Nagako, Higashiyama, Aya, Nagasawa, Shinya, Kita, Yoshikuni, Murakami, Yoshitaka, Kadota, Aya, Fujiyoshi, Akira, Takashima, Naoyuki, Kadowaki, Takashi, Kadowaki, Sayaka, Abbott, Robert D., Ohno, Seiko, Arima, Hisatomi, Hisamatsu, Takashi, Miyagawa, Naoko, Torii, Sayuki, Saito, Yoshino, Zaid, Maryam, Suzuki, Sentaro, and Ito, Takahiro

Published
2016
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12. Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population

Author

Ueshima, Hirotsugu, Kadowaki, Takashi, Hisamatsu, Takashi, Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Sekikawa, Akira, Kadota, Aya, Kadowaki, Sayaka, Nakamura, Yasuyuki, Miyagawa, Naoko, Okamura, Tomonori, Kita, Yoshikuni, Takashima, Naoyuki, Kashiwagi, Atsunori, Maegawa, Hiroshi, Horie, Minoru, Yamamoto, Takashi, Kimura, Takeshi, and Kita, Toru

Published
2016
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14. Abstract P663: Significantly Slower Progression of Aortic Calcification Among Japanese in Japan Than White and Japanese Americans in a Multiethnic Cohort of Middle-Aged Men - ERA JUMP (Electron-Beam Computed Tomography and Risk Factor Assessment in Japanese and US Men in the Post-World War II Birth Cohort) Study

Author

Li, Mengyi, primary, Fujiyoshi, Akira, additional, Willcox, Bradley, additional, Li, Jiatong, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Kadowaki, Takashi, additional, Chang, Yuefang, additional, Miura, Katsuyuki, additional, Edmundowicz, Daniel, additional, Okamura, Tomonori, additional, Masaki, Kamal, additional, Ueshima, Hirotsugu, additional, and Sekikawa, Akira M, additional

Published
2023
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15. PS-C23-2: GUT MICROBIOTA AND SUBCLINICAL CORONARY ARTERY CALCIFICATION IN A GENERAL POPULATION OF JAPANESE MEN

Author

Okami, Yukiko, primary, Arima, Hisatomi, additional, Kondo, Keiko, additional, Hexun, Zhang, additional, Yano, Yuichiro, additional, Kadota, Aya, additional, Torii, Sayuki, additional, Hisamatsu, Takashi, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Watanabe, Yoshiyuki, additional, Ando, Akira, additional, Nakagawa, Yoshihisa, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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17. Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification

Author

Ganbaatar, Namuun, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Araki, Shin-Ichi, additional, Kume, Shinji, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Segawa, Hiroyoshi, additional, Salman, Ebtehal, additional, Miyazawa, Itsuko, additional, Yamamoto, Takashi, additional, Nakagawa, Yoshihisa, additional, Maegawa, Hiroshi, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2022
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18. Ethnic difference in liver fat content: A cross-sectional observation among Japanese American in Hawaii, Japanese in Japan, and non-Hispanic whites in United States

Author

Azuma, Koichiro, Curb, J. David, Kadowaki, Takashi, Edmundowicz, Daniel, Kadowaki, Sayaka, Masaki, Kamal H., El-Saed, Aiman, Nishio, Yoshihiko, Seto, Todd B., Okamura, Tomonori, Cetinel, Cemal, Kadota, Aya, Sutton-Tyrrell, Kim, Miura, Katsuyuki, Evans, Rhobert W., Takamiya, Tomoko, Maegawa, Hiroshi, Miljkovic, Iva, Kuller, Lewis H., Ueshima, Hirotsugu, Kelley, David E., and Sekikawa, Akira

Published
2013
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20. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Sumi, Masaki, Hisamatsu, Takashi, Fujiyoshi , Akira, Kadota, Aya, Miyagawa, Naoko, Kondo, Keiko, Kadowaki, Sayaka, Suzuki , Sentaro, Torii, Sayuki, Zaid Maryam, Sato, Atsushi, Arima, Hisatomi, Terada, Tomohiro, Miura, Katsuyuki, Ueshima , Hirotsugu, Horie Minoru, Nakano Yasutaka, Yamamoto Takashi, Hayashi Hideki, Ogawa Emiko, Maegawa Hiroshi, Miyazawa Itsuko, Murata Kiyoshi, Mitsunami Kenichi, Nozaki Kazuhiko, Tooyama Ikuo, Shiino Akihiko, Tsuru Teruhiko, Ogita Hisakazu, Shimizu Akio, Miyamatsu Naomi, Kita Toru, Kimura Takeshi, Nishio Yoshihiko, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Edmundowicz Daniel, Ohkubo Takayoshi, Hozawa Atsushi, Murakami Yoshitaka, Okuda Nagako, Arima Hisatomi, Kita Yoshikuni, Hisamatsu Takashi, Higashiyama Aya, Nagasawa Shinya, Azuma Koichiro, Yanagita Masahiko, Abbott Robert D., Kadota Aya, Ohno Seiko, Fujiyoshi Akira, Takashima Naoyuki, Kadowaki Takashi, Kadowaki Sayaka, Miyagawa Naoko, Kondo Keiko, Torii Sayuki, Saito Yoshino, Suzuki Sentaro, Ito Takahiro, Satoh Atsushi, and Yamazoe Masahiro

Subjects
Adult, Male, medicine.medical_specialty, Alcohol Drinking, Epidemiology, alcohol consumption, Population, Adipose tissue, 030209 endocrinology & metabolism, Intra-Abdominal Fat, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, visceral adipose tissue, Adverse effect, education, Nutrition, Aged, lcsh:R5-920, education.field_of_study, Anthropometry, business.industry, anthropometric obesity indice, Confounding, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, fat deposition, Obesity, Subcutaneous Fat, Abdominal, Epidemiologic Studies, Cross-Sectional Studies, Population Surveillance, Original Article, lcsh:Medicine (General), Tomography, X-Ray Computed, business, Body mass index
Abstract

Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend

Published
2019
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21. A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium

Author

Zaid, Maryam, primary, Fujiyoshi, Akira, additional, Hisamatsu, Takashi, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Satoh, Atsushi, additional, Sekikawa, Akira, additional, Barinas-Mitchell, Emma, additional, Horie, Minoru, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2022
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23. Cross-Sectional Comparison of Coronary Artery Calcium Scores Between Caucasian Men in the United States and Japanese Men in Japan: The Multi-Ethnic Study of Atherosclerosis and the Shiga Epidemiological Study of Subclinical Atherosclerosis

Author

Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Kadowaki, Takashi, Kadowaki, Sayaka, Zaid, Maryam, Hisamatsu, Takashi, Sekikawa, Akira, Budoff, Matthew J., Liu, Kiang, Ueshima, Hirotsugu, Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Kadowaki, Takashi, Kadowaki, Sayaka, Zaid, Maryam, Hisamatsu, Takashi, Ueshima, Hirotsugu, Miura, Katsuyuki, Hisamatsu, Takashi, Ueshima, Hirotsugu, Ohkubo, Takayoshi, Sekikawa, Akira, Budoff, Matthew J., and Liu, Kiang

Published
2014
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24. Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men

Author

Kimani Cecilia, Kadota Aya, Miura Katsuyuki, Fujiyoshi Akira, Zaid Maryam, Kadowaki Sayaka, Hisamatsu Takashi, Arima Hisatomi, Horie Minoru, Ueshima Hirotsugu, Yamamoto Takashi, Maegawa Hiroshi, Murata Kiyoshi, Nozaki Kazuhiko, Shiino Akihiko, Toyama Ikuo, Tsuru Teruhiko, Ogita Hisakazu, Takashima Naoyuki, Kadowaki Takashi, Miyamatsu Naomi, Miyagawa Naoko, Torii Sayuki, Hayashi Hideki, Nakano Yasutaka, Ogawa Emiko, Miyazawa Itsuko, Shimizu Akio, Abbott Robert D., Kondo Keiko, Suzuki Sentaro, Ito Takahiro, Andoh Akira, Kunimura Ayako, Nishio Yoshihiko, Mitsunami Kenichi, Kita Toru, Kimura Takeshi, Tabara Yasuharu, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Ohkubo Takayoshi, Kita Yoshikuni, Murakami Yoshitaka, Hozawa Atsushi, Okuda Nagako, Higashiyama Aya, Ohno Seiko, Nagasawa Shinya, Yamazo Masahiro, Saito Yoshino, Edmundowicz Daniel, Satoh Atsushi, Azuma Koichiro, Yanagita Masahiko, Sawamura Tatsuya, and Igase Michiya

Subjects
Adult, Male, medicine.medical_specialty, Aortic Diseases, Renal function, Blood lipids, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary artery, Logistic regression, Calcification, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Internal Medicine, Humans, Medicine, cardiovascular diseases, Vascular Calcification, Generalized estimating equation, Aorta, Aged, 2. Zero hunger, business.industry, Incidence, Biochemistry (medical), nutritional and metabolic diseases, Odds ratio, Middle Aged, Prognosis, medicine.disease, Coronary Vessels, Aortic artery, Cardiovascular diseases, Risk factors, 3. Good health, Blood pressure, Cardiology, Original Article, Cardiology and Cardiovascular Medicine, business, Body mass index, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Aims: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. Methods: We examined a random sample of 1035 Japanese men aged 40–79 years. CAC and AAC were measured by computed tomography and scored according to the Agatston method. Using a logistic regression, we calculated the odds ratio (OR) as being in the highest quintile (Q5) of the calcification score compared to the lower quintiles (Q1–Q4) per 1 standard deviation higher CVD risk factor. Models were simultaneously adjusted for age, body mass index (BMI), systolic blood pressure, smoking (pack-year), alcohol intake, hemoglobin A1c, uric acid, estimated glomerular filtration rate (eGFR), serum lipids, and C-reactive protein. Differences in ORs were investigated using a generalized estimating equation. We performed a multiple linear regression using log-transformed CAC and AAC values as dependent variables. Results: CAC and AAC were independently associated with age (OR, 95% CI: 2.30 [1.77–2.98] for CAC and 3.48 [2.57–4.73] for AAC), p for difference < 0.001), systolic blood pressure (1.29 [1.08–1.53] and 1.28 [1.07–1.54], p for difference = 0.270), and smoking (1.22, [1.04–1.43] and 1.34 [1.13–1.58]) p for difference = 0.071). Alcohol correlated with AAC only (1.17 [0.97–1.41] for CAC and 1.42 [1.16–1.73] for AAC, p for difference = 0.020). Conclusions: CAC and AAC were associated with similar CVD risk factors. The strength of association slightly differed between CAC and AAC.

Published
2019

25. Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men

Author

Motoyama, Kenneth R, Curb, J David, Kadowaki, Takashi, El-Saed, Aiman, Abbott, Robert D, Okamura, Tomonori, Evans, Rhobert W, Nakamura, Yasuyuki, Sutton-Tyrrell, Kim, Rodriquez, Beatriz L, Kadota, Aya, Edmundowicz, Daniel, Willcox, Bradley J, Choo, Jina, Katsumi, Nakata, Otake, Teruo, Kadowaki, Sayaka, Kuller, Lewis H, Ueshima, Hirotusgu, and Sekikawa, Akira

Published
2009
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28. Congenital Hypofibrinogenemia in a Neonate with a Novel Mutation in theFGBGene

Author

Shinozuka, Jun, Okumura, Nobuo, Nagasawa, Mayumi, Nishikado, Motokazu, Kadowaki, Sayaka, Katsuda, Itsuro, Imashuku, Shinasku, Shinozuka, Jun, Okumura, Nobuo, Nagasawa, Mayumi, Nishikado, Motokazu, Kadowaki, Sayaka, Katsuda, Itsuro, and Imashuku, Shinasku

Abstract

Article, Pediatric reports. 13(1): 113-117(2021)

Published
2021

29. Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: population based prospective cohort study

Author

Sekikawa, Akira, Miura, Katsuyuki, Lee, Sunghee, Fujiyoshi, Akira, Edmundowicz, Daniel, Kadowaki, Takashi, Evans, Rhobert W, Kadowaki, Sayaka, Sutton-Tyrrell, Kim, Okamura, Tomonori, Bertolet, Marnie, Masaki, Kamal H, Nakamura, Yasuyuki, Barinas-Mitchell, Emma J M, Willcox, Bradley J, Kadota, Aya, Seto, Todd B, Maegawa, Hiroshi, Kuller, Lewis H, and Ueshima, Hirotsugu

Published
2014
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30. Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men

Author

KADOWAKI, Sayaka, KADOWAKI, Takashi, HOZAWA, Atsushi, FUJIYOSHI, Akira, HISAMATSU, Takashi, SATOH, Atsushi, ARIMA, Hisatomi, Tanaka-Mizuno, Sachiko, TORII, Sayuki, KONDO, Keiko, KADOTA, Aya, Masaki, Kamal, OKAMURA, Tomonori, OHKUBO, Takayoshi, MIURA, Katsuyuki, UESHIMA, Hirotsugu, and Shiga, Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

Subjects
Male, medicine.medical_specialty, Population level, Physiology, Office blood pressure, Population, Blood Pressure, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Linear regression, Internal Medicine, Medicine, Humans, 030212 general & internal medicine, education, Rest time, Antihypertensive Agents, education.field_of_study, business.industry, Home blood pressure, Blood Pressure Determination, General population, Blood Pressure Monitoring, Ambulatory, Individual level, Blood pressure, Hypertension, Cardiology and Cardiovascular Medicine, business
Abstract

Conventional office blood pressure (OBP) and home blood pressure (HBP) measurements are often inconsistent. The purpose of this research was (1) to test whether strictly measured OBP values with sufficient rest time before measurement (st-OBP) is comparable to HBP at the population level and (2) to ascertain whether there are particular determinants for the difference between HBP and st-OBP at the individual level. Data from a population-based group of 1056 men aged 40–79 years were analyzed. After a five-min rest, st-OBP was measured twice. HBP was measured after a 2-min rest every morning for seven consecutive days. To determine factors related to ΔSBP (HBP minus st-OBP measurements), multiple linear regression analyses and analyses of covariance were performed. While st-OBP and HBP were comparable (136.5 vs. 137.2 mmHg) at the population level, ΔSBP varied with a standard deviation of 13.5 mmHg. Smoking was associated with a larger ΔSBP regardless of antihypertensive usage, and BMI was associated with a larger ΔSBP in participants using antihypertensive drugs. The adjusted mean ΔSBP in the highest BMI tertile category was 4.6 mmHg in participants taking antihypertensive drugs. st-OBP and HBP measurements were comparable at the population level, although the distribution of ΔSBP was considerably broad. Smokers and obese men taking antihypertensive drugs had higher HBP than st-OBP, indicating that their blood pressure levels are at risk of being underestimated. Therefore, this group would benefit from the addition of HBP measurements.

Published
2020

31. Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study

Author

Fujiyoshi Akira, Miura Katsuyuki, Ohkubo Takayoshi, Miyagawa Naoko, Saito Yoshino, Miyazawa Itsuko, Shiino Akihiko, Kadota Aya, Kadowaki Sayaka, Hisamatsu , Takashi, Torii , Sayuki, Takashima, Naoyuki, Tooyama, Ikuo, Ueshima, Hirotsugu, Fujiyoshi Akira, Miura Katsuyuki, Ohkubo Takayoshi, Miyagawa Naoko, Saito Yoshino, Miyazawa Itsuko, Shiino Akihiko, Kadota Aya, Kadowaki Sayaka, Hisamatsu , Takashi, Torii , Sayuki, Takashima, Naoyuki, Tooyama, Ikuo, and Ueshima, Hirotsugu

Published
2020

33. Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Author

Syaifullah, Ali Haidar, primary, Shiino, Akihiko, additional, Fujiyoshi, Akira, additional, Kadota, Aya, additional, Kondo, Keiko, additional, Ito, Takahiro, additional, Segawa, Hiroyoshi, additional, Moniruzzaman, Mohammad, additional, Waki, Takashi, additional, Miyagawa, Naoko, additional, Tooyama, Ikuo, additional, Ueshima, Hirotsugu, additional, Miura, Katsuyuki, additional, Horie, Minoru, additional, Nakagawa, Yoshihisa, additional, Yamamoto, Takashi, additional, Nakano, Yasutaka, additional, Ogawa, Emiko, additional, Maegawa, Hiroshi, additional, Morino, Katsutaro, additional, Miyazawa, Itsuko, additional, Watanabe, Yoshiyuki, additional, Nozaki, Kazuhiko, additional, Andoh, Akira, additional, Tsuru, Teruhiko, additional, Ogita, Hisakazu, additional, Miyamatsu, Naomi, additional, Nakamura, Yasuyuki, additional, Torii, Sayuki, additional, Kadowaki, Takashi, additional, Kadowaki, Sayaka, additional, Suzuki, Sentaro, additional, Kunimura, Ayako, additional, Higashiyama, Aya, additional, Okamura, Tomonori, additional, Azuma, Koichiro, additional, Sawamura, Tatsuya, additional, Igase, Michiya, additional, Tabara, Yasuharu, additional, Sekikawa, Akira, additional, Barinas-Mitchell, Emma J.M., additional, Edmundowicz, Daniel, additional, Ohkubo, Takayoshi, additional, Hozawa, Atsushi, additional, Murakami, Yoshitaka, additional, Okuda, Nagako, additional, Arima, Hisatomi, additional, Satoh, Atsushi, additional, Kita, Yoshikuni, additional, Hisamatsu, Takashi, additional, Yanagita, Masahiko, additional, Abbott, Robert D., additional, Ohno, Seiko, additional, Takashima, Naoyuki, additional, Zaid, Maryam, additional, and Saito, Yoshino, additional

Published
2021
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34. A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and US Whites

Author

Fujiyoshi, Akira, Sekikawa, Akira, Shin, Chol, Masaki, Kamal, David Curb, J., Ohkubo, Takayoshi, Miura, Katsuyuki, Kadowaki, Takashi, Kadowaki, Sayaka, Kadota, Aya, Edmundowicz, Daniel, Shah, Amber, Evans, Rhobert W., Bertolet, Marianne, Choo, Jina, Willcox, Bradley J., Okamura, Tomonori, Maegawa, Hiroshi, Murata, Kiyoshi, Kuller, Lewis H., and Ueshima, Hirotsugu

Published
2013
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35. Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study

Author

Fujiyoshi, Akira, primary, Miura, Katsuyuki, additional, Ohkubo, Takayoshi, additional, Miyagawa, Naoko, additional, Saito, Yoshino, additional, Miyazawa, Itsuko, additional, Shiino, Akihiko, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Hisamatsu, Takashi, additional, Torii, Sayuki, additional, Takashima, Naoyuki, additional, Tooyama, Ikuo, additional, and Ueshima, Hirotsugu, additional

Published
2020
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36. Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Tai Pham, Fujiyoshi Akira, Arima Hisatomi, Tanaka-Mizuno Sachiko, Hisamatsu Takahashi, Kadowaki Sayaka, Kadota Aya, Zaid Maryam, Sekikawa Akira, Yamamoto Takashi, Horie Minoru, Miura Katsuyuki, Ueshima Hirotsugu, Tai Pham, Fujiyoshi Akira, Arima Hisatomi, Tanaka-Mizuno Sachiko, Hisamatsu Takahashi, Kadowaki Sayaka, Kadota Aya, Zaid Maryam, Sekikawa Akira, Yamamoto Takashi, Horie Minoru, Miura Katsuyuki, and Ueshima Hirotsugu

Published
2018

38. Corrigendum to “Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population.” [Atherosclerosis 246 (March 2016) 141–147]

Author

Ueshima, Hirotsugu, primary, Kadowaki, Takashi, additional, Hisamatsu, Takashi, additional, Fujiyoshi, Akira, additional, Miura, Katsuyuki, additional, Ohkubo, Takayoshi, additional, Sekikawa, Akira, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Nakamura, Yasuyuki, additional, Miyagawa, Naoko, additional, Okamura, Tomonori, additional, Kita, Yoshikuni, additional, Takashima, Naoyuki, additional, Kashiwagi, Atsunori, additional, Maegawa, Hiroshi, additional, Horie, Minoru, additional, Yamamoto, Takashi, additional, Kimura, Takeshi, additional, and Kita, Toru, additional

Published
2018
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40. Abstract P014: Lower eGFR and Proteinuria Were Independently Associated With Lower Cognitive Abilities in Community-dwelling Men in Japan: SESSA study

Author

Fujiyoshi, Akira, primary, Ohkubo, Takayoshi, additional, Miura, Katsuyuki, additional, Shiino, Akihiko, additional, Miyagawa, Naoko, additional, Takashima, Naoyuki, additional, Saitoh, Yoshino, additional, Torii, Sayuki, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Hisamatsu, Takashi, additional, Miyazawa, Itsuko, additional, Tooyama, Ikuo, additional, and Ueshima, Hirotsugu, additional

Published
2017
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41. Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

Author

Zaid, Maryam, primary, Miura, Katsuyuki, additional, Fujiyoshi, Akira, additional, Abbott, Robert D., additional, Hisamatsu, Takashi, additional, Kadota, Aya, additional, Arima, Hisatomi, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Miyagawa, Naoko, additional, Suzuki, Sentaro, additional, Takashima, Naoyuki, additional, Ohkubo, Takayoshi, additional, Sekikawa, Akira, additional, Maegawa, Hiroshi, additional, Horie, Minoru, additional, Nakamura, Yasuyuki, additional, Okamura, Tomonori, additional, Ueshima, Hirotsugu, additional, Nakano, Yasutaka, additional, Yamamoto, Takashi, additional, Ogawa, Emiko, additional, Miyazawa, Itsuko, additional, Murata, Kiyoshi, additional, Mitsunami, Kenichi, additional, Nozaki, Kazuhiko, additional, Shiino, Akihiko, additional, Araki, Isao, additional, Tsuru, Teruhiko, additional, Toyama, Ikuo, additional, Ogita, Hisakazu, additional, Kurita, Souichi, additional, Maeda, Toshinaga, additional, Miyamatsu, Naomi, additional, Kita, Toru, additional, Kimura, Takeshi, additional, Nishio, Yoshihiko, additional, Barinas-Mitchell, Emma J.M., additional, Edmundowicz, Daniel, additional, Hozawa, Atsushi, additional, Okuda, Nagako, additional, Higashiyama, Aya, additional, Nagasawa, Shinya, additional, Kita, Yoshikuni, additional, Murakami, Yoshitaka, additional, Kadowaki, Takashi, additional, Ohno, Seiko, additional, Saito, Yoshino, additional, Zaid, Maryam, additional, and Ito, Takahiro, additional

Published
2016
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42. Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men

Author

Hisamatsu, Takashi, primary, Miura, Katsuyuki, additional, Arima, Hisatomi, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Suzuki, Sentaro, additional, Miyagawa, Naoko, additional, Sato, Atsushi, additional, Yamazoe, Masahiro, additional, Fujiyoshi, Akira, additional, Ohkubo, Takayoshi, additional, Yamamoto, Takashi, additional, Murata, Kiyoshi, additional, Abbott, Robert D., additional, Sekikawa, Akira, additional, Horie, Minoru, additional, Ueshima, Hirotsugu, additional, Nakano, Yasutaka, additional, Ogawa, Emiko, additional, Maegawa, Hiroshi, additional, Miyazawa, Itsuko, additional, Mitsunami, Kenichi, additional, Nozaki, Kazuhiko, additional, Shiino, Akihiko, additional, Araki, Isao, additional, Tsuru, Teruhiko, additional, Toyama, Ikuo, additional, Ogita, Hisakazu, additional, Kurita, Souichi, additional, Maeda, Toshinaga, additional, Miyamatsu, Naomi, additional, Kita, Toru, additional, Kimura, Takeshi, additional, Nishio, Yoshihiko, additional, Nakamura, Yasuyuki, additional, Okamura, Tomonori, additional, Barinas‐Mitchell, Emma J.M., additional, Edmundowicz, Daniel, additional, Hozawa, Atsushi, additional, Okuda, Nagako, additional, Higashiyama, Aya, additional, Nagasawa, Shinya, additional, Kita, Yoshikuni, additional, Murakami, Yoshitaka, additional, Takashima, Naoyuki, additional, Kadowaki, Takashi, additional, Ohno, Seiko, additional, Kondo, Keiko, additional, Saito, Yoshino, additional, Zaid, Maryam, additional, Ito, Takahiro, additional, Shibukawa, Takeshi, additional, and Sumi, Masaki, additional

Published
2016
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43. Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components

Author

Yamazoe, Masahiro, primary, Hisamatsu, Takashi, additional, Miura, Katsuyuki, additional, Kadowaki, Sayaka, additional, Zaid, Maryam, additional, Kadota, Aya, additional, Torii, Sayuki, additional, Miyazawa, Itsuko, additional, Fujiyoshi, Akira, additional, Arima, Hisatomi, additional, Sekikawa, Akira, additional, Maegawa, Hiroshi, additional, Horie, Minoru, additional, and Ueshima, Hirotsugu, additional

Published
2016
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44. Abstract P222: Significant Inverse Association of Blood Levels of Marine Omega-3 Fatty Acids with Coronary Artery Calcification in Men in Japan

Author

Sekikawa, Akira, primary, Bertolet, Marnie, additional, Vishnu, Abhishek, additional, Ahuja, Vasudha, additional, Evans, Rhobert W, additional, Kuller, Lewis H, additional, Fujiyoshi, Akira, additional, Hisamatsu, Takashi, additional, Kadowaki, Takashi, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Arima, Hisatomi, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2016
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45. Abstract P184: Is Home Blood Pressure More Strongly Associated with Coronary Artery Calcification Than Clinic Blood Pressure Measured Under an Appropriate Condition?

Author

Satoh, Atsushi, primary, Arima, Hisatomi, additional, Hozawa, Atsushi, additional, Hisamatsu, Takashi, additional, Kadowaki, Sayaka, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Miyagawa, Naoko, additional, Zaid, Maryam, additional, Torii, Sayuki, additional, Ohkubo, Takayoshi, additional, Okamura, Tomonori, additional, Sekikawa, Akira, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2016
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46. Abstract MP73: Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome in a General Population

Author

Yamazoe, Masahiro, primary, Hisamatsu, Takashi, additional, Miura, Katsuyuki, additional, Kadowaki, Sayaka, additional, Zaid, Maryam, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Abbott, Robert, additional, Arima, Hisatomi, additional, Sekikawa, Akira, additional, Maegawa, Hiroshi, additional, Horie, Minoru, additional, and Ueshima, Hirotsugu, additional

Published
2016
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47. International Comparison of Abdominal Fat Distribution Among Four Populations: The ERA-JUMP Study.

Author

Kadowaki, Sayaka, Miura, Katsuyuki, Kadowaki, Takashi, Fujiyoshi, Akira, El-Saed, Aiman, Masaki, Kamal H., Okamura, Tomonori, Edmundowicz, Daniel, Rodriguez, Beatriz L., Nakamura, Yasuyuki, Barinas-Mitchell, Emma J.M., Kadota, Aya, Willcox, Bradley J., Abbott, Robert D., Kuller, Lewis H., Choo, Jina, Shin, Chol, Ueshima, Hirotsugu, Sekikawa, Akira, and for the ERA JUMP Study Group

Abstract

Background: Abdominal fat distribution varies across groups with different races or environments. Whether environmental factors, apart from racial differences, affect abdominal fat distribution is unknown. Methods: We compared the abdominal fat distribution of four groups; different races with similar environments (Caucasians vs. Japanese Americans), different environments with an identical race (Japanese Americans vs. Japanese), and similar races with similar environments (Japanese vs. Koreans). A population-based sample of 1212 men aged 40–49 were analyzed: 307 Caucasians and 300 Japanese Americans in the United States, 310 Japanese in Japan, and 295 Koreans in Korea. We compared the proportion of visceral adipose tissue area to total abdominal adipose tissue area (VAT%) and other factors that can affect abdominal fat distribution (smoking, alcohol use, physical activity levels, and metabolic factors). Results: VAT% was significantly higher in Japanese and Koreans than in Japanese Americans and Caucasians (50.0, 48.5, 43.2, 41.0%, respectively, P < 0.001). Even after adjustment for possible confounders, the significant VAT% difference remained in comparing groups with identical race but different environments (i.e., Japanese vs. Japanese Americans). In contrast, comparing groups with different races but similar environments (i.e., Caucasians vs. Japanese Americans), VAT% was not significantly different. Comparing groups with similar races and similar environments (i.e., Japanese vs. Koreans), VAT% did not significantly differ. Conclusions: Environmental differences, apart from racial differences, affect the difference in abdominal fat distribution across different groups in middle-aged men. [ABSTRACT FROM AUTHOR]

Published
2018
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48. Association of serum n−6 and n−3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men123

Author

Motoyama, Kenneth R, Curb, J David, Kadowaki, Takashi, El-Saed, Aiman, Abbott, Robert D, Okamura, Tomonori, Evans, Rhobert W, Nakamura, Yasuyuki, Sutton-Tyrrell, Kim, Rodriquez, Beatriz L, Kadota, Aya, Edmundowicz, Daniel, Willcox, Bradley J, Choo, Jina, Katsumi, Nakata, Otake, Teruo, Kadowaki, Sayaka, Kuller, Lewis H, Ueshima, Hirotusgu, and Sekikawa, Akira

Subjects
Adult, Alcohol Drinking, Cholesterol, HDL, Smoking, food and beverages, Fasting, Middle Aged, Pennsylvania, Lipids, eye diseases, United States, White People, Cross-Sectional Studies, Asian People, Japan, Fatty Acids, Omega-6, Surveys and Questionnaires, Fatty Acids, Omega-3, Humans, lipids (amino acids, peptides, and proteins), sense organs, human activities, Life Style, Triglycerides
Abstract

The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known.Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40-49 y.We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used.Serum n-6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [beta = -0.39 (P0.001), -0.38 (P0.001), and -0.33 (P0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [beta = -0.15 (P0.001), -0.22 (P0.001), and -0.13 (P0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (beta = 4.49, P0.001) and Japanese (beta = 3.73, P0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (beta = 2.15, P0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (beta = 2.68, P0.01).Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations.

Published
2009

49. Abstract P134: Lifetime Cigarette Smoking is Associated with Increased Indices of Abdominal Obesity Independent of Body Mass Index: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Fujiyoshi, Akira, primary, Miura, Katsuyuki, additional, Kadowaki, Sayaka, additional, Kadota, Aya, additional, Ohkubo, Takayoshi, additional, Miyagawa, Naoko, additional, Hisamatsu, Takashi, additional, Yoshino, Saitoh, additional, Torii, Sayuki, additional, Miyazawa, Itsuko, additional, Mitsunami, Kenichi, additional, Maegawa, Hiroshi, additional, Murata, Kiyoshi, additional, and Ueshima, Hirotsugu, additional

Published
2014
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50. Abstract P426: Association of Serum Soy Isoflavones with Metabolic Markers in Japanese Men and Women

Author

Evans, Rhobert W, primary, Sekikawa, Akira, additional, Kadowaki, Takashi, additional, Vishnu, Abhishek, additional, Kadowaki, Sayaka, additional, El-Saed, Aiman, additional, Fujiyoshi, Akira, additional, Ahuja, Vasudha, additional, Okamura, Tomonori, additional, Miura, Katsuyuki, additional, Kuller, Lewis H, additional, and Ueshima, Hirotsugu, additional

Published
2014
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