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6. Modulation of limbic resting-state networks by subthalamic nucleus deep brain stimulation

Author

Eraifej, John, primary, Cabral, Joana, additional, Fernandes, Henrique M., additional, Kahan, Joshua, additional, He, Shenghong, additional, Mancini, Laura, additional, Thornton, John, additional, White, Mark, additional, Yousry, Tarek, additional, Zrinzo, Ludvic, additional, Akram, Harith, additional, Limousin, Patricia, additional, Foltynie, Tom, additional, Aziz, Tipu Z., additional, Deco, Gustavo, additional, Kringelbach, Morten, additional, and Green, Alexander L., additional

Published
2023
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20. Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza

Author

Merkler, Alexander E., primary, Parikh, Neal S., additional, Mir, Saad, additional, Gupta, Ajay, additional, Kamel, Hooman, additional, Lin, Eaton, additional, Lantos, Joshua, additional, Schenck, Edward J., additional, Goyal, Parag, additional, Bruce, Samuel S., additional, Kahan, Joshua, additional, Lansdale, Kelsey N., additional, LeMoss, Natalie M., additional, Murthy, Santosh B., additional, Stieg, Philip E., additional, Fink, Matthew E., additional, Iadecola, Costantino, additional, Segal, Alan Z., additional, Cusick, Marika, additional, Campion, Thomas R., additional, Diaz, Ivan, additional, Zhang, Cenai, additional, and Navi, Babak B., additional

Published
2020
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24. Bilateral nucleus basalis of Meynert deep brain stimulation for dementia with Lewy bodies: A randomised clinical trial

Author

Gratwicke, James, primary, Zrinzo, Ludvic, additional, Kahan, Joshua, additional, Peters, Amy, additional, Brechany, Una, additional, McNichol, Ann, additional, Beigi, Mazda, additional, Akram, Harith, additional, Hyam, Jonathan, additional, Oswal, Ashwini, additional, Day, Brian, additional, Mancini, Laura, additional, Thornton, John, additional, Yousry, Tarek, additional, Crutch, Sebastian J., additional, Taylor, John-Paul, additional, McKeith, Ian, additional, Rochester, Lynn, additional, Schott, Jonathan M., additional, Limousin, Patricia, additional, Burn, David, additional, Rossor, Martin N., additional, Hariz, Marwan, additional, Jahanshahi, Marjan, additional, and Foltynie, Thomas, additional

Published
2020
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25. Risk of Ischemic Stroke in Patients with Covid-19 versus Patients with Influenza

Author

Merkler, Alexander E., primary, Parikh, Neal S., additional, Mir, Saad, additional, Gupta, Ajay, additional, Kamel, Hooman, additional, Lin, Eaton, additional, Lantos, Joshua, additional, Schenck, Edward J., additional, Goyal, Parag, additional, Bruce, Samuel S., additional, Kahan, Joshua, additional, Lansdale, Kelsey N., additional, LeMoss, Natalie M., additional, Murthy, Santosh B., additional, Stieg, Philip E., additional, Fink, Matthew E., additional, Iadecola, Costantino, additional, Segal, Alan Z., additional, Campion, Thomas R., additional, Diaz, Ivan, additional, Zhang, Cenai, additional, and Navi, Babak B., additional

Published
2020
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26. Predicting the need for retreatment in venous sinus stenting for idiopathic intracranial hypertension.

Author

Kahan, Joshua, Sundararajan, Sri, Brown, Kenroy, Dinkin, Marc, Oliveira, Cristiano, and Patsalides, Athos

Subjects
ACADEMIC medical centers, MANOMETERS, SURGICAL stents, RETROSPECTIVE studies, TREATMENT effectiveness, REOPERATION, LUMBAR puncture, ANGIOGRAPHY, LOGISTIC regression analysis, INTRACRANIAL hypertension, LONGITUDINAL method
Abstract

Background Idiopathic intracranial hypertension is a disease of raised intra-cranial pressure of unknown etiology. Lateral cerebral venous sinus stenosis (VSS) has been increasingly reported in these patients, and stenting has emerged as an alternative treatment for medically refractory symptoms. Treatment efficacy on meta-analysis appears promising, but identifying which patients are likely to benefit most, and which are likely to require repeat procedures, is currently unclear. Methods We retrospectively reviewed a prospectively collected database of 79 patients treated with venous sinus stenting at a single academic center with minimum follow-up of 18 months. We extracted baseline clinical data, as well as manometry at lumbar puncture and during angiography, and used logistic regression to identify parameters that could predict stent failure. Results Retreatment rate after successful VSS was 13.9%. Lumbar puncture opening pressure (OP) was shown to significantly predict treatment failure (ß=0.06; OR=1.064 (1.003--1.135); P=0.039). This effect remained significant when age, sex and body mass index were added to the model (ß=0.06; OR=1.066 (1.002--1.140); P=0.043). OP was correlated with venous sinus manometry readings in the superior sagittal and transverse sinus pre-stent placement, as well transstenotic gradient (P<0.001). Conclusions Higher lumbar puncture OP was associated with an increased risk of stent failure in transverse sinus stenting for idiopathic intracranial hypertension, although the performance of this model as a linear discriminator was poor. Further studies are required to better assess which patients are at greatest risk of treatment failure. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease

Author

Saenger, Victor M., primary, Kahan, Joshua, additional, Foltynie, Tom, additional, Friston, Karl, additional, Aziz, Tipu Z., additional, Green, Alexander L., additional, van Hartevelt, Tim J., additional, Cabral, Joana, additional, Stevner, Angus B. A., additional, Fernandes, Henrique M., additional, Mancini, Laura, additional, Thornton, John, additional, Yousry, Tarek, additional, Limousin, Patricia, additional, Zrinzo, Ludvic, additional, Hariz, Marwan, additional, Marques, Paulo, additional, Sousa, Nuno, additional, Kringelbach, Morten L., additional, and Deco, Gustavo, additional

Published
2017
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29. Uncovering the underlying mechanisms and whole-brain dynamics of therapeutic deep brain stimulation for Parkinson's disease

Author

Saenger, Victor M, primary, Kahan, Joshua, additional, Foltynie, Tom, additional, Friston, Karl, additional, Aziz, Tipu Z, additional, Green, Alexander L, additional, van Hartevelt, Tim J, additional, Stevner, Angus B. A., additional, Fernandes, Henrique M, additional, Mancini, Laura, additional, Thornton, John, additional, Yousry, Tarek, additional, Limousin, Patricia, additional, Zrinzo, Ludvic, additional, Hariz, Marwan, additional, Kringelbach, Morten L, additional, and Deco, Gustavo, additional

Published
2016
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30. Understanding DCM: Ten simple rules for the clinician (author copy)

Author

Kahan, Joshua

Abstract

This is an author copy of the paper published in Neuroimage (http://goo.gl/v5SOGF). Abstract Despite almost a decade since the introduction of Dynamic Causal Modelling (DCM), there remains some confusion within the wider neuroimaging, neuroscience and clinical communities as to what DCM studies are probing, and what all the jargon means. We provide ten simple rules, and a theoretical example to gently introduce the reader to the rationale behind DCM analyses, and how one should consider neuroimaging data and experiments that use DCM. It is deliberately written as a primer or orientation for non-technical imaging neuroscientists or clinicians who have had to contend with the technical intricacies of understanding DCM.

Published
2014
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34. Risk of Ischemic Stroke in Patients with Covid-19 versus Patients with Influenza.

Author

Merkler AE, Parikh NS, Mir S, Gupta A, Kamel H, Lin E, Lantos J, Schenck EJ, Goyal P, Bruce SS, Kahan J, Lansdale KN, LeMoss NM, Murthy SB, Stieg PE, Fink ME, Iadecola C, Segal AZ, Campion TR Jr, Diaz I, Zhang C, and Navi BB

Abstract

Importance: Case series without control groups suggest that Covid-19 may cause ischemic stroke, but whether Covid-19 is associated with a higher risk of ischemic stroke than would be expected from a viral respiratory infection is uncertain., Objective: To compare the rate of ischemic stroke between patients with Covid-19 and patients with influenza, a respiratory viral illness previously linked to stroke., Design: A retrospective cohort study., Setting: Two academic hospitals in New York City., Participants: We included adult patients with emergency department visits or hospitalizations with Covid-19 from March 4, 2020 through May 2, 2020. Our comparison cohort included adult patients with emergency department visits or hospitalizations with influenza A or B from January 1, 2016 through May 31, 2018 (calendar years spanning moderate and severe influenza seasons). Exposures: Covid-19 infection confirmed by evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the nasopharynx by polymerase chain reaction, and laboratory-confirmed influenza A or B. Main Outcomes and Measures: A panel of neurologists adjudicated the primary outcome of acute ischemic stroke and its clinical characteristics, etiological mechanisms, and outcomes. We used logistic regression to compare the proportion of Covid-19 patients with ischemic stroke versus the proportion among patients with influenza., Results: Among 2,132 patients with emergency department visits or hospitalizations with Covid-19, 31 patients (1.5%; 95% confidence interval [CI], 1.0%-2.1%) had an acute ischemic stroke. The median age of patients with stroke was 69 years (interquartile range, 66-78) and 58% were men. Stroke was the reason for hospital presentation in 8 (26%) cases. For our comparison cohort, we identified 1,516 patients with influenza, of whom 0.2% (95% CI, 0.0-0.6%) had an acute ischemic stroke. After adjustment for age, sex, and race, the likelihood of stroke was significantly higher with Covid-19 than with influenza infection (odds ratio, 7.5; 95% CI, 2.3-24.9)., Conclusions and Relevance: Approximately 1.5% of patients with emergency department visits or hospitalizations with Covid-19 experienced ischemic stroke, a rate 7.5-fold higher than in patients with influenza. Future studies should investigate the thrombotic mechanisms in Covid-19 in order to determine optimal strategies to prevent disabling complications like ischemic stroke.

Published
2020
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