1. Analgesic and anti-inflammatory activity of Cotinus coggygria Scop. extracts in vivo
- Author
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Kai Lu, Chong-Yu Yang, and Zhao-Hong Yan
- Subjects
antioxidant ,carrageenan ,cotinus coggygria scop. ,anti-inflammatory ,analgesic ,pain ,tnf-α ,fustin ,Arctic medicine. Tropical medicine ,RC955-962 ,Biology (General) ,QH301-705.5 - Abstract
Objective: To assess the analgesic and anti-inflammatory effects of standardized extract of Cotinus coggygria (C. coggygria) in different animal models. Methods: C. coggygria extracts (25, 50, and 100 mg/kg) were administered to rats and mice (n=6) during hot plate, tail-flick, acetic acid-induced writhing, and formalin tests to determine its analgesic efficacy. The anti-inflammatory activity of C. coggygria extracts was evaluated by histamine and carrageenan-induced paw edema, cotton pellet-induced granuloma, and acetic acid-induced peritoneal capillary dye leakage tests. Results: C. coggygria extracts (50 and 100 mg/kg) significantly alleviated thermal and chemical-induced pain in rodents (P
- Published
- 2024
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