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10. Modeling embryo-endometrial interface recapitulating human embryo implantation

Author

Shibata, Shun, primary, Endo, Shun, additional, Nagai, Luis A. E., additional, H. Kobayashi, Eri, additional, Oike, Akira, additional, Kobayashi, Norio, additional, Kitamura, Akane, additional, Hori, Takeshi, additional, Nashimoto, Yuji, additional, Nakato, Ryuichiro, additional, Hamada, Hirotaka, additional, Kaji, Hirokazu, additional, Kikutake, Chie, additional, Suyama, Mikita, additional, Saito, Masatoshi, additional, Yaegashi, Nobuo, additional, Okae, Hiroaki, additional, and Arima, Takahiro, additional

Published
2024
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12. Microfluidic vascular formation model for assessing angiogenic capacities of single islets.

Author

Nashimoto, Yuji, Konno, An, Imaizumi, Takuto, Nishikawa, Kaori, Ino, Kosuke, Hori, Takeshi, Kaji, Hirokazu, Shintaku, Hirofumi, Goto, Masafumi, and Shiku, Hitoshi

Abstract

Pancreatic islet transplantation presents a promising therapy for individuals suffering from type 1 diabetes. To maintain the function of transplanted islets in vivo, it is imperative to induce angiogenesis. However, the mechanisms underlying angiogenesis triggered by islets remain unclear. In this study, we introduced a microphysiological system to study the angiogenic capacity and dynamics of individual islets. The system, which features an open‐top structure, uniquely facilitates the inoculation of islets and the longitudinal observation of vascular formation in in vivo like microenvironment with islet‐endothelial cell communication. By leveraging our system, we discovered notable islet−islet heterogeneity in the angiogenic capacity. Transcriptomic analysis of the vascularized islets revealed that islets with high angiogenic capacity exhibited upregulation of genes related to insulin secretion and downregulation of genes related to angiogenesis and fibroblasts. In conclusion, our microfluidic approach is effective in characterizing the vascular formation of individual islets and holds great promise for elucidating the angiogenic mechanisms that enhance islet transplantation therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Contributors to the emerging investigators issue.

Author

Basu, Amar, Cheung, Karen C, Eddington, David T, Günther, Axel, Hansen, Carl, Huang, Tony Jun, Juncker, David, Kaji, Hirokazu, Khademhosseini, Ali, Khan, Saif A, Klapperich, Catherine, Love, J Christopher, Munson, Matthew, Murthy, Shashi, Ozcan, Aydogan, Ozinsky, Adrian, Spotts, James M, Squires, Todd, Takeuchi, Shoji, Wang, Wei, and Williams, Justin

Subjects
Analytical Chemistry, Chemical Sciences, Engineering
Published
2010

19. Contributors

Author

Adamo, Luigi, primary, Aron, Rebecca, additional, Bae, Hojae, additional, Borenstein, Jeffrey T., additional, Charest, Joseph L., additional, Chen, Li-Jiun, additional, Cooper, Madeline, additional, Coppeta, Jonathan, additional, Dash, Ajit, additional, Ekert, Jason E., additional, Esch, Mandy B., additional, García-Cardeña, Guillermo, additional, Getsios, Spiro, additional, Huh, Dongeun, additional, Jeong, Claire G., additional, Kaji, Hirokazu, additional, Khademhosseini, Ali, additional, Khalil, Ahmad S., additional, Leong, Kam W., additional, Mack, Peter, additional, Mahler, Gretchen J., additional, McCain, Megan L., additional, Mungenast, Alison E., additional, Dal Negro, Gianni, additional, Proctor, William R., additional, Raja, Waseem K., additional, Raut, Bibek, additional, Selimović, Šeila, additional, Seo, Jeongyun, additional, Slegtenhorst, Bendix R., additional, Tardiff, Daniel F., additional, Vedula, Else M., additional, Weinberg, Eli J., additional, White, James D., additional, Yang, Yong, additional, and Yip, Joycelyn K., additional

Published
2019
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24. Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes

Author

Farmacia y ciencias de los alimentos, Farmazia eta elikagaien zientziak, Ostrovidov, Serge, Ramalingam, Murugan, Bae, Hojae, Orive Arroyo, Gorka, Fujie, Toshinori, Hori, Takeshi, Nashimoto, Yuji, Shi, Xuetao, Kaji, Hirokazu, Farmacia y ciencias de los alimentos, Farmazia eta elikagaien zientziak, Ostrovidov, Serge, Ramalingam, Murugan, Bae, Hojae, Orive Arroyo, Gorka, Fujie, Toshinori, Hori, Takeshi, Nashimoto, Yuji, Shi, Xuetao, and Kaji, Hirokazu

Abstract

Molecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition seen naturally in the antibody/antigen complementarity. Because of their specificity, MIPs can be included in sensors as a recognition element coupled to a transducer part that converts the interaction of MIP/analyte into a quantifiable signal. Such sensors have important applications in the biomedical field in diagnosis and drug discovery, and are a necessary complement of tissue engineering for analyzing the functionalities of the engineered tissues. Therefore, in this review, we provide an overview of MIP sensors that have been used for the detection of skeletal- and cardiac-muscle-related analytes. We organized this review by targeted analytes in alphabetical order. Thus, after an introduction to the fabrication of MIPs, we highlight different types of MIP sensors with an emphasis on recent works and show their great diversity, their fabrication, their linear range for a given analyte, their limit of detection (LOD), specificity, and reproducibility. We conclude the review with future developments and perspectives.

Published
2023

25. Bioprinting and biomaterials for dental alveolar tissue regeneration

Author

Farmacia y ciencias de los alimentos, Farmazia eta elikagaien zientziak, Ostrovidov, Serge, Ramalingam, Murugan, Bae, Hojae, Orive Arroyo, Gorka, Fujie, Toshinori, Shi, Xuetao, Kaji, Hirokazu, Farmacia y ciencias de los alimentos, Farmazia eta elikagaien zientziak, Ostrovidov, Serge, Ramalingam, Murugan, Bae, Hojae, Orive Arroyo, Gorka, Fujie, Toshinori, Shi, Xuetao, and Kaji, Hirokazu

Abstract

Three dimensional (3D) bioprinting is a powerful tool, that was recently applied to tissue engineering. This technique allows the precise deposition of cells encapsulated in supportive bioinks to fabricate complex scaffolds, which are used to repair targeted tissues. Here, we review the recent developments in the application of 3D bioprinting to dental tissue engineering. These tissues, including teeth, periodontal ligament, alveolar bones, and dental pulp, present cell types and mechanical properties with great heterogeneity, which is challenging to reproduce in vitro. After highlighting the different bioprinting methods used in regenerative dentistry, we reviewed the great variety of bioink formulations and their effects on cells, which have been established to support the development of these tissues. We discussed the different advances achieved in the fabrication of each dental tissue to provide an overview of the current state of the methods. We conclude with the remaining challenges and future needs

Published
2023

26. Intrascleral Transplantation of a Collagen Sheet with Cultured Brain-Derived Neurotrophic Factor Expressing Cells Partially Rescues the Retina from Damage due to Acute High Intraocular Pressure

Author

Abe, Toshiaki, Tokita-Ishikawa, Yumi, Onami, Hideyuki, Katsukura, Yuki, Kaji, Hirokazu, Nishizawa, Matsuhiko, Nagai, Nobuhiro, Lambris, John D., Series editor, Ash, John D., editor, Grimm, Christian, editor, Hollyfield, Joe G., editor, Anderson, Robert E., editor, LaVail, Matthew M., editor, and Bowes Rickman, Catherine, editor

Published
2014
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28. 3D Bioprinting tissue analogs: Current development and translational implications

Author

Liu, Suihong, primary, Cheng, Lijia, additional, Liu, Yakui, additional, Zhang, Haiguang, additional, Song, Yongteng, additional, Park, Jeong-Hui, additional, Dashnyam, Khandmaa, additional, Lee, Jung-Hwan, additional, Khalak, Fouad Al-Hakim, additional, Riester, Oliver, additional, Shi, Zheng, additional, Ostrovidov, Serge, additional, Kaji, Hirokazu, additional, Deigner, Hans-Peter, additional, Pedraz, José Luis, additional, Knowles, Jonathan C, additional, Hu, Qingxi, additional, Kim, Hae-Won, additional, and Ramalingam, Murugan, additional

Published
2023
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36. Engineering systems for the generation of patterned co-cultures for controlling cell–cell interactions

Author

Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Biological Engineering, Kaji, Hirokazu, Camci-Unal, Gulden, Langer, Robert S, Khademhosseini, Ali, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Biological Engineering, Kaji, Hirokazu, Camci-Unal, Gulden, Langer, Robert S, and Khademhosseini, Ali

Abstract

Background: Inside the body, cells lie in direct contact or in close proximity to other cell types in a tightly controlled architecture that often regulates the resulting tissue function. Therefore, tissue engineering constructs that aim to reproduce the architecture and the geometry of tissues will benefit from methods of controlling cell-cell interactions with microscale resolution. Scope of the review: We discuss the use of microfabrication technologies for generating patterned co-cultures. In addition, we categorize patterned co-culture systems by cell type and discuss the implications of regulating cell-cell interactions in the resulting biological function of the tissues. Major conclusions: Patterned co-cultures are a useful tool for fabricating tissue engineered constructs and for studying cell-cell interactions in vitro, because they can be used to control the degree of homotypic and heterotypic cell-cell contact. In addition, this approach can be manipulated to elucidate important factors involved in cell-matrix interactions. General significance: Patterned co-culture strategies hold significant potential to develop biomimetic structures for tissue engineering. It is expected that they would create opportunities to develop artificial tissues in the future. This article is part of a Special Issue entitled Nanotechnologies - Emerging Applications in Biomedicine. © 2010 Elsevier B.V.

Published
2022

39. Organ-on-a-chip platforms for drug screening and delivery in tumor cells: a systematic review

Author

Gonçalves, Inês Maia Silva Rodrigo, Carvalho, Violeta Meneses, Rodrigues, Raquel Oliveira, Pinho, Diana, Teixeira, S. F. C. F., Moita, Ana, Hori, Takeshi, Kaji, Hirokazu, Lima, Rui Alberto Madeira Macedo, Minas, Graça, and Universidade do Minho

Subjects
Organoids, Cancer cells, Organ-on-a-chip, Science & Technology, Drug screening, Microfluidics, Drug delivery, Hard tissues and organs, Nanoparticles, Cell culture, Microbioreactor
Abstract

The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The combination of microfluidics and cell culture allows the design of a dynamic microenvironment suitable for the evaluation of treatments’ efficacy and effects, closer to the response observed in patients. This systematic review sums the studies from the last decade, where OoC with cancer cell cultures were used for drug screening assays. The studies were selected from three databases and analyzed following the research guidelines for systematic reviews proposed by PRISMA. In the selected studies, several types of cancer cells were evaluated, and the majority of treatments tested were standard chemotherapeutic drugs. Some studies reported higher drug resistance of the cultures on the OoC devices than on 2D cultures, which indicates the better resemblance to in vivo conditions of the former. Several studies also included the replication of the microvasculature or the combination of different cell cultures. The presence of vasculature can influence positively or negatively the drug efficacy since it contributes to a greater diffusion of the drug and also oxygen and nutrients. Co-cultures with liver cells contributed to the evaluation of the systemic toxicity of some drugs metabolites. Nevertheless, few studies used patient cells for the drug screening assays., This work has been supported by the projects NORTE-01-0145-FEDER-030171 (project reference PTDC/EME-SIS/30171/2017), NORTE-01-0145-FEDER-029394 (project reference PTDC/EMDEMD/29394/2017), through the COMPETE2020, the Lisb@2020, the Programa Operacional Regional do Norte–Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (FEDER) and by Fundação para a Ciência e Tecnologia (FCT), and through FEDER and FCT, project references EXPL/EMD-EMD/0650/2021 and PTDC/EEI-EEE/2846/2021. The authors also acknowledge the partial financial support within the R&D Units Project Scope: UIDB/00319/2020, UIDB/04077/2020, UIDB/00690/2020, UIDB/04436/2020. This work was also funded by AMED-CREST Grant Number JP20gm1310001h0002. Raquel O. Rodrigues (R.O.R.) thanks FCT for her contract funding provided through 2020.03975.CEECIND.

Published
2022

46. Microfabrication and Nanofabrication Techniques

Author

Ahadian, Samad, primary, Ostrovidov, Serge, additional, Fujie, Toshinori, additional, Parthiban, Selvakumar Prakash, additional, Kaji, Hirokazu, additional, Sampathkumar, Kaarunya, additional, Ramalingam, Murugan, additional, and Khademhosseini, Ali, additional

Published
2015
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47. List of Contributors

Author

Ahadian, Samad, primary, Akiyaman, Kentaro, additional, Alansari, Sarah, additional, Alikhani, Mani, additional, Alikhani, Mona, additional, Arthur, Agnieszka, additional, Arulkumar, Shylaja, additional, Baiguera, Silvia, additional, Bianco, Alessandra, additional, Bissada, Nabil F., additional, Bleicher, Françoise, additional, Bliley, Jacqueline M., additional, Bosshardt, Dieter D., additional, Botero, Tatiana M., additional, Braga, Raquel, additional, Briggs, Kristen K., additional, Brooks, Patricia J., additional, Cannon, Kevin, additional, Carrouel, Florence, additional, Chavez, Miquella G., additional, Cheng, Ming-Te, additional, Christ, George J., additional, Cook, Colin A., additional, Cooper, Paul R., additional, Cox, Timothy C., additional, Cunningham, Michael L., additional, Dashe, Jesse, additional, Davidovitch, Ze’ev, additional, Davies, Lindsay C., additional, Del Gaudio, Costantino, additional, Diekwisch, Thomas G.H., additional, Diogenes, Anibal, additional, Duncan, Randall L., additional, Edwards, Paul C., additional, El-Bialy, Tarek, additional, Enlow, Donald H., additional, Farach-Carson, Mary C., additional, Farges, Jean-Christophe, additional, Feinberg, Stephen E., additional, Felfy, Hady, additional, Freeman, Phillip N., additional, Freilich, Martin, additional, Fujie, Toshinori, additional, Gao, Changyou, additional, Giannobile, William V., additional, Gong, Siew-Ging, additional, Grayson, Warren L., additional, Greene, Robert M., additional, Gronthos, Stan, additional, Gruber, Reinhard, additional, Häkkinen, Lari, additional, Hanna, Craig, additional, Hargreaves, Kenneth M., additional, Satoshi, Emilio Hara, additional, Harrington, Daniel A., additional, Hashmi, Basma, additional, Heino, Jyrki, additional, Hing, Anne V., additional, Holmes, Christina, additional, Honda, Masaki J., additional, Horst, Jeremy A., additional, Hu, Michael S., additional, Hughes, Francis J., additional, Hung, Ben P., additional, Huri, Pinar Yilgor, additional, Ingber, Donald E., additional, Isokawa, Keitaro, additional, Izumi, Kenji, additional, James, Eric N., additional, Jia, Xinqiao, additional, Jin, Yan, additional, Emily Joo, E., additional, Juuri, Emma, additional, Kagami, Hideaki, additional, Kaji, Hirokazu, additional, Kang, Mo K., additional, Kashi, A., additional, Kato, Hiroko, additional, Kaur, Jasvir, additional, Keller, Letitia V., additional, Kemp, Paul D., additional, Khademhosseini, Ali, additional, Khoo, Edmund, additional, Kim, Hae-Won, additional, King, William J., additional, Kirschner, Richard E., additional, Klein, Ophir D., additional, Knowles, Jonathan C., additional, Koivisto, Leeni, additional, Kökten, Tunay, additional, Krebsbach, Paul H., additional, Kuboki, Takuo, additional, Kuchler-Bopp, Sabine, additional, Kucska, Simone, additional, Kuhn, Liisa, additional, Larjava, Hannu, additional, Lee, Eun-Jung, additional, Lee, Joo-Hee, additional, Lee, Oscar K., additional, Lee, Yoo Bin, additional, Lesot, Hervé, additional, Lewis, Mark P., additional, Li, Bei, additional, Li, Luyan, additional, Lim, Jung Yul, additional, Liu, Xing, additional, Liu, Xiaohua, additional, Lo, David D., additional, Longaker, Michael T., additional, Peter Lorenz, H., additional, Lott, David G., additional, Lungová, Vlasta, additional, Ma, Lie, additional, Macchiarini, Paolo, additional, Mammoto, Tadanori, additional, Marei, Mona K., additional, Marolt, Darja, additional, Marra, Kacey G., additional, Martin, Neil R.W., additional, Matalová, Eva, additional, Matsue, Tomokazu, additional, Mehrazarin, Shebli, additional, Mina, Mina, additional, Modo, Michel, additional, Mokry, Jaroslav, additional, Morsczeck, Christian, additional, Moussa, Rania M., additional, Murphy, Neal C., additional, Mushegyan, Vagan, additional, Nagy, Naglaa B., additional, Nair, Lakshmi S., additional, Nayar, Harry, additional, Nör, Jacques E., additional, Obregón, Raquel, additional, Oh, Tae-Ju, additional, Oka, Kyoko, additional, Ostrovidov, Serge, additional, Park, No-Hee, additional, Passineau, Michael J., additional, Passipieri, Juliana A., additional, Pisal, Rishikaysh, additional, Player, Darren, additional, Pradhan-Bhatt, Swati, additional, Parthiban, Selvakumar Prakash, additional, Prochazka, Jan, additional, Prochazkova, Michaela, additional, Qu, Tiejun, additional, Ramalingam, Murugan, additional, Ramón-Azcón, Javier, additional, Rana, Deepti, additional, Ray, Herbert L., additional, Reed, David A., additional, Reinhardt, Dieter P., additional, Richard, Béatrice, additional, Riehl, Brandon D., additional, Rios, Hector F., additional, Peter Rubin, J., additional, Saad, Manal M., additional, Sachar, Ashneet, additional, Sah, Robert L., additional, Saha, Subrata, additional, Saito, Yoko, additional, Sampathkumar, Kaarunya, additional, Sangsuwon, Chinapa, additional, Seo, Byoung Moo, additional, Sharpe, Paul, additional, Shi, Songtao, additional, Shih, Yu-Ru V., additional, Shiku, Hitoshi, additional, Shin, Seung Yun, additional, Sjöqvist, Sebastian, additional, Sloan, Alastair J., additional, Smith, Anthony (Tony) J., additional, Song, In Seok, additional, Stephens, Neil, additional, Stephens, Phil, additional, Svoboda, Kathy K.H., additional, Tabrizian, Maryam, additional, Teixeira, Cristina, additional, Teixeira, Fabricio B., additional, Temple, Joshua P., additional, Thesleff, Irma, additional, Thivichon-Prince, Béatrice, additional, Toriumi, Taku, additional, Treasure, Trevor E., additional, Um, Soyoun, additional, Vishwakarma, Ajaykumar, additional, Wang, Chunfen, additional, Watson, Deborah, additional, Watson, Jeffrey B., additional, Wen, Bo, additional, Witt, Robert L., additional, Wong, Mark E., additional, Yamada, Kenneth M., additional, Yassin, Hala H., additional, Zakheim, Daniel, additional, Zhang, Bing, additional, and Zimmermann, Andrew S., additional

Published
2015
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