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2. Supplementary Figure S1 from Treatment with Chemotherapy and Dendritic Cells Pulsed with Multiple Wilms' Tumor 1 (WT1)–Specific MHC Class I/II–Restricted Epitopes for Pancreatic Cancer

Author

Koido, Shigeo, primary, Homma, Sadamu, primary, Okamoto, Masato, primary, Takakura, Kazuki, primary, Mori, Masako, primary, Yoshizaki, Shinji, primary, Tsukinaga, Shintaro, primary, Odahara, Shunichi, primary, Koyama, Seita, primary, Imazu, Hiroo, primary, Uchiyama, Kan, primary, Kajihara, Mikio, primary, Arakawa, Hiroshi, primary, Misawa, Takeyuki, primary, Toyama, Yoichi, primary, Yanagisawa, Satoru, primary, Ikegami, Masahiro, primary, Kan, Shin, primary, Hayashi, Kazumi, primary, Komita, Hideo, primary, Kamata, Yuko, primary, Ito, Masaki, primary, Ishidao, Takefumi, primary, Yusa, Sei-ichi, primary, Shimodaira, Shigetaka, primary, Gong, Jianlin, primary, Sugiyama, Haruo, primary, Ohkusa, Toshifumi, primary, and Tajiri, Hisao, primary

Published
2023
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3. Supplementary Table S1 from Treatment with Chemotherapy and Dendritic Cells Pulsed with Multiple Wilms' Tumor 1 (WT1)–Specific MHC Class I/II–Restricted Epitopes for Pancreatic Cancer

Author

Koido, Shigeo, primary, Homma, Sadamu, primary, Okamoto, Masato, primary, Takakura, Kazuki, primary, Mori, Masako, primary, Yoshizaki, Shinji, primary, Tsukinaga, Shintaro, primary, Odahara, Shunichi, primary, Koyama, Seita, primary, Imazu, Hiroo, primary, Uchiyama, Kan, primary, Kajihara, Mikio, primary, Arakawa, Hiroshi, primary, Misawa, Takeyuki, primary, Toyama, Yoichi, primary, Yanagisawa, Satoru, primary, Ikegami, Masahiro, primary, Kan, Shin, primary, Hayashi, Kazumi, primary, Komita, Hideo, primary, Kamata, Yuko, primary, Ito, Masaki, primary, Ishidao, Takefumi, primary, Yusa, Sei-ichi, primary, Shimodaira, Shigetaka, primary, Gong, Jianlin, primary, Sugiyama, Haruo, primary, Ohkusa, Toshifumi, primary, and Tajiri, Hisao, primary

Published
2023
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5. Clinical features, therapeutic outcomes, and recovery period of long COVID.

Author

Takakura, Kazuki, Suka, Machi, Kajihara, Mikio, and Koido, Shigeo

Subjects
POST-acute COVID-19 syndrome, FATIGUE (Physiology), BALDNESS, TREATMENT delay (Medicine), TREATMENT effectiveness, JOINT pain, ALOPECIA areata
Abstract

To characterize the clinical features of long COVID, 286 patients who received care in our outpatient clinic for long COVID from May to December 2021 were surveyed. The recovery periods of each symptom and the key factors contributing to early recovery were statistically analysed. The median age of the patients was 35.8 years, with 137 men and 149 women. The median number of symptoms was 2.8. The most frequent symptoms were respiratory manifestations (52.1%), followed by fatigue (51.4%). Respiratory symptoms, fatigue, and headache/arthralgia were major complaints in the initial phase, whereas hair loss was a major complaint in the late phase, suggesting that the chief complaint of patients with long COVID may vary temporally. The best treatment outcome was observed for pulmonary symptoms, and hair loss had the worst outcome. COVID‐19 severity, the number of manifestations, and the delay in starting treatment exerted a negative effect on the recovery period of long COVID. In addition, the smoking habit was an independent risk factor for slowing the recovery period from long COVID. This study provides insights into the clinical course of each manifestation and therapeutic options with a more certain future of long COVID to meet the unmet medical needs. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Role of ICAM-1 in chronic ethanol consumption-enhanced liver injury after gut ischemia-reperfusion in rats

Author

Horie, Yoshinori, Yamagishi, Yoshiyuki, Kato, Shinzo, Kajihara, Mikio, Tamai, Hironao, Granger, D. Neil, and Ishii, Hiromasa

Subjects
Molecular biology -- Research, Cell adhesion molecules -- Physiological aspects, Liver -- Wounds and injuries, Leukocytes -- Physiological aspects, Cell adhesion -- Physiological aspects, Endotoxins -- Physiological aspects, Microcirculation -- Physiological aspects, Cytokines -- Physiological aspects, Reperfusion injury -- Physiological aspects, Drinking of alcoholic beverages -- Physiological aspects, Biological sciences
Abstract

Intercellular adhesion molecule-1 (ICAM-1) has been implicated in the hepatic microvascular dysfunction elicited by gut ischemia-reperfusion (I/R). Although the effects of chronic ethanol (EtOH) consumption on the liver are well known, it remains unclear whether this condition renders the hepatic microcirculation more vulnerable to the deleterious effects of gut and/or hepatic I/R. The objectives of this study were to determine whether chronic EtOH consumption alters the severity of gut I/R-induced hepatic microvascular dysfunction and hepatocellular injury and to determine whether ICAM-1 contributes to this response. Male Wistar rats, pair fed for 6 wk a liquid diet containing EtOH or an isocaloric control diet, were exposed to gut I/R. Intravital video microscopy was used to monitor leukocyte recruitment in the hepatic microcirculation, the number of nonperfused sinusoids (NPS), and plasma concentrations of endotoxin and tumor necrosis factor-[alpha]. Plasma alanine aminotransferase (ALT) levels were measured 6 h afar the onset of reperfusion. In control rats, gut I/R elicited increases in the number of stationary leukocytes, NPS, and plasma endotoxin, tumor necrosis factor-n, and ALT. In EtOH-fed rats, the gut I/R-induced increases in NPS and leukostasis were blunted in the midzonal region, while exaggerated leukostasis was noted in the pericentral region and terminal hepatic venules. Chronic EtOH consumption also enhanced the gut I/R-induced increase in plasma endotoxin and ALT. The exaggerated responses to gut I/R normally seen in EtOH-fed rats were largely prevented by pretreatment with a blocking anti-ICAM-1 monoclonal antibody. In conclusion, these results suggest that chronic EtOH consumption enhances gut I/R-induced hepatic microvascular dysfunction and hepatocellular injury in the pericentral region and terminal hepatic venules via an enhanced hepatic expression of ICAM-1. leukocyte adhesion; adhesion molecule; endotoxin; microcirculation; cytokine

Published
2002

7. Ethanol modulates gut ischemia/reperfusion-induced liver injury in rats

Author

Yamagishi, Yoshiyuki, Horie, Yoshinori, Kato, Shinzo, Kajihara, Mikio, Tamai, Hironao, Granger, D. Neil, and Ishii, Hiromasa

Subjects
Hypoxia -- Physiological aspects, Intestinal ischemia -- Physiological aspects, Alcohol -- Physiological aspects, Biological sciences
Abstract

Whereas both ethanol and gut ischemia/reperfusion (I/R) are known to alter hepatic microvascular function, little is known about the influence of ethanol consumption on the hepatic microvascular responses to I/R. The objective of this study was to determine whether acute ethanol administration exacerbates the hepatic microvascular dysfunction induced by gut I/R. Rats were exposed to gut ischemia for 30 min followed by reperfusion. Intravital videomicroscopy was used to monitor leukocyte recruitment and the number of nonperfused sinusoids (NPS). Plasma alanine aminotransferase (ALT), tumor necrosis factor-[alpha] (TNF-[alpha]), and endotoxin concentrations were monitored. In separate experiments, ethanol was administered 15 min or 24 h before gut ischemia. In control rats, gut I/R increased the number of stationary leukocytes and NPS. It also elevated the plasma ALT, TNF-[alpha], and endotoxin with a corresponding increase in intestinal mucosal permeability. Low-dose ethanol consumption 15 min before gut ischemia blunted the gut I/R-induced leukostasis and elevations in plasma TNF-[alpha] and ALT. However, high-dose ethanol consumption aggravated the gut I/R-induced increases in leukostasis and increases in plasma endotoxin and ALT. When ethanol was administered 24 h before, high-dose ethanol aggravated the gut I/R-induced hepatocellular injury, but low-dose ethanol did not have any effects on it. These results suggest that low-dose ethanol consumption shortly before gut ischemia attenuates the hepatic inflammatory responses, microvascular dysfunction, and hepatocellular injury elicited by gut I/R, whereas high-dose ethanol consumption appears to significantly aggravate these gut I/R-induced responses. tissue hypoxia; intravital microscopy; intestinal mucosal permeability; tumor necrosis factor-[alpha]; endotoxin.

Published
2002

19. Colon metastasis of renal cell carcinoma with sarcomatoid change: a case report

Author

Homma, Satoshi, primary, Arakawa, Hiroshi, additional, Ohno, Yuki, additional, Ban, Yamato, additional, Koyama, Seita, additional, Adachi, Sei, additional, Hoshino, Atsushi, additional, Ito, Zensho, additional, Matsumoto, Yoshihiro, additional, Kajihara, Mikio, additional, Uchiyama, Kan, additional, Koido, Kaoru, additional, and Sumiyama, Kazuki, additional

Published
2019
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20. Metagenomic analyses of the gut microbiota associated with colorectal adenoma

Author

Saito, Keisuke, primary, Koido, Shigeo, additional, Odamaki, Toshitaka, additional, Kajihara, Mikio, additional, Kato, Kumiko, additional, Horiuchi, Sankichi, additional, Adachi, Sei, additional, Arakawa, Hiroshi, additional, Yoshida, Sayumi, additional, Akasu, Takafumi, additional, Ito, Zensho, additional, Uchiyama, Kan, additional, Saruta, Masayuki, additional, Xiao, Jin-zhong, additional, Sato, Nobuhiro, additional, and Ohkusa, Toshifumi, additional

Published
2019
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21. Prognostic significance of Wilms' tumor 1 expression in patients with pancreatic ductal adenocarcinoma

Author

Kanai, Tomoya, primary, Ito, Zensho, additional, Oji, Yusuke, additional, Suka, Machi, additional, Nishida, Sumiyuki, additional, Takakura, Kazuki, additional, Kajihara, Mikio, additional, Saruta, Masayuki, additional, Fujioka, Shuichi, additional, Misawa, Takeyuki, additional, Akiba, Tadashi, additional, Yanagisawa, Hiroyuki, additional, Shimodaira, Shigetaka, additional, Okamoto, Masato, additional, Sugiyama, Haruo, additional, and Koido, Shigeo, additional

Published
2018
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22. Prognostic impact of carbohydrate sulfotransferase 15 in patients with pancreatic ductal adenocarcinoma

Author

Ito, Zensho, primary, Takakura, Kazuki, additional, Suka, Machi, additional, Kanai, Tomoya, additional, Saito, Ryota, additional, Fujioka, Shuichi, additional, Kajihara, Mikio, additional, Yanagisawa, Hiroyuki, additional, Misawa, Takeyuki, additional, Akiba, Tadashi, additional, Koido, Shigeo, additional, and Ohkusa, Toshifumi, additional

Published
2017
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23. Characterisation of blood microbiota in patients with liver cirrhosis.

Author

Mikio Kajihara, Shigeo Koido, Tomoya Kana, Zensho Ito, Yoshihiro Matsumoto, Kazuki Takakura, Masayuki Saruta, Kumiko Kato, Toshitaka Odamak, Jin-zhong Xiao, Nobuhiro Sato, Toshifumi Ohkusa, Kajihara, Mikio, Koido, Shigeo, Kanai, Tomoya, Ito, Zensho, Matsumoto, Yoshihiro, Takakura, Kazuki, Saruta, Masayuki, and Kato, Kumiko

Published
2019
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24. Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1.

Author

Ito, Zensho, Kan, Shin, Bito, Tsuuse, Horiuchi, Sankichi, Akasu, Takafumi, Yoshida, Sayumi, Kajihara, Mikio, Hokari, Atsushi, Saruta, Masayuki, Yoshida, Noriyuki, Kobayashi, Masanori, Ohkusa, Toshifumi, Shimodaira, Shigetaka, Okamoto, Masato, Sugiyama, Haruo, and Koido, Shigeo

Subjects
THERAPEUTIC use of antimetabolites, ADENOCARCINOMA, BIOMARKERS, CANCER chemotherapy, CANCER patients, CLINICAL trials, DENDRITIC cells, GRANULOCYTES, NEPHROBLASTOMA, PANCREATIC tumors, SURVIVAL, TUMOR markers, CANCER vaccines, MATRIX metalloproteinases
Abstract

Background: We have developed a Wilms' tumor 1 (WT1)-targeting dendritic cell (DC)-based cancer vaccine combined with standard chemotherapy for patients with advanced pancreatic ductal adenocarcinoma (PDA). Methods: We evaluated predictive markers of overall survival (OS) in PDA patients treated with multiple major histocompatibility complex class I/II-restricted, WT1 peptide-pulsed DC vaccinations (DC/WT1-I/II) in combination with chemotherapy. Throughout the entire period of immunochemotherapy, the plasma levels of soluble factors derived from granulocytes of 7 eligible PDA patients were examined. Moreover, systemic inflammatory response markers (neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], and granulocyte-to-lymphocyte ratio [GLR]) were assessed. In addition, cytoplasmic WT1 expression in PDA cells was examined. Results: Compared to the 4 non-super-responders (OS <1 year), the remaining 3 super-responders (OS ≥1 year) showed significantly decreased low plasma matrix metalloproteinase-9 levels throughout long-term therapy. The NLR, MLR, and GLR after 5 DC/WT1-I/II vaccinations and 3 cycles of gemcitabine were significantly lower in the super-responders than in the non-super-responders. Furthermore, the cytoplasmic WT1 expression in the PDA cells of super-responders was relatively weak compared to that in the PDA cells of non-super-responders. Conclusions: Prolonged low levels of a granulocyte-related systemic inflammatory response after the early period of therapy and low cytoplasmic WT1 expression in PDA cells may be markers predictive of OS in PDA patients receiving WT1-targeting immunochemotherapy. [ABSTRACT FROM AUTHOR]

Published
2019
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25. Hepatic Angiosarcoma Associated with Esophageal Variceal Hemorrhage

Author

Ito, Zensho, primary, Kajihara, Mikio, additional, Kobayashi, Yasunobu, additional, Kanai, Tomoya, additional, Matsumoto, Yoshihiro, additional, Takakura, Kazuki , additional, Yukawa, Toyokazu , additional, Ohkusa, Toshifumi, additional, Koyama, Seita, additional, Imazu, Hiroo, additional, Arakawa, Hiroshi, additional, Ohata, Mitsuru, additional, and Koido, Shigeo, additional

Published
2016
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26. Dendritic cell-based cancer immunotherapy for colorectal cancer

Author

Kajihara, Mikio, primary, Takakura, Kazuki, additional, Kanai, Tomoya, additional, Ito, Zensho, additional, Saito, Keisuke, additional, Takami, Shinichiro, additional, Shimodaira, Shigetaka, additional, Okamoto, Masato, additional, Ohkusa, Toshifumi, additional, and Koido, Shigeo, additional

Published
2016
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28. Comprehensive assessment of the prognosis of pancreatic cancer: peripheral blood neutrophil–lymphocyte ratio and immunohistochemical analyses of the tumour site

Author

Takakura, Kazuki, primary, Ito, Zensho, additional, Suka, Machi, additional, Kanai, Tomoya, additional, Matsumoto, Yoshihiro, additional, Odahara, Shunichi, additional, Matsudaira, Hiroshi, additional, Haruki, Koichiro, additional, Fujiwara, Yuki, additional, Saito, Ryota, additional, Gocho, Takeshi, additional, Nakashiro, Koh-Ichi, additional, Hamakawa, Hiroyuki, additional, Okamoto, Masato, additional, Kajihara, Mikio, additional, Misawa, Takeyuki, additional, Ohkusa, Toshifumi, additional, and Koido, Shigeo, additional

Published
2015
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29. Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model

Author

Takakura, Kazuki, primary, Shibazaki, Yuichiro, additional, Yoneyama, Hiroyuki, additional, Fujii, Masato, additional, Hashiguchi, Taishi, additional, Ito, Zensho, additional, Kajihara, Mikio, additional, Misawa, Takeyuki, additional, Homma, Sadamu, additional, Ohkusa, Toshifumi, additional, and Koido, Shigeo, additional

Published
2015
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30. Effectiveness of Antibiotic Combination Therapy Targeting Intestinal Bacteria for Ulcerative Colitis

Author

Kobayashi, Hiroko, primary, Tsukinaga, Shintaro, additional, Kanai, Tomoya, additional, Takami, Shinichiro, additional, Saito, Keisuke, additional, Ito, Zensho, additional, Takakura, Kazuki, additional, Matsumoto, Yoshihiro, additional, Yukawa, Toyokazu, additional, Odahara, Shunichi, additional, Uchiyama, Kan, additional, Kajihara, Mikio, additional, Arakawa, Hiroshi, additional, Koido, Shigeo, additional, and Ohkusa, Toshifumi, additional

Published
2015
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31. Fusobacteria Detected in Colonoscopy Aspirates of Colon Cancer and Adenoma

Author

Saito, Keisuke, primary, Kobayashi, Hiroko, additional, Kanai, Tomoya, additional, Takami, Shinichiro, additional, Ito, Zensho, additional, Tsukinaga, Shintaro, additional, Takakura, Kazuki, additional, Matsumoto, Yoshihiro, additional, Yukawa, Toyokazu, additional, Adachi, Sei, additional, Odahara, Shunichi, additional, Uchiyama, Kan, additional, Kajihara, Mikio, additional, Arakawa, Hiroshi, additional, Koido, Shigeo, additional, and Ohkusa, Toshifumi, additional

Published
2015
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33. Abstract CT223: Dendritic cells pulsed with Wilms′ tumor gene 1 (WT1)-specific and MHC class I and II-restricted epitopes with gemcitabine induce antitumor immune responses in patients with advanced pancreatic cancer

Author

Koido, Shigeo, primary, Homma, Sadamu, additional, Okamoto, Masato, additional, Mori, Masako, additional, Yoshizaki, Shinji, additional, Takakura, Kazuki, additional, Hayashi, Kazumi, additional, Kan, Shin, additional, Ishidao, Takafumi, additional, Yusa, Sei-ichi, additional, Shimodaira, Shigetaka, additional, Uchiyama, Kan, additional, Kajihara, Mikio, additional, Imazu, Hiroo, additional, Arakawa, Hiroshi, additional, Ohkusa, Toshifumi, additional, and Tajiri, Hisao, additional

Published
2014
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34. Treatment with Chemotherapy and Dendritic Cells Pulsed with Multiple Wilms' Tumor 1 (WT1)–Specific MHC Class I/II–Restricted Epitopes for Pancreatic Cancer

Author

Koido, Shigeo, primary, Homma, Sadamu, additional, Okamoto, Masato, additional, Takakura, Kazuki, additional, Mori, Masako, additional, Yoshizaki, Shinji, additional, Tsukinaga, Shintaro, additional, Odahara, Shunichi, additional, Koyama, Seita, additional, Imazu, Hiroo, additional, Uchiyama, Kan, additional, Kajihara, Mikio, additional, Arakawa, Hiroshi, additional, Misawa, Takeyuki, additional, Toyama, Yoichi, additional, Yanagisawa, Satoru, additional, Ikegami, Masahiro, additional, Kan, Shin, additional, Hayashi, Kazumi, additional, Komita, Hideo, additional, Kamata, Yuko, additional, Ito, Masaki, additional, Ishidao, Takefumi, additional, Yusa, Sei-ichi, additional, Shimodaira, Shigetaka, additional, Gong, Jianlin, additional, Sugiyama, Haruo, additional, Ohkusa, Toshifumi, additional, and Tajiri, Hisao, additional

Published
2014
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35. Repetitive acute cholangitis and pancreatitis due to Lemmel syndrome: A case report

Author

Takakura, Kazuki, primary, Koido, Shigeo, additional, Kajihara, Mikio, additional, Fukue, Ryosuke, additional, Takami, Shinichiro, additional, Ito, Zensho, additional, Kobayashi, Hiroko, additional, Matsumoto, Yoshihiro, additional, Tsukinaga, Shintaro, additional, Odahara, Shunichi, additional, Yukawa, Toyokazu, additional, Uchiyama, Kan, additional, Misawa, Takeyuki, additional, Ohkusa, Toshifumi, additional, and Tajiri, Hisao, additional

Published
2014
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36. Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells

Author

KOIDO, SHIGEO, primary, HOMMA, SADAMU, additional, KAN, SHIN, additional, TAKAKURA, KAZUKI, additional, NAMIKI, YOSHIHISA, additional, KOBAYASHI, HIROKO, additional, ITO, ZENSHO, additional, UCHIYAMA, KAN, additional, KAJIHARA, MIKIO, additional, ARIHIRO, SEIJI, additional, ARAKAWA, HIROSHI, additional, OKAMOTO, MASATO, additional, OHKUSA, TOSHIFUMI, additional, GONG, JIANLIN, additional, and TAJIRI, HISAO, additional

Published
2014
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38. Edwardsiella tarda Superinfection in Relapse of Ulcerative Colitis

Author

Koido, Shigeo, primary, Ohkusa, Toshifumi, additional, Kato, Kimitoshi, additional, Shimamoto, Nana, additional, Takakura, Kazuki, additional, Odahara, Shunichi, additional, Tsukinaga, Shintaro, additional, Mitobe, Jimi, additional, Yukawa, Toyokazu, additional, Kajihara, Mikio, additional, Uchiyama, Kan, additional, Arakawa, Hiroshi, additional, and Tajiri, Hisao, additional

Published
2014
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39. Long-Term Alteration of Intestinal Microbiota in Patients with Ulcerative Colitis by Antibiotic Combination Therapy

Author

Koido, Shigeo, primary, Ohkusa, Toshifumi, additional, Kajiura, Takayuki, additional, Shinozaki, Junko, additional, Suzuki, Manabu, additional, Saito, Keisuke, additional, Takakura, Kazuki, additional, Tsukinaga, Shintaro, additional, Odahara, Shunichi, additional, Yukawa, Toyokazu, additional, Mitobe, Jimi, additional, Kajihara, Mikio, additional, Uchiyama, Kan, additional, Arakawa, Hiroshi, additional, and Tajiri, Hisao, additional

Published
2014
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41. Correlation between endoscopic healing and histological healing of ulcerative colitis determined using the Mayo score

Author

Adachi, Sei, primary, Arakawa, Hiroshi, additional, Koyama, Seita, additional, Saito, Keisuke, additional, Ito, Zensho, additional, Matsumoto, Yoshihiro, additional, Takakura, Kazuki, additional, Tsukinaga, Shintaro, additional, Odahara, Shunichi, additional, Yukawa, Toyokazu, additional, Kajihara, Mikio, additional, Uchiyama, Kan, additional, Koido, Shigeo, additional, Ohkusa, Toshifumi, additional, and Tajiri, Hisao, additional

Published
2014
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42. Long-term management of gemcitabine in a patient with advanced pancreatic cancer undergoing haemodialysis

Author

Takakura, Kazuki, primary, Koido, Shigeo, additional, Takahara, Akitaka, additional, Odahara, Shunichi, additional, Mitobe, Jimi, additional, Matsudaira, Hiroshi, additional, Tsukinaga, Shintaro, additional, Yukawa, Toyokazu, additional, Matsumoto, Kei, additional, Nagatsuma, Keisuke, additional, Uchiyama, Kan, additional, Kajihara, Mikio, additional, Ohkusa, Toshifumi, additional, and Tajiri, Hisao, additional

Published
2013
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43. Unusual Images of Mass-Forming Intrahepatic Cholangiocarcinoma

Author

Takakura, Kazuki, primary, Kajihara, Mikio, additional, Iwasaki, Tetsuyoshi, additional, Ide, Daisuke, additional, Miyazaki, Tamihiro, additional, Arai, Yoshinori, additional, Saruta, Masayuki, additional, Arihiro, Seiji, additional, Matsuoka, Mika, additional, Koido, Shigeo, additional, Ito, Ryusuke, additional, Matsumoto, Michinori, additional, Gocho, Takeshi, additional, Wakiyama, Shigeki, additional, Yanaga, Katsuhiko, additional, and Tajiri, Hisao, additional

Published
2013
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44. Strategies to improve the immunogenicity of anticancer vaccines based on dendritic cell/malignant cell fusions

Author

koido, shigeo, primary, Homma, Sadamu, additional, Okamoto, Masato, additional, Namiki, Yoshihisa, additional, Takakura, Kazuki, additional, Uchiyama, Kan, additional, Kajihara, Mikio, additional, Arihiro, Seiji, additional, Imazu, Hiroo, additional, Arakawa, Hiroshi, additional, Kan, Shin, additional, Komita, Hideo, additional, Kamata, Yuko, additional, Ito, Masaki, additional, Ohkusa, Toshifumi, additional, Gong, Jianlin, additional, and Tajiri, Hisao, additional

Published
2013
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45. Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation

Author

Koido, Shigeo, primary, Homma, Sadamu, additional, Okamoto, Masato, additional, Namiki, Yoshihisa, additional, Kan, Shin, additional, Takakura, Kazuki, additional, Kajihara, Mikio, additional, Uchiyama, Kan, additional, Hara, Eiich, additional, Ohkusa, Toshifumi, additional, Gong, Jianlin, additional, and Tajiri, Hisao, additional

Published
2013
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47. Augmentation of Antitumor Immunity by Fusions of Ethanol-Treated Tumor Cells and Dendritic Cells Stimulated via Dual TLRs through TGF-β1 Blockade and IL-12p70 Production

Author

Koido, Shigeo, primary, Homma, Sadamu, additional, Okamoto, Masato, additional, Namiki, Yoshihisa, additional, Takakura, Kazuki, additional, Takahara, Akitaka, additional, Odahara, Shunichi, additional, Tsukinaga, Shintaro, additional, Yukawa, Toyokazu, additional, Mitobe, Jimi, additional, Matsudaira, Hiroshi, additional, Nagatsuma, Keisuke, additional, Kajihara, Mikio, additional, Uchiyama, Kan, additional, Arihiro, Seiji, additional, Imazu, Hiroo, additional, Arakawa, Hiroshi, additional, Kan, Shin, additional, Hayashi, Kazumi, additional, Komita, Hideo, additional, Kamata, Yuko, additional, Ito, Masaki, additional, Hara, Eiichi, additional, Ohkusa, Toshifumi, additional, Gong, Jianlin, additional, and Tajiri, Hisao, additional

Published
2013
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48. Tu1887 Fusions Cells Generated With Combined TLR2/4-Activated Dendritic Cells and Tumor Cells Induce Efficient Antigen-Specific Cytotoxic T Lymphocytes Through IL-12p70 Production

Author

Takakura, Kazuki, primary, Koido, Shigeo, additional, Homma, Sadamu, additional, Takahara, Akitaka, additional, Odahara, Shunichi, additional, Tsukinaga, Shintaro, additional, Mitobe, Jimi, additional, Yukawa, Toyokazu, additional, Matsudaira, Hiroshi, additional, Nagatsuma, Keisuke, additional, Komita, Hideo, additional, Uchiyama, Kan, additional, Kajihara, Mikio, additional, Imazu, Hiroo, additional, Arakawa, Hiroshi, additional, Ohkusa, Toshifumi, additional, and Tajiri, Hisao, additional

Published
2013
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49. Fusions between dendritic cells and whole tumor cells as anticancer vaccines

Author

Koido, Shigeo, primary, Homma, Sadamu, additional, Okamoto, Masato, additional, Namiki, Yoshihisa, additional, Takakura, Kazuki, additional, Uchiyama, Kan, additional, Kajihara, Mikio, additional, Arihiro, Seiji, additional, Imazu, Hiroo, additional, Arakawa, Hiroshi, additional, Kan, Shin, additional, Komita, Hideo, additional, Ito, Masaki, additional, Ohkusa, Toshifumi, additional, Gong, Jianlin, additional, and Tajiri, Hisao, additional

Published
2013
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50. Comprehensive assessment of the prognosis of pancreatic cancer: peripheral blood neutrophil–lymphocyte ratio and immunohistochemical analyses of the tumour site.

Author

Takakura, Kazuki, Ito, Zensho, Suka, Machi, Kanai, Tomoya, Matsumoto, Yoshihiro, Odahara, Shunichi, Matsudaira, Hiroshi, Haruki, Koichiro, Fujiwara, Yuki, Saito, Ryota, Gocho, Takeshi, Nakashiro, Koh-Ichi, Hamakawa, Hiroyuki, Okamoto, Masato, Kajihara, Mikio, Misawa, Takeyuki, Ohkusa, Toshifumi, and Koido, Shigeo

Subjects
NEUTROPHILS, LYMPHOCYTES, IMMUNOHISTOCHEMISTRY, CANCER patients, PANCREATIC cancer, SURGICAL excision, PROGNOSIS
Abstract

ObjectiveSeveral studies have suggested that an elevated neutrophil–lymphocyte ratio (NLR) is associated with a poorer prognosis in patients with pancreatic cancer (PC). The correlations between the NLR and immunohistochemical (IHC) analysis with regard to the prognosis of patients with PC remain to be elucidated. By using IHC findings, we determined the value of the NLR as a prognostic factor in patients with PC.Material and methodsWe collected the clinico-pathological data of 28 consecutive patients who underwent surgical resection for PC between January 2008 and December 2012 at The Jikei University Kashiwa Hospital. We investigated whether the NLR and IHC results were related and ensured the consistency of the prognosis of patients with PC.ResultsThe Kaplan–Meier curves for the disease-free survival (DFS) and the overall survival (OS) revealed that an NLR ≥ 5 is an implicit factor for decreased DFS and OS in patients with PC (p = 0.003,p < 0.001, log-rank test). The density of CD163+ macrophages and CD66b+ neutrophils was significantly higher in the high NLR group; on the contrary, the density of CD20+ lymphocytes was significantly higher in the low NLR group. Moreover, a Mann–WhitneyUtest showed that the NLR was significantly correlated with a high density of CD20+ lymphocytes (p = 0.031) and CD163+ macrophages (p = 0.023), while the NLR was not significantly correlated with CD66b+ neutrophils (p = 0.397).ConclusionsOur results demonstrated the validity of the NLR by IHC analyses and we determined that a higher value of NLR is a trustworthy prognostic factor for patients with PC. [ABSTRACT FROM AUTHOR]

Published
2016
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