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Your search keyword '"Kajiwara, Masatoshi"' showing total 43 results
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43 results on '"Kajiwara, Masatoshi"'

9. Efficacy of laparoscopic liver resection for small hepatocellular carcinoma located in the posterosuperior segments: A multi‐institutional study using propensity score matching by the Kyushu Study Group of Liver Surgery

Author

Tokumitsu, Yukio, primary, Nagano, Hiroaki, additional, Yamashita, Yo‐ichi, additional, Yoshizumi, Tomoharu, additional, Hisaka, Toru, additional, Nanashima, Atsushi, additional, Kuroki, Tamotsu, additional, Ide, Takao, additional, Endo, Yuichi, additional, Utsunomiya, Tohru, additional, Kitahara, Kenji, additional, Kawasaki, Yota, additional, Sakota, Masahiko, additional, Okamoto, Kohji, additional, Takami, Yuko, additional, Kajiwara, Masatoshi, additional, Takatsuki, Mitsuhisa, additional, Beppu, Toru, additional, and Eguchi, Susumu, additional

Published
2023
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13. Risk Factors of Complications from Central Bisectionectomy (H458) for Hepatocellular Carcinoma: A Multi-Institutional Single-Arm Analysis

Author

Nanashima, Atsushi, primary, Eguchi, Susumu, additional, Hisaka, Toru, additional, Kawasaki, Yota, additional, Yamashita, Yo-ichi, additional, Ide, Takao, additional, Kuroki, Tamotsu, additional, Yoshizumi, Tomoharu, additional, Kitahara, Kenji, additional, Endo, Yuichi, additional, Utsunomiya, Tohru, additional, Kajiwara, Masatoshi, additional, Sakoda, Masahiko, additional, Okamoto, Kohji, additional, Nagano, Hiroaki, additional, Takami, Yuko, additional, and Beppu, Toru, additional

Published
2023
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19. Standardized Methods Using EUS-guided Fine-needle Biopsy and a Minimal Medium Creates Three Pancreatic Cancer Organoids

Author

ISHIDA, YUSUKE, primary, TSUNODA, TOSHIYUKI, additional, HAMADA, YOSHIHIRO, additional, TSUCHIYA, NAOAKI, additional, KOGA, TAKEHIKO, additional, KITAGUCHI, TAKANORI, additional, MATSUMOTO, KEISUKE, additional, MATSUMOTO, SHINJI, additional, SASAKI, TAKAHIDE, additional, NAKASHIMA, RYO, additional, ISHII, FUMINORI, additional, KAJIWARA, MASATOSHI, additional, SHIRASAWA, SENJI, additional, HASEGAWA, SUGURU, additional, and HIRAI, FUMIHITO, additional

Published
2022
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27. Impact of AirSeal® insufflation system on respiratory and circulatory dynamics during laparoscopic abdominal surgery.

Author

Kajiwara, Masatoshi, Nakashima, Ryo, Yoshimura, Fumihiro, and Hasegawa, Suguru

Abstract

The effect of the AirSeal® insufflation system on hemodynamic parameters, especially end-tidal carbon dioxide (EtCO2), during laparoscopic abdominal surgery remains unclear. This retrospective single-center study included 333 consecutive patients who underwent laparoscopic hepatectomy (n = 43), gastrectomy (n = 69), colectomy (n = 137), or proctectomy (n = 84) using the AirSeal®. Patient demographics and intraoperative hemodynamic parameters, such as EtCO2, peripheral capillary oxygen saturation (SpO2), and arterial systolic blood pressure (ABP), were collected and analyzed. EtCO2 was evaluated during the entire operative period (whole period) as well as the pneumoperitoneum period until specimen removal (pneumoperitoneum period). We defined "positive respiratory and circulatory responses" (positive responses) as a decrease in EtCO2 ≥ 3 mmHg in addition to decreases in SpO2 ≥ 3% and ABP ≥ 10 mmHg simultaneously, which suggest possible carbon dioxide (CO2) embolism. The median EtCO2 values of hepatectomy, gastrectomy, colectomy, and proctectomy in the whole period/pneumoperitoneum period were 37.3/37.4, 37.1/37.3, 37.4/37.9, and 38.2/38.4 mmHg, respectively. The EtCO2 of proctectomy was significantly higher than that of gastrectomy during the whole and pneumoperitoneum periods (P < 0.05). In contrast, the EtCO2 of hepatectomy was comparable to that of the other three surgeries in the whole and pneumoperitoneum periods. Meanwhile, nine (2.7%; eight hepatectomies and one proctectomy) patients showed positive responses, and one who underwent a partial hepatectomy developed a clinically manifested CO2 embolism. Positive responses occurred during venous exposure or bleeding in all nine cases. Although the EtCO2 of hepatectomy was comparable to that of the other surgeries using the AirSeal®, laparoscopic hepatectomy showed a tendency of CO2 embolism. Thus, a secure and careful surgical approach is mandatory for laparoscopic hepatectomy using the AirSeal® insufflation system. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Impact of AirSeal®insufflation system on respiratory and circulatory dynamics during laparoscopic abdominal surgery

Author

Kajiwara, Masatoshi, Nakashima, Ryo, Yoshimura, Fumihiro, and Hasegawa, Suguru

Abstract

The effect of the AirSeal®insufflation system on hemodynamic parameters, especially end-tidal carbon dioxide (EtCO2), during laparoscopic abdominal surgery remains unclear. This retrospective single-center study included 333 consecutive patients who underwent laparoscopic hepatectomy (n= 43), gastrectomy (n= 69), colectomy (n= 137), or proctectomy (n= 84) using the AirSeal®. Patient demographics and intraoperative hemodynamic parameters, such as EtCO2, peripheral capillary oxygen saturation (SpO2), and arterial systolic blood pressure (ABP), were collected and analyzed. EtCO2was evaluated during the entire operative period (whole period) as well as the pneumoperitoneum period until specimen removal (pneumoperitoneum period). We defined “positive respiratory and circulatory responses” (positive responses) as a decrease in EtCO2≥ 3 mmHg in addition to decreases in SpO2≥ 3% and ABP ≥ 10 mmHg simultaneously, which suggest possible carbon dioxide (CO2) embolism. The median EtCO2values of hepatectomy, gastrectomy, colectomy, and proctectomy in the whole period/pneumoperitoneum period were 37.3/37.4, 37.1/37.3, 37.4/37.9, and 38.2/38.4 mmHg, respectively. The EtCO2of proctectomy was significantly higher than that of gastrectomy during the whole and pneumoperitoneum periods (P< 0.05). In contrast, the EtCO2of hepatectomy was comparable to that of the other three surgeries in the whole and pneumoperitoneum periods. Meanwhile, nine (2.7%; eight hepatectomies and one proctectomy) patients showed positive responses, and one who underwent a partial hepatectomy developed a clinically manifested CO2embolism. Positive responses occurred during venous exposure or bleeding in all nine cases. Although the EtCO2of hepatectomy was comparable to that of the other surgeries using the AirSeal®, laparoscopic hepatectomy showed a tendency of CO2embolism. Thus, a secure and careful surgical approach is mandatory for laparoscopic hepatectomy using the AirSeal®insufflation system.

Published
2022
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34. Comparative Study of Transplantation of Hepatocytes at Various Differentiation Stages into Mice with Lethal Liver Damage

Author

Kamimura, Ryo, primary, Ishii, Takamichi, additional, Sasaki, Naoya, additional, Kajiwara, Masatoshi, additional, Machimoto, Takafumi, additional, Saito, Michiko, additional, Kohno, Kenji, additional, Suemori, Hirofumi, additional, Nakatsuji, Norio, additional, Ikai, Iwao, additional, Yasuchika, Kentaro, additional, and Uemoto, Shinji, additional

Published
2012
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35. Corrigendum to ‘Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics’ [Cancer Letters 308(2) (2011) 152–161]

Author

Sasaki, Naoya, primary, Ishii, Takamichi, additional, Kamimura, Ryo, additional, Kajiwara, Masatoshi, additional, Machimoto, Takafumi, additional, Nakatsuji, Norio, additional, Suemori, Hirofumi, additional, Ikai, Iwao, additional, Yasuchika, Kentaro, additional, and Uemoto, Shinji, additional

Published
2012
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42. Real‐world efficacy of radiomics versus clinical predictors for microvascular invasion in patients with hepatocellular carcinoma: Large cohort study.

Author

Kinoshita, Shotaro, Nakaura, Takeshi, Yoshizumi, Tomoharu, Itoh, Shinji, Ide, Takao, Noshiro, Hirokazu, Hamada, Takashi, Kuroki, Tamotsu, Takami, Yuko, Nagano, Hiroaki, Nanashima, Atsushi, Endo, Yuichi, Utsunomiya, Tohru, Kajiwara, Masatoshi, Miyoshi, Atsushi, Sakoda, Masahiko, Okamoto, Kohji, Beppu, Toru, Takatsuki, Mitsuhisa, and Noritomi, Tomoaki

Subjects
*HEPATITIS associated antigen, *RECEIVER operating characteristic curves, *RADIOMICS, *CANCER prognosis, *COMPUTED tomography
Abstract

Aim Methods Results Conclusions Microvascular invasion (MVI) affects the prognosis and treatment of hepatocellular carcinoma (HCC); however, its preoperative diagnosis is challenging. Analysis of computed tomography (CT) images using radiomics can detect MVI, but its effectiveness depends on the imaging conditions. We compared the efficacies of radiomics, clinical, and combined models for predicting MVI in HCC using nonstandardized scanning protocols.This multicenter study included 533 patients who underwent hepatic resection for HCC. Patients were divided randomly into training (n = 426) and test groups (n = 107). We manually extracted 3D CT features in hepatic arterial, portal venous, and venous phases. The radiomics model was trained by machine learning. A logistic regression model was developed based on clinical information, and a fused model was created integrating clinical information and radiomics prediction score (Rad_Score). We calculated areas under the receiver operating characteristic curves (AUCs) for the radiomics, clinical, and mixed models in the test groups.The clinical model incorporated hepatitis B virus surface antigen, tumor diameter, and log‐transformed α‐fetoprotein and des‐gamma‐carboxyprothrombin. The AUCs of the radiomics and clinical models were comparable (p = 0.76). Rad_Score was not an independent significant factor in the fused model (p = 0.40) and its addition did not improve the accuracy of the clinical model alone (p = 0.51).A clinical model is as effective as a CT radiomics model for predicting MVI status in patients with HCC based on real‐world scanning data, and integration of both models does not improve the predictive performance compared with a clinical model alone. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.

Author

Mae, Shin-Ichi, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhiko, Kajiwara, Masatoshi, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutoshi, Nakayama, Naoki, Cowan, Chad A., Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P., Yamanaka, Shinya, and Osafune, Kenji

Abstract

A method for stimulating the differentiation of human pluripotent stem cells into kidney lineages remains to be developed. Most cells in kidney are derived from an embryonic germ layer known as intermediate mesoderm. Here we show the establishment of an efficient system of homologous recombination in human pluripotent stem cells by means of bacterial artificial chromosome-based vectors and single-nucleotide polymorphism array-based detection. This system allowed us to generate human-induced pluripotent stem cell lines containing green fluorescence protein knocked into OSR1, a specific intermediate mesoderm marker. We have also established a robust induction protocol for intermediate mesoderm, which produces up to 90% OSR1+ cells. These human intermediate mesoderm cells can differentiate into multiple cell types of intermediate mesoderm-derived organs in vitro and in vivo, thereby supplying a useful system to elucidate the mechanisms of intermediate mesoderm development and potentially providing a cell source for regenerative therapies of the kidney. [ABSTRACT FROM AUTHOR]

Published
2013
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