34 results on '"Kaku, Tomohiro"'
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2. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement
3. TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window
4. Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists
5. Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists
6. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer
7. 17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors
8. 17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors
9. TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window
10. Synthetic studies on (1 S)-1-(6,7-dimethoxy-2-naphthyl)-1-(1 H-imidazol-4-yl)-2-methylpropan-1-ol as a selective C 17,20-lyase inhibitor
11. Stereocontrolled synthesis of (1 S)-1-(1 H-imidazol-4-yl)-1-(6-methoxy-2-naphthyl)-2-methylpropan-1-ol as a potent C 17,20-lyase inhibitor
12. C 17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1 H-imidazoles as novel C 17,20-lyase inhibitors
13. C 17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C 17,20-lyase inhibitors
14. Inhibition of high K+-evoked γ-aminobutyric acid release by sodium nitroprusside in rat hippocampus
15. Electrophysiological Comparison between Parkinson’s Disease and Alzheimer’s Disease
16. Sodium nitroprusside-induced seizures and adenosine release in rat hippocampus
17. 配列プロファイル生成の改良によるタンパク質天然変性領域予測の高速化
18. Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys
19. Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats
20. Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys
21. Abstract DD01-03: TAK-700, an inhibitor of 17,20-lyase
22. C17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors
23. Synthetic studies on (1S)-1-(6,7-dimethoxy-2-naphthyl)-1-(1H-imidazol-4-yl)-2-methylpropan-1-ol as a selective C17,20-lyase inhibitor
24. C17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors
25. Different effects of eNOS and nNOS inhibition on transient forebrain ischemia
26. 7-Nitroindazole reduces nitric oxide concentration in rat hippocampus after transient forebrain ischemia
27. Adenosine transport inhibitors enhance high K+-evoked taurine release from rat hippocampus
28. Endogenous adenosine exerts inhibitory effects upon the development of spreading depression and glutamate release induced by microdialysis with high K+ in rat hippocampus
29. Effects of endogeneous adenosine upon spreading depression and glutamate release induced by microdialysis with high K+ in rat hippocampus
30. Periventricular lucencies on computed tomography in multiple cerebral infarcts: Correlation with cerebral blood flow measurements
31. C17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors
32. Inhibition of high K+-evoked γ-aminobutyric acid release by sodium nitroprusside in rat hippocampus
33. Stereocontrolled synthesis of (1S)-1-(1H-imidazol-4-yl)-1-(6-methoxy-2-naphthyl)-2-methylpropan-1-ol as a potent C17,20-lyase inhibitor
34. Inhibition of high K+-evoked gamma-aminobutyric acid release by sodium nitroprusside in rat hippocampus.
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